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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED14 Gene

protein-coding   GIFtS: 60
GCID: GC0XM040507

Mediator Complex Subunit 14

(Previous names: cofactor required for Sp1 transcriptional activation, subunit...)
(Previous symbols: CXorf4, CRSP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mediator Complex Subunit 141 2 3     RGR1 Homolog2 3
CRSP21 2 3 5     Cofactor Required For Sp1 Transcriptional Activation, Subunit 2, 150kDa1
CXorf41 2 3 5     CRSP1502
EXLM12 3 5     CSRP2
TRAP1702 3 5     Cofactor Required For Sp1 Transcriptional Activation, Subunit 2 (150kD)2
Activator-Recruited Cofactor 150 KDa Component2 3     Human Homolog Of Yeast RGR12
Thyroid Hormone Receptor-Associated Protein Complex 170 KDa Component2 3     Mediator Of RNA Polymerase II Transcription Subunit 142
Vitamin D3 Receptor-Interacting Protein Complex 150 KDa Component2 3     Thyroid Hormone Receptor-Associated Protein Complex Component TRAP1702
ARC1502 3     Transcriptional Co-Activator CRSP1502
DRIP1502 3     Vitamin D Receptor-Interacting Protein Complex Component DRIP1502
RGR12 3     Trap1703
CRSP Complex Subunit 22 3     Cofactor Required For Sp1 Transcriptional Activation Subunit 23
hRGR12 3     Transcriptional Coactivator CRSP1503

External Ids:    HGNC: 23701   Entrez Gene: 92822   Ensembl: ENSG000001801827   OMIM: 3001825   UniProtKB: O602443   

Export aliases for MED14 gene to outside databases

Previous GC identifers: GC0XM040393 GC0XM038238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MED14 Gene:
The activation of gene transcription is a multistep process that is triggered by factors that recognize
transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation
by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required
for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein
is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which
interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and
cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome
X-inactivation. (provided by RefSeq, Jul 2008)

GeneCards Summary for MED14 Gene: 
MED14 (mediator complex subunit 14) is a protein-coding gene. Diseases associated with MED14 include conjunctivitis, and thyroiditis, and among its related super-pathways are Gene Expression and Axon guidance. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity.

UniProtKB/Swiss-Prot: MED14_HUMAN, O60244
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED14 gene promoter:
         ISGF-3   Tal-1   MyoD   FOXD3   Tal-1beta   LCR-F1   E47   HOXA5   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED14 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11.4

MED14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED14 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM040507:  view genomic region     (about GC identifiers)

Start:
40,507,558 bp from pter      End:
40,595,110 bp from pter
Size:
87,553 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MED14_HUMAN, O60244 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 14  
Size: 1454 amino acids; 160607 Da
Subunit: Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4,
MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20,
MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12,
MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module
is less active than Mediator lacking this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP,
DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2
Subcellular location: Nucleus (Probable)
Secondary accessions: Q4KMR7 Q9UNB3

Explore the universe of human proteins at neXtProt for MED14: NX_O60244

Explore proteomics data for MED14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60244

  • MED14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MED14 Protein Expression
    REFSEQ proteins: NP_004220.2  
    ENSEMBL proteins: 
     ENSP00000323720   ENSP00000392586   ENSP00000411357  
    Reactome Protein details: O60244
    Human Recombinant Protein Products for MED14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MED14
    GenScript Custom Purified and Recombinant Proteins Services for MED14
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED14 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10235267
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA10198638

    MED14 for ontologies           About GeneDecksing



    MED14 Antibody Products: 
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    Novus Biologicals MED14 Antibody
    Abcam antibodies for MED14
    Cloud-Clone Corp. Antibodies for MED14 
    Search ThermoFisher Antibodies for MED14
    LSBio Antibodies in human, mouse, rat for MED14 

    Assay Products for MED14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED14 
    Cloud-Clone Corp. CLIAs for MED14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013947 Mediator_Med14

    Graphical View of Domain Structure for InterPro Entry O60244

    ProtoNet protein and cluster: O60244

    1 Blocks protein domain: IPB013947 Mediator complex

    UniProtKB/Swiss-Prot: MED14_HUMAN, O60244
    Similarity: Belongs to the Mediator complex subunit 14 family


