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Aliases for MED21 Gene

Aliases for MED21 Gene

  • Mediator Complex Subunit 21 2 3 4 5
  • RNA Polymerase II Holoenzyme Component SRB7 3 4
  • RNAPII Complex Component SRB7 3 4
  • SURB7 3 4
  • HSrb7 3 4
  • SRB7 3 4
  • SRB7 (Suppressor Of RNA Polymerase B, Yeast) Homolog 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog (Yeast) 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog 3

External Ids for MED21 Gene

Previous HGNC Symbols for MED21 Gene

  • SURB7

Previous GeneCards Identifiers for MED21 Gene

  • GC12P027067
  • GC12P027175
  • GC12P026945

Summaries for MED21 Gene

Entrez Gene Summary for MED21 Gene

  • This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for MED21 Gene

MED21 (Mediator Complex Subunit 21) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Developmental Biology. GO annotations related to this gene include transcription coactivator activity and DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for MED21 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED21 Gene

Genomics for MED21 Gene

Regulatory Elements for MED21 Gene

Enhancers for MED21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MED21 on UCSC Golden Path with GeneCards custom track

Promoters for MED21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED21 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED21 Gene

Chromosome:
12
Start:
27,022,522 bp from pter
End:
27,066,343 bp from pter
Size:
43,822 bases
Orientation:
Plus strand

Genomic View for MED21 Gene

Genes around MED21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED21 Gene

Proteins for MED21 Gene

  • Protein details for MED21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13503-MED21_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 21
    Protein Accession:
    Q13503
    Secondary Accessions:
    • B2R4I3
    • Q6IB05
    • Q92811

    Protein attributes for MED21 Gene

    Size:
    144 amino acids
    Molecular mass:
    15564 Da
    Quaternary structure:
    • Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion.

neXtProt entry for MED21 Gene

Proteomics data for MED21 Gene at MOPED

Post-translational modifications for MED21 Gene

  • Ubiquitination at Lys 131
  • Modification sites at PhosphoSitePlus

Other Protein References for MED21 Gene

No data available for DME Specific Peptides for MED21 Gene

Domains & Families for MED21 Gene

Gene Families for MED21 Gene

Protein Domains for MED21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13503

UniProtKB/Swiss-Prot:

MED21_HUMAN :
  • Belongs to the Mediator complex subunit 21 family.
Family:
  • Belongs to the Mediator complex subunit 21 family.
genes like me logo Genes that share domains with MED21: view

Function for MED21 Gene

Molecular function for MED21 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity TAS 8598913
genes like me logo Genes that share ontologies with MED21: view
genes like me logo Genes that share phenotypes with MED21: view

Animal Models for MED21 Gene

MGI Knock Outs for MED21:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED21 Gene

Localization for MED21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED21 Gene COMPARTMENTS Subcellular localization image for MED21 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IEA,IDA 12037571
genes like me logo Genes that share ontologies with MED21: view

Pathways & Interactions for MED21 Gene

genes like me logo Genes that share pathways with MED21: view

Gene Ontology (GO) - Biological Process for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0019827 stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with MED21: view

No data available for SIGNOR curated interactions for MED21 Gene

Drugs & Compounds for MED21 Gene

No Compound Related Data Available

Transcripts for MED21 Gene

Unigene Clusters for MED21 Gene

Mediator complex subunit 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED21 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5
SP1: - - -
SP2: -
SP3:
SP4: - -

Relevant External Links for MED21 Gene

GeneLoc Exon Structure for
MED21
ECgene alternative splicing isoforms for
MED21

Expression for MED21 Gene

mRNA expression in normal human tissues for MED21 Gene

Protein differential expression in normal tissues from HIPED for MED21 Gene

This gene is overexpressed in Pancreas (35.7), Bone (14.0), and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED21 Gene



SOURCE GeneReport for Unigene cluster for MED21 Gene Hs.286145

genes like me logo Genes that share expression patterns with MED21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MED21 Gene

Orthologs for MED21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED21 35
  • 92.82 (n)
  • 98.61 (a)
MED21 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED21 35
  • 94.68 (n)
  • 99.31 (a)
-- 36
  • 70 (a)
OneToMany
MED21 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Med21 35
  • 92.82 (n)
  • 97.92 (a)
Med21 16
Med21 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED21 35
  • 99.77 (n)
  • 100 (a)
MED21 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med21 35
  • 92.13 (n)
  • 98.61 (a)
oppossum
(Monodelphis domestica)
Mammalia MED21 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED21 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED21 35
  • 81.25 (n)
  • 95.14 (a)
MED21 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED21 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med21 35
  • 71.53 (n)
  • 86.11 (a)
Str.17613 35
zebrafish
(Danio rerio)
Actinopterygii med21 35
  • 74.88 (n)
  • 88.03 (a)
wufk48d02 35
med21 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1468 35
African malaria mosquito
(Anopheles gambiae)
Insecta MED21_ANOGA 35
  • 56.07 (n)
  • 59.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED21 35
  • 60.32 (n)
  • 61.9 (a)
MED21 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-21 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for MED21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED21 Gene

ENSEMBL:
Gene Tree for MED21 (if available)
TreeFam:
Gene Tree for MED21 (if available)

Paralogs for MED21 Gene

Pseudogenes.org Pseudogenes for MED21 Gene

genes like me logo Genes that share paralogs with MED21: view

No data available for Paralogs for MED21 Gene

Variants for MED21 Gene

Sequence variations from dbSNP and Humsavar for MED21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs8628 -- 27,028,580(+) CACAT(G/T)ACCTT nc-transcript-variant, utr-variant-3-prime
rs7298467 -- 27,020,960(+) GATTA(C/T)AGTAA upstream-variant-2KB
rs12829295 -- 27,030,371(+) ctcaa(A/G)ATATT nc-transcript-variant, utr-variant-3-prime
rs17487041 -- 27,029,836(+) AGTAT(C/T)ATAAA nc-transcript-variant, utr-variant-3-prime
rs11048819 -- 27,023,192(+) CATCT(C/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED21 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073

Variation tolerance for MED21 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MED21 Gene

Disorders for MED21 Gene

Relevant External Links for MED21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED21

No disorders were found for MED21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED21 Gene

Publications for MED21 Gene

  1. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. (PMID: 8598913) Chao D.M. … Young R.A. (Nature 1996) 2 3 4 67
  2. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PMID: 9734358) Sun X. … Reinberg D. (Mol. Cell 1998) 3 23
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3

Products for MED21 Gene

Sources for MED21 Gene

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