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Aliases for MED18 Gene

Aliases for MED18 Gene

  • Mediator Complex Subunit 18 2 3 4
  • P28b 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 18 3
  • TRAP/Mediator Complex Subunit P28b 3

External Ids for MED18 Gene

Previous GeneCards Identifiers for MED18 Gene

  • GC01P028528
  • GC01P028666
  • GC01P026912

Summaries for MED18 Gene

Entrez Gene Summary for MED18 Gene

  • MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED18 Gene

MED18 (Mediator Complex Subunit 18) is a Protein Coding gene. Diseases associated with MED18 include med23. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED18 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED18 Gene

Genomics for MED18 Gene

Regulatory Elements for MED18 Gene

Genomic Location for MED18 Gene

Start:
28,329,002 bp from pter
End:
28,335,967 bp from pter
Size:
6,966 bases
Orientation:
Plus strand

Genomic View for MED18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED18 Gene

Proteins for MED18 Gene

  • Protein details for MED18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUE0-MED18_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 18
    Protein Accession:
    Q9BUE0
    Secondary Accessions:
    • D3DPM1
    • Q9NXU9

    Protein attributes for MED18 Gene

    Size:
    208 amino acids
    Molecular mass:
    23663 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED18 Gene

Proteomics data for MED18 Gene at MOPED

Post-translational modifications for MED18 Gene

  • Ubiquitination at Lys96
  • Modification sites at PhosphoSitePlus

Other Protein References for MED18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED18 Gene

Domains for MED18 Gene

Protein Domains for MED18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUE0

UniProtKB/Swiss-Prot:

MED18_HUMAN :
  • Q9BUE0
Family:
  • Belongs to the Mediator complex subunit 18 family.
genes like me logo Genes that share domains with MED18: view

No data available for Gene Families for MED18 Gene

Function for MED18 Gene

Molecular function for MED18 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO) - Molecular Function for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 12584197
genes like me logo Genes that share ontologies with MED18: view

Phenotypes for MED18 Gene

genes like me logo Genes that share phenotypes with MED18: view

Animal Model Products

CRISPR Products

miRNA for MED18 Gene

miRTarBase miRNAs that target MED18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED18 Gene

Localization for MED18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED18 Gene COMPARTMENTS Subcellular localization image for MED18 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IDA 14638676
genes like me logo Genes that share ontologies with MED18: view

Pathways for MED18 Gene

genes like me logo Genes that share pathways with MED18: view

Gene Ontology (GO) - Biological Process for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MED18: view

Transcripts for MED18 Gene

Unigene Clusters for MED18 Gene

Mediator complex subunit 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED18

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED18 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for MED18 Gene

GeneLoc Exon Structure for
MED18
ECgene alternative splicing isoforms for
MED18

Expression for MED18 Gene

mRNA expression in normal human tissues for MED18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MED18 Gene

SOURCE GeneReport for Unigene cluster for MED18 Gene Hs.479911

genes like me logo Genes that share expressions with MED18: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED18 Gene

Orthologs for MED18 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED18 35
  • 99.84 (n)
  • 100 (a)
MED18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED18 35
  • 92.47 (n)
  • 97.12 (a)
MED18 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED18 35
  • 92.79 (n)
  • 99.04 (a)
MED18 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med18 35
  • 90.38 (n)
  • 98.56 (a)
Med18 16
Med18 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED18 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED18 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682988 35
  • 90.87 (n)
  • 99.04 (a)
chicken
(Gallus gallus)
Aves MED18 35
  • 78.69 (n)
  • 92.31 (a)
MED18 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12000 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med18 35
  • 71.63 (n)
  • 78.85 (a)
Str.6523 35
zebrafish
(Danio rerio)
Actinopterygii med18 35
  • 73.08 (n)
  • 80.77 (a)
med18 36
  • 81 (a)
OneToOne
zgc63855 35
African malaria mosquito
(Anopheles gambiae)
Insecta MED18_ANOGA 35
  • 58.2 (n)
  • 57.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED18 35
  • 60.57 (n)
  • 56.45 (a)
MED18 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-18 35
  • 43.64 (n)
  • 32.47 (a)
mdt-18 36
  • 28 (a)
OneToOne
Species with no ortholog for MED18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED18 Gene

ENSEMBL:
Gene Tree for MED18 (if available)
TreeFam:
Gene Tree for MED18 (if available)

Paralogs for MED18 Gene

No data available for Paralogs for MED18 Gene

Variants for MED18 Gene

Sequence variations from dbSNP and Humsavar for MED18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs872641 -- 28,327,018(+) CAGCA(C/G)TTGAG upstream-variant-2KB
rs1131732 -- 28,335,742(+) GCTTG(A/G)ACCCA utr-variant-3-prime
rs1131733 -- 28,335,770(+) TGACC(A/G)GAGAT utr-variant-3-prime
rs1131734 -- 28,335,774(+) cagag(A/G)tgacg utr-variant-3-prime
rs3753866 -- 28,328,558(+) gcgcg(C/T)cacca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MED18 Gene

Variant ID Type Subtype PubMed ID
dgv208n71 CNV Gain 21882294
nsv870624 CNV Gain 21882294

Relevant External Links for MED18 Gene

HapMap Linkage Disequilibrium report
MED18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED18 Gene

Disorders for MED18 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MED18 Gene including...

Search for MED18 Gene in MalaCards »
genes like me logo Genes that share disorders with MED18: view

No data available for UniProtKB/Swiss-Prot for MED18 Gene

Publications for MED18 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4
  2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4
  3. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 3 4
  4. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. (PMID: 14576168) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 3
  5. A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. (PMID: 14638676) Tomomori-Sato C. … Conaway J.W. (J. Biol. Chem. 2004) 3

Products for MED18 Gene

  • Addgene plasmids for MED18

Sources for MED18 Gene

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