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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED13 Gene

protein-coding   GIFtS: 56
GCID: GC17M060019

mediator complex subunit 13

(Previous name: thyroid hormone receptor associated protein 1 )
(Previous symbol: THRAP1)
 Explore 3 diseases affiliated with
MED13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MED13    

Aliases
for MED13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mediator Complex Subunit 131 2 3     ARC2502 3
THRAP11 2 3 5     DRIP2502 3
TRAP2401 2 3 5     HSPC2212
Thyroid Hormone Receptor Associated Protein 11 2     Mediator Of RNA Polymerase II Transcription Subunit 132
KIAA05931 3     Mediator Of RNA Polymerase II Transcription, Subunit 13 Homolog2
Activator-Recruited Cofactor 250 KDa Component2 3     Thyroid Hormone Receptor-Associated Protein Complex Component TRAP2402
Thyroid Hormone Receptor-Associated Protein 12 3     Thyroid Hormone Receptor-Associated Protein, 240 KDa Subunit2
Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component2 3     Trap2403
Vitamin D3 Receptor-Interacting Protein Complex Component DRIP2502 3     

External Ids:    HGNC: 224741   Entrez Gene: 99692   Ensembl: ENSG000001085107   OMIM: 6038085   UniProtKB: Q9UHV73   

Export aliases for MED13 gene to outside databases

Previous GC identifers: GC17M057374 GC17M055388


Summaries
for MED13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MED13:
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional
coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited
by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA
polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is
proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by
mediator. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors




Genomic Views
for MED13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED13 gene promoter:
         AML1a   ATF-2   Lmo2   E47   Meis-1b   CRE-BP1   Pax-3   Meis-1a   RSRFC4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MED13 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q22-q23

MED13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M060019:  view genomic region     (about GC identifiers)

Start:
 60,019,966 bp from pter      End:
 60,142,643 bp from pter
Size:
 122,678 bases      Orientation:
 minus strand

Proteins
for MED13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 13  
Size: 2174 amino acids; 239297 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in
supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct
subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus
Sequence caution: Sequence=AAD22032.1; Type=Frameshift; Positions=Several;
Secondary accessions: B2RU05 O60334

Explore the universe of human proteins at neXtProt for MED13: NX_Q9UHV7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHV7

    • MED13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005112.2  
    ENSEMBL proteins: 
     ENSP00000380888   ENSP00000464131  
    Reactome Protein details: Q9UHV7
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MED13 
    GenScript Custom Purified and Recombinant Proteins Services for MED13
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED13

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10235267
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IDA12037571


    MED13 for ontologies           About GeneDecksing



    MED13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED13 
    GenScript Custom Superior Antibodies Services for MED13
    Novus Biologicals MED13 Antibodies
    Search for Antibodies for MED13 at Abcam  
    Uscn Antibodies for MED13
    Search ThermoFisher Antibodies for MED13

    Assay Products for MED13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED13
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MED13

    Protein Domains /
    Families
    for MED13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MED13 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021643 Mediator_Med13_N_met/fun
     IPR009401 Mediator_Med13

    Graphical View of Domain Structure for InterPro Entry Q9UHV7

    ProtoNet protein and cluster: Q9UHV7

    UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7
    Similarity: Belongs to the Mediator complex subunit 13 family


    Function
    for MED13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

    miRNA
    Products:            		miRTarBase miRNAs that target MED13:
    hsa-mir-208a (MIRT003912)

    OriGene 3'-UTR Clone: MED13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED13
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate MED13 (see all 97):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-1321 hsa-miR-3607-3p hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-134
    SwitchGear 3'UTR luciferase reporter plasmid: MED13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED13 (see all 7)
    OriGene shRNA RFP: MED13
    OriGene siRNA: MED13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MED13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED13 (NM_005121)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED13 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MED13
    Search LifeMap BioReagents cell lines for MED13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003712transcription cofactor activity IDA12218053
    GO:0003713transcription coactivator activity IDA12037571
    GO:0004872receptor activity IDA12218053
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity NAS10235266


    MED13 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MED13:
     Decreased POU5F1-GFP protein e 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Med13):
     adipose tissue  cardiovascular system  growth/size  homeostasis/metabolism  liver/biliary system 

    MED13 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MED13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2HIV Infection
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    3Transcriptional Regulation of White Adipocyte Differentiation
    		Transcriptional Regulation of White Adipocyte Differentiation1.00
    4Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MED13
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for MED13
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4        Reactome Pathways for MED13
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Gene Expression



    MED13 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/112 Interacting proteins for MED13 (Q9UHV72, 3 ENSP000003808884) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156482, 3, ENSP000003006514MINT-6744331 I2D: score=1 STRING: ENSP00000300651
    MED12Q930742, 3, ENSP000003631934MINT-6744331 MINT-7010915 I2D: score=3 STRING: ENSP00000363193
    TRRAPQ9Y4A52, 3, ENSP000003477334MINT-6744331 I2D: score=1 STRING: ENSP00000347733
    MED23Q9ULK42, 3, ENSP000003570474MINT-6744331 I2D: score=3 STRING: ENSP00000357047
    MED13LQ71F563, ENSP000002819284I2D: score=2 STRING: ENSP00000281928
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030518intracellular steroid hormone receptor signaling pathway IDA11867769
    GO:0030521androgen receptor signaling pathway IDA12218053
    GO:0045893positive regulation of transcription, DNA-dependent IDA10198638


    MED13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MED13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED13
    Search CenterWatch for drugs/clinical trials and news about MED13 

    Transcripts
    for MED13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MED13 gene: 
    NM_005121.2  

    Unigene Cluster for MED13:

