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Aliases for MED13 Gene

Aliases for MED13 Gene

  • Mediator Complex Subunit 13 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex Component DRIP250 3 4
  • Activator-Recruited Cofactor 250 KDa Component 3 4
  • Thyroid Hormone Receptor Associated Protein 1 2 3
  • Thyroid Hormone Receptor-Associated Protein 1 3 4
  • DRIP250 3 4
  • TRAP240 3 4
  • THRAP1 3 4
  • ARC250 3 4
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP240 3
  • Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog 3
  • Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit 3
  • KIAA0593 4
  • HSPC221 3

External Ids for MED13 Gene

Previous HGNC Symbols for MED13 Gene

  • THRAP1

Previous GeneCards Identifiers for MED13 Gene

  • GC17M057374
  • GC17M060019
  • GC17M055388

Summaries for MED13 Gene

Entrez Gene Summary for MED13 Gene

  • This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED13 Gene

MED13 (Mediator Complex Subunit 13) is a Protein Coding gene. Diseases associated with MED13 include med23. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include receptor activity and transcription cofactor activity. An important paralog of this gene is MED13L.

UniProtKB/Swiss-Prot for MED13 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED13 Gene

Genomics for MED13 Gene

Regulatory Elements for MED13 Gene

Promoters for MED13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED13 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED13 Gene

Chromosome:
17
Start:
61,942,605 bp from pter
End:
62,065,311 bp from pter
Size:
122,707 bases
Orientation:
Minus strand

Genomic View for MED13 Gene

Genes around MED13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED13 Gene

Proteins for MED13 Gene

  • Protein details for MED13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV7-MED13_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 13
    Protein Accession:
    Q9UHV7
    Secondary Accessions:
    • B2RU05
    • O60334

    Protein attributes for MED13 Gene

    Size:
    2174 amino acids
    Molecular mass:
    239297 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAD22032.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MED13 Gene

Proteomics data for MED13 Gene at MOPED

Post-translational modifications for MED13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED13 Gene

Domains & Families for MED13 Gene

Gene Families for MED13 Gene

Protein Domains for MED13 Gene

Suggested Antigen Peptide Sequences for MED13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHV7

UniProtKB/Swiss-Prot:

MED13_HUMAN :
  • Belongs to the Mediator complex subunit 13 family.
Family:
  • Belongs to the Mediator complex subunit 13 family.
genes like me logo Genes that share domains with MED13: view

Function for MED13 Gene

Molecular function for MED13 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IDA 12218053
GO:0004872 receptor activity IDA 12218053
genes like me logo Genes that share ontologies with MED13: view
genes like me logo Genes that share phenotypes with MED13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MED13

miRNA for MED13 Gene

miRTarBase miRNAs that target MED13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED13 Gene

Localization for MED13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED13 Gene COMPARTMENTS Subcellular localization image for MED13 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IEA,IDA 10198638
genes like me logo Genes that share ontologies with MED13: view

Pathways & Interactions for MED13 Gene

genes like me logo Genes that share pathways with MED13: view

Gene Ontology (GO) - Biological Process for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0042632 cholesterol homeostasis IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12037571
genes like me logo Genes that share ontologies with MED13: view

No data available for SIGNOR curated interactions for MED13 Gene

Drugs & Compounds for MED13 Gene

No Compound Related Data Available

Transcripts for MED13 Gene

Unigene Clusters for MED13 Gene

Mediator complex subunit 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED13 Gene

No ASD Table

Relevant External Links for MED13 Gene

GeneLoc Exon Structure for
MED13
ECgene alternative splicing isoforms for
MED13

Expression for MED13 Gene

mRNA expression in normal human tissues for MED13 Gene

Protein differential expression in normal tissues from HIPED for MED13 Gene

This gene is overexpressed in Placenta (27.4), Blymphocyte (25.2), and CD8 Tcells (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MED13 Gene



SOURCE GeneReport for Unigene cluster for MED13 Gene Hs.282678

mRNA Expression by UniProt/SwissProt for MED13 Gene

Q9UHV7-MED13_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MED13: view

Protein tissue co-expression partners for MED13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MED13 Gene

Orthologs for MED13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED13 35
  • 94.99 (n)
  • 95.68 (a)
MED13 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED13 35
  • 95.44 (n)
  • 96.14 (a)
MED13 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med13 35
  • 91.85 (n)
  • 93.6 (a)
Med13 16
Med13 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED13 35
  • 99.75 (n)
  • 99.68 (a)
MED13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med13 35
  • 91.54 (n)
  • 93.33 (a)
oppossum
(Monodelphis domestica)
Mammalia MED13 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED13 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED13 35
  • 81.75 (n)
  • 88.03 (a)
MED13 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia med13 35
  • 75.12 (n)
  • 80.45 (a)
Str.10799 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10542 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13644 35
med13a 35
  • 66.71 (n)
  • 71.23 (a)
med13a 36
  • 70 (a)
OneToMany
med13b 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta skd 35
  • 48.4 (n)
  • 40.91 (a)
skd 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-19 36
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2069 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for MED13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED13 Gene

ENSEMBL:
Gene Tree for MED13 (if available)
TreeFam:
Gene Tree for MED13 (if available)

Paralogs for MED13 Gene

Paralogs for MED13 Gene

(1) SIMAP similar genes for MED13 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MED13 Gene

genes like me logo Genes that share paralogs with MED13: view

Variants for MED13 Gene

Sequence variations from dbSNP and Humsavar for MED13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34805963 - 61,968,118(+) ATAGG(C/G/T)TATAT reference, missense
rs35996128 - 61,968,073(+) TTTTG(C/G)TCCAT reference, missense
rs9977 -- 61,944,705(-) TACTT(A/C)AGTGT utr-variant-3-prime
rs671347 -- 61,966,523(-) GCTGA(C/T)GGTAA reference, synonymous-codon
rs682166 -- 61,975,609(+) agcta(C/T)caggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED13 Gene

Variant ID Type Subtype PubMed ID
nsv112179 CNV Loss 16902084

Variation tolerance for MED13 Gene

Residual Variation Intolerance Score: 0.849% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED13 Gene

HapMap Linkage Disequilibrium report
MED13
Human Gene Mutation Database (HGMD)
MED13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED13 Gene

Disorders for MED13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MED13 Gene - From: GeneCards

Disorder Aliases PubMed IDs
med23
  • autosomal recessive nonsyndromic mental retardation-18
- elite association - COSMIC cancer census association via MalaCards
Search MED13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MED13

Genetic Association Database (GAD)
MED13
Human Genome Epidemiology (HuGE) Navigator
MED13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED13
genes like me logo Genes that share disorders with MED13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED13 Gene

Publications for MED13 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  3. DNA Damage Regulates Translation through I^-TRCP Targeting of CReP. (PMID: 26091241) Loveless T.B. … Toczyski D.P. (PLoS Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MED13 Gene

Sources for MED13 Gene

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