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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MED17 Gene

protein-coding GIFtS: 52
GCID: GC11P093517

mediator complex subunit 17

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbol: CRSP6)

Explore 8 diseases affiliated with
MED17 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mediator Complex Subunit 17¹ ² ³		Vitamin D3 Receptor-Interacting Protein Complex 80 KDa Component² ³
CRSP6¹ ² ³ ⁵		ARC77² ³
DRIP80¹ ² ³ ⁵		CRSP Complex Subunit 6² ³
TRAP80¹ ² ³ ⁵		Cofactor Required For Sp1 Transcriptional Activation, Subunit 6 (77kD)¹
CRSP77¹ ² ⁵		Mediator Of RNA Polymerase II Transcription Subunit 17²
Cofactor Required For Sp1 Transcriptional Activation, Subunit 6, 77kDa¹ ²		DRIP77³
Activator-Recruited Cofactor 77 KDa Component² ³		Trap80³
Thyroid Hormone Receptor-Associated Protein Complex 80 KDa Component² ³		Cofactor Required For Sp1 Transcriptional Activation Subunit 6³
Transcriptional Coactivator CRSP77² ³

External Ids:	HGNC: 2375¹	Entrez Gene: 9440²	Ensembl: ENSG00000042429⁷	OMIM: 603810⁵	UniProtKB: Q9NVC6³

Export aliases for MED17 gene to outside databases

Previous GC identifers: GC11P093158 GC11P089594

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED17:

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional

enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA

polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1

activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a

component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with

TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MED17_HUMAN, Q9NVC6

Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA

polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory

proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct

interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex

with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MED17 gene promoter:
Sox5 POU3F1 HNF-4alpha2 LCR-F1 HNF-4alpha1 PPAR-alpha PPAR-gamma1 FOXO1a PPAR-gamma2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MED17 promoter sequence

Search SABiosciences Chromatin IP Primers for MED17

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED17

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21

MED17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED17 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P093517: view genomic region (about GC identifiers)

Start:	93,517,393 bp from pter	End:	93,547,861 bp from pter
Size:	30,469 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MED17_HUMAN, Q9NVC6 (See protein sequence)

Recommended Name: Mediator of RNA polymerase II transcription subunit 17

Size: 651 amino acids; 72890 Da

Subunit: Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1,

MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20,

MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13,

CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less

active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the

Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Interacts with STAT2

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAD30856.1; Type=Frameshift; Positions=333, 335, 341, 346;

Secondary accessions: B3KN07 Q9HA81 Q9UNP7 Q9Y2W0 Q9Y660

Alternative splicing: 2 isoforms: Q9NVC6-1 Q9NVC6-2

Explore the universe of human proteins at neXtProt for MED17: NX_Q9NVC6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NVC6

MED17 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004259.3

ENSEMBL proteins:

ENSP00000251871 ENSP00000434459 ENSP00000431524 ENSP00000433090 ENSP00000433626

Reactome Protein details: Q9NVC6
Human Recombinant Protein Products for MED17:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MED17 OriGene Custom Protein Services for MED17
	GenScript Custom Purified and Recombinant Proteins Services for MED17
	Novus Biologicals MED17 Proteins Novus Biologicals MED17 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MED17

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	10235267
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IDA	9989412
GO:0016592	mediator complex	IDA	14638676

MED17 for ontologies About GeneDecksing

MED17 Antibody Products:

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	Novus Biologicals MED17 Antibodies
	Abcam antibodies for MED17
	Uscn Antibodies for MED17
	Search ThermoFisher Antibodies for MED17

Assay Products for MED17:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MED17
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MED17

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MED17 for domains About GeneDecksing

1 InterPro domain/family:

IPR019313 Mediator_Med17

Graphical View of Domain Structure for InterPro Entry Q9NVC6

ProtoNet protein and cluster: Q9NVC6

UniProtKB/Swiss-Prot: MED17_HUMAN, Q9NVC6

Similarity: Belongs to the Mediator complex subunit 17 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MED17_HUMAN, Q9NVC6

Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA

polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory

proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct

interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex

with RNA polymerase II and the general transcription factors

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001104	RNA polymerase II transcription cofactor activity	IDA	10198638
GO:0003712	transcription cofactor activity	IDA	12218053
GO:0003713	transcription coactivator activity	IDA	12037571
GO:0004872	receptor activity	IDA	12218053
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	NAS	10235266

MED17 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MED17:

Decreased POU5F1-GFP protein e

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MED17

miRNA Products:		OriGene 3'-UTR Clone: MED17 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED17
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MED17 (see all 23):
		hsa-miR-142-5p hsa-miR-607 hsa-miR-875-3p hsa-miR-106a hsa-miR-340 hsa-miR-218 hsa-miR-93 hsa-miR-330-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MED17 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED17 (see all 4) OriGene shRNA RFP: MED17 OriGene siRNA: MED17
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED17
		Sirion Biotech Custom design and validation of potent shRNA sequences against MED17

