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Aliases for MED14 Gene

Aliases for MED14 Gene

  • Mediator Complex Subunit 14 2 3 4
  • TRAP170 3 4 6
  • CXorf4 3 4 6
  • CRSP2 3 4 6
  • EXLM1 3 4 6
  • Thyroid Hormone Receptor-Associated Protein Complex 170 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 150 KDa Component 3 4
  • Activator-Recruited Cofactor 150 KDa Component 3 4
  • CRSP Complex Subunit 2 3 4
  • RGR1 Homolog 3 4
  • DRIP150 3 4
  • ARC150 3 4
  • HRGR1 3 4
  • RGR1 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 2, 150kDa 2
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 2 (150kD) 3
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP170 3
  • Vitamin D Receptor-Interacting Protein Complex Component DRIP150 3
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 2 4
  • Mediator Of RNA Polymerase II Transcription Subunit 14 3
  • Transcriptional Co-Activator CRSP150 3
  • Transcriptional Coactivator CRSP150 4
  • Human Homolog Of Yeast RGR1 3
  • CRSP150 3
  • CSRP 3

External Ids for MED14 Gene

Previous HGNC Symbols for MED14 Gene

  • CXorf4
  • CRSP2

Previous GeneCards Identifiers for MED14 Gene

  • GC0XM040393
  • GC0XM040507
  • GC0XM038238

Summaries for MED14 Gene

Entrez Gene Summary for MED14 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED14 Gene

MED14 (Mediator Complex Subunit 14) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for MED14 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED14 Gene

Genomics for MED14 Gene

Regulatory Elements for MED14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED14 Gene

Start:
40,648,306 bp from pter
End:
40,736,122 bp from pter
Size:
87,817 bases
Orientation:
Minus strand

Genomic View for MED14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED14 Gene

Proteins for MED14 Gene

  • Protein details for MED14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60244-MED14_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 14
    Protein Accession:
    O60244
    Secondary Accessions:
    • Q4KMR7
    • Q9UNB3

    Protein attributes for MED14 Gene

    Size:
    1454 amino acids
    Molecular mass:
    160607 Da
    Quaternary structure:
    • Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2.

neXtProt entry for MED14 Gene

Proteomics data for MED14 Gene at MOPED

Post-translational modifications for MED14 Gene

  • Ubiquitination at Lys185, Lys188, Lys399, Lys510, Lys699, Lys1256, and Lys1295
  • Modification sites at PhosphoSitePlus

Other Protein References for MED14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED14 Gene

Domains for MED14 Gene

Protein Domains for MED14 Gene

Suggested Antigen Peptide Sequences for MED14 Gene

Graphical View of Domain Structure for InterPro Entry

O60244

UniProtKB/Swiss-Prot:

MED14_HUMAN :
  • O60244
Family:
  • Belongs to the Mediator complex subunit 14 family.
genes like me logo Genes that share domains with MED14: view

No data available for Gene Families for MED14 Gene

Function for MED14 Gene

Molecular function for MED14 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IDA 12037571
GO:0004872 receptor activity IDA 12218053
GO:0005515 protein binding IPI 24882805
genes like me logo Genes that share ontologies with MED14: view
genes like me logo Genes that share phenotypes with MED14: view

Animal Model Products

CRISPR Products

miRNA for MED14 Gene

miRTarBase miRNAs that target MED14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED14 Gene

Localization for MED14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED14 Gene COMPARTMENTS Subcellular localization image for MED14 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IDA 10198638
genes like me logo Genes that share ontologies with MED14: view

Pathways for MED14 Gene

genes like me logo Genes that share pathways with MED14: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9989412
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0019827 stem cell maintenance IEA --
GO:0030518 intracellular steroid hormone receptor signaling pathway IDA 11867769
genes like me logo Genes that share ontologies with MED14: view

Compounds for MED14 Gene

(2) Novoseek inferred chemical compound relationships for MED14 Gene

Compound -log(P) Hits PubMed IDs
vitamin d 43.9 3
estrogen 28.3 5
genes like me logo Genes that share compounds with MED14: view

