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Aliases for MED14 Gene

Aliases for MED14 Gene

  • Mediator Complex Subunit 14 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 170 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex 150 KDa Component 3 4
  • Activator-Recruited Cofactor 150 KDa Component 3 4
  • CRSP Complex Subunit 2 3 4
  • RGR1 Homolog 3 4
  • DRIP150 3 4
  • TRAP170 3 4
  • CXorf4 3 4
  • ARC150 3 4
  • CRSP2 3 4
  • EXLM1 3 4
  • HRGR1 3 4
  • RGR1 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 2, 150kDa 2
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 2 (150kD) 3
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP170 3
  • Vitamin D Receptor-Interacting Protein Complex Component DRIP150 3
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 2 4
  • Mediator Of RNA Polymerase II Transcription Subunit 14 3
  • Transcriptional Co-Activator CRSP150 3
  • Transcriptional Coactivator CRSP150 4
  • Human Homolog Of Yeast RGR1 3
  • CRSP150 3
  • CSRP 3

External Ids for MED14 Gene

Previous HGNC Symbols for MED14 Gene

  • CXorf4
  • CRSP2

Previous GeneCards Identifiers for MED14 Gene

  • GC0XM040393
  • GC0XM040507
  • GC0XM038238

Summaries for MED14 Gene

Entrez Gene Summary for MED14 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED14 Gene

MED14 (Mediator Complex Subunit 14) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include receptor activity and transcription cofactor activity.

UniProtKB/Swiss-Prot for MED14 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED14 Gene

Genomics for MED14 Gene

Regulatory Elements for MED14 Gene

Enhancers for MED14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF040577 1.3 Ensembl ENCODE 22.6 +156.1 156054 4.8 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 FOS ZNF263 CEBPZ SP3 DDX3X CASK-AS1 USP9X MED14 ATP6AP2 GC0XM040583
GH0XF041083 1.6 FANTOM5 ENCODE 13.7 -350.4 -350402 6.1 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CASK-AS1 LOC100132831 MPC1L IMPDH1P2 ENSG00000233103 DDX3X USP9X MED14 CXorf38 GC0XP041123
GH0XF041329 1.6 FANTOM5 ENCODE 13.5 -597.4 -597352 7.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 DMAP1 DDX3X CASK-AS1 CXorf38 USP9X MED14 NYX PIR48586
GH0XF039893 1.3 Ensembl ENCODE 14.5 +839.8 839785 4.9 ATF1 PKNOX1 ZFP64 FEZF1 YY1 ZNF121 GLIS2 GATA2 FOS DEK MED14 BCOR PIR53061 RPS11P7
GH0XF041441 1.3 Ensembl ENCODE 14 -706.7 -706679 2.4 PKNOX1 MLX ARID4B DMAP1 ZNF2 YY1 ZNF143 FOS KLF13 ZNF263 DDX3X MED14 CASK-AS1 NYX PIR52979
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED14 on UCSC Golden Path with GeneCards custom track

Promoters for MED14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001489526 822 3800 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3

Genomic Location for MED14 Gene

Chromosome:
X
Start:
40,648,306 bp from pter
End:
40,736,122 bp from pter
Size:
87,817 bases
Orientation:
Minus strand

Genomic View for MED14 Gene

Genes around MED14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED14 Gene

Proteins for MED14 Gene

  • Protein details for MED14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60244-MED14_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 14
    Protein Accession:
    O60244
    Secondary Accessions:
    • Q4KMR7
    • Q9UNB3

    Protein attributes for MED14 Gene

    Size:
    1454 amino acids
    Molecular mass:
    160607 Da
    Quaternary structure:
    • Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2.

neXtProt entry for MED14 Gene

Post-translational modifications for MED14 Gene

  • Ubiquitination at Lys 185, Lys 188, Lys 399, Lys 510, Lys 699, Lys 1256, and Lys 1295
  • Modification sites at PhosphoSitePlus

Other Protein References for MED14 Gene

No data available for DME Specific Peptides for MED14 Gene

Domains & Families for MED14 Gene

Gene Families for MED14 Gene

Protein Domains for MED14 Gene

Suggested Antigen Peptide Sequences for MED14 Gene

Graphical View of Domain Structure for InterPro Entry

O60244

UniProtKB/Swiss-Prot:

MED14_HUMAN :
  • Belongs to the Mediator complex subunit 14 family.
Family:
  • Belongs to the Mediator complex subunit 14 family.
genes like me logo Genes that share domains with MED14: view

Function for MED14 Gene

Molecular function for MED14 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IDA 12037571
GO:0004872 receptor activity IDA 12218053
GO:0005515 protein binding IPI 24882805
genes like me logo Genes that share ontologies with MED14: view
genes like me logo Genes that share phenotypes with MED14: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED14 Gene

