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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED22 Gene

protein-coding   GIFtS: 55
GCID: GC09M136205

Mediator Complex Subunit 22

(Previous name: surfeit 5)
(Previous symbol: SURF5)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 221 2 3     MED242
SURF51 2 3 5     Mediator Of RNA Polymerase II Transcription Subunit 222
Surfeit Locus Protein 52 3     surf-52
Surfeit 51     Surf-53

External Ids:    HGNC: 114771   Entrez Gene: 68372   Ensembl: ENSG000001482977   OMIM: 1856415   UniProtKB: Q155283   

Export aliases for MED22 gene to outside databases

Previous GC identifers: GC09M135197 GC09M105707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED22 Gene:
This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription
by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription
factors. Alternatively spliced transcript variants encoding different isoforms have been observed. (provided by
RefSeq, Jul 2013)

GeneCards Summary for MED22 Gene: 
MED22 (mediator complex subunit 22) is a protein-coding gene. Diseases associated with MED22 include atypical autism, and among its related super-pathways are Axon guidance. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and protein binding.

UniProtKB/Swiss-Prot: MED22_HUMAN, Q15528
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED22 gene promoter:
         ER-alpha   HTF   Pax-2   Pax-2a   FOXL1   FOXI1   Pax-2b   HOXA5   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED22 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.2   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.1

MED22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED22 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136205:  view genomic region     (about GC identifiers)

Start:
136,205,160 bp from pter      End:
136,214,986 bp from pter
Size:
9,827 bases      Orientation:
minus strand

1 alternative location:
Chr9-,NW_003315925 166,999-174,211     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED22_HUMAN, Q15528 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 22  
Size: 200 amino acids; 22221 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Secondary accessions: B3KW83 B3KWX4 O76072 Q5T8U0
Alternative splicing: 2 isoforms:  Q15528-1   Q15528-2   

Explore the universe of human proteins at neXtProt for MED22: NX_Q15528

Explore proteomics data for MED22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15528

  • MED22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED22 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_598395.1  NP_852468.1  

    ENSEMBL proteins: 
     ENSP00000420393   ENSP00000420276   ENSP00000342343   ENSP00000341761   ENSP00000419098  
     ENSP00000361067   ENSP00000394781   ENSP00000420815   ENSP00000404178  
    Reactome Protein details: Q15528
    Human Recombinant Protein Products for MED22: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED22
    OriGene Protein Over-expression Lysate for MED22
    OriGene MassSpec for MED22 
    OriGene Custom Protein Services for MED22
    GenScript Custom Purified and Recombinant Proteins Services for MED22
    Novus Biologicals MED22 Proteins
    Novus Biologicals MED22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED22 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8586415
    GO:0016592mediator complex IDA14638676

    MED22 for ontologies           About GeneDecksing



    MED22 Antibody Products: 
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    Novus Biologicals MED22 Antibodies
    Abcam antibodies for MED22
    Cloud-Clone Corp. Antibodies for MED22 
    Search ThermoFisher Antibodies for MED22
    LSBio Antibodies in human, mouse, rat for MED22 

    Assay Products for MED22: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED22
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED22
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED22 
    Cloud-Clone Corp. CLIAs for MED22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009332 Mediator_Med22

    Graphical View of Domain Structure for InterPro Entry Q15528

    ProtoNet protein and cluster: Q15528

    1 Blocks protein domain: IPB009332 Surfeit locus 5

    UniProtKB/Swiss-Prot: MED22_HUMAN, Q15528
    Similarity: Belongs to the Mediator complex subunit 22 family


    MED22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED22_HUMAN, Q15528
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding IPI12584197
         
    MED22 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Med22):
     mortality/aging 

    MED22 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED22 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED22 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED22 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED22
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MED22:
    hsa-miR-1276 hsa-miR-3658 hsa-miR-29a* hsa-miR-3653 hsa-miR-766 hsa-miR-3616-3p hsa-miR-4267
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED22
    Sirion Biotech Customized adenovirus for overexpression of MED22

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED22 (see all 12)
    OriGene ORF clones in mouse, rat for MED22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED22 (NM_181491)
    Sino Biological Human cDNA Clone for MED22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED22
    Sirion Biotech Customized lentivirus for stable overexpression of MED22 
                         Customized lentivirus expression plasmids for stable overexpression of MED22 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED22
    Search LifeMap BioReagents cell lines for MED22
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED22 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for MED22
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation



    MED22 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for MED22 (Q155281, 2, 3 ENSP000003423434) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED11Q9P0861, 3, ENSP000002937774EBI-394687,EBI-394704 I2D: score=4 STRING: ENSP00000293777
    GOLM1Q8NBJ42, 3, ENSP000003733634MINT-64967 I2D: score=5 STRING: ENSP00000373363
    MED27Q6P2C83, ENSP000002920354I2D: score=4 STRING: ENSP00000292035
    MED30Q96HR33, ENSP000002973474I2D: score=3 STRING: ENSP00000297347
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    MED22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED22

    Search CenterWatch for drugs/clinical trials and news about MED22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED22 gene (3 alternative transcripts): 
    NM_133640.4  NM_181491.2  NM_006752.4  

    Unigene Cluster for MED22:

    Mediator complex subunit 22
    Hs.78354  [show with all ESTs]
    Unigene Representative Sequence: AK124518
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491289 ENST00000486395 ENST00000343730(uc004cdc.3) ENST00000344469(uc004cdd.3)
    ENST00000476080 ENST00000471524 ENST00000371999 ENST00000446777 ENST00000494177
    ENST00000457204 ENST00000482295
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED22
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MED22:
    hsa-miR-1276 hsa-miR-3658 hsa-miR-29a* hsa-miR-3653 hsa-miR-766 hsa-miR-3616-3p hsa-miR-4267
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED22
    Clone
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    OriGene clones in human, mouse for MED22 (see all 12)
    OriGene ORF clones in mouse, rat for MED22
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    GenScript: all cDNA clones in your preferred vector (see all 2): MED22 (NM_181491)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED22
    Sirion Biotech Customized lentivirus for stable overexpression of MED22 
                         Customized lentivirus expression plasmids for stable overexpression of MED22 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MED22
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED22

