Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MECR Gene

protein-coding   GIFtS: 62
GCID: GC01M029519

Mitochondrial Trans-2-Enoyl-CoA Reductase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Trans-2-Enoyl-CoA Reductase1 2     Homolog Of Yeast 2-Enoyl Thioester Reductase2
Mitochondrial 2-Enoyl Thioester Reductase1 2     Trans-2-Enoyl-CoA Reductase, Mitochondrial2
Nuclear Receptor Binding Factor 11 2     HsNrbf-13
EC 1.3.1.383 8     NBRF13
NRBF12 5     NRBF-13
CGI-632     Nuclear Receptor-Binding Factor 13
FASN2B2     

External Ids:    HGNC: 196911   Entrez Gene: 511022   Ensembl: ENSG000001163537   OMIM: 6082055   UniProtKB: Q9BV793   

Export aliases for MECR gene to outside databases

Previous GC identifers: GC01M029341 GC01M029391 GC01M027771


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MECR Gene: 
MECR (mitochondrial trans-2-enoyl-CoA reductase) is a protein-coding gene. Diseases associated with MECR include complex partial epilepsy, and blepharospasm, and among its related super-pathways are Metabolism and Biosynthesis of unsaturated fatty acids. GO annotations related to this gene include trans-2-enoyl-CoA reductase (NADPH) activity and nucleotide binding. An important paralog of this gene is VAT1.

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an
NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial
synthesis of fatty acids

Gene Wiki entry for MECR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MECR gene promoter:
         AhR   PPAR-gamma1   NF-1   PPAR-gamma2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMECR promoter sequence
   Search SABiosciences Chromatin IP Primers for MECR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MECR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

MECR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MECR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M029519:  view genomic region     (about GC identifiers)

Start:
29,519,385 bp from pter      End:
29,557,454 bp from pter
Size:
38,070 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79 (See protein sequence)
Recommended Name: Trans-2-enoyl-CoA reductase, mitochondrial precursor  
Size: 373 amino acids; 40462 Da
Subunit: Homodimer
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD34058.1; Type=Frameshift; Positions=14, 19;
2 PDB 3D structures from and Proteopedia for MECR:
1ZSY (3D)        2VCY (3D)    
Secondary accessions: B3KT72 Q5SYU0 Q5SYU1 Q5SYU2 Q6IBU9 Q9Y373
Alternative splicing: 2 isoforms:  Q9BV79-1   Q9BV79-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MECR: NX_Q9BV79

Explore proteomics data for MECR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BV79

  • 4 DME Specific Peptides for MECR (Q9BV79)
     PAVGGNE  PINPSDIN  GLGTWRTEAVF  SAATLGVNPCTAYRML 

    MECR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MECR Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001019903.2  NP_057095.3  

    ENSEMBL proteins: 
     ENSP00000362896   ENSP00000263702   ENSP00000436831  

    Human Recombinant Protein Products for MECR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MECR
    OriGene Protein Over-expression Lysate for MECR
    OriGene MassSpec for MECR 
    OriGene Custom Protein Services for MECR
    GenScript Custom Purified and Recombinant Proteins Services for MECR
    Novus Biologicals MECR Proteins
    Novus Biologicals MECR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MECR
    Cloud-Clone Corp. Proteins for MECR 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    MECR for ontologies           About GeneDecksing



    MECR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MECR
    GenScript Custom Superior Antibodies Services for MECR
    Novus Biologicals MECR Antibodies
    Abcam antibodies for MECR
    Cloud-Clone Corp. Antibodies for MECR 
    ThermoFisher Antibodies for MECR
    LSBio Antibodies in human, mouse, rat for MECR 

    Assay Products for MECR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MECR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MECR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MECR 
    Cloud-Clone Corp. CLIAs for MECR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BV79

    ProtoNet protein and cluster: Q9BV79

    1 Blocks protein domain: IPB013154 Alcohol dehydrogenase GroES-like

    UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    MECR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MECR_HUMAN, Q9BV79
    Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an
    NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial
    synthesis of fatty acids
    Catalytic activity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH
    Biophysicochemical properties: Kinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA; KM=7.1 uM for
    trans-2-decenoyl-CoA;

         Enzyme Number (IUBMB): EC 1.3.1.381 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
    GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity IDA12654921
         
    MECR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MECR:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mecr):
     mortality/aging 

    MECR for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MECR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MECR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MECR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MECR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MECR
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MECR:
    hsa-miR-4271 hsa-miR-323-5p hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidMECR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MECR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MECR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MECR
    Sirion Biotech Customized adenovirus for overexpression of MECR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MECR (see all 12)
    OriGene ORF clones in mouse, rat for MECR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MECR (NM_015365)
    Sino Biological Human cDNA Clone for MECR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MECR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECR
    Sirion Biotech Customized lentivirus for stable overexpression of MECR 
                         Customized lentivirus expression plasmids for stable overexpression of MECR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MECR
    Search LifeMap BioReagents cell lines for MECR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MECR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Biosynthesis of unsaturated fatty acids
    Fatty acid elongation0.38
    3Fatty Acid Biosynthesis
    Fatty Acid Biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MECR
        Fatty Acid Biosynthesis



    2         Kegg Pathways  (Kegg details for MECR):
        Fatty acid elongation
    Metabolic pathways


    MECR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MECR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/74 Interacting proteins for MECR (Q9BV793 ENSP000002637024) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102763, ENSP000002540664I2D: score=2 STRING: ENSP00000254066
    PPARAQ078693, ENSP000002627354I2D: score=1 STRING: ENSP00000262735
    HNF4AP412353, ENSP000003129874I2D: score=1 STRING: ENSP00000312987
    RXRAP197933, ENSP000004196924I2D: score=1 STRING: ENSP00000419692
    THRBP108283, ENSP000003488274I2D: score=1 STRING: ENSP00000348827
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IDA12654921
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0055114oxidation-reduction process ----

    MECR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MECR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MECR

    10/41 HMDB Compounds for MECR (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----

    1 Novoseek inferred chemical compound relationship for MECR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 52.5 5 1892850 (2), 8089199 (1), 1815590 (1), 2021645 (1)

    Search CenterWatch for drugs/clinical trials and news about MECR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MECR gene (2 alternative transcripts): 
    NM_001024732.2  NM_016011.3  

    Unigene Cluster for MECR:

    Mitochondrial trans-2-enoyl-CoA reductase
    Hs.183646  [show with all ESTs]
    Unigene Representative Sequence: NM_001024732
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373791(uc001brp.1 uc001brq.1 uc001brt.1) ENST00000475773
    ENST00000483435 ENST00000263702(uc010ofz.1) ENST00000473030 ENST00000463412
    ENST00000453185 ENST00000478505 ENST00000490529 ENST00000464511 ENST00000463052
    ENST00000489248 ENST00000475861 ENST00000474946 ENST00000464915 ENST00000482610
    ENST00000484012 ENST00000493928
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MECR
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MECR:
    hsa-miR-4271 hsa-miR-323-5p hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidMECR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MECR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MECR
    Clone
    Products:
         
    OriGene clones in human, mouse for MECR (see all 12)
    OriGene ORF clones in mouse, rat for MECR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MECR (NM_015365)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MECR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECR
    Sirion Biotech Customized lentivirus for stable overexpression of MECR 
                         Customized lentivirus expression plasmids for stable overexpression of MECR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MECR
    OriGene qSTAR qPCR primer pairs in human, mouse for MECR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MECR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MECR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MECR

    Additional mRNA sequence: 

    AF151821.1 AK025830.1 AK095099.1 AK225687.1 AK226084.1 AK300889.1 AK315274.1 BC001419.2 
    CR456703.1 

    18 DOTS entries:

    DT.452328  DT.91763770  DT.100798959  DT.91763769  DT.91763771  DT.100798955  DT.95174118  DT.100798958 
    DT.100798953  DT.431671  DT.91763774  DT.95174117  DT.100798961  DT.121404917  DT.121404940  DT.99927194 
    DT.100798960  DT.91839251 

    24/182 AceView cDNA sequences (see all 182):

    BM762525 BU735019 AI609046 CR604427 AW005319 BM673423 AA962664 AA463768 
    AA449215 BM665899 BM981418 AA393872 CR626137 CR624586 AI354426 BM673220 
    BG677456 AU099187 CB306099 BM849428 BM696368 BM762641 CR616740 R47992 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MECR (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^
    SP1:                                      -     -     -     -     -     -     -     -     -     -     -     -                                                   
    SP2:                                      -     -     -     -     -     -     -     -     -     -     -                                                         
    SP3:                                      -     -     -     -     -     -     -     -                 -     -                                                   
    SP4:                                      -     -     -     -                 -     -                       -                                                   
    SP5:                                      -     -     -     -     -     -     -     -     -     -     -     -                                   -               

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:        -                           
    SP2:        -                           
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for MECR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MECR expression in normal human tissues (normalized intensities)      MECR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGGAGG
    MECR Expression
    About this image


    MECR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See MECR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MECR

    SOURCE GeneReport for Unigene cluster: Hs.183646

    UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
    Tissue specificity: Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver,
    kidney and pancreas. Weakly or not expressed in lung

        SABiosciences Custom PCR Arrays for MECR
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MECR
    OriGene qSTAR qPCR primer pairs in human, mouse for MECR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MECR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MECR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MECR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MECR gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mecr1 , 5 mitochondrial trans-2-enoyl-CoA reductase1, 5 82.66(n)1
    81.77(a)1
      4 (64.52 cM)5
    269221  NM_025297.21  NP_079573.21 
     1318434705 
    chicken
    (Gallus gallus)
    Aves MECR1 mitochondrial trans-2-enoyl-CoA reductase 67.37(n)
    64.85(a)
      419601  XM_417748.3  XP_417748.3 
    lizard
    (Anolis carolinensis)
    Reptilia MECR6
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343563.1(6059-13383)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115272 Xenopus laevis transcribed sequence with weak similarity more 72.93(n)    CD253647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.175832 Transcribed sequence with weak similarity to protein more 74.57(n)    CF995956.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169351 CG16935 55.08(n)
    49.09(a)
      36540  NM_137070.2  NP_610914.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mecr-11 Protein MECR-1 50.67(n)
    47.08(a)
      174963  NM_064399.2  NP_496800.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ETR1(YBR026C)4
    ETR11
    2-enoyl thioester reductase, member of the medium chain more4
    Etr1p1
    44.41(n)1
    39.03(a)1
      2(294019-292877)4
    8523141, 4  NP_009582.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G457701 putative trans-2-enoyl-CoA reductase 52.66(n)
    46.45(a)
      823720  NM_114446.3  NP_566881.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g01025001 hypothetical protein 52.76(n)
    51.66(a)
      9272332  NM_001189367.1  NP_001176296.1 


