Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MED13 Gene

protein-coding   GIFtS: 54
GCID: GC17M060019

Mediator Complex Subunit 13

(Previous name: thyroid hormone receptor associated protein 1)
(Previous symbol: THRAP1)
  Search for MED13
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mediator Complex Subunit 131 2 3     DRIP2502 3
THRAP11 2 3 5     HSPC2212
TRAP2402 3 5     Mediator Of RNA Polymerase II Transcription Subunit 132
Thyroid Hormone Receptor Associated Protein 11 2     Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog2
Activator-Recruited Cofactor 250 KDa Component2 3     Thyroid Hormone Receptor-Associated Protein Complex Component TRAP2402
Thyroid Hormone Receptor-Associated Protein 12 3     Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit2
Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component2 3     KIAA05933
Vitamin D3 Receptor-Interacting Protein Complex Component DRIP2502 3     Trap2403
ARC2502 3     

External Ids:    HGNC: 224741   Entrez Gene: 99692   Ensembl: ENSG000001085107   OMIM: 6038085   UniProtKB: Q9UHV73   

Export aliases for MED13 gene to outside databases

Previous GC identifers: GC17M057374 GC17M055388


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MED13 Gene:
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional
coactivator complex thought to be required for the expression of almost all genes. The mediator complex is
recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting
with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of
this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate
transactivation by mediator. (provided by RefSeq, Jul 2008)

GeneCards Summary for MED13 Gene:
MED13 (mediator complex subunit 13) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity. An important paralog of this gene is MED13L.

UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED13 gene promoter:
         AML1a   ATF-2   Lmo2   E47   Meis-1b   CRE-BP1   Pax-3   Meis-1a   RSRFC4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MED13 promoter sequence
   Search Chromatin IP Primers for MED13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q22-q23

MED13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M060019:  view genomic region     (about GC identifiers)

Start:
60,019,966 bp from pter      End:
60,142,643 bp from pter
Size:
122,678 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 13  
Size: 2174 amino acids; 239297 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Sequence caution: Sequence=AAD22032.1; Type=Frameshift; Positions=Several;
Secondary accessions: B2RU05 O60334

Explore the universe of human proteins at neXtProt for MED13: NX_Q9UHV7

Explore proteomics data for MED13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MED13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005112.2  
    ENSEMBL proteins: 
     ENSP00000380888   ENSP00000464131  
    Reactome Protein details: Q9UHV7

    MED13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MED13
    GenScript Custom Purified and Recombinant Proteins Services for MED13
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MED13 

    MED13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MED13
    OriGene Custom Antibody Services for MED13
    Novus Biologicals MED13 Antibodies
    Search for Antibodies for MED13 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for MED13
    LSBio Antibodies in human, mouse, rat for MED13

    MED13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MED13 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR021643 Mediator_Med13_N_met/fun
     IPR009401 Mediator_Med13

    Graphical View of Domain Structure for InterPro Entry Q9UHV7

    ProtoNet protein and cluster: Q9UHV7

    UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7
    Similarity: Belongs to the Mediator complex subunit 13 family


    Find genes that share domains with MED13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED13_HUMAN, Q9UHV7
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003712transcription cofactor activity IDA12218053
    GO:0003713transcription coactivator activity IDA12037571
    GO:0004872receptor activity IDA12218053
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity NAS10235266
         
    Find genes that share ontologies with MED13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MED13:
     Decreased POU5F1-GFP protein e 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Med13):
     adipose tissue  cardiovascular system  growth/size/body  homeostasis/metabolism  liver/biliary system 

    Find genes that share phenotypes with MED13           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED13

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED13:
    hsa-mir-208a-3p (MIRT003912), hsa-let-7b-5p (MIRT052192), hsa-mir-16-5p (MIRT031923), hsa-mir-196a-5p (MIRT048177), hsa-mir-103a-3p (MIRT027154), hsa-mir-17-5p (MIRT050942), hsa-mir-151a-3p (MIRT019505), hsa-mir-30c-5p (MIRT047970), hsa-mir-1303 (MIRT035880)

    Block miRNA regulation of human, mouse, rat MED13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED13 (see all 97):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-1321 hsa-miR-3607-3p hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-134
    SwitchGear 3'UTR luciferase reporter plasmidMED13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED13
    Predesigned siRNA for gene silencing in human, mouse, rat MED13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED13

