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Aliases for MECR Gene

Aliases for MECR Gene

  • Mitochondrial Trans-2-Enoyl-CoA Reductase 2 3
  • Mitochondrial 2-Enoyl Thioester Reductase 2 3
  • Nuclear Receptor Binding Factor 1 2 3
  • EC 1.3.1.38 4 64
  • NRBF1 3 6
  • Homolog Of Yeast 2-Enoyl Thioester Reductase 3
  • Trans-2-Enoyl-CoA Reductase, Mitochondrial 3
  • Nuclear Receptor-Binding Factor 1 4
  • HsNrbf-1 4
  • CGI-63 3
  • FASN2B 3
  • NRBF-1 4
  • NBRF1 4

External Ids for MECR Gene

Summaries for MECR Gene

GeneCards Summary for MECR Gene

MECR (Mitochondrial Trans-2-Enoyl-CoA Reductase) is a Protein Coding gene. Diseases associated with MECR include blepharospasm. Among its related pathways are Metabolism and Fatty acid metabolism. GO annotations related to this gene include trans-2-enoyl-CoA reductase (NADPH) activity.

UniProtKB/Swiss-Prot for MECR Gene

  • Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.

Gene Wiki entry for MECR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MECR Gene

Genomics for MECR Gene

Genomic Location for MECR Gene

Start:
29,192,657 bp from pter
End:
29,230,958 bp from pter
Size:
38,302 bases
Orientation:
Minus strand

Genomic View for MECR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MECR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MECR Gene

Regulatory Elements for MECR Gene

Proteins for MECR Gene

  • Protein details for MECR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV79-MECR_HUMAN
    Recommended name:
    Trans-2-enoyl-CoA reductase, mitochondrial
    Protein Accession:
    Q9BV79
    Secondary Accessions:
    • B3KT72
    • Q5SYU0
    • Q5SYU1
    • Q5SYU2
    • Q6IBU9
    • Q9Y373

    Protein attributes for MECR Gene

    Size:
    373 amino acids
    Molecular mass:
    40462 Da
    Quaternary structure:
    • Homodimer. Isoform 2 interacts with PPARA in the nucleus and increases its activity.
    SequenceCaution:
    • Sequence=AAD34058.1; Type=Frameshift; Positions=14, 19; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MECR Gene

    Alternative splice isoforms for MECR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MECR Gene

Proteomics data for MECR Gene at MOPED

Selected DME Specific Peptides for MECR Gene

Post-translational modifications for MECR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MECR Gene

Domains for MECR Gene

Protein Domains for MECR Gene

UniProtKB/Swiss-Prot:

MECR_HUMAN
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.:
    • Q9BV79
genes like me logo Genes that share domains with MECR: view

No data available for Gene Families for MECR Gene

Function for MECR Gene

Molecular function for MECR Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707}; KM=7.1 uM for trans-2-decenoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707}; KM=3.6 uM for trans-dodec-2-enoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707}; KM=10.4 uM for trans-dec-2-enoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707}; KM=10.2 uM for trans-oct-2-enoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707}; KM=4.3 uM for trans-tetradec-2-enoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707}; KM=6.6 uM for trans-hexadec-2-enoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707}; KM=63.5 uM for trans-hex-2-enoyl-CoA {ECO:0000269 PubMed:12654921, ECO:0000269 PubMed:18479707};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function: Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.

Enzyme Numbers (IUBMB) for MECR Gene

Gene Ontology (GO) - Molecular Function for MECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity IDA 12654921
genes like me logo Genes that share ontologies with MECR: view

Phenotypes for MECR Gene

MGI mutant phenotypes for MECR:
inferred from 1 alleles
GenomeRNAi human phenotypes for MECR:
genes like me logo Genes that share phenotypes with MECR: view

miRNA for MECR Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MECR Gene

Localization for MECR Gene

Subcellular locations from UniProtKB/Swiss-Prot for MECR Gene

Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MECR Gene COMPARTMENTS Subcellular localization image for MECR gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with MECR: view

Pathways for MECR Gene

genes like me logo Genes that share pathways with MECR: view

Pathways by source for MECR Gene

1 BioSystems pathway for MECR Gene

Gene Ontology (GO) - Biological Process for MECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IDA 12654921
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MECR: view

Compounds for MECR Gene

(41) HMDB Compounds for MECR Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(1) Novoseek inferred chemical compound relationships for MECR Gene

Compound -log(P) Hits PubMed IDs
progesterone 52.5 5
genes like me logo Genes that share compounds with MECR: view

Transcripts for MECR Gene

Unigene Clusters for MECR Gene

Mitochondrial trans-2-enoyl-CoA reductase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MECR Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - -
SP12: - - - -
SP13: - - - - - - - - - -
SP14: - - -
SP15: - - - -
SP16:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MECR Gene

GeneLoc Exon Structure for
MECR
ECgene alternative splicing isoforms for
MECR

Expression for MECR Gene

mRNA expression in normal human tissues for MECR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MECR Gene

SOURCE GeneReport for Unigene cluster for MECR Gene Hs.183646

mRNA Expression by UniProt/SwissProt for MECR Gene

Q9BV79-MECR_HUMAN
Tissue specificity: Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.
genes like me logo Genes that share expressions with MECR: view

Orthologs for MECR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MECR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MECR 36
  • 99.82 (n)
  • 99.46 (a)
MECR 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MECR 36
  • 87.22 (n)
  • 84.72 (a)
MECR 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MECR 36
  • 88.89 (n)
  • 87.16 (a)
MECR 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mecr 36
  • 82.66 (n)
  • 82.04 (a)
Mecr 16
Mecr 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MECR 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 62 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mecr 36
  • 83.02 (n)
  • 81.5 (a)
chicken
(Gallus gallus)
Aves MECR 36
  • 67.34 (n)
  • 66.33 (a)
MECR 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MECR 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11527 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mecr 36
  • 63.94 (n)
  • 64.85 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17583 36
mecr 36
  • 64.84 (n)
  • 64.74 (a)
mecr 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011834 36
  • 55.59 (n)
  • 49.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16935 36
  • 55.93 (n)
  • 50.77 (a)
CG16935 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mecr-1 36
  • 50.66 (n)
  • 46.79 (a)
mecr-1 37
  • 44 (a)
OneToMany
Y48A6B.9 37
  • 40 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL081W 36
  • 49.04 (n)
  • 41.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ETR1 36
  • 44.33 (n)
  • 38.94 (a)
ETR1 37
  • 31 (a)
OneToOne
ETR1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24552g 36
  • 47.51 (n)
  • 40.86 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45770 36
  • 53.09 (n)
  • 46.81 (a)
rice
(Oryza sativa)
Liliopsida Os11g0102500 36
  • 53.57 (n)
  • 52.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00655 36
  • 52.02 (n)
  • 42.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes etr1 36
  • 50.31 (n)
  • 44.65 (a)
Species with no ortholog for MECR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MECR Gene

ENSEMBL:
Gene Tree for MECR (if available)
TreeFam:
Gene Tree for MECR (if available)

Paralogs for MECR Gene

No data available for Paralogs for MECR Gene

Variants for MECR Gene

Sequence variations from dbSNP and Humsavar for MECR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3222 -- 29,192,209(+) ATCTG(G/T)ACCTC downstream-variant-500B
rs903045 -- 29,201,900(-) CACAT(C/G)TCCCT intron-variant
rs1021461 -- 29,202,141(-) AAAAA(A/G)AAGCA intron-variant
rs1062924 -- 29,203,187(-) CAAGC(A/G)GTCAT reference, synonymous-codon
rs1128400 - 29,216,125(-) ACGGA(C/T)TCCTT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MECR Gene

Variant ID Type Subtype PubMed ID
nsv871249 CNV Gain 21882294

Relevant External Links for MECR Gene

HapMap Linkage Disequilibrium report
MECR

Disorders for MECR Gene

(1) MalaCards Diseases for MECR Gene

Search for MECR Gene in MalaCards »

(1) University of Copenhagen DISEASES for MECR Gene

Relevant External Links for MECR

Genetic Association Database (GAD)
MECR
Human Genome Epidemiology (HuGE) Navigator
MECR
genes like me logo Genes that share disorders with MECR: view

No data available for UniProtKB/Swiss-Prot for MECR Gene

Publications for MECR Gene

  1. Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II. (PMID: 12654921) Miinalainen I.J. … Hiltunen J.K. (J. Biol. Chem. 2003) 2 3 4 23
  2. Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. (PMID: 18479707) Chen Z.J. … Haapalainen A.M. (J. Mol. Biol. 2008) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for MECR Gene

Sources for MECR Gene

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