Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MED10 Gene

protein-coding   GIFtS: 53
GCID: GC05M006371

Mediator Complex Subunit 10

(Previous names: mediator of RNA polymerase II transcription, subunit 10...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mediator Complex Subunit 101 2 3     Mediator Of RNA Polymerase II Transcription, Subunit 10 Homolog (NUT2, S.
Cerevisiae)1
Transformation-Related Gene 17 Protein2 3     NUT2 Homolog (S. Cerevisiae)1
Transformation-Related Gene 20 Protein2 3     TRG202
TRG-172 3     Mediator Of RNA Polymerase II Transcription Subunit 102
TRG-202 3     Mediator Of RNA Polymerase II Transcription, Subunit 102
NUT22 5     

External Ids:    HGNC: 287601   Entrez Gene: 842462   Ensembl: ENSG000001333987   OMIM: 6123825   UniProtKB: Q9BTT43   

Export aliases for MED10 gene to outside databases

Previous GC identifer: GC05M006428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MED10 Gene:
MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate
transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).(supplied by OMIM, Oct 2008)

GeneCards Summary for MED10 Gene:
MED10 (mediator complex subunit 10) is a protein-coding gene. Diseases associated with MED10 include seborrheic keratosis, and cri-du-chat syndrome. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot: MED10_HUMAN, Q9BTT4
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED10 gene promoter:
         NRSF form 1   NRSF form 2   Tal-1beta   E47   HEN1   AREB6   Nkx6-1   Zic3   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED10 promoter sequence
   Search Chromatin IP Primers for MED10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.31   Ensembl cytogenetic band:  5p15.31   HGNC cytogenetic band: 5p15.31

MED10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M006371:  view genomic region     (about GC identifiers)

Start:
6,371,994 bp from pter      End:
6,378,707 bp from pter
Size:
6,714 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MED10_HUMAN, Q9BTT4 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 10  
Size: 135 amino acids; 15688 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP
Secondary accessions: C6G491

Explore the universe of human proteins at neXtProt for MED10: NX_Q9BTT4

Explore proteomics data for MED10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys53, Lys82, Lys106, Lys115
  • Modification sites at PhosphoSitePlus

  • See MED10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115662.2  
    ENSEMBL proteins: 
     ENSP00000255764  
    Reactome Protein details: Q9BTT4

    MED10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MED10
    OriGene Protein Over-expression Lysate for MED10
    OriGene MassSpec for MED10
    OriGene Custom Protein Services for MED10
    GenScript Custom Purified and Recombinant Proteins Services for MED10
    Novus Biologicals MED10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED10

    MED10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED10
    Novus Biologicals MED10 Antibodies
    Abcam antibodies for MED10
    Cloud-Clone Corp. Antibodies for MED10
    Search ThermoFisher Antibodies for MED10
    LSBio Antibodies in human, mouse, rat for MED10

    MED10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED10
    Cloud-Clone Corp. CLIAs for MED10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR019145 Mediator_Med10

    Graphical View of Domain Structure for InterPro Entry Q9BTT4

    ProtoNet protein and cluster: Q9BTT4

    UniProtKB/Swiss-Prot: MED10_HUMAN, Q9BTT4
    Similarity: Belongs to the Mediator complex subunit 10 family


    MED10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED10_HUMAN, Q9BTT4
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IEA--
         
    MED10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MED10:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED10

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED10:
    hsa-mir-124-3p (MIRT023131)

    Block miRNA regulation of human, mouse, rat MED10 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MED10:
    hsa-miR-188-3p hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidMED10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED10
    Predesigned siRNA for gene silencing in human, mouse, rat MED10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED10

    Clone
    Products:
         
    OriGene clones in human, mouse for MED10 (see all 6)
    OriGene ORF clones in mouse, rat for MED10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED10 (NM_006827)
    Sino Biological Human cDNA Clone for MED10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED10
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MED10_HUMAN, Q9BTT4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0016592mediator complex IEA--

    MED10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MED10 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4L1CAM interactions
    Developmental Biology0.63
    5Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MED10
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    3 Reactome Pathways for MED10
        Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression



    MED10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MED10
    Interactions:

        Search GeneGlobe Interaction Network for MED10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED10 (Q9BTT42, 3 ENSP000002557644) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDM4BO949532, 3, ENSP000001591114MINT-65334 I2D: score=4 STRING: ENSP00000159111
    NAP1L1P552092, 3, ENSP000002611824MINT-8263544 I2D: score=2 STRING: ENSP00000261182
    MOB4Q9Y3A32, 3MINT-65839 I2D: score=5 
    PEBP1P300862, 3MINT-65335 I2D: score=4 
    ENSG00000234258P349313, ENSP000003964864I2D: score=1 STRING: ENSP00000396486
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019827stem cell maintenance IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    MED10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MED10 gene: 
    NM_032286.2  

    Unigene Cluster for MED10:

    Mediator complex subunit 10
    Hs.13885  [show with all ESTs]
    Unigene Representative Sequence: BG335164
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255764(uc003jdo.3) ENST00000503112 ENST00000504058
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED10 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MED10:
    hsa-miR-188-3p hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidMED10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED10
    Predesigned siRNA for gene silencing in human, mouse, rat MED10
    Clone
    Products:
         
    OriGene clones in human, mouse for MED10 (see all 6)
    OriGene ORF clones in mouse, rat for MED10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED10 (NM_006827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MED10
    OriGene qSTAR qPCR primer pairs in human, mouse for MED10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MED10
      QuantiTect SYBR Green Assays in human, mouse, rat MED10
      QuantiFast Probe-based Assays in human, mouse, rat MED10

    Additional mRNA sequence: 

    AY277599.1 AY453397.1 AY598325.1 BC003353.1 

    7 DOTS entries:

    DT.101963980  DT.440550  DT.91682431  DT.100779959  DT.97808447  DT.100779960  DT.101966189 

    Selected AceView cDNA sequences (see all 209):

    BX092103 AW295708 CA952401 BU738047 CA444101 NM_032286 AA460004 BM312476 
    BE313495 AI985005 AW780008 AA648258 CB158002 BF445457 AW082075 BE278138 
    BM696608 BQ002965 BU684730 BQ448318 AY598325 AK075493 BU752461 AI581734 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MED10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTATAATAA
    MED10 Expression
    About this image

    MED10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13885
        Custom PCR Arrays for MED10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MED10
    OriGene qSTAR qPCR primer pairs in human, mouse for MED10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MED10
    QuantiTect SYBR Green Assays in human, mouse, rat MED10
    QuantiFast Probe-based Assays in human, mouse, rat MED10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MED10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med101 , 5 mediator of RNA polymerase II transcription, subunit more5
    mediator complex subunit 101
    89.63(n)1
    99.26(a)1
      13 (35.55 cM)5
    280771  NM_138596.21  NP_613062.11 
     698098825 
    chicken
    (Gallus gallus)
    Aves MED101 mediator complex subunit 10 82.84(n)
    94.78(a)
      420940  XM_004935133.1  XP_004935190.1 
    lizard
    (Anolis carolinensis)
    Reptilia MED106
    mediator complex subunit 10
    93(a)
    1 ↔ 1
    GL343211.1(2517096-2527708)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208892 Xenopus laevis transcribed sequence with weak similarity more 81.94(n)    BQ897449.1 
    zebrafish
    (Danio rerio)
    Actinopterygii med101 mediator of RNA polymerase II transcription, subunit more 78.11(n)
    88.81(a)
      550394  NM_001017699.1  NP_001017699.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MED101 Mediator complex subunit 10 63.8(n)
    60.94(a)
      39777  NM_001275002.1  NP_001261931.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mdt-101 mdt-10 51.91(n)
    44.26(a)
      188311  NM_063249.4  NP_495650.1 


    ENSEMBL Gene Tree for MED10 (if available)
    TreeFam Gene Tree for MED10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MED10 gene

    MED10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MED10
    PGOHUM00000233597


