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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED15 Gene

protein-coding   GIFtS: 57
GCID: GC22P020850

mediator complex subunit 15

(Previous names: trinucleotide repeat containing 7, PC2 (positive cofactor...)
(Previous symbols: TNRC7, PCQAP)
 Explore 11 diseases affiliated with
MED15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MED15    

Aliases
for MED15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mediator Complex Subunit 151 2 3     CTG7A2 3
PCQAP1 2 3 5     CTG Repeat Protein 7a2 3
TIG-11 2 3     PC2 Glutamine/Q-Rich-Associated Protein2 3
TNRC71 2 3     TPA-Inducible Gene 1 Protein2 3
ARC1052 3 5     Arc1051
TIG12 3 5     Activator-Recruited Cofactor, 105-KD2
CAG7A1 2     Mediator Of RNA Polymerase II Transcription Subunit 152
PC2 (Positive Cofactor 2, Multiprotein Complex) Glutamine/Q-Rich-Associated
Protein1 2
     PC2-Glutamine-Rich-Associated Protein2
Trinucleotide Repeat Containing 71 2     Positive Cofactor 2, Glutamine/Q-Rich-Associated Protein2
Activator-Recruited Cofactor 105 KDa Component2 3     TPA Inducible Gene-12
Positive Cofactor 2 Glutamine/Q-Rich-Associated Protein2 3     TPA Inducible Protein2
Trinucleotide Repeat-Containing Gene 7 Protein2 3     

External Ids:    HGNC: 142481   Entrez Gene: 515862   Ensembl: ENSG000000999177   OMIM: 6073725   UniProtKB: Q96RN53   

Export aliases for MED15 gene to outside databases

Previous GC identifers: GC22P019191 GC22P004129


Summaries
for MED15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MED15:
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a
transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats
and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MED15_HUMAN, Q96RN5
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation.
Positively regulates the Nodal signaling pathway

Gene Wiki entry for MED15


Genomic Views
for MED15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED15 gene promoter:
         SRF   SRF (504 AA)   Lmo2   Ik-3   POU2F1   NRF-2   FOXO4   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MED15 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

MED15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED15 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P020850:  view genomic region     (about GC identifiers)

Start:
 20,850,200 bp from pter      End:
 20,941,919 bp from pter
Size:
 91,720 bases      Orientation:
 plus strand

Proteins
for MED15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MED15_HUMAN, Q96RN5 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 15  
Size: 788 amino acids; 86753 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with SMAD2, SMAD3, SREBF1 and
SREBF2. Interacts with WWTR1. Interacts with TRIM11
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAC12944.1; Type=Frameshift; Positions=13, 600, 749; Sequence=BAB85034.1; Type=Miscellaneous
discrepancy; Note=Several sequencing errors; Sequence=BAC03446.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MED15:
2GUT (3D)    
Secondary accessions: D3DX31 D3DX32 O15413 Q6IC31 Q8NF16 Q96CT0 Q96IH7 Q9P1T3
Alternative splicing: 3 isoforms:  Q96RN5-1   Q96RN5-2   Q96RN5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MED15: NX_Q96RN5

Post-translational modifications:

  • Ubiquitinated by TRIM11, leading to proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96RN5

    • MED15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003891.1  NP_056973.2  

    ENSEMBL proteins: 
     ENSP00000407742   ENSP00000409578   ENSP00000392738   ENSP00000391108   ENSP00000408794  
     ENSP00000292733   ENSP00000263205   ENSP00000384344   ENSP00000372434   ENSP00000413636  
     ENSP00000410173   ENSP00000390498   ENSP00000408742   ENSP00000415778   ENSP00000413603  
     ENSP00000396461   ENSP00000408875   ENSP00000416109   ENSP00000443137   ENSP00000416425  
     ENSP00000444604  
    Reactome Protein details: Q96RN5
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MED15
    OriGene Protein Over-expression Lysate: MED15
    OriGene Custom Protein Services for MED15 
    GenScript Custom Purified and Recombinant Proteins Services for MED15
    Novus Biologicals MED15 Proteins
    Novus Biologicals MED15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED15

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005794Golgi apparatus IDA--
    GO:0016592mediator complex IEA--


    MED15 for ontologies           About GeneDecksing



    MED15 Antibody Products: 
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    Uscn Antibodies for MED15
    ThermoFisher Antibodies for MED15

    Assay Products for MED15: 
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    GenScript Custom Assay Services for MED15
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    Uscn ELISAs and CLIAs for MED15

    Protein Domains /
    Families
    for MED15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MED15 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019087 Mediator_Med15_met

    Graphical View of Domain Structure for InterPro Entry Q96RN5

    ProtoNet protein and cluster: Q96RN5

    UniProtKB/Swiss-Prot: MED15_HUMAN, Q96RN5
    Similarity: Belongs to the Mediator complex subunit 15 family


