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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MED23 Gene

protein-coding GIFtS: 56
GCID: GC06M131895

mediator complex subunit 23

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP3)

Explore 7 diseases affiliated with
MED23 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 23¹ ² ³		CRSP133²
CRSP3¹ ² ³		MRT18²
DRIP130¹ ² ³		SUR-2²
CRSP130¹ ²		Mediator Of RNA Polymerase II Transcription Subunit 23²
Activator-Recruited Cofactor 130 KDa Component² ³		Vitamin D3 Receptor Interacting Protein²
Cofactor Required For Sp1 Transcriptional Activation Subunit 3² ³		KIAA1216³
ARC130² ³		CRSP Complex Subunit 3³
SUR2² ³		HSur-2¹
Sur2¹		Protein Sur-2 Homolog³
Cofactor Required For Sp1 Transcriptional Activation, Subunit 3, 130kDa¹		Transcriptional Coactivator CRSP130³
130 KDa Transcriptional Co-Activator²		Vitamin D3 Receptor-Interacting Protein Complex 130 KDa Component³
133 KDa Transcriptional Co-Activator²

External Ids:	HGNC: 2372¹	Entrez Gene: 9439²	Ensembl: ENSG00000112282⁷	OMIM: 605042⁵	UniProtKB: Q9ULK4³

Export aliases for MED23 gene to outside databases

Previous GC identifers: GC06M131937 GC06M129476

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED23:

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional

enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA

polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1

activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a

component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with

TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also

acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have

been described for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4

Function: Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By

similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all

RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory

proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct

interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex

with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus

E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling

Gene Wiki entry for MED23 (CRSP3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MED23 gene promoter:
GR HFH-3 AML1a GR-beta Lmo2 FOXI1 SRY FOXO4 Sox9 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MED23 promoter sequence

Search SABiosciences Chromatin IP Primers for MED23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.33-q24.1 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q22.33-q24.1

MED23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED23 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M131895: view genomic region (about GC identifiers)

Start:	131,895,106 bp from pter	End:	131,949,369 bp from pter
Size:	54,264 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4 (See protein sequence)

Recommended Name: Mediator of RNA polymerase II transcription subunit 23

Size: 1368 amino acids; 156474 Da

Subunit: Interacts with ELK1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6,

MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22,

MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8

subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than

Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex

lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with

CEBPB, CTNNB1, and GLI3. Interacts with the adenovirus E1A protein

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAD12724.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=AAD31729.1; Type=Frameshift; Positions=945, 950; Sequence=BAA86530.1; Type=Erroneous initiation;

Note=Translation N-terminally shortened;

Secondary accessions: O95403 Q5JWT3 Q5JWT4 Q6P9H6 Q9H0J2 Q9NTT9 Q9NTU0 Q9Y5P7 Q9Y667

Alternative splicing: 5 isoforms: Q9ULK4-1 Q9ULK4-2 Q9ULK4-3 Q9ULK4-4 Q9ULK4-5

Explore the universe of human proteins at neXtProt for MED23: NX_Q9ULK4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULK4

MED23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001257450.1 NP_001257451.1 NP_004821.2 NP_057063.2

ENSEMBL proteins:

ENSP00000346588 ENSP00000357047 ENSP00000357039 ENSP00000357037 ENSP00000357032

ENSP00000384536 ENSP00000439977 ENSP00000437818 ENSP00000445072

Reactome Protein details: Q9ULK4
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for MED23
	GenScript Custom Purified and Recombinant Proteins Services for MED23
	Novus Biologicals MED23 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MED23

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IDA	9989412
GO:0016592	mediator complex	IEA	--

MED23 for ontologies About GeneDecksing

MED23 Antibody Products:

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	GenScript Custom Superior Antibodies Services for MED23
	Novus Biologicals MED23 Antibodies
	Search for Antibodies for MED23 at Abcam
	Uscn Antibodies for MED23
	Search ThermoFisher Antibodies for MED23

Assay Products for MED23:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MED23
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MED23

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MED23 for domains About GeneDecksing

1 InterPro domain/family:

IPR021629 Mediator_Med23

Graphical View of Domain Structure for InterPro Entry Q9ULK4

ProtoNet protein and cluster: Q9ULK4

UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4

Similarity: Belongs to the Mediator complex subunit 23 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4

Function: Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By

similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all

RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory

proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct

interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex

with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus

E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MED23 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED23
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MED23:
		hsa-miR-10b* hsa-miR-2115 hsa-miR-1303 hsa-miR-15b* hsa-miR-3924
		SwitchGear 3'UTR luciferase reporter plasmid: MED23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED23 OriGene shRNA RFP: MED23 OriGene siRNA: MED23
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED23

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MED23

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED23 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED23 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MED23 (NM_004830)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED23
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED23

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MED23
		Search LifeMap BioReagents cell lines for MED23

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED23

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	TAS	9989412
GO:0005515	protein binding	IPI	17438371

MED23 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MED23:

Increased cell death HMECs cel

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Med23^tm1Berk for MED23
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Med23):

cardiovascular system	cellular	embryogenesis	growth/size	mortality/aging
nervous system

