Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MECP2 Gene

protein-coding   GIFtS: 68
GCID: GC0XM153287

Methyl CpG Binding Protein 2 (Rett Syndrome)

(Previous names: mental retardation, X-linked 16, mental retardation, X-linked...)
(Previous symbols: RTT, MRX16, MRX79)
  See MECP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Methyl CpG Binding Protein 2 (Rett Syndrome)1 2     PPMX2 5
MRX161 2 5     Mental Retardation, X-Linked 161
MRX791 2 5     Mental Retardation, X-Linked 791
RTT1 2 5     RS2
MeCp-2 Protein2 3     RTS2
AUTSX32 5     Methyl-CpG-Binding Protein 22
MRXS132 5     MeCp23
MRXSL2 5     

External Ids:    HGNC: 69901   Entrez Gene: 42042   Ensembl: ENSG000001690577   OMIM: 3000055   UniProtKB: P516083   

Export aliases for MECP2 gene to outside databases

Previous GC identifers: GC0XM147424 GC0XM149742 GC0XM150872 GC0XM151755 GC0XM152808 GC0XM152940 GC0XM141928


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MECP2 Gene:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian
development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by
the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is
capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from
methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X
inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene
mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one
of the most common causes of mental retardation in females. (provided by RefSeq, Jul 2009)

GeneCards Summary for MECP2 Gene:
MECP2 (methyl CpG binding protein 2 (Rett syndrome)) is a protein-coding gene. Diseases associated with MECP2 include autism susceptibility, x-linked 3, and bruxism. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MBD4.

UniProtKB/Swiss-Prot: MECP2_HUMAN, P51608
Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair.
It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through
interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and
5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity)

Gene Wiki entry for MECP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MECP2 gene promoter:
         TBP   ISGF-3   Nkx2-5   IRF-1   STAT5A   NF-Y   CBF(2)   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MECP2 promoter sequence
   Search Chromatin IP Primers for MECP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MECP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MECP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MECP2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153287:  view genomic region     (about GC identifiers)

Start:
153,287,024 bp from pter      End:
153,363,212 bp from pter
Size:
76,189 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MECP2_HUMAN, P51608 (See protein sequence)
Recommended Name: Methyl-CpG-binding protein 2  
Size: 486 amino acids; 52441 Da
Subunit: Interacts with FNBP3 (By similarity). Interacts with CDKL5
Sequence caution: Sequence=CAD97991.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for MECP2:
1QK9 (3D)        3C2I (3D)    
Secondary accessions: O15233 Q6QHH9 Q7Z384
Alternative splicing: 2 isoforms:  P51608-1   P51608-2   (Ten times higher expression levels than isoform A in brain)

Explore the universe of human proteins at neXtProt for MECP2: NX_P51608

Explore proteomics data for MECP2 at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to
    regulate dendritic growth and spine maturation (By similarity)1
  • Ubiquitination2 at Lys130
  • Modification sites at PhosphoSitePlus

  • See MECP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001104262.1  NP_004983.1  

    ENSEMBL proteins: 
     ENSP00000301948   ENSP00000395535   ENSP00000384865   ENSP00000358973   ENSP00000416267  

    MECP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MECP2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MECP2
    GenScript Custom Purified and Recombinant Proteins Services for MECP2
    Novus Biologicals MECP2 Proteins
    Novus Biologicals MECP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MECP2
    Cloud-Clone Corp. Proteins for MECP2

     
    Search eBioscience for Proteins for MECP2 

     
    antibodies-online proteins for MECP2 (11 products) 

     
    antibodies-online peptides for MECP2

    MECP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MECP2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MECP2 
    OriGene Antibodies for MECP2
    OriGene Custom Antibody Services for MECP2
    Novus Biologicals MECP2 Antibodies
    Abcam antibodies for MECP2
    Cloud-Clone Corp. Antibodies for MECP2
    ThermoFisher Antibody for MECP2
    antibodies-online antibodies for MECP2 (118 products) 

    MECP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MECP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MECP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MECP2
    Cloud-Clone Corp. CLIAs for MECP2
    Search eBioscience for ELISAs for MECP2 
    antibodies-online kits for MECP2 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR017956 AT_hook_DNA-bd_motif
     IPR001739 Methyl_CpG_DNA-bd
     IPR017353 Me_CpG-bd_MeCP2
     IPR016177 DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P51608

    ProtoNet protein and cluster: P51608

    1 Blocks protein domain: IPB001739 Methyl-CpG binding

    UniProtKB/Swiss-Prot: MECP2_HUMAN, P51608
    Similarity: Contains 2 A.T hook DNA-binding domains
    Similarity: Contains 1 MBD (methyl-CpG-binding) domain


    Find genes that share domains with MECP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MECP2_HUMAN, P51608
    Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair.
    It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through
    interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and
    5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity)

         Genatlas biochemistry entry for MECP2:
    methyl CpG-binding protein 2,abundant chromosomal protein,murine Mecp2 homolog,that selectivity binds 5'methyl
    cytosine residues in symmetrically positioned GpG dinucleotides,preferentially in the promoter regions of genes
    subject to transcriptional silencing after DNA methylation,interacting with histone deacetylase and the
    transcriptional corepressor SIN3A,involved in the regulation of gene expression

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9620804
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS10773092
    GO:0003729mRNA binding IEA--
         
    Find genes that share ontologies with MECP2           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 24 alleles(MGI details for Mecp2) (see all 20):
     adipose tissue  behavior/neurological  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with MECP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MECP2: Mecp2tm1Pplt Mecp2tm1.1Jae Mecp2tm1Jchr Mecp2tm1Hzo Mecp2tm1.1Bird

       genOway: Develop your customized and physiologically relevant rodent model for MECP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MECP2:
    hsa-mir-155-5p (MIRT000442), hsa-mir-148b-3p (MIRT019389), hsa-mir-212-3p (MIRT003897), hsa-mir-124-3p (MIRT007282), hsa-mir-122-5p (MIRT003089), hsa-mir-19a-3p (MIRT001795), hsa-mir-199a-3p (MIRT000779), hsa-mir-92a-3p (MIRT049717), hsa-mir-425-3p (MIRT042431), hsa-mir-195-5p (MIRT000795), hsa-mir-802 (MIRT000441), hsa-mir-199a-5p (MIRT004395), hsa-mir-331-3p (MIRT043437)

    Block miRNA regulation of human, mouse, rat MECP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MECP2 (see all 100):
    hsa-miR-194* hsa-miR-548j hsa-miR-520f hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MECP2
    Predesigned siRNA for gene silencing in human, mouse, rat MECP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MECP2

    Clone
    Products:
         
    OriGene clones in human, mouse for MECP2 (see all 12)
    OriGene ORF clones in mouse, rat for MECP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MECP2 (NM_004992)
    Sino Biological Human cDNA Clone for MECP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MECP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECP2
    Addgene plasmids for MECP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MECP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MECP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MECP2_HUMAN, P51608: Nucleus. Note=Colocalized with methyl-CpG in the genome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000792heterochromatin IDA11441023
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--

    Find genes that share ontologies with MECP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MECP2 About    
    See pathways by source

    SuperPathContained pathways About
    1GABA signaling in brain
    GABA signaling in brain0.32
    2Macrophage Differentiation and Growth Inhibition by METS
    DNA Methylation and Transcriptional Repression0.30
    3SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    4Neuroscience
    Neuroscience
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with MECP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MECP2
        DNA Methylation and Transcriptional Repression

    2 Cell Signaling Technology (CST) Pathways for MECP2
        Chromatin Regulation / Acetylation
    Neuroscience

    1 BioSystems Pathway for MECP2
        SIDS Susceptibility Pathways



        Pathway & Disease-focused RT2 Profiler PCR Array including MECP2: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MECP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MECP2 (P516081, 2, 3 ENSP000003955354) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK2Q9H2X61, 2, 3EBI-1189067,EBI-348345 MINT-7308929 MINT-7308914 I2D: score=1 
    SMARCA2P515311, 3, ENSP000002657734EBI-1189067,EBI-679562 I2D: score=5 STRING: ENSP00000265773
    HIST2H3AQ71DI33, ENSP000003854794I2D: score=1 STRING: ENSP00000385479
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9620804
    GO:0001662behavioral fear response IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001964startle response IEA--
    GO:0001976neurological system process involved in regulation of systemic arterial blood pressure IEA--

    Find genes that share ontologies with MECP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MECP2

    Selected Novoseek inferred chemical compound relationships for MECP2 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 64.5 2 15247904 (1), 16848908 (1)
    cytosine 53.2 3 10390525 (1), 10319871 (1), 18313390 (1)
    5-methylcytosine 41.6 6 11331619 (1), 15917437 (1), 17309881 (1)
    hpaii 17.5 2 11691937 (2)
    azathioprine 13.9 1 17036333 (1)
    valproate 6.55 1 15870696 (1)
    gaba 6.37 5 17363207 (1), 18302128 (1)
    folate 3.82 5 18058624 (1), 12939425 (1)
    oligonucleotide 0 2 19324899 (1), 15689352 (1)
    guanosine 0 3 11453972 (1)



    Find genes that share compounds with MECP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MECP2 gene (2 alternative transcripts): 
    NM_001110792.1  NM_004992.3  

    Unigene Cluster for MECP2:

    Methyl CpG binding protein 2 (Rett syndrome)
    Hs.200716  [show with all ESTs]
    Unigene Representative Sequence: GQ203295
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303391(uc004fjv.2 uc004fjw.2) ENST00000453960 ENST00000407218
    ENST00000486506 ENST00000369957 ENST00000496908 ENST00000481807 ENST00000463644
    ENST00000460227 ENST00000415944 ENST00000488293
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MECP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MECP2 (see all 100):
    hsa-miR-194* hsa-miR-548j hsa-miR-520f hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-218-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MECP2
    Predesigned siRNA for gene silencing in human, mouse, rat MECP2
    Clone
    Products:
         
    OriGene clones in human, mouse for MECP2 (see all 12)
    OriGene ORF clones in mouse, rat for MECP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MECP2 (NM_004992)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MECP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECP2
    Addgene plasmids for MECP2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MECP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MECP2
      QuantiTect SYBR Green Assays in human, mouse, rat MECP2
      QuantiFast Probe-based Assays in human, mouse, rat MECP2

    Additional mRNA sequence: 

    AB209464.1 AF158180.1 AJ132917.1 AK289444.1 AY541280.1 BC011612.1 BX538060.1 DQ656049.2 
    GQ203293.1 GQ203294.1 GQ203295.1 GQ896382.1 GU479943.1 GU812285.1 GU812286.1 HM020402.1 
    HM156732.1 HM156733.1 HQ127345.1 HQ141377.1 HQ141378.1 L37298.1 X89430.1 X99686.1 
    Y12643.1 

    13 DOTS entries:

    DT.92046808  DT.92434186  DT.453173  DT.100730813  DT.100798087  DT.92434188  DT.100798090  DT.100831459 
    DT.121294059  DT.75101285  DT.86846848  DT.91868594  DT.121294031 

    Selected AceView cDNA sequences (see all 269):

    BI821242 BM850695 BU621700 CA436384 BM696151 CK821012 AI955326 BQ681323 
    BU679576 AL157555 AI439398 R09924 CD516820 AA888593 BU678549 BX509998 
    BC011612 CB242738 AA351289 BM986904 BQ067965 BG741923 N26870 AA543089 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MECP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:        -           -               
    SP2:        -     -     -               
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for MECP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MECP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGGCCAA
    MECP2 Expression
    About this image


    MECP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MECP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MECP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200716

    UniProtKB/Swiss-Prot: MECP2_HUMAN, P51608
    Tissue specificity: Present in all adult somatic tissues tested

        Pathway & Disease-focused RT2 Profiler PCR Array including MECP2: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MECP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MECP2
    QuantiTect SYBR Green Assays in human, mouse, rat MECP2
    QuantiFast Probe-based Assays in human, mouse, rat MECP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for MECP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mecp21 , 5 methyl CpG binding protein 21, 5 90.15(n)1
    94.83(a)1
      X (37.63 cM)5
    172571  NM_010788.31  NP_034918.11 
     740265925 
    lizard
    (Anolis carolinensis)
    Reptilia MECP26
    methyl CpG binding protein 2 (Rett syndrome)
    66(a)
    1 ↔ 1
    2(88474297-88595647)
    African clawed frog
    (Xenopus laevis)
    Amphibia MECP22 methyl-CpG-binding protein MeCP2 76.69(n)    AF106951.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk96a042 Danio rerio methyl-cytosine binding protein 2 (mecp2) more 74.06(n)    AY298900.2 


    ENSEMBL Gene Tree for MECP2 (if available)
    TreeFam Gene Tree for MECP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MECP2 gene
    MBD42  
    1 SIMAP similar gene for MECP2 using alignment to 17 protein entries:     MECP2_HUMAN (see all proteins):
    MBD4

    Find genes that share paralogs with MECP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MECP2 (see all 1574)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289354681,2,,4
    CRett syndrome (RTT)4 pathogenic1153164502(-) AGAAGC/TGCAAG 6 R C mis1 ese32Minor allele frequency- T:0.00NA 4
    rs289349061,2,,4
    CRett syndrome (RTT)4 pathogenic1153164945(-) CTTCAC/TGGTAA 6 T M mis1 ese32Minor allele frequency- T:0.00NA 4
    rs289349051,2,,4
    CRett syndrome (RTT)4 pathogenic1153164954(-) TGATTC/G/TTGACT 9 S C F mis10--------
    rs289349081,2,,4
    CMental retardation, X-linked, syndromic, 13 (MRXS13)4 pathogenic1153164999(-) GATTGC/TGTACT 6 A V mis1 ese30--------
    rs289349041,2,,4
    CRett syndrome (RTT)4 pathogenic1153165021(-) CCTTTC/G/TGCTCT 9 R G C mis12NA 4
    rs289349071,2,,4
    CRett syndrome (RTT)4 pathogenic1153165858(-) GGACAC/G/TGGAAG 9 R G W mis1 ese32NA 4
    rs289351681,2,,4
    CRett syndrome (RTT)4 pathogenic1153165876(-) CCACCC/GTGCCT 6 L V mis1 ese30--------
    VAR_0182064
    Rett syndrome (RTT)4--see VAR_0182062 P A mis40--------
    VAR_0235574
    Rett syndrome (RTT)4--see VAR_0235572 T A mis40--------
    VAR_0376654
    Mental retardation, X-linked, syndromic, 13 (MRXS13)4--see VAR_0376652 P S mis40--------

    HapMap Linkage Disequilibrium report for MECP2 (153287024 - 153363212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MECP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517994CNV Gain19592680
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): MECP2
    Locus Specific Mutation Databases (LSDB): MECP2

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing MECP2:
    Intellectual Disability
    SeqTarget long-range PCR primers for resequencing MECP2
    DNA2.0 Custom Variant and Variant Library Synthesis for MECP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300005   
    OMIM disorders: 312750  300055  300673  300496  105830  300260  
    UniProtKB/Swiss-Prot: MECP2_HUMAN, P51608
  • Angelman syndrome (AS) [MIM:105830]: A neurodevelopmental disorder characterized by severe motor and
    intellectual retardation, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia,
    seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, open-mouthed expression
    revealing the tongue. Note=The disease may be caused by mutations affecting the gene represented in this entry
  • Mental retardation, X-linked, syndromic, 13 (MRXS13) [MIM:300055]: A disorder characterized by
    significantly below average general intellectual functioning associated with impairments in adaptive behavior and
    manifested during the developmental period. MRXS13 patients manifest mental retardation associated with other
    variable features such as spasticity, episodes of manic depressive psychosis, increased tone and macroorchidism.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Rett syndrome (RTT) [MIM:312750]: An X-linked dominant neurodevelopmental disorder, and one of the most
    common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age,
    then gradually lose speech and purposeful hand movements, and develop microcephaly, seizures, autism, ataxia,
    mental retardation and stereotypic hand movements. After initial regression, the condition stabilizes and
    patients usually survive into adulthood. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Autism, X-linked 3 (AUTSX3) [MIM:300496]: A complex multifactorial, pervasive developmental disorder
    characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped
    patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most
    individuals with autism also manifest moderate mental retardation. Note=The disease may be caused by mutations
    affecting the gene represented in this entry
  • Encephalopathy, neonatal severe, due to MECP2 mutations (ENS-MECP2) [MIM:300673]: A neurodevelopmental
    disorder characterized by severe neonatal encephalopathy, developmental delay, mental retardation, microcephaly,
    seizures. Additional features include respiratory insufficiency and central hypoventilation, gastroesophageal
    reflux, axial hypotonia, hyperreflexia and dyskinetic movements. Note=The disease is caused by mutations
    affecting the gene represented in this entry. The MECP2 gene is mutated in Rett syndrome, a severe
    neurodevelopmental disorder that almost always occurs in females. Although it was first thought that MECP2
    mutations causing Rett syndrome were lethal in males, later reports identified a severe neonatal encephalopathy
    in surviving male sibs of patients with Rett syndrome. Additional reports have confirmed a severe phenotype in
    males with Rett syndrome-associated MECP2 mutations
  • Mental retardation, X-linked, syndromic, Lubs type (MRXSL) [MIM:300260]: A disorder characterized by
    significantly below average general intellectual functioning associated with impairments in adaptive behavior and
    manifested during the developmental period. MRXSL patients manifest mental retardation associated with variable
    features. They include swallowing dysfunction and gastroesophageal reflux with secondary recurrent respiratory
    infections, hypotonia, mild myopathy and characteristic facies such as downslanting palpebral fissures,
    hypertelorism and a short nose with a low nasal bridge. Note=The disease is caused by mutations affecting the
    gene represented in this entry. Increased dosage of MECP2 due to gene duplication appears to be responsible for
    the mental retardation phenotype

  • Selected diseases for MECP2 (see all 29):    
    About MalaCards
    autism susceptibility, x-linked 3    bruxism    mecp2-related angelman-like syndrome    atypical rett syndrome
    rett syndrome    mental retardation, x-linked syndromic, lubs type    mecp2-related disorders    classic rett syndrome
    mecp2 duplication syndrome    lubs x-linked mental retardation syndrome    encephalopathy, neonatal severe    ppm-x syndrome
    infantile hypotonia    pervasive developmental disorder    rett syndrome, preserved speech variant    asperger syndrome
    angelman syndrome    alpha-thalassemia/mental retardation syndrome    gait apraxia    epileptic encephalopathy, early infantile, 2

    6 diseases from the University of Copenhagen DISEASES database for MECP2:
    Rett syndrome     Intellectual disability     Autistic disorder     Angelman syndrome
    Microcephaly     Gait apraxia

    Find genes that share disorders with MECP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MECP2 gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rett syndrome 99 776 19652677 (8), 14649549 (5), 18174559 (5), 17986102 (5) (see all 99)
    mental retardation 83.3 147 17084570 (4), 19806472 (4), 15814190 (4), 20163734 (4) (see all 78)
    encephalopathy neonatal 79.9 17 12719401 (2), 11930274 (2), 19559301 (2), 12447790 (1) (see all 13)
    angelman syndrome 79 19 15866439 (2), 15578581 (2), 11283202 (1), 14734626 (1) (see all 16)
    autistic 77 41 12770674 (4), 17427193 (3), 11464249 (3), 12707946 (3) (see all 23)
    severe mental retardation 72.3 13 18985075 (2), 12447790 (1), 16080119 (1), 11262731 (1) (see all 10)
    microcephaly 69 10 15939091 (1), 17936729 (1), 20142466 (1), 19090026 (1) (see all 8)
    pervasive developmental disorder 66 8 12027529 (1), 14734626 (1), 19189931 (1), 12555243 (1) (see all 5)
    neurological disorders 61.4 28 11242118 (1), 12928486 (1), 14529314 (1), 16354910 (1) (see all 20)
    infantile spasms 60.4 2 16806828 (1), 20397747 (1)

    GeneTests: MECP2
    GeneReviews: MECP2
    Genetic Association Database (GAD): MECP2
    Human Genome Epidemiology (HuGE) Navigator: MECP2 (78 documents)