    ENSEMBL Gene Tree for MECR (if available)
    TreeFam Gene Tree for MECR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MECR gene
    VAT12  VAT1L2  CRYZ2  TP53I32  

    MECR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/779 SNPs in MECR are shown (see all 779)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438538851,2
    C--29518948(+) CCCCTA/GTGTGT 2 -- ds50010--------
    rs1403004101,2
    --29519017(+) TCAATC/TTTGCA 2 -- ds50010--------
    rs1826526831,2
    --29519018(+) CAATCC/TTGCAC 2 -- ds50010--------
    rs1873404181,2
    --29519095(+) AGGCAA/CTCAAT 2 -- ds50010--------
    rs1926468231,2
    --29519255(+) AAAGCC/TCACTC 2 -- ds50010--------
    rs1427237701,2
    --29519271(+) TGAGAA/GCCCAC 2 -- ds50010--------
    rs1844890101,2
    --29519302(+) AAGCAC/TACCCC 2 -- ds50010--------
    rs2013594281,2
    C--29519426(+) ATCAAC/TGNNNN 2 -- ut310--------
    rs1474290631,2
    --29519430(+) ACGACC/GTCATG 2 -- ut310--------
    rs1398037191,2
    C--29519440(+) GAACAC/TTGAAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MECR (29519385 - 29557454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MECR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871249CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MECR
    DNA2.0 Custom Variant and Variant Library Synthesis for MECR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608205    OMIM disorders: --

    3 diseases for MECR:    About MalaCards
    complex partial epilepsy    blepharospasm    alcoholism

    1 disease from the University of Copenhagen DISEASES database for MECR:
    Blepharospasm

    MECR for disorders           About GeneDecksing

    Genetic Association Database (GAD): MECR
    Human Genome Epidemiology (HuGE) Navigator: MECR (1 document)

    Export disorders for MECR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MECR gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with MECR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II. (PubMed id 12654921)1, 2, 3, 9 Miinalainen I.J.... Hiltunen J.K. (2003)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    7. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. (PubMed id 9795230)1, 3 Masuda N....Osumi T. (1998)
    8. Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. (PubMed id 18479707)1, 9 Chen Z.J....Haapalainen A.M. (2008)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51102 HGNC: 19691 AceView: CGI-63 Ensembl:ENSG00000116353 euGenes: HUgn51102
    ECgene: MECR Kegg: 51102 H-InvDB: MECR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MECR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MECR gene:
    Search GeneIP for patents involving MECR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MECR  
     OriGene qPCR primer pairs and template standards for MECR   OriGene Protein Over-expression Lysate for MECR  
     OriGene MassSpec something-or-other for MECR   OriGene clones in human, mouse for MECR  
     OriGene qSTAR qPCR primer pairs in human, mouse for MECR   OriGene Purified Protein for MECR  
     OriGene ORF clones in mouse, rat for MECR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MECR   OriGene Custom Protein Services for MECR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MECR
     QIAGEN SeqTarget long-range PCR primers for resequencing MECR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MECR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MECR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MECR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MECR
     GenScript Custom Purified and Recombinant Proteins Services for MECR GenScript cDNA clones with any tag delivered in your preferred vector for MECR
     GenScript Custom Assay Services for MECR GenScript Custom Superior Antibodies Services for MECR
     GenScript Custom overexpressing Cell Line Services for MECR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MECR promoter
     Search Chromatin IP Primers for MECR
     RT2 qPCR Primer Assay in human, mouse, rat MECR
     Search GNC Networks for MECR
     SABiosciences Custom PCR Arrays for MECR
     Search Tocris compounds for MECR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for MECR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MECR antibodies
     MECR proteins
     MECR lysates
     Antibodies for MECR
     See all of Abcam's Antibodies, Kits and Proteins for MECR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MECR




     Proteins for MECR
     Antibodies for MECR
     ELISAs for MECR
     CLIAs for MECR
     Search LifeMap BioReagents cell lines for MECR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECR
     SwitchGear 3'UTR luciferase reporter plasmids for MECR
     SwitchGear Promoter luciferase reporter plasmids for MECR
     ThermoFisher Antibodies for MECR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MECR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MECR
    Customized:
     lentivirus for stable overexpression of MECR
     lentivirus expression plasmids for stable overexpression of MECR
     adenovirus for overexpression of MECR
     LSBio Antibodies in human, mouse, rat for MECR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MECR gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4