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Aliases for MED11 Gene

Aliases for MED11 Gene

  • Mediator Complex Subunit 11 2 3 4 5
  • Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 11 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 11 3
  • HSPC296 3

External Ids for MED11 Gene

Previous GeneCards Identifiers for MED11 Gene

  • GC17P004582
  • GC17P004634
  • GC17P004523

Summaries for MED11 Gene

Entrez Gene Summary for MED11 Gene

  • MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED11 Gene

MED11 (Mediator Complex Subunit 11) is a Protein Coding gene. Diseases associated with MED11 include Cataract 8, Multiple Types. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED11 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED11 Gene

Genomics for MED11 Gene

Regulatory Elements for MED11 Gene

Enhancers for MED11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G004724 0.9 Ensembl ENCODE 5.1 -5.6 -5607 2.0 CTCF ESRRA MTA2 MLLT1 PRDM10 REST ZNF18 EGR2 CXCL16 MINK1 GGT6 LOC101928000 ZFP3 MED11 GC17M004721 GC17P004725
GH17G004730 1.1 ENCODE 0.7 -0.1 -102 2.0 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 CXCL16 LOC101928000 GC17M004714 MED11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MED11 on UCSC Golden Path with GeneCards custom track

Promoters for MED11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090528 92 1401 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for MED11 Gene

Chromosome:
17
Start:
4,731,408 bp from pter
End:
4,733,610 bp from pter
Size:
2,203 bases
Orientation:
Plus strand

Genomic View for MED11 Gene

Genes around MED11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED11 Gene

Proteins for MED11 Gene

  • Protein details for MED11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P086-MED11_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 11
    Protein Accession:
    Q9P086
    Secondary Accessions:
    • Q6NS89

    Protein attributes for MED11 Gene

    Size:
    117 amino acids
    Molecular mass:
    13129 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    SequenceCaution:
    • Sequence=AAF28974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MED11 Gene

Post-translational modifications for MED11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED11 Gene

No data available for DME Specific Peptides for MED11 Gene

Domains & Families for MED11 Gene

Gene Families for MED11 Gene

Protein Domains for MED11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P086

UniProtKB/Swiss-Prot:

MED11_HUMAN :
  • Belongs to the Mediator complex subunit 11 family.
Family:
  • Belongs to the Mediator complex subunit 11 family.
genes like me logo Genes that share domains with MED11: view

Function for MED11 Gene

Molecular function for MED11 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 12584197
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MED11: view
genes like me logo Genes that share phenotypes with MED11: view

Animal Models for MED11 Gene

MGI Knock Outs for MED11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED11 Gene

Localization for MED11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED11 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MED11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IDA 14638676
genes like me logo Genes that share ontologies with MED11: view

Pathways & Interactions for MED11 Gene

genes like me logo Genes that share pathways with MED11: view

Gene Ontology (GO) - Biological Process for MED11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED11: view

No data available for SIGNOR curated interactions for MED11 Gene

Drugs & Compounds for MED11 Gene

No Compound Related Data Available

Transcripts for MED11 Gene

mRNA/cDNA for MED11 Gene

Unigene Clusters for MED11 Gene

Mediator complex subunit 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for MED11 Gene

GeneLoc Exon Structure for
MED11
ECgene alternative splicing isoforms for
MED11

Expression for MED11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED11 Gene

Protein differential expression in normal tissues from HIPED for MED11 Gene

This gene is overexpressed in Breast (30.3) and Heart (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED11 Gene



NURSA nuclear receptor signaling pathways regulating expression of MED11 Gene:

MED11

SOURCE GeneReport for Unigene cluster for MED11 Gene:

Hs.513885

Evidence on tissue expression from TISSUES for MED11 Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with MED11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED11 Gene

Orthologs for MED11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED11 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia MED11 34 35
  • 91.74 (n)
dog
(Canis familiaris)
Mammalia MED11 34 35
  • 91.45 (n)
mouse
(Mus musculus)
Mammalia Med11 34 16 35
  • 89.17 (n)
rat
(Rattus norvegicus)
Mammalia Med11 34
  • 87.82 (n)
oppossum
(Monodelphis domestica)
Mammalia MED11 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med11 34
  • 69.25 (n)
zebrafish
(Danio rerio)
Actinopterygii med11 34 35 35
  • 64.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta MED11 34 35
  • 55.88 (n)
Species where no ortholog for MED11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED11 Gene

ENSEMBL:
Gene Tree for MED11 (if available)
TreeFam:
Gene Tree for MED11 (if available)

Paralogs for MED11 Gene

No data available for Paralogs for MED11 Gene

Variants for MED11 Gene

Sequence variations from dbSNP and Humsavar for MED11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000820610 -- 4,732,275(+) AAAAA(G/T)TAGCT intron-variant
rs1000851633 -- 4,732,015(+) CCCAG(C/T)CGGCC intron-variant
rs1001370188 -- 4,730,321(+) GGTGT(A/G)AGCCA upstream-variant-2KB
rs1001427583 -- 4,730,929(+) ATCCC(A/G)GCACT upstream-variant-2KB
rs1001903939 -- 4,733,481(+) ATGCT(C/G)CTGCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MED11 Gene

Variant ID Type Subtype PubMed ID
nsv1952 CNV insertion 18451855
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897

Variation tolerance for MED11 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED11 Gene

Disorders for MED11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MED11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 8, multiple types
  • cataract 8 multiple types
- elite association - COSMIC cancer census association via MalaCards
Search MED11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MED11

Genetic Association Database (GAD)
MED11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED11
genes like me logo Genes that share disorders with MED11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED11 Gene

Publications for MED11 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4 64
  2. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S. … Conaway J.W. (J. Biol. Chem. 2003) 2 3 4 64
  3. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3 64

Products for MED11 Gene

Sources for MED11 Gene

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