    MED14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED14_HUMAN, O60244
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003712transcription cofactor activity IDA12218053
    GO:0003713transcription coactivator activity IDA12037571
    GO:0004872receptor activity IDA12218053
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity NAS10235266
         
    MED14 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for MED14:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased influenza A/WSN/33 r 
     Decreased p24 protein expressi  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content, incr 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Med14):
     normal 

    MED14 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MED14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MED14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED14
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate MED14 (see all 58):
    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-4328 hsa-miR-300 hsa-miR-4272 hsa-miR-128 hsa-miR-16-1* hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidMED14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED14
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MED14

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MED14 (see all 6)
    OriGene ORF clones in mouse, rat for MED14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED14 (NM_004229)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED14
    Sirion Biotech Customized lentivirus for stable overexpression of MED14 
                         Customized lentivirus expression plasmids for stable overexpression of MED14 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MED14
    Search LifeMap BioReagents cell lines for MED14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MED14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Axon guidance
    Developmental Biology0.69
    3Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MED14
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED14
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED14
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MED14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/115 Interacting proteins for MED14 (O602441, 2, 3 ENSP000003237204) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-394489,EBI-375543 MINT-8110167 I2D: score=3 STRING: ENSP00000361423
    FYNP062411, 2, 3, ENSP000003576564EBI-394489,EBI-515315 MINT-8111067 I2D: score=3 STRING: ENSP00000357656
    MED1Q156482, 3, ENSP000003006514MINT-6744331 MINT-6744763 I2D: score=2 STRING: ENSP00000300651
    CDK8P493362, 3, ENSP000003709384MINT-6744763 I2D: score=1 STRING: ENSP00000370938
    MED15Q96RN52, 3, ENSP000002632054MINT-6744763 I2D: score=1 STRING: ENSP00000263205
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9989412
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--
    GO:0030518intracellular steroid hormone receptor signaling pathway IDA11867769

    MED14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MED14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED14

    2 Novoseek inferred chemical compound relationships for MED14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 43.9 3 17306756 (2), 15625066 (1)
    estrogen 28.3 6 15625066 (3), 17306756 (2)

    Search CenterWatch for drugs/clinical trials and news about MED14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MED14 gene: 
    NM_004229.3  

    Unigene Cluster for MED14:

    Mediator complex subunit 14
    Hs.407604  [show with all ESTs]
    Unigene Representative Sequence: AB006651
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324817(uc004dex.4 uc010nhe.1) ENST00000416199 ENST00000433003(uc004dey.1)
    ENST00000472736 ENST00000496531 ENST00000482034 ENST00000492219 ENST00000495865
    ENST00000463072
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED14
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate MED14 (see all 58):
    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-4328 hsa-miR-300 hsa-miR-4272 hsa-miR-128 hsa-miR-16-1* hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidMED14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MED14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED14
    Clone
    Products:
         
    OriGene clones in human, mouse for MED14 (see all 6)
    OriGene ORF clones in mouse, rat for MED14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED14 (NM_004229)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED14
    Sirion Biotech Customized lentivirus for stable overexpression of MED14 
                         Customized lentivirus expression plasmids for stable overexpression of MED14 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MED14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED14

    Additional mRNA sequence: 

    AB006651.1 AF070563.1 AF104256.1 AF135802.1 AF304448.1 AJ012077.1 AK293070.1 AK308871.1 
    BC098377.1 BC132672.1 BC132674.1 BC144231.1 

    15 DOTS entries:

    DT.416891  DT.207422  DT.101964852  DT.91758292  DT.100773919  DT.99934405  DT.100725407  DT.121289920 
    DT.121289945  DT.40263154  DT.75114850  DT.91683768  DT.96086380  DT.97813479  DT.86846470 

    24/265 AceView cDNA sequences (see all 265):

    F22189 AF070563 AI263090 Z41980 AW963669 AI168429 AA370877 AW386473 
    BM742336 BM472453 Z38262 BF594795 AA737180 AA370835 AI828983 AB006651 
    CA430810 BM784815 AF104256 AI718098 BM765536 CA394270 AA460857 AA857946 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED14 expression in normal human tissues (normalized intensities)      MED14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTTCTG
    MED14 Expression
    About this image