    Export disorders for MECP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MECP2 gene, integrated from 10 sources (see all 698) (see top 10):
    (articles sorted by number of sources associating them with MECP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. (PubMed id 10508514)1, 2, 3, 9 Amir R.E....Zoghbi H.Y. (Nat. Genet. 1999)
    2. Low frequency of MECP2 mutations in mentally retarded males. (PubMed id 12111644)1, 2, 4 Yntema H.G....van Bokhoven H. (Eur. J. Hum. Genet. 2002)
    3. Diagnostic testing for Rett syndrome by DHPLC and direct sequencing analysis of the MECP2 gene: identification of several novel mutations and polymorphisms. (PubMed id 11055898)1, 2, 4 Buyse I.M.... Roa B.B. (Am. J. Hum. Genet. 2000)
    4. Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. (PubMed id 19333917)1, 4, 9 Webb R....Sawalha A.H. (Arthritis Rheum. 2009)
    5. Spectrum of MECP2 mutations in New Zealand Rett syndrome patients. (PubMed id 19652677)1, 4, 9 Raizis A.M....George P.M. (N. Z. Med. J. 2009)
    6. Drug-resistant epilepsy and epileptic phenotype-EEG association in MECP2 mutated Rett syndrome. (PubMed id 18842453)1, 4, 9 Buoni S....Hayek J. (Clin Neurophysiol 2008)
    7. [Methyl-CpG-binding protein 2 gene and CDKL5 gene mutation in patients with Rett syndrome: analysis of 177 Chinese pediatric patients]. (PubMed id 19552836)1, 4, 9 Li M.R....Wu X.R. (Zhonghua Yi Xue Za Zhi 2009)
    8. Structural variation in Xq28: MECP2 duplications in 1% of patients with unexplained XLMR and in 2% of male patients with severe encephalopathy. (PubMed id 18985075)1, 4, 9 Lugtenberg D....de Brouwer A.P. (Eur. J. Hum. Genet. 2009)
    9. MECP2 mutation analysis in patients with mental retardation. (PubMed id 15578581)1, 4, 9 Ylisaukko-Oja T....JAorvelAo I. (Am. J. Med. Genet. A 2005)
    10. The A140V mutation in the MECP2 gene is not a common etiological factor among Brazilian mentally retarded males. (PubMed id 15814190)1, 4, 9 dos Santos J.M....Pimentel M.M. (Neurosci. Lett. 2005)
    11. MECP2 mutations or polymorphisms in mentally retarded boys: diagnostic implications. (PubMed id 14529314)1, 4, 9 Bourdon V....Jonveaux P. (Mol. Diagn. 2003)
    12. Rett syndrome in a 47,XXX patient with a de novo MECP2 mutation. (PubMed id 12966522)1, 2, 9 Hammer S.... Schanen N.C. (Am. J. Med. Genet. A 2003)
    13. MECP2 is highly mutated in X-linked mental retardation. (PubMed id 11309367)1, 2, 9 Couvert P.... Cherif B. (Hum. Mol. Genet. 2001)
    14. High frequency of nonrecurrent MECP2 duplications among Brazilian males with mental retardation. (PubMed id 19806472)1, 4, 9 Campos M....Pimentel M.M. (J. Mol. Neurosci. 2010)
    15. MECP2 coding sequence and 3'UTR variation in 172 unrelated autistic patients. (PubMed id 17427193)1, 4, 9 Coutinho A.M....Vicente A.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    16. MECP2 and CDKL5 gene mutation analysis in Chinese patients with Rett syndrome. (PubMed id 17089071)1, 4, 9 Li M.R....Wu X.R. (J. Hum. Genet. 2007)
    17. Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. (PubMed id 16080119)1, 2, 9 Van Esch H.... Froyen G. (Am. J. Hum. Genet. 2005)
    18. The major form of MeCP2 has a novel N-terminus generated by alternative splicing. (PubMed id 15034150)1, 2, 9 Kriaucionis S. and Bird A. (Nucleic Acids Res. 2004)
    19. Mutations and polymorphisms in the human methyl CpG-binding protein MECP2. (PubMed id 12872250)1, 2, 9 Miltenberger-Miltenyi G. and Laccone F. (Hum. Mutat. 2003)
    20. MeCP2 mutations in children with and without the phenotype of Rett syndrome. (PubMed id 11402105)1, 2, 9 Hoffbuhr K.... Naidu S. (Neurology 2001)
    21. [Analysis of the parental origin of MECP2 mutations in patients with Rett syndrome]. (PubMed id 20376788)1, 4, 9 Zhang J.J....Wu X.R. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2010)
    22. MECP2 mutations in Malaysian Rett syndrome patients. (PubMed id 19495527)1, 4, 9 Fong C.B....Ariffin R. (Singapore Med J 2009)
    23. The p.Val66Met polymorphism in the BDNF gene protects against early seizures in Rett syndrome. (PubMed id 18434641)1, 4, 9 Nectoux J....Bienvenu T. (Neurology 2008)
    24. Methyl-CpG-binding protein 2 polymorphisms and vulnerability to autism. (PubMed id 19125863)1, 4, 9 Loat C.S....Craig I.W. (Genes Brain Behav. 2008)
    25. MeCP2 gene mutation analysis in autistic boys with developmental regression. (PubMed id 17413451)1, 4, 9 Xi C.Y....Ji Y.H. (Psychiatr. Genet. 2007)
    26. Stereotypies in Rett syndrome: analysis of 83 patients with and without detected MECP2 mutations. (PubMed id 17420401)1, 4, 9 Temudo T....Maciel P. (Neurology 2007)
    27. Low significance of MECP2 mutations as a cause of mental retardation in Brazilian males. (PubMed id 17084570)1, 4, 9 Campos M....Pimentel M.M. (amp 2007)
    28. Variation in exon 1 coding region and promoter of MECP2 in Rett syndrome and controls. (PubMed id 15367913)1, 4, 9 Evans J.C....Butler R. (Eur. J. Hum. Genet. 2005)
    29. CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome. (PubMed id 15917271)1, 2, 9 Mari F.... Landsberger N. (Hum. Mol. Genet. 2005)
    30. Identification of MeCP2 mutations in a series of females with autistic disorder. (PubMed id 12770674)1, 2, 9 Carney R.M.... Pericak-Vance M.A. (Pediatr. Neurol. 2003)
    31. Absence of MeCP2 mutations in patients from the South Carolina autism project. (PubMed id 12555243)1, 4, 9 Lobo-Menendez F....Michaelis R.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    32. Mutational analysis of the MECP2 gene in Japanese patients with Rett syndrome. (PubMed id 10944854)1, 2, 9 Amano K.... Yamakawa K. (J. Hum. Genet. 2000)
    33. Gross rearrangements of the MECP2 gene are found in both classical and atypical Rett syndrome patients. (PubMed id 16183801)1, 4, 9 Archer H.L....Clarke A.J. (J. Med. Genet. 2006)
    34. [Clinical symptoms of the Rett syndrome patients with MECP2 gene abnormalities]. (PubMed id 15675358)1, 4, 9 Miura K....Wakamatsu N. (No To Hattatsu 2005)
    35. Spectrum and distribution of MECP2 mutations in 64 Italian Rett syndrome girls: tentative genotype/phenotype correlation. (PubMed id 11738883)1, 2, 9 Giunti L.... Giovannucci Uzielli M.L. (Brain Dev. 2001)
    36. Linking MECP2 and pain sensitivity: the example of Rett syndrome. (PubMed id 20425824)1, 4, 9 Downs J....Leonard H. (Am. J. Med. Genet. A 2010)
    37. Analysis of highly conserved regions of the 3'UTR of MECP2 gene in patients with clinical diagnosis of Rett syndrome and other disorders associated with mental retardation. (PubMed id 18688080)1, 4, 9 Santos M....Maciel P. (Dis. Markers 2008)
    38. Mutation analysis of the MECP2 gene in patients of Slavic origin with Rett syndrome: novel mutations and polymorphisms. (PubMed id 17387578)1, 4, 9 Zahorakova D....Martasek P. (J. Hum. Genet. 2007)
    39. Diagnostic mutational analysis of MECP2 in Korean patients with Rett syndrome. (PubMed id 16672765)1, 4, 9 Kim I.J....Kim C.M. (amp 2006)
    40. A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome. (PubMed id 15034579)1, 2, 9 Mnatzakanian G.N.... Minassian B.A. (Nat. Genet. 2004)
    41. Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome. (PubMed id 15057977)1, 2, 9 Schanen C.... Percy A. (Am. J. Med. Genet. A 2004)
    42. MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism. (PubMed id 15211631)1, 4, 9 Shibayama A....Sommer S.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    43. A Rett syndrome MECP2 mutation that causes mental retardation in men. (PubMed id 11805248)1, 2, 9 Dotti M.T.... Federico A. (Neurology 2002)
    44. A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome. (PubMed id 11885030)1, 2, 9 Klauck S.M.... Poustka A. (Am. J. Hum. Genet. 2002)
    45. Mutation analysis of the MECP2 gene in British and Italian Rett syndrome females. (PubMed id 11269512)1, 2, 9 Vacca M.... Hulten M. (J. Mol. Med. 2001)
    46. Mutational analysis of MECP2 in Japanese patients with atypical Rett syndrome. (PubMed id 11376998)1, 2, 9 Inui K.... Okada S. (Brain Dev. 2001)
    47. Variation in novel exons (RACEfrags) of the MECP2 gene in Rett syndrome patients and controls. (PubMed id 19562714)1, 4, 9 Makrythanasis P....Antonarakis S.E. (Hum. Mutat. 2009)
    48. Methyl-CpG-binding protein 2 (MECP2) gene mutations in an Italian sample of patients with pervasive developmental disorder and mental retardation. (PubMed id 19189931)1, 4, 9 Parmeggiani A....Sangiorgi S. (J. Child Neurol. 2009)
    49. Novel exon 1 mutations in MECP2 implicate isoform MeCP2_e1 in classical Rett syndrome. (PubMed id 19365833)1, 4, 9 Saunders C.J....Vincent J.B. (Am. J. Med. Genet. A 2009)
    50. Rett syndrome: prevalence among Chinese and a comparison of MECP2 mutations of classic Rett syndrome with other neurodevelopmental disorders. (PubMed id 18174559)1, 4, 9 Wong V.C. and Li S.Y. (J. Child Neurol. 2007)
    51. Mutation screening of the MECP2 gene in a large cohort of 613 fragile-X negative patients with mental retardation. (PubMed id 17383248)1, 4, 9 Lesca G....Calender A. (Eur J Med Genet 2007)
    52. Sequence variants within exon 1 of MECP2 occur in females with mental retardation. (PubMed id 17171659)1, 4, 9 Harvey C.G....Vincent J.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    53. Screening for MECP2 mutations in Spanish patients with an unexplained mental retardation. (PubMed id 16879196)1, 4, 9 Tejada M.I....MilA! M. (Clin. Genet. 2006)
    54. MECP2 analysis in mentally retarded patients: implications for routine DNA diagnostics. (PubMed id 14560307)1, 4, 9 Kleefstra T....Hamel B.C. (Eur. J. Hum. Genet. 2004)
    55. Identification of a family with nonspecific mental retardation (MRX79) with the A140V mutation in the MECP2 gene: is there a need for routine screening? (PubMed id 12325019)1, 2, 9 Winnepenninckx B....Kooy R.F. (Hum. Mutat. 2002)
    56. Polymorphisms in the C-terminal domain of MECP2 in mentally handicapped boys: implications for genetic counselling. (PubMed id 11896461)1, 2, 9 Moncla A.... Villard L. (Eur. J. Hum. Genet. 2002)
    57. Spectrum of MECP2 mutations in Rett syndrome. (PubMed id 12180070)1, 4, 9 Bienvenu T....Chelly J. (Genet. Test. 2002)
    58. Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. (PubMed id 12384770)1, 2, 9 Beyer K.S....Poustka A. (Hum. Genet. 2002)
    59. Mutation spectrum in patients with Rett syndrome in the German population: evidence of hot spot regions. (PubMed id 11241840)1, 2, 9 Laccone F.... Meins M. (Hum. Mutat. 2001)
    60. MECP2 mutation in non-fatal, non-progressive encephalopathy in a male. (PubMed id 11238684)1, 2, 9 Imessaoudene B.... Amiel J. (J. Med. Genet. 2001)
    61. Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein. (PubMed id 11283202)1, 2, 9 Watson P....Clayton-Smith J. (J. Med. Genet. 2001)
    62. MECP2 mutation in male patients with non-specific X-linked mental retardation. (PubMed id 11007980)1, 2, 9 Orrico A.... Sorrentino V. (FEBS Lett. 2000)
    63. A mutation in the Rett syndrome gene, MECP2, causes X-linked mental retardation and progressive spasticity in males. (PubMed id 10986043)1, 2, 9 Meloni I.... Renieri A. (Am. J. Hum. Genet. 2000)
    64. Mutation screening in Rett syndrome patients. (PubMed id 10745042)1, 2, 9 Xiang F.... Anvret M. (J. Med. Genet. 2000)
    65. Methyl-CpG-binding protein MeCP2 represses Sp1-activated transcription of the human leukosialin gene when the promoter is methylated. (PubMed id 9710633)1, 2, 9 Kudo S. (Mol. Cell. Biol. 1998)
    66. Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2. (PubMed id 8672133)1, 2, 9 D'Esposito M.... Brown S.D.M. (Mamm. Genome 1996)
    67. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. (PubMed id 20881011)1, 4 Webb R....Sawalha A.H. (Ann. Rheum. Dis. 2011)
    68. Bone mass in Rett syndrome: association with clinical parameters and MECP2 mutations. (PubMed id 20661168)1, 4 Shapiro J.R....Naidu S. (Pediatr. Res. 2010)
    69. Epilepsy in Rett syndrome---the experience of a National Rett Center. (PubMed id 20491871)1, 4 Nissenkorn A....Ben Zeev B. (Epilepsia 2010)
    70. Profiling scoliosis in Rett syndrome. (PubMed id 20032810)1, 4 Percy A.K....Glaze D.G. (Pediatr. Res. 2010)
    71. Epilepsy in Rett syndrome: clinical and genetic features. (PubMed id 20728410)1, 4 Pintaudi M....Veneselli E. (amp 2010)
    72. Identification and characterization of novel sequence variations in MECP2 gene in Rett syndrome patients. (PubMed id 20031356)1, 4 Monnerat L.S....Vargas F.R. (amp 2010)
    73. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    74. Level of purposeful hand function as a marker of clinical severity in Rett syndrome. (PubMed id 20345957)1, 4 Downs J....Leonard H. (Dev Med Child Neurol 2010)
    75. Rett syndrome and long-term disorder profile. (PubMed id 19133691)1, 4 Smeets E.E....Frijns J.P. (Am. J. Med. Genet. A 2009)
    76. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    77. Brain metabolism in Rett syndrome: age, clinical, and genotype correlations. (PubMed id 19194883)1, 4 HorskA! A....Naidu S. (Ann. Neurol. 2009)
    78. A multiplexed ARMS-PCR approach for the detection of common MECP2 mutations. (PubMed id 19309269)1, 4 Baris I. and Battaloglu E. (Genet Test Mol Biomarkers 2009)
    79. Genotype-phenotype correlation in Brazillian Rett syndrome patients. (PubMed id 19722030)1, 4 Lima F.T....Pereira L.d.a. .V. (Arq Neuropsiquiatr 2009)
    80. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations. (PubMed id 19717458)1, 4 Joyner A.H....Dale A.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    81. [Correlation between MECP2 genotype and phenotype in Chinese patients with Rett syndrome]. (PubMed id 19573459)1, 4 Li M.R....Wu X.R. (Zhonghua Er Ke Za Zhi 2009)
    82. Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)1, 4 Guilmatre A....Campion D. (Arch. Gen. Psychiatry 2009)
    83. Movement disorders in Rett syndrome: an analysis of 60 patients with detected MECP2 mutation and correlation with mutation type. (PubMed id 18512755)1, 4 Temudo T....Maciel P. (Mov. Disord. 2008)
    84. Early determinants of fractures in Rett syndrome. (PubMed id 18310203)1, 4 Downs J....Leonard H. (Pediatrics 2008)
    85. Common variants within MECP2 confer risk of systemic lupus erythematosus. (PubMed id 18320046)1, 4 Sawalha A.H....Harley J.B. (PLoS ONE 2008)
    86. Bone mineral content and bone mineral density are lower in older than in younger females with Rett syndrome. (PubMed id 18535484)1, 4 Motil K.J....Glaze D.G. (Pediatr. Res. 2008)
    87. Gross motor profile in rett syndrome as determined by video analysis. (PubMed id 19165708)1, 4 Downs J.A....Leonard H. (Neuropediatrics 2008)
    88. X chromosome inactivation in Rett Syndrome and its correlations with MECP2 mutations and phenotype. (PubMed id 18184939)1, 4 Xinhua Bao ....Wu X.R. (J. Child Neurol. 2008)
    89. Investigating genotype-phenotype relationships in Rett syndrome using an international data set. (PubMed id 18332345)1, 4 Bebbington A....Leonard H. (Neurology 2008)
    90. A novel familial MECP2 mutation in a young boy: clinical and molecular findings. (PubMed id 16966553)1, 2 Ventura P.... Massagli A. (Neurology 2006)
    91. p.R270X MECP2 mutation and mortality in Rett syndrome. (PubMed id 16077729)1, 4 Jian L....Leonard H. (Eur. J. Hum. Genet. 2005)
    92. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    93. Dimensional phenotypic analysis and functional categorisation of mutations reveal novel genotype-phenotype associations in Rett syndrome. (PubMed id 16077736)1, 4 Charman T....Bailey M.E. (Eur. J. Hum. Genet. 2005)
    94. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    95. Mutation analysis of the MECP2 gene in patients with Rett syndrome. (PubMed id 12567420)1, 2 Conforti F.L.... Mangone L. (Am. J. Med. Genet. A 2003)
    96. Neurodevelopmental disorders in males related to the gene causing Rett syndrome in females (MECP2). (PubMed id 12615169)1, 2 Moog U.... Schrander-Stumpel C.T.R.M. (Eur. J. Paediatr. Neurol. 2003)
    97. Rett syndrome in adolescent and adult females: clinical and molecular genetic findings. (PubMed id 12966523)1, 2 Smeets E.... Fryns J.-P. (Am. J. Med. Genet. A 2003)
    98. Indication for genetic testing: a checklist for Rett syndrome. (PubMed id 12640384)1, 4 Huppke P....Hanefeld F. (J. Pediatr. 2003)
    99. Influence of mutation type and location on phenotype in 123 patients with Rett syndrome. (PubMed id 12075485)1, 4 Huppke P....Laccone F. (Neuropediatrics 2002)
    100. [Mutation spectrum and genotype-phenotype correlation of MECP2 in patients with Rett syndrome]. (PubMed id 12030010)1, 4 Kondo I. and Yamagata H. (No To Hattatsu 2002)
    101. MECP2 gene nucleotide changes and their pathogenicity in males: proceed with caution. (PubMed id 12161600)1, 2 Laccone F.... Trappe R. (J. Med. Genet. 2002)
    102. Classic Rett syndrome in a boy as a result of somatic mosaicism for a MECP2 mutation. (PubMed id 11706982)1, 2 Armstrong J....Monros E. (Ann. Neurol. 2001)
    103. Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. (PubMed id 10723722)1, 2 Reichwald K.... Kioschis P. (Mamm. Genome 2000)
    104. Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location. (PubMed id 10767337)1, 2 Cheadle J.P.... Clarke A. (Hum. Mol. Genet. 2000)
    105. MECP2 mutations account for most cases of typical forms of Rett syndrome. (PubMed id 10814719)1, 2 Bienvenu T.... Chelly J. (Hum. Mol. Genet. 2000)
    106. Mutations in the MECP2 gene in a cohort of girls with Rett syndrome. (PubMed id 10991689)1, 2 Hampson K.... Webb T. (J. Med. Genet. 2000)
    107. Mutation analysis of the methyl-CpG binding protein 2 gene (MECP2) in patients with Rett syndrome. (PubMed id 10991688)1, 2 Obata K.... Kondo I. (J. Med. Genet. 2000)
    108. Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots. (PubMed id 10577905)1, 2 Wan M.... Francke U. (Am. J. Hum. Genet. 1999)
    109. The solution structure of the domain from MeCP2 that binds to methylated DNA. (PubMed id 10518942)1, 2 Wakefield R.I.... Barlow P.N. (J. Mol. Biol. 1999)
    110. A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3'-untranslated region of the methyl- CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression. (PubMed id 10369871)1, 2 Coy J.F.... Poustka A. (Hum. Mol. Genet. 1999)
    111. Assignment of the gene for methyl-CpG-binding protein 2 (MECP2) to human chromosome band Xq28 by in situ hybridization. (PubMed id 8976388)1, 2 Vilain A.... Malfoy B. (Cytogenet. Cell Genet. 1996)
    112. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. (PubMed id 1606614)1, 3 Lewis J.D....Bird A. (Cell 1992)
    113. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. (PubMed id 17486179)1, 9 Nagarajan R.P....LaSalle J.M. (Epigenetics 2006)
    114. Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism. (PubMed id 19000991)1, 9 Swanberg S.E....LaSalle J.M. (Hum. Mol. Genet. 2009)
    115. Survey of MeCP2 in the Rett syndrome and the non-Rett syndrome brain. (PubMed id 14649549)1, 9 Armstrong D.D....Antallfy B. (J. Child Neurol. 2003)
    116. Genetic modifiers of MeCP2 function in Drosophila. (PubMed id 18773074)1, 9 Cukier H.N....Botas J. (PLoS Genet. 2008)
    117. Identification of cis-regulatory elements for MECP2 expression. (PubMed id 16613900)1, 9 Liu J. and Francke U. (Hum. Mol. Genet. 2006)
    118. Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. (PubMed id 16682435)1, 9 Peddada S....LaSalle J.M. (Hum. Mol. Genet. 2006)
    119. A novel protein, Xenopus p20, influences the stability of MeCP2 through direct interaction. (PubMed id 15056664)1, 9 Carro S....Landsberger N. (J. Biol. Chem. 2004)
    120. Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylation. (PubMed id 12545250)1, 9 Balmer D....LaSalle J.M. (J. Mol. Med. 2003)
    121. The role of MeCP2 in brain development and neurodevelopmental disorders. (PubMed id 20425298)1, 9 Gonzales M.L. and LaSalle J.M. (Curr Psychiatry Rep 2010)
    122. Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome. (PubMed id 20035514)1, 9 Ramocki M.B....Zoghbi H.Y. (Ann. Neurol. 2009)
    123. DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. (PubMed id 17701895)1, 9 SchA1le B....Francke U. (Am. J. Hum. Genet. 2007)
    124. MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production. (PubMed id 18075316)1, 9 Abuhatzira L....Shemer R. (Epigenetics 2007)
    125. Methyl-CpG-binding protein 2 is localized in the postsynaptic compartment: an immunochemical study of subcellular fractions. (PubMed id 12535940)1, 9 Aber K.M....Kaufmann W.E. (Neuroscience 2003)
    126. MeCP2 expression in human cerebral cortex and lymphoid cells: immunochemical characterization of a novel higher-molecular-weight form. (PubMed id 14649548)1, 9 Jarrar M.H....Kaufmann W.E. (J. Child Neurol. 2003)
    127. Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. (PubMed id 11809720)1, 9 Shahbazian M.D....Zoghbi H.Y. (Hum. Mol. Genet. 2002)
    128. The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domains. (PubMed id 20032179)1, 9 Matsumura S....Wilson A.C. (J. Virol. 2010)
    129. MeCP2 involvement in the regulation of neuronal alpha-tubulin production. (PubMed id 19174478)1, 9 Abuhatzira L....Razin A. (Hum. Mol. Genet. 2009)
    130. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. (PubMed id 19386901)1, 9 Maezawa I....Jin L.W. (J. Neurosci. 2009)
    131. Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males. (PubMed id 17172942)1, 9 del Gaudio D....Roa B.B. (Genet. Med. 2006)
    132. Spectrum and distribution of MECP2 mutations in 424 Rett syndrome patients: a molecular update. (PubMed id 16473305)1, 9 Philippe C....Bienvenu T. (Eur J Med Genet 2006)
    133. Large genomic rearrangements in MECP2. (PubMed id 15712379)1, 9 Ravn K....Schwartz M. (Hum. Mutat. 2005)
    134. Heterogeneity in residual function of MeCP2 carrying missense mutations in the methyl CpG binding domain. (PubMed id 12843318)4, 9 Kudo S....Tamura M. (J. Med. Genet. 2003)
    135. Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA. (PubMed id 20065105)1, 9 Squillaro T....Galderisi U. (FASEB J. 2010)
    136. Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations. (PubMed id 19442733)1, 9 Chapleau C.A....Pozzo-Miller L. (Neurobiol. Dis. 2009)
    137. MECP2 mutations in Serbian Rett syndrome patients. (PubMed id 17986102)1, 9 Djarmati A....Romac S. (Acta Neurol. Scand. 2007)
    138. Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. (PubMed id 15351775)1, 9 Collins A.L....Zoghbi H.Y. (Hum. Mol. Genet. 2004)
    139. MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status. (PubMed id 14612906)1, 9 MA1ller H.M....Widschwendter M. (Br. J. Cancer 2003)
    140. Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription. (PubMed id 11691937)1, 9 Yu F....StrAotling W.H. (Nucleic Acids Res. 2001)
    141. Semi-dominant X-chromosome linked learning disability with progressive ataxia, spasticity and dystonia associated with the novel MECP2 variant p.V122A: akin to the new MECP2 duplication syndrome? (PubMed id 19592282)1, 9 McWilliam C....Tolmie J.L. (Eur. J. Paediatr. Neurol. 2010)
    142. [Research progress of Rett syndrome causing gene MECP2--the structure, function and modulation of MECP2]. (PubMed id 20019788)1, 9 Zhang J.J. and Bao X.H. (Beijing Da Xue Xue Bao 2009)
    143. Skewed X chromosome inactivation failed to explain the normal phenotype of a carrier female with MECP2 mutation resulting in Rett syndrome. (PubMed id 18190595)1, 9 Takahashi S....Fujieda K. (Clin. Genet. 2008)
    144. MECP2 mutations in males. (PubMed id 17351020)1, 9 Villard L. (J. Med. Genet. 2007)
    145. [MECP2 gene mutations in twenty-six cases with atypical Rett syndrome]. (PubMed id 16780651)1, 9 Li M.R....Wu X.R. (Zhonghua Er Ke Za Zhi 2006)
    146. Recurrent infections, hypotonia, and mental retardation caused by duplication of MECP2 and adjacent region in Xq28. (PubMed id 17088400)1, 9 Friez M.J....Stevenson R.E. (Pediatrics 2006)
    147. MeCP2 expression and function during brain development: implications for Rett syndrome's pathogenesis and clinical evolution. (PubMed id 16182491)1, 9 Kaufmann W.E....Blue M.E. (amp 2005)
    148. MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression. (PubMed id 15757975)1, 9 Makedonski K....Shemer R. (Hum. Mol. Genet. 2005)
    149. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. (PubMed id 12427740)1, 9 Fuks F....Kouzarides T. (J. Biol. Chem. 2003)
    150. Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. (PubMed id 12473678)1, 9 Kimura H. and Shiota K. (J. Biol. Chem. 2003)
    151. Somatic mosaicism for a MECP2 mutation associated with classic Rett syndrome in a boy. (PubMed id 11896459)1, 9 TopAsu M....OzAselik T. (Eur. J. Hum. Genet. 2002)
    152. Severe congenital encephalopathy caused by MECP2 null mutations in males: central hypoxia and reduced neuronal dendritic structure. (PubMed id 18477000)1, 9 SchA1le B....Francke U. (Clin. Genet. 2008)
    153. Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome. (PubMed id 18337588)1, 9 Neul J.L....Glaze D.G. (Neurology 2008)
    154. Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes. (PubMed id 18666890)1, 9 Yaqinuddin A....Qureshi S.A. (Biosci. Rep. 2008)
    155. MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. (PubMed id 17698499)1, 9 Agarwal N....Cardoso M.C. (Nucleic Acids Res. 2007)
    156. Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. (PubMed id 17296936)1, 9 Nan X....Bird A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    157. Rett syndrome: North American database. (PubMed id 18174548)1, 9 Percy A.K....MacLeod P. (J. Child Neurol. 2007)
    158. The incidence of Rett syndrome in France. (PubMed id 16647997)1, 9 Bienvenu T....Villard L. (Pediatr. Neurol. 2006)
    159. Study of MECP2 gene in Rett syndrome variants and autistic girls. (PubMed id 12707946)1, 9 Zappella M....Renieri A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    160. Segregation of a totally skewed pattern of X chromosome inactivation in four familial cases of Rett syndrome without MECP2 mutation: implications for the disease. (PubMed id 11432961)1, 9 Villard L....FontA"s M. (J. Med. Genet. 2001)
    161. A novel MECP2 mutation in a boy with neonatal encephalopathy and facial dysmorphism. (PubMed id 19559301)1, 9 JA1lich K....Auber B. (J. Pediatr. 2009)
    162. 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. (PubMed id 17339270)1, 9 Hogart A....Lasalle J.M. (Hum. Mol. Genet. 2007)
    163. Early progressive encephalopathy in boys and MECP2 mutations. (PubMed id 16832102)1, 9 Kankirawatana P....Percy A.K. (Neurology 2006)
    164. Large deletions of the MECP2 gene detected by gene dosage analysis in patients with Rett syndrome. (PubMed id 14974082)1, 9 Laccone F....Ravine D. (Hum. Mutat. 2004)
    165. Investigation of UBE3A and MECP2 in Angelman syndrome (AS) and patients with features of AS. (PubMed id 14981718)1, 9 Hitchins M.P....Malcolm S. (Am. J. Med. Genet. A 2004)
    166. Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer. (PubMed id 15526354)1, 9 Fang J.Y....Lu L.G. (World J. Gastroenterol. 2004)
    167. MECP2 mutation in a boy with severe neonatal encephalopathy: clinical, neuropathological and molecular findings. (PubMed id 11930274)1, 9 Geerdink N....Hamel B.C. (Neuropediatrics 2002)
    168. Magnetic resonance spectroscopy and analysis of MECP2 in Rett syndrome. (PubMed id 11955928)1, 9 Khong P.L....Wong V.C. (Pediatr. Neurol. 2002)
    169. [Mutational analysis of MECP2 gene in Rett syndrome]. (PubMed id 12170461)1, 9 Pan H....Wu X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002)
    170. Familial interstitial Xq27.3q28 duplication encompassing the FMR1 gene but not the MECP2 gene causes a new syndromic mental retardation condition. (PubMed id 19844254)1, 9 Rio M....Colleaux L. (Eur. J. Hum. Genet. 2010)
    171. The MECP2 duplication syndrome. (PubMed id 20425814)1, 9 Ramocki M.B....Peters S.U. (Am. J. Med. Genet. A 2010)
    172. Unique physical properties and interactions of the domains of methylated DNA binding protein 2. (PubMed id 20405910)1, 9 Ghosh R.P....Woodcock C.L. (Biochemistry 2010)
    173. Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain. (PubMed id 20420693)1, 9 Gibson J.H....Christodoulou J. (BMC Neurosci 2010)
    174. Phenotypic and genotypic variability in four males with MECP2 gene sequence aberrations including a novel deletion. (PubMed id 20098342)1, 9 Psoni S....Fryssira-Kanioura H. (Pediatr. Res. 2010)
    175. Two brothers with a microduplication including the MECP2 gene: rapid head growth in infancy and resolution of susceptibility to infection. (PubMed id 19057379)1, 9 Prescott T.E....Stray-Pedersen A. (Clin. Dysmorphol. 2009)
    176. The clinical variability of the MECP2 duplication syndrome: description of two families with duplications excluding L1CAM and FLNA. (PubMed id 19018795)1, 9 Kirk E.P....Badens C. (Clin. Genet. 2009)
    177. A novel MECP2 gene mutation in a Tunisian patient with Rett syndrome. (PubMed id 19309283)1, 9 Fendri-Kriaa N....Fakhfakh F. (Genet Test Mol Biomarkers 2009)
    178. Complex rearrangements in patients with duplications of MECP2 can occur by fork stalling and template switching. (PubMed id 19324899)1, 9 Carvalho C.M....Lupski J.R. (Hum. Mol. Genet. 2009)
    179. A novel hypomorphic MECP2 point mutation is associated with a neuropsychiatric phenotype. (PubMed id 18989701)1, 9 Adegbola A.A....Cox G.F. (Hum. Genet. 2009)
    180. The Odyssey of MeCP2 and parental imprinting. (PubMed id 17965611)1, 9 LaSalle J.M. (Epigenetics 2007)
    181. The odyssey of MeCP2 and parental imprinting. (PubMed id 17486180)1, 9 LaSalle J.M. (Epigenetics 2007)
    182. FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. (PubMed id 17309881)1, 9 Deng V....Ojeda S.R. (Hum. Mol. Genet. 2007)
    183. Spatio-temporal dynamics and localization of MeCP2 and pathological mutants in living cells. (PubMed id 17965612)1, 9 Marchi M....Costa M. (Epigenetics 2007)
    184. Male Rett phenotypes in T158M and R294X MeCP2-mutations. (PubMed id 17236109)1, 9 Lundvall M....Kyllerman M. (Neuropediatrics 2006)
    185. The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth. (PubMed id 16331274)1, 9 Bernard D....de Launoit Y. (Oncogene 2006)
    186. Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. (PubMed id 15696166)1, 9 Harikrishnan K.N....El-Osta A. (Nat. Genet. 2005)
    187. Submicroscopic duplication in Xq28 causes increased expression of the MECP2 gene in a boy with severe mental retardation and features of Rett syndrome. (PubMed id 15689435)1, 9 Meins M....Epplen J.T. (J. Med. Genet. 2005)
    188. Association by guilt: identification of DLX5 as a target for MeCP2 provides a molecular link between genomic imprinting and Rett syndrome. (PubMed id 15954098)1, 9 Bapat S. and Galande S. (Bioessays 2005)
    189. Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. (PubMed id 15689352)1, 9 Thatcher K.N....Lasalle J.M. (Hum. Mol. Genet. 2005)
    190. DNA binding of methyl-CpG-binding protein MeCP2 in human MCF7 cells. (PubMed id 15109260)1, 9 Koch C. and StrAotling W.H. (Biochemistry 2004)
    191. A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome. (PubMed id 14618241)1, 9 Buschdorf J.P. and StrAotling W.H. (J. Mol. Med. 2004)
    192. Early-onset encephalopathy and cortical myoclonus in a boy with MECP2 gene mutation. (PubMed id 15557528)1, 9 Leuzzi V....Seri S. (Neurology 2004)
    193. MECP2 gene mutations in non-syndromic X-linked mental retardation: phenotype-genotype correlation. (PubMed id 14598336)1, 9 Gomot M....Moraine C. (Am. J. Med. Genet. A 2003)
    194. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. (PubMed id 14593184)1, 9 Martinowich K....Sun Y.E. (Science 2003)
    195. Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2. (PubMed id 12646234)1, 9 Patra S.K....Dahiya R. (Biochem. Biophys. Res. Commun. 2003)
    196. Functional characterisation of MeCP2 mutations found in male patients with X linked mental retardation. (PubMed id 11836365)1, 9 Kudo S....Tamura M. (J. Med. Genet. 2002)
    197. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. (PubMed id 11748221)1, 9 Dintilhac A. and BernuAcs J. (J. Biol. Chem. 2002)
