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MED1 Gene

protein-coding GIFtS: 56

GC17M034815

mediator complex subunit 1
(Previous name: PPAR binding protein )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: TRIP2, PPARGBP, PPARBP)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARC205 ^³
CRSP1 ^¹, ², ³
CRSP200 ^¹, ², ³
DRIP205 ^², ³
DRIP230 ^¹, ², ³
MBD4 ^⁵
MGC71488 ^²
PBP ^¹, ², ³
PPARBP ^², ³
PPARGBP ^², ³
RB18A ^¹, ², ³
TRAP220 ^¹, ², ³
TRIP-2 ^³
TRIP2 ^², ³
Trap220 ^³

Descriptions
Activator-recruited cofactor 205 kDa component ^³
PPAR binding protein ^¹, ²
PPAR-binding protein ^³
PPARG binding protein ^²
Peroxisome proliferator-activated receptor-binding protein ^³
Thyroid hormone receptor-associated protein complex 220 kDa component ^³
Thyroid receptor-interacting protein 2 ^³
Vitamin D receptor-interacting protein complex component DRIP205 ^², ³
mediator complex subunit 1 ^², ³
p53 regulatory protein RB18A ^³
thyroid hormone receptor-associated protein complex component TRAP220 ^²
thyroid receptor interacting protein 2 ^²
vitamin D receptor-interacting protein 230 kD ^²

External Ids
HGNC: 9234¹
Entrez Gene: 5469²
UniProtKB: Q15648³
Ensembl: ENSG00000125686⁷

Search outside databases for aliases for MED1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MED1:

The activation of gene transcription is a multistep process that is triggered by factors that

recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct

transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is

a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is

required for efficient activation by SP1. This protein is also a component of other multisubunit

complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and

facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It

also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known

to have the ability to self-oligomerize. [provided by RefSeq]

UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648

Function: Component of the Mediator complex, a coactivator involved in the regulated transcription

of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey

information from gene-specific regulatory proteins to the basal RNA polymerase II transcription

machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and

serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II

and the general transcription factors

Gene Wiki entry for MED1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.1 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12

MED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M034815: (about GC identifiers)

Start:	34,814,064 bp from pter
End:	34,861,053 bp from pter
Size:	46,990 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648 (See protein sequence)

Recommended Name: Mediator of RNA polymerase II transcription subunit 1

Size: 1581 amino acids; 168478 Da

Subunit: Interacts with GATA1 and YWHAH (By similarity). Component of the Mediator complex, which

is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14,

MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29,

MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a

distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than

Mediator lacking this module in supporting transcriptional activation. Individual preparations of

the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP,

DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors

in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RXRA, RXRG, THRA, THRB and

VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Binds DNA

Subcellular location: Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to

phosphorylation by MAPK1 or MAPK3

Sequence caution: Sequence=AAC39854.1; Type=Frameshift; Positions=543, 545; Sequence=AAH06517.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=CAA73867.1; Type=Frameshift; Positions=4;

PDB structures from and Proteopedia :

1RJK (3D)

1RK3 (3D)

1RKG (3D)

1RKH (3D)

2O4J (3D)

2O4R (3D)

2ZFX (3D)

Secondary accessions: A2RRQ6 O43810 O75447 Q6P9H7 Q6PK58 Q9HD39

Alternative splicing: 2 isoforms: Q15648-1 Q15648-3

Post-translational modifications:

Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote

entry into the nucleolus. Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004765.2

ENSEMBL proteins:

ENSP00000377828 ENSP00000300651

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TRAP220/MED1)
	Human Recombinant Proteins from Abnova (PPARBP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000119	mediator complex	IDA	10198638
GO:0005634	nucleus	IDA	10235267

About this table

Antibodies for MED1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MED1
	R&D Systems Antibodies for MED1 (TRAP220)
	Antibodies from Abcam (TRAP220/MED1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PPARBP)
	Novus Biologicals Antibodies for MED1

Assays for MED1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15648

ProtoNet protein and cluster: Q15648

UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648

Similarity: Belongs to the Mediator complex subunit 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MED1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPARBP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004774

Applied Biosystems Silencer® siRNAs for MED1

Sigma-Aldrich siRNA for MED1

Sigma-Aldrich shRNA Panels and shRNA for MED1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MED1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004774
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004774
untagged cDNA clones in CMV expression vector (see all 2): NM_004774

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004774

UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648

Function: Component of the Mediator complex, a coactivator involved in the regulated transcription

of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey

information from gene-specific regulatory proteins to the basal RNA polymerase II transcription

machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and

serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II

and the general transcription factors

15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Med1) (see all 16 ):

	cellular	craniofacial	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	lethality-prenatal/perinatal	limbs/digits/tail
liver/biliary system	muscle	nervous system	pigmentation	respiratory system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004872	receptor activity	IDA	12218053
GO:0005515	protein binding	IPI	16554032 16799563
GO:0016455	RNA polymerase II transcription mediator activity	IDA	10198638
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	NAS	10235266

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for MED1 (Your Favorite Gene powered by Ingenuity) (see all 10 )