    Clone
    Products:
         
    OriGene clones in human, mouse for MED13 (see all 5)
    OriGene ORF clones in mouse, rat for MED13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED13 (NM_005121)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED13
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MED13_HUMAN, Q9UHV7: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10235267
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA10198638

    Find genes that share ontologies with MED13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MED13 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes


    Find genes that share SuperPaths with MED13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MED13
        Glucocorticoid Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for MED13
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    3 Reactome Pathways for MED13
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression


    1 Kegg Pathway  (Kegg details for MED13):
        Thyroid hormone signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including MED13: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MED13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED13 (Q9UHV72, 3 ENSP000003808884) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156482, 3, ENSP000003006514MINT-6744331 I2D: score=1 STRING: ENSP00000300651
    MED12Q930742, 3, ENSP000003631934MINT-6744331 MINT-7010915 I2D: score=3 STRING: ENSP00000363193
    TRRAPQ9Y4A52, 3, ENSP000003477334MINT-6744331 I2D: score=1 STRING: ENSP00000347733
    MED23Q9ULK42, 3, ENSP000003570474MINT-6744331 I2D: score=3 STRING: ENSP00000357047
    MED13LQ71F563, ENSP000002819284I2D: score=2 STRING: ENSP00000281928
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030518intracellular steroid hormone receptor signaling pathway IDA11867769
    GO:0030521androgen receptor signaling pathway IDA12218053

    Find genes that share ontologies with MED13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED13



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MED13 gene: 
    NM_005121.2  

    Unigene Cluster for MED13:

    Mediator complex subunit 13
    Hs.282678  [show with all ESTs]
    Unigene Representative Sequence: NM_005121
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397786(uc002izo.3) ENST00000582786 ENST00000583958(uc002izp.3)
    ENST00000581994 ENST00000578132 ENST00000580896
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED13 (see all 97):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-1321 hsa-miR-3607-3p hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-134
    SwitchGear 3'UTR luciferase reporter plasmidMED13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED13
    Predesigned siRNA for gene silencing in human, mouse, rat MED13
    Clone
    Products:
         
    OriGene clones in human, mouse for MED13 (see all 5)
    OriGene ORF clones in mouse, rat for MED13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED13 (NM_005121)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED13
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MED13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED13
      QuantiTect SYBR Green Assays in human, mouse, rat MED13
      QuantiFast Probe-based Assays in human, mouse, rat MED13

    Additional mRNA sequence: 

    AB011165.2 AF117754.1 AF151055.1 AK054894.1 AK124099.1 BC044258.1 BC140891.1 

    12 DOTS entries:

    DT.452326  DT.100785751  DT.408817  DT.75144131  DT.100785756  DT.120956451  DT.91748799  DT.101977058 
    DT.86858782  DT.91748798  DT.91748811  DT.99953036 

    Selected AceView cDNA sequences (see all 281):

    BX477453 AA255784 BI837972 AI954133 CA336432 BQ441612 AA480916 AI360826 
    AA665822 BQ709424 BC044258 R68630 AI433967 AI014911 AI274781 N40577 
    AA372209 BM979342 BI089982 AA243325 AA343200 AI376624 BQ946858 F29901 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MED13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCTTCAA
    MED13 Expression
    About this image

    MED13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282678

    UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including MED13: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MED13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED13
    QuantiTect SYBR Green Assays in human, mouse, rat MED13
    QuantiFast Probe-based Assays in human, mouse, rat MED13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MED13 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med131 , 5 mediator complex subunit 131, 5 91.85(n)1
    93.6(a)1
      11 (51.75 cM)5
    3279871  NM_001080931.11  NP_001074400.11 
     862670335 
    chicken
    (Gallus gallus)
    Aves MED131 mediator complex subunit 13 81.75(n)
    88.03(a)
      417639  XM_004946720.1  XP_004946777.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    86(a)
    64(a)
    1 ↔ many
    1 ↔ many
    GL345053.1(785-9604)
    GL343470.1(14622-139110)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.105422 Xenopus laevis transcribed sequence with strong similarity more 88.84(n)    CA982815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.136442 Transcribed sequence with moderate similarity to protein more 74.68(n)    CD594740.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta skd1 skuld 48.4(n)
    40.91(a)
      43906  NM_001275205.1  NP_001262134.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-196
    Protein LET-19 (let-19) mRNA, complete cds
    16(a)
    1 → many
    II(8770975-8782021) WBGene00002295


