Aliases for MED13 Gene
Aliases for MED13 Gene
- Mediator Complex Subunit 13 2 3 4 5
- Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component 3 4
- Vitamin D3 Receptor-Interacting Protein Complex Component DRIP250 3 4
- Activator-Recruited Cofactor 250 KDa Component 3 4
- Thyroid Hormone Receptor-Associated Protein 1 3 4
- DRIP250 3 4
- TRAP240 3 4
- THRAP1 3 4
- ARC250 3 4
- Thyroid Hormone Receptor-Associated Protein Complex Component TRAP240 3
- Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog 3
- Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit 3
- Mediator Of RNA Polymerase II Transcription Subunit 13 3
- Thyroid Hormone Receptor Associated Protein 1 2
- KIAA0593 4
- HSPC221 3
External Ids for MED13 Gene
- HGNC: 22474
- Entrez Gene: 9969
- Ensembl: ENSG00000108510
- OMIM: 603808
- UniProtKB: Q9UHV7
Previous HGNC Symbols for MED13 Gene
- THRAP1
Previous GeneCards Identifiers for MED13 Gene
- GC17M057374
- GC17M060019
- GC17M055388
Summaries for MED13 Gene
-
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]
GeneCards Summary for MED13 Gene
MED13 (Mediator Complex Subunit 13) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include receptor activity and transcription cofactor activity. An important paralog of this gene is MED13L.
UniProtKB/Swiss-Prot for MED13 Gene
-
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED13 Gene
Genomics for MED13 Gene
Regulatory Elements for MED13 Gene
Enhancers for MED13 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G062062 | 1.5 | FANTOM5 ENCODE | 29.5 | +0.8 | 817 | 4.3 | MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC | MED13 BRIP1 NACA2 ENSG00000200842 |
| GH17G061489 | 1.2 | Ensembl ENCODE | 30.5 | +575.1 | 575144 | 2.1 | FOXA2 ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 FOS ZNF263 SP5 REST | APPBP2 MED13 INTS2 PPM1D TBX4 NACA2 ENSG00000267137 |
| GH17G062477 | 1.3 | ENCODE dbSUPER | 18.8 | -413.9 | -413858 | 3.7 | SIN3A ZNF48 ZBTB7B YY1 GLIS2 ELK1 CBX5 SP3 CEBPZ MXD4 | MED13 MRC2 METTL2A INTS2 TLK2 RPS10P26 |
| GH17G061815 | 1.6 | VISTA ENCODE | 13.9 | +249.0 | 249008 | 1.1 | HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 | MED13 BRIP1 GC17M061751 GC17P061743 |
| GH17G062789 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | -726.8 | -726847 | 5.9 | HDGF PKNOX1 FOXA2 SIN3A YBX1 FEZF1 ZBTB7B ZNF207 FOS SP3 | DDX42 INTS2 MED13 MIR633 STRADA MARCH10 GC17M062789 GC17M062752 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MED13 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MED13 Gene
- Chromosome:
- 17
- Start:
- 61,942,605 bp from pter
- End:
- 62,065,311 bp from pter
- Size:
- 122,707 bases
- Orientation:
- Minus strand
Genomic View for MED13 Gene
Genes around MED13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.2 by Ensembl
- 17q23.2 by Entrez Gene
- 17q23.2 by HGNC
MED13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MED13 Gene
Proteins for MED13 Gene
-
Protein details for MED13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UHV7-MED13_HUMAN
- Recommended name:
- Mediator of RNA polymerase II transcription subunit 13
- Protein Accession:
- Q9UHV7
- B2RU05
- O60334
Protein attributes for MED13 Gene
- Size:
- 2174 amino acids
- Molecular mass:
- 239297 Da
- Quaternary structure:
-
- Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
- SequenceCaution:
-
- Sequence=AAD22032.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Protein Expression for MED13 Gene
Post-translational modifications for MED13 Gene
Other Protein References for MED13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MED13
- Invitrogen Antibodies for MED13
- antibodies-online Antibodies for MED13: See all 16
- GeneTex MED13 antibody for MED13
-
Santa Cruz Biotechnology (SCBT) Antibodies for MED13
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MED13
- Origene Custom Protein Services for MED13
- Novus Biologicals proteins for MED13
- Search GeneTex for Proteins for MED13
Assay Products
- antibodies-online Kits for MED13: See all 19
No data available for DME Specific Peptides for MED13 Gene
Domains & Families for MED13 Gene
Gene Families for MED13 Gene
- HGNC:
Protein Domains for MED13 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MED13 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UHV7- Family:
-
- Belongs to the Mediator complex subunit 13 family.
