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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED18 Gene

protein-coding   GIFtS: 46
GCID: GC01P028666

mediator complex subunit 18

(Previous names: mediator of RNA polymerase II transcription, subunit 18...)
  Search for MED18
in our new
 Human Malady Compendium 
Biological research products
for MED18
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 181 2 3     Mediator Of RNA Polymerase II Transcription Subunit 182
P28b1     Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog2
FLJ200451     TRAP/Mediator Complex Subunit P28b2
Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 259441   Entrez Gene: 547972   Ensembl: ENSG000001307727   OMIM: 6123845   UniProtKB: Q9BUE03   

Export aliases for MED18 gene to outside databases

Previous GC identifers: GC01P028340 GC01P028528 GC01P026912


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED18:
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate
transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)

UniProtKB/Swiss-Prot: MED18_HUMAN, Q9BUE0
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED18 gene promoter:
         MEF-2A   MEF-2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED18 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

MED18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028666:  view genomic region     (about GC identifiers)

Start:
28,655,513 bp from pter      End:
28,662,478 bp from pter
Size:
6,966 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED18_HUMAN, Q9BUE0 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 18  
Size: 208 amino acids; 23663 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Secondary accessions: D3DPM1 Q9NXU9

Explore the universe of human proteins at neXtProt for MED18: NX_Q9BUE0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUE0

  • MED18 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120822.1  NP_060108.2  

    ENSEMBL proteins: 
     ENSP00000362948   ENSP00000381963  
    Reactome Protein details: Q9BUE0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): MED18
    OriGene Protein Over-expression Lysate (see all 2): MED18
    OriGene Custom Protein Services for MED18 
    GenScript Custom Purified and Recombinant Proteins Services for MED18
    Novus Biologicals MED18 Protein
    Novus Biologicals MED18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED18

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016592mediator complex IDA14638676


    MED18 for ontologies           About GeneDecksing



    MED18 Antibody Products: 
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    Novus Biologicals MED18 Antibodies
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    Uscn Antibodies for MED18
    Search ThermoFisher Antibodies for MED18

    Assay Products for MED18: 
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    Uscn ELISAs and CLIAs for MED18


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MED18 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019095 Mediator_Med18_met/fun

    Graphical View of Domain Structure for InterPro Entry Q9BUE0

    ProtoNet protein and cluster: Q9BUE0

    UniProtKB/Swiss-Prot: MED18_HUMAN, Q9BUE0
    Similarity: Belongs to the Mediator complex subunit 18 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MED18_HUMAN, Q9BUE0
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED18
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MED18:
    hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidMED18 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED18 (see all 4)
    OriGene shRNA RFP: MED18
    OriGene siRNA: MED18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED18

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MED18

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED18 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED18 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MED18 (NM_017638)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED18 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED18
    Search LifeMap BioReagents cell lines for MED18

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED18

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding IPI12584197


    MED18 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MED18:
     Increased G1 DNA content 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Med18):
     behavior/neurological  hematopoietic system  immune system  other 

    MED18 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation1.00
    2Axon guidance
    Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for MED18
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation



    MED18 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/92 Interacting proteins for MED18 (Q9BUE01, 3 ENSP000003629484) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED20Q9H9443, ENSP000002653504I2D: score=8 STRING: ENSP00000265350
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    CCNCP248633, ENSP000003582224I2D: score=1 STRING: ENSP00000358222
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED18
    Search CenterWatch for drugs/clinical trials and news about MED18 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED18 gene (2 alternative transcripts): 
    NM_001127350.1  NM_017638.2  

    Unigene Cluster for MED18:

    Mediator complex subunit 18
    Hs.479911  [show with all ESTs]
    Unigene Representative Sequence: NM_017638
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479574 ENST00000373842(uc021okc.1 uc001bpt.4 uc009vtg.3)
    ENST00000475655 ENST00000474683 ENST00000398997

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED18
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MED18:
    hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidMED18 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED18 (see all 4)
    OriGene shRNA RFP: MED18
    OriGene siRNA: MED18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED18
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED18 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED18 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MED18 (NM_017638)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED18 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED18
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED18
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED18

