Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED19 Gene

protein-coding   GIFtS: 52
GCID: GC11M057471

mediator complex subunit 19

(Previous names: mediator of RNA polymerase II transcription, subunit 19...)
 Explore 10 diseases affiliated with
MED19 via our new
 Human Malady Compendium 
Biological research products
for MED19
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 191 2 3     DT2P1G72
LCMR11 2 3     Mediator Of RNA Polymerase II Transcription Subunit 192
Lung Cancer Metastasis-Related Protein 12 3     Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog2
Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 296001   Entrez Gene: 2195412   Ensembl: ENSG000001566037   OMIM: 6123855   UniProtKB: A0JLT23   

Export aliases for MED19 gene to outside databases

Previous GC identifers: GC11M057228 GC11M053820


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED19:
MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate
transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)

UniProtKB/Swiss-Prot: MED19_HUMAN, A0JLT2
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED19 gene promoter:
         GR   AML1a   NRSF form 1   GR-beta   NRSF form 2   POU2F1   POU2F1a   c-Myb   GR-alpha   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED19 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

MED19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057471:  view genomic region     (about GC identifiers)

Start:
57,471,186 bp from pter      End:
57,479,693 bp from pter
Size:
8,508 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED19_HUMAN, A0JLT2 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 19  
Size: 244 amino acids; 26273 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAN16075.1; Type=Erroneous initiation;
Secondary accessions: Q8IV02 Q8IZD1
Alternative splicing: 2 isoforms:  A0JLT2-1   A0JLT2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MED19: NX_A0JLT2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A0JLT2

  • MED19 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_703151.1  
    ENSEMBL proteins: 
     ENSP00000337340   ENSP00000416227  
    Reactome Protein details: A0JLT2
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MED19
    OriGene Custom Protein Services for MED19 
    GenScript Custom Purified and Recombinant Proteins Services for MED19
    Novus Biologicals MED19 Protein
    Novus Biologicals MED19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED19

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016592mediator complex IEA--


    MED19 for ontologies           About GeneDecksing



    MED19 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED19 
    GenScript Custom Superior Antibodies Services for MED19
    Novus Biologicals MED19 Antibodies
    Search for Antibodies for MED19 at Abcam  
    Uscn Antibodies for MED19
    Search ThermoFisher Antibodies for MED19

    Assay Products for MED19: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED19
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MED19


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MED19 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019403 Mediator_Med19_met

    Graphical View of Domain Structure for InterPro Entry A0JLT2

    ProtoNet protein and cluster: A0JLT2

    UniProtKB/Swiss-Prot: MED19_HUMAN, A0JLT2
    Similarity: Belongs to the Mediator complex subunit 19 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MED19_HUMAN, A0JLT2
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: MED19
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED19
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MED19 (see all 23):
    hsa-miR-578 hsa-miR-378b hsa-miR-877* hsa-miR-1304 hsa-miR-661 hsa-miR-558 hsa-miR-323-5p hsa-miR-378
    SwitchGear 3'UTR luciferase reporter plasmidMED19 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED19 (see all 7)
    OriGene shRNA RFP: MED19
    OriGene siRNA: MED19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED19

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED19 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED19
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED19 (NM_153450)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED19 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED19
    Search LifeMap BioReagents cell lines for MED19

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED19

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding ----


    MED19 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for MED19:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation1.00
    2Axon guidance
    Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for MED19
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation



    MED19 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/169 Interacting proteins for MED19 (A0JLT22, 3 ENSP000003373404) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHRS7BQ6IAN02, 3, ENSP000003788874MINT-64898 I2D: score=4 STRING: ENSP00000378887
    RADILQ96JH82, 3, ENSP000003824924MINT-64897 I2D: score=4 STRING: ENSP00000382492
    DCKP277072, 3MINT-64896 I2D: score=5 
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    NFKBIAP259632, 3, ENSP000002167974MINT-64895 I2D: score=5 STRING: ENSP00000216797
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED19
    Search CenterWatch for drugs/clinical trials and news about MED19 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED19 gene: 
    NM_153450.1  

    Unigene Cluster for MED19:

    Mediator complex subunit 19
    Hs.43619  [show with all ESTs]
    Unigene Representative Sequence: BC037223
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337672(uc001nlb.3) ENST00000431606(uc001nla.1) ENST00000528205
    ENST00000534677

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MED19
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED19
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MED19 (see all 23):
    hsa-miR-578 hsa-miR-378b hsa-miR-877* hsa-miR-1304 hsa-miR-661 hsa-miR-558 hsa-miR-323-5p hsa-miR-378
    SwitchGear 3'UTR luciferase reporter plasmidMED19 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED19 (see all 7)
    OriGene shRNA RFP: MED19
    OriGene siRNA: MED19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED19
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED19 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED19
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED19 (NM_153450)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED19 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED19
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED19
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED19

    Additional cDNA sequence: 

    AY148462.1 BC009723.1 BC037223.1 HE646678.2 U92995.1 

    6 DOTS entries:

    DT.446544  DT.120689275  DT.100027052  DT.100685630  DT.120689272  DT.92423153 

    24/146 AceView cDNA sequences (see all 146):

    AA886720 BF438662 AA743555 AI871035 AA863018 BM354014 AI280433 AA902201 
    BM929707 CD674195 CA446511 NM_153450 BM725608 BC037223 AA603310 BC009723 
    BM910772 BE676048 BU166665 N53306 CD673007 BU070311 BM720278 BM763986 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED19    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                                      -         
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for MED19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACATCTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MED19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED19

    SOURCE GeneReport for Unigene cluster: Hs.43619
        SABiosciences Custom PCR Arrays for MED19
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED19
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED19
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED19
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED19 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med191 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 85.57(n)1
    92.27(a)1
      2 (49.45 cM)5
    3813791  NM_025885.31  NP_080161.11 
     846784025 
    chicken
    (Gallus gallus)
    Aves MED191 mediator complex subunit 19 77.72(n)
    83.7(a)
      428854  XM_426411.2  XP_426411.2 
    lizard
    (Anolis carolinensis)
    Reptilia MED196
    --
    65(a)
    1 ↔ 1
    1(91520553-91527039)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985382 hypothetical protein LOC398538 77.99(n)    BC042241.1 
    zebrafish
    (Danio rerio)
    Actinopterygii med19a1 mediator complex subunit 19a 63.7(n)
    70(a)
      767651  NM_001076591.1  NP_001070059.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED191 Mediator complex subunit 19 52.47(n)
    46.3(a)
      39987  NM_140759.2  NP_649016.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-196
    Mediator of RNA polymerase II transcription subuni...
    23(a)
    1 ↔ 1
    III(2598052-2603212)


    ENSEMBL Gene Tree for MED19 (if available)
    TreeFam Gene Tree for MED19 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 NCBI SNPs in MED19 are shown (see all 103    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878293491,2
    --57470777(+) GAAGCG/TTTACC 1 -- int10--------
    rs5444461,2
    C,F,A,H,--57470844(+) TCTTGT/CTGAAA 1 -- int120Minor allele frequency- C:0.40NS EA NA CSA WA 2345
    rs1920724921,2
    --57470852(+) AAACAC/TATGGG 1 -- int10--------
    rs1472881111,2
    --57470894(+) TCTTTC/TGACAC 1 -- int10--------
    rs108966381,2
    C,H--57470941(+) GATCAG/ACTCTT 1 -- int14Minor allele frequency- A:0.00NS EA 406
    rs1839724811,2
    --57470955(+) ATGGAA/GCCTGA 1 -- int10--------
    rs1877871731,2
    --57470972(+) CGAGGC/TGCTTG 1 -- int10--------
    rs1922273491,2
    --57470999(+) GCAGAA/GTGTTA 1 -- int10--------
    rs1843843631,2
    --57471244(+) TCAGAA/CAAATT 1 -- ut310--------
    rs9478871,2
    C,H--57471249(+) CAAATT/GGCACA 1 -- ut315Minor allele frequency- G:0.00MN NS EA 584

    HapMap Linkage Disequilibrium report for MED19 (57471186 - 57479693 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MED19
         1 CNV: 4744

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED19
    DNA2.0 Custom Variant and Variant Library Synthesis for MED19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MED19 for disorders           About GeneDecksing

    OMIM gene information: 612385    OMIM disorders: --

    10 diseases for MED19:    About MalaCards
    lung cancer    lipoma    breast lipoma    hepatocellular carcinoma
    osteosarcoma    prostate cancer    breast cancer    prostatitis
    carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MED19:
    Breast lipoma

    Export disorders for MED19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED19 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with MED19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    2. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (2003)
    3. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)1, 3 Reddy P.H....Tagle D.A. (1997)
    4. Med19 promotes gastric cancer progression and cellular growth. (PubMed id 22565189)1 Ding X.F....Fang X.D. (2012)
    5. Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cells. (PubMed id 21732059)1 Ji-Fu E....Fu C.G. (2012)
    6. Suppression of MED19 expression by shRNA induces inhi bition of cell proliferation and tumorigenesis in human prostate cancer cells. (PubMed id 21871180)1 Cui X....Yu H. (2011)
    7. Lentivirus-mediated inhibition of Med19 suppresses gr owth of breast cancer cells in vitro. (PubMed id 20890603)1 Li L.H....Gao Q. (2011)
    8. The role of Med19 in the proliferation and tumorigene sis of human hepatocellular carcinoma cells. (PubMed id 21372827)1 Zou S.W....Zheng Q. (2011)
    9. Overexpression of LCMR1 is significantly associated w ith clinical stage in human NSCLC. (PubMed id 21306606)1 Chen L....Li Y. (2011)
    10. MED19 promotes proliferation and tumorigenesis of lun g cancer. (PubMed id 21519921)1 Sun M....Zhang X.Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219541 HGNC: 29600 AceView: LCMR1 Ensembl:ENSG00000156603 euGenes: HUgn219541
    ECgene: MED19 H-InvDB: MED19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MED19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED19 gene:
    Search GeneIP for patents involving MED19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MED19  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED19   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED19  
     OriGene Protein Over-expression Lysate for MED19   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MED19   OriGene 3'-UTR Clone for MED19  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED19   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED19  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MED19   OriGene Custom Protein Services for MED19  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MED19
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED19
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED19
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED19
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED19
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED19
     GenScript Custom Purified and Recombinant Proteins Services for MED19 GenScript cDNA clones with any tag delivered in your preferred vector for MED19
     GenScript Custom Assay Services for MED19 GenScript Custom Superior Antibodies Services for MED19
     GenScript Custom overexpressing Cell Line Services for MED19 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MED19 promoter
     Search Chromatin IP Primers for MED19
     RT2 qPCR Primer Assay in human, mouse, rat MED19
     Search GNC Networks for MED19
     SABiosciences Custom PCR Arrays for MED19
     Search Tocris compounds for MED19
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MED19 antibodies
     MED19 proteins
     MED19 lysates
     Search for Antibodies for MED19 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MED19
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MED19 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MED19
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED19
     SwitchGear 3'UTR luciferase reporter plasmids for MED19
     SwitchGear Promoter luciferase reporter plasmids for MED19
     Search ThermoFisher Antibodies for MED19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED19
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MED19 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4