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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED20 Gene

protein-coding   GIFtS: 51
GCID: GC06M041877

mediator complex subunit 20

(Previous name: Trf (TATA binding protein-related factor)-proximal homolog...)
(Previous symbol: TRFP)
 Explore 2 diseases affiliated with
MED20 via our new
 Human Malady Compendium 
Biological research products
for MED20
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 201 2 3     DKFZp586D22231
TRFP1 2 3 5     Trf (TATA Binding Protein-Related Factor)-Proximal Homolog (Drosophila)1
PRO02131 2     Mediator Complex Subunit 20mediator Complex Subunit 20mediator Complex Subunit
20Trf (TATA Binding Protein-Related Factor)-Proximal Homolog2
HTRFP1     Mediator Of RNA Polymerase II Transcription Subunit 202
TRF-Proximal Protein Homolog2 3     Trf (TATA Binding Protein-Related Factor)-Proximal Homolog2

External Ids:    HGNC: 168401   Entrez Gene: 94772   Ensembl: ENSG000001246417   OMIM: 6129155   UniProtKB: Q9H9443   

Export aliases for MED20 gene to outside databases

Previous GC identifers: GC06M041983 GC06M041591


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED20:
MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with
DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al.,
2003 (PubMed 14576168)).(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: MED20_HUMAN, Q9H944
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED20 gene promoter:
         AhR   C/EBPbeta   Sp1   p53   AML1a   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED20 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

MED20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED20 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041877:  view genomic region     (about GC identifiers)

Start:
41,873,092 bp from pter      End:
41,888,877 bp from pter
Size:
15,786 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED20_HUMAN, Q9H944 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 20  
Size: 212 amino acids; 23222 Da
Subunit: Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4,
MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21,
MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and
CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than
Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex
lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Secondary accessions: O95821 Q5T8J4 Q9Y429

Explore the universe of human proteins at neXtProt for MED20: NX_Q9H944

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H944

  • MED20 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004266.2  
    ENSEMBL proteins: 
     ENSP00000265350   ENSP00000386816   ENSP00000377795   ENSP00000386668   ENSP00000403061  
    Reactome Protein details: Q9H944
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MED20
    OriGene Protein Over-expression Lysate: MED20
    OriGene Custom Protein Services for MED20 
    GenScript Custom Purified and Recombinant Proteins Services for MED20
    Novus Biologicals MED20 Protein
    Novus Biologicals MED20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED20

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex NAS9933582


    MED20 for ontologies           About GeneDecksing



    MED20 Antibody Products: 
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    Uscn ELISAs and CLIAs for MED20


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MED20 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013921 Mediator_Med20

    Graphical View of Domain Structure for InterPro Entry Q9H944

    ProtoNet protein and cluster: Q9H944

    1 Blocks protein family: IPB013921 TATA-binding related factor

    UniProtKB/Swiss-Prot: MED20_HUMAN, Q9H944
    Similarity: Belongs to the Mediator complex subunit 20 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MED20_HUMAN, Q9H944
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: MED20
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED20
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MED20 (see all 10):
    hsa-miR-3679-3p hsa-miR-676 hsa-miR-615-5p hsa-miR-526b hsa-miR-4268 hsa-miR-545 hsa-miR-1224-5p hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidMED20 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED20 (see all 4)
    OriGene shRNA RFP: MED20
    OriGene siRNA: MED20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED20

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED20 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED20
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED20 (NM_004275)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED20 

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    GenScript Custom overexpressing Cell Line Services for MED20
    Search LifeMap BioReagents cell lines for MED20

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED20

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0003899DNA-directed RNA polymerase activity NAS9933582
    GO:0005515protein binding IPI15175163


    MED20 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46
    2HIV Infection
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    3Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation1.00
    4Axon guidance
    Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MED20
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED20
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED20
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED20 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/91 Interacting proteins for MED20 (Q9H9441, 2, 3 ENSP000002653504) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED29Q9NX701, 2, 3, ENSP000003143434EBI-394644,EBI-394656 MINT-50494 I2D: score=5 STRING: ENSP00000314343
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    MED28Q9H2043, ENSP000002373804I2D: score=2 STRING: ENSP00000237380
    MED30Q96HR33, ENSP000002973474I2D: score=2 STRING: ENSP00000297347
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent NAS9933582
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9933582
    GO:0006366transcription from RNA polymerase II promoter TAS9933582
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--


    MED20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED20
    Search CenterWatch for drugs/clinical trials and news about MED20 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED20 gene: 
    NM_004275.3  

    Unigene Cluster for MED20:

    Mediator complex subunit 20
    Hs.278434  [show with all ESTs]
    Unigene Representative Sequence: AK097385
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265350(uc003ork.3 uc011duh.2 uc011dui.2 uc011duj.2)
    ENST00000467535(uc003orj.3) ENST00000482361 ENST00000409312 ENST00000394251
    ENST00000409060 ENST00000434077

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MED20
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED20
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MED20 (see all 10):
    hsa-miR-3679-3p hsa-miR-676 hsa-miR-615-5p hsa-miR-526b hsa-miR-4268 hsa-miR-545 hsa-miR-1224-5p hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidMED20 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED20 (see all 4)
    OriGene shRNA RFP: MED20
    OriGene siRNA: MED20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED20
    Clone
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    GenScript: all cDNA clones in your preferred vector: MED20 (NM_004275)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED20 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED20
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED20
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED20

    Additional cDNA sequence: 

    AF097725.1 AF116602.1 AJ420544.1 AK023092.1 AK097385.1 AK293412.1 AK300573.1 AK307070.1 
    AL050196.1 BC012618.1 BC015189.1 BC019866.1 BC032552.1 BC033498.1 BC040950.1 BC063509.1 

    14 DOTS entries:

    DT.414559  DT.100703150  DT.121342315  DT.100818594  DT.414560  DT.121342148  DT.100818593  DT.100818592 
    DT.92044269  DT.100718930  DT.121342202  DT.121342220  DT.91657458  DT.75125613 

    24/226 AceView cDNA sequences (see all 226):

    BC063509 NM_004275 BM767313 BM766485 BM661788 BM476769 BQ880980 BM770564 
    AA878004 AI140920 BQ712535 BM770903 BF727344 BM770675 BM800534 N54253 
    F13789 BC015189 AA353918 BM770783 BM772202 BM741933 AJ586139 BC033498 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MED20 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
    SP1:                          -                       -                           
    SP2:                    -     -           -           -                           
    SP3:                    -     -           -     -     -                           
    SP4:                    -     -     -     -           -                           
    SP5:                    -     -           -                                       


    ECgene alternative splicing isoforms for MED20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MED20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED20

    SOURCE GeneReport for Unigene cluster: Hs.278434
        SABiosciences Custom PCR Arrays for MED20
    Primer
    Products:
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED20 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med201 , 5 mediator complex subunit 201, 5 91.19(n)1
    97.17(a)1
      17 (23.66 cM)5
    567711  NM_020048.31  NP_064432.11 
     476115825 
    chicken
    (Gallus gallus)
    Aves MED201 mediator complex subunit 20 78.2(n)
    85.31(a)
      419926  NM_001006327.1  NP_001006327.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    85(a)
    80(a)
    many → 1
    many → 1
    4(119280581-119292506)
    1(17282031-17284887)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152052 Xenopus laevis transcribed sequence with moderate similarity more 77.94(n)    BU911131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.237172 Transcribed sequence with weak similarity to protein more 72.24(n)    BI891068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED201 Mediator complex subunit 20 51.33(n)
    42.5(a)
      43952  NM_079924.2  NP_524663.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-201 Protein MDT-20 47.7(n)
    35.64(a)
      176937  NM_067649.1  NP_500050.1 


    ENSEMBL Gene Tree for MED20 (if available)
    TreeFam Gene Tree for MED20 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/241 NCBI SNPs in MED20 are shown (see all 241    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs570919301,2
    C,--41872685(+) TGCACG/ATGCCT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1391511901,2
    --41872745(+) GGAAGC/TGGAGG 1 -- ds50010--------
    rs1424553671,2
    --41872767(+) CAAGAC/TTGTAC 1 -- ds50010--------
    rs792628341,2
    --41873104(+) TGTGCA/GTTTTA 1 -- ut310--------
    rs77595951,2
    C,F,H,--41873221(+) GTACTG/TAACTG 1 -- ut31 ese310Minor allele frequency- T:0.04NS EA NA WA 1206
    rs1486077761,2
    --41873531(+) AGCATA/GGTGCA 1 -- ut310--------
    rs1902778061,2
    --41873554(+) AAGTAC/TTCTAA 1 -- ut310--------
    rs1820466941,2
    --41873573(+) TCAGGA/GTGCAT 1 -- ut310--------
    rs1420766261,2
    --41873641(+) TAGTGC/TGACTA 1 -- ut310--------
    rs2011047951,2
    C--41873736(-) ATTTTG/TCAGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MED20 (41873092 - 41888877 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MED20: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MED20 for disorders           About GeneDecksing

    OMIM gene information: 612915    OMIM disorders: --

    2 diseases for MED20:    About MalaCards
    alpha thalassemia    thalassemia

    1 disease from the University of Copenhagen DISEASES database for MED20:
    Alpha thalassemia

    Export disorders for MED20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED20 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with MED20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S....Conaway R.C. (2004)
    2. The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex. (PubMed id 9933582)1, 2, 3 Xiao H.... Roeder R.G. (1999)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)1 Krebs A.R....Tora L. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9477 HGNC: 16840 AceView: USP49andMGC20741 Ensembl:ENSG00000124641 euGenes: HUgn9477
    ECgene: MED20 H-InvDB: MED20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED20 gene:
    Search GeneIP for patents involving MED20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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