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MED1 Gene

protein-coding   GIFtS: 58
GCID: GC17M037560

Mediator Complex Subunit 1

(Previous name: PPAR binding protein)
(Previous symbols: TRIP2, PPARGBP, PPARBP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mediator Complex Subunit 11 2 3     CRSP2002 3
PPARBP1 2 3 5     DRIP2052 3
PPARGBP1 2 3     DRIP2302 3
TRIP21 2 3     RB18A2 3
PBP2 3 5     TRIP-22 3
TRAP2202 3 5     P53 Regulatory Protein RB18A2 3
PPAR Binding Protein1 2     PPAR-Binding Protein2 3
Activator-Recruited Cofactor 205 KDa Component2 3     TR-Interacting Protein 22 3
Peroxisome Proliferator-Activated Receptor-Binding Protein2 3     Mediator Of RNA Polymerase II Transcription Subunit 12
Thyroid Hormone Receptor-Associated Protein Complex 220 KDa Component2 3     PPARG Binding Protein2
Thyroid Receptor-Interacting Protein 22 3     Thyroid Hormone Receptor-Associated Protein Complex Component TRAP2202
Vitamin D Receptor-Interacting Protein Complex Component DRIP2052 3     Thyroid Receptor Interacting Protein 22
ARC2052 3     Vitamin D Receptor-Interacting Protein 230 KD2
CRSP12 3     Trap2203

External Ids:    HGNC: 92341   Entrez Gene: 54692   Ensembl: ENSG000001256867   OMIM: 6043115   UniProtKB: Q156483   

Export aliases for MED1 gene to outside databases

Previous GC identifers: GC17M034815 GC17M033354


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MED1 Gene:
The activation of gene transcription is a multistep process that is triggered by factors that recognize
transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation
by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required
for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein
is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which
interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and
cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known
to have the ability to self-oligomerize. (provided by RefSeq, Jul 2008)

GeneCards Summary for MED1 Gene:
MED1 (mediator complex subunit 1) is a protein-coding gene. Diseases associated with MED1 include thyroiditis, and otitis media. GO annotations related to this gene include transcription coactivator activity and chromatin binding.

UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MED1 gene promoter:
         GR   Elk-1   MAZR   Meis-1b   GATA-1   STAT3   c-Myb   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMED1 promoter sequence
   Search Chromatin IP Primers for MED1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MED1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

MED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037560:  view genomic region     (about GC identifiers)

Start:
37,560,538 bp from pter      End:
37,607,539 bp from pter
Size:
47,002 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 1  
Size: 1581 amino acids; 168478 Da
Subunit: Interacts with GATA1 and YWHAH (By similarity). Component of the Mediator complex, which is composed of
MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19,
MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The
MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8
module is less active than Mediator lacking this module in supporting transcriptional activation. Individual
preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP,
DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a
ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RXRA, RXRG, THRA, THRB and VDR. Interacts with
CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Binds DNA
Sequence caution: Sequence=AAC39854.1; Type=Frameshift; Positions=543, 545; Sequence=AAH06517.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAA73867.1;
Type=Frameshift; Positions=4;
Selected PDB 3D structures from and Proteopedia for MED1 (see all 23):
1RJK (3D)        1RK3 (3D)        1RKG (3D)        1RKH (3D)        2O4J (3D)        2O4R (3D)    
Secondary accessions: A2RRQ6 O43810 O75447 Q6P9H7 Q6PK58 Q9HD39
Alternative splicing: 2 isoforms:  Q15648-1   Q15648-3   

Explore the universe of human proteins at neXtProt for MED1: NX_Q15648

Explore proteomics data for MED1 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the
    nucleolus1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MED1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004765.2  
    ENSEMBL proteins: 
     ENSP00000377828   ENSP00000300651   ENSP00000463307   ENSP00000462441  
    Reactome Protein details: Q15648

    MED1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MED1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MED1
    GenScript Custom Purified and Recombinant Proteins Services for MED1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MED1