Function for MED13 Gene
Molecular function for MED13 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity | IDA | 10198638 |
| GO:0003712 | transcription cofactor activity | IDA | 12218053 |
| GO:0003713 | transcription coactivator activity | IDA | 12037571 |
| GO:0004872 | receptor activity | IDA | 12218053 |
| GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity | NAS | 10235266 |
Phenotypes for MED13 Gene
- MGI mutant phenotypes for MED13:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MED13:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MED13
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MED13 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MED13 gene
- Search ViGene Biosciences for MED13
CRISPR Products
-
OriGene CRISPR knockouts for MED13
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED13
- GenScript: Design CRISPR guide RNA sequences for MED13
miRNA for MED13 Gene
- miRTarBase miRNAs that target MED13
-
- hsa-mir-208a-3p (MIRT003912)
- hsa-mir-151a-3p (MIRT019505)
- hsa-mir-103a-3p (MIRT027154)
- hsa-mir-16-5p (MIRT031923)
- hsa-mir-1303 (MIRT035880)
- hsa-mir-30c-5p (MIRT047970)
- hsa-mir-196a-5p (MIRT048177)
- hsa-mir-17-5p (MIRT050942)
- hsa-let-7b-5p (MIRT052192)
- hsa-mir-141-3p (MIRT078340)
- hsa-mir-200a-3p (MIRT078341)
- hsa-mir-495-3p (MIRT078342)
- hsa-mir-5688 (MIRT078346)
- hsa-mir-27a-3p (MIRT197755)
- hsa-mir-27b-3p (MIRT197757)
- hsa-mir-5580-3p (MIRT197788)
- hsa-mir-8084 (MIRT234566)
- hsa-mir-6831-3p (MIRT406383)
- hsa-mir-205-5p (MIRT440259)
- ebv-mir-bart7-3p (MIRT440261)
- hsa-mir-5585-5p (MIRT501894)
- hsa-mir-548ax (MIRT501895)
- hsa-mir-548ao-5p (MIRT501896)
- hsa-mir-6811-5p (MIRT501897)
- hsa-mir-6511b-5p (MIRT501898)
- hsa-mir-5585-3p (MIRT501899)
- hsa-mir-4708-5p (MIRT501900)
- hsa-mir-1253 (MIRT501901)
- hsa-mir-153-5p (MIRT501902)
- hsa-mir-95-5p (MIRT501903)
- hsa-mir-5197-3p (MIRT501904)
- hsa-mir-338-5p (MIRT501905)
- hsa-mir-5692a (MIRT501906)
- hsa-mir-3591-5p (MIRT535997)
- hsa-mir-4460 (MIRT535998)
- hsa-mir-4727-3p (MIRT535999)
- hsa-mir-4775 (MIRT536000)
- hsa-mir-7160-5p (MIRT536001)
- hsa-mir-3605-5p (MIRT536002)
- hsa-mir-3679-5p (MIRT536003)
- hsa-mir-1185-5p (MIRT536004)
- hsa-mir-27b-5p (MIRT536005)
- hsa-mir-6718-5p (MIRT536006)
- hsa-mir-203b-5p (MIRT536007)
- hsa-mir-590-3p (MIRT536008)
- hsa-mir-562 (MIRT536009)
- hsa-mir-140-5p (MIRT536010)
- hsa-mir-568 (MIRT547439)
- hsa-mir-4477a (MIRT547440)
- hsa-mir-3163 (MIRT547441)
- hsa-mir-595 (MIRT547442)
- hsa-mir-224-5p (MIRT547443)
- hsa-mir-4783-5p (MIRT609936)
- hsa-mir-362-3p (MIRT609937)
- hsa-mir-329-3p (MIRT609938)
- hsa-mir-8485 (MIRT609939)
miRNA Products
- Search ViGene Biosciences for MED13
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for MED13 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for MED13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MED13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MED13
-
ViGene Biosciences adenoviral particle packaged cDNA for MED13 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MED13 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MED13 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED13 Gene
Localization for MED13 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MED13 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 10235267 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016020 | membrane | IDA | 19946888 |
| GO:0016592 | mediator complex | IDA | 10198638 |
Pathways & Interactions for MED13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Gene Expression |
.48
|
|
| 3 | Metabolism |
.37
|
|
| 4 | Thyroid hormone signaling pathway | ||
| 5 | PEDF Induced Signaling | ||
Pathways by source for MED13 Gene
9 Reactome pathways for MED13 Gene
1 KEGG pathway for MED13 Gene
1 GeneGo (Thomson Reuters) pathway for MED13 Gene
1 Qiagen pathway for MED13 Gene
Interacting Proteins for MED13 Gene
Selected Interacting proteins:
Q9UHV7-MED13_HUMAN
ENSP00000380888
for MED13 Gene via
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0030518 | intracellular steroid hormone receptor signaling pathway | IDA | 11867769 |
No data available for SIGNOR curated interactions for MED13 Gene
Transcripts for MED13 Gene