MED23 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

HIV Infection

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

0.28

Transcription_Ligand-Dependent Transcription of Retinoid-Target genes

0.28

Transcriptional Regulation of White Adipocyte Differentiation

Transcriptional Regulation of White Adipocyte Differentiation

1.00

Axon guidance

Developmental Biology

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MED23

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 GeneGo (Thomson Reuters) Pathway for MED23

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

4 Reactome Pathways for MED23

	Developmental Biology
	Transcriptional Regulation of White Adipocyte Differentiation
	Generic Transcription Pathway
	Gene Expression

MED23 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MED23

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/122 Interacting proteins for MED23 (Q9ULK4^{2, 3} ENSP00000357047⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 122)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED1	Q15648²^,³, ENSP00000300651⁴	MINT-6744331 MINT-6744763 I2D: score=1 STRING: ENSP00000300651
MED14	O60244²^,³, ENSP00000323720⁴	MINT-6744331 MINT-6744763 I2D: score=1 STRING: ENSP00000323720
CDK8	P49336²^,³, ENSP00000370938⁴	MINT-6744763 I2D: score=1 STRING: ENSP00000370938
MED15	Q96RN5²^,³, ENSP00000263205⁴	MINT-6744763 I2D: score=1 STRING: ENSP00000263205
MED12	Q93074²^,³, ENSP00000363193⁴	MINT-6744331 MINT-8151872 MINT-8151888 MINT-8151852 I2D: score=2 STRING: ENSP00000363193

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IDA	9989412
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	9989412
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0010467	gene expression	TAS	--

MED23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MED23 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MED23
1 PharmGKB related drug/compound annotation for MED23 gene

Drug/compound	PharmGKB Annotation
selective beta-2-adrenoreceptor agonists	CA

About this table

Search CenterWatch for drugs/clinical trials and news about MED23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MED23 gene (4 alternative transcripts):

NM_001270521.1 NM_001270522.1 NM_004830.3 NM_015979.3

Unigene Cluster for MED23:

Mediator complex subunit 23

Hs.29679 [show with all ESTs]

Unigene Representative Sequence: NM_004830

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354577(uc003qcq.3) ENST00000368068(uc003qcs.1) ENST00000479213(uc003qcr.1)

ENST00000368060(uc011eca.1) ENST00000368058 ENST00000484885 ENST00000368053

ENST00000489888 ENST00000403834 ENST00000545957 ENST00000540546(uc003qct.1 uc011ecb.1)

ENST00000539158

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MED23 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED23
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MED23:
		hsa-miR-10b* hsa-miR-2115 hsa-miR-1303 hsa-miR-15b* hsa-miR-3924
		SwitchGear 3'UTR luciferase reporter plasmid: MED23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED23 OriGene shRNA RFP: MED23 OriGene siRNA: MED23
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED23

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED23 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED23 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MED23 (NM_004830)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED23
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED23

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED23 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MED23
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED23
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED23

Additional cDNA sequence:

AB033042.1 AF104255.1 AF105332.1 AF135022.1 AJ420587.1 AK304711.1 AK315030.1 AL136776.1

BC007088.1 BC060759.1 EU392520.1 EU392521.1 EU392522.1 EU392523.1 EU392524.1 EU392525.1

EU392526.1 EU392527.1 EU392528.1 EU392529.1 EU392530.1 EU392531.1 EU392532.1

15 DOTS entries:

DT.412112 DT.65285082 DT.100781607 DT.433336 DT.100685938 DT.100781610 DT.97831889 DT.92429389

DT.100781611 DT.121372469 DT.95350276 DT.97794082 DT.91716358 DT.95364047 DT.97777601

24/118 AceView cDNA sequences (see all 118):

BI335881 BF034381 AA504481 BC060759 CA489049 NM_015979 AI201868 BG776600

AA325467 AA418704 AL136776 AA418712 AW243916 BC007088 AL697760 AL699590

BU676853 BQ720920 CB267206 AA876357 R77756 CB162806 BU689464 AI554092

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MED23 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25a	·
SP1:																																																			-
SP2:																																																			-
SP3:

ExUns:	25b	^	26a	·	26b	^	27	^	28a	·	28b
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for MED23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MED23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTAAATGGT

About this image

MED23 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MED23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MED23

SOURCE GeneReport for Unigene cluster: Hs.29679

SABiosciences Custom PCR Arrays for MED23

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED23 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MED23
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED23
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED23

