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Aliases for MED14 Gene

Aliases for MED14 Gene

  • Mediator Complex Subunit 14 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 170 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 150 KDa Component 3 4
  • Activator-Recruited Cofactor 150 KDa Component 3 4
  • CRSP Complex Subunit 2 3 4
  • RGR1 Homolog 3 4
  • DRIP150 3 4
  • TRAP170 3 4
  • CXorf4 3 4
  • ARC150 3 4
  • CRSP2 3 4
  • EXLM1 3 4
  • HRGR1 3 4
  • RGR1 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 2, 150kDa 2
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 2 (150kD) 3
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP170 3
  • Vitamin D Receptor-Interacting Protein Complex Component DRIP150 3
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 2 4
  • Transcriptional Co-Activator CRSP150 3
  • Transcriptional Coactivator CRSP150 4
  • Human Homolog Of Yeast RGR1 3
  • CRSP150 3
  • CSRP 3

External Ids for MED14 Gene

Previous HGNC Symbols for MED14 Gene

  • CXorf4
  • CRSP2

Previous GeneCards Identifiers for MED14 Gene

  • GC0XM040393
  • GC0XM040507
  • GC0XM038238

Summaries for MED14 Gene

Entrez Gene Summary for MED14 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED14 Gene

MED14 (Mediator Complex Subunit 14) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Thyroid hormone signaling pathway. GO annotations related to this gene include receptor activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for MED14 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED14 Gene

Genomics for MED14 Gene

Regulatory Elements for MED14 Gene

Enhancers for MED14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MED14 on UCSC Golden Path with GeneCards custom track

Promoters for MED14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED14 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED14 Gene

Chromosome:
X
Start:
40,648,306 bp from pter
End:
40,736,122 bp from pter
Size:
87,817 bases
Orientation:
Minus strand

Genomic View for MED14 Gene

Genes around MED14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED14 Gene

Proteins for MED14 Gene

  • Protein details for MED14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60244-MED14_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 14
    Protein Accession:
    O60244
    Secondary Accessions:
    • Q4KMR7
    • Q9UNB3

    Protein attributes for MED14 Gene

    Size:
    1454 amino acids
    Molecular mass:
    160607 Da
    Quaternary structure:
    • Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2.

neXtProt entry for MED14 Gene

Proteomics data for MED14 Gene at MOPED

Post-translational modifications for MED14 Gene

  • Ubiquitination at Lys 185, Lys 188, Lys 399, Lys 510, Lys 699, Lys 1256, and Lys 1295
  • Modification sites at PhosphoSitePlus

Other Protein References for MED14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED14 Gene

Domains & Families for MED14 Gene

Gene Families for MED14 Gene

Protein Domains for MED14 Gene

Suggested Antigen Peptide Sequences for MED14 Gene

Graphical View of Domain Structure for InterPro Entry

O60244

UniProtKB/Swiss-Prot:

MED14_HUMAN :
  • Belongs to the Mediator complex subunit 14 family.
Family:
  • Belongs to the Mediator complex subunit 14 family.
genes like me logo Genes that share domains with MED14: view

Function for MED14 Gene

Molecular function for MED14 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0004872 receptor activity IDA 12218053
genes like me logo Genes that share ontologies with MED14: view
genes like me logo Genes that share phenotypes with MED14: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED14 Gene

Localization for MED14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED14 Gene COMPARTMENTS Subcellular localization image for MED14 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IEA,IDA 10198638
genes like me logo Genes that share ontologies with MED14: view

Pathways & Interactions for MED14 Gene

genes like me logo Genes that share pathways with MED14: view

Pathways by source for MED14 Gene

Gene Ontology (GO) - Biological Process for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0019827 stem cell population maintenance IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12037571
genes like me logo Genes that share ontologies with MED14: view

No data available for SIGNOR curated interactions for MED14 Gene

Drugs & Compounds for MED14 Gene

(2) Drugs for MED14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MED14: view

Transcripts for MED14 Gene

Unigene Clusters for MED14 Gene

Mediator complex subunit 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED14 Gene

No ASD Table

Relevant External Links for MED14 Gene

GeneLoc Exon Structure for
MED14
ECgene alternative splicing isoforms for
MED14

Expression for MED14 Gene

mRNA expression in normal human tissues for MED14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED14 Gene

This gene is overexpressed in Spleen (25.9), Lymph node (11.3), Placenta (7.4), and Plasma (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED14 Gene



SOURCE GeneReport for Unigene cluster for MED14 Gene Hs.407604

mRNA Expression by UniProt/SwissProt for MED14 Gene

O60244-MED14_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MED14: view

Protein tissue co-expression partners for MED14 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for MED14 Gene

Orthologs for MED14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MED14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED14 35
  • 93.78 (n)
  • 97.52 (a)
MED14 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED14 35
  • 93.72 (n)
  • 98.62 (a)
MED14 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med14 35
  • 90.41 (n)
  • 96.21 (a)
Med14 16
Med14 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED14 35
  • 99.59 (n)
  • 99.79 (a)
MED14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med14 35
  • 90.89 (n)
  • 96.42 (a)
oppossum
(Monodelphis domestica)
Mammalia MED14 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED14 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED14 35
  • 81.85 (n)
  • 91.1 (a)
MED14 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED14 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med14 35
  • 76.72 (n)
  • 86.89 (a)
Str.8704 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5858 35
zebrafish
(Danio rerio)
Actinopterygii Dr.8754 35
med14 35
  • 72.42 (n)
  • 81.3 (a)
med14 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED14_ANOGA 35
  • 47.62 (n)
  • 42.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED14 35
  • 48.56 (n)
  • 42.34 (a)
MED14 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rgr-1 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGR1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2652 36
  • 39 (a)
OneToOne
Species with no ortholog for MED14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED14 Gene

ENSEMBL:
Gene Tree for MED14 (if available)
TreeFam:
Gene Tree for MED14 (if available)

Paralogs for MED14 Gene

No data available for Paralogs for MED14 Gene

Variants for MED14 Gene

Sequence variations from dbSNP and Humsavar for MED14 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036608 A breast cancer sample
rs747684159 -- 40,665,241(+) AAGAC(C/T)GGCTA intron-variant
rs747701911 -- 40,671,987(+) AGAAA(A/G)TTAAA intron-variant
rs747724760 -- 40,673,835(+) GAGCG(-/AA)ACTCC intron-variant
rs747753699 -- 40,687,328(+) GTACC(C/T)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED14 Gene

Variant ID Type Subtype PubMed ID
esv33829 CNV Loss 17666407
nsv518965 CNV Gain 19592680
nsv525223 CNV Gain 19592680

Variation tolerance for MED14 Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MED14 Gene

Disorders for MED14 Gene

Relevant External Links for MED14

Genetic Association Database (GAD)
MED14
Human Genome Epidemiology (HuGE) Navigator
MED14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED14

No disorders were found for MED14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED14 Gene

Publications for MED14 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4 67
  2. Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). (PMID: 17306756) Lee J. … Safe S. (Arch. Biochem. Biophys. 2007) 3 23
  3. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. (PMID: 15625066) Lee J.E. … Safe S. (J. Biol. Chem. 2005) 3 23
  4. Role of metazoan mediator proteins in interferon-responsive transcription. (PMID: 12509459) Lau J.F. … Horvath C.M. (Mol. Cell. Biol. 2003) 3 23
  5. Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4. (PMID: 12825353) Demirci F.Y. … Gorin M.B. (DNA Seq. 2003) 3 23

Products for MED14 Gene

Sources for MED14 Gene

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