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Aliases for MED12L Gene

Aliases for MED12L Gene

  • Mediator Complex Subunit 12 Like 2 3 5
  • Trinucleotide Repeat-Containing Gene 11 Protein-Like 3 4
  • Thyroid Hormone Receptor-Associated-Like Protein 3 4
  • Mediator Complex Subunit 12-Like 2 3
  • TRALPUSH 3 4
  • TNRC11L 3 4
  • TRALP 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 12 Homolog (S. Cerevisiae)-Like 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 12 Homolog-Like 3
  • Mediator Complex Subunit 12-Like Protein 4
  • No Opposite Paired Repeat Protein 3
  • KIAA1635 4
  • NOPAR 3

External Ids for MED12L Gene

Previous GeneCards Identifiers for MED12L Gene

  • GC03P152287
  • GC03P150803
  • GC03P148177

Summaries for MED12L Gene

Entrez Gene Summary for MED12L Gene

  • The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]

GeneCards Summary for MED12L Gene

MED12L (Mediator Complex Subunit 12 Like) is a Protein Coding gene. Among its related pathways are Thyroid hormone signaling pathway. GO annotations related to this gene include transcription factor binding and RNA polymerase II transcription cofactor activity. An important paralog of this gene is MED12.

UniProtKB/Swiss-Prot for MED12L Gene

  • May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED12L Gene

Genomics for MED12L Gene

Regulatory Elements for MED12L Gene

Enhancers for MED12L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MED12L on UCSC Golden Path with GeneCards custom track

Promoters for MED12L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED12L on UCSC Golden Path with GeneCards custom track

Genomic Location for MED12L Gene

Chromosome:
3
Start:
151,085,665 bp from pter
End:
151,437,072 bp from pter
Size:
351,408 bases
Orientation:
Plus strand

Genomic View for MED12L Gene

Genes around MED12L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED12L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED12L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED12L Gene

Proteins for MED12L Gene

  • Protein details for MED12L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YW9-MD12L_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 12-like protein
    Protein Accession:
    Q86YW9
    Secondary Accessions:
    • Q96PC7
    • Q96PC8
    • Q9H9M5
    • Q9HCD7
    • Q9UI69

    Protein attributes for MED12L Gene

    Size:
    2145 amino acids
    Molecular mass:
    240120 Da
    Quaternary structure:
    • May be a component of the Mediator complex, which is known to be composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
    SequenceCaution:
    • Sequence=AAF24035.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part and potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14198.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED12L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED12L Gene

Proteomics data for MED12L Gene at MOPED

Post-translational modifications for MED12L Gene

  • Ubiquitination at Lys 1150 and Lys 1851
  • Modification sites at PhosphoSitePlus

Other Protein References for MED12L Gene

No data available for DME Specific Peptides for MED12L Gene

Domains & Families for MED12L Gene

Gene Families for MED12L Gene

Protein Domains for MED12L Gene

Suggested Antigen Peptide Sequences for MED12L Gene

Graphical View of Domain Structure for InterPro Entry

Q86YW9

UniProtKB/Swiss-Prot:

MD12L_HUMAN :
  • Belongs to the Mediator complex subunit 12 family.
Family:
  • Belongs to the Mediator complex subunit 12 family.
genes like me logo Genes that share domains with MED12L: view

Function for MED12L Gene

Molecular function for MED12L Gene

UniProtKB/Swiss-Prot Function:
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
genes like me logo Genes that share phenotypes with MED12L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED12L Gene

Localization for MED12L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED12L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED12L Gene COMPARTMENTS Subcellular localization image for MED12L gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for MED12L Gene

Pathways & Interactions for MED12L Gene

genes like me logo Genes that share pathways with MED12L: view

Pathways by source for MED12L Gene

1 KEGG pathway for MED12L Gene

Gene Ontology (GO) - Biological Process for MED12L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with MED12L: view