mRNA/cDNA for MED13 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (281) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MED13 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MED13
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED13
- GenScript: Design CRISPR guide RNA sequences for MED13
miRNA Products
- Search ViGene Biosciences for MED13
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MED13
- Browse OriGene Inhibitory RNA Products For MED13
-
ViGene Biosciences ready-to-package AAV shRNAs for MED13 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MED13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MED13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for MED13 Gene
This gene is overexpressed in Placenta (27.4), Blymphocyte (25.2), and CD8 Tcells (13.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MED13 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MED13 Gene:
MED13SOURCE GeneReport for Unigene cluster for MED13 Gene:
Hs.282678mRNA Expression by UniProt/SwissProt for MED13 Gene:
Q9UHV7-MED13_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for MED13 Gene
- Nervous system(4.5)
- Liver(4.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for MED13
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED13 Gene
Orthologs for MED13 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MED13 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MED13 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MED13 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Med13 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Med13 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MED13 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MED13 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MED13 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | med13 34 |
|
||
| Str.10799 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10542 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | med13a 34 35 |
|
||
| med13b 35 |
|
OneToMany | |||
| Dr.13644 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | skd 35 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | let-19 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2069 34 |
|
- Species where no ortholog for MED13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MED13 Gene
(1) SIMAP similar genes for MED13 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for MED13 Gene
Variants for MED13 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs773685207 | Uncertain significance | 61,966,645(+) | TAATC(A/G/T)ACAGG | reference, synonymous-codon | |
| rs864309592 | Uncertain significance | 61,962,868(-) | CATAC(A/G)AAAAT | reference, missense | |
| rs140673828 | Benign | 61,965,208(+) | TCCAC(C/T)ATTCA | reference, missense | |
| rs1000033417 | -- | 62,066,319(+) | GCAGG(C/G/T)GCAAA | upstream-variant-2KB | |
| rs1000035834 | -- | 62,017,237(+) | AAAAA(A/G)GCATG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3640960 | CNV | loss | 21293372 |
| nsv1109098 | CNV | deletion | 24896259 |
| nsv112179 | CNV | deletion | 16902084 |
| nsv1138564 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
0.849% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.95;
59.77% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MED13 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED13 Gene
Disorders for MED13 Gene
Relevant External Links for MED13
No disorders were found for MED13 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED13 Gene
Publications for MED13 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I. … Robledo M. (PLoS Genet. 2009) 3 46 64
- MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 64
- A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4 64
- Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PMID: 10198638) Ito M. … Roeder R.G. (Mol. Cell 1999) 3 4 64
Products for MED13 Gene
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- antibodies-online Antibodies for MED13: See all 16
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MED13
- VectorBuilder custom plasmid, inducible vectors for MED13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MED13
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MED13 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer