Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MED1 Gene

protein-coding   GIFtS: 54
GCID: GC17M037560

mediator complex subunit 1

(Previous name: PPAR binding protein )
(Previous symbols: TRIP2, PPARGBP, PPARBP)
 Explore 32 diseases affiliated with
MED1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MED1    

Aliases
for MED1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mediator Complex Subunit 11 2 3     Thyroid Receptor-Interacting Protein 22 3
PBP1 2 3 5     Vitamin D Receptor-Interacting Protein Complex Component DRIP2052 3
PPARBP1 2 3 5     ARC2052 3
TRAP2201 2 3 5     DRIP2052 3
CRSP11 2 3     TRIP-22 3
CRSP2001 2 3     P53 Regulatory Protein RB18A2 3
DRIP2301 2 3     PPAR-Binding Protein2 3
PPARGBP1 2 3     TR-Interacting Protein 22 3
RB18A1 2 3     Mediator Of RNA Polymerase II Transcription Subunit 12
TRIP21 2 3     PPARG Binding Protein2
PPAR Binding Protein1 2     Thyroid Hormone Receptor-Associated Protein Complex Component TRAP2202
Activator-Recruited Cofactor 205 KDa Component2 3     Thyroid Receptor Interacting Protein 22
Peroxisome Proliferator-Activated Receptor-Binding Protein2 3     Vitamin D Receptor-Interacting Protein 230 KD2
Thyroid Hormone Receptor-Associated Protein Complex 220 KDa Component2 3     Trap2203

External Ids:    HGNC: 92341   Entrez Gene: 54692   Ensembl: ENSG000001256867   OMIM: 6043115   UniProtKB: Q156483   

Export aliases for MED1 gene to outside databases

Previous GC identifers: GC17M034815 GC17M033354


Summaries
for MED1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MED1:
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional
enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA
polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1
activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a
component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with
TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates
p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to
self-oligomerize. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
with RNA polymerase II and the general transcription factors

Gene Wiki entry for MED1


Genomic Views
for MED1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MED1 gene promoter:
         GR   Elk-1   MAZR   Meis-1b   GATA-1   STAT3   c-Myb   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MED1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MED1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

MED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MED1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037560:  view genomic region     (about GC identifiers)

Start:
 37,560,538 bp from pter      End:
 37,607,539 bp from pter
Size:
 47,002 bases      Orientation:
 minus strand

Proteins
for MED1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648 (See protein sequence)
Recommended Name: Mediator of RNA polymerase II transcription subunit 1  
Size: 1581 amino acids; 168478 Da
Subunit: Interacts with GATA1 and YWHAH (By similarity). Component of the Mediator complex, which is composed of MED1,
MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20,
MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13,
CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less
active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the
Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR,
ESR1, ESR2, PPARA, PPARG, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Binds
DNA
Subcellular location: Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by
MAPK1 or MAPK3
Sequence caution: Sequence=AAC39854.1; Type=Frameshift; Positions=543, 545; Sequence=AAH06517.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAA73867.1; Type=Frameshift;
Positions=4;
6/15 PDB 3D structures from and Proteopedia for MED1 (see all 15):
1RJK (3D)        1RK3 (3D)        1RKG (3D)        1RKH (3D)        2O4J (3D)        2O4R (3D)    
Secondary accessions: A2RRQ6 O43810 O75447 Q6P9H7 Q6PK58 Q9HD39
Alternative splicing: 2 isoforms:  Q15648-1   Q15648-3   

Explore the universe of human proteins at neXtProt for MED1: NX_Q15648

Post-translational modifications:

  • Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the
    • nucleolus1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15648

    • MED1 Protein expression data from MOPED and PaxDb:    About this image 
    MED1 Protein Expression
    REFSEQ proteins: NP_004765.2  
    ENSEMBL proteins: 
     ENSP00000377828   ENSP00000300651   ENSP00000463307   ENSP00000462441  
    Reactome Protein details: Q15648
    Human Recombinant Protein Products for MED1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MED1
    OriGene Custom Protein Services for MED1 
    GenScript Custom Purified and Recombinant Proteins Services for MED1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MED1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10235267
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA16314496
    GO:0016592mediator complex IMP17641689

    MED1 for ontologies           About GeneDecksing



    MED1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MED1 (TRAP220)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MED1 
    GenScript Custom Superior Antibodies Services for MED1
    Abcam antibodies for MED1 
    Uscn Antibodies for MED1
    Search ThermoFisher Antibodies for MED1