    MED1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MED1 (TRAP220)
    OriGene Antibodies for MED1
    OriGene Custom Antibody Services for MED1
    Search for Antibodies for MED1 at Abcam
    Cloud-Clone Corp. Antibodies for MED1
    Search ThermoFisher Antibodies for MED1
    LSBio Antibodies in human, mouse, rat for MED1

    MED1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MED1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MED1
    Cloud-Clone Corp. CLIAs for MED1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019680 Mediator_Med1_met/fun

    Graphical View of Domain Structure for InterPro Entry Q15648

    ProtoNet protein and cluster: Q15648

    UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648
    Similarity: Belongs to the Mediator complex subunit 1 family


    MED1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED1_HUMAN, Q15648
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0001047core promoter binding IDA17641689
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003677DNA binding ----
         
    MED1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MED1:
     Increased G1 DNA content  Increased cell size 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Med1) (see all 17):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  pigmentation 

    MED1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MED1: Med1tm1.1Mpk Med1tm1Jkr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MED1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MED1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MED1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MED1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MED1:
    hsa-mir-125b-5p (MIRT046058), hsa-mir-10a-5p (MIRT047640), hsa-mir-96-5p (MIRT027932), hsa-mir-30c-5p (MIRT047844), hsa-mir-205-5p (MIRT003239)

    Block miRNA regulation of human, mouse, rat MED1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED1 (see all 129):
    hsa-miR-579 hsa-miR-1321 hsa-miR-146a hsa-miR-605 hsa-miR-128 hsa-miR-3916 hsa-miR-877* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidMED1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MED1
    Predesigned siRNA for gene silencing in human, mouse, rat MED1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MED1

    Clone
    Products:
         
    OriGene clones in human, mouse for MED1 (see all 9)
    OriGene ORF clones in mouse, rat for MED1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED1 (NM_004774)
    Sino Biological Human cDNA Clone for MED1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MED1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MED1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MED1_HUMAN, Q15648: Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation
    by MAPK1 or MAPK3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0016592mediator complex IMP17641689

    MED1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MED1 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Circadian Repression of Expression by REV-ERBA
    Circadian Repression of Expression by REV-ERBA0.88
    YAP1- and WWTR1 (TAZ)-stimulated gene expression0.40
    RORA Activates Circadian Expression0.88
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75
    4Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MED1
        Estrogen Pathway

    2 GeneGo (Thomson Reuters) Pathways for MED1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription PPAR Pathway

    3 BioSystems Pathways for MED1
        Energy Metabolism
    RXR and RAR heterodimerization with other nuclear receptor
    Coregulation of Androgen receptor activity


    Selected Reactome Pathways for MED1 (see all 12)
        Transcriptional regulation of white adipocyte differentiation
    Circadian Clock
    Nuclear Receptor transcription pathway
    Generic Transcription Pathway
    Transcriptional activation of mitochondrial biogenesis


    1 Kegg Pathway  (Kegg details for MED1):
        Thyroid hormone signaling pathway


    MED1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MED1: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MED1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MED1 (Q156481, 2, 3 ENSP000003006514) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102761, 2, 3, ENSP000002540664EBI-394459,EBI-413374 MINT-5209905 I2D: score=4 STRING: ENSP00000254066
    KAT2AQ928302, 3, ENSP000002259164MINT-6744331 MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-7985641 I2D: score=1 STRING: ENSP00000225916
    CDK8P493362, 3, ENSP000003709384MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000370938
    MED15Q96RN52, 3, ENSP000002632054MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000263205
    TP53P046372, 3, ENSP000002693054MINT-58467 MINT-58470 MINT-58464 I2D: score=4 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 65):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000902cell morphogenesis IMP17223341
    GO:0001525angiogenesis ISS--
    GO:0001701in utero embryonic development ----
    GO:0001889liver development IEA--