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MED17
			Sirion Biotech Customized adenovirus for overexpression of MED17 Sirion Biotech Customized adenovirus for potent knockdown of MED17

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED17 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED17 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MED17 (NM_004268)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED17
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED17

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MED17
		Search LifeMap BioReagents cell lines for MED17
		Sirion Biotech Customized stable knockdown cell line services for MED17 Sirion Biotech Customized inducible knockdown cell line services for MED17 Sirion Biotech Customized stable overexpressing cell line services for MED17 Sirion Biotech Customized inducible overexpressing cell line services for MED17

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED17

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

HIV Infection

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

0.28

Transcription_Ligand-Dependent Transcription of Retinoid-Target genes

0.28

Transcriptional Regulation of White Adipocyte Differentiation

Transcriptional Regulation of White Adipocyte Differentiation

1.00

Axon guidance

Developmental Biology

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MED17

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 GeneGo (Thomson Reuters) Pathway for MED17

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

4 Reactome Pathways for MED17

	Developmental Biology
	Transcriptional Regulation of White Adipocyte Differentiation
	Generic Transcription Pathway
	Gene Expression

MED17 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MED17

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/123 Interacting proteins for MED17 (Q9NVC6^{2, 3} ENSP00000251871⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 123)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KAT2A	Q92830²^,³, ENSP00000225916⁴	MINT-6744331 I2D: score=1 STRING: ENSP00000225916
MED1	Q15648²^,³, ENSP00000300651⁴	MINT-6744331 I2D: score=1 STRING: ENSP00000300651
MED14	O60244²^,³, ENSP00000323720⁴	MINT-6744331 I2D: score=1 STRING: ENSP00000323720
TRRAP	Q9Y4A5²^,³, ENSP00000347733⁴	MINT-6744331 I2D: score=1 STRING: ENSP00000347733
MED12	Q93074²^,³, ENSP00000363193⁴	MINT-6744331 I2D: score=1 STRING: ENSP00000363193

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA	9989412
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0010467	gene expression	TAS	--
GO:0019827	stem cell maintenance	IEA	--
GO:0030518	intracellular steroid hormone receptor signaling pathway	IDA	11867769

MED17 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MED17
Search CenterWatch for drugs/clinical trials and news about MED17

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MED17 gene:

NM_004268.4

Unigene Cluster for MED17:

Mediator complex subunit 17

Hs.444931 [show with all ESTs]

Unigene Representative Sequence: NM_004268

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000251871(uc001pem.4) ENST00000530819(uc001pel.2) ENST00000533359

ENST00000533133 ENST00000528786 ENST00000525026 ENST00000533367 ENST00000507258

ENST00000531920 ENST00000525613 ENST00000529626

miRNA Products:		OriGene 3'-UTR Clone: MED17 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED17
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MED17 (see all 23):
		hsa-miR-142-5p hsa-miR-607 hsa-miR-875-3p hsa-miR-106a hsa-miR-340 hsa-miR-218 hsa-miR-93 hsa-miR-330-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MED17 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED17 (see all 4) OriGene shRNA RFP: MED17 OriGene siRNA: MED17
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED17
		Sirion Biotech Custom design and validation of potent shRNA sequences against MED17

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED17 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED17 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MED17 (NM_004268)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED17
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED17

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED17 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MED17
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED17
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED17

Additional cDNA sequence:

AF104254.1 AF105421.1 AF117657.2 AK001674.1 AK023209.1 AK299702.1 BC021101.1

17 DOTS entries:

DT.444693 DT.97794521 DT.100689424 DT.120738262 DT.100754659 DT.91755009 DT.100766972 DT.120738114

DT.120738151 DT.120738132 DT.100754655 DT.120738173 DT.120738179 DT.70102891 DT.100775947 DT.120738187

DT.91843376

24/197 AceView cDNA sequences (see all 197):

BX115998 AA135940 NM_004268 BX099106 AI439124 BU621496 AA832410 AW473841

AI733527 AU126099 CR604067 AI095773 BM719539 AW242072 AA903578 BP375633

AI911664 AW135298 AI921279 CB054273 CA868018 AA565681 AW080471 BC021101

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MED17 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	^	12a	·	12b	·	12c	^	13	^
SP1:							-								-						-		-				-										-								-
SP2:																					-		-		-		-										-								-
SP3:															-						-		-		-		-										-
SP4:																																					-
SP5:																							-				-

ExUns:	14a	·	14b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MED17

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MED17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See MED17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MED17

SOURCE GeneReport for Unigene cluster: Hs.444931

UniProtKB/Swiss-Prot: MED17_HUMAN, Q9NVC6

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Array including MED17:

Nuclear Receptors & Coregulators in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED17 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED17

