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Aliases for MED21 Gene

Aliases for MED21 Gene

  • Mediator Complex Subunit 21 2 3 4 5
  • RNA Polymerase II Holoenzyme Component SRB7 3 4
  • RNAPII Complex Component SRB7 3 4
  • SURB7 3 4
  • HSrb7 3 4
  • SRB7 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 21 3
  • SRB7 (Suppressor Of RNA Polymerase B, Yeast) Homolog 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog (Yeast) 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog 3

External Ids for MED21 Gene

Previous HGNC Symbols for MED21 Gene

  • SURB7

Previous GeneCards Identifiers for MED21 Gene

  • GC12P027067
  • GC12P027175
  • GC12P026945

Summaries for MED21 Gene

Entrez Gene Summary for MED21 Gene

  • This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for MED21 Gene

MED21 (Mediator Complex Subunit 21) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include transcription coactivator activity and DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for MED21 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED21 Gene

Genomics for MED21 Gene

Regulatory Elements for MED21 Gene

Enhancers for MED21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F027021 1.1 ENCODE 24.6 +0.2 207 2.2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 NFYC MED21 LOC729222 ENSG00000247903 C12orf71 ENSG00000275764
GH12F027079 0.9 Ensembl ENCODE 28.6 +58.7 58668 2.8 CTCF ZNF146 RFX1 ZFP64 EBF1 ZNF781 RAD21 ZNF518A ZNF316 PRDM12 MED21 ENSG00000247903 C12orf71 LOC101928625
GH12F027176 1.7 FANTOM5 Ensembl ENCODE 13.6 +156.7 156679 5.6 HDGF ATF1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF48 GLIS2 ELK1 STK38L MED21 ENSG00000247903 MANSC4 C12orf71 PIR36462 ENSG00000256226
GH12F027064 0.8 Ensembl ENCODE 28.4 +42.2 42218 1.1 ZNF316 MTA2 IKZF1 HLF MLLT1 MAFK SPI1 MED21 ENSG00000247903 TM7SF3 C12orf71 LOC101928625
GH12F027190 1.4 FANTOM5 Ensembl ENCODE 14.7 +170.5 170462 5.2 INSM2 FEZF1 ZNF366 SCRT2 ZNF391 FOS CREM ZNF362 CEBPB ZEB2 MED21 ENSG00000247903 STK38L TM7SF3 PIR36462 PIR54993
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED21 on UCSC Golden Path with GeneCards custom track

Promoters for MED21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087494 278 2001 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A ZNF2 YY1 SP3 NFYC ZHX2

Genomic Location for MED21 Gene

Chromosome:
12
Start:
27,022,522 bp from pter
End:
27,066,343 bp from pter
Size:
43,822 bases
Orientation:
Plus strand

Genomic View for MED21 Gene

Genes around MED21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED21 Gene

Proteins for MED21 Gene

  • Protein details for MED21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13503-MED21_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 21
    Protein Accession:
    Q13503
    Secondary Accessions:
    • B2R4I3
    • Q6IB05
    • Q92811

    Protein attributes for MED21 Gene

    Size:
    144 amino acids
    Molecular mass:
    15564 Da
    Quaternary structure:
    • Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion.

neXtProt entry for MED21 Gene

Post-translational modifications for MED21 Gene

  • Ubiquitination at Lys 131
  • Modification sites at PhosphoSitePlus

Other Protein References for MED21 Gene

No data available for DME Specific Peptides for MED21 Gene

Domains & Families for MED21 Gene

Gene Families for MED21 Gene

Protein Domains for MED21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13503

UniProtKB/Swiss-Prot:

MED21_HUMAN :
  • Belongs to the Mediator complex subunit 21 family.
Family:
  • Belongs to the Mediator complex subunit 21 family.
genes like me logo Genes that share domains with MED21: view

Function for MED21 Gene

Molecular function for MED21 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IBA --
GO:0003713 transcription coactivator activity IDA 12037571
GO:0003899 DNA-directed RNA polymerase activity TAS 8598913
GO:0005515 protein binding IPI 14638676
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MED21: view
genes like me logo Genes that share phenotypes with MED21: view