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MED10 (see all 202)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437589531,2
    --6371584(+) AACTGC/GGGCCC 1 -- int10--------
    rs727160791,2
    --6371585(+) ACTGGC/GGCCCT 1 -- int10--------
    rs743740441,2
    C,F--6371590(+) GGCCCT/CACCTT 1 -- int13Minor allele frequency- C:0.10CSA WA 122
    rs177751951,2
    C,F,H--6371680(+) CCAAGG/CGTGGC 1 -- int111Minor allele frequency- C:0.08NA NS EA 1058
    rs730401851,2
    C--6371752(+) CGGACG/ATGTGA 1 -- int12Minor allele frequency- A:0.05WA 120
    rs558868591,2
    C,F--6371826(+) CCTGCC/TGGGCG 1 -- int18Minor allele frequency- T:0.18NA NS WA EA 736
    rs22505231,2
    C,F,A,H--6371954(+) TTCTTC/ATGAAT 1 -- int125Minor allele frequency- A:0.50EA NA NS WA CSA 3281
    rs726510791,2
    C,F--6372085(+) ATCCAT/AGAAAA 1 -- ut312Minor allele frequency- A:0.01NS 324
    rs1859591061,2
    --6372220(+) GCTTTC/TGGACA 1 -- ut310--------
    rs1481494571,2
    --6372221(+) CTTTCA/GGACAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MED10 (6371994 - 6378707 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MED10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MED10
    DNA2.0 Custom Variant and Variant Library Synthesis for MED10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612382    OMIM disorders: --

    10 diseases for MED10:    
    About MalaCards
    seborrheic keratosis    cri-du-chat syndrome    junctional epidermolysis bullosa    keratosis
    epidermolysis bullosa    meningitis    lung cancer    malaria
    hypoxia    melanoma

    2 diseases from the University of Copenhagen DISEASES database for MED10:
    Junctional epidermolysis bullosa     Seborrheic keratosis

    MED10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MED10

    Export disorders for MED10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MED10 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with MED10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2, 3 Sato S.... Conaway R.C. (Mol. Cell 2004)
    2. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PubMed id 15989967)1, 2 Zhang X....Roeder R.G. (Mol. Cell 2005)
    3. Determination of the 'critical region' for cat-like cry of Cri-du-chat syndrome and analysis of candidate genes by quantitative PCR. (PubMed id 15657623)1, 3 Wu Q....Hansen L. (Eur. J. Hum. Genet. 2005)
    4. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    5. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)1, 2 Akoulitchev S.... Reinberg D. (Nature 2000)
    6. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (Mol. Cell 1999)
    7. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. (PubMed id 23322298)1 Davis M.A....Clurman B.E. (amp 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84246 HGNC: 28760 AceView: MGC5309 Ensembl:ENSG00000133398 euGenes: HUgn84246
    ECgene: MED10 H-InvDB: MED10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MED10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MED10 gene:
    Search GeneIP for patents involving MED10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MED10  
     OriGene qPCR primer pairs and template standards for MED10   OriGene Protein Over-expression Lysate for MED10  
     OriGene MassSpec something-or-other for MED10   OriGene clones in human, mouse for MED10  
     OriGene qSTAR qPCR primer pairs in human, mouse for MED10   OriGene Purified Protein for MED10  
     OriGene ORF clones in mouse, rat for MED10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MED10   OriGene Custom Protein Services for MED10  

     
     
     Block miRNA regulation of human, mouse, rat MED10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MED10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED10 Predesigned siRNA for gene silencing in human, mouse, rat MED10
     QuantiFast Probe-based Assays in human, mouse, rat MED10 QuantiTect SYBR Green Assays in human, mouse, rat MED10
     Custom PCR Arrays for MED10 Search Chromatin IP Primers for MED10
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MED10  Search GeneGlobe Interaction Network for MED10
     Regulatory tfbs in MED10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MED10 GenScript cDNA clones with any tag delivered in your preferred vector for MED10
     GenScript Custom Assay Services for MED10 GenScript Custom overexpressing Cell Line Services for MED10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MED10
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MED10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MED10 antibodies
     MED10 lysates
     Antibodies for MED10
     See all of Abcam's Antibodies, Kits and Proteins for MED10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MED10
     Antibodies for MED10
     ELISAs for MED10
     CLIAs for MED10



     Browse ESI BIO Cell Lines and PureStem Progenitors for MED10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED10
     SwitchGear 3'UTR luciferase reporter plasmids for MED10
     SwitchGear Promoter luciferase reporter plasmids for MED10
     Search ThermoFisher Antibodies for MED10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED10
     LSBio Antibodies in human, mouse, rat for MED10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MED10 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4