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Aliases for MED12L Gene

Aliases for MED12L Gene

  • Mediator Complex Subunit 12-Like 2 3
  • Trinucleotide Repeat-Containing Gene 11 Protein-Like 3 4
  • Thyroid Hormone Receptor-Associated-Like Protein 3 4
  • TRALPUSH 3 4
  • KIAA1635 4 6
  • TNRC11L 3 4
  • NOPAR 3 6
  • TRALP 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 12 Homolog (S. Cerevisiae)-Like 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 12 Homolog-Like 3
  • Mediator Of RNA Polymerase II Transcription Subunit 12-Like Protein 3
  • Mediator Complex Subunit 12-Like Protein 4
  • No Opposite Paired Repeat Protein 3

External Ids for MED12L Gene

Previous GeneCards Identifiers for MED12L Gene

  • GC03P152287
  • GC03P150803
  • GC03P148177

Summaries for MED12L Gene

Entrez Gene Summary for MED12L Gene

  • The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]

GeneCards Summary for MED12L Gene

MED12L (Mediator Complex Subunit 12-Like) is a Protein Coding gene. Among its related pathways are Thyroid hormone signaling pathway. GO annotations related to this gene include beta-catenin binding and RNA polymerase II transcription cofactor activity. An important paralog of this gene is MED12.

UniProtKB/Swiss-Prot for MED12L Gene

  • May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED12L Gene

Genomics for MED12L Gene

Regulatory Elements for MED12L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED12L Gene

Start:
151,085,697 bp from pter
End:
151,437,072 bp from pter
Size:
351,376 bases
Orientation:
Plus strand

Genomic View for MED12L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED12L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED12L Gene

Proteins for MED12L Gene

  • Protein details for MED12L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YW9-MD12L_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 12-like protein
    Protein Accession:
    Q86YW9
    Secondary Accessions:
    • Q96PC7
    • Q96PC8
    • Q9H9M5
    • Q9HCD7
    • Q9UI69

    Protein attributes for MED12L Gene

    Size:
    2145 amino acids
    Molecular mass:
    240120 Da
    Quaternary structure:
    • May be a component of the Mediator complex, which is known to be composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
    SequenceCaution:
    • Sequence=AAF24035.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part and potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14198.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED12L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED12L Gene

Proteomics data for MED12L Gene at MOPED

Post-translational modifications for MED12L Gene

  • Ubiquitination at Lys1150 and Lys1851
  • Modification sites at PhosphoSitePlus

Other Protein References for MED12L Gene

No data available for DME Specific Peptides for MED12L Gene

Domains for MED12L Gene

Protein Domains for MED12L Gene

Suggested Antigen Peptide Sequences for MED12L Gene

Graphical View of Domain Structure for InterPro Entry

Q86YW9

UniProtKB/Swiss-Prot:

MD12L_HUMAN :
  • Q86YW9
Family:
  • Belongs to the Mediator complex subunit 12 family.
genes like me logo Genes that share domains with MED12L: view

No data available for Gene Families for MED12L Gene

Function for MED12L Gene

Molecular function for MED12L Gene

UniProtKB/Swiss-Prot Function: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Gene Ontology (GO) - Molecular Function for MED12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IBA --
GO:0008013 beta-catenin binding IEA --
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with MED12L: view
genes like me logo Genes that share phenotypes with MED12L: view

Animal Model Products

CRISPR Products

miRNA for MED12L Gene

miRTarBase miRNAs that target MED12L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED12L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED12L Gene

Localization for MED12L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED12L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED12L Gene COMPARTMENTS Subcellular localization image for MED12L gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MED12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IBA --
genes like me logo Genes that share ontologies with MED12L: view

Pathways for MED12L Gene

genes like me logo Genes that share pathways with MED12L: view

Pathways by source for MED12L Gene

1 KEGG pathway for MED12L Gene

Gene Ontology (GO) - Biological Process for MED12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with MED12L: view

Transcripts for MED12L Gene

Unigene Clusters for MED12L Gene

Mediator complex subunit 12-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED12L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MED12L
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED12L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for MED12L Gene

GeneLoc Exon Structure for
MED12L
ECgene alternative splicing isoforms for
MED12L

Expression for MED12L Gene

mRNA expression in normal human tissues for MED12L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED12L Gene

SOURCE GeneReport for Unigene cluster for MED12L Gene Hs.744234

genes like me logo Genes that share expressions with MED12L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED12L Gene

Orthologs for MED12L Gene

This gene was present in the common ancestor of animals.

Orthologs for MED12L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED12L 35
  • 99.66 (n)
  • 99.77 (a)
MED12L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED12L 35
  • 91.59 (n)
  • 96.97 (a)
MED12L 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED12L 35
  • 92.64 (n)
  • 97.72 (a)
MED12L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med12l 35
  • 88.72 (n)
  • 94.81 (a)
Med12l 16
Med12l 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED12L 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves MED12L 35
  • 78.91 (n)
  • 85.45 (a)
MED12L 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED12L 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002523 35
  • 51.4 (n)
  • 48.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta kto 35
  • 50.62 (n)
  • 46.45 (a)
kto 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-22 36
  • 10 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.569 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for MED12L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MED12L Gene

ENSEMBL:
Gene Tree for MED12L (if available)
TreeFam:
Gene Tree for MED12L (if available)

Paralogs for MED12L Gene

Paralogs for MED12L Gene

Selected SIMAP similar genes for MED12L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MED12L: view

Variants for MED12L Gene

Sequence variations from dbSNP and Humsavar for MED12L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs17504 -- 151,398,246(+) GCTAC(A/G)GTTGT intron-variant
rs722133 -- 151,174,706(+) ttttt(A/T)aattt intron-variant
rs747205 -- 151,145,017(+) GCCCT(A/C/T)GCTCT intron-variant
rs765281 -- 151,398,203(-) ACTGG(A/G)AGGGA intron-variant
rs766201 -- 151,324,269(+) attca(A/G)gaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED12L Gene

Variant ID Type Subtype PubMed ID
nsv829756 CNV Gain+Loss 17160897
dgv1520e1 CNV Complex 17122850
nsv877648 CNV Gain 21882294
esv268677 CNV Insertion 20981092
nsv10341 CNV Loss 18304495
esv2673993 CNV Deletion 23128226
esv268436 CNV Insertion 20981092
esv2726052 CNV Deletion 23290073
esv2726053 CNV Deletion 23290073
esv2726054 CNV Deletion 23290073
esv2726055 CNV Deletion 23290073
nsv829757 CNV Loss 17160897
esv2726056 CNV Deletion 23290073
esv2400186 CNV Deletion 18987734
esv2726057 CNV Deletion 23290073
esv1169457 CNV Deletion 17803354
esv2726058 CNV Deletion 23290073
nsv4063 CNV Insertion 18451855
esv999811 CNV Insertion 20482838
nsv508960 CNV Insertion 20534489
nsv877649 CNV Loss 21882294
esv270416 CNV Insertion 20981092
esv273729 CNV Insertion 20981092

Relevant External Links for MED12L Gene

HapMap Linkage Disequilibrium report
MED12L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED12L Gene

Disorders for MED12L Gene

Relevant External Links for MED12L

Genetic Association Database (GAD)
MED12L
Human Genome Epidemiology (HuGE) Navigator
MED12L
genes like me logo Genes that share disorders with MED12L: view

No data available for UniProtKB/Swiss-Prot for MED12L Gene

Publications for MED12L Gene

  1. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PMID: 11524702) Joensuu T. … Sankila E.-M. (Am. J. Hum. Genet. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for MED12L Gene

Sources for MED12L Gene

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