No data available for SIGNOR curated interactions for MED12L Gene

Drugs & Compounds for MED12L Gene

No Compound Related Data Available

Transcripts for MED12L Gene

Unigene Clusters for MED12L Gene

Mediator complex subunit 12-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED12L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for MED12L Gene

GeneLoc Exon Structure for
MED12L
ECgene alternative splicing isoforms for
MED12L

Expression for MED12L Gene

mRNA expression in normal human tissues for MED12L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED12L Gene

This gene is overexpressed in Plasma (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED12L Gene



SOURCE GeneReport for Unigene cluster for MED12L Gene Hs.744234

genes like me logo Genes that share expression patterns with MED12L: view

Protein tissue co-expression partners for MED12L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED12L Gene

Orthologs for MED12L Gene

This gene was present in the common ancestor of animals.

Orthologs for MED12L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED12L 35
  • 91.59 (n)
  • 96.97 (a)
MED12L 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED12L 35
  • 92.64 (n)
  • 97.72 (a)
MED12L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med12l 35
  • 88.72 (n)
  • 94.81 (a)
Med12l 16
Med12l 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED12L 35
  • 99.66 (n)
  • 99.77 (a)
MED12L 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED12L 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves MED12L 35
  • 78.91 (n)
  • 85.45 (a)
MED12L 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED12L 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002523 35
  • 51.4 (n)
  • 48.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta kto 35
  • 50.62 (n)
  • 46.45 (a)
kto 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-22 36
  • 10 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.569 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for MED12L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MED12L Gene

ENSEMBL:
Gene Tree for MED12L (if available)
TreeFam:
Gene Tree for MED12L (if available)

Paralogs for MED12L Gene

Paralogs for MED12L Gene

(2) SIMAP similar genes for MED12L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MED12L: view

Variants for MED12L Gene

Sequence variations from dbSNP and Humsavar for MED12L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17290219 - 151,163,987(+) GCTGC(A/C)GGTGG reference, missense
rs3108728 - 151,165,878(-) AACTT(C/T)CAACG reference, missense
VAR_037649 -
VAR_037650 -
rs2276761 - 151,387,919(+) GGACC(A/G)AAGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MED12L Gene

Variant ID Type Subtype PubMed ID
nsv829756 CNV Gain+Loss 17160897
dgv1520e1 CNV Complex 17122850
nsv877648 CNV Gain 21882294
esv268677 CNV Insertion 20981092
nsv10341 CNV Loss 18304495
esv2673993 CNV Deletion 23128226
esv268436 CNV Insertion 20981092
esv2726052 CNV Deletion 23290073
esv2726053 CNV Deletion 23290073
esv2726054 CNV Deletion 23290073
esv2726055 CNV Deletion 23290073
nsv829757 CNV Loss 17160897
esv2726056 CNV Deletion 23290073
esv2400186 CNV Deletion 18987734
esv2726057 CNV Deletion 23290073
esv1169457 CNV Deletion 17803354
esv2726058 CNV Deletion 23290073
nsv4063 CNV Insertion 18451855
esv999811 CNV Insertion 20482838
nsv508960 CNV Insertion 20534489
nsv877649 CNV Loss 21882294
esv270416 CNV Insertion 20981092
esv273729 CNV Insertion 20981092

Variation tolerance for MED12L Gene

Residual Variation Intolerance Score: 0.283% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED12L Gene

HapMap Linkage Disequilibrium report
MED12L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED12L Gene

Disorders for MED12L Gene

Relevant External Links for MED12L

Genetic Association Database (GAD)
MED12L
Human Genome Epidemiology (HuGE) Navigator
MED12L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED12L

No disorders were found for MED12L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED12L Gene

Publications for MED12L Gene

  1. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PMID: 11524702) Joensuu T. … Sankila E.-M. (Am. J. Hum. Genet. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai D.C. … Hagoort P. (Genes Brain Behav. 2014) 3
  5. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PMID: 24023788) Ong B.A. … Hakonarson H. (PLoS ONE 2013) 3

Products for MED12L Gene

Sources for MED12L Gene

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