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Aliases for MED1 Gene

Aliases for MED1 Gene

  • Mediator Complex Subunit 1 2 3 4
  • Thyroid Hormone Receptor-Associated Protein Complex 220 KDa Component 3 4
  • Vitamin D Receptor-Interacting Protein Complex Component DRIP205 3 4
  • Peroxisome Proliferator-Activated Receptor-Binding Protein 3 4
  • Activator-Recruited Cofactor 205 KDa Component 3 4
  • Thyroid Receptor-Interacting Protein 2 3 4
  • P53 Regulatory Protein RB18A 3 4
  • TR-Interacting Protein 2 3 4
  • PPAR Binding Protein 2 3
  • PPAR-Binding Protein 3 4
  • PPARGBP 3 4
  • CRSP200 3 4
  • DRIP205 3 4
  • DRIP230 3 4
  • TRAP220 3 4
  • PPARBP 3 4
  • ARC205 3 4
  • TRIP-2 3 4
  • TRIP2 3 4
  • CRSP1 3 4
  • RB18A 3 4
  • PBP 3 4
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP220 3
  • Vitamin D Receptor-Interacting Protein 230 KD 3
  • Thyroid Receptor Interacting Protein 2 3
  • PPARG Binding Protein 3

External Ids for MED1 Gene

Previous HGNC Symbols for MED1 Gene

  • TRIP2
  • PPARGBP
  • PPARBP

Previous GeneCards Identifiers for MED1 Gene

  • GC17M034815
  • GC17M037560
  • GC17M033354

Summaries for MED1 Gene

Entrez Gene Summary for MED1 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED1 Gene

MED1 (Mediator Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and GPCR Pathway. GO annotations related to this gene include chromatin binding and receptor activity.

UniProtKB/Swiss-Prot for MED1 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Gene Wiki entry for MED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED1 Gene

Genomics for MED1 Gene

Regulatory Elements for MED1 Gene

Genomic Location for MED1 Gene

Chromosome:
17
Start:
39,404,285 bp from pter
End:
39,451,286 bp from pter
Size:
47,002 bases
Orientation:
Minus strand

Genomic View for MED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED1 Gene

Proteins for MED1 Gene

  • Protein details for MED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15648-MED1_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 1
    Protein Accession:
    Q15648
    Secondary Accessions:
    • A2RRQ6
    • O43810
    • O75447
    • Q6P9H7
    • Q6PK58
    • Q9HD39

    Protein attributes for MED1 Gene

    Size:
    1581 amino acids
    Molecular mass:
    168478 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3 (By similarity). Interacts with GATA1 and CCAR1. Interacts with NR4A3 (By similarity).
    SequenceCaution:
    • Sequence=AAC39854.1; Type=Frameshift; Positions=543, 545; Evidence={ECO:0000305}; Sequence=AAH06517.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAA73867.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MED1 Gene

    Alternative splice isoforms for MED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED1 Gene

Proteomics data for MED1 Gene at MOPED

Post-translational modifications for MED1 Gene

  • Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED1 Gene

Antibody Products

No data available for DME Specific Peptides for MED1 Gene

Domains & Families for MED1 Gene

Gene Families for MED1 Gene

Protein Domains for MED1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15648

UniProtKB/Swiss-Prot:

MED1_HUMAN :
  • Belongs to the Mediator complex subunit 1 family.
Family:
  • Belongs to the Mediator complex subunit 1 family.
genes like me logo Genes that share domains with MED1: view

Function for MED1 Gene

Molecular function for MED1 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Gene Ontology (GO) - Molecular Function for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS --
GO:0001047 core promoter binding IDA 17641689
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with MED1: view
genes like me logo Genes that share phenotypes with MED1: view

Animal Models for MED1 Gene

MGI Knock Outs for MED1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MED1 Gene

Localization for MED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED1 Gene

Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED1 Gene COMPARTMENTS Subcellular localization image for MED1 gene
Compartment Confidence
nucleus 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16314496
genes like me logo Genes that share ontologies with MED1: view

Pathways & Interactions for MED1 Gene

genes like me logo Genes that share pathways with MED1: view

PCR Array Products

SIGNOR curated interactions for MED1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0000902 cell morphogenesis IMP 17223341
GO:0001525 angiogenesis ISS --
GO:0001701 in utero embryonic development --
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with MED1: view

