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Aliases for MED16 Gene

Aliases for MED16 Gene

  • Mediator Complex Subunit 16 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 95 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 92 KDa Component 3 4
  • Thyroid Hormone Receptor-Associated Protein 5 3 4
  • TRAP95 3 4
  • THRAP5 3 4
  • DRIP92 3 4
  • Thyroid Hormone Receptor-Associated Protein, 95-KD Subunit 3
  • Thyroid Hormone Receptor Associated Protein 5 2

External Ids for MED16 Gene

Previous HGNC Symbols for MED16 Gene

  • THRAP5

Previous GeneCards Identifiers for MED16 Gene

  • GC19M000819
  • GC19M000640
  • GC19M000884
  • GC19M000889
  • GC19M000906

Summaries for MED16 Gene

GeneCards Summary for MED16 Gene

MED16 (Mediator Complex Subunit 16) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Thyroid hormone signaling pathway. GO annotations related to this gene include receptor activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for MED16 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED16 Gene

Genomics for MED16 Gene

Regulatory Elements for MED16 Gene

Enhancers for MED16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MED16 on UCSC Golden Path with GeneCards custom track

Promoters for MED16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED16 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED16 Gene

Chromosome:
19
Start:
867,630 bp from pter
End:
893,218 bp from pter
Size:
25,589 bases
Orientation:
Minus strand

Genomic View for MED16 Gene

Genes around MED16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED16 Gene

Proteins for MED16 Gene

  • Protein details for MED16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X0-MED16_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 16
    Protein Accession:
    Q9Y2X0
    Secondary Accessions:
    • Q6PJT2
    • Q96AD4
    • Q96I35
    • Q9Y652

    Protein attributes for MED16 Gene

    Size:
    877 amino acids
    Molecular mass:
    96793 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAD31087.1; Type=Frameshift; Positions=609; Evidence={ECO:0000305};

    Alternative splice isoforms for MED16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED16 Gene

Proteomics data for MED16 Gene at MOPED

Post-translational modifications for MED16 Gene

  • Ubiquitination at Lys 26, Lys 149, Lys 158, Lys 252, Lys 284, Lys 338, Lys 574, Lys 745, Lys 808, and Lys 817
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MED16 Gene

Domains & Families for MED16 Gene

Gene Families for MED16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2X0

UniProtKB/Swiss-Prot:

MED16_HUMAN :
  • Belongs to the Mediator complex subunit 16 family.
  • Contains 9 WD repeats.
Family:
  • Belongs to the Mediator complex subunit 16 family.
Similarity:
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with MED16: view

Function for MED16 Gene

Molecular function for MED16 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with MED16: view
genes like me logo Genes that share phenotypes with MED16: view

Animal Model Products

miRNA for MED16 Gene

miRTarBase miRNAs that target MED16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED16 Gene

Localization for MED16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED16 Gene COMPARTMENTS Subcellular localization image for MED16 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MED16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IDA 10198638
genes like me logo Genes that share ontologies with MED16: view

Pathways & Interactions for MED16 Gene

genes like me logo Genes that share pathways with MED16: view

Pathways by source for MED16 Gene

Gene Ontology (GO) - Biological Process for MED16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 10198638
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:2000273 positive regulation of receptor activity IDA 10198638
genes like me logo Genes that share ontologies with MED16: view

No data available for SIGNOR curated interactions for MED16 Gene

Drugs & Compounds for MED16 Gene

No Compound Related Data Available

Transcripts for MED16 Gene

Unigene Clusters for MED16 Gene

Mediator complex subunit 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - - - - - - -
SP7: - -
SP8:

ExUns: 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MED16 Gene

GeneLoc Exon Structure for
MED16
ECgene alternative splicing isoforms for
MED16

Expression for MED16 Gene

mRNA expression in normal human tissues for MED16 Gene

Protein differential expression in normal tissues from HIPED for MED16 Gene

This gene is overexpressed in Platelet (54.9) and Breast (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED16 Gene



SOURCE GeneReport for Unigene cluster for MED16 Gene Hs.365207

genes like me logo Genes that share expression patterns with MED16: view

Protein tissue co-expression partners for MED16 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED16 Gene

Orthologs for MED16 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED16 35
  • 88.14 (n)
  • 93.86 (a)
MED16 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED16 35
  • 89.42 (n)
  • 94.61 (a)
MED16 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med16 35
  • 85.65 (n)
  • 92.8 (a)
Med16 16
Med16 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED16 35
  • 97.92 (n)
  • 97.64 (a)
MED16 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med16 35
  • 86.02 (n)
  • 92.93 (a)
oppossum
(Monodelphis domestica)
Mammalia MED16 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED16 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED16 35
  • 78.23 (n)
  • 84.8 (a)
MED16 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED16 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med16 35
  • 71.46 (n)
  • 81.57 (a)
Str.15997 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16367 35
zebrafish
(Danio rerio)
Actinopterygii med16 35
  • 71.36 (n)
  • 76.59 (a)
wufc29h12 35
med16 36
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1586 35
fruit fly
(Drosophila melanogaster)
Insecta MED16 35
  • 45.75 (n)
  • 33.38 (a)
MED16 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
Species with no ortholog for MED16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED16 Gene

ENSEMBL:
Gene Tree for MED16 (if available)
TreeFam:
Gene Tree for MED16 (if available)

Paralogs for MED16 Gene

No data available for Paralogs for MED16 Gene

Variants for MED16 Gene

Sequence variations from dbSNP and Humsavar for MED16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34859566 - 871,044(-) ACGGC(C/T)TCGCC reference, missense
rs13090 - 868,115(-) ATCCA(A/C/G)AGGAC reference, missense
rs7256798 -- 870,213(+) ACTAA(A/G)GGCAG intron-variant
rs7257260 -- 870,592(+) AGAGG(A/G)TGAAT intron-variant
rs8100009 -- 871,048(+) AGGCC(A/G)TCGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MED16 Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3549n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3551n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3558n71 CNV Loss 21882294
nsv910320 CNV Loss 21882294
dgv3559n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
dgv3561n71 CNV Loss 21882294
nsv910329 CNV Loss 21882294
dgv3562n71 CNV Loss 21882294
nsv910332 CNV Loss 21882294
nsv2385 CNV Insertion 18451855
nsv910338 CNV Gain+Loss 21882294
nsv910343 CNV Loss 21882294
nsv513505 CNV Insertion 21212237
esv1010169 CNV Insertion 20482838
esv2273959 CNV Deletion 18987734
esv2717801 CNV Deletion 23290073
esv2717802 CNV Deletion 23290073
esv3473 CNV Deletion 18987735
esv28908 CNV Gain 19812545
esv2717803 CNV Deletion 23290073
esv2717804 CNV Deletion 23290073
esv2717805 CNV Deletion 23290073
esv2717808 CNV Deletion 23290073
esv2670297 CNV Deletion 23128226
esv2717809 CNV Deletion 23290073
esv2717810 CNV Deletion 23290073

Variation tolerance for MED16 Gene

Residual Variation Intolerance Score: 1.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MED16 Gene

Disorders for MED16 Gene

Relevant External Links for MED16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED16

No disorders were found for MED16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED16 Gene

Publications for MED16 Gene

  1. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PMID: 10198638) Ito M. … Roeder R.G. (Mol. Cell 1999) 2 3 4 67
  2. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PMID: 10235266) Rachez C. … Freedman L.P. (Nature 1999) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for MED16 Gene

Sources for MED16 Gene

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