Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MED12L Gene

protein-coding   GIFtS: 52
GCID: GC03P150803

Mediator Complex Subunit 12-Like

(Previous names: mediator of RNA polymerase II transcription, subunit 12...)
  See MED12L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mediator Complex Subunit 12-Like1 2     KIAA16353 5
Thyroid Hormone Receptor-Associated-Like Protein2 3     Mediator Of RNA Polymerase II Transcription, Subunit 12 Homolog (S.
Cerevisiae)-Like1
Trinucleotide Repeat-Containing Gene 11 Protein-Like2 3     Mediator Of RNA Polymerase II Transcription Subunit 12-Like Protein2
TNRC11L2 3     Mediator Of RNA Polymerase II Transcription, Subunit 12 Homolog-Like2
TRALP2 3     No Opposite Paired Repeat Protein2
TRALPUSH2 3     Mediator Complex Subunit 12-Like Protein3
NOPAR2 5     

External Ids:    HGNC: 160501   Entrez Gene: 1169312   Ensembl: ENSG000001448937   OMIM: 6113185   UniProtKB: Q86YW93   

Export aliases for MED12L gene to outside databases

Previous GC identifers: GC03P152287 GC03P148177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MED12L Gene:
The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional
coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific
transcriptional activators with the basal transcription machinery. (provided by RefSeq, May 2010)

GeneCards Summary for MED12L Gene:
MED12L (mediator complex subunit 12-like) is a protein-coding gene. Diseases associated with MED12L include usher syndrome type 3. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and beta-catenin binding. An important paralog of this gene is MED12.

UniProtKB/Swiss-Prot: MD12L_HUMAN, Q86YW9
Function: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of
nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from
gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited
to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a
functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the MED12L gene promoter:
         USF1   Elk-1   Pax-5   USF2   USF-1:USF-2   LCR-F1   Evi-1   CP2   Zic1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED12L promoter sequence
   Search Chromatin IP Primers for MED12L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED12L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

MED12L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED12L gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P150803:  view genomic region     (about GC identifiers)

Start:
150,803,484 bp from pter      End:
151,154,860 bp from pter
Size:
351,377 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MD12L_HUMAN, Q86YW9 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 12-like protein  
Size: 2145 amino acids; 240120 Da
Subunit: May be a component of the Mediator complex, which is known to be composed of MED1, MED4, MED6, MED7,
MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22,
MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and
CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active
than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the
Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and
TRAP (By similarity)
Sequence caution: Sequence=AAF24035.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part and potential poly-A sequence; Sequence=BAB14198.1; Type=Erroneous
initiation;
Secondary accessions: Q96PC7 Q96PC8 Q9H9M5 Q9HCD7 Q9UI69
Alternative splicing: 4 isoforms:  Q86YW9-1   Q86YW9-2   Q86YW9-3   Q86YW9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MED12L: NX_Q86YW9

Explore proteomics data for MED12L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1150, Lys1851
  • Modification sites at PhosphoSitePlus

  • See MED12L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443728.3  
    ENSEMBL proteins: 
     ENSP00000403308   ENSP00000310760   ENSP00000417235   ENSP00000273432   ENSP00000417420  

    MED12L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MED12L
    GenScript Custom Purified and Recombinant Proteins Services for MED12L
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED12L

     
    Search eBioscience for Proteins for MED12L 

    MED12L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED12L
    Novus Biologicals MED12L Antibody
    Abcam antibodies for MED12L
    Cloud-Clone Corp. Antibodies for MED12L
    Search ThermoFisher Antibodies for MED12L
    Search LSBio for Antibodies for MED12L

    MED12L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED12L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED12L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED12L
    Cloud-Clone Corp. CLIAs for MED12L
    Search eBioscience for ELISAs for MED12L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR021989 Mediator_Med12_catenin-bd
     IPR019035 Mediator_Med12
     IPR021990 Mediator_Med12_LCEWAV

    Graphical View of Domain Structure for InterPro Entry Q86YW9

    ProtoNet protein and cluster: Q86YW9

    UniProtKB/Swiss-Prot: MD12L_HUMAN, Q86YW9
    Similarity: Belongs to the Mediator complex subunit 12 family


    Find genes that share domains with MED12L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MD12L_HUMAN, Q86YW9
    Function: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of
    nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from
    gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited
    to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a
    functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
    GO:0008013beta-catenin binding IEA--
    GO:0008134transcription factor binding IEA--
         
    Find genes that share ontologies with MED12L           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MED12L:
     Decreased number of cells in m  Increased S DNA content  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED12L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED12L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED12L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED12L

