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Aliases for MED17 Gene

Aliases for MED17 Gene

  • Mediator Complex Subunit 17 2 3 4
  • DRIP80 3 4 6
  • TRAP80 3 4 6
  • CRSP6 3 4 6
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 6, 77kDa 2 3
  • Thyroid Hormone Receptor-Associated Protein Complex 80 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 80 KDa Component 3 4
  • Activator-Recruited Cofactor 77 KDa Component 3 4
  • Transcriptional Coactivator CRSP77 3 4
  • CRSP Complex Subunit 6 3 4
  • CRSP77 3 6
  • ARC77 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 6 (77kD) 2
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 6 4
  • Mediator Of RNA Polymerase II Transcription Subunit 17 3
  • DRIP77 4

External Ids for MED17 Gene

Previous Symbols for MED17 Gene

  • CRSP6

Summaries for MED17 Gene

Entrez Gene Summary for MED17 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED17 Gene

MED17 (Mediator Complex Subunit 17) is a Protein Coding gene. Diseases associated with MED17 include microcephaly, postnatal progressive, with seizures and brain atrophy and infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for MED17 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED17 Gene

Genomics for MED17 Gene

Genomic Location for MED17 Gene

Start:
93,784,227 bp from pter
End:
93,814,695 bp from pter
Size:
30,469 bases
Orientation:
Plus strand

Genomic View for MED17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED17 Gene

Proteins for MED17 Gene

  • Protein details for MED17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVC6-MED17_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 17
    Protein Accession:
    Q9NVC6
    Secondary Accessions:
    • B3KN07
    • Q9HA81
    • Q9UNP7
    • Q9Y2W0
    • Q9Y660

    Protein attributes for MED17 Gene

    Size:
    651 amino acids
    Molecular mass:
    72890 Da
    Quaternary structure:
    • Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2.
    SequenceCaution:
    • Sequence=AAD30856.1; Type=Frameshift; Positions=333, 335, 341, 346; Evidence={ECO:0000305};

    Alternative splice isoforms for MED17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED17 Gene

Proteomics data for MED17 Gene at MOPED

Post-translational modifications for MED17 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123, Lys178, and Lys623

Other Protein References for MED17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED17 Gene

Domains for MED17 Gene

Protein Domains for MED17 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MED17_HUMAN
Family:
  • Belongs to the Mediator complex subunit 17 family.:
    • Q9NVC6
genes like me logo Genes that share domains with MED17: view

No data available for Gene Families for MED17 Gene

Function for MED17 Gene

Molecular function for MED17 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IDA 12037571
GO:0004872 receptor activity IDA 12218053
GO:0005515 protein binding IPI 12584197
genes like me logo Genes that share ontologies with MED17: view

Phenotypes for MED17 Gene

GenomeRNAi human phenotypes for MED17:
genes like me logo Genes that share phenotypes with MED17: view

miRNA for MED17 Gene

miRTarBase miRNAs that target MED17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED17 Gene

Localization for MED17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED17 Gene COMPARTMENTS Subcellular localization image for MED17 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 9989412
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IDA 10198638
genes like me logo Genes that share ontologies with MED17: view

Pathways for MED17 Gene

genes like me logo Genes that share pathways with MED17: view

Pathways by source for MED17 Gene

Gene Ontology (GO) - Biological Process for MED17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 9989412
GO:0006366 transcription from RNA polymerase II promoter --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0019827 stem cell maintenance IEA --
genes like me logo Genes that share ontologies with MED17: view

Transcripts for MED17 Gene

Unigene Clusters for MED17 Gene

Mediator complex subunit 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED17 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: -
SP5: - -
SP6: -
SP7:
SP8: -
SP9: -
SP10:

ExUns: 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MED17 Gene

GeneLoc Exon Structure for
MED17
ECgene alternative splicing isoforms for
MED17

Expression for MED17 Gene

mRNA expression in normal human tissues for MED17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED17 Gene