Animal Models for MED21 Gene

MGI Knock Outs for MED21:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED21

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED21 Gene

Localization for MED21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED21 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IDA 12037571
genes like me logo Genes that share ontologies with MED21: view

Pathways & Interactions for MED21 Gene

genes like me logo Genes that share pathways with MED21: view

Gene Ontology (GO) - Biological Process for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8598913
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED21: view

No data available for SIGNOR curated interactions for MED21 Gene

Transcripts for MED21 Gene

Unigene Clusters for MED21 Gene

Mediator complex subunit 21:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED21 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5
SP1: - - -
SP2: -
SP3:
SP4: - -

Relevant External Links for MED21 Gene

GeneLoc Exon Structure for
MED21
ECgene alternative splicing isoforms for
MED21

Expression for MED21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MED21 Gene

Protein differential expression in normal tissues from HIPED for MED21 Gene

This gene is overexpressed in Pancreas (35.7), Bone (14.0), and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED21 Gene



NURSA nuclear receptor signaling pathways regulating expression of MED21 Gene:

MED21

SOURCE GeneReport for Unigene cluster for MED21 Gene:

Hs.286145
genes like me logo Genes that share expression patterns with MED21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MED21 Gene

Orthologs for MED21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED21 34 35
  • 99.77 (n)
oppossum
(Monodelphis domestica)
Mammalia MED21 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED21 34 35
  • 94.68 (n)
-- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MED21 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED21 34 35
  • 92.82 (n)
mouse
(Mus musculus)
Mammalia Med21 34 16 35
  • 92.82 (n)
rat
(Rattus norvegicus)
Mammalia Med21 34
  • 92.13 (n)
chicken
(Gallus gallus)
Aves MED21 34 35
  • 81.25 (n)
lizard
(Anolis carolinensis)
Reptilia MED21 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med21 34
  • 71.53 (n)
Str.17613 34
zebrafish
(Danio rerio)
Actinopterygii med21 34 35
  • 74.88 (n)
wufk48d02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1468 34
fruit fly
(Drosophila melanogaster)
Insecta MED21 34 35
  • 60.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta MED21_ANOGA 34
  • 56.07 (n)
worm
(Caenorhabditis elegans)
Secernentea mdt-21 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
Species where no ortholog for MED21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED21 Gene

ENSEMBL:
Gene Tree for MED21 (if available)
TreeFam:
Gene Tree for MED21 (if available)

Paralogs for MED21 Gene

Pseudogenes.org Pseudogenes for MED21 Gene

genes like me logo Genes that share paralogs with MED21: view

No data available for Paralogs for MED21 Gene

Variants for MED21 Gene

Sequence variations from dbSNP and Humsavar for MED21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1042833 -- 27,029,405(+) TTGAG(C/T)CTACT nc-transcript-variant, utr-variant-3-prime
rs11048819 -- 27,023,192(+) CATCT(C/G)TTGCC intron-variant
rs11048820 -- 27,024,214(+) TCTGA(C/T)TGTGA intron-variant
rs11048821 -- 27,029,818(+) ACTTA(C/T)TCAAA nc-transcript-variant, utr-variant-3-prime
rs11048822 -- 27,030,789(+) CATTT(C/T)GATTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MED21 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV deletion 23290073

Variation tolerance for MED21 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED21 Gene

Disorders for MED21 Gene

Relevant External Links for MED21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED21

No disorders were found for MED21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED21 Gene

Publications for MED21 Gene

  1. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PMID: 9734358) Sun X. … Reinberg D. (Mol. Cell 1998) 3 4 22 64
  2. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. (PMID: 8598913) Chao D.M. … Young R.A. (Nature 1996) 2 3 4 64
  3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 64
  4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4 64
  5. hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. (PMID: 15249124) Nevado J. … Aranda A. (Mol. Cell. Endocrinol. 2004) 3 4 64

Products for MED21 Gene

Sources for MED21 Gene

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