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MED19 Gene

protein-coding   GIFtS: 53
GCID: GC11M057471

Mediator Complex Subunit 19

(Previous names: mediator of RNA polymerase II transcription, subunit 19...)
  See MED19-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 191 2 3     DT2P1G72
Lung Cancer Metastasis-Related Protein 12 3     Mediator Of RNA Polymerase II Transcription Subunit 192
LCMR12 3     Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog2
Mediator Of RNA Polymerase II Transcription, Subunit 19 Homolog (S.
Cerevisiae)1
     

External Ids:    HGNC: 296001   Entrez Gene: 2195412   Ensembl: ENSG000001566037   OMIM: 6123855   UniProtKB: A0JLT23   

Export aliases for MED19 gene to outside databases

Previous GC identifers: GC11M057228 GC11M053820


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED19 Gene:
MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate
transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)

GeneCards Summary for MED19 Gene:
MED19 (mediator complex subunit 19) is a protein-coding gene. Diseases associated with MED19 include breast lipoma, and lung cancer. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot: MED19_HUMAN, A0JLT2
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED19 gene promoter:
         GR   AML1a   NRSF form 1   GR-beta   NRSF form 2   POU2F1   POU2F1a   c-Myb   GR-alpha   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED19 promoter sequence
   Search Chromatin IP Primers for MED19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

MED19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057471:  view genomic region     (about GC identifiers)

Start:
57,471,186 bp from pter      End:
57,479,693 bp from pter
Size:
8,508 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MED19_HUMAN, A0JLT2 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 19  
Size: 244 amino acids; 26273 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Sequence caution: Sequence=AAN16075.1; Type=Erroneous initiation;
Secondary accessions: Q8IV02 Q8IZD1
Alternative splicing: 2 isoforms:  A0JLT2-1   A0JLT2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MED19: NX_A0JLT2

Explore proteomics data for MED19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MED19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_703151.1  
    ENSEMBL proteins: 
     ENSP00000337340   ENSP00000416227  
    Reactome Protein details: A0JLT2

    MED19 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED19
    OriGene Protein Over-expression Lysate for MED19
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MED19
    GenScript Custom Purified and Recombinant Proteins Services for MED19
    Novus Biologicals MED19 Protein
    Novus Biologicals MED19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED19

     
    Search eBioscience for Proteins for MED19 

    MED19 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED19
    Novus Biologicals MED19 Antibodies
    Abcam antibodies for MED19
    Cloud-Clone Corp. Antibodies for MED19
    Search ThermoFisher Antibodies for MED19
    LSBio Antibodies in human, mouse, rat for MED19

    MED19 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED19
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED19
    Cloud-Clone Corp. CLIAs for MED19
    Search eBioscience for ELISAs for MED19 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019403 Mediator_Med19_met

    Graphical View of Domain Structure for InterPro Entry A0JLT2

    ProtoNet protein and cluster: A0JLT2

    UniProtKB/Swiss-Prot: MED19_HUMAN, A0JLT2
    Similarity: Belongs to the Mediator complex subunit 19 family


    Find genes that share domains with MED19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED19_HUMAN, A0JLT2
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MED19           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MED19:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED19
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED19
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED19

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED19:
    hsa-mir-32-5p (MIRT028266), hsa-mir-1229-3p (MIRT036344)

    Block miRNA regulation of human, mouse, rat MED19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED19 (see all 23):
    hsa-miR-578 hsa-miR-378b hsa-miR-877* hsa-miR-1304 hsa-miR-661 hsa-miR-558 hsa-miR-323-5p hsa-miR-378
    SwitchGear 3'UTR luciferase reporter plasmidMED19 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED19
    Predesigned siRNA for gene silencing in human, mouse, rat MED19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED19

    Clone
    Products:
         
    OriGene clones in human, mouse for MED19 (see all 6)
    OriGene ORF clones in mouse, rat for MED19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED19 (NM_153450)
    Sino Biological Human cDNA Clone for MED19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED19