    Function
    for MED15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MED15_HUMAN, Q96RN5
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation.
    Positively regulates the Nodal signaling pathway
    Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): MED15
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED15
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MED15 (see all 20):
    hsa-miR-3685 hsa-miR-125a-5p hsa-miR-301a hsa-miR-298 hsa-miR-125b hsa-miR-130b hsa-miR-3155b hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmid: MED15 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED15 (see all 4)
    OriGene shRNA RFP: MED15
    OriGene siRNA: MED15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED15

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MED15

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED15 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MED15 (NM_001003891)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED15 

    Cell Line
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    Search LifeMap BioReagents cell lines for MED15

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED15

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0005515protein binding IPI16799563


    MED15 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MED15:
     Decreased Wnt reporter activit 


    Pathways & Interactions
    for MED15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Signal transduction_Activin A signaling regulation0.96
    3Transcriptional Regulation of White Adipocyte Differentiation
    		Transcriptional Regulation of White Adipocyte Differentiation1.00
    4Regulation of nuclear SMAD2/3 signaling
    		Regulation of nuclear SMAD2/3 signaling1.00
    5Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MED15
        Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for MED15
        Signal transduction Activin A signaling regulation

    1 BioSystems Pathway for MED15 
        Regulation of nuclear SMAD2/3 signaling

    4        Reactome Pathways for MED15
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for MED15 (Q96RN51, 2, 3 ENSP000002632054) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK8P493362, 3, ENSP000003709384MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000370938
    MED1Q156482, 3, ENSP000003006514MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000300651
    SMAD2Q157962, 3, ENSP000002621604MINT-17344 MINT-17343 I2D: score=3 STRING: ENSP00000262160
    MLLT6P551982, 3, ENSP000003164264MINT-66283 I2D: score=5 STRING: ENSP00000316426
    ATXN1P542532, 3, ENSP000002447694MINT-2873442 I2D: score=3 STRING: ENSP00000244769
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--


    MED15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MED15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MED15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED15
    1 Novoseek chemical compound relationship for MED15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 47 2 11414760 (1), 12497610 (1)

    Search CenterWatch for drugs/clinical trials and news about MED15 

    Transcripts
    for MED15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MED15 gene (2 alternative transcripts): 
    NM_001003891.1  NM_015889.3  

    Unigene Cluster for MED15:

    Mediator complex subunit 15
    Hs.517421  [show with all ESTs]
    Unigene Representative Sequence: NM_001003891
    18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000445987 ENST00000444094 ENST00000486656 ENST00000414658 ENST00000433831(uc002zsn.1)
    ENST00000432052 ENST00000292733(uc002zsq.3 uc010gso.3 uc002zsr.3 uc011ahs.2)
    ENST00000263205(uc002zsp.3 uc011ahu.2) ENST00000477824 ENST00000406969
    ENST00000382974 ENST00000441501 ENST00000438962 ENST00000445189 ENST00000451058
    ENST00000473028 ENST00000457322 ENST00000428629

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MED15
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED15
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MED15 (see all 20):
    hsa-miR-3685 hsa-miR-125a-5p hsa-miR-301a hsa-miR-298 hsa-miR-125b hsa-miR-130b hsa-miR-3155b hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmid: MED15 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED15 (see all 4)
    OriGene shRNA RFP: MED15
    OriGene siRNA: MED15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED15
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED15 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MED15 (NM_001003891)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED15 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED15
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED15

    Additional cDNA sequence: 

    AF056191.1 AF328769.1 AK074230.1 AK074268.1 AK090465.1 AK294540.1 AK294734.1 AK297284.1 
    AK297789.1 AK315540.1 AL832923.1 BC003078.1 BC007529.1 BC013985.2 BC017110.1 CR456537.1 
    U80745.1 

    24/49 DOTS entries (see all 49):

    DT.100686525  DT.95158731  DT.120668347  DT.100774255  DT.100793193  DT.120667758  DT.87000953  DT.100793189 
    DT.100836246  DT.100766669  DT.102843155  DT.91932860  DT.120667791  DT.120668270  DT.75171660  DT.95255972 
    DT.92443094  DT.100793187  DT.101981829  DT.101981830  DT.101985526  DT.120668557  DT.120668198  DT.120667802 

    24/437 AceView cDNA sequences (see all 437):

    CR611888 BM809783 NM_001003891 AK000003 BU162939 BU179739 BQ945388 BU615725 
    BU846138 BX370958 BG390937 CB850729 BU627718 CF995849 CA310604 CD245923 
    BQ691126 BQ690944 BQ931939 NM_015889 BM764227 BU185760 BQ688264 BM709022 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for MED15 (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^
    SP1:                                                                                                                                                            
    SP2:                                -           -           -     -     -     -           -     -     -                                                         
    SP3:                                                        -     -     -     -     -     -     -     -     -                                                   
    SP4:                                -     -     -           -     -     -     -           -     -     -                                                         
    SP5:                                -     -     -           -     -     -     -     -     -     -     -     -                                                   

    ExUns: 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23
    SP1:                                            -                       -               
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MED15

    Expression
    for MED15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGGAGCGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MED15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED15