Estrogen Receptor Signaling
Aryl Hydrocarbon Receptor Signaling
Xenobiotic Metabolism Signaling
p53 Signaling
TR/RXR Activation

GeneDecks MED1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MED1

5/144 Interacting proteins for MED1 (ENSP00000300651³ Q15648^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 144 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPARG	P37231¹	STRING (score=.999) EBI-394459, EBI-781384
THRA	P10827¹	STRING (score=.972) EBI-394459, EBI-286285
CDK8	P49336²	STRING (score=.998) MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675
MED15	Q96RN5²	STRING (score=.944) MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675
TRRAP	Q9Y4A5²	STRING (score=.944) MINT-6744331 MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006367	transcription initiation from RNA polymerase II promoter	IDA	12218053
GO:0030521	androgen receptor signaling pathway	IDA	12218053
GO:0045444	fat cell differentiation	IDA	12037571

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MED1
3 Novoseek chemical compound relationships for MED1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	48.70	15	10760302 (2), 10770935 (1), 19183483 (1), 18048071 (1) (see all 11)
beta-lactam	47.09	1	8314292 (1)
estradiol	17.35	3	10770935 (1), 14664715 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MED1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PPARBP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004774

Sigma-Aldrich siRNA for MED1

Sigma-Aldrich shRNA Panels and shRNA for MED1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004774

REFSEQ mRNAs for MED1 gene:

NM_004774.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004774

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004774
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004774
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004774

Additional cDNA sequence:

AF055994.1 AF283812.1 AK299789.1 AK314185.1 BC006517.2 BC060758.1 BC131783.1 CR625084.1

L40366.1 Y13467.1

15 DOTS entries:

DT.444224 DT.95370879 DT.120987305 DT.414225 DT.120987250 DT.92428884 DT.101971725 DT.40223263

DT.91772552 DT.95362953 DT.92035250 DT.95255394 DT.100754451 DT.91676981 DT.92032263

24/278 AceView cDNA sequences (see all 278 ):

BU070449 BM837206 CA424343 AI423072 R83230 AI097436 BX496308 AA281949

AA923575 CA419516 AA452610 AW470707 BM459441 AI741562 AI419037 AI569310

AA693324 BF939993 BU178461 H43324 AW510861 AU108001 BQ010445 AI381902

Unigene Cluster for MED1:

Mediator complex subunit 1

Hs.643754 [show with all ESTs]

Unigene Representative Sequence: NM_004774

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MED1 (see all 7 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16
SP1:
SP2:							-				-
SP3:							-				-				-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MED1

2 Ensembl transcripts including schematic representations:

ENST00000394287 ENST00000300651

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MED1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MED1

¹ / ²

11 probe-sets matching MED1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32064_at²	U95-A	1	1.00	1.00	0.00	0.24	--	--	--	--	--
56136_at²	U95-B	1	1.00	1.00	0.93	0.90	--	--	--	--	--
44549_at²	U95-B	1	1.00	1.00	0.91	1.10	--	--	--	--	--
225452_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
203497_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
225456_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
203496_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
225452_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203497_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225456_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203496_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MED1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.643754
UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MED1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MED1¹	--	mediator complex subunit 1	95.51(n) 98.17(a)	480533 XM_537654.2 XP_537654.2
chimpanzee (Pan troglodytes)	MED1¹	--	mediator complex subunit 1	99.83(n) 99.94(a)	454629 XM_001172395.1 XP_001172395.1
cow (Bos taurus)	MED1¹	--	mediator complex subunit 1	95.39(n) 97.59(a)	520734 XM_598984.3 XP_598984.2
rat (Rattus norvegicus)	Med1¹	--	mediator complex subunit 1	90.99(n) 94.94(a)	497991 XM_573188.2 XP_573188.1
mouse (Mus musculus)	Med1^{1, 5}	11 (61.00 cM)⁵	mediator complex subunit 1^{1, 5}	90.78(n)¹ 94.91(a)¹	19014¹ NM_001080118.1¹ NP_001073587.1¹ AA547564⁵ AF000294⁵ (see all 20)

About this table Species with no ortholog for MED1

ENSEMBL Gene Tree for MED1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/232 NCBI SNPs in MED1 are shown (see all 232 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4795369^1,2	A,C,F,H	34862646(+)	`GATGAA/GAGACA`	1	--	ng3¹		12		EU EA WA NA	1054
	rs6503513^1,2	A,C,F,H	34815139(+)	`TTGGTA/GTTTGT`	1	--	ut3¹		9		NA EU EA WA	736
--	rs4795367^1,2	A,C,F	34862369(+)	`CTAGCC/GCTTGA`	1	--	ng3¹		3		NA	132
	rs1139825^1,2	C,F,H	34819743(-)	`CTTACC/ACACAA`	1	T/P	mis¹ ese³		12		MN NA EU EA WA	1150
	rs35668211^1,2	C,F	34818282(+)	`AGAGCT/CTGAAC`	1	G/S	mis¹		5		NA EU EA WA	496
--	rs17634758^1,2	F	34817093(+)	`GGTCTG/AGATAT`	1	--	ut3¹ ese³		3		NA	142
--	rs7212868^1,2	A	34861578(+)	`cgcctA/Cggcct`	1	--	ng3¹		0	--	--	--	--
--	rs7212715^1,2	A	34861430(+)	`cctccC/Tgggtt`	1	--	ng3¹		0	--	--	--	--
	rs7211837^1,2	H	34816046(+)	`TTTTAA/GGTGAA`	1	--	ut3¹		4		EU EA WA	420
--	rs12452880^1,2	A,C,F,H	34844675(+)	`gcacaC/Gtcctc`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for MED1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603574