    Assay Products for MED1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MED1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MED1

    Protein Domains /
    Families
    for MED1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MED1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019680 Mediator_Med1_met/fun

    Graphical View of Domain Structure for InterPro Entry Q15648

    ProtoNet protein and cluster: Q15648

    UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648
    Similarity: Belongs to the Mediator complex subunit 1 family


    Function
    for MED1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MED1_HUMAN, Q15648
    Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA
    polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory
    proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct
    interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex
    with RNA polymerase II and the general transcription factors

         Gene Ontology (GO): 5/22 molecular function terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0001047core promoter binding IDA17641689
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IMP17641689
         
    MED1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MED1:
     Increased G1 DNA content  Increased cell size 

         15/17 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Med1) (see all 17):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  pigmentation 

    MED1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for MED1: Med1tm1.1Mpk Med1tm1Jkr
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MED1 

    miRNA
    Products:            		miRTarBase miRNAs that target MED1:
    hsa-mir-205 (MIRT003239)

    OriGene 3'-UTR Clone: MED1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED1
    8/129 QIAGEN miScript miRNA Assays for microRNAs that regulate MED1 (see all 129):
    hsa-miR-579 hsa-miR-1321 hsa-miR-146a hsa-miR-605 hsa-miR-128 hsa-miR-3916 hsa-miR-877* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: MED1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED1 (see all 7)
    OriGene shRNA RFP: MED1
    OriGene siRNA: MED1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED1
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MED1
    Sirion Biotech Customized adenovirus for overexpression of MED1 
    Sirion Biotech Customized adenovirus for potent knockdown of MED1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED1 (NM_004774)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MED1
    Search LifeMap BioReagents cell lines for MED1
    Sirion Biotech Customized stable knockdown cell line services for MED1 
    Sirion Biotech Customized inducible knockdown cell line services for MED1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED1


    Pathways & Interactions
    for MED1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    2Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Development_Ligand-independent activation of ESR1 and ESR2
    		Transcription PPAR Pathway0.35
    		Transcription_PPAR Pathway0.35
    5HIV Infection
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MED1
        Transcription PPAR Pathway
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    2 GeneGo (Thomson Reuters) Pathways for MED1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription PPAR Pathway

    3 BioSystems Pathways for MED1 
        Energy Metabolism
    Coregulation of Androgen receptor activity
    RXR and RAR heterodimerization with other nuclear receptor

    5/9        Reactome Pathways for MED1 (see all 9)
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Metabolism



    MED1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MED1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for MED1 (Q156481, 2, 3 ENSP000003006514) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102761, 2, 3, ENSP000002540664EBI-394459,EBI-413374 MINT-5209905 I2D: score=4 STRING: ENSP00000254066
    KAT2AQ928302, 3, ENSP000002259164MINT-6744331 MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-7985641 I2D: score=1 STRING: ENSP00000225916
    CDK8P493362, 3, ENSP000003709384MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000370938
    MED15Q96RN52, 3, ENSP000002632054MINT-6744616 MINT-6744730 MINT-6744749 MINT-6744763 MINT-6754675 I2D: score=1 STRING: ENSP00000263205
    TP53P046372, 3, ENSP000002693054MINT-58467 MINT-58470 MINT-58464 I2D: score=4 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 5/64 biological process terms (GO ID links to tree view) (see all 64):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000902cell morphogenesis IMP17223341
    GO:0001525angiogenesis ISS--
    GO:0001701in utero embryonic development ----
    GO:0001889liver development IEA--

    MED1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MED1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MED1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MED1

    1 DrugBank Compound for MED1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL-- --target--10592235

    10/11 Novoseek chemical compound relationships for MED1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin d 63.2 5 9653119 (2), 12403843 (1), 16269453 (1)
    steroid 48.6 15 10760302 (2), 10770935 (1), 19183483 (1), 18048071 (1) (see all 11)
    penicillin 46.1 9 1856478 (1), 8314292 (1), 10853344 (1), 9462268 (1) (see all 7)
    beta-lactam 45.4 1 8314292 (1)
    estrogen 41.4 18 15471764 (3), 10770935 (2), 10485914 (2), 10760302 (1) (see all 8)
    retinoic acid 36.6 7 10760302 (1), 15159591 (1), 12356758 (1), 19416972 (1) (see all 5)
    retinoid 18.5 1 16723356 (1)
    estradiol 15.5 3 10770935 (1), 14664715 (1)
    ampicillin 11.2 4 12805259 (2), 15880950 (1)
    alanine 0 2 16925449 (1), 16949543 (1)

