MED16 Gene
protein-coding GIFtS: 52
GCID: GC19M000884
|
|
mediator complex subunit 16(Previous name: thyroid hormone receptor associated protein 5 )
(Previous symbol: THRAP5)
| |
Aliases
for MED16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mediator Complex Subunit 161 2 3 | | Vitamin D3 Receptor-Interacting Protein Complex 92 KDa Component2 3 | | DRIP921 2 3 | | Thyroid Hormone Receptor Associated Protein 51 | | THRAP51 2 3 | | Mediator Of RNA Polymerase II Transcription Subunit 162 | | TRAP951 2 | | Thyroid Hormone Receptor-Associated Protein, 95-KD Subunit2 | | Thyroid Hormone Receptor-Associated Protein 52 3 | | Trap953 | | Thyroid Hormone Receptor-Associated Protein Complex 95 KDa Component2 3 | | |
Export aliases for MED16 gene to outside databasesPrevious GC identifers: GC19M000819 GC19M000640 |
Summaries
for MED16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MED16_HUMAN, Q9Y2X0Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors
Gene Wiki entry for MED16
|
Genomic Views
for MED16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MED16 gene promoter:
TBP NF-1/L NF-1 MIF-1 AP-2gamma E47 AP-2beta AP-2alpha ATF6 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for MED16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3MED16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M000884: view genomic region
(about GC identifiers)
Start:
|
867,961 bp from pter |
End:
|
893,218 bp from pter |
Size:
|
25,258 bases |
Orientation:
|
minus strand |
|
Proteins
for MED16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MED16_HUMAN, Q9Y2X0 (See
protein sequence)Recommended Name: Mediator of RNA polymerase II transcription subunit 16 Size: 877 amino acids; 96793 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinctmodule termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module insupporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinctsubunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Sequence caution: Sequence=AAD31087.1; Type=Frameshift; Positions=609;
Secondary accessions: Q6PJT2 Q96AD4 Q96I35 Q9Y652Alternative splicing: 5 isoforms: Q9Y2X0-1 Q9Y2X0-2 Q9Y2X0-3 Q9Y2X0-4 Q9Y2X0-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MED16: NX_Q9Y2X0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2X0
MED16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005472.2
ENSEMBL proteins: ENSP00000308528 ENSP00000464810 ENSP00000379153 ENSP00000466868 ENSP00000465762 ENSP00000465823 ENSP00000465827 ENSP00000325612 ENSP00000269814 Reactome Protein details: Q9Y2X0
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MED16 for ontologies About GeneDecksing
MED16 Antibody Products:
Assay Products for MED16: |
Protein
Domains /
Families
for MED16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MED16 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2X0ProtoNet protein and cluster: Q9Y2X0 UniProtKB/Swiss-Prot: MED16_HUMAN, Q9Y2X0Similarity: Belongs to the Mediator complex subunit 16 familySimilarity: Contains 5 WD repeats |
Function
for MED16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MED16_HUMAN, Q9Y2X0Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED16 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MED16 (NM_005481) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MED16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED16 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
MED16 for ontologies About GeneDecksing
|
Pathways & Interactions
for MED16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | HIV Infection | | | 3 | Transcriptional Regulation of White Adipocyte Differentiation | | | 4 | Axon guidance | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MED16
1  GeneGo (Thomson Reuters) Pathway for MED16
4 
Reactome Pathways for MED16
MED16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/625 Interacting proteins for MED16 (Q9Y2X02, 3 ENSP000003256124) via UniProtKB, MINT, STRING, and/or I2D (see all 625)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter |
NAS | 10198638 | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 10198638 | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0030518 | intracellular steroid hormone receptor signaling pathway |
IDA | 11867769 |
MED16 for ontologies About GeneDecksing
|
Drugs & Compounds
for MED16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MED16
Search CenterWatch for drugs/clinical trials and news about MED16
|
Transcripts
for MED16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MED16 gene: NM_005481.2 Unigene Cluster for MED16: Mediator complex subunit 16 Hs.365207 [show with all ESTs]Unigene Representative Sequence: AF1069349 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312090(uc002lqf.3) ENST00000589119 ENST00000395808(uc002lqe.3)
ENST00000592943 ENST00000586017 ENST00000592373 ENST00000586342 ENST00000325464(uc002lqd.1)
ENST00000269814(uc010drw.2 uc010xfv.1 uc010xfw.1 uc010xfx.1 uc010xfy.1 uc010xga.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED16 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MED16 (NM_005481) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MED16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED16 |
