Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MED13 Gene

Aliases for MED13 Gene

  • Mediator Complex Subunit 13 2 3 4
  • TRAP240 3 4 6
  • THRAP1 3 4 6
  • Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex Component DRIP250 3 4
  • Activator-Recruited Cofactor 250 KDa Component 3 4
  • Thyroid Hormone Receptor Associated Protein 1 2 3
  • Thyroid Hormone Receptor-Associated Protein 1 3 4
  • DRIP250 3 4
  • ARC250 3 4
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP240 3
  • Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog 3
  • Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit 3
  • Mediator Of RNA Polymerase II Transcription Subunit 13 3
  • KIAA0593 4
  • HSPC221 3

External Ids for MED13 Gene

Previous Symbols for MED13 Gene

  • THRAP1

Summaries for MED13 Gene

Entrez Gene Summary for MED13 Gene

  • This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED13 Gene

MED13 (Mediator Complex Subunit 13) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity. An important paralog of this gene is MED13L.

UniProtKB/Swiss-Prot for MED13 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED13 Gene

Genomics for MED13 Gene

Genomic Location for MED13 Gene

Start:
61,942,605 bp from pter
End:
62,065,282 bp from pter
Size:
122,678 bases
Orientation:
Minus strand

Genomic View for MED13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED13 Gene

Regulatory Elements for MED13 Gene

Proteins for MED13 Gene

  • Protein details for MED13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV7-MED13_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 13
    Protein Accession:
    Q9UHV7
    Secondary Accessions:
    • B2RU05
    • O60334

    Protein attributes for MED13 Gene

    Size:
    2174 amino acids
    Molecular mass:
    239297 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAD22032.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MED13 Gene

Proteomics data for MED13 Gene at MOPED

Post-translational modifications for MED13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED13 Gene

Domains for MED13 Gene

Protein Domains for MED13 Gene

UniProtKB/Swiss-Prot:

MED13_HUMAN
Family:
  • Belongs to the Mediator complex subunit 13 family.:
    • Q9UHV7
genes like me logo Genes that share domains with MED13: view

No data available for Gene Families for MED13 Gene

Function for MED13 Gene

Molecular function for MED13 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IDA 12037571
GO:0004872 receptor activity IDA 12218053
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity NAS 10235266
genes like me logo Genes that share ontologies with MED13: view
genes like me logo Genes that share phenotypes with MED13: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED13 Gene

Localization for MED13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED13 Gene COMPARTMENTS Subcellular localization image for MED13 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IDA 10198638
genes like me logo Genes that share ontologies with MED13: view

Pathways for MED13 Gene

genes like me logo Genes that share pathways with MED13: view

Pathways by source for MED13 Gene

Gene Ontology (GO) - Biological Process for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0030518 intracellular steroid hormone receptor signaling pathway IDA 11867769
GO:0030521 androgen receptor signaling pathway IDA 12218053
genes like me logo Genes that share ontologies with MED13: view

Transcripts for MED13 Gene

Unigene Clusters for MED13 Gene

Mediator complex subunit 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED13 Gene

No ASD Table

Relevant External Links for MED13 Gene

GeneLoc Exon Structure for
MED13
ECgene alternative splicing isoforms for
MED13

Expression for MED13 Gene

mRNA expression in normal human tissues for MED13 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MED13 Gene

SOURCE GeneReport for Unigene cluster for MED13 Gene Hs.282678

mRNA Expression by UniProt/SwissProt for MED13 Gene

Q9UHV7-MED13_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with MED13: view

Orthologs for MED13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED13 36
  • 99.75 (n)
  • 99.68 (a)
MED13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED13 36
  • 94.99 (n)
  • 95.68 (a)
MED13 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED13 36
  • 95.44 (n)
  • 96.14 (a)
MED13 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med13 36
  • 91.85 (n)
  • 93.6 (a)
Med13 16
Med13 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED13 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED13 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med13 36
  • 91.54 (n)
  • 93.33 (a)
chicken
(Gallus gallus)
Aves MED13 36
  • 81.75 (n)
  • 88.03 (a)
MED13 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.10542 36
tropical clawed frog
(Silurana tropicalis)
Amphibia med13 36
  • 75.12 (n)
  • 80.45 (a)
Str.10799 36
zebrafish
(Danio rerio)
Actinopterygii Dr.13644 36
med13a 36
  • 66.71 (n)
  • 71.23 (a)
med13a 37
  • 70 (a)
OneToMany
med13b 37
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta skd 36
  • 48.4 (n)
  • 40.91 (a)
skd 37
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-19 37
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2069 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for MED13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED13 Gene

ENSEMBL:
Gene Tree for MED13 (if available)
TreeFam:
Gene Tree for MED13 (if available)

Paralogs for MED13 Gene

Paralogs for MED13 Gene

Selected SIMAP similar genes for MED13 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MED13 Gene

genes like me logo Genes that share paralogs with MED13: view

Variants for MED13 Gene

Sequence variations from dbSNP and Humsavar for MED13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9977 -- 61,944,705(-) TACTT(A/C)AGTGT utr-variant-3-prime
rs671347 -- 61,966,523(-) GCTGA(C/T)GGTAA reference, synonymous-codon
rs679447 -- 61,975,005(+) AAAAA(A/C)AGGAA intron-variant
rs682166 -- 61,975,609(+) agcta(C/T)caggg intron-variant
rs685240 -- 61,949,905(-) cagtt(C/T)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED13 Gene

Variant ID Type Subtype PubMed ID
nsv112179 CNV Loss 16902084

Relevant External Links for MED13 Gene

HapMap Linkage Disequilibrium report
MED13
Human Gene Mutation Database (HGMD)
MED13

Disorders for MED13 Gene

Relevant External Links for MED13

Genetic Association Database (GAD)
MED13
Human Genome Epidemiology (HuGE) Navigator
MED13
genes like me logo Genes that share disorders with MED13: view

No data available for UniProtKB/Swiss-Prot for MED13 Gene

Publications for MED13 Gene

  1. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PMID: 10198638) Ito M. … Roeder R.G. (Mol. Cell 1999) 3 4
  2. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PMID: 10235266) Rachez C. … Freedman L.P. (Nature 1999) 3 4
  3. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PMID: 10235267) Naeaer A.M. … Tjian R. (Nature 1999) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4

Products for MED13 Gene

Sources for MED13 Gene

Back to Top

Content