Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MED13 Gene

Aliases for MED13 Gene

  • Mediator Complex Subunit 13 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component 3 4
  • Vitamin D3 Receptor-Interacting Protein Complex Component DRIP250 3 4
  • Activator-Recruited Cofactor 250 KDa Component 3 4
  • Thyroid Hormone Receptor-Associated Protein 1 3 4
  • DRIP250 3 4
  • TRAP240 3 4
  • THRAP1 3 4
  • ARC250 3 4
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP240 3
  • Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog 3
  • Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit 3
  • Mediator Of RNA Polymerase II Transcription Subunit 13 3
  • Thyroid Hormone Receptor Associated Protein 1 2
  • KIAA0593 4
  • HSPC221 3

External Ids for MED13 Gene

Previous HGNC Symbols for MED13 Gene

  • THRAP1

Previous GeneCards Identifiers for MED13 Gene

  • GC17M057374
  • GC17M060019
  • GC17M055388

Summaries for MED13 Gene

Entrez Gene Summary for MED13 Gene

  • This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED13 Gene

MED13 (Mediator Complex Subunit 13) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include receptor activity and transcription cofactor activity. An important paralog of this gene is MED13L.

UniProtKB/Swiss-Prot for MED13 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED13 Gene

Genomics for MED13 Gene

Regulatory Elements for MED13 Gene

Enhancers for MED13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G062062 1.5 FANTOM5 ENCODE 29.5 +0.8 817 4.3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MED13 BRIP1 NACA2 ENSG00000200842
GH17G061489 1.2 Ensembl ENCODE 30.5 +575.1 575144 2.1 FOXA2 ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 FOS ZNF263 SP5 REST APPBP2 MED13 INTS2 PPM1D TBX4 NACA2 ENSG00000267137
GH17G062477 1.3 ENCODE dbSUPER 18.8 -413.9 -413858 3.7 SIN3A ZNF48 ZBTB7B YY1 GLIS2 ELK1 CBX5 SP3 CEBPZ MXD4 MED13 MRC2 METTL2A INTS2 TLK2 RPS10P26
GH17G061815 1.6 VISTA ENCODE 13.9 +249.0 249008 1.1 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MED13 BRIP1 GC17M061751 GC17P061743
GH17G062789 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -726.8 -726847 5.9 HDGF PKNOX1 FOXA2 SIN3A YBX1 FEZF1 ZBTB7B ZNF207 FOS SP3 DDX42 INTS2 MED13 MIR633 STRADA MARCH10 GC17M062789 GC17M062752
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED13 on UCSC Golden Path with GeneCards custom track

Promoters for MED13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096639 511 2801 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for MED13 Gene

Chromosome:
17
Start:
61,942,605 bp from pter
End:
62,065,311 bp from pter
Size:
122,707 bases
Orientation:
Minus strand

Genomic View for MED13 Gene

Genes around MED13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED13 Gene

Proteins for MED13 Gene

  • Protein details for MED13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV7-MED13_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 13
    Protein Accession:
    Q9UHV7
    Secondary Accessions:
    • B2RU05
    • O60334

    Protein attributes for MED13 Gene

    Size:
    2174 amino acids
    Molecular mass:
    239297 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAD22032.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MED13 Gene

Post-translational modifications for MED13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED13 Gene

No data available for DME Specific Peptides for MED13 Gene

Domains & Families for MED13 Gene

Gene Families for MED13 Gene

Protein Domains for MED13 Gene

Suggested Antigen Peptide Sequences for MED13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHV7

UniProtKB/Swiss-Prot:

MED13_HUMAN :
  • Belongs to the Mediator complex subunit 13 family.
Family:
  • Belongs to the Mediator complex subunit 13 family.
genes like me logo Genes that share domains with MED13: view

Function for MED13 Gene

Molecular function for MED13 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IDA 12037571
GO:0004872 receptor activity IDA 12218053
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity NAS 10235266
genes like me logo Genes that share ontologies with MED13: view
genes like me logo Genes that share phenotypes with MED13: view

Animal Model Products

miRNA for MED13 Gene

miRTarBase miRNAs that target MED13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED13 Gene