    MED1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MED1

    1 DrugBank Compound for MED1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MED1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 63.2 5 9653119 (2), 12403843 (1), 16269453 (1)
    steroid 48.6 15 10760302 (2), 10770935 (1), 19183483 (1), 18048071 (1) (see all 11)
    penicillin 46.1 9 1856478 (1), 8314292 (1), 10853344 (1), 9462268 (1) (see all 7)
    beta-lactam 45.4 1 8314292 (1)
    estrogen 41.4 18 15471764 (3), 10770935 (2), 10485914 (2), 10760302 (1) (see all 8)
    retinoic acid 36.6 7 10760302 (1), 15159591 (1), 12356758 (1), 19416972 (1) (see all 5)
    retinoid 18.5 1 16723356 (1)
    estradiol 15.5 3 10770935 (1), 14664715 (1)
    ampicillin 11.2 4 12805259 (2), 15880950 (1)
    alanine 0 2 16925449 (1), 16949543 (1)



    MED1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MED1 gene: 
    NM_004774.3  

    Unigene Cluster for MED1:

    Mediator complex subunit 1
    Hs.643754  [show with all ESTs]
    Unigene Representative Sequence: NM_004774
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394287(uc002hru.2) ENST00000300651(uc002hrv.4 uc010wee.2)
    ENST00000577831 ENST00000584308 ENST00000581334

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MED1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MED1 (see all 129):
    hsa-miR-579 hsa-miR-1321 hsa-miR-146a hsa-miR-605 hsa-miR-128 hsa-miR-3916 hsa-miR-877* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidMED1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MED1
    Predesigned siRNA for gene silencing in human, mouse, rat MED1
    Clone
    Products:
         
    OriGene clones in human, mouse for MED1 (see all 9)
    OriGene ORF clones in mouse, rat for MED1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MED1 (NM_004774)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MED1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED1
      QuantiTect SYBR Green Assays in human, mouse, rat MED1
      QuantiFast Probe-based Assays in human, mouse, rat MED1

    Additional mRNA sequence: 

    AF055994.1 AF283812.1 AK299789.1 AK314185.1 BC006517.2 BC060758.1 BC131783.1 L40366.1 
    Y13467.1 

    16 DOTS entries:

    DT.444224  DT.95370879  DT.120987305  DT.414225  DT.120987250  DT.95255394  DT.100024552  DT.92428884 
    DT.100754451  DT.101971725  DT.40223263  DT.91772552  DT.92035250  DT.95362953  DT.91676981  DT.92032263 

    Selected AceView cDNA sequences (see all 278):

    CA441224 BF434852 H43324 BM707082 AI419037 AW029165 AI290952 BP357374 
    AW263061 AW959712 R83230 AA923575 AI097436 BM825135 BM837206 BM459441 
    BE670750 AA772170 AA151593 BX496308 BC060758 BX119034 BU619502 AF283812 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MED1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                  
    SP2:                    -           -                                                                                 
    SP3:                    -           -           -                                                                     
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for MED1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MED1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MED1 Expression
    About this image

    MED1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MED1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643754

    UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MED1: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              PPAR Targets in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MED1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MED1
    QuantiTect SYBR Green Assays in human, mouse, rat MED1
    QuantiFast Probe-based Assays in human, mouse, rat MED1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MED1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Med11 , 5 mediator complex subunit 11, 5 90.17(n)1
    94.09(a)1
      11 (61.75 cM)5
    190141  NM_001080118.11  NP_001073587.11 
     981521545 
    chicken
    (Gallus gallus)
    Aves MED11 mediator complex subunit 1 78.94(n)
    87.58(a)
      420004  XM_418125.4  XP_418125.3 
    lizard
    (Anolis carolinensis)
    Reptilia MED16
    mediator complex subunit 1
    85(a)
    1 ↔ 1
    6(67729379-67751060)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.186902 Transcribed sequence with moderate similarity to protein more 72.25(n)    BX764850.1 
    zebrafish
    (Danio rerio)
    Actinopterygii med16
    mediator complex subunit 1
    54(a)
    1 ↔ 1
    12(16137528-16158727) ENSDARG00000075340
    fruit fly
    (Drosophila melanogaster)
    Insecta MED16
    Mediator complex subunit 1
    22(a)
    1 ↔ 1
    3L(21621425-21627546)