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED12L:
    hsa-mir-93-5p (MIRT028147), hsa-mir-484 (MIRT042329)

    Block miRNA regulation of human, mouse, rat MED12L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED12L (see all 134):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidMED12L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED12L
    Predesigned siRNA for gene silencing in human, mouse, rat MED12L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED12L

    Clone
    Products:
         
    OriGene clones in human, mouse for MED12L (see all 5)
    OriGene ORF clones in mouse, rat for MED12L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED12L (NM_053002)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED12L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED12L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED12L
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED12L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED12L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MD12L_HUMAN, Q86YW9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016592mediator complex IEA--

    Find genes that share ontologies with MED12L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MED12L About    
    See pathways by source

    SuperPathContained pathways About
    1Thyroid hormone signaling pathway
    Thyroid hormone signaling pathway


    Find genes that share SuperPaths with MED12L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MED12L):
        Thyroid hormone signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED12L
    Interactions:

        Search GeneGlobe Interaction Network for MED12L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED12L (Q86YW92, 3 ENSP000004172354) via UniProtKB, MINT, STRING, and/or I2D (see all 593)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    MED13LQ71F563, ENSP000002819284I2D: score=1 STRING: ENSP00000281928
    MED31Q9Y3C73, ENSP000002257284I2D: score=1 STRING: ENSP00000225728
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CDK8P493363, ENSP000003709384I2D: score=2 STRING: ENSP00000370938
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with MED12L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED12L (MD12L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MED12L gene: 
    NM_053002.4  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469768 ENST00000422248(uc003eym.1 uc003eyo.3) ENST00000309237(uc003eyn.3)
    ENST00000474524(uc003eyp.3 uc011bnz.2) ENST00000273432(uc003eyy.1)
    ENST00000480026 ENST00000491549 ENST00000468305 ENST00000488092
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED12L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED12L (see all 134):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidMED12L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED12L
    Predesigned siRNA for gene silencing in human, mouse, rat MED12L
    Clone
    Products:
         
    OriGene clones in human, mouse for MED12L (see all 5)
    OriGene ORF clones in mouse, rat for MED12L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED12L (NM_053002)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED12L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED12L
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MED12L
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MED12L
      QuantiTect SYBR Green Assays in human, mouse, rat MED12L
      QuantiFast Probe-based Assays in human, mouse, rat MED12L

    Selected AceView cDNA sequences (see all 35):

    AI018271 AF388365 AA292658 AK128165 AU132578 AU125717 AK022714 AF388364 
    BX956402 AF399708 BX484379 NM_053002 AF090917 AU154084 AA931311 BG620396 
    AB046855 AA428945 AA284420 AA827655 BX108326 AF087980 BF970855 BQ429110 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MED12L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                                                              
    SP2:                                                                                -                                             
    SP3:                                                                                                                              
    SP4:                                                                                            -                                 


    ECgene alternative splicing isoforms for MED12L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MED12L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTATGGCTG
    MED12L Expression
    About this image


    MED12L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    MED12L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED12L Protein Expression
        Custom PCR Arrays for MED12L
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MED12L
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MED12L
    QuantiTect SYBR Green Assays in human, mouse, rat MED12L
    QuantiFast Probe-based Assays in human, mouse, rat MED12L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED12L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MED12L gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med12l1 , 5 mediator of RNA polymerase II transcription, subunit more5
    mediator complex subunit 12-like1
    88.72(n)1
    94.81(a)1
      3 (28.89 cM)5
    3296501  NM_177855.31  NP_808523.21 
     590069785 
    chicken
    (Gallus gallus)
    Aves MED12L1 mediator complex subunit 12-like 78.91(n)
    85.45(a)
      425036  XM_422838.4  XP_422838.4 
    lizard
    (Anolis carolinensis)
    Reptilia MED12L6
    mediator complex subunit 12-like
    78(a)
    1 ↔ 1
    3(17993620-18157698)
    fruit fly
    (Drosophila melanogaster)
    Insecta kto1 kohtalo 50.62(n)
    46.45(a)
      44830  NM_080047.2  NP_524786.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-226
    Protein DPY-22 (dpy-22) mRNA, complete cds
    10(a)
    1 → many
    X(9810231-9822273) WBGene00001081


    ENSEMBL Gene Tree for MED12L (if available)
    TreeFam Gene Tree for MED12L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MED12L gene
    MED122  
    2 SIMAP similar genes for MED12L using alignment to 4 protein entries:     MD12L_HUMAN (see all proteins):
    TNRC11    MED12

