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Aliases for MED18 Gene

Aliases for MED18 Gene

  • Mediator Complex Subunit 18 2 3 4 5
  • P28b 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog 3
  • TRAP/Mediator Complex Subunit P28b 3

External Ids for MED18 Gene

Previous GeneCards Identifiers for MED18 Gene

  • GC01P028528
  • GC01P028666
  • GC01P026912

Summaries for MED18 Gene

Entrez Gene Summary for MED18 Gene

  • MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED18 Gene

MED18 (Mediator Complex Subunit 18) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED18 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED18 Gene

Genomics for MED18 Gene

Regulatory Elements for MED18 Gene

Promoters for MED18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED18 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED18 Gene

Chromosome:
1
Start:
28,329,002 bp from pter
End:
28,335,967 bp from pter
Size:
6,966 bases
Orientation:
Plus strand

Genomic View for MED18 Gene

Genes around MED18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED18 Gene

Proteins for MED18 Gene

  • Protein details for MED18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUE0-MED18_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 18
    Protein Accession:
    Q9BUE0
    Secondary Accessions:
    • D3DPM1
    • Q9NXU9

    Protein attributes for MED18 Gene

    Size:
    208 amino acids
    Molecular mass:
    23663 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED18 Gene

Proteomics data for MED18 Gene at MOPED

Post-translational modifications for MED18 Gene

  • Ubiquitination at Lys 96
  • Modification sites at PhosphoSitePlus

Other Protein References for MED18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MED18 Gene

Domains & Families for MED18 Gene

Gene Families for MED18 Gene

Protein Domains for MED18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUE0

UniProtKB/Swiss-Prot:

MED18_HUMAN :
  • Belongs to the Mediator complex subunit 18 family.
Family:
  • Belongs to the Mediator complex subunit 18 family.
genes like me logo Genes that share domains with MED18: view

Function for MED18 Gene

Molecular function for MED18 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IBA --
genes like me logo Genes that share ontologies with MED18: view
genes like me logo Genes that share phenotypes with MED18: view

Animal Models for MED18 Gene

MGI Knock Outs for MED18:

Animal Model Products

miRNA for MED18 Gene

miRTarBase miRNAs that target MED18

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED18 Gene

Localization for MED18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED18 Gene COMPARTMENTS Subcellular localization image for MED18 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IEA,IDA 14638676
genes like me logo Genes that share ontologies with MED18: view

Pathways & Interactions for MED18 Gene

genes like me logo Genes that share pathways with MED18: view

Gene Ontology (GO) - Biological Process for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription IBA --
genes like me logo Genes that share ontologies with MED18: view

No data available for SIGNOR curated interactions for MED18 Gene

Drugs & Compounds for MED18 Gene

No Compound Related Data Available

Transcripts for MED18 Gene

Unigene Clusters for MED18 Gene

Mediator complex subunit 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED18 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for MED18 Gene

GeneLoc Exon Structure for
MED18
ECgene alternative splicing isoforms for
MED18

Expression for MED18 Gene

mRNA expression in normal human tissues for MED18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED18 Gene

This gene is overexpressed in Lymph node (16.0), Tlymphocyte (9.8), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MED18 Gene



SOURCE GeneReport for Unigene cluster for MED18 Gene Hs.479911

genes like me logo Genes that share expression patterns with MED18: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MED18 Gene

Orthologs for MED18 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED18 36
  • 100 (a)
OneToOne
MED18 35
  • 99.84 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia MED18 35
  • 92.47 (n)
  • 97.12 (a)
MED18 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED18 36
  • 99 (a)
OneToOne
MED18 35
  • 92.79 (n)
  • 99.04 (a)
mouse
(Mus musculus)
Mammalia Med18 16
Med18 36
  • 99 (a)
OneToOne
Med18 35
  • 90.38 (n)
  • 98.56 (a)
oppossum
(Monodelphis domestica)
Mammalia MED18 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED18 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682988 35
  • 90.87 (n)
  • 99.04 (a)
chicken
(Gallus gallus)
Aves MED18 35
  • 78.69 (n)
  • 92.31 (a)
MED18 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12000 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med18 35
  • 71.63 (n)
  • 78.85 (a)
Str.6523 35
zebrafish
(Danio rerio)
Actinopterygii med18 36
  • 81 (a)
OneToOne
med18 35
  • 73.08 (n)
  • 80.77 (a)
zgc63855 35
African malaria mosquito
(Anopheles gambiae)
Insecta MED18_ANOGA 35
  • 58.2 (n)
  • 57.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED18 36
  • 49 (a)
OneToOne
MED18 35
  • 60.57 (n)
  • 56.45 (a)
worm
(Caenorhabditis elegans)
Secernentea mdt-18 35
  • 43.64 (n)
  • 32.47 (a)
mdt-18 36
  • 28 (a)
OneToOne
Species with no ortholog for MED18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED18 Gene

ENSEMBL:
Gene Tree for MED18 (if available)
TreeFam:
Gene Tree for MED18 (if available)

Paralogs for MED18 Gene

No data available for Paralogs for MED18 Gene

Variants for MED18 Gene

Sequence variations from dbSNP and Humsavar for MED18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1131732 -- 28,335,742(+) GCTTG(A/G)ACCCA utr-variant-3-prime
rs1131733 -- 28,335,770(+) TGACC(A/G)GAGAT utr-variant-3-prime
rs1131734 -- 28,335,774(+) cagag(A/G)tgacg utr-variant-3-prime
rs3753866 -- 28,328,558(+) gcgcg(C/T)cacca upstream-variant-2KB
rs4908397 -- 28,329,208(+) GATAC(A/G)TGTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MED18 Gene

Variant ID Type Subtype PubMed ID
dgv208n71 CNV Gain 21882294
nsv870624 CNV Gain 21882294

Variation tolerance for MED18 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED18 Gene

HapMap Linkage Disequilibrium report
MED18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED18 Gene

Disorders for MED18 Gene

Relevant External Links for MED18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED18

No disorders were found for MED18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED18 Gene

Publications for MED18 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. (PMID: 24882805) Tsai K.L. … Asturias F.J. (Cell 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for MED18 Gene

Sources for MED18 Gene

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