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MED18 Gene

protein-coding   GIFtS: 51
GCID: GC01P028666

Mediator Complex Subunit 18

(Previous names: mediator of RNA polymerase II transcription, subunit 18...)
  Search for MED18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 181 2 3
p28b2 3
Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog (S.
Cerevisiae)1
Mediator Of RNA Polymerase II Transcription Subunit 182
Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog2
TRAP/Mediator Complex Subunit P28b2

External Ids:    HGNC: 259441   Entrez Gene: 547972   Ensembl: ENSG000001307727   OMIM: 6123845   UniProtKB: Q9BUE03   

Export aliases for MED18 gene to outside databases

Previous GC identifers: GC01P028340 GC01P028528 GC01P026912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED18 Gene:
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate
transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)

GeneCards Summary for MED18 Gene:
MED18 (mediator complex subunit 18) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot: MED18_HUMAN, Q9BUE0
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED18 gene promoter:
         MEF-2A   MEF-2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED18 promoter sequence
   Search Chromatin IP Primers for MED18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

MED18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028666:  view genomic region     (about GC identifiers)

Start:
28,655,513 bp from pter      End:
28,662,478 bp from pter
Size:
6,966 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MED18_HUMAN, Q9BUE0 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 18  
Size: 208 amino acids; 23663 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Secondary accessions: D3DPM1 Q9NXU9

Explore the universe of human proteins at neXtProt for MED18: NX_Q9BUE0

Explore proteomics data for MED18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys96
  • Modification sites at PhosphoSitePlus

  • See MED18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120822.1  NP_060108.2  

    ENSEMBL proteins: 
     ENSP00000362948   ENSP00000381963  
    Reactome Protein details: Q9BUE0

    MED18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MED18
    OriGene Protein Over-expression Lysate for MED18
    OriGene MassSpec for MED18
    OriGene Custom Protein Services for MED18
    GenScript Custom Purified and Recombinant Proteins Services for MED18
    Novus Biologicals MED18 Protein
    Novus Biologicals MED18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED18

     
    Search eBioscience for Proteins for MED18 

    MED18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MED18
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    Novus Biologicals MED18 Antibodies
    Abcam antibodies for MED18
    Cloud-Clone Corp. Antibodies for MED18
    ThermoFisher Antibody for MED18
    LSBio Antibodies in human, mouse, rat for MED18

    MED18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED18
    Cloud-Clone Corp. CLIAs for MED18
    Search eBioscience for ELISAs for MED18 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019095 Mediator_Med18_met/fun

    Graphical View of Domain Structure for InterPro Entry Q9BUE0

    ProtoNet protein and cluster: Q9BUE0

    UniProtKB/Swiss-Prot: MED18_HUMAN, Q9BUE0
    Similarity: Belongs to the Mediator complex subunit 18 family


    Find genes that share domains with MED18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED18_HUMAN, Q9BUE0
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding IPI12584197
         
    Find genes that share ontologies with MED18           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MED18:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Med18):
     behavior/neurological  hematopoietic system  immune system  other 

    Find genes that share phenotypes with MED18           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED18

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED18:
    hsa-mir-532-3p (MIRT037915)

    Block miRNA regulation of human, mouse, rat MED18 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MED18:
    hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidMED18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED18
    Predesigned siRNA for gene silencing in human, mouse, rat MED18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED18

    Clone
    Products:
         
    OriGene clones in human, mouse for MED18 (see all 12)
    OriGene ORF clones in mouse, rat for MED18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED18 (NM_017638)
    Sino Biological Human cDNA Clone for MED18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED18
    Addgene plasmids for MED18 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED18
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED18_HUMAN, Q9BUE0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016592mediator complex IDA14638676

    Find genes that share ontologies with MED18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED18 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3L1CAM interactions
    Developmental Biology0.63


    Find genes that share SuperPaths with MED18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for MED18
        Transcriptional regulation of white adipocyte differentiation
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED18
    Interactions:

        Search GeneGlobe Interaction Network for MED18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED18 (Q9BUE01, 3 ENSP000003629484) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED20Q9H9443, ENSP000002653504I2D: score=8 STRING: ENSP00000265350
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    CCNCP248633, ENSP000003582224I2D: score=1 STRING: ENSP00000358222
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with MED18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED18



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MED18 gene (2 alternative transcripts): 
    NM_001127350.1  NM_017638.2  

    Unigene Cluster for MED18:

    Mediator complex subunit 18
    Hs.479911  [show with all ESTs]
    Unigene Representative Sequence: NM_017638
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479574 ENST00000373842(uc021okc.1 uc001bpt.4 uc009vtg.3)
    ENST00000475655 ENST00000474683 ENST00000398997
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED18 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MED18:
    hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidMED18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED18
    Predesigned siRNA for gene silencing in human, mouse, rat MED18
    Clone
    Products:
         