    Find genes that share paralogs with MED12L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MED12L (see all 7377)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502967781,2
    Cuntested1150897849(+) AAATCG/AGCTGT 1 -- int11Minor allele frequency- A:0.00NA 4542
    rs1438295051,2
    Cuntested1151037383(+) AAAAAA/C/TAATAA 1 -- int10--------
    rs105779081,2
    C--148229044(+) TAGTC-/CTTCATTG 1 -- int10--------
    rs355768281,2
    C--148229045(+) AGTCCTTC/-ATTGT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1413538891,2
    C--148242897(+) TTTTT-/TTTTT 
            
    GGAGA
    1 -- int10--------
    rs58535081,2
    C--148293806(+) GATGC-/TTTTTTTT 1 -- cds1 trp30--------
    rs789157071,2
    C--148314959(+) TATCT-/TTGGAG 1 -- int10--------
    rs667005421,2
    C--148326547(+) AATAAATAA/-  
            
    GTAAA
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs114532941,2
    C--148344762(+) TTTTT-/TGTTAA 1 -- int1 trp30--------
    rs1462509921,2
    C--148373051(+) TTTTT-/TGTTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MED12L (150803484 - 151053484 bp, first 250kb of MED12L)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MED12L (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726057CNV Deletion23290073
    esv2400186CNV Deletion18987734
    esv2726058CNV Deletion23290073
    esv2726056CNV Deletion23290073
    esv1169457CNV Deletion17803354
    esv2673993CNV Deletion23128226
    esv2726054CNV Deletion23290073
    esv2726053CNV Deletion23290073
    esv2726055CNV Deletion23290073
    esv2726052CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED12L
    DNA2.0 Custom Variant and Variant Library Synthesis for MED12L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611318    OMIM disorders: --

    1 disease for MED12L:    
    About MalaCards
    usher syndrome type 3


    Find genes that share disorders with MED12L           About GenesLikeMe

    Genetic Association Database (GAD): MED12L
    Human Genome Epidemiology (HuGE) Navigator: MED12L (4 documents)

    Export disorders for MED12L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MED12L gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MED12L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PubMed id 11524702)1, 2, 3 Joensuu T.... Sankila E.-M. (Am. J. Hum. Genet. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PubMed id 24023788)1 Ong B.A....Hakonarson H. (PLoS ONE 2013)
    7. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. (PubMed id 19762545)1 van de Wijngaart D.J....Jenster G. (Mol. Endocrinol. 2009)
    10. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. (PubMed id 18463370)4 Maris J.M....Hakonarson H. (N. Engl. J. Med. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 116931 HGNC: 16050 AceView: TRALPUSH Ensembl:ENSG00000144893 euGenes: HUgn116931
    ECgene: MED12L Kegg: 116931 H-InvDB: MED12L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1635

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MED12L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MED12L gene:
    Search GeneIP for patents involving MED12L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MED12L  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MED12L  
     OriGene qSTAR qPCR primer pairs in human, mouse for MED12L   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MED12L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MED12L   OriGene Custom Protein Services for MED12L  

     
     
     Block miRNA regulation of human, mouse, rat MED12L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MED12L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED12L Predesigned siRNA for gene silencing in human, mouse, rat MED12L
     QuantiFast Probe-based Assays in human, mouse, rat MED12L QuantiTect SYBR Green Assays in human, mouse, rat MED12L
     Custom PCR Arrays for MED12L Search Chromatin IP Primers for MED12L
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MED12L  Search GeneGlobe Interaction Network for MED12L
     Regulatory tfbs in MED12L promoter
     GenScript Custom Purified and Recombinant Proteins Services for MED12L GenScript cDNA clones with any tag delivered in your preferred vector for MED12L
     GenScript Custom Assay Services for MED12L GenScript Custom overexpressing Cell Line Services for MED12L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MED12L (MD12L)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MED12L antibodies
     Antibodies for MED12L
     See all of Abcam's Antibodies, Kits and Proteins for MED12L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MED12L
     Antibodies for MED12L
     ELISAs for MED12L
     CLIAs for MED12L



     Browse ESI BIO Cell Lines and PureStem Progenitors for MED12L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED12L
     SwitchGear 3'UTR luciferase reporter plasmids for MED12L
     SwitchGear Promoter luciferase reporter plasmids for MED12L
     Search ThermoFisher Antibodies for MED12L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED12L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED12L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED12L
     Search LSBio for Antibodies for MED12L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MED12L
      Search eBioscience for proteins for MED12L
      Search eBioscience for elisas for MED12L
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MED12L gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4