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MED11 Gene

protein-coding   GIFtS: 46
GCID: GC17P004634

Mediator Complex Subunit 11

(Previous names: mediator of RNA polymerase II transcription, subunit 11...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 111 2 3
Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog (S.
Cerevisiae)1
Mediator Of RNA Polymerase II Transcription Subunit 112
Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog2

External Ids:    HGNC: 326871   Entrez Gene: 4005692   Ensembl: ENSG000001619207   OMIM: 6123835   UniProtKB: Q9P0863   

Export aliases for MED11 gene to outside databases

Previous GC identifers: GC17P004582 GC17P004523


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED11 Gene:
MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate
transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)

GeneCards Summary for MED11 Gene:
MED11 (mediator complex subunit 11) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot: MED11_HUMAN, Q9P086
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED11 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED11 promoter sequence
   Search Chromatin IP Primers for MED11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

MED11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004634:  view genomic region     (about GC identifiers)

Start:
4,634,723 bp from pter      End:
4,636,905 bp from pter
Size:
2,183 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MED11_HUMAN, Q9P086 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 11  
Size: 117 amino acids; 13129 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Sequence caution: Sequence=AAF28974.1; Type=Erroneous initiation;
Secondary accessions: Q6NS89

Explore the universe of human proteins at neXtProt for MED11: NX_Q9P086

Explore proteomics data for MED11 at MOPED


See MED11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001001683.1  
ENSEMBL proteins: 
 ENSP00000460400   ENSP00000459834   ENSP00000293777  
Reactome Protein details: Q9P086

MED11 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for MED11

 
Search eBioscience for Proteins for MED11 

 
antibodies-online proteins for MED11 (6 products) 

 
Search antibodies-online for peptides for MED11

MED11 Antibody Products:

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MED11 Assay Products:

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Cloud-Clone Corp. CLIAs for MED11
Search eBioscience for ELISAs for MED11 
antibodies-online kits for MED11 (18 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR019404 Mediator_Med11

Graphical View of Domain Structure for InterPro Entry Q9P086

ProtoNet protein and cluster: Q9P086

UniProtKB/Swiss-Prot: MED11_HUMAN, Q9P086
Similarity: Belongs to the Mediator complex subunit 11 family


Find genes that share domains with MED11           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MED11_HUMAN, Q9P086
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001104RNA polymerase II transcription cofactor activity IEA--
GO:0005515protein binding IPI12584197
     
Find genes that share ontologies with MED11           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Med11 (no phenotypes)

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Animal Models:
     MGI mouse knock-out Med11tm1(KOMP)Vlcg for MED11

   genOway: Develop your customized and physiologically relevant rodent model for MED11

miRNA
Products:
    
miRTarBase miRNAs that target MED11:
hsa-mir-3157-5p (MIRT052666)

Block miRNA regulation of human, mouse, rat MED11 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate MED11
SwitchGear 3'UTR luciferase reporter plasmidMED11 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MED11
Predesigned siRNA for gene silencing in human, mouse, rat MED11

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MED11

Clone
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OriGene clones in human, mouse for MED11 (see all 6)
OriGene ORF clones in mouse, rat for MED11
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GenScript: all cDNA clones in your preferred vector: MED11 (NM_001001683)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED11

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for MED11 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED11


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MED11_HUMAN, Q9P086: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016592mediator complex IDA14638676

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MED11 About    
See pathways by source

SuperPathContained pathways About
1Fatty acid, triacylglycerol, and ketone body metabolism
Fatty acid, triacylglycerol, and ketone body metabolism0.65
PPARA Activates Gene Expression0.63
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
Transcriptional Regulation of White Adipocyte Differentiation0.38
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
3L1CAM interactions
Developmental Biology0.63


Find genes that share SuperPaths with MED11           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 Reactome Pathways for MED11
    Transcriptional regulation of white adipocyte differentiation
PPARA activates gene expression


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED11
Interactions:

    Search GeneGlobe Interaction Network for MED11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MED11 (Q9P0861, 3 ENSP000002937774) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
InteractantInteraction Details
GeneCardExternal ID(s)
MED22Q155281, 3, ENSP000003423434EBI-394704,EBI-394687 I2D: score=4 STRING: ENSP00000342343
MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
MED25Q71SY53, ENSP000003267674I2D: score=1 STRING: ENSP00000326767
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006357regulation of transcription from RNA polymerase II promoter ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MED11



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MED11 gene: 
NM_001001683.2  

Unigene Cluster for MED11:

Mediator complex subunit 11
Hs.513885  [show with all ESTs]
Unigene Representative Sequence: BQ934981
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000575284 ENST00000573708 ENST00000293777(uc002fyp.3)
miRNA
Products:
     
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SwitchGear 3'UTR luciferase reporter plasmidMED11 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MED11
Predesigned siRNA for gene silencing in human, mouse, rat MED11
Clone
Products:
     
OriGene clones in human, mouse for MED11 (see all 6)
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MED11 (NM_001001683)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED11
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MED11
OriGene qSTAR qPCR primer pairs in human, mouse for MED11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED11
  QuantiTect SYBR Green Assays in human, mouse, rat MED11
  QuantiFast Probe-based Assays in human, mouse, rat MED11