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED17

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MED17 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Med17^{1 , 5}	mediator complex subunit 17^{1, 5}	86.44(n)¹ 95.99(a)¹		9 (4.74 cM)⁵ 234959¹ NM_144933.1¹ NP_659182.1¹ 15260352⁵
chicken (Gallus gallus)	Aves	MED17¹	mediator complex subunit 17	79.99(n) 90.82(a)		419000 NM_001006280.1 NP_001006280.1
lizard (Anolis carolinensis)	Reptilia	MED17⁶	--	89(a)	1 ↔ 1	3(196080759-196094400)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10192²	Transcribed sequence with weak similarity to protein more	77.33(n)		142000488
zebrafish (Danio rerio)	Actinopterygii	zgc73307²	hypothetical protein MGC73307	76.13(n)		393756 AJ006838.1
fruit fly (Drosophila melanogaster)	Insecta	MED17¹	Mediator complex subunit 17	49.89(n) 45.15(a)		42175 NM_142429.2 NP_650686.1
worm (Caenorhabditis elegans)	Secernentea	mdt-17⁶	--	20(a)	1 ↔ 1	V(20250784-20267209)

ENSEMBL Gene Tree for MED17 (if available)
TreeFam Gene Tree for MED17 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141044343^1,2		--	93515409(+)	`GTTGGC/GAACAA`	1	--	us2k¹		0	--	--	--	--
rs192394425^1,2		--	93515598(+)	`TACTTC/TCAGGA`	1	--	us2k¹		0	--	--	--	--
rs184985010^1,2		--	93515629(+)	`AGGTTA/GTGCTT`	1	--	us2k¹		0	--	--	--	--
rs188962901^1,2		--	93515673(+)	`AACCTA/GCAAAT`	1	--	us2k¹		0	--	--	--	--
rs664257^1,2	C,F,A,H	--	93515709(-)	`CACAGA/GATGAA`	1	--	us2k¹		23		NS EA NA WA CSA	2337
rs115487359^1,2	F	--	93515771(+)	`GAAGAT/CGTTAT`	1	--	us2k¹		1		WA	118
rs149817048^1,2		--	93515894(+)	`TTTTGA/GCATAC`	1	--	us2k¹		0	--	--	--	--
rs1428919^1,2	C,F,O,A,H	--	93516016(+)	`CAACTT/AACCTT`	1	--	us2k¹ tfbs³		16		NS EA NA WA	928
rs639100^1,2	C	--	93516096(+)	`GCTTTA/GCTTAT`	1	--	us2k¹		12		NA WA CSA EA	374
rs662070^1,2	C	--	93516204(-)	`AAAAAA/TTTTTT`	1	--	us2k¹		6		NA WA EA	364

HapMap Linkage Disequilibrium report for MED17 (93517393 - 93547861 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MED17: --
Human Gene Mutation Database (HGMD): MED17

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED17

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MED17 for disorders           About GeneDecksing

OMIM gene information: 603810
OMIM disorders: 613668
UniProtKB/Swiss-Prot: MED17_HUMAN, Q9NVC6

Defects in MED17 are the cause of microcephaly postnatal progressive with seizures and brain atrophy (MCPHSBA)

[MIM:613668]. It is a disorder characterized by postnatal progressive microcephaly and severe developmental

retardation associated with cerebral and cerebellar atrophy. Infants manifest swallowing difficulties leading to

failure to thrive, jitteriness, poor visual fixation, truncal arching, seizures. There is no acquisition of

developmental milestones and patients suffer from marked spasticity and profound retardation. Progressive microcephaly

becomes evident few months after birth

8 diseases for MED17: About MalaCards

microcephaly, postnatal progressive, with seizures and brain atrophy thyroiditis microcephaly conjunctivitis

seizures spasticity cerebritis cholesterol

Export disorders for MED17 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MED17 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with MED17)

Utopia: connect your pdf to the dynamic
world of online information

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)^{1, 2, 3} Ryu S.... Tjian R. (1999)
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PubMed id 10198638)^{1, 2, 3} Ito M.... Roeder R.G. (1999)
Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex. (PubMed id 20950787)^{1, 2} Kaufmann R.... Elpeleg O. (2010)
MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)^{1, 2} Zhang X....Roeder R.G. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)^{1, 2} Sato S....Conaway R.C. (2004)
Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)^{1, 2} Sato S....Conaway J.W. (2003)
Role of metazoan mediator proteins in interferon-responsive transcription. (PubMed id 12509459)^{1, 2} Lau J.F.... Horvath C.M. (2003)
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)^{1, 2} Rachez C.... Freedman L.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9440	HGNC: 2375	AceView: CRSP6	Ensembl:ENSG00000042429	euGenes: HUgn9440
ECgene: MED17	H-InvDB: MED17

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MED17	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MED17 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MED17 gene:
Search GeneIP for patents involving MED17

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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MED17 Gene

mediator complex subunit 17

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MED17 Gene

mediator complex subunit 17

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