    198. Infantile hypotonia as a presentation of Rett syndrome. (PubMed id 12210319)1, 9 Heilstedt H.A....Lee B. (Am. J. Med. Genet. 2002)
    199. Rett syndrome: clinical manifestations in males with MECP2 mutations. (PubMed id 11913564)1, 9 Zeev B.B....Orr-Urtreger A. (J. Child Neurol. 2002)
    200. In-frame deletion in MECP2 causes mild nonspecific mental retardation. (PubMed id 11807877)1, 9 Yntema H.G....Moraine C. (Am. J. Med. Genet. 2002)
    201. Rett syndrome: analysis of MECP2 and clinical characterization of 31 patients. (PubMed id 10814718)1, 9 Huppke P....Hanefeld F. (Hum. Mol. Genet. 2000)
    202. MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery. (PubMed id 10756192)1, 9 Kaludov N.K. and Wolffe A.P. (Nucleic Acids Res. 2000)
    203. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. (PubMed id 9038338)1, 9 Nan X....Bird A. (Cell 1997)
    204. De novo MECP2 duplication derived from paternal germ line result in dysmorphism and developmental delay. (PubMed id 24129071)1 Lin D.S....Li L.H. (Gene 2014)
    205. Adolescent onset cognitive regression and neuropsychiatric symptoms associated with the A140V MECP2 mutation. (PubMed id 24328834)1 Venkateswaran S....Humphreys P. (Dev Med Child Neurol 2014)
    206. An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders. (PubMed id 23452848)1 Baker S.A....Zoghbi H.Y. (Cell 2013)
    207. Mechanisms and therapeutic challenges in autism spectrum disorders: insights from Rett syndrome. (PubMed id 23449173)1 Castro J....Sur M. (Curr. Opin. Neurol. 2013)
    208. MECP2 duplication syndrome in both genders. (PubMed id 22877836)1 Shimada S....Yamamoto T. (amp 2013)
    209. Relationship between Mecp2 and NFI_b signaling during neural differentiation of P19 cells. (PubMed id 23123205)1 O'Driscoll C....Bressler J. (Brain Res. 2013)
    210. New insight on the Xq28 association with systemic sclerosis. (PubMed id 23444193)1 Carmona F.D....MartA-n J. (Ann. Rheum. Dis. 2013)
    211. MeCP2 deficiency is associated with impaired microtubule stability. (PubMed id 23238081)1 DelAcpine C....Bienvenu T. (FEBS Lett. 2013)
    212. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. (PubMed id 22904263)1 Kaufman K.M....Tsao B.P. (Ann. Rheum. Dis. 2013)
    213. Detection of rarely identified multiple mutations in MECP2 gene do not contribute to enhanced severity in Rett syndrome. (PubMed id 23696494)1 Chapleau C.A....Percy A.K. (Am. J. Med. Genet. A 2013)
    214. Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats. (PubMed id 23624957)1 Xue J....Zempleni J. (Epigenetics 2013)
    215. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. (PubMed id 23428850)1 Koelsch K.A....Sawalha A.H. (J. Autoimmun. 2013)
    216. The behavioral phenotype in MECP2 duplication syndrome: a comparison with idiopathic autism. (PubMed id 23169761)1 Peters S.U....Ramocki M.B. (Autism Res 2013)
    217. Ube3a/E6AP is involved in a subset of MeCP2 functions. (PubMed id 23791832)1 Kim S....Lim J. (Biochem. Biophys. Res. Commun. 2013)
    218. Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. (PubMed id 23349465)1 Theisen J.W....Kadonaga J.T. (J. Biol. Chem. 2013)
    219. Spectrum of MECP2 gene mutations in a cohort of Indian patients with Rett syndrome: report of two novel mutations. (PubMed id 23262346)1 Das D.K....Udani V. (Gene 2013)
    220. The impact of MeCP2 loss- or gain-of-function on synaptic plasticity. (PubMed id 22781840)1 Na E.S....Monteggia L.M. (Neuropsychopharmacology 2013)
    221. Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family. (PubMed id 23135915)1 Ray B.K....Ray A. (Cancer Res. 2013)
    222. Common Variants on Xq28 Conferring Risk of Schizophrenia in Han Chinese. (PubMed id 24043878)1 Wong E.H....Sham P.C. (Schizophr Bull 2013)
    223. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    224. Mutational analysis of methyl-CpG binding protein 2 (MECP2) gene in Indian cases of Rett syndrome. (PubMed id 23400946)1 Das D.K....Maitra A. (J. Clin. Lab. Anal. 2013)
    225. [Subchromosomal microdeletion identified by molecular karyotyping using DNA microarrays (array CGH) in Rett syndrome girls negative for MECP2 gene mutations]. (PubMed id 24300809)1 Vorsanova S.G....Iurov I.u.B. (Zh Nevrol Psikhiatr Im S S Korsakova 2013)
    226. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    227. A synonymous change, p.Gly16Gly in MECP2 Exon 1, causes a cryptic splice event in a Rett syndrome patient. (PubMed id 23866855)1 Sheikh T.I....Vincent J.B. (Orphanet J Rare Dis 2013)
    228. Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p. (PubMed id 23431031)1 Han K....Zoghbi H.Y. (amp 2013)
    229. Association of MeCP2 (rs2075596, rs2239464) genetic polymorphisms with systemic lupus erythematosus: a meta-analysis. (PubMed id 23857988)1 Liu K....Hong Q. (Lupus 2013)
    230. Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. (PubMed id 23633923)1 Piazza R....Gambacorti-Passerini C. (Neoplasia 2013)
    231. Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression. (PubMed id 23493374)1 Chen Y....Devaskar S.U. (Endocrinology 2013)
    232. Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. (PubMed id 23770565)1 Lyst M.J....Bird A. (Nat. Neurosci. 2013)
    233. Association of an activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype with increased susceptibility to rheumatoid arthritis. (PubMed id 23233309)1 Han T.U....Kang C. (Arthritis Rheum. 2013)
    234. Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. (PubMed id 23446634)1 Chen Z....Reiner A.P. (Hum. Mol. Genet. 2013)
    235. The role of methyl-CpG binding protein 2 in liver fibrosis. (PubMed id 23619607)1 Bian E.B....Li J. (Toxicology 2013)
    236. Relationship between methyl CpG binding protein 2 and JC viral proteins. (PubMed id 23514909)1 Takahashi K....Tanaka S. (Jpn. J. Infect. Dis. 2013)
    237. A partial MECP2 duplication in a mildly affected adult male: a putative role for the 3' untranslated region in the MECP2 duplication phenotype. (PubMed id 22883432)1 Hanchard N.A....Cheung S.W. (BMC Med. Genet. 2012)
    238. MECP2 mutations and clinical correlations in Greek children with Rett syndrome and associated neurodevelopmental disorders. (PubMed id 21982064)1 Psoni S....Fryssira-Kanioura H. (amp 2012)
    239. The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1. (PubMed id 23055267)1 Cukier H.N....Gilbert J.R. (Autism Res 2012)
    240. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    241. Drosophila as a model for MECP2 gain of function in neurons. (PubMed id 22363746)1 Vonhoff F....Duch C. (PLoS ONE 2012)
    242. Molecular diagnostic dilemmas in Rett syndrome. (PubMed id 22277191)1 Zvereff V....Friedman K.J. (amp 2012)
    243. Novel double deletions in the MECP2 gene in Tunisian Rett patient. (PubMed id 22561697)1 Fendri-Kriaa N....Fakhfakh F. (Gene 2012)
    244. The phenotype associated with a large deletion on MECP2. (PubMed id 22473088)1 Bebbington A....Leonard H. (Eur. J. Hum. Genet. 2012)
    245. Novel mutations in the C-terminal region of the MECP2 gene in Tunisian Rett syndrome patients. (PubMed id 21940684)1 Fendri-Kriaa N....Fakhfakh F. (J. Child Neurol. 2012)
    246. Novel non-identical MECP2 mutations in Rett syndrome family: a rare presentation. (PubMed id 21300488)1 Khajuria R....Kabra M. (amp 2012)
    247. Subclinical myocardial dysfunction in Rett syndrome. (PubMed id 22113206)1 De Felice C....Hayek J. (Eur Heart J Cardiovasc Imaging 2012)
    248. A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections. (PubMed id 22909152)1 Xu X....Yu X. (BMC Med. Genet. 2012)
    249. Electroclinical pattern in MECP2 duplication syndrome: eight new reported cases and review of literature. (PubMed id 22578097)1 Vignoli A....Canevini M.P. (Epilepsia 2012)
    250. The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas. (PubMed id 22455563)1 Xu X....Quan C. (Diagn Pathol 2012)
    251. Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation. (PubMed id 22615490)1 Gonzales M.L....LaSalle J.M. (Mol. Cell. Biol. 2012)
    252. Apneic crises: a clue for MECP2 testing in severe neonatal hypotonia-respiratory failure. (PubMed id 22497713)1 Falsaperla R....Pavone P. (Eur. J. Paediatr. Neurol. 2012)
    253. Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells. (PubMed id 22783988)1 Babbio F....Bonapace I.M. (BMC Cell Biol. 2012)
    254. Genetic and epileptic features in Rett syndrome. (PubMed id 22476991)1 Kim H.J....Kang H.C. (Yonsei Med. J. 2012)
    255. Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome. (PubMed id 22357617)1 Squillaro T....Galderisi U. (Mol. Biol. Cell 2012)
    256. Algorithmic approach for methyl-CpG binding protein 2 (MECP2) gene testing in patients with neurodevelopmental disabilities. (PubMed id 22123427)1 Sanmann J.N....Sanger W.G. (J. Child Neurol. 2012)
    257. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    258. MECP2 triplication in 3 brothers - a rarely described cause of familial neurological regression in boys. (PubMed id 21821449)1 Tang S.S....Fallon P. (Eur. J. Paediatr. Neurol. 2012)
    259. Up-regulated methyl CpG binding protein-2 in intractable temporal lobe epilepsy patients and a rat model. (PubMed id 22707285)1 Tao S....Wang X. (Neurochem. Res. 2012)
    260. Mutations in MECP2 exon 1 in classical Rett patients disrupt MECP2_e1 transcription, but not transcription of MECP2_e2. (PubMed id 22213695)1 Gianakopoulos P.J....Vincent J.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
    261. Molecular screening of MECP2 gene in a cohort of Lebanese patients suspected with Rett syndrome: report on a mild case with a novel indel mutation. (PubMed id 21954873)1 Corbani S....Megarbane A. (J Intellect Disabil Res 2012)
    262. The relationship of Rett syndrome and MECP2 disorders to autism. (PubMed id 23226951)1 Neul J.L. (Dialogues Clin Neurosci 2012)
    263. The incidence of hypoplasia of the corpus callosum in patients with dup (X)(q28) involving MECP2 is associated with the location of distal breakpoints. (PubMed id 22528406)1 Honda S....Inazawa J. (Am. J. Med. Genet. A 2012)
    264. Early speech-language development in females with Rett syndrome: focusing on the preserved speech variant. (PubMed id 22348320)1 Marschik P.B....Einspieler C. (Dev Med Child Neurol 2012)
    265. Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. (PubMed id 22119903)1 Goffin D....Zhou Z. (Nat. Neurosci. 2012)
    266. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. (PubMed id 23260135)1 MellAcn M....Heintz N. (Cell 2012)
    267. Elevated IKKI+ accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression. (PubMed id 22848609)1 Khoshnan A. and Patterson P.H. (PLoS ONE 2012)
    268. The Rett syndrome protein MeCP2 regulates synaptic scaling. (PubMed id 22262897)1 Qiu Z....Ghosh A. (J. Neurosci. 2012)
    269. Gastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome. (PubMed id 22331013)1 Motil K.J....Glaze D.G. (J. Pediatr. Gastroenterol. Nutr. 2012)
    270. Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research. (PubMed id 22474603)1 Zachariah R.M. and Rastegar M. (Neural Plast. 2012)
    271. Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome. (PubMed id 22532851)1 Okabe Y....Matsuishi T. (PLoS ONE 2012)
    272. The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity. (PubMed id 22275515)1 Leoh L.S....Casiano C.A. (Mol. Cancer Res. 2012)
    273. A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission. (PubMed id 22378884)1 Na E.S....Monteggia L.M. (J. Neurosci. 2012)
    274. Cell-autonomous alterations in dendritic arbor morphology and connectivity induced by overexpression of MeCP2 in Xenopus central neurons in vivo. (PubMed id 22427975)1 Marshak S....Cohen-Cory S. (PLoS ONE 2012)
    275. What does the nature of the MECP2 mutation tell us about parental origin and recurrence risk in Rett syndrome? (PubMed id 22182064)1 Zhang J....Wu X. (Clin. Genet. 2012)
    276. Spontaneous recurrent mutations and a complex rearrangement in the MECP2 gene in the light of current models of mutagenesis. (PubMed id 22525432)1 Todorov T....Mitev V. (Mutat. Res. 2012)
    277. A critical and cell-autonomous role for MeCP2 in synaptic scaling up. (PubMed id 23015442)1 Blackman M.P....Turrigiano G.G. (J. Neurosci. 2012)
    278. Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation. (PubMed id 22129561)1 Honda S....Inazawa J. (J. Hum. Genet. 2012)
    279. Autonomic dysfunction with mutations in the gene that encodes methyl-CpG-binding protein 2: insights into Rett syndrome. (PubMed id 21316312)1 Lioy D.T....Bissonnette J.M. (amp 2011)
    280. Co-localization of the oncogenic transcription factor MYCN and the DNA methyl binding protein MeCP2 at genomic sites in neuroblastoma. (PubMed id 21731748)1 Murphy D.M....Stallings R.L. (PLoS ONE 2011)
    281. Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. (PubMed id 20479760)1 Piton A....Rouleau G.A. (Mol. Psychiatry 2011)
    282. Analysis of MECP2 gene copy number in boys with autism. (PubMed id 21531908)1 Xi C.Y....Gao H. (J. Child Neurol. 2011)
    283. Rett syndrome with and without detected MECP2 mutations: an attempt to redefine phenotypes. (PubMed id 20116947)1 Temudo T....Maciel P. (amp 2011)
    284. [Mutation analysis of methyl CpG-binding protein 2 gene(exon 3) in Hirschsprung disease and anorectal malformations]. (PubMed id 22030772)1 Wu M....Wang W.L. (Zhonghua Wei Chang Wai Ke Za Zhi 2011)
    285. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    286. Effects of creatine supplementation in Rett syndrome: a randomized, placebo-controlled trial. (PubMed id 21654506)1 Freilinger M....Bodamer O.A. (J Dev Behav Pediatr 2011)
    287. De novo MECP2 duplication in two females with random X-inactivation and moderate mental retardation. (PubMed id 21326285)1 Grasshoff U....Wieczorek D. (Eur. J. Hum. Genet. 2011)
    288. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    289. Complexities of Rett syndrome and MeCP2. (PubMed id 21632916)1 Samaco R.C. and Neul J.L. (J. Neurosci. 2011)
    290. The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome. (PubMed id 21824415)1 Miyake K....Kubota T. (BMC Neurosci 2011)
    291. Rett syndrome: exploring the autism link. (PubMed id 21825235)1 Percy A.K. (Arch. Neurol. 2011)
    292. Fa88-neuroprostanes mediate neurological severity in Rett syndrome. (PubMed id 21530498)1 Signorini C....Hayek J. ( international journal of clinical chemistry 2011)
    293. The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice. (PubMed id 22009741)1 Abuhatzira L....Bustin M. (J. Biol. Chem. 2011)
    294. High expression of MeCP2 in JC virus-infected cells of progressive multifocal leukoencephalopathy brains. (PubMed id 20497345)1 Shirai S....Tanaka S. (Neuropathology 2011)
    295. Change in gross motor abilities of girls and women with rett syndrome over a 3- to 4-year period. (PubMed id 21636779)1 Foley K.R....Leonard H. (J. Child Neurol. 2011)
    296. MeCP2 Rett mutations affect large scale chromatin organization. (PubMed id 21831886)1 Agarwal N....Cardoso M.C. (Hum. Mol. Genet. 2011)
    297. Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. (PubMed id 21372149)1 Cheung A.Y....Ellis J. (Hum. Mol. Genet. 2011)
    298. Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells. (PubMed id 21865261)1 Zhou Y....Lu Q. (Lupus 2011)
    299. Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes. (PubMed id 21278419)1 Yang C....Luger K. (Nucleic Acids Res. 2011)
    300. DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2). (PubMed id 21467044)1 Hansen J.C....Black B.E. (J. Biol. Chem. 2011)
    301. MECP2 duplications in six patients with complex sex chromosome rearrangements. (PubMed id 21119712)1 Breman A.M....Cheung S.W. (Eur. J. Hum. Genet. 2011)
    302. Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis. (PubMed id 21435439)1 Hu B....Phan S.H. (Am. J. Pathol. 2011)
    303. Oxidative stress in Rett syndrome: natural history, genotype, and variants. (PubMed id 21888765)1 Leoncini S....Hayek J. (Redox Rep. 2011)
    304. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    305. De novo deletion in MECP2 in a monozygotic twin pair: a case report. (PubMed id 21871116)1 Mittal K....BK T. (BMC Med. Genet. 2011)
    306. Two new Rett syndrome families and review of the literature: expanding the knowledge of MECP2 frameshift mutations. (PubMed id 21878110)1 Ravn K....Skjeldal O.H. (Orphanet J Rare Dis 2011)
    307. Mutational analysis of the MECP2 gene in Tunisian patients with Rett syndrome: a novel double mutation. (PubMed id 20631224)1 Fendri-Kriaa N....Fakhfakh F. (J. Child Neurol. 2010)
    308. The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis. (PubMed id 20504995)1 Forlani G....Landsberger N. (Hum. Mol. Genet. 2010)
    309. Genetic association between methyl-CpG binding protein 2 (MECP2) and primary Sjogren's syndrome. (PubMed id 20215141)1 Cobb B.L....Sawalha A.H. (Ann. Rheum. Dis. 2010)
    310. Epigenetic silencing of peroxisome proliferator-activated receptor I^ is a biomarker for colorectal cancer progression and adverse patients' outcome. (PubMed id 21151932)1 Pancione M....Colantuoni V. (PLoS ONE 2010)
    311. Updating the profile of C-terminal MECP2 deletions in Rett syndrome. (PubMed id 19914908)1 Bebbington A....Leonard H. (J. Med. Genet. 2010)
    312. Analysis of the parental origin of de novo MECP2 mutations and X chromosome inactivation in 24 sporadic patients with Rett syndrome in China. (PubMed id 20207612)1 Zhu X....Wu X. (J. Child Neurol. 2010)
    313. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (PLoS ONE 2010)
    314. Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells. (PubMed id 20385708)1 Hwang C.K....Loh H.H. (Mol. Pharmacol. 2010)
    315. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. (PubMed id 20368621)1 Szulwach K.E....Jin P. (J. Cell Biol. 2010)
    316. MeCP2 deficiency downregulates specific nuclear proteins that could be partially recovered by valproic acid in vitro. (PubMed id 20093853)1 Vecsler M....Gak E. (Epigenetics 2010)
    317. The role of calcium-dependent gene expression in autism spectrum disorders: lessons from MeCP2, Ube3a and beyond. (PubMed id 20956852)1 Qiu Z. and Cheng J. (Neurosignals 2010)
    318. L1 retrotransposition in neurons is modulated by MeCP2. (PubMed id 21085180)1 Muotri A.R....Gage F.H. (Nature 2010)
    319. Alternative polyadenylation of MeCP2: Influence of cis-acting elements and trans-acting factors. (PubMed id 20400852)1 Newnham C.M....Lutz C.S. (RNA Biol 2010)
    320. A novel transcriptional regulator of myelin gene expression: implications for neurodevelopmental disorders. (PubMed id 20697302)1 Vora P....Frost E.E. (Neuroreport 2010)
    321. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    322. Ocular MECP2 protein expression in patients with and without Rett syndrome. (PubMed id 20682201)1 Jain D....Eberhart C.G. (Pediatr. Neurol. 2010)
    323. Deciphering Rett syndrome with mouse genetics, epigenomics, and human neurons. (PubMed id 19900619)1 Tao J....Sun Y.E. (Int. Rev. Neurobiol. 2009)
    324. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    325. Autoimmunity and Klinefelter's syndrome: when men have two X chromosomes. (PubMed id 19464849)1 Sawalha A.H....Scofield R.H. (J. Autoimmun. 2009)
    326. MECP2 mutation in one of Rett's original patients. (PubMed id 19724012)1 Freilinger M....Haas O.A. (J. Med. Genet. 2009)
    327. Neurologic aspects of MECP2 gene duplication in male patients. (PubMed id 19664534)1 Echenne B....de Brouwer A.P. (Pediatr. Neurol. 2009)
    328. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. (PubMed id 20007372)1 Samaco R.C....Neul J.L. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    329. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    330. A moment's pause: putative nucleosome-based influences on MeCP2 regulation. (PubMed id 19898528)1 Thambirajah A.A. and AusiA^ J. (Biochem. Cell Biol. 2009)
    331. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    332. Mutations in the MECP2 gene are not a major cause of Rett syndrome-like or related neurodevelopmental phenotype in male patients. (PubMed id 19168818)1 Santos M....Maciel P. (J. Child Neurol. 2009)
    333. Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study. (PubMed id 19442287)4 Suarez-Gestal M....Gonzalez A. (amp 2009)
    334. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    335. Suppression of nonsense mutations in Rett syndrome by aminoglycoside antibiotics. (PubMed id 19190538)1 Brendel C....Huppke P. (Pediatr. Res. 2009)
    336. Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis. (PubMed id 19820693)1 Bracaglia G....Kilstrup-Nielsen C. (EMBO Rep. 2009)
    337. Interaction between the inner nuclear membrane lamin B receptor and the heterochromatic methyl binding protein, MeCP2. (PubMed id 19331822)1 Guarda A....Badaracco G. (Exp. Cell Res. 2009)
    338. Rett syndrome and the impact of MeCP2 associated transcriptional mechanisms on neurotransmission. (PubMed id 19058783)1 Monteggia L.M. and Kavalali E.T. (Biol. Psychiatry 2009)
    339. The first missense mutation causing Rett syndrome specifically affecting the MeCP2_e1 isoform. (PubMed id 19034540)1 Fichou Y....Bienvenu T. (Neurogenetics 2009)
    340. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    341. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    342. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    343. MECP2 genomic structure and function: insights from ENCODE. (PubMed id 18820302)1 Singh J....Ravine D. (Nucleic Acids Res. 2008)
    344. Multiple de novo mutations in the MECP2 gene. (PubMed id 18652533)1 Bunyan D.J. and Robinson D.O. (Genet. Test. 2008)
    345. Nonrecurrent MECP2 duplications mediated by genomic architecture-driven DNA breaks and break-induced replication repair. (PubMed id 18385275)1 Bauters M....Froyen G. (Genome Res. 2008)
    346. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (J. Proteome Res. 2008)
    347. The diagnosis of autism in a female: could it be Rett syndrome? (PubMed id 17684768)1 Young D.J....Leonard H. (Eur. J. Pediatr. 2008)
    348. Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions. (PubMed id 18499664)1 Ghosh R.P....Woodcock C.L. (J. Biol. Chem. 2008)
    349. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    350. MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively. (PubMed id 18295506)1 Palmer A....Ronnett G. (Mol. Cell. Neurosci. 2008)
    351. Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. (PubMed id 16763620)1 Mann J....Mann D.A. (Cell Death Differ. 2007)
    352. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    353. Homozygosity for MECP2 gene in a girl with classical Rett syndrome. (PubMed id 17881312)1 Karall D....Martorell L. (Eur J Med Genet 2007)
    354. MECP2 deletions and genotype-phenotype correlation in Rett syndrome. (PubMed id 17968969)1 Scala E....Ariani F. (Am. J. Med. Genet. A 2007)
    355. Comprehensive diagnosis of Rett's syndrome relying on genetic, epigenetic and expression evidence of deficiency of the methyl-CpG-binding protein 2 gene: study of a cohort of Israeli patients. (PubMed id 17407838)1 Petel-Galil Y....Gak E. (J. Med. Genet. 2007)
    356. MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome. (PubMed id 17660293)1 Nikitina T....Woodcock C.L. (J. Biol. Chem. 2007)
    357. An explanation for another familial case of Rett syndrome: maternal germline mosaicism. (PubMed id 17440498)1 VenAcncio M....Saraiva J.M. (Eur. J. Hum. Genet. 2007)
    358. Delineation of large deletions of the MECP2 gene in Rett syndrome patients, including a familial case with a male proband. (PubMed id 17712354)1 Hardwick S.A....Christodoulou J. (Eur. J. Hum. Genet. 2007)
    359. Correlation between clinical severity in patients with Rett syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X-chromosome inactivation. (PubMed id 16905679)1 Archer H....Clarke A. (J. Med. Genet. 2007)
    360. Sleep problems in Rett syndrome. (PubMed id 17531413)1 Young D....Leonard H. (amp 2007)
    361. Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin. (PubMed id 17101771)1 Nikitina T....Woodcock C.L. (Mol. Cell. Biol. 2007)
    362. Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters. (PubMed id 17634428)1 Wischnewski F....Schwarzenbach H. (Mol. Cancer Res. 2007)
    363. Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. (PubMed id 18042715)1 Yasui D.H....Lasalle J.M. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    364. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. (PubMed id 16399702)1 Moretti P....Zoghbi H.Y. (J. Neurosci. 2006)
    365. Comprehensive diagnosis of Rett's syndrome relying on genetic, epigenetic and expression evidence of deficiency of the methyl-CpG-binding protein 2 gene: study of a cohort of Israeli patients. (PubMed id 17142618)1 Petel-Galil Y....Gak E. (J. Med. Genet. 2006)
    366. Chromatin remodeling and neuronal function: exciting links. (PubMed id 16681803)1 Santos M....Maciel P. (Genes Brain Behav. 2006)
    367. The association between behavior and genotype in Rett syndrome using the Australian Rett Syndrome Database. (PubMed id 16389588)1 Robertson L....Leonard H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    368. Mechanisms of disease: neurogenetics of MeCP2 deficiency. (PubMed id 16932552)1 Francke U. (Nat Clin Pract Neurol 2006)
    369. Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. (PubMed id 16199017)1 Gemelli T....Monteggia L.M. (Biol. Psychiatry 2006)
    370. Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized. (PubMed id 16708070)1 Bienvenu T. and Chelly J. (Nat. Rev. Genet. 2006)
    371. Large deletions of the MECP2 gene in Chinese patients with classical Rett syndrome. (PubMed id 17026625)1 Pan H....Yu S. (Clin. Genet. 2006)
    372. Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. (PubMed id 16331260)1 Suzuki M....Oikawa T. (Oncogene 2006)
    373. A patient with classic Rett syndrome with a novel mutation in MECP2 exon 1. (PubMed id 17101000)1 Chunshu Y....Kubota T. (Clin. Genet. 2006)
    374. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (Cell 2006)
    375. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    376. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. (PubMed id 16251272)1 Young J.I....Zoghbi H.Y. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    377. MeCP2 in neurons: closing in on the causes of Rett syndrome. (PubMed id 15809268)1 Caballero I.M. and Hendrich B. (Hum. Mol. Genet. 2005)
    378. Mutations found within exon 1 of MECP2 in Danish patients with Rett syndrome. (PubMed id 15857422)1 Ravn K....Schwartz M. (Clin. Genet. 2005)
    379. MeCP2: the chromatin connection and beyond. (PubMed id 15959553)1 Zlatanova J. (Biochem. Cell Biol. 2005)
    380. Can we relate MeCP2 deficiency to the structural and chemical abnormalities in the Rett brain? (PubMed id 16182497)1 Armstrong D.D. (amp 2005)
    381. Rett syndrome: clinical review and genetic update. (PubMed id 15635068)1 Weaving L.S....Christodoulou J. (J. Med. Genet. 2005)
    382. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    383. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
    384. MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. (PubMed id 15322089)1 Klose R.J. and Bird A.P. (J. Biol. Chem. 2004)
    385. Odd MECP2-mutated Rett variant-long-term follow-up profile to age 25. (PubMed id 14623222)1 Hagberg B....Larsson G. (Eur. J. Paediatr. Neurol. 2003)
    386. Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression. (PubMed id 14647463)1 Suzuki M....Oikawa T. (Oncogene 2003)
    387. Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. (PubMed id 14633992)1 Ballestar E....Esteller M. (EMBO J. 2003)
    388. Patients with the R133C mutation: is their phenotype different from patients with Rett syndrome with other mutations? (PubMed id 12746406)1 Leonard H....Yamashita Y. (J. Med. Genet. 2003)
    389. De novo MECP2 mutation in a 46,XX male patient with Rett syndrome. (PubMed id 12481990)1 Maiwald R....Herkenrath P. (Neurogenetics 2002)
    390. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. (PubMed id 12399542)1 Lunyak V.V....Rosenfeld M.G. (Science 2002)
    391. MECP2 mutations in Swedish Rett syndrome clusters. (PubMed id 12081725)1 Xiang F....Anvret M. (Clin. Genet. 2002)
    392. MECP2 gene mutation analysis in Chinese patients with Rett syndrome. (PubMed id 12111643)1 Pan H....Shen Y. (Eur. J. Hum. Genet. 2002)
    393. Rett syndrome and MeCP2: linking epigenetics and neuronal function. (PubMed id 12442230)1 Shahbazian M.D. and Zoghbi H.Y. (Am. J. Hum. Genet. 2002)
    394. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    395. [Genotype-phenotype correlations in Rett syndrome: the study of Russian cohort of patients]. (PubMed id 12449561)1 Vorsanova S.G....Novikov P.V. (Zh Nevrol Psikhiatr Im S S Korsakova 2002)
    396. MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain. (PubMed id 12107440)1 Balmer D....LaSalle J.M. (Hum. Genet. 2002)
    397. Five novel frameshift mutations in exon 3 and 4 of the MECP2 gene identified in Rett patients: Consequences for the molecular diagnosis strategy. (PubMed id 11524737)1 Bienvenu T....Chelly J. (Hum. Mutat. 2001)
    398. A detailed analysis of the MECP2 gene: prevalence of recurrent mutations and gross DNA rearrangements in Rett syndrome patients. (PubMed id 11214906)1 Bourdon V....Jonveaux P. (Hum. Genet. 2001)
    399. Molecular analysis of Japanese patients with Rett syndrome: Identification of five novel mutations and genotype-phenotype correlation. (PubMed id 11524741)1 Yamada Y....Wakamatsu N. (Hum. Mutat. 2001)
    400. Evidence of somatic mosaicism for a MECP2 mutation in females with Rett syndrome: diagnostic implications. (PubMed id 11768391)1 Bourdon V....Jonveaux P. (J. Med. Genet. 2001)
    401. The Ski protein family is required for MeCP2-mediated transcriptional repression. (PubMed id 11441023)1 Kokura K....Ishii S. (J. Biol. Chem. 2001)
    402. DHPLC analysis of the MECP2 gene in Italian Rett patients. (PubMed id 11462237)1 Nicolao P....Gasparini P. (Hum. Mutat. 2001)
    403. MECP2 mutations in Danish patients with Rett syndrome: high frequency of mutations but no consistent correlations with clinical severity or with the X chromosome inactivation pattern. (PubMed id 11313756)1 Nielsen J.B....Tommerup N. (Eur. J. Hum. Genet. 2001)
    404. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (Genome Res. 2000)
    405. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)
    406. Somatic mutation in MECP2 as a non-fatal neurodevelopmental disorder in males. (PubMed id 11022934)1 Clayton-Smith J....Black G.C. (Lancet 2000)
    407. Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. (PubMed id 10773092)1 Yu F....StrAotling W.H. (Nucleic Acids Res. 2000)
    408. Preserved speech variant is allelic of classic Rett syndrome. (PubMed id 10854091)1 De Bona C....Renieri A. (Eur. J. Hum. Genet. 2000)
    409. XLMR syndrome characterized by multiple respiratory infections, hypertelorism, severe CNS deterioration and early death localizes to distal Xq28. (PubMed id 10398236)1 Lubs H....Arena F. (Am. J. Med. Genet. 1999)
    410. X-linked nonspecific mental retardation (MRX16) mapping to distal Xq28: linkage study and neuropsychological data in a large family. (PubMed id 10232754)1 Gendrot C....Moraine C. (Am. J. Med. Genet. 1999)
    411. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. (PubMed id 9620804)1 Nan X....Bird A. (Nature 1998)
    412. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. (PubMed id 9620779)1 Jones P.L....Wolffe A.P. (Nat. Genet. 1998)
    413. Cortical reflex myoclonus in Rett syndrome. (PubMed id 9546328)1 Guerrini R....Sartucci F. (Ann. Neurol. 1998)
    414. A new X linked recessive syndrome of mental retardation and mild dysmorphism maps to Xq28. (PubMed id 9222958)1 Pai G.S....Schwartz C.E. (J. Med. Genet. 1997)
    415. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. (PubMed id 9171351)1 Bedford M.T....Leder P. (EMBO J. 1997)
    416. X-linked severe mental retardation and a progressive neurological disorder in a Belgian family: clinical and genetic studies. (PubMed id 9377804)1 Claes S....Fryns J.P. (Clin. Genet. 1997)