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED19
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED19 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED19_HUMAN, A0JLT2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016592mediator complex IEA--

    Find genes that share ontologies with MED19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED19 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3L1CAM interactions
    Developmental Biology0.63


    Find genes that share SuperPaths with MED19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for MED19
        Transcriptional regulation of white adipocyte differentiation
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED19
    Interactions:

        Search GeneGlobe Interaction Network for MED19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED19 (A0JLT22, 3 ENSP000003373404) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHRS7BQ6IAN02, 3, ENSP000003788874MINT-64898 I2D: score=4 STRING: ENSP00000378887
    RADILQ96JH82, 3, ENSP000003824924MINT-64897 I2D: score=4 STRING: ENSP00000382492
    DCKP277072, 3MINT-64896 I2D: score=5 
    DDX39BQ138383I2D: score=1 
    ENSG00000215425Q138383I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with MED19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED19



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MED19 gene: 
    NM_153450.1  

    Unigene Cluster for MED19:

    Mediator complex subunit 19
    Hs.43619  [show with all ESTs]
    Unigene Representative Sequence: BC037223
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337672(uc001nlb.3) ENST00000431606(uc001nla.1) ENST00000528205
    ENST00000534677
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED19 (see all 23):
    hsa-miR-578 hsa-miR-378b hsa-miR-877* hsa-miR-1304 hsa-miR-661 hsa-miR-558 hsa-miR-323-5p hsa-miR-378
    SwitchGear 3'UTR luciferase reporter plasmidMED19 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED19
    Predesigned siRNA for gene silencing in human, mouse, rat MED19
    Clone
    Products:
         
    OriGene clones in human, mouse for MED19 (see all 6)
    OriGene ORF clones in mouse, rat for MED19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED19 (NM_153450)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED19
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED19
    OriGene qSTAR qPCR primer pairs in human, mouse for MED19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED19
      QuantiTect SYBR Green Assays in human, mouse, rat MED19
      QuantiFast Probe-based Assays in human, mouse, rat MED19

    Additional mRNA sequence: 

    AY148462.1 BC009723.1 BC037223.1 HE646678.2 U92995.1 

    6 DOTS entries:

    DT.446544  DT.120689275  DT.100027052  DT.100685630  DT.120689272  DT.92423153 

    Selected AceView cDNA sequences (see all 146):

    BM763986 CA446511 BF109144 CB143258 AI673010 AA830614 BE781103 BE676048 
    AI393522 AI871035 AA743555 CA418568 AA886720 BC009723 AW511318 BM910772 
    AA039918 BU632823 N95590 BM929707 AA902201 BM142160 BC037223 AI280433 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MED19    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                                      -         
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for MED19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACATCTCTT
    MED19 Expression
    About this image

    MED19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43619
        Custom PCR Arrays for MED19
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED19
    OriGene qSTAR qPCR primer pairs in human, mouse for MED19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED19
    QuantiTect SYBR Green Assays in human, mouse, rat MED19
    QuantiFast Probe-based Assays in human, mouse, rat MED19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED19 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med191 , 5 mediator of RNA polymerase II transcription, subunit more5
    mediator complex subunit 191
    85.57(n)1
    92.27(a)1
      2 (49.45 cM)5
    3813791  NM_025885.31  NP_080161.11 
     846784025 
    chicken
    (Gallus gallus)
    Aves MED191 mediator complex subunit 19 74.23(n)
    78.92(a)
      428854  XM_426411.3  XP_426411.2 
    lizard
    (Anolis carolinensis)
    Reptilia MED196
    mediator complex subunit 19
    65(a)
    1 ↔ 1
    1(91520550-91528927)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985382 hypothetical protein LOC398538 77.99(n)    BC042241.1 
    zebrafish
    (Danio rerio)
    Actinopterygii med19b1 mediator complex subunit 19b 70.05(n)
    77.54(a)
      445021  NM_001003416.2  NP_001003416.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED196
    Mediator complex subunit 19
    22(a)
    1 ↔ 1
    3L(17836915-17839601)
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-196
    Protein MDT-19 (mdt-19) mRNA, complete cds
    23(a)
    1 ↔ 1
    III(2598061-2603221) WBGene00007019


