Aliases for MED10 Gene
External Ids for MED10 Gene
Previous GeneCards Identifiers for MED10 Gene
MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
GeneCards Summary for MED10 Gene
MED10 (Mediator Complex Subunit 10) is a Protein Coding gene. Diseases associated with MED10 include Neonatal Abstinence Syndrome and Keratosis, Seborrheic, Somatic. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.
UniProtKB/Swiss-Prot for MED10 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.