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Aliases for MED21 Gene

Aliases for MED21 Gene

  • Mediator Complex Subunit 21 2 3 4
  • SURB7 3 4 6
  • SRB7 3 4 6
  • RNA Polymerase II Holoenzyme Component SRB7 3 4
  • RNAPII Complex Component SRB7 3 4
  • HSrb7 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 21 3
  • SRB7 (Suppressor Of RNA Polymerase B, Yeast) Homolog 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog (Yeast) 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog 3

External Ids for MED21 Gene

Previous HGNC Symbols for MED21 Gene

  • SURB7

Previous GeneCards Identifiers for MED21 Gene

  • GC12P027067
  • GC12P027175
  • GC12P026945

Summaries for MED21 Gene

Entrez Gene Summary for MED21 Gene

  • This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for MED21 Gene

MED21 (Mediator Complex Subunit 21) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transcription coactivator activity and DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for MED21 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED21 Gene

Genomics for MED21 Gene

Regulatory Elements for MED21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED21 Gene

Start:
27,022,522 bp from pter
End:
27,066,343 bp from pter
Size:
43,822 bases
Orientation:
Plus strand

Genomic View for MED21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED21 Gene

Proteins for MED21 Gene

  • Protein details for MED21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13503-MED21_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 21
    Protein Accession:
    Q13503
    Secondary Accessions:
    • B2R4I3
    • Q6IB05
    • Q92811

    Protein attributes for MED21 Gene

    Size:
    144 amino acids
    Molecular mass:
    15564 Da
    Quaternary structure:
    • Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion.

neXtProt entry for MED21 Gene

Proteomics data for MED21 Gene at MOPED

Post-translational modifications for MED21 Gene

  • Ubiquitination at Lys131
  • Modification sites at PhosphoSitePlus

Other Protein References for MED21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MED21 Gene

Domains for MED21 Gene

Protein Domains for MED21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13503

UniProtKB/Swiss-Prot:

MED21_HUMAN :
  • Q13503
Family:
  • Belongs to the Mediator complex subunit 21 family.
genes like me logo Genes that share domains with MED21: view

No data available for Gene Families for MED21 Gene

Function for MED21 Gene

Molecular function for MED21 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 12037571
GO:0003899 DNA-directed RNA polymerase activity TAS 8598913
GO:0005515 protein binding IPI 14638676
genes like me logo Genes that share ontologies with MED21: view

Phenotypes for MED21 Gene

MGI mutant phenotypes for MED21:
inferred from 1 alleles
GenomeRNAi human phenotypes for MED21:
genes like me logo Genes that share phenotypes with MED21: view

Animal Models for MED21 Gene

MGI Knock Outs for MED21:

Animal Model Products

CRISPR Products

miRNA for MED21 Gene

miRTarBase miRNAs that target MED21

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MED21 Gene

Localization for MED21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED21 Gene COMPARTMENTS Subcellular localization image for MED21 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IDA 12037571
genes like me logo Genes that share ontologies with MED21: view

Pathways for MED21 Gene

genes like me logo Genes that share pathways with MED21: view

Gene Ontology (GO) - Biological Process for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8598913
GO:0019827 stem cell maintenance IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12037571
genes like me logo Genes that share ontologies with MED21: view

Transcripts for MED21 Gene

Unigene Clusters for MED21 Gene

Mediator complex subunit 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED21

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED21 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5
SP1: - - -
SP2: -
SP3:
SP4: - -

Relevant External Links for MED21 Gene

GeneLoc Exon Structure for
MED21
ECgene alternative splicing isoforms for
MED21

Expression for MED21 Gene

mRNA expression in normal human tissues for MED21 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED21 Gene

SOURCE GeneReport for Unigene cluster for MED21 Gene Hs.286145

genes like me logo Genes that share expressions with MED21: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED21 Gene

Orthologs for MED21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED21 35
  • 99.77 (n)
  • 100 (a)
MED21 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED21 35
  • 92.82 (n)
  • 98.61 (a)
MED21 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
MED21 35
  • 94.68 (n)
  • 99.31 (a)
MED21 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Med21 35
  • 92.82 (n)
  • 97.92 (a)
Med21 16
Med21 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED21 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED21 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med21 35
  • 92.13 (n)
  • 98.61 (a)
chicken
(Gallus gallus)
Aves MED21 35
  • 81.25 (n)
  • 95.14 (a)
MED21 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED21 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med21 35
  • 71.53 (n)
  • 86.11 (a)
Str.17613 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1468 35
zebrafish
(Danio rerio)
Actinopterygii med21 35
  • 74.88 (n)
  • 88.03 (a)
med21 36
  • 86 (a)
OneToOne
wufk48d02 35
African malaria mosquito
(Anopheles gambiae)
Insecta MED21_ANOGA 35
  • 56.07 (n)
  • 59.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED21 35
  • 60.32 (n)
  • 61.9 (a)
MED21 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-21 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for MED21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED21 Gene

ENSEMBL:
Gene Tree for MED21 (if available)
TreeFam:
Gene Tree for MED21 (if available)

Paralogs for MED21 Gene

Pseudogenes.org Pseudogenes for MED21 Gene

genes like me logo Genes that share paralogs with MED21: view

No data available for Paralogs for MED21 Gene

Variants for MED21 Gene

Sequence variations from dbSNP and Humsavar for MED21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8628 -- 27,028,580(+) CACAT(G/T)ACCTT utr-variant-3-prime, nc-transcript-variant
rs1042833 -- 27,029,405(+) TTGAG(C/T)CTACT utr-variant-3-prime, nc-transcript-variant
rs1872191 -- 27,022,707(+) ACTTG(A/G)AAGTG intron-variant, nc-transcript-variant
rs1872193 -- 27,028,866(+) AGTTT(A/G)GGCTA utr-variant-3-prime, nc-transcript-variant
rs3782317 -- 27,020,705(+) GACTA(C/T)ATTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MED21 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073

Relevant External Links for MED21 Gene

HapMap Linkage Disequilibrium report
MED21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED21 Gene

Disorders for MED21 Gene

No disorders were found for MED21 Gene.

No data available for UniProtKB/Swiss-Prot for MED21 Gene

Publications for MED21 Gene

  1. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. (PMID: 8598913) Chao D.M. … Young R.A. (Nature 1996) 2 3 4
  2. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PMID: 9734358) Sun X. … Reinberg D. (Mol. Cell 1998) 3 4 23
  3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4
  4. hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. (PMID: 15249124) Nevado J. … Aranda A. (Mol. Cell. Endocrinol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MED21 Gene

Sources for MED21 Gene

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