    Additional cDNA sequence: 

    AB107222.1 AK000052.1 AK296130.1 BC002694.2 

    9 DOTS entries:

    DT.100739088  DT.411836  DT.100715866  DT.87011304  DT.91760753  DT.100739087  DT.100751294  DT.100023303 
    DT.100719787 

    24/82 AceView cDNA sequences (see all 82):

    BU163916 BQ055288 BC002694 BQ063373 BU189658 BG770708 AI423738 BM981941 
    BQ061126 AI766858 BE858713 AW294223 AA445916 BQ687119 BM458326 BX325357 
    AI160720 AL532844 AA461545 AI871116 BX385602 AI358830 BI918729 BI833075 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MED18    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -           -                     
    SP2:                    -     -           -                     
    SP3:                                      -                     
    SP4:                          -                                 


    ECgene alternative splicing isoforms for MED18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTAATAAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MED18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED18

    SOURCE GeneReport for Unigene cluster: Hs.479911
        SABiosciences Custom PCR Arrays for MED18
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED18
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED18 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med181 , 5 mediator of RNA polymerase II transcription, subunit more1, 5 90.38(n)1
    98.56(a)1
      4 (65.40 cM)5
    672191  NM_026039.31  NP_080315.11 
     1324587315 
    chicken
    (Gallus gallus)
    Aves LOC1008577071 mediator of RNA polymerase II transcription subunit more 78.69(n)
    92.31(a)
      100857707  XM_003642960.1  XP_003643008.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120002 Xenopus laevis transcribed sequence with moderate similarity more 74.45(n)    AW645495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638552 hypothetical protein MGC63855 75.44(n)   393306  BC053113.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED181 Mediator complex subunit 18 60.57(n)
    56.45(a)
      31140  NM_130592.4  NP_569948.3 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-181 Protein MDT-18 44.08(n)
    33.88(a)
      183844  NM_059468.3  NP_491869.1 


    ENSEMBL Gene Tree for MED18 (if available)
    TreeFam Gene Tree for MED18 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 NCBI SNPs in MED18 are shown (see all 129    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8726411,2
    C,F,O,A,H,--28653529(+) CAGCAC/GTTGAG 2 -- us2k1 tfbs324Minor allele frequency- N:0.00NS EA NA WA CSA 2880
    rs791781921,2
    C,F,--28653548(+) ACTCTG/ACCCAA 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1381474281,2
    --28653569(+) CACCAA/GGTTGA 2 -- us2k10--------
    rs1891574611,2
    --28653849(+) GAGAAA/GAAAAG 2 -- us2k10--------
    rs728787251,2
    C,--28654113(+) TCCTCC/TTTTTA 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1912845761,2
    --28654402(+) CCGCGA/CCTGTC 2 -- us2k10--------
    rs1410790311,2
    --28654408(+) CTGTCC/GTCTTT 2 -- us2k10--------
    rs1835190911,2
    --28654479(+) TAACTA/GGTCGT 2 -- us2k10--------
    rs44155991,2
    C,F,H,--28654521(-) tgcaaC/Tagagg 2 -- us2k111Minor allele frequency- T:0.11NS EA NA WA 1308
    rs1450191201,2
    --28654686(+) TCACCA/GTGTTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MED18 (28655513 - 28662478 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MED18: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED18
    DNA2.0 Custom Variant and Variant Library Synthesis for MED18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MED18 for disorders           About MalaCards

    MED18 for disorders           About GeneDecksing

    OMIM gene information: 612384    OMIM disorders: --


    Export disorders for MED18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED18 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with MED18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S....Conaway R.C. (2004)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    3. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2 Sato S....Conaway J.W. (2003)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Dermatomyositis presenting with focal scleroderma-like skin changes. (PubMed id 22622162)1 Chai Y....Shadle M.K. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)1 Krebs A.R....Tora L. (2010)
    9. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
    10. Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression. (PubMed id 18250152)1 Young E.T....Biddick R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54797 HGNC: 25944 AceView: FLJ20045 Ensembl:ENSG00000130772 euGenes: HUgn54797
    ECgene: MED18 H-InvDB: MED18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED18 gene:
    Search GeneIP for patents involving MED18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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