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MED23 Gene

protein-coding   GIFtS: 58
GCID: GC06M131895

Mediator Complex Subunit 23

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP3)
  See MED23-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 231 2 3     CRSP1302
CRSP31 2 3     CRSP1332
Activator-Recruited Cofactor 130 KDa Component2 3     SUR-22
Cofactor Required For Sp1 Transcriptional Activation Subunit 32 3     Mediator Of RNA Polymerase II Transcription Subunit 232
ARC1302 3     Vitamin D3 Receptor Interacting Protein2
DRIP1302 3     KIAA12163
SUR22 3     CRSP Complex Subunit 33
MRT182 5     hSur-23
Cofactor Required For Sp1 Transcriptional Activation, Subunit 3, 130kDa1     Protein Sur-2 Homolog3
130 KDa Transcriptional Co-Activator2     Transcriptional Coactivator CRSP1303
133 KDa Transcriptional Co-Activator2     Vitamin D3 Receptor-Interacting Protein Complex 130 KDa Component3

External Ids:    HGNC: 23721   Entrez Gene: 94392   Ensembl: ENSG000001122827   OMIM: 6050425   UniProtKB: Q9ULK43   

Export aliases for MED23 gene to outside databases

Previous GC identifers: GC06M131937 GC06M129476


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED23 Gene:
The activation of gene transcription is a multistep process that is triggered by factors that recognize
transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation
by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required
for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein
is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which
interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and
cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for MED23 Gene:
MED23 (mediator complex subunit 23) is a protein-coding gene. Diseases associated with MED23 include mental retardation, autosomal recessive 18, and mental retardation, autosomal recessive 43. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4
Function: Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By
similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly
all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional
activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to
activated Ras signaling

Gene Wiki entry for MED23 (CRSP3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED23 gene promoter:
         GR   HFH-3   AML1a   GR-beta   Lmo2   FOXI1   SRY   FOXO4   Sox9   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED23 promoter sequence
   Search Chromatin IP Primers for MED23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.33-q24.1   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q22.33-q24.1

MED23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED23 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M131895:  view genomic region     (about GC identifiers)

Start:
131,895,106 bp from pter      End:
131,949,369 bp from pter
Size:
54,264 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 23  
Size: 1368 amino acids; 156474 Da
Subunit: Interacts with ELK1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4,
MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20,
MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12,
MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module
is less active than Mediator lacking this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP,
DRIP, PC2, SMCC and TRAP. Interacts with CEBPB, CTNNB1, and GLI3. Interacts with the adenovirus E1A protein
Sequence caution: Sequence=AAD12724.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAD31729.1; Type=Frameshift; Positions=945, 950; Sequence=BAA86530.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: B9TX55 O95403 Q5JWT3 Q5JWT4 Q6P9H6 Q9H0J2 Q9NTT9 Q9NTU0 Q9Y5P7 Q9Y667
Alternative splicing: 6 isoforms:  Q9ULK4-1   Q9ULK4-2   Q9ULK4-3   Q9ULK4-4   Q9ULK4-5   Q9ULK4-6   

Explore the universe of human proteins at neXtProt for MED23: NX_Q9ULK4

Explore proteomics data for MED23 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys242, Lys253, Lys260, Lys673, Lys1082
  • Modification sites at PhosphoSitePlus

  • See MED23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257450.1  NP_001257451.1  NP_004821.2  NP_057063.2  

    ENSEMBL proteins: 
     ENSP00000346588   ENSP00000357047   ENSP00000357039   ENSP00000357037   ENSP00000357032  
     ENSP00000384536   ENSP00000439977   ENSP00000437818   ENSP00000445072  
    Reactome Protein details: Q9ULK4

    MED23 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MED23
    GenScript Custom Purified and Recombinant Proteins Services for MED23
    Novus Biologicals MED23 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MED23 

     
    antibodies-online proteins for MED23 (2 products) 

     
    antibodies-online peptides for MED23

    MED23 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MED23
    OriGene Custom Antibody Services for MED23
    Novus Biologicals MED23 Antibodies
    Search for Antibodies for MED23 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for MED23
    antibodies-online antibodies for MED23 (36 products) 

    MED23 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED23
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED23
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MED23 
    antibodies-online kits for MED23 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021629 Mediator_Med23

    Graphical View of Domain Structure for InterPro Entry Q9ULK4

    ProtoNet protein and cluster: Q9ULK4

    UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4
    Similarity: Belongs to the Mediator complex subunit 23 family


    Find genes that share domains with MED23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED23_HUMAN, Q9ULK4
    Function: Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By
    similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly
    all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional
    activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to
    activated Ras signaling

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS9989412
    GO:0005515protein binding IPI17438371
         
    Find genes that share ontologies with MED23           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MED23:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Med23):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     nervous system 

    Find genes that share phenotypes with MED23           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Med23tm1Berk for MED23

       genOway: Develop your customized and physiologically relevant rodent model for MED23

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED23:
    hsa-mir-320a (MIRT044390), hsa-mir-26b-5p (MIRT029125)

    Block miRNA regulation of human, mouse, rat MED23 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MED23:
    hsa-miR-10b* hsa-miR-2115 hsa-miR-1303 hsa-miR-15b* hsa-miR-3924
    SwitchGear 3'UTR luciferase reporter plasmidMED23 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED23
    Predesigned siRNA for gene silencing in human, mouse, rat MED23

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED23

    Clone
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    OriGene clones in human, mouse for MED23 (see all 12)
    OriGene ORF clones in mouse, rat for MED23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED23 (NM_004830)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED23

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED23
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED23 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED23_HUMAN, Q9ULK4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA9989412
    GO:0016592mediator complex IEA--

    Find genes that share ontologies with MED23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED23 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes


    Find genes that share SuperPaths with MED23           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MED23
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    3 Reactome Pathways for MED23
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED23
    Interactions:

        Search GeneGlobe Interaction Network for MED23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED23 (Q9ULK42, 3 ENSP000003570474) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156482, 3, ENSP000003006514MINT-6744331 MINT-6744763 I2D: score=1 STRING: ENSP00000300651
    MED14O602442, 3, ENSP000003237204MINT-6744331 MINT-6744763 I2D: score=1 STRING: ENSP00000323720
    CDK8P493362, 3, ENSP000003709384MINT-6744763 I2D: score=1 STRING: ENSP00000370938
    MED15Q96RN52, 3, ENSP000002632054MINT-6744763 I2D: score=1 STRING: ENSP00000263205
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IDA9989412
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9989412
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with MED23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED23

    1 PharmGKB related drug/compound annotation for MED23 gene    About this table
    Drug/compound PharmGKB Annotation
    selective beta-2-adrenoreceptor agonistsCA  



    Find genes that share compounds with MED23           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MED23 gene (4 alternative transcripts): 
    NM_001270521.1  NM_001270522.1  NM_004830.3  NM_015979.3  

    Unigene Cluster for MED23:

    Mediator complex subunit 23
    Hs.29679  [show with all ESTs]
    Unigene Representative Sequence: NM_004830
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354577(uc003qcq.3) ENST00000368068(uc003qcs.1) ENST00000479213(uc003qcr.1)
    ENST00000368060(uc011eca.1) ENST00000368058 ENST00000484885 ENST00000368053
    ENST00000489888 ENST00000403834 ENST00000545957 ENST00000540546(uc003qct.1 uc011ecb.1)
    ENST00000539158
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate MED23:
    hsa-miR-10b* hsa-miR-2115 hsa-miR-1303 hsa-miR-15b* hsa-miR-3924
    SwitchGear 3'UTR luciferase reporter plasmidMED23 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MED23
    Clone
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    OriGene clones in human, mouse for MED23 (see all 12)
    OriGene ORF clones in mouse, rat for MED23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED23 (NM_004830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED23
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED23
    OriGene qSTAR qPCR primer pairs in human, mouse for MED23
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED23
      QuantiTect SYBR Green Assays in human, mouse, rat MED23
      QuantiFast Probe-based Assays in human, mouse, rat MED23

    Additional mRNA sequence: 

    AB033042.1 AF104255.1 AF105332.1 AF135022.1 AJ420587.1 AK304711.1 AK315030.1 AL136776.1 
    BC007088.1 BC060759.1 EU392520.1 EU392521.1 EU392522.1 EU392523.1 EU392524.1 EU392525.1 
    EU392526.1 EU392527.1 EU392528.1 EU392529.1 EU392530.1 EU392531.1 EU392532.1 

    15 DOTS entries:

    DT.412112  DT.65285082  DT.100781607  DT.433336  DT.100685938  DT.100781610  DT.97831889  DT.92429389 
    DT.100781611  DT.121372469  DT.95350276  DT.97794082  DT.91716358  DT.95364047  DT.97777601 

    Selected AceView cDNA sequences (see all 118):

    AF104255 BU625034 AA876357 BQ716472 NM_004830 BI335881 AA418704 CA489049 
    CB162806 AI201868 BG776600 AL697760 AL136776 R77756 BC060759 AA504481 
    NM_015979 BQ720920 AL699590 CD677400 AA418712 BU521161 BC007088 AW243916 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED23    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            