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED23

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED23 gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Med23^{1 , 5}	mediator complex subunit 23^{1, 5}	87.95(n)¹ 96.34(a)¹		10 (12.26 cM)⁵ 70208¹ NM_001166416.1¹ NP_001159888.1¹ 24869986⁵
chicken (Gallus gallus)	Aves	MED23¹	mediator complex subunit 23	82.72(n) 95.47(a)		426927 XM_424537.3 XP_424537.3
lizard (Anolis carolinensis)	Reptilia	MED23⁶	--	94(a)	1 ↔ 1	1(204139174-204187435)
African clawed frog (Xenopus laevis)	Amphibia	MGC68685²	hypothetical protein MGC68685	78.33(n)		BC063725.1
zebrafish (Danio rerio)	Actinopterygii	med23¹	mediator complex subunit 23	75.52(n) 91.22(a)		445483 NM_001003990.1 NP_001003990.1
fruit fly (Drosophila melanogaster)	Insecta	MED23¹	Mediator complex subunit 23	55.63(n) 50.27(a)		37639 NM_137891.2 NP_611735.1
worm (Caenorhabditis elegans)	Secernentea	sur-2¹	Protein SUR-2	39.97(n) 23.6(a)		173345 NM_061174.4 NP_493575.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G23230⁶	uncharacterized protein	14(a)	1 ↔ 1	1(8244440-8251795)
rice (Oryza sativa)	Liliopsida	--	expressed protein	14(a)	1 ↔ 1	2(30536300-30547711)

ENSEMBL Gene Tree for MED23 (if available)
TreeFam Gene Tree for MED23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111824376^1,2	C,	--	129487255(+)	`GGAGAC/TGGAAG`	2	--	int¹		1		NA	2
rs79926878^1,2	F,	--	129487567(+)	`TAAACG/TGTAAT`	2	--	int¹		1		WA	118
rs75256830^1,2	F,	--	129489033(+)	`GCACAC/AAGCCG`	4	--	ds500¹ int¹		1		WA	118
rs41285340^1,2	C,F,	--	129489073(+)	`TCACAC/TGGTTT`	4	--	ut3¹ int¹		2		WA NA	238
rs10457573^1,2	C,F,H,	--	129489334(+)	`AAGTTC/TAAGAA`	4	--	ut3¹ int¹		12		NS EA NA EU	2253
rs77707529^1,2	C,	--	129490075(+)	`GGCTTG/TTGGAG`	8	K Q	mis¹		0	--	--	--	--
rs77312336^1,2	F,	--	129490400(+)	`TATGTG/ACATGT`	4	--	int¹		1		WA	118
rs75988928^1,2	F,	--	129490401(+)	`ATGTGC/AATGTC`	4	--	int¹		1		WA	118
rs79013811^1,2		--	129490595(+)	`AAAGTC/TCTTTG`	4	--	int¹		0	--	--	--	--
rs79325891^1,2	F,	--	129490683(+)	`AGATCT/AACTCT`	4	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for MED23 (131895106 - 131949369 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MED23: --
Human Gene Mutation Database (HGMD): MED23

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED23

DNA2.0 Custom Variant and Variant Library Synthesis for MED23

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MED23 for disorders About GeneDecksing

OMIM gene information: 605042 OMIM disorders: --

UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4

Defects in MED23 are the cause of mental retardation autosomal recessive type 18 (MRT18) [MIM:614249]. Mental

retardation is characterized by significantly below average general intellectual functioning associated with

impairments in adaptative behavior and manifested during the developmental period

7 diseases for MED23: About MalaCards

thyroiditis conjunctivitis intellectual disability melanoma metastasis

melanoma cholesterol neuronitis

Human Genome Epidemiology (HuGE) Navigator: MED23 (4 documents)

Export disorders for MED23 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MED23 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with MED23)

Utopia: connect your pdf to the dynamic
world of online information

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)^{1, 2, 3} Ryu S.... Tjian R. (1999)
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. (PubMed id 21868677)^{1, 2} Hashimoto S....Colleaux L. (2011)
MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)^{1, 2} Zhang X....Roeder R.G. (2005)
Ras induces mediator complex exchange on C/EBP beta. (PubMed id 14759369)^{1, 2} Mo X.... Leutz A. (2004)
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)^{1, 2} Sato S....Conaway R.C. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PubMed id 11867769)^{1, 2} Kang Y.K.... Roeder R.G. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. (PubMed id 10353252)^{1, 2} Boyer T.G.... Berk A.J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9439	HGNC: 2372	AceView: CRSP3	Ensembl:ENSG00000112282	euGenes: HUgn9439
ECgene: MED23	H-InvDB: MED23

(According to HUGE)
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HUGE: KIAA1216

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MED23	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MED23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MED23 gene:
Search GeneIP for patents involving MED23

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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MED23 Gene

mediator complex subunit 23

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MED23 (Gene Symbol)
Mediator Complex Subunit 23
CRSP3
DRIP130
CRSP130
Activator-Recruited Cofactor 130 KDa Component
Cofactor Required For Sp1 Transcriptional Activation Subunit 3
ARC130
SUR2
Sur2
Cofactor Required For Sp1 Transcriptional Activation, Subunit 3, 130kDa
130 KDa Transcriptional Co-Activator
133 KDa Transcriptional Co-Activator
CRSP133
MRT18
SUR-2
Mediator Of RNA Polymerase II Transcription Subunit 23
Vitamin D3 Receptor Interacting Protein
KIAA1216
CRSP Complex Subunit 3
HSur-2
Protein Sur-2 Homolog
Transcriptional Coactivator CRSP130
Vitamin D3 Receptor-Interacting Protein Complex 130 KDa Component

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MED23 Gene

mediator complex subunit 23

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