Additional mRNA sequence: 

AF161414.1 BC070377.1 

7 DOTS entries:

DT.448143  DT.86855536  DT.92042621  DT.100691935  DT.97841222  DT.101958809  DT.92429708 

Selected AceView cDNA sequences (see all 114):

BQ478154 BE843013 CB140035 CR624732 AI878846 AI424680 AW163652 AA732688 
BM726370 CF529757 AA865299 BQ019588 BU623751 AW341850 AI308994 BM999250 
BX099732 CA442108 AA927115 BF114944 BG503911 AL531790 AA355467 BQ934981 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MED11    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:                              
SP2:              -               


ECgene alternative splicing isoforms for MED11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MED11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGCTGCCCC
MED11 Expression
About this image

MED11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MED11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.513885
    Custom PCR Arrays for MED11
Primer
Products:
OriGene qPCR primer pairs and template standards for MED11
OriGene qSTAR qPCR primer pairs in human, mouse for MED11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED11
QuantiTect SYBR Green Assays in human, mouse, rat MED11
QuantiFast Probe-based Assays in human, mouse, rat MED11
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MED11 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Med111 , 5 mediator of RNA polymerase II transcription, subunit more5
mediator complex subunit 111
89.17(n)1
97.44(a)1
  11 (42.99 cM)5
661721  NM_025397.21  NP_079673.21 
 704519195 
tropical clawed frog
(Xenopus tropicalis)
Amphibia med111 mediator complex subunit 11 69.25(n)
78.45(a)
  395010  NM_204048.1  NP_989379.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1005349831 mediator of RNA polymerase II transcription subunit more 64.56(n)
68.47(a)
  100534983  XM_003199346.2  XP_003199394.1 
fruit fly
(Drosophila melanogaster)
Insecta MED111 Mediator complex subunit 11 55.88(n)
45.1(a)
  40042  NM_140800.3  NP_649057.1 


ENSEMBL Gene Tree for MED11 (if available)
TreeFam Gene Tree for MED11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MED11 (see all 111)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs790277301,2
C--4619317(+) TCTAC-/AAAAAA 1 -- us2k10--------
rs44338561,2
C,F,H--4619403(+) ttgagC/Tatggg 1 -- us2k124Minor allele frequency- T:0.06NS EA NA WA CSA 1878
rs1838070391,2
--4619463(+) GCAGCA/GGAGTG 1 -- us2k10--------
rs43876481,2
C,F,H--4619468(+) AGAGTG/AAGACC 1 -- us2k111Minor allele frequency- A:0.24NS EA NA WA 782
rs1133767461,2
C--4619474(+) AGACCC/TTGTCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs80649791,2
C,A--4619498(+) TTTTTT/AAAAAA 1 -- us2k1 tfbs34Minor allele frequency- A:0.14NA WA EA 242
rs80765031,2
C--4619584(+) ttgagA/Gcaggg 1 -- us2k110Minor allele frequency- G:0.06NA WA CSA EA 370
rs1878720311,2
--4619594(+) GTCGCA/GTTCTG 1 -- us2k10--------
rs1159211021,2
C,F--4619697(+) AAGCTG/CGGAAT 1 -- us2k11Minor allele frequency- C:0.04WA 118
rs1501857481,2
--4619806(+) CACTCC/TTGTAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MED11 (4634723 - 4636905 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MED11:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1952CNV Insertion18451855
nsv833346CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MED11
DNA2.0 Custom Variant and Variant Library Synthesis for MED11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612383    OMIM disorders: --


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Genetic Association Database (GAD): MED11

Export disorders for MED11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MED11 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with MED11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S.... Conaway R.C. (Mol. Cell 2004)
  2. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1, 2, 3 Sato S....Conaway J.W. (J. Biol. Chem. 2003)
  3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
  4. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
  5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
  7. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (amp 2013)
  8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
  9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  10. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 400569 HGNC: 32687 AceView: MGC88387 Ensembl:ENSG00000161920 euGenes: HUgn400569
ECgene: MED11 H-InvDB: MED11

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MED11 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MED11 gene:
Search GeneIP for patents involving MED11

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MED11  
 OriGene qPCR primer pairs and template standards for MED11   Browse OriGene Protein Over-expression Lysates  
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 Block miRNA regulation of human, mouse, rat MED11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MED11
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 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED11  Search GeneGlobe Interaction Network for MED11
 Regulatory tfbs in MED11 promoter
 GenScript Custom Purified and Recombinant Proteins Services for MED11 GenScript cDNA clones with any tag delivered in your preferred vector for MED11
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 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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 Novus Biologicals
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 Browse ESI BIO Cell Lines and PureStem Progenitors for MED11
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 SwitchGear 3'UTR luciferase reporter plasmids for MED11
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED11
 Browse compounds at ApexBio
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 genOway: Develop your customized and physiologically relevant rodent model for MED11
  Search antibodies-online for antibodies for MED11
 antibodies-online kits for MED11 (18 products)
  Search antibodies-online for peptides for MED11
 antibodies-online proteins for MED11 (6 products)
       
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