    ENSEMBL Gene Tree for MED13 (if available)
    TreeFam Gene Tree for MED13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MED13 gene
    MED13L2  
    1 SIMAP similar gene for MED13 using alignment to 2 protein entries:     MED13_HUMAN (see all proteins):
    MED13L

    Find genes that share paralogs with MED13           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MED13
    PGOHUM00000235428 PGOHUM00000233965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MED13 (see all 2547)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411588451,2
    --55509853(+) AAACAA/GTGTAG 1 -- int10--------
    rs1379292861,2
    C--60019467(+) TAGGC-/GGGTTC 1 -- ds50010--------
    rs1480375671,2
    C--60019753(+) ACAAG-/GAATT 
            
    GGTAG
    1 -- ds50010--------
    rs1855156401,2
    --60019754(+) CAAGGA/CATTGG 1 -- ds50010--------
    rs1435955191,2
    --60019927(+) CAAATG/TTAATA 1 -- ds50010--------
    rs1900383151,2
    --60020023(+) TTTTTG/TTTTTT 1 -- ut310--------
    rs1471891111,2
    --60020081(+) TCAGTA/GTTATG 1 -- ut310--------
    rs757292501,2
    C--60020093(+) CATTCA/GGCAGC 1 -- ut310--------
    rs1394412471,2
    C--60020138(+) TTAAA-/AAGAAAAG 1 -- cds10--------
    rs41981,2
    F--60020140(+) TTAAAAAG/-AAAAG 2 -- ut314Minor allele frequency- -:0.12EU NA EA 342

    HapMap Linkage Disequilibrium report for MED13 (60019966 - 60142643 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MED13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv112179CNV Loss16902084

    Human Gene Mutation Database (HGMD): MED13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED13
    DNA2.0 Custom Variant and Variant Library Synthesis for MED13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603808    OMIM disorders: --


    Find genes that share disorders with MED13           About GenesLikeMe

    Genetic Association Database (GAD): MED13
    Human Genome Epidemiology (HuGE) Navigator: MED13 (3 documents)

    Export disorders for MED13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MED13 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with MED13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    5. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PubMed id 10198638)1, 2 Ito M.... Roeder R.G. (Mol. Cell 1999)
    6. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2 Rachez C.... Freedman L.P. (Nature 1999)
    7. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (Nature 1999)
    8. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    9. A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)1 Tsai K.L....Asturias F.J. (amp 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9969 HGNC: 22474 AceView: THRAP1 Ensembl:ENSG00000108510 euGenes: HUgn9969
    ECgene: MED13 Kegg: 9969 H-InvDB: MED13

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0593

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MED13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MED13 gene:
    Search GeneIP for patents involving MED13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MED13   OriGene RNAi products in human, mouse, rat for MED13  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MED13  
     OriGene qSTAR qPCR primer pairs in human, mouse for MED13   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MED13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MED13   OriGene Custom Protein Services for MED13  

     
     
     Block miRNA regulation of human, mouse, rat MED13 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MED13
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED13 Predesigned siRNA for gene silencing in human, mouse, rat MED13
     QuantiFast Probe-based Assays in human, mouse, rat MED13 QuantiTect SYBR Green Assays in human, mouse, rat MED13
     PCR Arrays including human, mouse, rat MED13 Search Chromatin IP Primers for MED13
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED13  Search GeneGlobe Interaction Network for MED13
     Regulatory tfbs in MED13 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MED13 GenScript cDNA clones with any tag delivered in your preferred vector for MED13
     GenScript Custom Assay Services for MED13 GenScript Custom overexpressing Cell Line Services for MED13
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MED13
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MED13 antibodies
     Search for Antibodies for MED13 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MED13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MED13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13
     SwitchGear 3'UTR luciferase reporter plasmids for MED13
     SwitchGear Promoter luciferase reporter plasmids for MED13
     Search ThermoFisher Antibodies for MED13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED13
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED13
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED13
     LSBio Antibodies in human, mouse, rat for MED13
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MED13
      Search eBioscience for proteins for MED13
      Search eBioscience for elisas for MED13
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MED13 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4