    417. The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. (PubMed id 8563762)1 Tate P....Bird A. (Nat. Genet. 1996)
    418. Autism Spectrum Disorders (PubMed id 20301615)1 Pagon R.A....Stephens K. (1993)
    419. Angelman Syndrome (PubMed id 20301323)1 Pagon R.A....Stephens K. (1993)
    420. MECP2 Duplication Syndrome (PubMed id 20301461)1 Pagon R.A....Stephens K. (1993)
    421. MECP2-Related Disorders (PubMed id 20301670)1 Pagon R.A....Stephens K. (1993)
    422. The significance of TSH values measured in a sensitive assay in the follow-up of hyperthyroid patients treated with radioiodine. (PubMed id 1569166)1 Davies P.H....Sheppard M.C. (J. Clin. Endocrinol. Metab. 1992)
    423. (PubMed id 19119840)4 
    424. Phosphorylation of methyl-CpG binding protein 2 (MeCP2) regulates the intracellular localization during neuronal cell differentiation. (PubMed id 17052801)9 Miyake K. and Nagai K. (Neurochem. Int. 2007)
    425. (PubMed id 17965613)9 
    426. Expression of methyl CpG binding protein 2 (Mecp2) during the postnatal development of the mouse brainstem. (PubMed id 18761004)9 Dura E....Roux J.C. (Brain Res. 2008)
    427. Rett syndrome: the complex nature of a monogenic disease. (PubMed id 12750821)9 Renieri A....Cambi F. (J. Mol. Med. 2003)
    428. Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. (PubMed id 14734626)9 Samaco R.C....LaSalle J.M. (Hum. Mol. Genet. 2004)
    429. Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. (PubMed id 11532982)9 LaSalle J.M....Greco C.M. (Hum. Mol. Genet. 2001)
    430. Real-time quantitative PCR as a routine method for screening large rearrangements in Rett syndrome: Report of one case of MECP2 deletion and one case of MECP2 duplication. (PubMed id 15241799)9 Ariani F....Renieri A. (Hum. Mutat. 2004)
    431. A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. (PubMed id 18321864)9 Samaco R.C....Neul J.L. (Hum. Mol. Genet. 2008)
    432. MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products. (PubMed id 18506103)9 Yakabe S....Mukai T. (amp 2008)
    433. Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations. (PubMed id 12418965)9 Traynor J....Francke U. (BMC Med. Genet. 2002)
    434. Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer. (PubMed id 11710831)9 MA1ller-Tidow C....Serve H. (Br. J. Cancer 2001)
    435. MeCP2 post-translational regulation through PEST domains: two novel hypotheses: potential relevance and implications for Rett syndrome. (PubMed id 19319913)9 Thambirajah A.A....AusiA^ J. (Bioessays 2009)
    436. MECP2 promoter methylation and X chromosome inactivation in autism. (PubMed id 19132145)9 Nagarajan R.P....LaSalle J.M. (Autism Res 2008)
    437. Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2. (PubMed id 17371874)9 Adams V.H....Hansen J.C. (J. Biol. Chem. 2007)
    438. X-Chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2-/+ mouse brain. (PubMed id 15115765)9 Braunschweig D....LaSalle J.M. (Hum. Mol. Genet. 2004)
    439. Early environmental enrichment moderates the behavioral and synaptic phenotype of MeCP2 null mice. (PubMed id 20172507)9 Lonetti G....Pizzorusso T. (Biol. Psychiatry 2010)
    440. Recent advances in MeCP2 structure and function. (PubMed id 19234536)9 Hite K.C....Hansen J.C. (Biochem. Cell Biol. 2009)
    441. Methyl CpG-binding protein 2 (a mutation of which causes Rett syndrome) directly regulates insulin-like growth factor binding protein 3 in mouse and human brains. (PubMed id 17278996)9 Itoh M....Goto Y. (J. Neuropathol. Exp. Neurol. 2007)
    442. The impact of MECP2 mutations in the expression patterns of Rett syndrome patients. (PubMed id 15549394)9 Ballestar E....Esteller M. (Hum. Genet. 2005)
    443. A case of Rett syndrome from Ukraine--clinical diagnosis confirmed by mutation analysis of the MECP2 gene. (PubMed id 15633890)9 Bzduch V....Martasek P. (Bratisl Lek Listy 2004)
    444. Multiplex ligation-dependent probe amplification (MLPA) detects large deletions in the MECP2 gene of Swedish Rett syndrome patients. (PubMed id 15000811)9 Erlandson A....WahlstrAPm J. (Genet. Test. 2003)
    445. Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis. (PubMed id 12727440)9 Cohen D.R....Ronnett G.V. (Mol. Cell. Neurosci. 2003)
    446. Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. (PubMed id 12788925)9 Georgel P.T....Hansen J.C. (J. Biol. Chem. 2003)
    447. Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. (PubMed id 20188665)9 Skene P.J....Bird A.P. (Mol. Cell 2010)
    448. Rett syndrome: from the gene to the disease. (PubMed id 18948693)9 Matijevic T....Pavelic J. (Eur. Neurol. 2009)
    449. Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo. (PubMed id 18334558)9 Kumar A....Schanen N.C. (J. Cell. Sci. 2008)
    450. Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. (PubMed id 18817733)9 Fyffe S.L....Zoghbi H.Y. (Neuron 2008)
    451. MECP2 mutations are an infrequent cause of mental retardation associated with neurological problems in male patients. (PubMed id 16376510)9 Moog U....Schrander-Stumpel C. (amp 2006)
    452. MeCP2 dysfunction in Rett syndrome and related disorders. (PubMed id 16647848)9 Moretti P. and Zoghbi H.Y. (amp 2006)
    453. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. (PubMed id 17046689)9 Zhou Z....Greenberg M.E. (Neuron 2006)
    454. Rett syndrome: methyl-CpG-binding protein 2 mutations and phenotype-genotype correlations. (PubMed id 11180222)9 Amir R.E. and Zoghbi H.Y. (Am. J. Med. Genet. 2000)
    455. ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. (PubMed id 20159591)9 Kernohan K.D....BAcrubAc N.G. (Dev. Cell 2010)
    456. Mecp2-null mice provide new neuronal targets for Rett syndrome. (PubMed id 18989361)9 Urdinguio R.G....Esteller M. (PLoS ONE 2008)
    457. Deleterious mutations in exon 1 of MECP2 in Rett syndrome. (PubMed id 16829352)9 Quenard A....Philippe C. (Eur J Med Genet 2006)
    458. DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. (PubMed id 16137622)9 Klose R.J....Bird A.P. (Mol. Cell 2005)
    459. Classic Rett syndrome in a boy with R133C mutation of MECP2. (PubMed id 16122633)9 Masuyama T....Kondo I. (amp 2005)
    460. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. (PubMed id 15615769)9 Samaco R.C....LaSalle J.M. (Hum. Mol. Genet. 2005)
    461. Chromosomal regulation by MeCP2: structural and enzymatic considerations. (PubMed id 15338046)9 Bowen N.J....Wade P.A. (Cell. Mol. Life Sci. 2004)
    462. A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos. (PubMed id 14536082)9 Stancheva I....Meehan R.R. (Mol. Cell 2003)
    463. MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland. (PubMed id 11965543)9 Billard L.M....Dante R. (Oncogene 2002)
    464. MECP2 gene analysis in classical Rett syndrome and in patients with Rett-like features. (PubMed id 11245712)9 Auranen M....JAorvelAo I. (Neurology 2001)
    465. Molecular genetics of Rett syndrome and clinical spectrum of MECP2 mutations. (PubMed id 11262731)9 Shahbazian M.D. and Zoghbi H.Y. (Curr. Opin. Neurol. 2001)
    466. Rett syndrome from quintuple and triple deletions within the MECP2 deletion hotspot region. (PubMed id 11453972)9 Lebo R.V....Milunsky A. (Clin. Genet. 2001)
    467. Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. (PubMed id 11738862)9 Van den Veyver I.B. and Zoghbi H.Y. (amp 2001)
    468. Rett syndrome: a surprising result of mutation in MECP2. (PubMed id 11005791)9 Dragich J....Schanen C. (Hum. Mol. Genet. 2000)
    469. APOE epsilon4: a potential modulation factor in Rett syndrome. (PubMed id 20139413)9 Zahorakova D....Martasek P. (J. Child Neurol. 2010)
    470. MBD2 and MeCP2 regulate distinct transitions in the stage-specific differentiation of olfactory receptor neurons. (PubMed id 20188178)9 Macdonald J.L....Roskams A.J. (Mol. Cell. Neurosci. 2010)
    471. Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. (PubMed id 19217433)9 Larimore J.L....Pozzo-Miller L. (Neurobiol. Dis. 2009)
    472. Temporal shift in methyl-CpG binding protein 2 expression in a mouse model of Rett syndrome. (PubMed id 16549272)9 Metcalf B.M....Blue M.E. (Neuroscience 2006)
    473. The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. (PubMed id 15809347)9 Zhao W....Mukai T. (J. Biochem. 2005)
    474. Molecular diagnosis of Rett syndrome. (PubMed id 16225827)9 Huppke P. and GAortner J. (J. Child Neurol. 2005)
    475. Rett syndrome. (PubMed id 15791137)9 Segawa M. and Nomura Y. (Curr. Opin. Neurol. 2005)
    476. Rett syndrome: clinical and molecular update. (PubMed id 15548931)9 Percy A.K. and Lane J.B. (Curr. Opin. Pediatr. 2004)
    477. Autonomic dysfunction in mental retardation and spastic paraparesis with MECP2 mutation. (PubMed id 15704871)9 Dotti M.T....Federico A. (J. Child Neurol. 2004)
    478. Influence of MECP2 gene mutation and X-chromosome inactivation on the Rett syndrome phenotype. (PubMed id 15526954)9 Chae J.H....Kim K.J. (J. Child Neurol. 2004)
    479. Mutation analysis of MECP2 and clinical characterization in Korean patients with Rett syndrome. (PubMed id 11913567)9 Chae J.H....Kim K.J. (J. Child Neurol. 2002)
    480. Mutation analysis in Rett syndrome. (PubMed id 11960578)9 Milunsky J.M....Milunsky A. (Genet. Test. 2001)
    481. Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA. (PubMed id 10852707)9 Ballestar E....Wolffe A.P. (Biochemistry 2000)
    482. Functional consequences of Rett syndrome mutations on human MeCP2. (PubMed id 11058114)9 Yusufzai T.M. and Wolffe A.P. (Nucleic Acids Res. 2000)
    483. (PubMed id 19017163)9 
    484. MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons. (PubMed id 20025874)9 Kishi N. and Macklis J.D. (Exp. Neurol. 2010)
    485. Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice. (PubMed id 20392952)9 Kline D.D....Katz D.M. (J. Neurosci. 2010)
    486. Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression. (PubMed id 20513142)9 Zweier M....Rauch A. (Hum. Mutat. 2010)
    487. Allele drop-out in the MECP2 gene due to G-quadruplex and i-motif sequences when using polymerase chain reaction-based diagnosis for Rett syndrome. (PubMed id 20384458)9 Saunders C.J....Bi C. (Genet Test Mol Biomarkers 2010)
    488. The common BDNF polymorphism may be a modifier of disease severity in Rett syndrome. (PubMed id 19349604)9 Zeev B.B....Christodoulou J. (Neurology 2009)
    489. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. (PubMed id 19444718)9 Lei W....Lu Q. (Scand. J. Rheumatol. 2009)
    490. De-novo 2.15 Mb terminal Xq duplication involving MECP2 but not L1CAM gene in a male patient with mental retardation. (PubMed id 19090026)9 Velinov M....Brown W.T. (Clin. Dysmorphol. 2009)
    491. Altered expression of Autism-associated genes in the brain of Fragile X mouse model. (PubMed id 19138667)9 Zhang A....El Idrissi A. (Biochem. Biophys. Res. Commun. 2009)
    492. CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail. (PubMed id 18701457)9 Rusconi L....Landsberger N. (J. Biol. Chem. 2008)
    493. Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. (PubMed id 18492797)9 Ma L.C....Chang J.Y. (Mol. Pharmacol. 2008)
    494. Comparison of global DNA methylation profiles in replicative versus premature senescence. (PubMed id 18723031)9 Zhang W....Zhuang Z. (Life Sci. 2008)
    495. Rett syndrome. (PubMed id 17562589)9 Ben Zeev Ghidoni B. (Child Adolesc Psychiatr Clin N Am 2007)
    496. Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice. (PubMed id 17936729)9 Lawson-Yuen A....Coyle J.T. (Brain Res. 2007)
    497. Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR). (PubMed id 17370310)9 Chan P.A....Greenblatt M.S. (Hum. Mutat. 2007)
    498. DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. (PubMed id 17065238)9 Kundakovic M....Grayson D.R. (Mol. Pharmacol. 2007)
    499. Clinical profiles of four patients with Rett syndrome carrying a novel exon 1 mutation or genomic rearrangement in the MECP2 gene. (PubMed id 16630165)9 Bartholdi D....MA!tyA!s G. (Clin. Genet. 2006)
    500. Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. (PubMed id 16052033)9 Auriol E....Dante R. (Nucleic Acids Res. 2005)
    501. Detection of heterozygous deletions and duplications in the MECP2 gene in Rett syndrome by Robust Dosage PCR (RD-PCR). (PubMed id 15841480)9 Shi J....Sommer S.S. (Hum. Mutat. 2005)
    502. CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders. (PubMed id 16330482)9 Lin C....Rosner M.R. (Hum. Mol. Genet. 2005)
    503. Methyl-CpG binding proteins in the nervous system. (PubMed id 15857580)9 Fan G. and Hutnick L. (Cell Res. 2005)
    504. MECP2 abnormality phenotypes: clinicopathologic area with broad variability. (PubMed id 16225826)9 Erlandson A. and Hagberg B. (J. Child Neurol. 2005)
    505. Methyl-CpG binding protein 2 gene (MECP2) variations in Japanese patients with Rett syndrome: pathological mutations and polymorphisms. (PubMed id 15737703)9 Fukuda T....Kondo I. (amp 2005)
    506. MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma. (PubMed id 12824891)9 Darwanto A....Kitazawa S. (Cancer Sci. 2003)
    507. Gross rearrangements in the MECP2 gene in three patients with Rett syndrome: implications for routine diagnosis of Rett syndrome. (PubMed id 12872251)9 Schollen E....Matthijs G. (Hum. Mutat. 2003)
    508. Sporadic case of fatal encephalopathy with neonatal onset associated with a T158M missense mutation in MECP2. (PubMed id 12719401)9 Lynch S.A....Ravine D. (Arch. Dis. Child. Fetal Neonatal Ed. 2003)
    509. Effects of MECP2 mutation type, location and X-inactivation in modulating Rett syndrome phenotype. (PubMed id 12655490)9 Weaving L.S....Christodoulou J. (Am. J. Med. Genet. A 2003)
    510. MECP2 mutations in Israel: implications for molecular analysis, genetic counseling, and prenatal diagnosis in Rett syndrome. (PubMed id 12325033)9 Yaron Y....Orr-Urtreger A. (Hum. Mutat. 2002)
    511. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. (PubMed id 12160743)9 Shahbazian M....Zoghbi H. (Neuron 2002)
    512. Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. (PubMed id 12388720)9 Krithivas A....Hayward S.D. (J. Virol. 2002)
    513. Deletion screening by fluorescence in situ hybridization in Rett syndrome patients. (PubMed id 11755104)9 Bourdon V....Jonveaux P. (Ann. Genet. 2001)
    514. R133C and R168X mutations in Japanese Rett syndrome patients: a caution for misdiagnosis. (PubMed id 11738863)9 Amano K....Yamakawa K. (amp 2001)
    515. The role of different X-inactivation pattern on the variable clinical phenotype with Rett syndrome. (PubMed id 11738865)9 Ishii T....Oki J. (amp 2001)
    516. Preserved speech variants of the Rett syndrome: molecular and clinical analysis. (PubMed id 11746022)9 Zappella M....Renieri A. (Am. J. Med. Genet. 2001)
    517. Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA. (PubMed id 11371345)9 Ohki I....Shirakawa M. (Cell 2001)
    518. Closely related Swedish Rett Syndrome females - none with MECP2 mutation revealed. (PubMed id 11571704)9 Xiang F....Hagberg B. (Neuropediatrics 2001)
    519. Spectrum of MECP2 mutations in Rett syndrome. (PubMed id 11738860)9 Lee S.S....Francke U. (amp 2001)
    520. Methyl-CpG-binding protein 2 mutations in Rett syndrome. (PubMed id 10826991)9 Van den Veyver I.B. and Zoghbi H.Y. (amp 2000)
    521. Two affected boys in a Rett syndrome family: clinical and molecular findings. (PubMed id 11071498)9 Villard L....Fontes M. (Neurology 2000)
    522. Active repression of methylated genes by the chromosomal protein MBD1. (PubMed id 10648624)9 Ng H.-H.... Bird A. (Mol. Cell. Biol. 2000)
    523. Novel de novo nonsense mutation of MECP2 in a patient with Rett syndrome. (PubMed id 10737989)9 Kim S.J. and Cook E.H. (Hum. Mutat. 2000)
    524. Epilepsy and mental retardation limited to females with PCDH19 mutations can present de novo or in single generation families. (PubMed id 19752159)9 Hynes K.... Scheffer I.E. (J. Med. Genet. 2010)
    525. Cyclin-dependent kinase-like 5 (CDKL5) mutation screening in Rett syndrome and related disorders. (PubMed id 20397747)9 White R....Christodoulou J. (Twin Res Hum Genet 2010)
