Aliases for MED18 Gene
External Ids for MED18 Gene
Previous GeneCards Identifiers for MED18 Gene
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
GeneCards Summary for MED18 Gene
MED18 (Mediator Complex Subunit 18) is a Protein Coding gene. Diseases associated with MED18 include med23. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.
UniProtKB/Swiss-Prot for MED18 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors