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MED13 Gene

protein-coding GIFtS: 54
GCID: GC17M060019

Mediator Complex Subunit 13

(Previous name: thyroid hormone receptor associated protein 1)
(Previous symbol: THRAP1)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Mediator Complex Subunit 13¹ ² ³		DRIP250² ³
THRAP1¹ ² ³ ⁵		HSPC221²
TRAP240² ³ ⁵		Mediator Of RNA Polymerase II Transcription Subunit 13²
Thyroid Hormone Receptor Associated Protein 1¹ ²		Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog²
Activator-Recruited Cofactor 250 KDa Component² ³		Thyroid Hormone Receptor-Associated Protein Complex Component TRAP240²
Thyroid Hormone Receptor-Associated Protein 1² ³		Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit²
Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component² ³		KIAA0593³
Vitamin D3 Receptor-Interacting Protein Complex Component DRIP250² ³		Trap240³
ARC250² ³

External Ids:	HGNC: 22474¹	Entrez Gene: 9969²	Ensembl: ENSG00000108510⁷	OMIM: 603808⁵	UniProtKB: Q9UHV7³

Export aliases for MED13 gene to outside databases

Previous GC identifers: GC17M057374 GC17M055388

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED13 Gene:

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional

coactivator complex thought to be required for the expression of almost all genes. The mediator complex is

recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting

with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of

this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate

transactivation by mediator. (provided by RefSeq, Jul 2008)

GeneCards Summary for MED13 Gene:

MED13 (mediator complex subunit 13) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity. An important paralog of this gene is MED13L.

UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7

Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all

RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific

regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by

direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional

preinitiation complex with RNA polymerase II and the general transcription factors

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10 NC_018928.2 NT_010783.16

Regulatory elements:

Regulatory transcription factor binding sites in the MED13 gene promoter:
AML1a ATF-2 Lmo2 E47 Meis-1b CRE-BP1 Pax-3 Meis-1a RSRFC4 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MED13 promoter sequence

Search Chromatin IP Primers for MED13

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q22-q23

MED13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED13 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M060019: view genomic region (about GC identifiers)

Start:	60,019,966 bp from pter	End:	60,142,643 bp from pter
Size:	122,678 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7 (See protein sequence)

Recommended Name: Mediator of RNA polymerase II transcription subunit 13

Size: 2174 amino acids; 239297 Da

Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,

MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,

MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct

module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this

module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or

more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP

Sequence caution: Sequence=AAD22032.1; Type=Frameshift; Positions=Several;

Secondary accessions: B2RU05 O60334

Explore the universe of human proteins at neXtProt for MED13: NX_Q9UHV7

Explore proteomics data for MED13 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See MED13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005112.2

ENSEMBL proteins:

ENSP00000380888 ENSP00000464131

Reactome Protein details: Q9UHV7

MED13 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for MED13
	GenScript Custom Purified and Recombinant Proteins Services for MED13
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for MED13
	Search antibodies-online for proteins for MED13
	Search antibodies-online for peptides for MED13

MED13 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for MED13 OriGene Custom Antibody Services for MED13
	Novus Biologicals MED13 Antibodies
	Search for Antibodies for MED13 at Abcam
	Browse Antibodies at Cloud-Clone Corp.
	Search ThermoFisher Antibodies for MED13
	antibodies-online antibodies for MED13 (12 products)

MED13 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MED13
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MED13
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for MED13
	antibodies-online kits for MED13 (16 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR021643 Mediator_Med13_N_met/fun

IPR009401 Mediator_Med13

Graphical View of Domain Structure for InterPro Entry Q9UHV7

ProtoNet protein and cluster: Q9UHV7

UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7

Similarity: Belongs to the Mediator complex subunit 13 family

Find genes that share domains with MED13 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MED13_HUMAN, Q9UHV7

Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all

RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific

regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by

direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional

preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001104	RNA polymerase II transcription cofactor activity	IDA	10198638
GO:0003712	transcription cofactor activity	IDA	12218053
GO:0003713	transcription coactivator activity	IDA	12037571
GO:0004872	receptor activity	IDA	12218053
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	NAS	10235266

Find genes that share ontologies with MED13 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for MED13:

Decreased POU5F1-GFP protein e

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Med13):

adipose tissue

cardiovascular system

growth/size/body

homeostasis/metabolism

liver/biliary system

Find genes that share phenotypes with MED13 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for MED13

miRNA Products:		miRTarBase miRNAs that target MED13: hsa-mir-208a-3p (MIRT003912), hsa-let-7b-5p (MIRT052192), hsa-mir-16-5p (MIRT031923), hsa-mir-196a-5p (MIRT048177), hsa-mir-103a-3p (MIRT027154), hsa-mir-17-5p (MIRT050942), hsa-mir-151a-3p (MIRT019505), hsa-mir-30c-5p (MIRT047970), hsa-mir-1303 (MIRT035880)

		Block miRNA regulation of human, mouse, rat MED13 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MED13 (see all 97):
		hsa-miR-140-5p hsa-miR-520f hsa-miR-1321 hsa-miR-3607-3p hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-134

		SwitchGear 3'UTR luciferase reporter plasmid: MED13 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MED13
		Predesigned siRNA for gene silencing in human, mouse, rat MED13

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MED13

Clone Products:		OriGene clones in human, mouse for MED13 (see all 5) OriGene ORF clones in mouse, rat for MED13 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MED13 (NM_005121)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED13
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED13

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MED13
		Browse ESI BIO Cell Lines and PureStem Progenitors for MED13

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MED13_HUMAN, Q9UHV7: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2
endoplasmic reticulum	1
mitochondrion	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	10235267
GO:0005654	nucleoplasm	TAS	--
GO:0016592	mediator complex	IDA	10198638

Find genes that share ontologies with MED13 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MED13 About (see all 6)

See pathways by source

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SuperPath

Contained pathways About

Fatty acid, triacylglycerol, and ketone body metabolism

	Fatty acid, triacylglycerol, and ketone body metabolism	0.65			PPARA Activates Gene Expression	0.63
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.65			Transcriptional Regulation of White Adipocyte Differentiation	0.38

Gene Expression

Generic Transcription Pathway

0.40

Gene Expression

0.40

Metabolism

Metabolism

0.38

Metabolism of lipids and lipoproteins

0.37

L1CAM interactions

Developmental Biology

0.63

Transcription_Ligand-Dependent Transcription of Retinoid-Target genes

Transcription_Ligand-Dependent Transcription of Retinoid-Target genes

Find genes that share SuperPaths with MED13 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MED13

Glucocorticoid Receptor Signaling

1 GeneGo (Thomson Reuters) Pathway for MED13

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

3 Reactome Pathways for MED13

	Transcriptional regulation of white adipocyte differentiation
	Generic Transcription Pathway
	PPARA activates gene expression

1 Kegg Pathway (Kegg details for MED13):

Thyroid hormone signaling pathway

Pathway & Disease-focused RT² Profiler PCR Array including MED13:

Nuclear Receptors & Coregulators in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for MED13

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MED13 (Q9UHV7^{2, 3} ENSP00000380888⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 143)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED1	Q15648²^,³, ENSP00000300651⁴	MINT-6744331 I2D: score=1 STRING: ENSP00000300651
MED12	Q93074²^,³, ENSP00000363193⁴	MINT-6744331 MINT-7010915 I2D: score=3 STRING: ENSP00000363193
TRRAP	Q9Y4A5²^,³, ENSP00000347733⁴	MINT-6744331 I2D: score=1 STRING: ENSP00000347733
MED23	Q9ULK4²^,³, ENSP00000357047⁴	MINT-6744331 I2D: score=3 STRING: ENSP00000357047
MED13L	Q71F56³, ENSP00000281928⁴	I2D: score=2 STRING: ENSP00000281928

About this table

Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0010467	gene expression	TAS	--
GO:0030518	intracellular steroid hormone receptor signaling pathway	IDA	11867769
GO:0030521	androgen receptor signaling pathway	IDA	12218053

Find genes that share ontologies with MED13 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MED13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MED13 gene:

NM_005121.2

Unigene Cluster for MED13:

Mediator complex subunit 13

Hs.282678 [show with all ESTs]

Unigene Representative Sequence: NM_005121

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000397786(uc002izo.3) ENST00000582786 ENST00000583958(uc002izp.3)

ENST00000581994 ENST00000578132 ENST00000580896

miRNA Products:		Block miRNA regulation of human, mouse, rat MED13 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MED13 (see all 97):
		hsa-miR-140-5p hsa-miR-520f hsa-miR-1321 hsa-miR-3607-3p hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-134

		SwitchGear 3'UTR luciferase reporter plasmid: MED13 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MED13
		Predesigned siRNA for gene silencing in human, mouse, rat MED13

Clone Products:		OriGene clones in human, mouse for MED13 (see all 5) OriGene ORF clones in mouse, rat for MED13 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MED13 (NM_005121)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED13
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED13

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MED13
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MED13
		QuantiTect SYBR Green Assays in human, mouse, rat MED13
		QuantiFast Probe-based Assays in human, mouse, rat MED13

Additional mRNA sequence:

AB011165.2 AF117754.1 AF151055.1 AK054894.1 AK124099.1 BC044258.1 BC140891.1

12 DOTS entries:

DT.452326 DT.100785751 DT.408817 DT.75144131 DT.100785756 DT.120956451 DT.91748799 DT.101977058

DT.86858782 DT.91748798 DT.91748811 DT.99953036

Selected AceView cDNA sequences (see all 281):

BX477453 AA255784 BI837972 AI954133 CA336432 BQ441612 AA480916 AI360826

AA665822 BQ709424 BC044258 R68630 AI433967 AI014911 AI274781 N40577

AA372209 BM979342 BI089982 AA243325 AA343200 AI376624 BQ946858 F29901

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MED13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGCCTTCAA

About this image

MED13 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MED13 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.282678

UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7

Tissue specificity: Ubiquitous

Pathway & Disease-focused RT² Profiler PCR Array including MED13:

Nuclear Receptors & Coregulators in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MED13
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MED13
		QuantiTect SYBR Green Assays in human, mouse, rat MED13
		QuantiFast Probe-based Assays in human, mouse, rat MED13

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MED13 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Med13^{1 , 5}	mediator complex subunit 13^{1, 5}	91.85(n)¹ 93.6(a)¹		11 (51.75 cM)⁵ 327987¹ NM_001080931.1¹ NP_001074400.1¹ 86267033⁵
chicken (Gallus gallus)	Aves	MED13¹	mediator complex subunit 13	81.75(n) 88.03(a)		417639 XM_004946720.1 XP_004946777.1
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	86(a) 64(a)	1 ↔ many 1 ↔ many	GL345053.1(785-9604) GL343470.1(14622-139110)
African clawed frog (Xenopus laevis)	Amphibia	Xl.10542²	Xenopus laevis transcribed sequence with strong similarity more	88.84(n)		CA982815.1
zebrafish (Danio rerio)	Actinopterygii	Dr.13644²	Transcribed sequence with moderate similarity to protein more	74.68(n)		CD594740.1
fruit fly (Drosophila melanogaster)	Insecta	skd¹	skuld	48.4(n) 40.91(a)		43906 NM_001275205.1 NP_001262134.1
worm (Caenorhabditis elegans)	Secernentea	let-19⁶	Protein LET-19 (let-19) mRNA, complete cds	16(a)	1 → many	II(8770975-8782021) WBGene00002295

ENSEMBL Gene Tree for MED13 (if available)
TreeFam Gene Tree for MED13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MED13 gene

MED13L²

1 SIMAP similar gene for MED13 using alignment to 2 protein entries: MED13_HUMAN (see all proteins):

MED13L

Find genes that share paralogs with MED13 About GenesLikeMe

2 Pseudogenes.org Pseudogenes for MED13
PGOHUM00000235428 PGOHUM00000233965

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141158845^1,2		--	55509853(+)	`AAACAA/GTGTAG`	1	--	int¹		0	--	--	--	--
rs137929286^1,2	C	--	60019467(+)	`TAGGC-/GGGTTC`	1	--	ds500¹		0	--	--	--	--
rs148037567^1,2	C	--	60019753(+)	`ACAAG-/GAATT GGTAG`	1	--	ds500¹		0	--	--	--	--
rs185515640^1,2		--	60019754(+)	`CAAGGA/CATTGG`	1	--	ds500¹		0	--	--	--	--
rs143595519^1,2		--	60019927(+)	`CAAATG/TTAATA`	1	--	ds500¹		0	--	--	--	--
rs190038315^1,2		--	60020023(+)	`TTTTTG/TTTTTT`	1	--	ut3¹		0	--	--	--	--
rs147189111^1,2		--	60020081(+)	`TCAGTA/GTTATG`	1	--	ut3¹		0	--	--	--	--
rs75729250^1,2	C	--	60020093(+)	`CATTCA/GGCAGC`	1	--	ut3¹		0	--	--	--	--
rs139441247^1,2	C	--	60020138(+)	`TTAAA-/AAGAAAAG`	1	--	cds¹		0	--	--	--	--
rs4198^1,2	F	--	60020140(+)	`TTAAAAAG/-AAAAG`	2	--	ut3¹		4		EU NA EA	342

HapMap Linkage Disequilibrium report for MED13 (60019966 - 60142643 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for MED13: About this table

Variant ID	Type	Subtype	PubMed ID
nsv112179	CNV	Loss	16902084

Human Gene Mutation Database (HGMD): MED13

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MED13

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603808 OMIM disorders: --

Find genes that share disorders with MED13 About GenesLikeMe

Genetic Association Database (GAD): MED13
Human Genome Epidemiology (HuGE) Navigator: MED13 (3 documents)

Export disorders for MED13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MED13 gene, integrated from 10 sources (see all 51):
(articles sorted by number of sources associating them with MED13)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)^{1, 4} Landa I....Robledo M. (PLoS Genet. 2009)
MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)^{1, 2} Zhang X....Roeder R.G. (Mol. Cell 2005)
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)^{1, 2} Sato S.... Conaway R.C. (Mol. Cell 2004)
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PubMed id 10198638)^{1, 2} Ito M.... Roeder R.G. (Mol. Cell 1999)
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)^{1, 2} Rachez C.... Freedman L.P. (Nature 1999)
Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)^{1, 2} Naeaer A.M....Tjian R. (Nature 1999)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2} Nagase T....Ohara O. (DNA Res. 1998)
A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)¹ Tsai K.L....Asturias F.J. (amp 2013)
The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)¹ Varjosalo M....Gstaiger M. (Cell Rep 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9969	HGNC: 22474	AceView: THRAP1	Ensembl:ENSG00000108510	euGenes: HUgn9969
ECgene: MED13	Kegg: 9969	H-InvDB: MED13

(According to HUGE)
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HUGE: KIAA0593

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MED13	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MED13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MED13 gene:
Search GeneIP for patents involving MED13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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MED13 Gene

Mediator Complex Subunit 13

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