    SOURCE GeneReport for Unigene cluster: Hs.517421

    UniProtKB/Swiss-Prot: MED15_HUMAN, Q96RN5
    Tissue specificity: Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood
    leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and
    peripheral blood and lowest in the pancreas and kidney

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    Orthologs
    for MED15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MED15 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Med151 , 5 mediator complex subunit 151, 5 87.84(n)1
    92.91(a)1    		   16 (10.94 cM)5
    941121  NM_033609.21  NP_291087.21 
     176512215 
    chicken
    (Gallus gallus)    		 Aves MED151 mediator complex subunit 15 73.49(n)
    79.01(a)    		   416941  XM_415235.3  XP_415235.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia ARC1052 ARC105 protein 74.85(n)    AF378334.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.74972 Danio rerio mRNA similar to PC2 (positive cofactor more 76.75(n)    BC045472.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MED151 Mediator complex subunit 15 47.95(n)
    38.56(a)    		   33223  NM_134684.2  NP_608528.1 


    ENSEMBL Gene Tree for MED15 (if available)
    TreeFam Gene Tree for MED15 (if available) 

    Paralogs
    for MED15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED15 gene
    18/37 SIMAP similar genes for MED15 using alignment to 19 protein entries:     MED15_HUMAN (see all proteins) (see all similar genes):
    DKFZp762B1216    DKFZp686A2214    UTY    ZNF74    NEK4    SHANK2
    ATP6V0A1    FAM175A    HECW1    KLHL2    NPLOC4    TNFRSF17
    APOD    CATSPERG    CFLAR    FAM210A    EIF3L    PLA2G6

    MED15 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for MED15 (see all 8)
    PGOHUM00000250102 PGOHUM00000248026 PGOHUM00000250332 PGOHUM00000250446 PGOHUM00000240325


    Genomic Variants
    for MED15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MED15_HUMAN, Q96RN5
    Polymorphism: The poly-Gln region from amino acids 235-262 of PCQAP is polymorphic. There are from 15 to 18 repeats in
    the Italian population


    10/1549 NCBI SNPs in MED15 are shown (see all 1549)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1910673171,2
    		--20859903(+) CTCACG/TCCTGT 2 -- us2k10--------
    rs790294471,2
    		C--20859981(+) AACACA/GGTGAA 2 -- us2k10--------
    rs795381791,2
    		C,--20859989(+) GAAACA/CCTGTC 2 -- us2k10--------
    rs2015900511,2
    		--20860364(+) ACCTG-/TTAATC 2 -- us2k10--------
    rs18075111,2
    		C,F,H,--20860379(+) CTACTC/TGGGAG 2 -- us2k17Minor allele frequency- T:0.15NA WA CSA 13
    rs1445885181,2
    		--20860473(+) CAGGGC/TGAGAC 2 -- us2k10--------
    rs1120979361,2
    		C,--20860487(+) ATCTC-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1831870021,2
    		--20860661(+) TGGGGC/TACGCT 2 -- us2k10--------
    rs1884935301,2
    		--20860742(+) GCCGAC/GATGGC 2 -- us2k10--------
    rs1930540041,2
    		--20860746(+) AGATGG/TCACCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MED15 (20850200 - 20941919 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for MED15
         7 CNVs: 59056 67838 35984 35985 31071 35983 5169

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    Disorders / Diseases
    for MED15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MED15 for disorders           About GeneDecksing

    OMIM gene information: 607372    OMIM disorders: --

    11 diseases for MED15:    About MalaCards
    digeorge syndrome    epicondylitis    velocardiofacial syndrome    endometrial cancer
    nasopharyngitis    prostate cancer    ataxia    cholesterol
    prostatitis    schizophrenia    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for MED15:
    Epicondylitis     Velocardiofacial syndrome
    Human Genome Epidemiology (HuGE) Navigator: MED15 (3 documents)

    Export disorders for MED15 gene to outside databases

    Publications
    for MED15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED15 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with MED15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. (PubMed id 11414760)1, 2, 3, 9 Berti L....Meisterernst M. (2001)
    2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S....Conaway R.C. (2004)
    3. A novel glutamine-rich putative transcriptional adaptor protein (TIG- 1), preferentially expressed in placental and bone-marrow tissues. (PubMed id 11024300)1, 2, 3 Abraham S. and Solomon W.B. (2000)
    4. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. (PubMed id 16799563)1, 2, 9 Yang F....Naeaer A.M. (2006)
    5. TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. (PubMed id 16904669)1, 2 Ishikawa H....Takahashi N. (2006)
    6. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    10. A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. (PubMed id 12167862)1, 2 Kato Y.... He X. (2002)

    External Searches for MED15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MED15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51586 HGNC: 14248 AceView: PCQAP Ensembl:ENSG00000099917 euGenes: HUgn51586
    ECgene: MED15 H-InvDB: MED15

    Other Databases showing MED15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MED15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED15 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MED15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MED15 gene:
    Search GeneIP for patents involving MED15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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