Additional cDNA sequence: AF106934.1 AF121228.1 AL137732.1 BC004554.1 BC007853.2 BC011841.1 BC017282.2 EU392448.1 EU392449.1 EU392450.1 EU392451.1 EU392452.1 EU392453.1 EU392454.1 EU392455.1 EU392456.1 EU392457.1 EU392458.1 EU392459.1 EU392460.1 EU392461.1 EU392462.1 EU392463.1 EU392464.1 EU392465.1 EU392466.1 EU392467.1 EU392468.1 EU392469.1 EU392470.1 EU392471.1 EU392472.1 EU392473.1 EU392474.1 EU392475.1 EU392476.1 EU392477.1 EU392478.1 EU392479.1 EU392480.1 EU392481.1 EU392482.1 EU392483.1 EU392484.1 EU392485.1 EU392486.1 EU392487.1 EU392488.1 EU392489.1 EU392490.1 EU392491.1 EU392492.1 EU392493.1 EU392494.1 EU392495.1 EU392496.1 EU392497.1 EU392498.1 16 DOTS entries: DT.99958172 DT.95222596 DT.97783369 DT.100790175 DT.444361 DT.100032907 DT.100790173 DT.100790174 DT.95176134 DT.121485371 DT.92433460 DT.92433462 DT.92433464 DT.95176147 DT.121485389 DT.99981147 24/273 AceView cDNA sequences (see all 273): BU615705 BU931076 AI797059 AI356578 AW005452 BM545730 AW339934 CA776661 BE874359 AI807370 BC007853 BG388392 BQ271525 CK825531 AI971791 BU949769 AI951661 AI475781 CA307939 CD672782 AI346872 AI568577 BU501822 CD242705
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MED16 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | |
| ExUns: | 19 | ^ | 20a | · | 20b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for MED16
|
Expression
for MED16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MED16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MED16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MED16
SOURCE GeneReport for Unigene cluster: Hs.365207
SABiosciences Expression via Pathway-Focused PCR Array including MED16:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED16 |
Orthologs
for MED16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MED16 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Med161 , 5 |
mediator complex subunit 161, 5 |
85.71(n)1
92.92(a)1 |
|
10 (39.72 cM)5
2161541 NM_198107.21 NP_932775.21
798947085 |
chicken
(Gallus gallus) |
Aves |
MED161 |
mediator complex subunit 16 |
78.23(n)
84.8(a) |
|
420099 XM_418220.3 XP_418220.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MED166 |
-- |
88(a) |
1 ↔ 1 |
AAWZ02041879(1089-3534) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.163672 |
Xenopus laevis transcribed sequence with strong similarity more |
76.13(n) |
|
BJ033809.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc29h122 |
Transcribed sequence with weak similarity to protein more |
76.9(n) |
|
57048457 |
fruit fly
(Drosophila melanogaster) |
Insecta |
MED161 |
Mediator complex subunit 16 |
45.92(n)
32.98(a) |
|
37535 NM_137806.3 NP_611650.2 |
ENSEMBL Gene Tree for MED16 (if available)
TreeFam Gene Tree for MED16 (if available) |
Paralogs
for MED16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MED16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MED16 (867961 - 893218 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for MED16
5 CNVs: 73268 30055 33960 30054 30056
2 Indels: 41377 45815 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED16 |
|
Disorders
/ Diseases
for MED16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MED16 for disorders About GeneDecksing
OMIM gene information: 604062
OMIM disorders: --
3  diseases for MED16: About MalaCardsthyroiditis bulimia nervosa retinitis
Export disorders for MED16 gene to outside databases
|
Publications
for MED16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MED16 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with MED16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PubMed id 10198638)1, 2, 3 Ito M.... Roeder R.G. (1999)
- Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2, 3 Rachez C.... Freedman L.P. (1999)
- MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for MED16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MED16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MED16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MED16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MED16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MED16 gene:
Search GeneIP for patents involving MED16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MED16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MED16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED16 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MED16 | | OriGene 3'-UTR Clone for MED16 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MED16 | | OriGene Custom Protein Services for MED16 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MED16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED16 |
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| | | | Search Tocris compounds for MED16 |
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 | | | MED16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED16 |
|  |  |  | | | | Search ThermoFisher Antibodies for MED16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED16 |
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