Localization for MED14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED14 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IEA,IDA 10198638
GO:0070847 core mediator complex IBA --
genes like me logo Genes that share ontologies with MED14: view

Pathways & Interactions for MED14 Gene

genes like me logo Genes that share pathways with MED14: view

Pathways by source for MED14 Gene

Gene Ontology (GO) - Biological Process for MED14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,TAS 9989412
GO:0006367 transcription initiation from RNA polymerase II promoter IDA,TAS --
GO:0019827 stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with MED14: view

No data available for SIGNOR curated interactions for MED14 Gene

Drugs & Compounds for MED14 Gene

(2) Drugs for MED14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MED14: view

Transcripts for MED14 Gene

Unigene Clusters for MED14 Gene

Mediator complex subunit 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED14 Gene

No ASD Table

Relevant External Links for MED14 Gene

GeneLoc Exon Structure for
MED14
ECgene alternative splicing isoforms for
MED14

Expression for MED14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MED14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED14 Gene

This gene is overexpressed in Spleen (25.9), Lymph node (11.3), Placenta (7.4), and Plasma (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED14 Gene



Protein tissue co-expression partners for MED14 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED14 Gene:

MED14

SOURCE GeneReport for Unigene cluster for MED14 Gene:

Hs.407604

mRNA Expression by UniProt/SwissProt for MED14 Gene:

O60244-MED14_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MED14: view

Primer Products

No data available for mRNA differential expression in normal tissues for MED14 Gene

Orthologs for MED14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MED14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED14 34 35
  • 99.59 (n)
oppossum
(Monodelphis domestica)
Mammalia MED14 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED14 34 35
  • 93.78 (n)
dog
(Canis familiaris)
Mammalia MED14 34 35
  • 93.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED14 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med14 34
  • 90.89 (n)
mouse
(Mus musculus)
Mammalia Med14 34 16 35
  • 90.41 (n)
chicken
(Gallus gallus)
Aves MED14 34 35
  • 81.85 (n)
lizard
(Anolis carolinensis)
Reptilia MED14 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med14 34
  • 76.72 (n)
Str.8704 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5858 34
zebrafish
(Danio rerio)
Actinopterygii med14 34 35
  • 72.42 (n)
Dr.8754 34
fruit fly
(Drosophila melanogaster)
Insecta MED14 34 35
  • 48.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta MED14_ANOGA 34
  • 47.62 (n)
worm
(Caenorhabditis elegans)
Secernentea rgr-1 35
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGR1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2652 35
  • 39 (a)
OneToOne
Species where no ortholog for MED14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED14 Gene

ENSEMBL:
Gene Tree for MED14 (if available)
TreeFam:
Gene Tree for MED14 (if available)

Paralogs for MED14 Gene

No data available for Paralogs for MED14 Gene

Variants for MED14 Gene

Sequence variations from dbSNP and Humsavar for MED14 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036608 A breast cancer sample
rs10127014 -- 40,692,741(+) TTCCC(A/G)GTTTT reference, synonymous-codon
rs10543294 -- 40,710,701(+) CAAAC(-/TT)TTTAA intron-variant
rs10642445 -- 40,702,356(+) TTTTT(-/G)TTTTT intron-variant
rs111300514 -- 40,730,123(+) ACACA(C/T)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED14 Gene

Variant ID Type Subtype PubMed ID
esv33829 CNV loss 17666407
nsv1077225 CNV deletion 25765185
nsv518965 CNV gain 19592680
nsv525223 CNV gain 19592680

Variation tolerance for MED14 Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED14 Gene

Disorders for MED14 Gene

Relevant External Links for MED14

Genetic Association Database (GAD)
MED14
Human Genome Epidemiology (HuGE) Navigator
MED14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED14

No disorders were found for MED14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED14 Gene

Publications for MED14 Gene

  1. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. (PMID: 15625066) Lee J.E. … Safe S. (J. Biol. Chem. 2005) 3 4 22 64
  2. Role of metazoan mediator proteins in interferon-responsive transcription. (PMID: 12509459) Lau J.F. … Horvath C.M. (Mol. Cell. Biol. 2003) 3 4 22 64
  3. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PMID: 12218053) Wang Q. … Fondell J.D. (J. Biol. Chem. 2002) 3 4 22 64
  4. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4 64
  5. Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method. (PMID: 9598311) Yoshikawa H. … Matsubara K. (Genomics 1998) 2 3 4 64

Products for MED14 Gene

Sources for MED14 Gene

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