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Aliases for MED19 Gene

Aliases for MED19 Gene

  • Mediator Complex Subunit 19 2 3 4
  • Lung Cancer Metastasis-Related Protein 1 3 4
  • LCMR1 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 19 3
  • DT2P1G7 3

External Ids for MED19 Gene

Previous GeneCards Identifiers for MED19 Gene

  • GC11M057228
  • GC11M057471
  • GC11M053820

Summaries for MED19 Gene

Entrez Gene Summary for MED19 Gene

  • MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED19 Gene

MED19 (Mediator Complex Subunit 19) is a Protein Coding gene. Diseases associated with MED19 include breast lipoma and med23. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED19 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED19 Gene

Genomics for MED19 Gene

Regulatory Elements for MED19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED19 Gene

Start:
57,703,710 bp from pter
End:
57,712,324 bp from pter
Size:
8,615 bases
Orientation:
Minus strand

Genomic View for MED19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED19 Gene

Proteins for MED19 Gene

  • Protein details for MED19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0JLT2-MED19_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 19
    Protein Accession:
    A0JLT2
    Secondary Accessions:
    • Q8IV02
    • Q8IZD1

    Protein attributes for MED19 Gene

    Size:
    244 amino acids
    Molecular mass:
    26273 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAN16075.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED19 Gene

Proteomics data for MED19 Gene at MOPED

Post-translational modifications for MED19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED19 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED19 Gene

Domains for MED19 Gene

Protein Domains for MED19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0JLT2

UniProtKB/Swiss-Prot:

MED19_HUMAN :
  • A0JLT2
Family:
  • Belongs to the Mediator complex subunit 19 family.
genes like me logo Genes that share domains with MED19: view

No data available for Gene Families for MED19 Gene

Function for MED19 Gene

Molecular function for MED19 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO) - Molecular Function for MED19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 14576168
genes like me logo Genes that share ontologies with MED19: view
genes like me logo Genes that share phenotypes with MED19: view

Animal Model Products

CRISPR Products

miRNA for MED19 Gene

miRTarBase miRNAs that target MED19

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED19 Gene

Localization for MED19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED19 Gene COMPARTMENTS Subcellular localization image for MED19 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MED19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with MED19: view

Pathways for MED19 Gene

genes like me logo Genes that share pathways with MED19: view

Gene Ontology (GO) - Biological Process for MED19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MED19: view

Transcripts for MED19 Gene

Unigene Clusters for MED19 Gene

Mediator complex subunit 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:
SP3:

Relevant External Links for MED19 Gene

GeneLoc Exon Structure for
MED19
ECgene alternative splicing isoforms for
MED19

Expression for MED19 Gene

mRNA expression in normal human tissues for MED19 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED19 Gene

SOURCE GeneReport for Unigene cluster for MED19 Gene Hs.43619

genes like me logo Genes that share expressions with MED19: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED19 Gene

Orthologs for MED19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED19 35
  • 98.45 (n)
  • 98.45 (a)
MED19 36
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED19 35
  • 86.77 (n)
  • 93.81 (a)
MED19 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED19 35
  • 89.35 (n)
  • 94.33 (a)
MED19 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med19 35
  • 85.57 (n)
  • 92.27 (a)
Med19 16
Med19 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MED19 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med19 35
  • 85.4 (n)
  • 92.78 (a)
chicken
(Gallus gallus)
Aves MED19 35
  • 74.23 (n)
  • 78.92 (a)
MED19 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED19 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398538 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med19 35
  • 70.43 (n)
  • 75.94 (a)
Str.7300 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5931 35
zebrafish
(Danio rerio)
Actinopterygii med19a 36
  • 50 (a)
OneToMany
med19b 35
  • 70.05 (n)
  • 77.54 (a)
med19b 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MED19 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-19 36
  • 23 (a)
OneToOne
Species with no ortholog for MED19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED19 Gene

ENSEMBL:
Gene Tree for MED19 (if available)
TreeFam:
Gene Tree for MED19 (if available)

Paralogs for MED19 Gene

Selected SIMAP similar genes for MED19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MED19: view

No data available for Paralogs for MED19 Gene

Variants for MED19 Gene

Sequence variations from dbSNP and Humsavar for MED19 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs491719 -- 57,708,048(-) AAGAC(C/T)AGCCT intron-variant
rs522773 -- 57,704,797(+) CATCA(A/G)ACGAC reference, synonymous-codon
rs544446 -- 57,703,372(+) TCTTG(C/T)TGAAA downstream-variant-500B
rs624000 -- 57,704,705(+) GAATA(A/G)AACTG intron-variant
rs671954 -- 57,704,583(-) CTGAA(A/G)AAAAA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED19 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489

Relevant External Links for MED19 Gene

HapMap Linkage Disequilibrium report
MED19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED19 Gene

Disorders for MED19 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MED19 Gene including...

Search for MED19 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MED19 Gene

genes like me logo Genes that share disorders with MED19: view

No data available for UniProtKB/Swiss-Prot for MED19 Gene

Publications for MED19 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4
  2. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy P.H. … Tagle D.A. (Genomics 1997) 2 3
  3. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 3 4
  4. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. (PMID: 14576168) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 3
  5. A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. (PMID: 14638676) Tomomori-Sato C. … Conaway J.W. (J. Biol. Chem. 2004) 3

Products for MED19 Gene

Sources for MED19 Gene

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