    Search CenterWatch for drugs/clinical trials and news about MED1 

    Transcripts
    for MED1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MED1 gene: 
    NM_004774.3  

    Unigene Cluster for MED1:

    Mediator complex subunit 1
    Hs.643754  [show with all ESTs]
    Unigene Representative Sequence: NM_004774
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394287(uc002hru.2) ENST00000300651(uc002hrv.4 uc010wee.2)
    ENST00000577831 ENST00000584308 ENST00000581334

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MED1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MED1
    8/129 QIAGEN miScript miRNA Assays for microRNAs that regulate MED1 (see all 129):
    hsa-miR-579 hsa-miR-1321 hsa-miR-146a hsa-miR-605 hsa-miR-128 hsa-miR-3916 hsa-miR-877* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: MED1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED1 (see all 7)
    OriGene shRNA RFP: MED1
    OriGene siRNA: MED1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED1
    Sirion Biotech Custom design and validation of potent shRNA sequences against MED1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MED1 (NM_004774)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MED1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED1

    Additional cDNA sequence: 

    AF055994.1 AF283812.1 AK299789.1 AK314185.1 BC006517.2 BC060758.1 BC131783.1 L40366.1 
    Y13467.1 

    16 DOTS entries:

    DT.444224  DT.95370879  DT.120987305  DT.414225  DT.120987250  DT.95255394  DT.92428884  DT.100024552 
    DT.101971725  DT.40223263  DT.91772552  DT.92035250  DT.95362953  DT.100754451  DT.91676981  DT.92032263 

    24/278 AceView cDNA sequences (see all 278):

    AI468768 BM459441 AA281949 AI017966 AA772170 BP363551 BU619502 BP370851 
    AW468661 AI569310 BU178461 N79458 BQ029565 BX119034 AA151593 AA452791 
    AI352382 BE670750 AW136537 AA653330 H43324 CR625084 AW510861 AI096426 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MED1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                  
    SP2:                    -           -                                                                                 
    SP3:                    -           -           -                                                                     
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for MED1

    Expression
    for MED1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MED1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    MED1 Expression
    About this image
    See MED1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MED1

    SOURCE GeneReport for Unigene cluster: Hs.643754

    UniProtKB/Swiss-Prot: MED1_HUMAN, Q15648
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including MED1: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MED1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED1

    Orthologs
    for MED1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MED1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Med11 , 5 mediator complex subunit 11, 5 90.78(n)1
    94.91(a)1    		   11 (61.75 cM)5
    190141  NM_001080118.11  NP_001073587.11 
     981521545 
    chicken
    (Gallus gallus)    		 Aves MED11 mediator complex subunit 1 79.93(n)
    88.78(a)    		   420004  XM_418125.3  XP_418125.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MED16
    		 --
    		 85(a)
    		 1 ↔ 1
    		 6(67729379-67751060)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.186902 Transcribed sequence with moderate similarity to protein more 72.25(n)    BX764850.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii med11 mediator complex subunit 1 61.91(n)
    63.12(a)    		   571519  XM_695117.5  XP_700209.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MED11 Mediator complex subunit 1 37.87(n)
    27.43(a)    		   40403  NM_141084.2  NP_649341.1 


    ENSEMBL Gene Tree for MED1 (if available)
    TreeFam Gene Tree for MED1 (if available) 

    Paralogs
    for MED1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MED1 gene
    CDSN2  

    MED1 for paralogs           About GeneDecksing



    Genomic Variants
    for MED1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/801 NCBI SNPs in MED1 are shown (see all 801)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1484767351,2
    		--37560537(+) GGCAAA/TTTACT 1 -- ds50010--------
    rs1924451071,2
    		--37560622(+) AGATTA/TCATCT 1 -- ut310--------
    rs1848720271,2
    		--37560623(+) GATTTA/CATCTA 1 -- ut310--------
    rs1887584881,2
    		C--37560662(+) ATTTAA/CAAAAC 1 -- ut310--------
    rs1897556321,2
    		--37560773(+) GTTCTC/TATAGC 1 -- ut310--------
    rs1816365401,2
    		--37560848(+) AAGGAC/TAGAAA 1 -- ut310--------
    rs1867724391,2
    		--37560864(+) GGGGGG/TCAGGG 1 -- ut310--------
    rs1426361741,2
    		--37560887(+) AGGAAA/CAAAAA 1 -- ut310--------
    rs1891871031,2
    		--37560932(+) TATACC/TGACAT 1 -- ut310--------
    rs1476183321,2
    		--37561021(+) CACTTA/CATTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MED1 (37560538 - 37607539 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MED1: --

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing MED1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED1
    DNA2.0 Custom Variant and Variant Library Synthesis for MED1

    Disorders / Diseases
    for MED1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MED1 for disorders           About GeneDecksing

    OMIM gene information: 604311    OMIM disorders: --

    20/32 diseases for MED1 (see all 32):    About MalaCards
    thyroiditis    otitis media    intractable epilepsy    haemophilus influenzae
    conjunctivitis    ataxia telangiectasia    sporadic breast cancer    gestational diabetes
    williams syndrome    rickets    diabetes mellitus    breast cancer
    alopecia    influenza    parkinson's disease    lung adenocarcinoma
    ataxia    ovarian carcinoma    alzheimer's disease    thyroid cancer

    3 Novoseek disease relationships for MED1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute otitis media 54.3 3 10853344 (2), 11876602 (1)
    breast cancer 20 11 10485914 (5), 19183483 (1), 15471764 (1)
    tumors 0 6 10485914 (2), 17229543 (1)

    Human Genome Epidemiology (HuGE) Navigator: MED1 (28 documents)

    Export disorders for MED1 gene to outside databases

    Publications
    for MED1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MED1 gene, integrated from 9 sources (see all 213):
    (articles sorted by number of sources associating them with MED1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. (PubMed id 10485914)1, 3, 9 Zhu Y....Reddy J.K. (1999)
    2. Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. (PubMed id 15471764)1, 2, 9 Wu Q.... Safe S. (2004)
    3. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. (PubMed id 9653119)1, 2, 9 Yuan C.-X.... Roeder R.G. (1998)
    4. Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. (PubMed id 10770935)1, 2, 9 Burakov D.... Freedman L.P. (2000)
    5. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. (PubMed id 12218053)1, 2, 9 Wang Q.... Fondell J.D. (2002)
    6. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. (PubMed id 14636573)1, 2, 9 Wallberg A.E.... Roeder R.G. (2003)
    7. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. (PubMed id 10733574)1, 2, 9 Rachez C....Freedman L.P. (2000)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. (PubMed id 16574658)1, 2 Udayakumar T.S.... Fondell J.D. (2006)

    External Searches for MED1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MED1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5469 HGNC: 9234 AceView: PPARBP Ensembl:ENSG00000125686 euGenes: HUgn5469
    ECgene: MED1 H-InvDB: MED1

    Other Databases showing MED1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MED1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MED1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MED1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MED1 gene:
    Search GeneIP for patents involving MED1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MED1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for MED1 (TRAP220)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MED1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MED1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MED1  
     OriGene Protein Over-expression Lysate for MED1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MED1   OriGene 3'-UTR Clone for MED1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MED1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MED1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MED1   OriGene Custom Protein Services for MED1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MED1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MED1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MED1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MED1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MED1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MED1
     GenScript Custom Purified and Recombinant Proteins Services for MED1 GenScript cDNA clones with any tag delivered in your preferred vector for MED1
     GenScript Custom Assay Services for MED1 GenScript Custom Superior Antibodies Services for MED1
     GenScript Custom overexpressing Cell Line Services for MED1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MED1 promoter
     Search Chromatin IP Primers for MED1
     RT2 qPCR Primer Assay in human, mouse, rat MED1
     GNC Network for MED1
     SABiosciences PCR Arrays including human, mouse, rat MED1
     Search Tocris compounds for MED1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Antibodies for MED1
     See all of Abcam's Antibodies, Kits and Proteins for MED1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MED1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MED1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MED1
     SwitchGear 3'UTR luciferase reporter plasmids for MED1
     SwitchGear Promoter luciferase reporter plasmids for MED1
     Search ThermoFisher Antibodies for MED1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MED1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MED1
    Sirion Biotech Customized:
     stable knockdown cell line services for MED1
     inducible knockdown cell line services for MED1
     design and validation of potent shRNA sequences against MED1
     adenovirus for potent knockdown of MED1
     adenovirus for overexpression of MED1
     stable overexpressing cell line services
     inducible overexpressing cell line services
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MED1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4