    Mediator complex subunit 13
    Hs.282678  [show with all ESTs]
    Unigene Representative Sequence: NM_005121
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397786(uc002izo.3) ENST00000582786 ENST00000583958(uc002izp.3)
    ENST00000581994 ENST00000578132 ENST00000580896

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MED13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED13
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate MED13 (see all 97):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-1321 hsa-miR-3607-3p hsa-miR-300 hsa-miR-485-3p hsa-miR-128 hsa-miR-134
    SwitchGear 3'UTR luciferase reporter plasmid: MED13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED13 (see all 7)
    OriGene shRNA RFP: MED13
    OriGene siRNA: MED13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED13 (NM_005121)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED13

    Additional cDNA sequence: 

    AB011165.2 AF117754.1 AF151055.1 AK054894.1 AK124099.1 BC044258.1 BC140891.1 

    12 DOTS entries:

    DT.452326  DT.100785751  DT.408817  DT.75144131  DT.100785756  DT.120956451  DT.101977058  DT.86858782 
    DT.91748798  DT.91748811  DT.99953036  DT.91748799 

    24/281 AceView cDNA sequences (see all 281):

    BI837972 AI248464 BQ716876 AW057608 AI803003 AI093413 AW075469 AA927599 
    AI379941 BF594547 F29901 AA480860 AA665822 AW129532 AB011165 AA256007 
    AI376624 H38035 AA343200 AA243325 N40577 AA372209 AI274781 BM979342 

    GeneLoc Exon Structure


    Expression
    for MED13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCCTTCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MED13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MED13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED13

    SOURCE GeneReport for Unigene cluster: Hs.282678

    UniProtKB/Swiss-Prot: MED13_HUMAN, Q9UHV7
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including MED13: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED13
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED13

    Orthologs
    for MED13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MED13 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MED131 mediator complex subunit 13 82.07(n)
    88.35(a)    		   417639  XM_415884.3  XP_415884.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 91(a)
    64(a)
    		 1 ↔ 1
    possible ortholog
    		 GL345053.1(1072-9289)
    GL343470.1(18022-139110)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.105422 Xenopus laevis transcribed sequence with strong similarity more 88.84(n)    CA982815.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.136442 Transcribed sequence with moderate similarity to protein more 74.68(n)    CD594740.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta skd6
    		 skuld
    		 23(a)
    		 1 → many
    		 3L(20985914-21020534)
    worm
    (Caenorhabditis elegans)    		 Secernentea let-196
    		 Mediator of RNA polymerase II transcription subuni...
    		 17(a)
    		 1 → many
    		 II(8770920-8781966)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GCT6
    		 RNA polymerase II transcription mediator
    		 13(a)
    		 1 → many
    		 1(20637380-20648434)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 expressed protein
    		 11(a)
    		 1 → many
    		 5(21880486-21897228)


    ENSEMBL Gene Tree for MED13 (if available)
    TreeFam Gene Tree for MED13 (if available) 

    Paralogs
    for MED13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED13 gene
    MED13L2  
    1 SIMAP similar gene for MED13 using alignment to 2 protein entries:     MED13_HUMAN (see all proteins):
    MED13L

    MED13 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MED13
    PGOHUM00000235428 PGOHUM00000233965


    Genomic Variants
    for MED13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1915 NCBI SNPs in MED13 are shown (see all 1915)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1480375671,2
    		C,--60019753(+) ACAAG-/GAATT 
                GGTAG     		1 -- ds50010--------
    rs1855156401,2
    		--60019754(+) CAAGGA/CATTGG 1 -- ds50010--------
    rs1435955191,2
    		--60019927(+) CAAATG/TTAATA 1 -- ds50010--------
    rs1900383151,2
    		--60020023(+) TTTTTG/TTTTTT 1 -- ut310--------
    rs1471891111,2
    		--60020081(+) TCAGTA/GTTATG 1 -- ut310--------
    rs757292501,2
    		--60020093(+) CATTCA/GGCAGC 1 -- ut310--------
    rs41981,2
    		F--60020138(+) TTAAAAAG/-AAAAG 2 -- ut314Minor allele frequency- -:0.12EU NA EA 342
    rs1394412471,2
    		C,--60020138(+) TTAAA-/AAGAAAAG 1 -- ut310--------
    rs2020505431,2
    		C--60020140(+) AAAAAA/GANNNN 1 -- ut310--------
    rs1151218691,2
    		F,--60020324(+) AAGATG/ATTTTA 1 -- ut311Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for MED13 (60019966 - 60142643 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MED13
         1 Indel: 11890
    Human Gene Mutation Database (HGMD): MED13

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED13
    DNA2.0 Custom Variant and Variant Library Synthesis for MED13

    Disorders / Diseases
    for MED13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MED13 for disorders           About GeneDecksing

    OMIM gene information: 603808    OMIM disorders: --

    3 diseases for MED13:    About MalaCards
    thyroiditis    blindness    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: MED13 (3 documents)

    Export disorders for MED13 gene to outside databases

    Publications
    for MED13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED13 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with MED13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
    2. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S....Conaway R.C. (2004)
    3. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PubMed id 10198638)1, 2 Ito M.... Roeder R.G. (1999)
    4. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. (PubMed id 10235266)1, 2 Rachez C.... Freedman L.P. (1999)
    5. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PubMed id 10235267)1, 2 Naeaer A.M....Tjian R. (1999)
    6. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)

    External Searches for MED13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MED13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9969 HGNC: 22474 AceView: THRAP1 Ensembl:ENSG00000108510 euGenes: HUgn9969
    ECgene: MED13 H-InvDB: MED13

    Other Databases showing MED13 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0593

    Specialized Databases showing MED13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED13 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MED13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MED13 gene:
    Search GeneIP for patents involving MED13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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     Regulatory tfbs in MED13 promoter
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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