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MED20 Gene

protein-coding   GIFtS: 56
GCID: GC06M041877

Mediator Complex Subunit 20

(Previous name: Trf (TATA binding protein-related factor)-proximal homolog...)
(Previous symbol: TRFP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 201 2 3     PRO02132
TRFP1 2 3 5     Mediator Complex Subunit 20mediator Complex Subunit 20mediator Complex
Subunit 20Trf (TATA Binding Protein-Related Factor)-Proximal Homolog2
hTRFP2 3     Mediator Of RNA Polymerase II Transcription Subunit 202
TRF-Proximal Protein Homolog2 3     Trf (TATA Binding Protein-Related Factor)-Proximal Homolog2
Trf (TATA Binding Protein-Related Factor)-Proximal Homolog (Drosophila)1     

External Ids:    HGNC: 168401   Entrez Gene: 94772   Ensembl: ENSG000001246417   OMIM: 6129155   UniProtKB: Q9H9443   

Export aliases for MED20 gene to outside databases

Previous GC identifers: GC06M041983 GC06M041591


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED20 Gene:
MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with
DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et
al., 2003 (PubMed 14576168)).(supplied by OMIM, Aug 2009)

GeneCards Summary for MED20 Gene:
MED20 (mediator complex subunit 20) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: MED20_HUMAN, Q9H944
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED20 gene promoter:
         AhR   C/EBPbeta   Sp1   p53   AML1a   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED20 promoter sequence
   Search Chromatin IP Primers for MED20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

MED20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED20 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041877:  view genomic region     (about GC identifiers)

Start:
41,873,092 bp from pter      End:
41,888,877 bp from pter
Size:
15,786 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MED20_HUMAN, Q9H944 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 20  
Size: 212 amino acids; 23222 Da
Subunit: Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4,
MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20,
MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12,
MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module
is less active than Mediator lacking this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP,
DRIP, PC2, SMCC and TRAP
Secondary accessions: O95821 Q5T8J4 Q9Y429

Explore the universe of human proteins at neXtProt for MED20: NX_Q9H944

Explore proteomics data for MED20 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MED20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004266.2  
    ENSEMBL proteins: 
     ENSP00000265350   ENSP00000386816   ENSP00000377795   ENSP00000386668   ENSP00000403061  
    Reactome Protein details: Q9H944

    MED20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED20
    OriGene Protein Over-expression Lysate for MED20
    OriGene MassSpec for MED20
    OriGene Custom Protein Services for MED20
    GenScript Custom Purified and Recombinant Proteins Services for MED20
    Novus Biologicals MED20 Proteins
    Novus Biologicals MED20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MED20
    Cloud-Clone Corp. Proteins for MED20

     
    Search eBioscience for Proteins for MED20 

    MED20 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED20
    Novus Biologicals MED20 Antibodies
    Abcam antibodies for MED20
    Cloud-Clone Corp. Antibodies for MED20
    Search ThermoFisher Antibodies for MED20
    LSBio Antibodies in human, mouse, rat for MED20

    MED20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED20
    Cloud-Clone Corp. CLIAs for MED20
    Search eBioscience for ELISAs for MED20 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013921 Mediator_Med20

    Graphical View of Domain Structure for InterPro Entry Q9H944

    ProtoNet protein and cluster: Q9H944

    1 Blocks protein domain: IPB013921 TATA-binding related factor

    UniProtKB/Swiss-Prot: MED20_HUMAN, Q9H944
    Similarity: Belongs to the Mediator complex subunit 20 family


    Find genes that share domains with MED20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED20_HUMAN, Q9H944
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003899DNA-directed RNA polymerase activity NAS9933582
    GO:0005515protein binding IPI14576168
         
    Find genes that share ontologies with MED20           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED20

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED20:
    hsa-mir-124-3p (MIRT022390)

    Block miRNA regulation of human, mouse, rat MED20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED20 (see all 10):
    hsa-miR-3679-3p hsa-miR-676 hsa-miR-615-5p hsa-miR-526b hsa-miR-4268 hsa-miR-545 hsa-miR-1224-5p hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidMED20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED20
    Predesigned siRNA for gene silencing in human, mouse, rat MED20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED20

    Clone
    Products:
         
    OriGene clones in human, mouse for MED20 (see all 6)
    OriGene ORF clones in mouse, rat for MED20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED20 (NM_004275)
    Sino Biological Human cDNA Clone for MED20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED20

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED20
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED20_HUMAN, Q9H944: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytoskeleton1
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex NAS9933582

    Find genes that share ontologies with MED20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED20 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes


    Find genes that share SuperPaths with MED20           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MED20
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    3 Reactome Pathways for MED20
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED20
    Interactions:

        Search GeneGlobe Interaction Network for MED20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED20 (Q9H9441, 2, 3 ENSP000002653504) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED29Q9NX701, 2, 3, ENSP000003143434EBI-394644,EBI-394656 MINT-50494 I2D: score=5 STRING: ENSP00000314343
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    MED28Q9H2043, ENSP000002373804I2D: score=2 STRING: ENSP00000237380
    MED30Q96HR33, ENSP000002973474I2D: score=2 STRING: ENSP00000297347
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated NAS9933582
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9933582
    GO:0006366transcription from RNA polymerase II promoter TAS9933582
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with MED20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED20



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MED20 gene: 
    NM_004275.3  

    Unigene Cluster for MED20:

    Mediator complex subunit 20
    Hs.278434  [show with all ESTs]
    Unigene Representative Sequence: AK097385
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265350(uc003ork.3 uc011duh.2 uc011dui.2 uc011duj.2)
    ENST00000467535(uc003orj.3) ENST00000482361 ENST00000409312 ENST00000394251
    ENST00000409060 ENST00000434077
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED20 (see all 10):
    hsa-miR-3679-3p hsa-miR-676 hsa-miR-615-5p hsa-miR-526b hsa-miR-4268 hsa-miR-545 hsa-miR-1224-5p hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidMED20 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED20
    Predesigned siRNA for gene silencing in human, mouse, rat MED20
    Clone
    Products:
         
    OriGene clones in human, mouse for MED20 (see all 6)
    OriGene ORF clones in mouse, rat for MED20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED20 (NM_004275)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED20
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED20
    OriGene qSTAR qPCR primer pairs in human, mouse for MED20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED20
      QuantiTect SYBR Green Assays in human, mouse, rat MED20
      QuantiFast Probe-based Assays in human, mouse, rat MED20

    Additional mRNA sequence: 

    AF097725.1 AF116602.1 AJ420544.1 AK023092.1 AK097385.1 AK293412.1 AK300573.1 AK307070.1 
    AL050196.1 BC012618.1 BC015189.1 BC019866.1 BC032552.1 BC033498.1 BC040950.1 BC063509.1 

    14 DOTS entries:

    DT.414559  DT.100703150  DT.121342315  DT.100818594  DT.414560  DT.121342148  DT.100818593  DT.100818592 
    DT.92044269  DT.100718930  DT.121342202  DT.121342220  DT.91657458  DT.75125613 

    Selected AceView cDNA sequences (see all 226):

    BC033498 BM768061 BP379554 CA426795 BM771482 NM_018561 BM711328 BM770537 
    BM741449 CR603210 AF244998 AA694369 BQ670725 BM770675 BM747983 NM_004275 
    BM770783 BX090024 AI800301 BM766485 BC014176 BM767313 T30294 BC015189 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MED20 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
    SP1:                          -                       -                           
    SP2:                    -     -           -           -                           
    SP3:                    -     -           -     -     -                           
    SP4:                    -     -     -     -           -                           
    SP5:                    -     -           -                                       


    ECgene alternative splicing isoforms for MED20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MED20 Expression
    About this image


    MED20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    MED20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278434
        Custom PCR Arrays for MED20
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED20
    OriGene qSTAR qPCR primer pairs in human, mouse for MED20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED20
    QuantiTect SYBR Green Assays in human, mouse, rat MED20
    QuantiFast Probe-based Assays in human, mouse, rat MED20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED20 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med201 , 5 mediator complex subunit 201, 5 91.19(n)1
    97.17(a)1
      17 (23.66 cM)5
    567711  NM_020048.31  NP_064432.11 
     476115825 
    chicken
    (Gallus gallus)
    Aves MED201 mediator complex subunit 20 78.2(n)
    85.31(a)
      419926  NM_001006327.2  NP_001006327.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    85(a)
    80(a)
    many → 1
    many → 1
    4(119280581-119292506)
    1(17282031-17284887)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152052 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_004266.1 (H.sapiens) TRF-proximal protein [Homo sapiens] less 77.94(n)    BU911131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.237172 Transcribed sequence with weak similarity to protein pirT08801 (H.sapiens) T08801 hypothetical protein DKFZp586D2223.1 - human (fragment) less 72.24(n)    BI891068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED201 Mediator complex subunit 20 51.41(n)
    42.29(a)
      43952  NM_001273294.1  NP_001260223.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-201 mdt-20 47.7(n)
    35.64(a)
      176937  NM_067649.1  NP_500050.1 


    ENSEMBL Gene Tree for MED20 (if available)
    TreeFam Gene Tree for MED20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MED20 gene
    1 SIMAP similar gene for MED20 using alignment to 5 protein entries:     MED20_HUMAN (see all proteins):
    TRFP

    Find genes that share paralogs with MED20           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED20 (see all 298)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs570919301,2
    C,F--41872685(+) TGCACG/ATGCCT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1391511901,2
    --41872745(+) GGAAGC/TGGAGG 1 -- ds50010--------
    rs1424553671,2
    C--41872767(+) CAAGAC/TTGTAC 1 -- ds50010--------
    rs792628341,2
    C,F--41873104(+) TGTGCA/GTTTTA 1 -- ut310--------
    rs77595951,2
    C,F,H--41873221(+) GTACTG/TAACTG 1 -- ut31 ese310Minor allele frequency- T:0.04NS EA NA WA 1206
    rs1486077761,2
    C--41873531(+) AGCATA/GGTGCA 1 -- ut310--------
    rs1902778061,2
    --41873554(+) AAGTAC/TTCTAA 1 -- ut310--------
    rs1820466941,2
    C--41873573(+) TCAGGA/GTGCAT 1 -- ut310--------
    rs1420766261,2
    --41873641(+) TAGTGC/TGACTA 1 -- ut310--------
    rs2011047951,2
    C--41873736(-) ATTTTG/TCAGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MED20 (41873092 - 41888877 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5278CNV Insertion18451855
    nsv830646CNV Loss17160897

    Human Gene Mutation Database (HGMD): MED20
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED20
    DNA2.0 Custom Variant and Variant Library Synthesis for MED20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612915    OMIM disorders: --


    Find genes that share disorders with MED20           About GenesLikeMe

    Genetic Association Database (GAD): MED20

    Export disorders for MED20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED20 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MED20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S.... Conaway R.C. (Mol. Cell 2004)
    2. The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex. (PubMed id 9933582)1, 2, 3 Xiao H.... Roeder R.G. (J. Biol. Chem. 1999)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (J. Biol. Chem. 2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9477 HGNC: 16840 AceView: USP49andMGC20741 Ensembl:ENSG00000124641 euGenes: HUgn9477
    ECgene: MED20 H-InvDB: MED20

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MED20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MED20 gene:
    Search GeneIP for patents involving MED20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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