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Aliases for MED19 Gene

Aliases for MED19 Gene

  • Mediator Complex Subunit 19 2 3 4 5
  • Lung Cancer Metastasis-Related Protein 1 3 4
  • LCMR1 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog 3
  • Putative Mediator Subunit MED19AS Protein 3
  • DT2P1G7 3
  • MED19AS 3

External Ids for MED19 Gene

Previous GeneCards Identifiers for MED19 Gene

  • GC11M057228
  • GC11M057471
  • GC11M053820

Summaries for MED19 Gene

Entrez Gene Summary for MED19 Gene

  • The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for MED19 Gene

MED19 (Mediator Complex Subunit 19) is a Protein Coding gene. Diseases associated with MED19 include breast lipoma and lung cancer. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED19 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED19 Gene

Genomics for MED19 Gene

Regulatory Elements for MED19 Gene

Promoters for MED19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED19 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED19 Gene

Chromosome:
11
Start:
57,703,709 bp from pter
End:
57,712,438 bp from pter
Size:
8,730 bases
Orientation:
Minus strand

Genomic View for MED19 Gene

Genes around MED19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED19 Gene

Proteins for MED19 Gene

  • Protein details for MED19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0JLT2-MED19_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 19
    Protein Accession:
    A0JLT2
    Secondary Accessions:
    • Q8IV02
    • Q8IZD1

    Protein attributes for MED19 Gene

    Size:
    244 amino acids
    Molecular mass:
    26273 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAN16075.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED19 Gene

Proteomics data for MED19 Gene at MOPED

Post-translational modifications for MED19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MED19 Gene

Domains & Families for MED19 Gene

Gene Families for MED19 Gene

Protein Domains for MED19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0JLT2

UniProtKB/Swiss-Prot:

MED19_HUMAN :
  • Belongs to the Mediator complex subunit 19 family.
Family:
  • Belongs to the Mediator complex subunit 19 family.
genes like me logo Genes that share domains with MED19: view

Function for MED19 Gene

Molecular function for MED19 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
genes like me logo Genes that share phenotypes with MED19: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED19 Gene

Localization for MED19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED19 Gene COMPARTMENTS Subcellular localization image for MED19 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for MED19 Gene

Pathways & Interactions for MED19 Gene

genes like me logo Genes that share pathways with MED19: view

Gene Ontology (GO) - Biological Process for MED19 Gene

None

No data available for SIGNOR curated interactions for MED19 Gene

Drugs & Compounds for MED19 Gene

No Compound Related Data Available

Transcripts for MED19 Gene

Unigene Clusters for MED19 Gene

Mediator complex subunit 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:
SP3:

Relevant External Links for MED19 Gene

GeneLoc Exon Structure for
MED19
ECgene alternative splicing isoforms for
MED19

Expression for MED19 Gene

mRNA expression in normal human tissues for MED19 Gene

Protein differential expression in normal tissues from HIPED for MED19 Gene

This gene is overexpressed in CD8 Tcells (40.6) and Placenta (28.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED19 Gene



SOURCE GeneReport for Unigene cluster for MED19 Gene Hs.43619

genes like me logo Genes that share expression patterns with MED19: view

Protein tissue co-expression partners for MED19 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED19 Gene

Orthologs for MED19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED19 35
  • 86.77 (n)
  • 93.81 (a)
MED19 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED19 35
  • 89.35 (n)
  • 94.33 (a)
MED19 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med19 35
  • 85.57 (n)
  • 92.27 (a)
Med19 16
Med19 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED19 35
  • 98.45 (n)
  • 98.45 (a)
MED19 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med19 35
  • 85.4 (n)
  • 92.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MED19 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED19 35
  • 74.23 (n)
  • 78.92 (a)
MED19 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED19 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med19 35
  • 70.43 (n)
  • 75.94 (a)
Str.7300 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398538 35
zebrafish
(Danio rerio)
Actinopterygii med19b 35
  • 70.05 (n)
  • 77.54 (a)
med19a 36
  • 50 (a)
OneToMany
med19b 36
  • 49 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5931 35
fruit fly
(Drosophila melanogaster)
Insecta MED19 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-19 36
  • 23 (a)
OneToOne
Species with no ortholog for MED19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED19 Gene

ENSEMBL:
Gene Tree for MED19 (if available)
TreeFam:
Gene Tree for MED19 (if available)

Paralogs for MED19 Gene

(1) SIMAP similar genes for MED19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MED19: view

No data available for Paralogs for MED19 Gene

Variants for MED19 Gene

Sequence variations from dbSNP and Humsavar for MED19 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs491719 -- 57,708,048(-) AAGAC(C/T)AGCCT intron-variant
rs522773 -- 57,704,797(+) CATCA(A/G)ACGAC reference, synonymous-codon
rs544446 -- 57,703,372(+) TCTTG(C/T)TGAAA downstream-variant-500B
rs624000 -- 57,704,705(+) GAATA(A/G)AACTG intron-variant
rs671954 -- 57,704,583(-) CTGAA(A/G)AAAAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MED19 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489

Variation tolerance for MED19 Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED19 Gene

HapMap Linkage Disequilibrium report
MED19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED19 Gene

Disorders for MED19 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MED19 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast lipoma
  • lipoma of breast
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search MED19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MED19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED19
genes like me logo Genes that share disorders with MED19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED19 Gene

Publications for MED19 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4 67
  2. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy P.H. … Tagle D.A. (Genomics 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Mediator of RNA polymerase II transcription subunit 19 promotes osteosarcoma growth and metastasis and associates with prognosis. (PMID: 24565852) Yu W. … Shen Z. (Eur. J. Cancer 2014) 3

Products for MED19 Gene

Sources for MED19 Gene

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