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Aliases for MED10 Gene

Aliases for MED10 Gene

  • Mediator Complex Subunit 10 2 3 4
  • Transformation-Related Gene 17 Protein 3 4
  • Transformation-Related Gene 20 Protein 3 4
  • TRG-17 3 4
  • TRG-20 3 4
  • NUT2 3 6
  • Mediator Of RNA Polymerase II Transcription, Subunit 10 Homolog (NUT2, S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 10 3
  • Mediator Of RNA Polymerase II Transcription Subunit 10 3
  • NUT2 Homolog (S. Cerevisiae) 2
  • TRG20 3
  • L6 3

External Ids for MED10 Gene

Previous GeneCards Identifiers for MED10 Gene

  • GC05M006428

Summaries for MED10 Gene

Entrez Gene Summary for MED10 Gene

  • MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED10 Gene

MED10 (Mediator Complex Subunit 10) is a Protein Coding gene. Diseases associated with MED10 include cri-du-chat syndrome and med23. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED10 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED10 Gene

Genomics for MED10 Gene

Regulatory Elements for MED10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MED10 Gene

Start:
6,371,881 bp from pter
End:
6,378,594 bp from pter
Size:
6,714 bases
Orientation:
Minus strand

Genomic View for MED10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED10 Gene

Proteins for MED10 Gene

  • Protein details for MED10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTT4-MED10_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 10
    Protein Accession:
    Q9BTT4
    Secondary Accessions:
    • C6G491

    Protein attributes for MED10 Gene

    Size:
    135 amino acids
    Molecular mass:
    15688 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED10 Gene

Proteomics data for MED10 Gene at MOPED

Post-translational modifications for MED10 Gene

  • Ubiquitination at Lys53, Lys82, Lys106, and Lys115
  • Modification sites at PhosphoSitePlus

Other Protein References for MED10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MED10 Gene

Domains for MED10 Gene

Protein Domains for MED10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTT4

UniProtKB/Swiss-Prot:

MED10_HUMAN :
  • Q9BTT4
Family:
  • Belongs to the Mediator complex subunit 10 family.
genes like me logo Genes that share domains with MED10: view

No data available for Gene Families for MED10 Gene

Function for MED10 Gene

Molecular function for MED10 Gene

UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Gene Ontology (GO) - Molecular Function for MED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 14576168
genes like me logo Genes that share ontologies with MED10: view

Phenotypes for MED10 Gene

GenomeRNAi human phenotypes for MED10:
genes like me logo Genes that share phenotypes with MED10: view

Animal Model Products

CRISPR Products

miRNA for MED10 Gene

miRTarBase miRNAs that target MED10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MED10 Gene

Localization for MED10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED10 Gene COMPARTMENTS Subcellular localization image for MED10 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with MED10: view

Pathways for MED10 Gene

genes like me logo Genes that share pathways with MED10: view

Gene Ontology (GO) - Biological Process for MED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0019827 stem cell maintenance IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MED10: view

Transcripts for MED10 Gene

mRNA/cDNA for MED10 Gene

Unigene Clusters for MED10 Gene

Mediator complex subunit 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED10 Gene

No ASD Table

Relevant External Links for MED10 Gene

GeneLoc Exon Structure for
MED10
ECgene alternative splicing isoforms for
MED10

Expression for MED10 Gene

mRNA expression in normal human tissues for MED10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED10 Gene

SOURCE GeneReport for Unigene cluster for MED10 Gene Hs.13885

genes like me logo Genes that share expressions with MED10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED10 Gene

Orthologs for MED10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MED10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED10 35
  • 99.75 (n)
  • 100 (a)
MED10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED10 35
  • 92.59 (n)
  • 100 (a)
MED10 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED10 35
  • 93.27 (n)
  • 98.08 (a)
MED10 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med10 35
  • 89.63 (n)
  • 99.26 (a)
Med10 16
Med10 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MED10 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med10 35
  • 90.12 (n)
  • 99.26 (a)
chicken
(Gallus gallus)
Aves MED10 35
  • 82.84 (n)
  • 94.78 (a)
MED10 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED10 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20889 35
tropical clawed frog
(Silurana tropicalis)
Amphibia med10 35
  • 80.25 (n)
  • 95.56 (a)
zebrafish
(Danio rerio)
Actinopterygii med10 35
  • 78.11 (n)
  • 88.81 (a)
med10 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED10_ANOGA 35
  • 63.85 (n)
  • 61.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED10 35
  • 63.8 (n)
  • 60.94 (a)
MED10 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-10 35
  • 51.91 (n)
  • 44.26 (a)
mdt-10 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUT2 38
Species with no ortholog for MED10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED10 Gene

ENSEMBL:
Gene Tree for MED10 (if available)
TreeFam:
Gene Tree for MED10 (if available)

Paralogs for MED10 Gene

Pseudogenes.org Pseudogenes for MED10 Gene

genes like me logo Genes that share paralogs with MED10: view

No data available for Paralogs for MED10 Gene

Variants for MED10 Gene

Sequence variations from dbSNP and Humsavar for MED10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4592 -- 6,372,135(+) AGAAA(A/G)AGTAT utr-variant-3-prime
rs9451 -- 6,372,472(+) GTCCC(A/G)GGGGA utr-variant-3-prime
rs9666 -- 6,372,148(-) TTTTT(C/T)TTTTA utr-variant-3-prime
rs15010 -- 6,372,029(+) AATAT(A/T)ATACC utr-variant-3-prime
rs905140 -- 6,375,224(+) CACCT(A/G)CCTTT intron-variant

Relevant External Links for MED10 Gene

HapMap Linkage Disequilibrium report
MED10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MED10 Gene

Disorders for MED10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MED10 Gene including...

Search for MED10 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MED10 Gene

Relevant External Links for MED10

Genetic Association Database (GAD)
MED10
genes like me logo Genes that share disorders with MED10: view

No data available for UniProtKB/Swiss-Prot for MED10 Gene

Publications for MED10 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S. … Conaway R.C. (Mol. Cell 2004) 2 3 4
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4
  3. Determination of the 'critical region' for cat-like cry of Cri-du-chat syndrome and analysis of candidate genes by quantitative PCR. (PMID: 15657623) Wu Q. … Hansen L. (Eur. J. Hum. Genet. 2005) 2 3
  4. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X. … Roeder R.G. (Mol. Cell 2005) 3 4
  5. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PMID: 10993082) Akoulitchev S. … Reinberg D. (Nature 2000) 3 4

Products for MED10 Gene

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