Localization for MED13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED13 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0016592 mediator complex IDA 10198638
genes like me logo Genes that share ontologies with MED13: view

Pathways & Interactions for MED13 Gene

genes like me logo Genes that share pathways with MED13: view

Pathways by source for MED13 Gene

Gene Ontology (GO) - Biological Process for MED13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0030518 intracellular steroid hormone receptor signaling pathway IDA 11867769
genes like me logo Genes that share ontologies with MED13: view

No data available for SIGNOR curated interactions for MED13 Gene

Transcripts for MED13 Gene

Unigene Clusters for MED13 Gene

Mediator complex subunit 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED13 Gene

No ASD Table

Relevant External Links for MED13 Gene

GeneLoc Exon Structure for
MED13
ECgene alternative splicing isoforms for
MED13

Expression for MED13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED13 Gene

Protein differential expression in normal tissues from HIPED for MED13 Gene

This gene is overexpressed in Placenta (27.4), Blymphocyte (25.2), and CD8 Tcells (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MED13 Gene



Protein tissue co-expression partners for MED13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MED13 Gene:

MED13

SOURCE GeneReport for Unigene cluster for MED13 Gene:

Hs.282678

mRNA Expression by UniProt/SwissProt for MED13 Gene:

Q9UHV7-MED13_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MED13 Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MED13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED13 Gene

Orthologs for MED13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED13 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia MED13 34 35
  • 95.44 (n)
cow
(Bos Taurus)
Mammalia MED13 34 35
  • 94.99 (n)
mouse
(Mus musculus)
Mammalia Med13 34 16 35
  • 91.85 (n)
rat
(Rattus norvegicus)
Mammalia Med13 34
  • 91.54 (n)
oppossum
(Monodelphis domestica)
Mammalia MED13 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED13 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED13 34 35
  • 81.75 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 86 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia med13 34
  • 75.12 (n)
Str.10799 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10542 34
zebrafish
(Danio rerio)
Actinopterygii med13a 34 35
  • 66.71 (n)
med13b 35
  • 66 (a)
OneToMany
Dr.13644 34
fruit fly
(Drosophila melanogaster)
Insecta skd 34 35
  • 48.4 (n)
worm
(Caenorhabditis elegans)
Secernentea let-19 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2069 34
Species where no ortholog for MED13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED13 Gene

ENSEMBL:
Gene Tree for MED13 (if available)
TreeFam:
Gene Tree for MED13 (if available)

Paralogs for MED13 Gene

Paralogs for MED13 Gene

(1) SIMAP similar genes for MED13 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MED13 Gene

genes like me logo Genes that share paralogs with MED13: view

Variants for MED13 Gene

Sequence variations from dbSNP and Humsavar for MED13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs773685207 Uncertain significance 61,966,645(+) TAATC(A/G/T)ACAGG reference, synonymous-codon
rs864309592 Uncertain significance 61,962,868(-) CATAC(A/G)AAAAT reference, missense
rs140673828 Benign 61,965,208(+) TCCAC(C/T)ATTCA reference, missense
rs1000033417 -- 62,066,319(+) GCAGG(C/G/T)GCAAA upstream-variant-2KB
rs1000035834 -- 62,017,237(+) AAAAA(A/G)GCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED13 Gene

Variant ID Type Subtype PubMed ID
esv3640960 CNV loss 21293372
nsv1109098 CNV deletion 24896259
nsv112179 CNV deletion 16902084
nsv1138564 CNV deletion 24896259

Variation tolerance for MED13 Gene

Residual Variation Intolerance Score: 0.849% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED13 Gene

Human Gene Mutation Database (HGMD)
MED13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED13 Gene

Disorders for MED13 Gene

Relevant External Links for MED13

Genetic Association Database (GAD)
MED13
Human Genome Epidemiology (HuGE) Navigator
MED13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED13

No disorders were found for MED13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED13 Gene

Publications for MED13 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I. … Robledo M. (PLoS Genet. 2009) 3 46 64
  3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 64
  4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 3 4 64
  5. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PMID: 10198638) Ito M. … Roeder R.G. (Mol. Cell 1999) 3 4 64

Products for MED13 Gene

Sources for MED13 Gene

Content
Loading form....