Aliases for MED19 Gene
- Mediator Complex Subunit 19 2 3 4 5
- Lung Cancer Metastasis-Related Protein 1 3 4
- LCMR1 3 4
- Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog (S. Cerevisiae) 2
- Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog 3
- Putative Mediator Subunit MED19AS Protein 3
- DT2P1G7 3
- MED19AS 3
External Ids for MED19 Gene
Previous GeneCards Identifiers for MED19 Gene
The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for MED19 Gene
MED19 (Mediator Complex Subunit 19) is a Protein Coding gene. Diseases associated with MED19 include breast lipoma and lung cancer. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include RNA polymerase II transcription cofactor activity.
UniProtKB/Swiss-Prot for MED19 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.