MED11 Gene
protein-coding GIFtS: 45
GCID: GC17P004634
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mediator complex subunit 11(Previous names: mediator of RNA polymerase II transcription, subunit 11...)
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Aliases
for MED11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mediator Complex Subunit 111 2 3 | | HSPC2961 | | MGC883871 | | Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog (S. Cerevisiae)1 | | Mediator Of RNA Polymerase II Transcription Subunit 112 | | Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog2 |
Export aliases for MED11 gene to outside databasesPrevious GC identifers: GC17P004582 GC17P004523 |
Summaries
for MED11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MED11:
MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activatetranscription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)
UniProtKB/Swiss-Prot: MED11_HUMAN, Q9P086Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors
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Genomic Views
for MED11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MED11 gene promoter:
COUP-TF1 COUP-TF COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MED11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2MED11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P004634: view genomic region
(about GC identifiers)
Start:
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4,634,723 bp from pter |
End:
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4,636,905 bp from pter |
Size:
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2,183 bases |
Orientation:
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plus strand |
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Proteins
for MED11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MED11_HUMAN, Q9P086 (See
protein sequence)Recommended Name: Mediator of RNA polymerase II transcription subunit 11 Size: 117 amino acids; 13129 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinctmodule termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module insupporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinctsubunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAF28974.1; Type=Erroneous initiation;
Secondary accessions: Q6NS89Explore the universe of human proteins at neXtProt for MED11: NX_Q9P086
MED11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001683.1
ENSEMBL proteins: ENSP00000460400 ENSP00000459834 ENSP00000293777 Reactome Protein details: Q9P086
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
MED11 for ontologies About GeneDecksing
MED11 Antibody Products:
Assay Products for MED11: |
Protein
Domains /
Families
for MED11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MED11 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P086ProtoNet protein and cluster: Q9P086 UniProtKB/Swiss-Prot: MED11_HUMAN, Q9P086Similarity: Belongs to the Mediator complex subunit 11 family |
Function
for MED11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MED11_HUMAN, Q9P086Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatoryproteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by directinteractions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complexwith RNA polymerase II and the general transcription factors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MED11 (NM_001001683) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MED11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED11 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 12584197 |
MED11 for ontologies About GeneDecksing
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Pathways & Interactions
for MED11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Transcriptional Regulation of White Adipocyte Differentiation | | | 2 | Axon guidance | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for MED11
MED11 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MED11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/78 Interacting proteins for MED11 (Q9P0861, 3 ENSP000002937774) via UniProtKB, MINT, STRING, and/or I2D (see all 78)About this table
|
Drugs & Compounds
for MED11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MED11
Search CenterWatch for drugs/clinical trials and news about MED11
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Transcripts
for MED11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MED11 gene: NM_001001683.2 Unigene Cluster for MED11: Mediator complex subunit 11 Hs.743492 [show with all ESTs]Unigene Representative Sequence: BQ9349813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000575284 ENST00000573708 ENST00000293777(uc002fyp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MED11 (NM_001001683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MED11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED11 |
Additional cDNA sequence: AF161414.1 BC070377.1 5 DOTS entries: DT.448143 DT.92042621 DT.86855536 DT.97841222 DT.101958809 24/114 AceView cDNA sequences (see all 114): AA732688 BE843013 CR624732 AW163652 BM726370 AI424680 AI878846 CB140035 BQ478154 AA806707 AA705046 BF114944 AI476731 BM999250 BM999677 AI347645 BU782606 AA772058 BG402774 BM999143 CB853179 BX643285 AF161414 AL531790
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MED11 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for MED11
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Expression
for MED11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MED11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTGCCCC
About this image
See MED11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MED11
SOURCE GeneReport for Unigene cluster: Hs.743492
SABiosciences Custom PCR Arrays for MED11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED11 |
Orthologs
for MED11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MED11 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for MED11 (if available)
TreeFam Gene Tree for MED11 (if available) |
Paralogs
for MED11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MED11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MED11 (4634723 - 4636905 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MED11
1 CNV: 4985 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED11 |
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Disorders
/ Diseases
for MED11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MED11 for disorders About GeneDecksing
OMIM gene information: 612383
OMIM disorders: --
1  disease for MED11: About MalaCardslymphedema
Export disorders for MED11 gene to outside databases
|
Publications
for MED11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MED11 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MED11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S....Conaway R.C. (2004)
- Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2, 3 Sato S....Conaway J.W. (2003)
- MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
- Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. (PubMed id 14638676)1 Tomomori-Sato C....Conaway J.W. (2004)
- A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. (PubMed id 14576168)1 Sato S.... Conaway J.W. (2003)
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External Searches for MED11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MED11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MED11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MED11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MED11 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MED11 gene:
Search GeneIP for patents involving MED11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MED11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MED11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED11 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MED11 | | OriGene 3'-UTR Clone for MED11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MED11 | | OriGene Custom Protein Services for MED11 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MED11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED11 |
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 |  |  |  | |
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 | | | MED11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED11 |
|  |  |  | | | | Search ThermoFisher Antibodies for MED11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED11 |
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