    Additional mRNA sequence: 

    AJ224359.1 AJ224360.1 AK124518.1 AK126069.1 BC024225.2 BC040111.1 X85178.1 

    12 DOTS entries:

    DT.317349  DT.102830143  DT.100738291  DT.121151757  DT.102830142  DT.100814607  DT.444755  DT.121151780 
    DT.91889520  DT.100028628  DT.121152215  DT.95110123 

    24/432 AceView cDNA sequences (see all 432):

    NM_181491 BX396541 CB122347 NM_006753 BM561337 AJ224360 BU860410 BU845334 
    BM681034 AI653533 BQ422401 BC006197 CR617785 BM911990 AA507056 NM_133640 
    BQ011027 BX444187 CR599878 BM817494 CR617587 BM915490 CR617292 BE906252 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED22    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:              -                                 
    SP2:                                                
    SP3:              -     -                           


    ECgene alternative splicing isoforms for MED22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED22 expression in normal human tissues (normalized intensities)      MED22 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MED22 Expression
    About this image


    MED22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Dermis (Integumentary System)
             Guard Dermal Papilla Cells Dermal Papilla
     
     Prostate (Endocrine System)

    See MED22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED22

    SOURCE GeneReport for Unigene cluster: Hs.78354
        SABiosciences Custom PCR Arrays for MED22
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED22 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med221 , 5 mediator complex subunit 221, 5 89.95(n)1
    95.48(a)1
      2 (19.09 cM)5
    209331  NM_001033908.11  NP_001029080.11 
     269052625 
    chicken
    (Gallus gallus)
    Aves MED221 mediator complex subunit 22 80.05(n)
    94.89(a)
      417159  NM_001045830.1  NP_001039295.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED226
    Uncharacterized protein
    68(a)
    1 ↔ 1
    AAWZ02038880(2074-10137)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.293962 Xenopus laevis transcribed sequence with moderate similarity more 76.69(n)    48029694 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.158922 Danio rerio, clone IMAGE5914359, mRNA 78.15(n)    BC049480.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED221 Mediator complex subunit 22 68.19(n)
    66.41(a)
      31038  NM_130514.4  NP_569870.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-226
    Mediator of RNA polymerase II transcription subuni...
    31(a)
    1 ↔ 1
    II(10301163-10301888)


    ENSEMBL Gene Tree for MED22 (if available)
    TreeFam Gene Tree for MED22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED22 gene
    1 SIMAP similar gene for MED22 using alignment to 7 protein entries:     MED22_HUMAN (see all proteins):
    Surf5

    MED22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/162 SNPs in MED22 are shown (see all 162)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6082921,2
    C,F--136207302(+) CCCCAT/CACTTC 2 -- ds50017Minor allele frequency- C:0.45EA NA CSA 149
    rs1896015011,2
    --136207394(+) GACACA/TGGGTC 2 -- ds50010--------
    rs793129601,2
    F--136207529(+) CGGCTC/TTGGTA 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1178861901,2
    C,F--136207689(+) CTGCTC/TGGACA 2 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1479256911,2
    --136207721(+) GTCCTA/GGACTG 2 -- ds50010--------
    rs1499770181,2
    C--136207768(+) GTGGC-/GGGGG 
            
    GGTGT
    2 -- ut310--------
    rs2008597211,2
    C--136207771(-) AAAACA/CCCGCC 2 -- ut310--------
    rs1930890741,2
    --136207838(+) GCGTGG/TGCAGC 2 -- ut310--------
    rs116551,2
    C,F,H--136207843(-) CAGCTG/ACTGCC 2 -- ut31 ese319Minor allele frequency- A:0.06MN NS EA NA 2638
    rs6219071,2
    C,F,A,H--136208044(+) CCTGCC/TCCACT 2 -- ut31 ese314Minor allele frequency- T:0.03NA EA NS 1934

    HapMap Linkage Disequilibrium report for MED22 (136205160 - 136214986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MED22:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv894076CNV Loss21882294
    dgv8325n71CNV Loss21882294
    nsv894079CNV Loss21882294
    nsv894080CNV Loss21882294
    nsv894057CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 185641    OMIM disorders: --

    2 diseases for MED22:    About MalaCards
    atypical autism    

    1 disease from the University of Copenhagen DISEASES database for MED22:
    Atypical autism

    MED22 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED22
    Human Genome Epidemiology (HuGE) Navigator: MED22 (3 documents)

    Export disorders for MED22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED22 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with MED22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene. (PubMed id 8586415)1, 2, 9 Garson K.... Fried M. (1995)
    2. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. (PubMed id 11891058)1, 2, 9 Angiolillo A....Pietropaolo C. (2002)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 3 Sato S....Conaway R.C. (2004)
    7. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (2003)
    8. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. (PubMed id 8499913)1, 3 Yon J....Fried M. (1993)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    10. Identification of the hypoxia-inducible factor 2a nucl ear interactome in melanoma cells reveals master proteins involved in melanoma d evelopment. (PubMed id 23275444)1 Steunou A.L....Nieto L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6837 HGNC: 11477 AceView: SURF5andSURF6 Ensembl:ENSG00000148297 euGenes: HUgn6837
    ECgene: MED22 H-InvDB: MED22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED22 gene:
    Search GeneIP for patents involving MED22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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