    MED14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             brain/midbrain   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             bone marrow cd34+   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon

    See MED14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED14

    SOURCE GeneReport for Unigene cluster: Hs.407604

    UniProtKB/Swiss-Prot: MED14_HUMAN, O60244
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including MED14: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MED14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MED14 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med141 , 5 mediator complex subunit 141, 5 90.87(n)1
    96.9(a)1
      X (7.52 cM)5
    268961  NM_001048208.11  NP_001041673.11 
     126753695 
    chicken
    (Gallus gallus)
    Aves MED141 mediator complex subunit 14 81.92(n)
    91.05(a)
      418572  XM_416776.2  XP_416776.2 
    lizard
    (Anolis carolinensis)
    Reptilia MED146
    Uncharacterized protein
    89(a)
    1 ↔ 1
    3(133851892-133898983)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58582 Xenopus laevis transcribed sequence with moderate similarity more 79.52(n)    CA971285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.87542 Danio rerio mRNA similar to cofactor required for Sp1 more 78.26(n)    BC045931.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED141 Mediator complex subunit 14 48.9(n)
    42.59(a)
      38073  NM_138197.2  NP_612041.2 
    worm
    (Caenorhabditis elegans)
    Secernentea rgr-16
    Mediator of RNA polymerase II transcription subuni...
    21(a)
    1 ↔ 1
    III(9393479-9404532)


    ENSEMBL Gene Tree for MED14 (if available)
    TreeFam Gene Tree for MED14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1114 SNPs in MED14 are shown (see all 1114)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0366084
    A breast cancer sample4--see VAR_0366082 F L mis40--------
    rs70536461,2
    C,H--40424883(+) CACAGT/GTATTA 1 -- ds50016Minor allele frequency- G:0.00NS EA NA 420
    rs1848051571,2
    --40425438(+) TTCAAA/CTTCAT 1 -- ut310--------
    rs1880978041,2
    --40425481(+) TTTGCA/GCACTG 1 -- ut310--------
    rs115496991,2
    C--40425569(-) TACACA/TTGATG 1 -- ut31 ese30--------
    rs1810010961,2
    --40425587(+) AATTAA/GCATTT 1 -- ut310--------
    rs736249181,2
    C--40425631(+) GTTAAT/CTCTTA 1 -- ut311Minor allele frequency- C:0.00WA 2
    rs1848757541,2
    --40425698(+) CATGTA/GGATTT 1 -- ut310--------
    rs1893836841,2
    --40425782(+) CTGATA/GTGATT 1 -- ut310--------
    rs1813998111,2
    --40425880(+) GAGTTC/GGGTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MED14 (40507558 - 40595110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MED14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33829CNV Loss17666407
    nsv518965CNV Gain19592680
    nsv525223CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): MED14
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MED14
    DNA2.0 Custom Variant and Variant Library Synthesis for MED14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300182    OMIM disorders: --

    3 diseases for MED14:    About MalaCards
    conjunctivitis    thyroiditis    breast cancer


    MED14 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MED14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 17.7 4 15625066 (2), 17306756 (2)

    Genetic Association Database (GAD): MED14
    Human Genome Epidemiology (HuGE) Navigator: MED14 (1 document)

    Export disorders for MED14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED14 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with MED14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PubMed id 9989412)1, 2, 3 Ryu S.... Tjian R. (1999)
    2. Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method. (PubMed id 9598311)1, 2, 3 Yoshikawa H....Matsubara K. (1998)
    3. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. (PubMed id 15625066)1, 2, 9 Lee J.E.... Safe S. (2005)
    4. Role of metazoan mediator proteins in interferon-responsive transcription. (PubMed id 12509459)1, 2, 9 Lau J.F.... Horvath C.M. (2003)
    5. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PubMed id 12218053)1, 2, 9 Wang Q.... Fondell J.D. (2002)
    6. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    7. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    8. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. (PubMed id 11867769)1, 2 Kang Y.K.... Roeder R.G. (2002)
    9. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2 Rachez C.... Freedman L.P. (1999)
    10. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9282 HGNC: 2370 AceView: CRSP2 Ensembl:ENSG00000180182 euGenes: HUgn9282
    ECgene: MED14 H-InvDB: MED14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MED14 gene:
    Search GeneIP for patents involving MED14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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