    ExUns: 25b ^ 26a · 26b ^ 27 ^ 28a · 28b
    SP1:                                    
    SP2:                                    
    SP3:                                    


    ECgene alternative splicing isoforms for MED23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAAATGGT
    MED23 Expression
    About this image

    MED23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29679
        Custom PCR Arrays for MED23
    Primer
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    OriGene qPCR primer pairs and template standards for MED23
    OriGene qSTAR qPCR primer pairs in human, mouse for MED23
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED23
    QuantiTect SYBR Green Assays in human, mouse, rat MED23
    QuantiFast Probe-based Assays in human, mouse, rat MED23
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED23 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med231 , 5 mediator complex subunit 231, 5 87.95(n)1
    96.34(a)1
      10 (12.26 cM)5
    702081  NM_001166416.11  NP_001159888.11 
     248699865 
    chicken
    (Gallus gallus)
    Aves MED231 mediator complex subunit 23 82.72(n)
    95.47(a)
      426927  XM_424537.4  XP_424537.3 
    lizard
    (Anolis carolinensis)
    Reptilia MED236
    mediator complex subunit 23
    92(a)
    1 ↔ 1
    1(204138116-204187628)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686852 hypothetical protein MGC68685 78.33(n)    BC063725.1 
    zebrafish
    (Danio rerio)
    Actinopterygii med231 mediator complex subunit 23 75.52(n)
    91.22(a)
      445483  NM_001003990.1  NP_001003990.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED231 Mediator complex subunit 23 55.73(n)
    50.38(a)
      37639  NM_001144269.1  NP_001137741.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sur-21 sur-2 40.23(n)
    24.17(a)
      173345  NM_061174.5  NP_493575.2 


    ENSEMBL Gene Tree for MED23 (if available)
    TreeFam Gene Tree for MED23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MED23 (see all 1086)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0665964
    Mental retardation, autosomal recessive 18 (MRT18)4--see VAR_0665962 P Q mis40--------
    rs1119790121,2
    C--129487000(+) AGTAGC/-CTTTT 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1119977191,2
    C--129503382(+) GCTGC-/TTTTTT 4 -- int11Minor allele frequency- T:0.00CSA 2
    rs1832490411,2
    --131895848(+) AAAGTC/TCTCTC 2 -- ds50010--------
    rs1391650921,2
    --131895851(+) GTCCTC/TTCACC 2 -- ds50010--------
    rs1886624641,2
    --131895871(+) CATTGC/TATAAT 2 -- ds50010--------
    rs1499353171,2
    --131895896(+) CACTTA/GCTTTT 2 -- ds50010--------
    rs1929889871,2
    --131895908(+) TGGCTC/TGTGAT 2 -- ds50010--------
    rs94930291,2
    C,F,H--131895909(+) GGCTCG/ATGATC 2 -- ds50015Minor allele frequency- A:0.02NS EA WA 538
    rs1440934221,2
    C--131896098(+) AATACA/GTTTGT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for MED23 (131895106 - 131949369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED23:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7968CNV Loss18304495
    nsv886668CNV Gain21882294

    Human Gene Mutation Database (HGMD): MED23
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED23
    DNA2.0 Custom Variant and Variant Library Synthesis for MED23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605042   
    OMIM disorders: 614249  
    UniProtKB/Swiss-Prot: MED23_HUMAN, Q9ULK4
  • Mental retardation, autosomal recessive 18 (MRT18) [MIM:614249]: A disorder characterized by
    significantly below average general intellectual functioning associated with impairments in adaptive behavior and
    manifested during the developmental period. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 2 diseases for MED23:    
    About MalaCards
    mental retardation, autosomal recessive 18    mental retardation, autosomal recessive 43


    Find genes that share disorders with MED23           About GenesLikeMe

    Genetic Association Database (GAD): MED23
    Human Genome Epidemiology (HuGE) Navigator: MED23 (4 documents)

    Export disorders for MED23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED23 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with MED23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (Nature 1999)
    2. MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. (PubMed id 21868677)1, 2 Hashimoto S....Colleaux L. (Science 2011)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    5. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    6. Ras induces mediator complex exchange on C/EBP beta. (PubMed id 14759369)1, 2 Mo X.... Leutz A. (Mol. Cell 2004)
    7. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PubMed id 11867769)1, 2 Kang Y.K.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9439 HGNC: 2372 AceView: CRSP3 Ensembl:ENSG00000112282 euGenes: HUgn9439
    ECgene: MED23 H-InvDB: MED23

    (According to HUGE)
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    HUGE: KIAA1216

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MED23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MED23 gene:
    Search GeneIP for patents involving MED23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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