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Aliases for MED19 Gene

Aliases for MED19 Gene

  • Mediator Complex Subunit 19 2 3 4 5
  • Lung Cancer Metastasis-Related Protein 1 3 4
  • LCMR1 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 19 3
  • Putative Mediator Subunit MED19AS Protein 3
  • DT2P1G7 3
  • MED19AS 3

External Ids for MED19 Gene

Previous GeneCards Identifiers for MED19 Gene

  • GC11M057228
  • GC11M057471
  • GC11M053820

Summaries for MED19 Gene

Entrez Gene Summary for MED19 Gene

  • The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for MED19 Gene

MED19 (Mediator Complex Subunit 19) is a Protein Coding gene. Diseases associated with MED19 include Breast Lipoma and Congenital Disorder Of Deglycosylation. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED19 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Additional gene information for MED19 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED19 Gene

Genomics for MED19 Gene

Regulatory Elements for MED19 Gene

Enhancers for MED19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H057774 2 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -69.5 -69504 15 PKNOX1 FOXA2 MLX SIN3A FEZF1 FOS SP5 NFYC JUNB REST YPEL4 TIMM10 MED19 SELENOH CTNND1 BTBD18 ENSG00000254732 CLP1 ENSG00000254602 SMTNL1
GH11H057790 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -80.1 -80145 3 HDGF PKNOX1 ATF1 TBL1XR1 SIN3A BATF ZNF143 ATF7 ETV6 RUNX3 MED19 SLC43A3 SMTNL1 UBE2L6 ZDHHC5 CLP1 PIR53177 GC11P057856
GH11H057797 1.6 Ensembl ENCODE dbSUPER 14.2 -88.2 -88199 5 HDGF PKNOX1 FOXA2 ATF1 MLX ARNT ARID4B SIN3A ZNF2 YY1 MED19 YPEL4 BTBD18 CTNND1 SELENOH ENSG00000254732 TIMM10 PIR53177 GC11P057856
GH11H057666 1.4 ENCODE dbSUPER 13.7 +44.0 43978 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 CBX5 ZNF143 SSRP1 ENSG00000269570 ZFP91 MED19 YPEL4 SELENOH ENSG00000254732 CTNND1 BTBD18 RN7SKP259
GH11H057644 1.6 Ensembl ENCODE dbSUPER 11.4 +65.0 64992 6 HDGF ATF1 ARNT ARID4B YBX1 TCF12 ZNF121 ZNF766 GLIS2 GATA2 SSRP1 ENSG00000269570 TIMM10 MED19 CLP1 MIR130A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED19 on UCSC Golden Path with GeneCards custom track

Promoters for MED19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039916 -62 2201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for MED19 Gene

Chromosome:
11
Start:
57,703,709 bp from pter
End:
57,712,438 bp from pter
Size:
8,730 bases
Orientation:
Minus strand

Genomic View for MED19 Gene

Genes around MED19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED19 Gene

Proteins for MED19 Gene

  • Protein details for MED19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0JLT2-MED19_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 19
    Protein Accession:
    A0JLT2
    Secondary Accessions:
    • Q8IV02
    • Q8IZD1

    Protein attributes for MED19 Gene

    Size:
    244 amino acids
    Molecular mass:
    26273 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAN16075.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED19 Gene

Post-translational modifications for MED19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED19 Gene

Domains & Families for MED19 Gene

Gene Families for MED19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0JLT2

UniProtKB/Swiss-Prot:

MED19_HUMAN :
  • Belongs to the Mediator complex subunit 19 family.
Family:
  • Belongs to the Mediator complex subunit 19 family.
genes like me logo Genes that share domains with MED19: view

Function for MED19 Gene

Molecular function for MED19 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED19 Gene

Gene Ontology (GO) - Molecular Function for MED19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 14576168
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with MED19: view
genes like me logo Genes that share phenotypes with MED19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MED19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED19 Gene

Localization for MED19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED19 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MED19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0016592 mediator complex IBA,IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with MED19: view

Pathways & Interactions for MED19 Gene

genes like me logo Genes that share pathways with MED19: view

Gene Ontology (GO) - Biological Process for MED19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with MED19: view

No data available for SIGNOR curated interactions for MED19 Gene

Drugs & Compounds for MED19 Gene

No Compound Related Data Available

Transcripts for MED19 Gene

Unigene Clusters for MED19 Gene

Mediator complex subunit 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MED19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MED19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:
SP3:

Relevant External Links for MED19 Gene

GeneLoc Exon Structure for
MED19
ECgene alternative splicing isoforms for
MED19

Expression for MED19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED19 Gene

Protein differential expression in normal tissues from HIPED for MED19 Gene

This gene is overexpressed in CD8 Tcells (40.6) and Placenta (28.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED19 Gene



Protein tissue co-expression partners for MED19 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED19 Gene:

MED19

SOURCE GeneReport for Unigene cluster for MED19 Gene:

Hs.43619

Evidence on tissue expression from TISSUES for MED19 Gene

  • Nervous system(4.4)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with MED19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED19 Gene

Orthologs for MED19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED19 33 34
  • 98.45 (n)
dog
(Canis familiaris)
Mammalia MED19 33 34
  • 89.35 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MED19 33 34
  • 86.77 (n)
mouse
(Mus musculus)
Mammalia Med19 33 16 34
  • 85.57 (n)
rat
(Rattus norvegicus)
Mammalia Med19 33
  • 85.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED19 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED19 33 34
  • 74.23 (n)
lizard
(Anolis carolinensis)
Reptilia MED19 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med19 33
  • 70.43 (n)
Str.7300 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398538 33
zebrafish
(Danio rerio)
Actinopterygii med19b 33 34
  • 70.05 (n)
med19a 34
  • 50 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5931 33
fruit fly
(Drosophila melanogaster)
Insecta MED19 34
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-19 34
  • 23 (a)
OneToOne
Species where no ortholog for MED19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED19 Gene

ENSEMBL:
Gene Tree for MED19 (if available)
TreeFam:
Gene Tree for MED19 (if available)

Paralogs for MED19 Gene

(1) SIMAP similar genes for MED19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MED19: view

No data available for Paralogs for MED19 Gene

Variants for MED19 Gene

Sequence variations from dbSNP and Humsavar for MED19 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000327817 -- 57,708,535(+) TCATT(C/G)TGGAT intron-variant
rs1000407539 -- 57,703,919(+) AGCTG(C/G)CCTCT utr-variant-3-prime
rs1000435541 -- 57,708,159(+) GTTTT(A/G)AAATT intron-variant
rs1000655769 -- 57,710,668(+) TCTCT(A/G)GCCAC intron-variant, upstream-variant-2KB
rs1000662931 -- 57,710,091(+) GCACA(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED19 Gene

Variant ID Type Subtype PubMed ID
esv3579728 CNV loss 25503493
nsv508633 CNV deletion 20534489
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Variation tolerance for MED19 Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED19 Gene

Disorders for MED19 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MED19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast lipoma
  • lipoma of breast
congenital disorder of deglycosylation
  • ngly1-deficiency
- elite association - COSMIC cancer census association via MalaCards
Search MED19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MED19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED19
genes like me logo Genes that share disorders with MED19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED19 Gene

Publications for MED19 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 60
  2. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S … Conaway JW (The Journal of biological chemistry 2003) 3 4 60
  3. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy PH … Tagle DA (Genomics 1997) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Med19 promotes breast cancer cell proliferation by regulating CBFA2T3/HEB expression. (PMID: 27572702) Zhang X … Li L (Breast cancer (Tokyo, Japan) 2017) 3 60

Products for MED19 Gene

Sources for MED19 Gene

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