Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MED22 Gene

Aliases for MED22 Gene

  • Mediator Complex Subunit 22 2 3 4 5
  • Surfeit Locus Protein 5 3 4
  • Surf-5 3 4
  • SURF5 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 22 3
  • Surfeit 5 2
  • MED24 3

External Ids for MED22 Gene

Previous HGNC Symbols for MED22 Gene

  • SURF5

Previous GeneCards Identifiers for MED22 Gene

  • GC09M135197
  • GC09M136205
  • GC09M105707

Summaries for MED22 Gene

Entrez Gene Summary for MED22 Gene

  • This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

GeneCards Summary for MED22 Gene

MED22 (Mediator Complex Subunit 22) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED22 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED22 Gene

Genomics for MED22 Gene

Regulatory Elements for MED22 Gene

Enhancers for MED22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G133367 1.5 Ensembl ENCODE dbSUPER 12.9 -22.2 -22219 6.0 YY1 TCF12 ZNF121 ZNF766 GATA2 REST ZNF488 MBD2 SMARCA4 GLIS1 SURF6 SURF1 ADAMTS13 MED22 RPL7A SNORD24 SNORD36B ENSG00000201451 ENSG00000230064 GBGT1
GH09G133416 1.5 FANTOM5 ENCODE 11.7 -69.8 -69822 3.5 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SURF1 SURF6 LINC00094 ADAMTS13 CACFD1 SURF2 MED22 RPL7A SNORD36A SNORD36C
GH09G133420 1.2 Ensembl ENCODE 11.7 -73.1 -73079 2.3 HDGF TBP PKNOX1 FOXA2 WRNIP1 ARID4B RAD21 ZBTB40 RFX5 ZEB1 SURF1 CACFD1 SURF2 MED22 SNORD24 SNORD36A SNORD36B SNORD36C RPL7A ADAMTS13
GH09G133459 1.1 ENCODE 10.3 -112.3 -112277 2.8 HDGF FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CACFD1 SURF1 SURF2 SNORD36A SNORD36C SNORD36B SNORD24 RPL7A MED22 ADAMTS13
GH09G133267 1 ENCODE 11.2 +78.8 78754 2.8 HDGF PKNOX1 ATF1 CREB3L1 TCF12 ZNF766 GLIS2 ZNF263 REST ZNF592 ABO ENSG00000201451 ENSG00000230064 SURF6 MED22 RPL7A SNORD24 SNORD36A SNORD36B SNORD36C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED22 on UCSC Golden Path with GeneCards custom track

Promoters for MED22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242571 56 2201 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for MED22 Gene

Chromosome:
9
Start:
133,338,323 bp from pter
End:
133,348,156 bp from pter
Size:
9,834 bases
Orientation:
Minus strand

Genomic View for MED22 Gene

Genes around MED22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED22 Gene

Proteins for MED22 Gene

  • Protein details for MED22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15528-MED22_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 22
    Protein Accession:
    Q15528
    Secondary Accessions:
    • B3KW83
    • B3KWX4
    • O76072
    • Q5T8U0

    Protein attributes for MED22 Gene

    Size:
    200 amino acids
    Molecular mass:
    22221 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

    Alternative splice isoforms for MED22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED22 Gene

Post-translational modifications for MED22 Gene

  • Ubiquitination at posLast=1111
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MED22 Gene

Domains & Families for MED22 Gene

Gene Families for MED22 Gene

Protein Domains for MED22 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MED22 Gene

Graphical View of Domain Structure for InterPro Entry

Q15528

UniProtKB/Swiss-Prot:

MED22_HUMAN :
  • Belongs to the Mediator complex subunit 22 family.
Family:
  • Belongs to the Mediator complex subunit 22 family.
genes like me logo Genes that share domains with MED22: view

Function for MED22 Gene

Molecular function for MED22 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 12584197
genes like me logo Genes that share ontologies with MED22: view
genes like me logo Genes that share phenotypes with MED22: view

Animal Models for MED22 Gene

MGI Knock Outs for MED22:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED22 Gene

Localization for MED22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED22 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MED22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 8586415
GO:0016592 mediator complex IDA,IEA 14638676
genes like me logo Genes that share ontologies with MED22: view

Pathways & Interactions for MED22 Gene

genes like me logo Genes that share pathways with MED22: view

Gene Ontology (GO) - Biological Process for MED22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MED22: view

No data available for SIGNOR curated interactions for MED22 Gene

Drugs & Compounds for MED22 Gene

No Compound Related Data Available

Transcripts for MED22 Gene

Unigene Clusters for MED22 Gene

Mediator complex subunit 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED22

Alternative Splicing Database (ASD) splice patterns (SP) for MED22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -

Relevant External Links for MED22 Gene

GeneLoc Exon Structure for
MED22
ECgene alternative splicing isoforms for
MED22

Expression for MED22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.0), Pancreas (12.2), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED22 Gene



Protein tissue co-expression partners for MED22 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED22 Gene:

MED22

SOURCE GeneReport for Unigene cluster for MED22 Gene:

Hs.78354

Evidence on tissue expression from TISSUES for MED22 Gene

  • Nervous system(4.8)
  • Muscle(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with MED22: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED22 Gene

Orthologs for MED22 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED22 34 35
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia MED22 34 35
  • 91.5 (n)
cow
(Bos Taurus)
Mammalia MED22 34 35
  • 90.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED22 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med22 34 16 35
  • 89.95 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911917 34
  • 88.78 (n)
oppossum
(Monodelphis domestica)
Mammalia MED22 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED22 34 35
  • 80.16 (n)
lizard
(Anolis carolinensis)
Reptilia MED22 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med22 34
  • 70.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29396 34
zebrafish
(Danio rerio)
Actinopterygii med22 34 35
  • 77.18 (n)
Dr.15892 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4703 34
fruit fly
(Drosophila melanogaster)
Insecta MED22 34 35
  • 67.5 (n)
CG32971 35
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta MED22_ANOGA 34
  • 65.1 (n)
worm
(Caenorhabditis elegans)
Secernentea mdt-22 35
  • 31 (a)
OneToOne
Species where no ortholog for MED22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED22 Gene

ENSEMBL:
Gene Tree for MED22 (if available)
TreeFam:
Gene Tree for MED22 (if available)

Paralogs for MED22 Gene

(1) SIMAP similar genes for MED22 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MED22: view

No data available for Paralogs for MED22 Gene

Variants for MED22 Gene

Sequence variations from dbSNP and Humsavar for MED22 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000034576 -- 133,342,782(+) TGTTG(A/G)GGGAG intron-variant, utr-variant-3-prime
rs1000171207 -- 133,346,889(+) CCTTT(G/T)CCAGA intron-variant, upstream-variant-2KB
rs1000438055 -- 133,347,855(+) CACCC(A/C)CCCAC intron-variant, upstream-variant-2KB
rs1000861174 -- 133,347,994(+) CTCTG(C/T)GACCC upstream-variant-2KB, utr-variant-5-prime
rs1001079473 -- 133,347,738(+) TCTGG(A/C)GCACG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MED22 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
esv3621939 CNV loss 21293372
nsv1125319 OTHER inversion 24896259

Variation tolerance for MED22 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED22 Gene

Disorders for MED22 Gene

Relevant External Links for MED22

Genetic Association Database (GAD)
MED22
Human Genome Epidemiology (HuGE) Navigator
MED22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED22

No disorders were found for MED22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED22 Gene

Publications for MED22 Gene

  1. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. (PMID: 11891058) Angiolillo A. … Pietropaolo C. (Gene 2002) 3 4 22 64
  2. Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene. (PMID: 8586415) Garson K. … Fried M. (Genomics 1995) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 64
  5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 64

Products for MED22 Gene

  • Addgene plasmids for MED22

Sources for MED22 Gene

Content
Loading form....