    ENSEMBL Gene Tree for MED19 (if available)
    TreeFam Gene Tree for MED19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MED19 gene
    1 SIMAP similar gene for MED19 using alignment to 2 protein entries:     MED19_HUMAN (see all proteins):
    MED19AS

    Find genes that share paralogs with MED19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED19 (see all 136)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878293491,2
    --57470777(+) GAAGCG/TTTACC 1 -- int10--------
    rs5444461,2
    C,F,A,H--57470844(+) TCTTGT/CTGAAA 1 -- int120Minor allele frequency- C:0.40NS EA NA CSA WA 2345
    rs1920724921,2
    --57470852(+) AAACAC/TATGGG 1 -- int10--------
    rs1472881111,2
    --57470894(+) TCTTTC/TGACAC 1 -- int10--------
    rs108966381,2
    C,H--57470941(+) GATCAG/ACTCTT 1 -- int14Minor allele frequency- A:0.00NS EA 406
    rs1839724811,2
    C--57470955(+) ATGGAA/GCCTGA 1 -- int10--------
    rs1877871731,2
    --57470972(+) CGAGGC/TGCTTG 1 -- int10--------
    rs1922273491,2
    C--57470999(+) GCAGAA/GTGTTA 1 -- int10--------
    rs1843843631,2
    --57471244(+) TCAGAA/CAAATT 1 -- ut310--------
    rs9478871,2
    C,H--57471249(+) CAAATT/GGCACA 1 -- ut315Minor allele frequency- G:0.00MN NS EA 584

    HapMap Linkage Disequilibrium report for MED19 (57471186 - 57479693 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MED19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832164CNV Loss17160897
    nsv508633CNV Loss20534489
    nsv832163CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED19
    DNA2.0 Custom Variant and Variant Library Synthesis for MED19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612385    OMIM disorders: --

    2 diseases for MED19:    
    About MalaCards
    breast lipoma    lung cancer

    1 disease from the University of Copenhagen DISEASES database for MED19:
    Breast lipoma

    Find genes that share disorders with MED19           About GenesLikeMe


    Export disorders for MED19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED19 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MED19)
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    1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    2. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (J. Biol. Chem. 2003)
    3. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)1, 3 Reddy P.H.... Tagle D.A. (Genomics 1997)
    4. Disruption of mediator complex subunit 19 (Med19) inhibits cell growth and migration in tongue cancer. (PubMed id 23705783)1 Zhu L.J....Liao G.Q. (World J Surg Oncol 2013)
    5. A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)1 Tsai K.L....Asturias F.J. (amp 2013)
    6. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (amp 2013)
    7. Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2. (PubMed id 23276457)1 Wen H....Jiang H.W. (Ann Diagn Pathol 2013)
    8. Suppression of lung cancer metastasis-related proteinA 1 promotes apoptosis in lung cancer cells. (PubMed id 23076562)1 Xu Y....Chen L. (Int. J. Mol. Med. 2012)
    9. Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cells. (PubMed id 21732059)1 Ji-Fu E....Fu C.G. (Mol. Biol. Rep. 2012)
    10. Expression of Med19 in bladder cancer tissues and its role on bladder cancer cell growth. (PubMed id 21478038)1 Zhang H....Ding Q. (Urol. Oncol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219541 HGNC: 29600 AceView: LCMR1 Ensembl:ENSG00000156603 euGenes: HUgn219541
    ECgene: MED19 H-InvDB: MED19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MED19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MED19 gene:
    Search GeneIP for patents involving MED19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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