Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MED15 Gene

Aliases for MED15 Gene

  • Mediator Complex Subunit 15 2 3 4 5
  • PC2 (Positive Cofactor 2, Multiprotein Complex) Glutamine/Q-Rich-Associated Protein 2 3
  • Activator-Recruited Cofactor 105 KDa Component 3 4
  • Trinucleotide Repeat-Containing Gene 7 Protein 3 4
  • PC2 Glutamine/Q-Rich-Associated Protein 3 4
  • Trinucleotide Repeat Containing 7 2 3
  • TPA-Inducible Gene 1 Protein 3 4
  • CTG Repeat Protein 7a 3 4
  • ARC105 3 4
  • PCQAP 3 4
  • TNRC7 3 4
  • CTG7A 3 4
  • TIG-1 3 4
  • TIG1 3 4
  • Positive Cofactor 2, Glutamine/Q-Rich-Associated Protein 3
  • Positive Cofactor 2 Glutamine/Q-Rich-Associated Protein 4
  • Mediator Of RNA Polymerase II Transcription Subunit 15 3
  • PC2-Glutamine-Rich-Associated Protein 3
  • Activator-Recruited Cofactor, 105-KD 3
  • TPA Inducible Protein 3
  • TPA Inducible Gene-1 3
  • CAG7A 3

External Ids for MED15 Gene

Previous HGNC Symbols for MED15 Gene

  • TNRC7
  • PCQAP

Previous GeneCards Identifiers for MED15 Gene

  • GC22P019191
  • GC22P020850
  • GC22P004129

Summaries for MED15 Gene

Entrez Gene Summary for MED15 Gene

  • The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for MED15 Gene

MED15 (Mediator Complex Subunit 15) is a Protein Coding gene. Diseases associated with MED15 include Chromosome 22Q11.2 Microduplication Syndrome and Velocardiofacial Syndrome. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED15 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.

Gene Wiki entry for MED15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED15 Gene

Genomics for MED15 Gene

Regulatory Elements for MED15 Gene

Enhancers for MED15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F020562 1.8 FANTOM5 Ensembl ENCODE 29.4 +71.5 71525 9.2 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF610 SCARF2 MED15 RPL7AP70 THAP7-AS1 DGCR8 LOC105372938 THAP7 SERPIND1 LOC100420177 RPL8P5
GH22F020548 1.7 FANTOM5 Ensembl ENCODE 29.7 +57.8 57777 11.0 HDGF PKNOX1 ARNT CREB3L1 MLX SIN3A ARID4B FEZF1 YBX1 YY1 THAP7-AS1 SCARF2 MED15 LOC100420177 THAP7 PI4KA LOC105372938 ABHD17AP4 KLHL22 DGCR8
GH22F020543 1.3 Ensembl ENCODE 28.6 +49.6 49649 3.6 HDGF ATF1 PKNOX1 ARNT ELK1 GATA2 KLF13 MCM3 CREB3 NFIL3 SCARF2 MED15 ABHD17AP4 KLHL22 THAP7-AS1 RNU6-225P THAP7 SERPIND1 ZNF74 LOC105372938
GH22F020506 1.5 FANTOM5 ENCODE 20.8 +13.6 13590 5.8 HDGF WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 SCARF2 TBX1 MED15 ABHD17AP4 THAP7-AS1 THAP7 RPL7AP70 LOC100420177 ZNF74 LOC105372938
GH22F020529 1.4 Ensembl ENCODE 16.7 +36.4 36445 6.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 MED15 ABHD17AP4 RPL7AP70 ZNF74 LOC105372938 CCDC74BP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED15 on UCSC Golden Path with GeneCards custom track

Promoters for MED15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084471 -13 2601 CREB3L1 FEZF1 YBX1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 SP3 MEF2D

Genomic Location for MED15 Gene

Chromosome:
22
Start:
20,495,913 bp from pter
End:
20,587,632 bp from pter
Size:
91,720 bases
Orientation:
Plus strand

Genomic View for MED15 Gene

Genes around MED15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED15 Gene

Proteins for MED15 Gene

  • Protein details for MED15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RN5-MED15_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 15
    Protein Accession:
    Q96RN5
    Secondary Accessions:
    • D3DX31
    • D3DX32
    • O15413
    • Q6IC31
    • Q8NF16
    • Q96CT0
    • Q96IH7
    • Q9P1T3

    Protein attributes for MED15 Gene

    Size:
    788 amino acids
    Molecular mass:
    86753 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with SMAD2, SMAD3, SREBF1 and SREBF2. Interacts with WWTR1. Interacts with TRIM11.
    SequenceCaution:
    • Sequence=AAC12944.1; Type=Frameshift; Positions=13, 600, 749; Evidence={ECO:0000305}; Sequence=BAB85034.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAC03446.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MED15 Gene

    Alternative splice isoforms for MED15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED15 Gene

Post-translational modifications for MED15 Gene

No data available for DME Specific Peptides for MED15 Gene

Domains & Families for MED15 Gene

Protein Domains for MED15 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96RN5

UniProtKB/Swiss-Prot:

MED15_HUMAN :
  • Belongs to the Mediator complex subunit 15 family.
Family:
  • Belongs to the Mediator complex subunit 15 family.
genes like me logo Genes that share domains with MED15: view

Function for MED15 Gene

Molecular function for MED15 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
UniProtKB/Swiss-Prot Induction:
By 12-O-tetradecanoylphorbol-13-acetate (TPA).

Gene Ontology (GO) - Molecular Function for MED15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0003712 transcription cofactor activity IEA --
GO:0005515 protein binding IPI 16799563
genes like me logo Genes that share ontologies with MED15: view
genes like me logo Genes that share phenotypes with MED15: view

Animal Model Products

miRNA for MED15 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED15 Gene

Localization for MED15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED15 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED15 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MED15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with MED15: view

Pathways & Interactions for MED15 Gene

genes like me logo Genes that share pathways with MED15: view

Gene Ontology (GO) - Biological Process for MED15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with MED15: view

No data available for SIGNOR curated interactions for MED15 Gene

Drugs & Compounds for MED15 Gene

(1) Drugs for MED15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MED15: view

Transcripts for MED15 Gene

Unigene Clusters for MED15 Gene

Mediator complex subunit 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^
SP1:
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: - - -
SP14: - -
SP15: -
SP16: - - - -
SP17:
SP18:
SP19:
SP20:

ExUns: 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19: - -
SP20:

Relevant External Links for MED15 Gene

GeneLoc Exon Structure for
MED15
ECgene alternative splicing isoforms for
MED15

Expression for MED15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MED15 Gene

Protein differential expression in normal tissues from HIPED for MED15 Gene

This gene is overexpressed in Placenta (19.9), Plasma (10.0), and CD8 Tcells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED15 Gene



Protein tissue co-expression partners for MED15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MED15 Gene:

MED15

SOURCE GeneReport for Unigene cluster for MED15 Gene:

Hs.517421

mRNA Expression by UniProt/SwissProt for MED15 Gene:

Q96RN5-MED15_HUMAN
Tissue specificity: Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney.
genes like me logo Genes that share expression patterns with MED15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MED15 Gene

Orthologs for MED15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED15 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED15 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED15 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med15 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MED15 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED15 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11806 34
African clawed frog
(Xenopus laevis)
Amphibia ARC105 34
zebrafish
(Danio rerio)
Actinopterygii med15 35
  • 59 (a)
OneToOne
Dr.7497 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.986 34
fruit fly
(Drosophila melanogaster)
Insecta MED15 35
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for MED15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED15 Gene

ENSEMBL:
Gene Tree for MED15 (if available)
TreeFam:
Gene Tree for MED15 (if available)

Paralogs for MED15 Gene

genes like me logo Genes that share paralogs with MED15: view

No data available for Paralogs for MED15 Gene

Variants for MED15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MED15 Gene

MED15_HUMAN-Q96RN5
The poly-Gln region from amino acids 235-262 of PCQAP is polymorphic. There are from 15 to 18 repeats in the Italian population.

Sequence variations from dbSNP and Humsavar for MED15 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1044102 -- 20,587,521(+) CCACT(C/T)TGGGC utr-variant-3-prime
rs1044106 -- 20,587,542(+) ACCCT(C/T)TGGTG utr-variant-3-prime
rs1044108 -- 20,587,552(+) GAGAA(A/G)AGGTC utr-variant-3-prime
rs1044109 -- 20,587,582(+) ACCCC(A/C)CCATC utr-variant-3-prime
rs1075339 -- 20,552,080(+) TCTTC(A/G)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED15 Gene

Variant ID Type Subtype PubMed ID
nsv953033 CNV deletion 24416366
nsv834139 CNV loss 17160897
nsv834138 CNV loss 17160897
nsv834136 CNV loss 17160897
nsv828956 CNV gain 20364138
nsv828954 CNV gain 20364138
nsv821342 CNV deletion 20802225
nsv819580 CNV gain 19587683
nsv588298 CNV gain 21841781
nsv588293 CNV gain 21841781
nsv523162 CNV loss 19592680
nsv509810 CNV insertion 20534489
nsv436864 CNV insertion 17901297
nsv3562 CNV deletion 18451855
nsv3561 CNV insertion 18451855
nsv1062650 CNV gain 25217958
nsv1056614 CNV loss 25217958
esv3893438 CNV gain 25118596
esv3647295 CNV loss 21293372
esv3647294 CNV loss 21293372
esv2763693 CNV gain 21179565
esv25802 CNV gain 19812545
dgv7994n54 CNV gain 21841781
dgv7993n54 CNV gain 21841781
dgv4483n100 CNV gain 25217958

Variation tolerance for MED15 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED15

Disorders for MED15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MED15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 22q11.2 microduplication syndrome
  • chromosome 22q11.2 duplication syndrome
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MED15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MED15

Genetic Association Database (GAD)
MED15
Human Genome Epidemiology (HuGE) Navigator
MED15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED15
genes like me logo Genes that share disorders with MED15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED15 Gene

Publications for MED15 Gene

  1. Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. (PMID: 11414760) Berti L. … Meisterernst M. (Genomics 2001) 2 3 4 22 64
  2. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. (PMID: 16799563) Yang F. … Naeaer A.M. (Nature 2006) 3 4 22 64
  3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4 64
  4. Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. (PMID: 12497610) De Luca A. … Novelli G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 22 46 64
  5. A novel glutamine-rich putative transcriptional adaptor protein (TIG- 1), preferentially expressed in placental and bone-marrow tissues. (PMID: 11024300) Abraham S. … Solomon W.B. (Gene 2000) 2 3 4 64

Products for MED15 Gene

Sources for MED15 Gene

Content
Loading form....