    OriGene clones in human, mouse for MED18 (see all 12)
    OriGene ORF clones in mouse, rat for MED18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MED18 (NM_017638)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED18
    Addgene plasmids for MED18 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED18
    OriGene qSTAR qPCR primer pairs in human, mouse for MED18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED18
      QuantiTect SYBR Green Assays in human, mouse, rat MED18
      QuantiFast Probe-based Assays in human, mouse, rat MED18

    Additional mRNA sequence: 

    AB107222.1 AK000052.1 AK296130.1 BC002694.2 

    9 DOTS entries:

    DT.100739088  DT.411836  DT.100715866  DT.87011304  DT.91760753  DT.100739087  DT.100751294  DT.100023303 
    DT.100719787 

    Selected AceView cDNA sequences (see all 82):

    AI766858 BU189658 AI871116 BU163916 AW294223 AA445916 BM981941 BE858713 
    BQ055288 AL532844 AI423738 BG770708 AI160720 BQ063373 BQ061126 AA461545 
    BM458326 BQ687119 AI358830 BX385602 BX325357 BC002694 BE388452 BG708614 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MED18    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -           -                     
    SP2:                    -     -           -                     
    SP3:                                      -                     
    SP4:                          -                                 


    ECgene alternative splicing isoforms for MED18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATAAAGC
    MED18 Expression
    About this image


    MED18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    MED18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479911
        Custom PCR Arrays for MED18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED18
    OriGene qSTAR qPCR primer pairs in human, mouse for MED18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED18
    QuantiTect SYBR Green Assays in human, mouse, rat MED18
    QuantiFast Probe-based Assays in human, mouse, rat MED18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED18 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med181 , 5 mediator of RNA polymerase II transcription, subunit more5
    mediator complex subunit 181
    90.38(n)1
    98.56(a)1
      4 (65.40 cM)5
    672191  NM_026039.31  NP_080315.11 
     1324587315 
    chicken
    (Gallus gallus)
    Aves MED181 mediator complex subunit 18 78.69(n)
    92.31(a)
      100857707  XM_003642960.2  XP_003643008.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120002 Xenopus laevis transcribed sequence with moderate similarity more 74.45(n)    AW645495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638552 hypothetical protein MGC63855 75.44(n)   393306  BC053113.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED181 Mediator complex subunit 18 60.57(n)
    56.45(a)
      31140  NM_130592.4  NP_569948.3 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-181 mdt-18 43.64(n)
    32.47(a)
      183844  NM_059468.4  NP_491869.1 


    ENSEMBL Gene Tree for MED18 (if available)
    TreeFam Gene Tree for MED18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED18 (see all 142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8726411,2
    C,F,O,A,H--28653529(+) CAGCAC/GTTGAG 2 -- us2k1 tfbs324Minor allele frequency- N:0.00NS EA NA WA CSA 2880
    rs791781921,2
    C,F--28653548(+) ACTCTG/ACCCAA 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1381474281,2
    --28653569(+) CACCAA/GGTTGA 2 -- us2k10--------
    rs1891574611,2
    --28653849(+) GAGAAA/GAAAAG 2 -- us2k10--------
    rs728787251,2
    C--28654113(+) TCCTCC/TTTTTA 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1912845761,2
    --28654402(+) CCGCGA/CCTGTC 2 -- us2k10--------
    rs1410790311,2
    --28654408(+) CTGTCC/GTCTTT 2 -- us2k10--------
    rs1835190911,2
    --28654479(+) TAACTA/GGTCGT 2 -- us2k10--------
    rs44155991,2
    C,F,H--28654521(-) tgcaaC/Tagagg 2 -- us2k111Minor allele frequency- T:0.11NS EA NA WA 1308
    rs1450191201,2
    --28654686(+) TCACCA/GTGTTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MED18 (28655513 - 28662478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MED18:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv208n71CNV Gain21882294
    nsv870624CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED18
    DNA2.0 Custom Variant and Variant Library Synthesis for MED18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612384    OMIM disorders: --


    Find genes that share disorders with MED18           About GenesLikeMe


    Export disorders for MED18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED18 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with MED18)
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    1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S.... Conaway R.C. (Mol. Cell 2004)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    3. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (J. Biol. Chem. 2003)
    4. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Dermatomyositis presenting with focal scleroderma-like skin changes. (PubMed id 22622162)1 Chai Y....Shadle M.K. (J Clin Neuromuscul Dis 2012)
    9. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54797 HGNC: 25944 AceView: FLJ20045 Ensembl:ENSG00000130772 euGenes: HUgn54797
    ECgene: MED18 H-InvDB: MED18

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MED18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MED18 gene:
    Search GeneIP for patents involving MED18

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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