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Aliases for MED10 Gene

Aliases for MED10 Gene

  • Mediator Complex Subunit 10 2 3 4 5
  • Transformation-Related Gene 17 Protein 3 4
  • Transformation-Related Gene 20 Protein 3 4
  • TRG-17 3 4
  • TRG-20 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 10 Homolog (NUT2, S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 10 3
  • NUT2 Homolog (S. Cerevisiae) 2
  • TRG20 3
  • NUT2 3
  • L6 3

External Ids for MED10 Gene

Previous GeneCards Identifiers for MED10 Gene

  • GC05M006428

Summaries for MED10 Gene

Entrez Gene Summary for MED10 Gene

  • MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED10 Gene

MED10 (Mediator Complex Subunit 10) is a Protein Coding gene. Diseases associated with MED10 include Neonatal Abstinence Syndrome and Keratosis, Seborrheic, Somatic. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED10 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED10 Gene

Genomics for MED10 Gene

Regulatory Elements for MED10 Gene

Enhancers for MED10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MED10 on UCSC Golden Path with GeneCards custom track

Promoters for MED10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED10 Gene

Chromosome:
5
Start:
6,371,881 bp from pter
End:
6,378,594 bp from pter
Size:
6,714 bases
Orientation:
Minus strand

Genomic View for MED10 Gene

Genes around MED10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED10 Gene

Proteins for MED10 Gene

  • Protein details for MED10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTT4-MED10_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 10
    Protein Accession:
    Q9BTT4
    Secondary Accessions:
    • C6G491

    Protein attributes for MED10 Gene

    Size:
    135 amino acids
    Molecular mass:
    15688 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED10 Gene

Proteomics data for MED10 Gene at MOPED

Post-translational modifications for MED10 Gene

  • Ubiquitination at Lys 53, Lys 82, Lys 106, and Lys 115
  • Modification sites at PhosphoSitePlus

Other Protein References for MED10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED10 Gene

Domains & Families for MED10 Gene

Gene Families for MED10 Gene

Protein Domains for MED10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTT4

UniProtKB/Swiss-Prot:

MED10_HUMAN :
  • Belongs to the Mediator complex subunit 10 family.
Family:
  • Belongs to the Mediator complex subunit 10 family.
genes like me logo Genes that share domains with MED10: view

Function for MED10 Gene

Molecular function for MED10 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA,IBA --
genes like me logo Genes that share ontologies with MED10: view
genes like me logo Genes that share phenotypes with MED10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED10 Gene

Localization for MED10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED10 Gene COMPARTMENTS Subcellular localization image for MED10 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with MED10: view

Pathways & Interactions for MED10 Gene

genes like me logo Genes that share pathways with MED10: view

Gene Ontology (GO) - Biological Process for MED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0019827 stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with MED10: view

No data available for SIGNOR curated interactions for MED10 Gene

Drugs & Compounds for MED10 Gene

No Compound Related Data Available

Transcripts for MED10 Gene

mRNA/cDNA for MED10 Gene

Unigene Clusters for MED10 Gene

Mediator complex subunit 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED10 Gene

No ASD Table

Relevant External Links for MED10 Gene

GeneLoc Exon Structure for
MED10
ECgene alternative splicing isoforms for
MED10

Expression for MED10 Gene

mRNA expression in normal human tissues for MED10 Gene

Protein differential expression in normal tissues from HIPED for MED10 Gene

This gene is overexpressed in Bone (33.6) and Breast (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED10 Gene



SOURCE GeneReport for Unigene cluster for MED10 Gene Hs.13885

genes like me logo Genes that share expression patterns with MED10: view

Protein tissue co-expression partners for MED10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED10 Gene

Orthologs for MED10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MED10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED10 35
  • 92.59 (n)
  • 100 (a)
MED10 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED10 35
  • 93.27 (n)
  • 98.08 (a)
MED10 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med10 35
  • 89.63 (n)
  • 99.26 (a)
Med10 16
Med10 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED10 35
  • 99.75 (n)
  • 100 (a)
MED10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med10 35
  • 90.12 (n)
  • 99.26 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MED10 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED10 35
  • 82.84 (n)
  • 94.78 (a)
MED10 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED10 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med10 35
  • 80.25 (n)
  • 95.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20889 35
zebrafish
(Danio rerio)
Actinopterygii med10 35
  • 78.11 (n)
  • 88.81 (a)
med10 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED10_ANOGA 35
  • 63.85 (n)
  • 61.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED10 35
  • 63.8 (n)
  • 60.94 (a)
MED10 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-10 35
  • 51.91 (n)
  • 44.26 (a)
mdt-10 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUT2 38
Species with no ortholog for MED10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED10 Gene

ENSEMBL:
Gene Tree for MED10 (if available)
TreeFam:
Gene Tree for MED10 (if available)

Paralogs for MED10 Gene

Pseudogenes.org Pseudogenes for MED10 Gene

genes like me logo Genes that share paralogs with MED10: view

No data available for Paralogs for MED10 Gene

Variants for MED10 Gene

Sequence variations from dbSNP and Humsavar for MED10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs4592 -- 6,372,135(+) AGAAA(A/G)AGTAT utr-variant-3-prime
rs9451 -- 6,372,472(+) GTCCC(A/G)GGGGA utr-variant-3-prime
rs9666 -- 6,372,148(-) TTTTT(C/T)TTTTA utr-variant-3-prime
rs15010 -- 6,372,029(+) AATAT(A/T)ATACC utr-variant-3-prime
rs905140 -- 6,375,224(+) CACCT(A/G)CCTTT intron-variant

Variation tolerance for MED10 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MED10 Gene

Disorders for MED10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MED10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
neonatal abstinence syndrome
  • drug withdrawal syndrome in newborn
keratosis, seborrheic, somatic
  • seborrheic keratosis
- elite association - COSMIC cancer census association via MalaCards
Search MED10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MED10

Genetic Association Database (GAD)
MED10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED10
genes like me logo Genes that share disorders with MED10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED10 Gene

Publications for MED10 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4 67
  2. Determination of the 'critical region' for cat-like cry of Cri-du-chat syndrome and analysis of candidate genes by quantitative PCR. (PMID: 15657623) Wu Q. … Hansen L. (Eur. J. Hum. Genet. 2005) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MED10 Gene

Sources for MED10 Gene

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