Transcripts for MED14 Gene

Unigene Clusters for MED14 Gene

Mediator complex subunit 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED14

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MED14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED14 Gene

No ASD Table

Relevant External Links for MED14 Gene

GeneLoc Exon Structure for
MED14
ECgene alternative splicing isoforms for
MED14

Expression for MED14 Gene

mRNA expression in normal human tissues for MED14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED14 Gene

SOURCE GeneReport for Unigene cluster for MED14 Gene Hs.407604

mRNA Expression by UniProt/SwissProt for MED14 Gene

O60244-MED14_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with MED14: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MED14 Gene

Orthologs for MED14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MED14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED14 35
  • 99.59 (n)
  • 99.79 (a)
MED14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED14 35
  • 93.78 (n)
  • 97.52 (a)
MED14 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED14 35
  • 93.72 (n)
  • 98.62 (a)
MED14 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med14 35
  • 90.41 (n)
  • 96.21 (a)
Med14 16
Med14 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED14 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED14 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med14 35
  • 90.89 (n)
  • 96.42 (a)
chicken
(Gallus gallus)
Aves MED14 35
  • 81.85 (n)
  • 91.1 (a)
MED14 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED14 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5858 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med14 35
  • 76.72 (n)
  • 86.89 (a)
Str.8704 35
zebrafish
(Danio rerio)
Actinopterygii Dr.8754 35
med14 35
  • 72.42 (n)
  • 81.3 (a)
med14 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED14_ANOGA 35
  • 47.62 (n)
  • 42.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED14 35
  • 48.56 (n)
  • 42.34 (a)
MED14 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rgr-1 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGR1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2652 36
  • 39 (a)
OneToOne
Species with no ortholog for MED14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED14 Gene

ENSEMBL:
Gene Tree for MED14 (if available)
TreeFam:
Gene Tree for MED14 (if available)

Paralogs for MED14 Gene

No data available for Paralogs for MED14 Gene

Variants for MED14 Gene

Sequence variations from dbSNP and Humsavar for MED14 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1128513 -- 40,651,521(-) AAAGT(C/T)ATGAA utr-variant-3-prime, intron-variant
rs3923680 -- 40,652,550(-) GGAAG(C/T)TGACC intron-variant
rs4827041 -- 40,685,573(+) CTGCA(C/G)ATGAC intron-variant
rs4827042 -- 40,704,878(+) ttaat(A/G)aagca intron-variant
rs4827043 -- 40,723,759(+) cttca(C/T)taaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED14 Gene

Variant ID Type Subtype PubMed ID
esv33829 CNV Loss 17666407
nsv518965 CNV Gain 19592680
nsv525223 CNV Gain 19592680

Relevant External Links for MED14 Gene

HapMap Linkage Disequilibrium report
MED14
Locus Specific Mutation Databases (LSDB)
MED14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED14 Gene

Disorders for MED14 Gene

(1) Novoseek inferred disease relationships for MED14 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 17.7 4

Relevant External Links for MED14

Genetic Association Database (GAD)
MED14
Human Genome Epidemiology (HuGE) Navigator
MED14
genes like me logo Genes that share disorders with MED14: view

No data available for UniProtKB/Swiss-Prot for MED14 Gene

Publications for MED14 Gene

  1. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. (PMID: 15625066) Lee J.E. … Safe S. (J. Biol. Chem. 2005) 3 4 23
  2. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PMID: 12218053) Wang Q. … Fondell J.D. (J. Biol. Chem. 2002) 3 4 23
  3. Role of metazoan mediator proteins in interferon-responsive transcription. (PMID: 12509459) Lau J.F. … Horvath C.M. (Mol. Cell. Biol. 2003) 3 4 23
  4. Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method. (PMID: 9598311) Yoshikawa H. … Matsubara K. (Genomics 1998) 2 3 4
  5. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4

Products for MED14 Gene

Sources for MED14 Gene

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