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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MECR Gene

protein-coding   GIFtS: 56
GCID: GC01M029519

mitochondrial trans-2-enoyl-CoA reductase
 Explore 3 diseases affiliated with
MECR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MECR    

Aliases
for MECR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitochondrial Trans-2-Enoyl-CoA Reductase1 2     Homolog Of Yeast 2-Enoyl Thioester Reductase2
NRBF11 2 5     HsNrbf-13
CGI-631 2     Mitochondrial 2-Enoyl Thioester Reductase2
FASN2B1 2     Nuclear Receptor Binding Factor 12
Nuclear Receptor-Binding Factor 12 3     Trans-2-Enoyl-CoA Reductase, Mitochondrial2
NRBF-12 3     HsNrbf-13
EC 1.3.1.383 8     NBRF13

External Ids:    HGNC: 196911   Entrez Gene: 511022   Ensembl: ENSG000001163537   OMIM: 6082055   UniProtKB: Q9BV793   

Export aliases for MECR gene to outside databases

Previous GC identifers: GC01M029341 GC01M029391 GC01M027771


Summaries
for MECR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an
NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial
synthesis of fatty acids

Gene Wiki entry for MECR


Genomic Views
for MECR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MECR gene promoter:
         AhR   PPAR-gamma1   NF-1   PPAR-gamma2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MECR promoter sequence
   Search SABiosciences Chromatin IP Primers for MECR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MECR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

MECR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MECR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M029519:  view genomic region     (about GC identifiers)

Start:
 29,519,385 bp from pter      End:
 29,557,454 bp from pter
Size:
 38,070 bases      Orientation:
 minus strand

Proteins
for MECR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79 (See protein sequence)
Recommended Name: Trans-2-enoyl-CoA reductase, mitochondrial precursor  
Size: 373 amino acids; 40462 Da
Subunit: Homodimer
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD34058.1; Type=Frameshift; Positions=14, 19;
2 PDB 3D structures from and Proteopedia for MECR:
1ZSY (3D)        2VCY (3D)    
Secondary accessions: B3KT72 Q5SYU0 Q5SYU1 Q5SYU2 Q6IBU9 Q9Y373
Alternative splicing: 2 isoforms:  Q9BV79-1   Q9BV79-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MECR: NX_Q9BV79

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BV79

    • 4 DME Specific Peptides for MECR (Q9BV79)
     PAVGGNE  PINPSDIN  GLGTWRTEAVF  SAATLGVNPCTAYRML 

    MECR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019903.1  NP_057095.2  

    ENSEMBL proteins: 
     ENSP00000362896   ENSP00000263702   ENSP00000436831   ENSP00000416960  

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    Uscn Proteins for MECR

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--


    MECR for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MECR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MECR for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BV79

    ProtoNet protein and cluster: Q9BV79

    1 Blocks protein family: IPB013154 Alcohol dehydrogenase GroES-like

    UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    Function
    for MECR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
    Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an
    NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial
    synthesis of fatty acids
    Catalytic activity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA; KM=7.1 uM for
    trans-2-decenoyl-CoA;

    Enzyme Number (IUBMB): EC 1.3.1.381 2

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: MECR 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0005102receptor binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity IDA12654921


    MECR for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MECR:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mecr):
     mortality/aging 

    MECR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MECR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Fatty Acid Biosynthesis
    		Fatty Acid Biosynthesis1.00
    2Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
    		Fatty acid elongation in mitochondria0.44
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MECR 
        Fatty Acid Biosynthesis


    2         Kegg Pathways  (Kegg details for MECR):
        Fatty acid elongation in mitochondria
    Metabolic pathways


    MECR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MECR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/74 Interacting proteins for MECR (Q9BV793 ENSP000002637024) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102763, ENSP000002540664I2D: score=2 STRING: ENSP00000254066
    PPARAQ078693, ENSP000002627354I2D: score=1 STRING: ENSP00000262735
    HNF4AP412353, ENSP000003129874I2D: score=1 STRING: ENSP00000312987
    RXRAP197933, ENSP000004196924I2D: score=1 STRING: ENSP00000419692
    THRBP108283, ENSP000003488274I2D: score=1 STRING: ENSP00000348827
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IDA12654921
    GO:0006633fatty acid biosynthetic process IEA--


    MECR for ontologies           About GeneDecksing



    Drugs & Compounds
    for MECR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MECR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MECR

    10/41 HMDB Compounds for MECR (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    1 Novoseek chemical compound relationship for MECR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 52.5 5 1892850 (2), 8089199 (1), 1815590 (1), 2021645 (1)

    Search CenterWatch for drugs/clinical trials and news about MECR 

    Transcripts
    for MECR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MECR gene (2 alternative transcripts): 
    NM_001024732.1  NM_016011.2  

    Unigene Cluster for MECR:

    Mitochondrial trans-2-enoyl-CoA reductase
    Hs.183646  [show with all ESTs]
    Unigene Representative Sequence: NM_001024732
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000373791(uc001brp.1 uc001brq.1 uc001brt.1) ENST00000475773
    ENST00000483435 ENST00000263702(uc010ofz.1) ENST00000473030 ENST00000478505
    ENST00000463412 ENST00000453185 ENST00000490529 ENST00000464511 ENST00000463052
    ENST00000489248 ENST00000475861 ENST00000472630 ENST00000474946 ENST00000464915
    ENST00000482610 ENST00000484012

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    hsa-miR-4271 hsa-miR-323-5p hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmid: MECR 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF151821.1 AK025830.1 AK095099.1 AK225687.1 AK226084.1 AK300889.1 AK315274.1 BC001419.2 
    CR456703.1 

    18 DOTS entries:

    DT.452328  DT.91763770  DT.100798959  DT.91763769  DT.91763771  DT.100798955  DT.95174118  DT.100798958 
    DT.100798953  DT.431671  DT.91763774  DT.95174117  DT.100798961  DT.121404917  DT.121404940  DT.99927194 
    DT.100798960  DT.91839251 

    24/182 AceView cDNA sequences (see all 182):

    AA449215 BM673220 CR624586 BU735019 BM696368 AA393872 AU099187 BG677456 
    AI354426 AA962664 CR616740 BM849428 BM665899 AA463768 R47992 AW005319 
    AI609046 BM762641 CR626137 BM762525 BI856447 BM673423 CR604427 BM981418 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MECR (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^
    SP1:                                      -     -     -     -     -     -     -     -     -     -     -     -                                                   
    SP2:                                      -     -     -     -     -     -     -     -     -     -     -                                                         
    SP3:                                      -     -     -     -     -     -     -     -                 -     -                                                   
    SP4:                                      -     -     -     -                 -     -                       -                                                   
    SP5:                                      -     -     -     -     -     -     -     -     -     -     -     -                                   -               

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:        -                           
    SP2:        -                           
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for MECR

    Expression
    for MECR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MECR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGGGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MECR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MECR

    SOURCE GeneReport for Unigene cluster: Hs.183646

    UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
    Tissue specificity: Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney
    and pancreas. Weakly or not expressed in lung

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    Orthologs
    for MECR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MECR gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mecr1 , 5 mitochondrial trans-2-enoyl-CoA reductase1, 5 82.66(n)1
    81.77(a)1    		   4 (64.52 cM)5
    269221  NM_025297.21  NP_079573.21 
     1318434705 
    chicken
    (Gallus gallus)    		 Aves MECR1 mitochondrial trans-2-enoyl-CoA reductase 67.37(n)
    64.85(a)    		   419601  XM_417748.3  XP_417748.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MECR6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343563.1(7322-13329)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.115272 Xenopus laevis transcribed sequence with weak similarity more 72.93(n)    CD253647.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.175832 Transcribed sequence with weak similarity to protein more 74.57(n)    CF995956.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG169351 CG16935 55.08(n)
    49.09(a)    		   36540  NM_137070.2  NP_610914.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea mecr-11 Protein MECR-1 50.67(n)
    47.08(a)    		   174963  NM_064399.2  NP_496800.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ETR1(YBR026C)4
    ETR11    		 2-enoyl thioester reductase, member of the medium chain more4
    Etr1p1    		 44.41(n)1
    39.03(a)1    		   2(294019-292877)4
    8523141, 4  NP_009582.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G457701 putative trans-2-enoyl-CoA reductase 52.66(n)
    46.45(a)    		   823720  NM_114446.3  NP_566881.1 
    rice
    (Oryza sativa)    		 Liliopsida Os11g01025001 hypothetical protein 52.76(n)
    51.66(a)    		   9272332  NM_001189367.1  NP_001176296.1 


    ENSEMBL Gene Tree for MECR (if available)
    TreeFam Gene Tree for MECR (if available) 

    Paralogs
    for MECR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MECR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/651 NCBI SNPs in MECR are shown (see all 651)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1438538851,2
    		--29518948(+) CCCCTA/GTGTGT 2 -- ds50010--------
    rs1403004101,2
    		--29519017(+) TCAATC/TTTGCA 2 -- ds50010--------
    rs1826526831,2
    		--29519018(+) CAATCC/TTGCAC 2 -- ds50010--------
    rs1873404181,2
    		--29519095(+) AGGCAA/CTCAAT 2 -- ds50010--------
    rs1926468231,2
    		--29519255(+) AAAGCC/TCACTC 2 -- ds50010--------
    rs1427237701,2
    		--29519271(+) TGAGAA/GCCCAC 2 -- ds50010--------
    rs1844890101,2
    		--29519302(+) AAGCAC/TACCCC 2 -- ds50010--------
    rs2013594281,2
    		C--29519426(+) ATCAAC/TGNNNN 2 -- ut310--------
    rs1474290631,2
    		--29519430(+) ACGACC/GTCATG 2 -- ut310--------
    rs1398037191,2
    		--29519440(+) GAACAC/TTGAAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MECR (29519385 - 29557454 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MECR: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MECR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MECR for disorders           About GeneDecksing

    OMIM gene information: 608205    OMIM disorders: --

    3 diseases for MECR:    About MalaCards
    complex partial epilepsy    blepharospasm    alcoholism

    1 disease from the University of Copenhagen DISEASES database for MECR:
    Blepharospasm
    Human Genome Epidemiology (HuGE) Navigator: MECR (1 document)

    Export disorders for MECR gene to outside databases

    Publications
    for MECR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MECR gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with MECR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II. (PubMed id 12654921)1, 2, 3, 9 Miinalainen I.J.... Hiltunen J.K. (2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    6. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. (PubMed id 9795230)1, 3 Masuda N....Osumi T. (1998)
    7. Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. (PubMed id 18479707)1, 9 Chen Z.J....Haapalainen A.M. (2008)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for MECR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MECR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51102 HGNC: 19691 AceView: CGI-63 Ensembl:ENSG00000116353 euGenes: HUgn51102
    ECgene: MECR Kegg: 51102 H-InvDB: MECR

    Other Databases showing MECR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MECR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MECR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MECR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MECR gene:
    Search GeneIP for patents involving MECR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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