    ENSEMBL Gene Tree for MED1 (if available)
    TreeFam Gene Tree for MED1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MED1 (see all 1022)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428539941,2
    --33403004(+) GCCTCC/TTGGGT 1 -- us2k10--------
    rs1871712551,2
    --33403061(+) GGTGTA/GTGCCA 1 -- us2k10--------
    rs1484767351,2
    --37560537(+) GGCAAA/TTTACT 1 -- ds50010--------
    rs1924451071,2
    --37560622(+) AGATTA/TCATCT 1 -- ut310--------
    rs1848720271,2
    --37560623(+) GATTTA/CATCTA 1 -- ut310--------
    rs1887584881,2
    C--37560662(+) ATTTAA/CAAAAC 1 -- ut310--------
    rs1897556321,2
    --37560773(+) GTTCTC/TATAGC 1 -- ut310--------
    rs1816365401,2
    --37560848(+) AAGGAC/TAGAAA 1 -- ut310--------
    rs1867724391,2
    --37560864(+) GGGGGG/TCAGGG 1 -- ut310--------
    rs1426361741,2
    --37560887(+) AGGAAA/CAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MED1 (37560538 - 37607539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MED1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908204CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing MED1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing MED1
    DNA2.0 Custom Variant and Variant Library Synthesis for MED1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604311    OMIM disorders: --

    Selected diseases for MED1 (see all 29):    
    About MalaCards
    thyroiditis    otitis media    conjunctivitis    rickets
    gestational diabetes    sporadic breast cancer    ataxia telangiectasia    alopecia
    pneumonia    thyroid cancer    nasopharyngitis    lung adenocarcinoma
    breast cancer    ataxia    influenza    mental retardation
    parkinson's disease    diabetes mellitus    ovarian cancer    retinitis


    MED1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for MED1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute otitis media 54.3 3 10853344 (2), 11876602 (1)
    breast cancer 20 11 10485914 (5), 19183483 (1), 15471764 (1)
    tumors 0 6 10485914 (2), 17229543 (1)

    Genetic Association Database (GAD): MED1
    Human Genome Epidemiology (HuGE) Navigator: MED1 (28 documents)

    Export disorders for MED1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MED1 gene, integrated from 10 sources (see all 224):
    (articles sorted by number of sources associating them with MED1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. (PubMed id 10485914)1, 3, 9 Zhu Y....Reddy J.K. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. (PubMed id 15471764)1, 2, 9 Wu Q.... Safe S. (J. Biol. Chem. 2004)
    3. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. (PubMed id 9653119)1, 2, 9 Yuan C.-X.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. (PubMed id 10770935)1, 2, 9 Burakov D.... Freedman L.P. (J. Biol. Chem. 2000)
    5. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PubMed id 12218053)1, 2, 9 Wang Q.... Fondell J.D. (J. Biol. Chem. 2002)
    6. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. (PubMed id 14636573)1, 2, 9 Wallberg A.E.... Roeder R.G. (Mol. Cell 2003)
    7. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. (PubMed id 10733574)1, 2, 9 Rachez C....Freedman L.P. (Mol. Cell. Biol. 2000)
    8. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4, 9 Haiman C.A....Press M.F. (BMC Cancer 2009)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    10. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PubMed id 19255064)1, 4 Ahn J....Hayes R.B. (Carcinogenesis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5469 HGNC: 9234 AceView: PPARBP Ensembl:ENSG00000125686 euGenes: HUgn5469
    ECgene: MED1 Kegg: 5469 H-InvDB: MED1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MED1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MED1 gene:
    Search GeneIP for patents involving MED1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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