3 Novoseek disease relationships for MED1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acute otitis media	55.73	3	10853344 (2), 11876602 (1)
breast cancer	22.53	11	10485914 (5), 19183483 (1), 15471764 (1)
tumors	0.00	6	10485914 (2), 17229543 (1)

About this table

Human Genome Epidemiology Navigator: MED1 (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/147 PubMed articles for MED1 gene (see all 147 ):

Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. (PubMed id 10485914)^{1, 2, 3} Zhu Y....Reddy J.K. (1999)
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. (PubMed id 15471764)^{1, 3, 4} Wu Q.... Safe S. (2004)
The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. (PubMed id 9653119)^{1, 3, 4} Yuan C.-X.... Roeder R.G. (1998)
A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PubMed id 12218053)^{1, 3, 4} Wang Q.... Fondell J.D. (2002)
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. (PubMed id 14636573)^{1, 3, 4} Wallberg A.E.... Roeder R.G. (2003)
The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. (PubMed id 10733574)^{1, 3, 4} Rachez C....Freedman L.P. (2000)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. (PubMed id 16574658)^{3, 4} Udayakumar T.S.... Fondell J.D. (2006)
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. (PubMed id 16314496)^{3, 4} Pandey P.K....Fondell J.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5469	HGNC: 9234	AceView: PPARBP	Ensembl:ENSG00000125686	euGenes: HUgn5469
ECgene: MED1	H-InvDB: MED1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for MED1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MED1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MED1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MED1		Antibodies for MED1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MED1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PPARBP)
	Antibodies (PPARBP)
	Chimera RNAi (PPARBP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TRAP220/MED1)
	Antibodies (TRAP220/MED1)

Search OriGene for MED1

Search Tocris compounds for MED1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MED1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MED1 Gene at Home site.
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MED1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for MED1

Summaries
for MED1

Genomic Location
for MED1

Proteins
for MED1

Protein Domains/
Families
for MED1

Gene Function
for MED1

Pathways & Interactions
for MED1

Drugs & Compounds
for MED1

Transcripts
for MED1

Expression
for MED1

Orthologs
for MED1

Paralogs
for MED1

SNPs/Variants
for MED1

Disorders & Mutations
for MED1

Medical News
for MED1

Publications
for MED1

Search for MED1

Genome Databases showing MED1

Other Databases showing MED1

Specialized Databases showing MED1

Licensable Technologies
for MED1

Services
for MED1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MED1 (Gene Symbol)
ARC205
CRSP1
CRSP200
DRIP205
DRIP230
MBD4
MGC71488
PBP
PPARBP
PPARGBP
RB18A
TRAP220
TRIP-2
TRIP2
Trap220
Activator-recruited cofactor 205 kDa component
PPAR binding protein
PPAR-binding protein
PPARG binding protein
Peroxisome proliferator-activated receptor-binding protein
Thyroid hormone receptor-associated protein complex 220 kDa component
Thyroid receptor-interacting protein 2
Vitamin D receptor-interacting protein complex component DRIP205
mediator complex subunit 1
p53 regulatory protein RB18A
thyroid hormone receptor-associated protein complex component TRAP220
thyroid receptor interacting protein 2
vitamin D receptor-interacting protein 230 kD

MED1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor MED1

Summariesfor MED1

Genomic Locationfor MED1

Proteinsfor MED1

Protein Domains/Familiesfor MED1

Gene Functionfor MED1

Pathways & Interactionsfor MED1

Drugs & Compoundsfor MED1

Transcriptsfor MED1

Expression for MED1

Orthologsfor MED1

Paralogsfor MED1

SNPs/Variantsfor MED1

Disorders & Mutationsfor MED1

Medical Newsfor MED1

Publicationsfor MED1

Search for MED1

Genome Databases showing MED1

Other Databases showing MED1

Specialized Databases showing MED1

Licensable Technologiesfor MED1

Servicesfor MED1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MED1

Summaries
for MED1

Genomic Location
for MED1

Proteins
for MED1

Protein Domains/
Families
for MED1

Gene Function
for MED1

Pathways & Interactions
for MED1

Drugs & Compounds
for MED1

Transcripts
for MED1

Expression
for MED1

Orthologs
for MED1

Paralogs
for MED1

SNPs/Variants
for MED1

Disorders & Mutations
for MED1

Medical News
for MED1

Publications
for MED1

Licensable Technologies
for MED1

Services
for MED1