Drugs & Compounds for MED1 Gene

(6) Drugs for MED1 Gene - From: DrugBank and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ampicillin Approved Pharma 50
Estradiol Approved, Investigational Pharma Sex hormone 1057
5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL Experimental Pharma Target 0
estrogen Pharma 0
vitamin d Pharma 1463

(6) Additional Compounds for MED1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-Lactam
glutamate
Penicillin
retinoic acid
302-79-4
Retinoid
genes like me logo Genes that share compounds with MED1: view

Transcripts for MED1 Gene

Unigene Clusters for MED1 Gene

Mediator complex subunit 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MED1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2: - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for MED1 Gene

GeneLoc Exon Structure for
MED1
ECgene alternative splicing isoforms for
MED1

Expression for MED1 Gene

mRNA expression in normal human tissues for MED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED1 Gene

This gene is overexpressed in Lung (16.8), Blymphocyte (8.6), Monocytes (6.8), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED1 Gene



SOURCE GeneReport for Unigene cluster for MED1 Gene Hs.643754

mRNA Expression by UniProt/SwissProt for MED1 Gene

Q15648-MED1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MED1: view

Protein tissue co-expression partners for MED1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MED1 Gene

Orthologs for MED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED1 35
  • 95.22 (n)
  • 97.46 (a)
MED1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED1 35
  • 94.88 (n)
  • 97.6 (a)
MED1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med1 35
  • 90.17 (n)
  • 94.09 (a)
Med1 16
Med1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED1 35
  • 99.83 (n)
  • 99.94 (a)
MED1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med1 35
  • 90.73 (n)
  • 94.7 (a)
oppossum
(Monodelphis domestica)
Mammalia MED1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED1 35
  • 78.94 (n)
  • 87.58 (a)
MED1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med1 35
  • 67.85 (n)
  • 73.72 (a)
Str.18690 35
zebrafish
(Danio rerio)
Actinopterygii med1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MED1 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for MED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED1 Gene

ENSEMBL:
Gene Tree for MED1 (if available)
TreeFam:
Gene Tree for MED1 (if available)

Paralogs for MED1 Gene

No data available for Paralogs for MED1 Gene

Variants for MED1 Gene

Sequence variations from dbSNP and Humsavar for MED1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1139819 -- 39,451,222(-) ACCCT(C/T)CTCTT utr-variant-5-prime
rs1139820 -- 39,415,113(-) GCAGG(A/G)CTCAA reference, missense
rs1139821 -- 39,415,110(-) GGACT(C/T)AACAC reference, missense
rs1139822 -- 39,410,534(-) CTACA(C/T)CAACC reference, missense, intron-variant
rs1139823 -- 39,410,504(-) CCATT(A/G)CCACC reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED1 Gene

Variant ID Type Subtype PubMed ID
nsv908204 CNV Gain 21882294

Variation tolerance for MED1 Gene

Residual Variation Intolerance Score: .96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED1 Gene

HapMap Linkage Disequilibrium report
MED1

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED1 Gene

Disorders for MED1 Gene

Relevant External Links for MED1

Genetic Association Database (GAD)
MED1
Human Genome Epidemiology (HuGE) Navigator
MED1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED1
genes like me logo Genes that share disorders with MED1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED1 Gene

Publications for MED1 Gene

  1. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. (PMID: 10485914) Zhu Y. … Reddy J.K. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 23 67
  2. Peroxisome-proliferator-activated receptor-binding protein (PBP) is essential for the growth of active Notch4-immortalized mammary epithelial cells by activating SOX10 expression. (PMID: 19852756) Zhu Y.T. … Zhu Y.J. (Biochem. J. 2010) 23 67
  3. MiR-205 silences MED1 in hypoxic primary human trophoblasts. (PMID: 20065103) Mouillet J.F. … Sadovsky Y. (FASEB J. 2010) 23 67
  4. Molecular determinants of the interactions between LXR/RXR heterodimers and TRAP220. (PMID: 19410560) Son Y.L. … Lee Y.C. (Biochem. Biophys. Res. Commun. 2009) 23 67
  5. Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling. (PMID: 19416972) Makkonen K.M. … Carlberg C. (J. Biol. Chem. 2009) 23 67

Products for MED1 Gene

Sources for MED1 Gene

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