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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED21 Gene

protein-coding   GIFtS: 53
GCID: GC12P027175

Mediator Complex Subunit 21

(Previous names: SRB7 (suppressor of RNA polymerase B, yeast) homolog, SRB7...)
(Previous symbol: SURB7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 211 2 3     RNAPII Complex Component SRB72 3
SURB71 2 3 5     SRB7 (Suppressor Of RNA Polymerase B, Yeast) Homolog1
SRB72 3 5     SRB7 Suppressor Of RNA Polymerase B Homolog (Yeast)1
hSrb72 3     Mediator Of RNA Polymerase II Transcription Subunit 212
RNA Polymerase II Holoenzyme Component SRB72 3     SRB7 Suppressor Of RNA Polymerase B Homolog2

External Ids:    HGNC: 114731   Entrez Gene: 94122   Ensembl: ENSG000001529447   OMIM: 6038005   UniProtKB: Q135033   

Export aliases for MED21 gene to outside databases

Previous GC identifers: GC12P027067 GC12P026945


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED21 Gene:
This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human
RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed
genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for MED21 Gene: 
MED21 (mediator complex subunit 21) is a protein-coding gene. Diseases associated with MED21 include pancreatic cancer, and pancreatitis, and among its related super-pathways are Axon guidance and Transcription Ligand-Dependent Transcription of Retinoid-Target genes. GO annotations related to this gene include DNA-directed RNA polymerase activity and transcription coactivator activity.

UniProtKB/Swiss-Prot: MED21_HUMAN, Q13503
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED21 gene promoter:
         AhR   AML1a   POU2F1   POU2F1a   Nkx2-5   Arnt   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED21 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.23   Ensembl cytogenetic band:  12p11.23   HGNC cytogenetic band: 12p12

MED21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED21 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P027175:  view genomic region     (about GC identifiers)

Start:
27,175,479 bp from pter      End:
27,219,276 bp from pter
Size:
43,798 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED21_HUMAN, Q13503 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 21  
Size: 144 amino acids; 15564 Da
Subunit: Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4,
MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20,
MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12,
MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module
is less active than Mediator lacking this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP,
DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion
Subcellular location: Nucleus (Probable)
Secondary accessions: B2R4I3 Q6IB05 Q92811

Explore the universe of human proteins at neXtProt for MED21: NX_Q13503

Explore proteomics data for MED21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13503

  • MED21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED21 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258740.1  NP_004255.2  

    ENSEMBL proteins: 
     ENSP00000442126   ENSP00000282892   ENSP00000444297  
    Reactome Protein details: Q13503
    Human Recombinant Protein Products for MED21: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED21
    OriGene Protein Over-expression Lysate for MED21
    OriGene MassSpec for MED21 
    OriGene Custom Protein Services for MED21
    GenScript Custom Purified and Recombinant Proteins Services for MED21
    Novus Biologicals MED21 Proteins
    Novus Biologicals MED21 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED21 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016592mediator complex IDA12037571

    MED21 for ontologies           About GeneDecksing



    MED21 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MED21 Antibodies
    Abcam antibodies for MED21
    Cloud-Clone Corp. Antibodies for MED21 
    Search ThermoFisher Antibodies for MED21
    LSBio Antibodies in human, mouse, rat for MED21 

    Assay Products for MED21: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED21
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED21
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED21 
    Cloud-Clone Corp. CLIAs for MED21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR021384 Mediator_Med21

    Graphical View of Domain Structure for InterPro Entry Q13503

    ProtoNet protein and cluster: Q13503

    UniProtKB/Swiss-Prot: MED21_HUMAN, Q13503
    Similarity: Belongs to the Mediator complex subunit 21 family


    MED21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED21_HUMAN, Q13503
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA12037571
    GO:0003899DNA-directed RNA polymerase activity TAS8598913
    GO:0005515protein binding ----
         
    MED21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MED21:
     Increased S DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Med21):
     mortality/aging 

    MED21 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Med21tm1Ryng for MED21

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED21 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED21
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MED21 (see all 10):
    hsa-miR-577 hsa-miR-2052 hsa-miR-320a hsa-miR-320d hsa-miR-335 hsa-miR-548m hsa-miR-320b hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidMED21 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED21
    Sirion Biotech Customized adenovirus for overexpression of MED21

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED21 (see all 7)
    OriGene ORF clones in mouse, rat for MED21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED21 (NM_004264)
    Sino Biological Human cDNA Clone for MED21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED21
    Sirion Biotech Customized lentivirus for stable overexpression of MED21 
                         Customized lentivirus expression plasmids for stable overexpression of MED21 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED21
    Search LifeMap BioReagents cell lines for MED21
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    3Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED21
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED21
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    2        Reactome Pathways for MED21
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation



    MED21 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/116 Interacting proteins for MED21 (Q135033 ENSP000002828924) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2H4Q927593, ENSP000002598954I2D: score=1 STRING: ENSP00000259895
    ENSG00000221974Q927593I2D: score=1 
    ENSG00000226384Q927593I2D: score=1 
    ENSG00000233149Q927593I2D: score=1 
    ENSG00000234370Q927593I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8598913
    GO:0019827stem cell maintenance IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12037571

    MED21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED21

    Search CenterWatch for drugs/clinical trials and news about MED21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED21 gene (2 alternative transcripts): 
    NM_001271811.1  NM_004264.4  

    Unigene Cluster for MED21:

    Mediator complex subunit 21
    Hs.286145  [show with all ESTs]
    Unigene Representative Sequence: NR_073464
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546323 ENST00000536503 ENST00000282892(uc001rhp.1 uc009zjh.1)
    ENST00000536711 ENST00000538186 ENST00000544998
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED21
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MED21 (see all 10):
    hsa-miR-577 hsa-miR-2052 hsa-miR-320a hsa-miR-320d hsa-miR-335 hsa-miR-548m hsa-miR-320b hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidMED21 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED21
    Clone
    Products:
         
    OriGene clones in human, mouse for MED21 (see all 7)
    OriGene ORF clones in mouse, rat for MED21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED21 (NM_004264)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED21
    Sirion Biotech Customized lentivirus for stable overexpression of MED21 
                         Customized lentivirus expression plasmids for stable overexpression of MED21 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED21
    OriGene qSTAR qPCR primer pairs in human, mouse for MED21
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED21
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED21

    Additional mRNA sequence: 

    AK309064.1 AK311838.1 BC008380.1 CR456999.1 NR_073463.1 NR_073464.1 U46837.1 U52960.1 

    10 DOTS entries:

    DT.75184631  DT.95321003  DT.121142075  DT.121142068  DT.121142069  DT.121142072  DT.121142070  DT.40203905 
    DT.92430897  DT.121142064 

    24/191 AceView cDNA sequences (see all 191):

    AA370665 AL573000 BU728538 AL548435 CR593127 F13227 BU661021 BM920061 
    BU169702 CA310755 AA314508 CR621668 AA449639 F10828 AW341584 AA449476 
    AA449905 BM993369 AW613125 T17234 AI961119 AA450370 BQ879565 BQ017440 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MED21    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5
    SP1:                    -                             -     -         
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                    -     -                                       


    ECgene alternative splicing isoforms for MED21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATACATTA
    MED21 Expression
    About this image


    See MED21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED21

    SOURCE GeneReport for Unigene cluster: Hs.286145
        SABiosciences Custom PCR Arrays for MED21
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED21
    OriGene qSTAR qPCR primer pairs in human, mouse for MED21
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED21
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED21
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED21 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med211 , 5 mediator complex subunit 211, 5 92.82(n)1
    97.92(a)1
      6 (77.70 cM)5
    1080981  NM_025315.31  NP_079591.11 
     1466425475 
    chicken
    (Gallus gallus)
    Aves MED211 mediator complex subunit 21 81.25(n)
    95.14(a)
      418216  XM_416442.3  XP_416442.2 
    lizard
    (Anolis carolinensis)
    Reptilia MED216
    Uncharacterized protein
    91(a)
    1 ↔ 1
    5(91143422-91149863)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX852945.12   -- 73.12(n)    BX852945.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk48d022 Danio rerio mRNA similar to SRB7 suppressor of RNA more 78.25(n)    BC049042.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED211 Mediator complex subunit 21 60.32(n)
    61.9(a)
      3354977  NM_001015224.2  NP_001015224.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-216
    Mediator of RNA polymerase II transcription subuni...
    37(a)
    1 ↔ 1
    III(11777644-11779444)


    ENSEMBL Gene Tree for MED21 (if available)
    TreeFam Gene Tree for MED21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED21 gene

    MED21 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MED21
    PGOHUM00000260419


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/234 SNPs in MED21 are shown (see all 234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740726981,2
    C,F--27173488(+) GATTGG/AGGGGA 4 -- us2k12Minor allele frequency- A:0.08WA 120
    rs2018378371,2
    C--27173522(+) GGGAC-/AGGGAT 4 -- us2k10--------
    rs1862689601,2
    --27173593(+) AAAGTA/CAAGAG 4 -- us2k10--------
    rs37823171,2
    C,F,A--27173638(+) GACTAT/CATTTG 4 -- us2k15Minor allele frequency- C:0.13NA 128
    rs38251661,2
    C,F,H--27173690(+) CTAAAC/ACCCTT 4 -- us2k16Minor allele frequency- A:0.05EA NS NA 422
    rs1907918901,2
    --27173752(+) TTTATC/TTGATT 4 -- us2k10--------
    rs771090491,2
    C,F--27173770(+) AGATCC/TGTGGC 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs762445171,2
    C,F--27173824(+) TTGGCT/CGAAAC 4 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1447906471,2
    --27173833(+) ACAGAC/TTATTT 4 -- us2k10--------
    rs72984671,2
    C,F,A,H--27173893(+) GATTAT/CAGTAA 4 -- us2k1 tfbs324Minor allele frequency- C:0.19NS EA NA WA 2772

    HapMap Linkage Disequilibrium report for MED21 (27175479 - 27219276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MED21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745664CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MED21
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603800    OMIM disorders: --

    3 diseases for MED21:    About MalaCards
    pancreatic cancer    pancreatitis    thyroiditis


    MED21 for disorders           About GeneDecksing


    Export disorders for MED21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED21 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with MED21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. (PubMed id 8598913)1, 2, 3 Chao D.M.... Young R.A. (1996)
    2. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2, 9 Sun X.... Reinberg D. (1998)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    4. hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. (PubMed id 15249124)1, 2 Nevado J.... Aranda A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    7. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (1999)
    8. A human RNA polymerase II complex associated with SRB and DNA-repair proteins. (PubMed id 8609996)1, 2 Maldonado E.... Reinberg D. (1996)
    9. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    10. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13 L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9412 HGNC: 11473 AceView: SURB7 Ensembl:ENSG00000152944 euGenes: HUgn9412
    ECgene: MED21 H-InvDB: MED21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED21 gene:
    Search GeneIP for patents involving MED21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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