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Aliases for MED11 Gene

Aliases for MED11 Gene

  • Mediator Complex Subunit 11 2 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 11 3
  • HSPC296 3

External Ids for MED11 Gene

Previous GeneCards Identifiers for MED11 Gene

  • GC17P004582
  • GC17P004634
  • GC17P004523

Summaries for MED11 Gene

Entrez Gene Summary for MED11 Gene

  • MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED11 Gene

MED11 (Mediator Complex Subunit 11) is a Protein Coding gene. Diseases associated with MED11 include med23. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED11 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED11 Gene

Genomics for MED11 Gene

Regulatory Elements for MED11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED11 Gene

Start:
4,731,428 bp from pter
End:
4,733,610 bp from pter
Size:
2,183 bases
Orientation:
Plus strand

Genomic View for MED11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED11 Gene

Proteins for MED11 Gene

  • Protein details for MED11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P086-MED11_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 11
    Protein Accession:
    Q9P086
    Secondary Accessions:
    • Q6NS89

    Protein attributes for MED11 Gene

    Size:
    117 amino acids
    Molecular mass:
    13129 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAF28974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MED11 Gene

Proteomics data for MED11 Gene at MOPED

Post-translational modifications for MED11 Gene

No Post-translational modifications

Other Protein References for MED11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED11 Gene

Domains for MED11 Gene

Protein Domains for MED11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P086

UniProtKB/Swiss-Prot:

MED11_HUMAN :
  • Q9P086
Family:
  • Belongs to the Mediator complex subunit 11 family.
genes like me logo Genes that share domains with MED11: view

No data available for Gene Families for MED11 Gene

Function for MED11 Gene

Molecular function for MED11 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO) - Molecular Function for MED11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 12584197
genes like me logo Genes that share ontologies with MED11: view

Animal Model Products

CRISPR Products

miRNA for MED11 Gene

miRTarBase miRNAs that target MED11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED11 Gene

Localization for MED11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED11 Gene COMPARTMENTS Subcellular localization image for MED11 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MED11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IDA 14638676
genes like me logo Genes that share ontologies with MED11: view

Pathways for MED11 Gene

genes like me logo Genes that share pathways with MED11: view

Gene Ontology (GO) - Biological Process for MED11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MED11: view

Transcripts for MED11 Gene

mRNA/cDNA for MED11 Gene

Unigene Clusters for MED11 Gene

Mediator complex subunit 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for MED11 Gene

GeneLoc Exon Structure for
MED11
ECgene alternative splicing isoforms for
MED11

Expression for MED11 Gene

mRNA expression in normal human tissues for MED11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED11 Gene

SOURCE GeneReport for Unigene cluster for MED11 Gene Hs.513885

genes like me logo Genes that share expressions with MED11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED11 Gene

Orthologs for MED11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED11 35
  • 100 (n)
  • 100 (a)
MED11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED11 35
  • 91.74 (n)
  • 98.29 (a)
MED11 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED11 35
  • 91.45 (n)
  • 100 (a)
MED11 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med11 35
  • 89.17 (n)
  • 97.44 (a)
Med11 16
Med11 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED11 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med11 35
  • 87.82 (n)
  • 96.15 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia med11 35
  • 69.25 (n)
  • 78.45 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534983 35
  • 64.56 (n)
  • 68.47 (a)
med11 36
  • 52 (a)
OneToMany
med11 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MED11 35
  • 55.88 (n)
  • 45.1 (a)
MED11 36
  • 27 (a)
OneToOne
Species with no ortholog for MED11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED11 Gene

ENSEMBL:
Gene Tree for MED11 (if available)
TreeFam:
Gene Tree for MED11 (if available)

Paralogs for MED11 Gene

No data available for Paralogs for MED11 Gene

Variants for MED11 Gene

Sequence variations from dbSNP and Humsavar for MED11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2271166 -- 4,731,664(+) TTGGG(A/G)AGGGA intron-variant
rs4387648 -- 4,729,736(+) AGAGT(A/G)AGACC upstream-variant-2KB
rs4433856 -- 4,729,671(+) ttgag(C/T)atggg upstream-variant-2KB
rs4471743 -- 4,730,358(+) atagg(A/G)gatgg upstream-variant-2KB
rs4790696 -- 4,733,721(+) CTTCG(C/T)TGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED11 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv1952 CNV Insertion 18451855

Relevant External Links for MED11 Gene

HapMap Linkage Disequilibrium report
MED11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED11 Gene

Disorders for MED11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MED11 Gene including...

Search for MED11 Gene in MalaCards »

Relevant External Links for MED11

Genetic Association Database (GAD)
MED11
genes like me logo Genes that share disorders with MED11: view

No data available for UniProtKB/Swiss-Prot for MED11 Gene

Publications for MED11 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4
  2. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 2 3 4
  3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  5. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. (PMID: 20133760) Malovannaya A. … Qin J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for MED11 Gene

Sources for MED11 Gene

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