SOURCE GeneReport for Unigene cluster for MED17 Gene Hs.444931

mRNA Expression by UniProt/SwissProt for MED17 Gene

Q9NVC6-MED17_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with MED17: view

Orthologs for MED17 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED17 36
  • 99.44 (n)
  • 99.39 (a)
MED17 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED17 36
  • 92.73 (n)
  • 96.77 (a)
MED17 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED17 36
  • 92.06 (n)
  • 96.62 (a)
MED17 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med17 36
  • 86.44 (n)
  • 95.99 (a)
Med17 16
Med17 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED17 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Med17 36
  • 86.49 (n)
  • 96.15 (a)
chicken
(Gallus gallus)
Aves MED17 36
  • 80.25 (n)
  • 91.07 (a)
MED17 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED17 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med17 36
  • 75.27 (n)
  • 85.92 (a)
Str.10192 36
zebrafish
(Danio rerio)
Actinopterygii med17 36
  • 69.94 (n)
  • 80.22 (a)
MED17 37
  • 75 (a)
OneToOne
zgc73307 36
African malaria mosquito
(Anopheles gambiae)
Insecta MED17_ANOGA 36
  • 49.68 (n)
  • 44.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED17 36
  • 50.24 (n)
  • 45.38 (a)
MED17 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-17 36
  • 41.28 (n)
  • 28.09 (a)
mdt-17 37
  • 21 (a)
OneToOne
Species with no ortholog for MED17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED17 Gene

ENSEMBL:
Gene Tree for MED17 (if available)
TreeFam:
Gene Tree for MED17 (if available)

Paralogs for MED17 Gene

No data available for Paralogs for MED17 Gene

Variants for MED17 Gene

Sequence variations from dbSNP and Humsavar for MED17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs588644 -- 93,786,507(+) tgtcg(A/G)ccagg intron-variant
rs591709 -- 93,787,149(+) TGGCT(C/T)ACGTC intron-variant
rs592526 -- 93,806,354(-) TCTTC(C/T)TTCTA intron-variant
rs596202 -- 93,789,732(+) tgggg(A/G)accaa intron-variant
rs606087 -- 93,789,476(+) CTAAT(A/G)CAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED17 Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
nsv898181 CNV Gain 21882294
nsv898182 CNV Gain 21882294
nsv832232 CNV Gain 17160897

Relevant External Links for MED17 Gene

HapMap Linkage Disequilibrium report
MED17
Human Gene Mutation Database (HGMD)
MED17

Disorders for MED17 Gene

(1) OMIM Diseases for MED17 Gene (603810)

UniProtKB/Swiss-Prot

MED17_HUMAN
  • Microcephaly, postnatal progressive, with seizures and brain atrophy (MCPHSBA) [MIM:613668]: A disorder characterized by postnatal progressive microcephaly and severe developmental retardation associated with cerebral and cerebellar atrophy. Infants manifest swallowing difficulties leading to failure to thrive, jitteriness, poor visual fixation, truncal arching, seizures. There is no acquisition of developmental milestones and patients suffer from marked spasticity and profound retardation. Progressive microcephaly becomes evident few months after birth. {ECO:0000269 PubMed:20950787}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with MED17: view

Publications for MED17 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4
  2. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PMID: 10198638) Ito M. … Roeder R.G. (Mol. Cell 1999) 2 3 4
  3. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PMID: 10235266) Rachez C. … Freedman L.P. (Nature 1999) 3 4
  4. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PMID: 10235267) Naeaer A.M. … Tjian R. (Nature 1999) 3 4
  5. Role of metazoan mediator proteins in interferon-responsive transcription. (PMID: 12509459) Lau J.F. … Horvath C.M. (Mol. Cell. Biol. 2003) 3 4

Products for MED17 Gene

  • Addgene plasmids for MED17

Sources for MED17 Gene

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