MED13 Gene
protein-coding GIFtS : 55 GCID: GC17 M060019
Mediator Complex Subunit 13 thyroid hormone receptor associated protein 1 )THRAP1 )
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Aliasesfor MED13 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Mediator Complex Subunit 13 1 2 3 DRIP2502 3 THRAP11 2 3 5 HSPC2212 TRAP2402 3 5 Mediator Of RNA Polymerase II Transcription Subunit 132 Thyroid Hormone Receptor Associated Protein 11 2 Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog2 Activator-Recruited Cofactor 250 KDa Component2 3 Thyroid Hormone Receptor-Associated Protein Complex Component TRAP2402 Thyroid Hormone Receptor-Associated Protein 12 3 Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit2 Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component2 3 KIAA05933 Vitamin D3 Receptor-Interacting Protein Complex Component DRIP2502 3 Trap2403 ARC2502 3
Export aliases for MED13 gene to outside databases Previous GC identifers: GC17M057374 GC17M055388
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Summariesfor MED13 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MED13 Gene: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. (provided by RefSeq, Jul 2008) GeneCards Summary for MED13 Gene: MED13 (mediator complex subunit 13) is a protein-coding gene. Diseases associated with MED13 include thyroiditis blindness related super-pathways are Gene Expression and Axon guidance . GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity . An important paralog of this gene is MED13L . UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7 Function : Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
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Genomic Viewsfor MED13 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NT_010783.15 NC_018928.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MED13 gene promoter:AML1a ATF-2 Lmo2 E47 Meis-1b CRE-BP1 Pax-3 Meis-1a RSRFC4 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for MED13 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q22-q23 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q22-q23 MED13 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M060019: view genomic region
(about GC identifiers )
Start: 60,019,966 bp from pter End:
60,142,643 bp from pter
Size: 122,678 bases Orientation:
minus strand
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Proteinsfor MED13 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7 See
protein sequence )Recommended Name: Size : 2174 amino acids; 239297 DaSubunit : Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location : NucleusSequence caution : Sequence=AAD22032.1; Type=Frameshift; Positions=Several;Secondary accessions : B2RU05 O60334Explore the universe of human proteins at neXtProt for MED13: NX_Q9UHV7 Explore proteomics data for MED13 at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q9UHV7 MED13 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_005112.2 ENSEMBL proteins: ENSP00000380888 ENSP00000464131 Reactome Protein details: Q9UHV7 Human Recombinant Protein Products for MED13: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing MED13 Antibody Products: Assay Products for MED13:
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Protein
Domains /for MED13 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 2 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry Q9UHV7 ProtoNet protein and cluster: Q9UHV7
UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7 Similarity : Belongs to the Mediator complex subunit 13 familyAbout GeneDecksing
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Functionfor MED13 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MED13_HUMAN, Q9UHV7 Function : Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for MED13 :5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Med13) :About GeneDecksing Animal Models: In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13
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Pathways & Interactionsfor MED13 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for MED13 About See pathways by source SuperPath Contained pathways About 1 Generic Transcription Pathway 2 Axon guidance 3 Transcription Ligand-Dependent Transcription of Retinoid-Target genes 4 Transcriptional Regulation of White Adipocyte Differentiation
Pathways by source See SuperPaths Show all pathways 1 1 4 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED13 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/112 Interacting proteins for MED13 (Q9UHV7 2 , 3 ENSP00000380888 4 via UniProtKB, MINT, STRING , and/or I2D (see all 112 )About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006357 regulation of transcription from RNA polymerase II promoter
-- -- GO:0006367 transcription initiation from RNA polymerase II promoter
TAS -- GO:0010467 gene expression
TAS -- GO:0030518 intracellular steroid hormone receptor signaling pathway
IDA 11867769 GO:0030521 androgen receptor signaling pathway
IDA 12218053
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Drugs & Compoundsfor MED13 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MED13 MED13
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Transcriptsfor MED13 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MED13 gene: NM_005121.2 Unigene Cluster for MED13:
Mediator complex subunit 13 Hs.282678 [show with all ESTs ] Unigene Representative Sequence: NM_005121 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000397786 (uc002izo.3 ) ENST00000582786 ENST00000583958 (uc002izp.3 )ENST00000581994 ENST00000578132 ENST00000580896 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB011165.2 AF117754.1 AF151055.1 AK054894.1 AK124099.1 BC044258.1 BC140891.1
12 DOTS entries : DT.452326 DT.100785751
DT.408817 DT.75144131 DT.100785756 DT.120956451 DT.91748799 DT.101977058 DT.86858782 DT.91748798 DT.91748811 DT.99953036 24/281 AceView cDNA sequences (see all 281 ):
BX477453 Z39732 AW450052 AI383948 AA434084 AA256007 BQ716876 AK124099 BQ879414 BX644531 AW075469 AA927599 AA255784 BI837972 AI954133 CA336432 BQ441612 AA480916 AI360826 AA665822 BQ709424 BC044258 R68630 AI433967 GeneLoc Exon Structure
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Expression for MED13 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MED13 expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: AAGCCTTCAAAbout this image
See MED13 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MED13 SOURCE GeneReport for Unigene cluster: Hs.282678 UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7 Tissue specificity : UbiquitousSABiosciences Expression via Pathway-Focused PCR Array including MED13 : Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13
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Orthologsfor MED13 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MED13 gene from 7/17 species (see all 17 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Med131 5
mediator complex subunit 131, 5
92(n) 1 93.83(a) 1
11 (51.75 cM) 5 327987 1 NM_001080931.1 1 NP_001074400.1 1 86267033 5
chicken Aves MED131
mediator complex subunit 13
82.07(n) 88.35(a)
417639 XM_415884.3 XP_415884.3
lizard Reptilia --MED136
Uncharacterized protein
79(a) 60(a)
1 ↔ many1 ↔ many
GL345053.1(785-9604) GL343470.1(14622-139110)
African clawed frog Amphibia Xl.105422
Xenopus laevis transcribed sequence with strong similarity more
88.84(n)
CA982815.1
zebrafish Actinopterygii Dr.136442
Transcribed sequence with moderate similarity to protein more
74.68(n)
CD594740.1
fruit fly Insecta skd6
skuld
23(a)
1 → many
3L(20985914-21020534)
worm Secernentea let-196
Mediator of RNA polymerase II transcription subuni... 14(a)
1 → many
II(8770975-8782021)
ENSEMBL Gene Tree for MED13 (if available)TreeFam Gene Tree for MED13 (if available)
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Paralogsfor MED13 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MED13 gene MED13L 2 1 SIMAP similar gene for MED13 using alignment to 2 protein entries: MED13_HUMAN (see all proteins ):MED13L About GeneDecksing 2 Pseudogenes.org Pseudogenes for MED13 PGOHUM00000235428 PGOHUM00000233965
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Genomic Variantsfor MED13 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MED13 (60019966 - 60142643 bp)
Structural Variations Database of Genomic Variants (DGV) 1 variation for MED13 : About this table Human Gene Mutation Database (HGMD) : MED13 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor MED13 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 603808
OMIM disorders : --2 : About MalaCards thyroiditis blindness Genetic Association Database (GAD): MED13 Human Genome Epidemiology (HuGE) Navigator: MED13 (3 documents) Export disorders for MED13 gene to outside databases
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Publicationsfor MED13 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MED13 gene, integrated from 9 sources (see all 51 ):(articles sorted by number of sources associating them with MED13) Utopia : connect your pdf to the dynamic
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 , 4(2010) The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683) 1 , 4(2009) MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967) 1 , 2 (2005) A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163) 1 , 2 (2004) Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PubMed id 10198638) 1 , 2 (1999) Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266) 1 , 2 (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267) 1 , 2 (1999) Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581) 1 , 2 (1998) A conserved Mediator-CDK8 kinase module association re gulates Mediator-RNA polymerase II interaction. (PubMed id 23563140) 1 (2013) The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13 L and regulates CDK8 module association with Mediator. (PubMed id 23322298) 1 (2013)
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External Searches for MED13 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MED13 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MED13 gene
(According to HUGE )
About This Section
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Specialized Databases showing MED13 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for MED13 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MED13 gene: MED13 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MED13 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MED13 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for MED13
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13
Search ThermoFisher Antibodies for MED13
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MED13
LSBio Antibodies in human mouse rat
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Aliases for MED13
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GeneGo (Thomson Reuters) Pathway for MED13
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