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Aliases for MED18 Gene

Aliases for MED18 Gene

  • Mediator Complex Subunit 18 2 3 4 5
  • P28b 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 18 3
  • TRAP/Mediator Complex Subunit P28b 3

External Ids for MED18 Gene

Previous GeneCards Identifiers for MED18 Gene

  • GC01P028528
  • GC01P028666
  • GC01P026912

Summaries for MED18 Gene

Entrez Gene Summary for MED18 Gene

  • MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED18 Gene

MED18 (Mediator Complex Subunit 18) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED18 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED18 Gene

Genomics for MED18 Gene

Regulatory Elements for MED18 Gene

Enhancers for MED18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F028306 0.6 Ensembl ENCODE 13 -22.3 -22315 0.6 GLIS1 MED18 SESN2 RCC1 SNHG3 SNORA73B PRDX3P2 PTAFR ATPIF1 DNAJC8 PHACTR4
GH01F028301 0.2 ENCODE 12.9 -27.0 -26978 0.2 GATA3 STAT1 ADNP IKZF1 CEBPB ZBTB40 GABPA MED18 SESN2 ATPIF1 DNAJC8
GH01F028295 1 Ensembl ENCODE 12.9 -32.1 -32123 2.7 PKNOX1 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF48 YY1 SLC30A9 GLIS2 LOC105376896 SESN2 MED18 PHACTR4 PTAFR ATPIF1 DNAJC8
GH01F028266 0.6 Ensembl ENCODE 12.7 -61.8 -61812 0.7 HDGF ARNT CREB3L1 ZNF121 ELK1 GATA2 NCOA1 MBD2 SMARCA4 ETV4 MED18 ATPIF1 DNAJC8 PHACTR4 SESN2
GH01F028350 0.8 Ensembl ENCODE 12.5 +23.9 23926 4.3 HDGF ATF1 PKNOX1 ARNT ZNF48 GTF3C2 ELK1 FOS SP3 SP5 PHACTR4 GMEB1 ENSG00000237934 SNHG3 SNORA73B TRNAU1AP SNHG12 MED18 SESN2 RCC1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MED18 on UCSC Golden Path with GeneCards custom track

Promoters for MED18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001518693 198 2001 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for MED18 Gene

Chromosome:
1
Start:
28,329,002 bp from pter
End:
28,335,967 bp from pter
Size:
6,966 bases
Orientation:
Plus strand

Genomic View for MED18 Gene

Genes around MED18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED18 Gene

Proteins for MED18 Gene

  • Protein details for MED18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUE0-MED18_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 18
    Protein Accession:
    Q9BUE0
    Secondary Accessions:
    • D3DPM1
    • Q9NXU9

    Protein attributes for MED18 Gene

    Size:
    208 amino acids
    Molecular mass:
    23663 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED18 Gene

Post-translational modifications for MED18 Gene

  • Ubiquitination at Lys 96
  • Modification sites at PhosphoSitePlus

Other Protein References for MED18 Gene

No data available for DME Specific Peptides for MED18 Gene

Domains & Families for MED18 Gene

Gene Families for MED18 Gene

Protein Domains for MED18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUE0

UniProtKB/Swiss-Prot:

MED18_HUMAN :
  • Belongs to the Mediator complex subunit 18 family.
Family:
  • Belongs to the Mediator complex subunit 18 family.
genes like me logo Genes that share domains with MED18: view

Function for MED18 Gene

Molecular function for MED18 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IBA --
GO:0005515 protein binding IPI 12584197
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MED18: view
genes like me logo Genes that share phenotypes with MED18: view

Animal Models for MED18 Gene

MGI Knock Outs for MED18:

Animal Model Products

miRNA for MED18 Gene

miRTarBase miRNAs that target MED18

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED18

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED18 Gene

Localization for MED18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED18 Gene COMPARTMENTS Subcellular localization image for MED18 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IDA 14638676
GO:0070847 core mediator complex IBA --
genes like me logo Genes that share ontologies with MED18: view

Pathways & Interactions for MED18 Gene

genes like me logo Genes that share pathways with MED18: view

Gene Ontology (GO) - Biological Process for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006369 termination of RNA polymerase II transcription IBA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED18: view

No data available for SIGNOR curated interactions for MED18 Gene

Transcripts for MED18 Gene

Unigene Clusters for MED18 Gene

Mediator complex subunit 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MED18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED18 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for MED18 Gene

GeneLoc Exon Structure for
MED18
ECgene alternative splicing isoforms for
MED18

Expression for MED18 Gene

mRNA expression in normal human tissues for MED18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED18 Gene

This gene is overexpressed in Lymph node (16.0), Tlymphocyte (9.8), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MED18 Gene



NURSA nuclear receptor signaling pathways regulating expression of MED18 Gene:

MED18

SOURCE GeneReport for Unigene cluster for MED18 Gene:

Hs.479911
genes like me logo Genes that share expression patterns with MED18: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MED18 Gene

Orthologs for MED18 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED18 34 35
  • 99.84 (n)
oppossum
(Monodelphis domestica)
Mammalia MED18 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED18 34 35
  • 92.79 (n)
cow
(Bos Taurus)
Mammalia MED18 34 35
  • 92.47 (n)
rat
(Rattus norvegicus)
Mammalia LOC682988 34
  • 90.87 (n)
mouse
(Mus musculus)
Mammalia Med18 34 16 35
  • 90.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED18 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED18 34 35
  • 78.69 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia med18 34
  • 71.63 (n)
Str.6523 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12000 34
zebrafish
(Danio rerio)
Actinopterygii med18 34 35
  • 73.08 (n)
zgc63855 34
fruit fly
(Drosophila melanogaster)
Insecta MED18 34 35
  • 60.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta MED18_ANOGA 34
  • 58.2 (n)
worm
(Caenorhabditis elegans)
Secernentea mdt-18 34 35
  • 43.64 (n)
Species where no ortholog for MED18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED18 Gene

ENSEMBL:
Gene Tree for MED18 (if available)
TreeFam:
Gene Tree for MED18 (if available)

Paralogs for MED18 Gene

No data available for Paralogs for MED18 Gene

Variants for MED18 Gene

Sequence variations from dbSNP and Humsavar for MED18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10794514 -- 28,333,185(+) AGTAG(G/T)AAGTT intron-variant
rs111887712 -- 28,329,072(+) CTTCC(C/T)GGGCT upstream-variant-2KB, utr-variant-5-prime
rs112325286 -- 28,330,268(+) GAAAC(C/T)CCGTC intron-variant, upstream-variant-2KB
rs112714572 -- 28,329,787(+) AGAGA(G/T)AGAAC intron-variant, upstream-variant-2KB
rs1131732 -- 28,335,742(+) GCTTG(A/G)ACCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MED18 Gene

Variant ID Type Subtype PubMed ID
nsv545916 CNV gain 21841781

Variation tolerance for MED18 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED18 Gene

Disorders for MED18 Gene

Relevant External Links for MED18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED18

No disorders were found for MED18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED18 Gene

Publications for MED18 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4 64
  2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 64
  3. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 3 4 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MED18 Gene

Sources for MED18 Gene

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