    526. Chromatin modifiers, cognitive disorders, and imprinted genes. (PubMed id 20159587)9 Cunningham M.D....Pfeifer K. (Dev. Cell 2010)
    527. Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity. (PubMed id 19781662)9 Katryniok C....Steinhilber D. (Biochim. Biophys. Acta 2010)
    528. Four unrelated patients with Lubs X-linked mental retardation syndrome and different Xq28 duplications. (PubMed id 20082459)9 Bartsch O....Haaf T. (Am. J. Med. Genet. A 2010)
    529. Epilepsy and the natural history of Rett syndrome. (PubMed id 20231667)9 Glaze D.G....Lee H.S. (Neurology 2010)
    530. The 2q23.1 microdeletion syndrome: clinical and behavioural phenotype. (PubMed id 19809484)9 van Bon B.W....de Vries B.B. (Eur. J. Hum. Genet. 2010)
    531. CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression. (PubMed id 20079429)9 Zelko I.N....Folz R.J. (amp 2010)
    532. Effects of sedation on auditory brainstem response in Rett syndrome. (PubMed id 20399386)9 Pillion J.P....Naidu S. (Pediatr. Neurol. 2010)
    533. Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation. (PubMed id 20163734)9 Jentarra G.M....Narayanan V. (BMC Neurosci 2010)
    534. Acquired microcephaly, regression of milestones, mitochondrial dysfunction, and episodic rigidity in a 46,XY male with a de novo MECP2 gene mutation. (PubMed id 20142466)9 Condie J....Wainwright M.S. (J. Child Neurol. 2010)
    535. Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. (PubMed id 19897480)9 Kuhn D.E....Elton T.S. (J. Biol. Chem. 2010)
    536. Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. (PubMed id 19856314)9 Pandey M....Gupta S. (Int. J. Cancer 2010)
    537. Expression analysis and mutation detection of DLX5 and DLX6 in autism. (PubMed id 19195802)9 Nakashima N....Momoi M.Y. (amp 2010)
    538. A novel p.Arg970X mutation in the last exon of the CDKL5 gene resulting in late-onset seizure disorder. (PubMed id 19428276)9 Psoni S....Kitsiou-Tzeli S. (Eur. J. Paediatr. Neurol. 2010)
    539. Biogenic amines in Rett syndrome: the usual suspects. (PubMed id 19851857)9 Roux J.C. and Villard L. (Behav. Genet. 2010)
    540. Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. (PubMed id 19661918)9 Luo S.W....Xiong W.C. (EMBO J. 2009)
    541. Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. (PubMed id 19620278)9 Jeong S....Jones P.A. (Mol. Cell. Biol. 2009)
    542. The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes. (PubMed id 19029285)9 Kundakovic M....Grayson D.R. (Mol. Pharmacol. 2009)
    543. [X-linked alpha-thalassemia/mental retardation syndrome]. (PubMed id 19489441)9 Wada T. (Rinsho Byori 2009)
    544. Xq28 duplication presenting with intestinal and bladder dysfunction and a distinctive facial appearance. (PubMed id 18854860)9 Clayton-Smith J....Donnai D. (Eur. J. Hum. Genet. 2009)
    545. Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells. (PubMed id 19116135)9 Papait R....Cattaneo E. (Biochem. Biophys. Res. Commun. 2009)
    546. Could autism with mental retardation result from digenism and frequent de novo mutations? (PubMed id 19160128)9 Moraine C....Gomot M. (World J. Biol. Psychiatry 2009)
    547. Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2. (PubMed id 19427855)9 Tsujimura K....Nakashima K. (Exp. Neurol. 2009)
    548. CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery. (PubMed id 19740913)9 Ricciardi S....Broccoli V. (Hum. Mol. Genet. 2009)
    549. Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells. (PubMed id 18952593)9 Chatagnon A....Dante R. (Carcinogenesis 2009)
    550. Lessons from two human chromatin diseases, ICF syndrome and Rett syndrome. (PubMed id 18786650)9 Matarazzo M.R....D'Esposito M. (amp 2009)
    551. A MECP2 mutation in a highly conserved aminoacid causing mental retardation in a male. (PubMed id 18678449)9 Campos M....Pimentel M.M. (amp 2009)
    552. Enhanced dense core granule function and adrenal hypersecretion in a mouse model of Rett syndrome. (PubMed id 19674087)9 Ladas T....Katz D.M. (Eur. J. Neurosci. 2009)
    553. A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition. (PubMed id 19383923)9 Pampalakis G....Sotiropoulou G. (Cancer Res. 2009)
    554. [Systemic control of the molecular, cell, and epigenetic mechanisms of long-lasting consequences of stress]. (PubMed id 19382685)9 BaA-do A.I....Savenko I.u.N. (Genetika 2009)
    555. Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation. (PubMed id 19012748)9 Ward B.C....Berger-Sweeney J.E. (J. Neurochem. 2009)
    556. Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. (PubMed id 19208815)9 Tropea D....Sur M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    557. Regulation of oestrogen receptor gene expression: new insights and novel mechanisms. (PubMed id 19207817)9 Wilson M.E. and Westberry J.M. (J. Neuroendocrinol. 2009)
    558. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. (PubMed id 19109157)9 Lal G....Bromberg J.S. (J. Immunol. 2009)
    559. DNA methylation and methyl-CpG binding proteins: developmental requirements and function. (PubMed id 19506892)9 BogdanoviA8 O. and Veenstra G.J. (Chromosoma 2009)
    560. A novel mutation in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene associated with a severe Rett phenotype. (PubMed id 19253388)9 Sprovieri T.... Quattrone A. (Am. J. Med. Genet. A 2009)
    561. Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome. (PubMed id 18600331)9 Doppler E....Masliah E. (Acta Neuropathol. 2008)
    562. Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells. (PubMed id 18204074)9 Ji W....Zhuang Z. (Carcinogenesis 2008)
    563. The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4. (PubMed id 18922874)9 Lin A....Frappier L. (J. Virol. 2008)
    564. MeCP2 binding to DNA depends upon hydration at methyl-CpG. (PubMed id 18313390)9 Ho K.L....Walkinshaw M.D. (Mol. Cell 2008)
    565. Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes. (PubMed id 18310117)9 Jiang Y....Wang S. (J. Exp. Biol. 2008)
    566. Abnormal DNA methylation in T cells from patients with subacute cutaneous lupus erythematosus. (PubMed id 18644019)9 Luo Y....Lu Q. (Br. J. Dermatol. 2008)
    567. The methyl-CpG-binding protein MeCP2 and neurological disease. (PubMed id 18631120)9 Bird A. (Biochem. Soc. Trans. 2008)
    568. Different-sized duplications of Xq28, including MECP2, in three males with mental retardation, absent or delayed speech, and recurrent infections. (PubMed id 18165974)9 Smyk M....Bocian E. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    569. Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. (PubMed id 18032561)9 Medrihan L....Zhang W. (J. Neurophysiol. 2008)
    570. Analysis of X chromosome inactivation in autism spectrum disorders. (PubMed id 18361425)9 Gong X....Bourgeron T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    571. [Autism, epilepsy and genetics]. (PubMed id 18302128)9 MuA+oz-Yunta J.A....Manchado F. (Rev Neurol 2008)
    572. Epigenetic silencers are enriched in dormant desert frog muscle. (PubMed id 18369641)9 Hudson N.J....Lehnert S.A. (J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 2008)
    573. Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. (PubMed id 18550052)9 Kim B....Niles L.P. (Eur. J. Pharmacol. 2008)
    574. Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism. (PubMed id 19096215)9 Xu S....Fan Y.S. (Cytogenet. Genome Res. 2008)
    575. In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. (PubMed id 18433299)9 Xiao P....Deng H.W. (J. Bone Miner. Res. 2008)
    576. Complications in the assignment of 14 and 28 Da mass shift detected by mass spectrometry as in vivo methylation from endogenous proteins. (PubMed id 18247584)9 Jung S.Y....Qin J. (Anal. Chem. 2008)
    577. Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation. (PubMed id 18184782)9 Nelson E.D....Monteggia L.M. (J. Neurosci. 2008)
    578. Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome. (PubMed id 17439480)9 Roux J.C....Villard L. (Eur. J. Neurosci. 2007)
    579. Epigenetics and Neural developmental disorders: Washington DC, September 18 and 19, 2006. (PubMed id 17965627)9 Zhao X....Jin P. (Epigenetics 2007)
    580. MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). (PubMed id 17573714)9 Burmistrova O.A....Rogaev E.I. (Biochemistry Mosc. 2007)
    581. Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome. (PubMed id 16996699)9 Tsai S.J. (Med. Hypotheses 2007)
    582. Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. (PubMed id 17408664)9 Park I.Y....Lee Y.I. (Gastroenterology 2007)
    583. Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer. (PubMed id 17464338)9 Sansom O.J....Clarke A.R. (Nat Clin Pract Oncol 2007)
    584. Detection of genomic copy number changes in patients with idiopathic mental retardation by high-resolution X-array-CGH: important role for increased gene dosage of XLMR genes. (PubMed id 17546640)9 Froyen G....Marynen P. (Hum. Mutat. 2007)
    585. Herpesvirus saimiri episomal persistence is maintained via interaction between open reading frame 73 and the cellular chromosome-associated protein MeCP2. (PubMed id 17267510)9 Griffiths R. and Whitehouse A. (J. Virol. 2007)
    586. MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein? (PubMed id 17317146)9 Chadwick L.H. and Wade P.A. (amp 2007)
    587. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the &quot;LEARn&quot; model (latent early-life associated regulation) may explain the triggering of AD. (PubMed id 17430250)9 Lahiri D.K....Zawia N.H. (Curr Alzheimer Res 2007)
    588. Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. (PubMed id 17140695)9 Lin R.K....Wang Y.C. (Lung Cancer 2007)
    589. Folate receptor autoantibodies and spinal fluid 5-methyltetrahydrofolate deficiency in Rett syndrome. (PubMed id 18058624)9 Ramaekers V.T....Quadros E.V. (Neuropediatrics 2007)
    590. Imprinting status of paternally imprinted DLX5 gene in Japanese patients with Rett syndrome. (PubMed id 17363207)9 Itaba-Matsumoto N....Nanba E. (amp 2007)
    591. Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events. (PubMed id 17133344)9 Matarazzo M.R....D'Esposito M. (J. Cell. Physiol. 2007)
    592. Molecular epigenetics of Angelman syndrome. (PubMed id 17347796)9 Lalande M. and Calciano M.A. (Cell. Mol. Life Sci. 2007)
    593. Coinheritance of mutated SMN1 and MECP2 genes in a child with phenotypic features of spinal muscular atrophy (SMA) type II and Rett syndrome. (PubMed id 17276711)9 Voutoufianakis S....Fryssira H. (Eur. J. Paediatr. Neurol. 2007)
    594. Assistive technology and supplementary treatment for individuals with Rett syndrome. (PubMed id 17619776)9 Lotan M. (ScientificWorldJournal 2007)
    595. Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. (PubMed id 17698632)9 Jamaluddin M.D....Wang H. (Blood 2007)
    596. Mbd2 contributes to DNA methylation-directed repression of the Xist gene. (PubMed id 17353271)9 Barr H....Bird A. (Mol. Cell. Biol. 2007)
    597. Lithium and antidepressants: potential agents for the treatment of Rett syndrome. (PubMed id 16584849)9 Tsai S.J. (Med. Hypotheses 2006)
    598. [Rett syndrome: a diagnostic, clinical and molecular update]. (PubMed id 16506134)9 Tejada M.I. (Rev Neurol 2006)
    599. Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis. (PubMed id 17998807)9 Gray S.G. and Dangond F. (Epigenetics 2006)
    600. A new cohort of MECP2 mutation screening in unexplained mental retardation: careful re-evaluation is the best indicator for molecular diagnosis. (PubMed id 16763963)9 Donzel-Javouhey A....Faivre L. (Am. J. Med. Genet. A 2006)
    601. Aberrant promoter methylation of the ABCG2 gene in renal carcinoma. (PubMed id 16954373)9 To K.K....Bates S.E. (Mol. Cell. Biol. 2006)
    602. CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2. (PubMed id 16786000)9 Pulukuri S.M. and Rao J.S. (Oncogene 2006)
    603. Maternal origin of a novel C-terminal truncation mutation in CDKL5 causing a severe atypical form of Rett syndrome. (PubMed id 16813600)9 Nectoux J....Bienvenu T. (Clin. Genet. 2006)
    604. Widened clinical spectrum of the Q128P MECP2 mutation in Rett syndrome. (PubMed id 15875198)9 Giampietro P.F....Roa B.B. (Childs Nerv Syst 2006)
    605. Rett syndrome. A review with emphasis on clinical characteristics and intervention. (PubMed id 17160339)9 Lotan M. and Ben-Zeev B. (ScientificWorldJournal 2006)
    606. The genetics of mental retardation. (PubMed id 16987873)9 Raymond F.L. and Tarpey P. (Hum. Mol. Genet. 2006)
    607. A new paradigm for West syndrome based on molecular and cell biology. (PubMed id 16806828)9 Kato M. (Epilepsy Res. 2006)
    608. Multiplex protocol suitable for screening for MECP2 mutations in girls with mental retardation. (PubMed id 16510438)9 Carvalho C.M....Pena S.D. (Clin. Chem. 2006)
    609. Engineering a high-affinity methyl-CpG-binding protein. (PubMed id 16893950)9 JA...Bird A.P. (Nucleic Acids Res. 2006)
    610. hMLH1 promoter methylation and silencing in primary endometrial cancers are associated with specific alterations in MBDs occupancy and histone modifications. (PubMed id 16701802)9 Xiong Y....Jiang S.W. (Gynecol. Oncol. 2006)
    611. Forensic issues and possible mechanisms of sudden death in Rett syndrome. (PubMed id 16263320)9 Byard R.W. (J Clin Forensic Med 2006)
    612. Very mild cases of Rett syndrome with skewed X inactivation. (PubMed id 16690727)9 Huppke P....GAortner J. (J. Med. Genet. 2006)
    613. Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. (PubMed id 16329111)9 Majumder S....Ghoshal K. (J. Cell. Biochem. 2006)
    614. The diagnostic utility of a genetics evaluation in children with pervasive developmental disorders. (PubMed id 16418599)9 Abdul-Rahman O.A. and Hudgins L. (Genet. Med. 2006)
    615. The ups and downs of BDNF in Rett syndrome. (PubMed id 16446133)9 Sun Y.E. and Wu H. (Neuron 2006)
    616. [Non-specific X-linked mental retardation]. (PubMed id 16506138)9 MartA-nez-Castellano F. (Rev Neurol 2006)
    617. Methylation mediated silencing of TMS1/ASC gene in prostate cancer. (PubMed id 16848908)9 Das P.M....Singal R. (Mol. Cancer 2006)
    618. Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation. (PubMed id 16935860)9 Bertani I.... Kilstrup-Nielsen C. (J. Biol. Chem. 2006)
    619. X linked mental retardation: a clinical guide. (PubMed id 16118346)9 Raymond F.L. (J. Med. Genet. 2006)
    620. SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein. (PubMed id 17036333)9 Wang Z....Lim S.H. (Int. J. Cancer 2006)
    621. Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. (PubMed id 15657354)9 Danam R.P....Harris L.C. (Mol. Cancer Ther. 2005)
    622. Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. (PubMed id 16354910)9 Viemari J.C....Hilaire G. (J. Neurosci. 2005)
    623. Early onset seizures and Rett-like features associated with mutations in CDKL5. (PubMed id 16015284)9 Evans J.C.... Clarke A.J. (Eur. J. Hum. Genet. 2005)
    624. Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation. (PubMed id 15939760)9 Brero A....Cardoso M.C. (J. Cell Biol. 2005)
    625. Another patient with MECP2 mutation without classic Rett syndrome phenotype. (PubMed id 15866439)9 Milani D....Riva D. (Pediatr. Neurol. 2005)
    626. Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. (PubMed id 16254496)9 Paterson D.S....Kinney H.C. (J. Neuropathol. Exp. Neurol. 2005)
    627. Specific genetic disorders and autism: clinical contribution towards their identification. (PubMed id 15796126)9 Cohen D....HAcron D. (J Autism Dev Disord 2005)
    628. 5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2). (PubMed id 15917437)9 Valinluck V....Sowers L.C. (Nucleic Acids Res. 2005)
    629. Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. (PubMed id 15870696)9 Reid G....Gannon F. (Oncogene 2005)
    630. Mutation analysis of the HDAC 1, 2, 8 and CDKL5 genes in Rett syndrome patients without mutations in MECP2. (PubMed id 16086395)9 Huppke P....GAortner J. (Am. J. Med. Genet. A 2005)
    631. CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms. (PubMed id 15689447)9 Scala E....Renieri A. (J. Med. Genet. 2005)
    632. Structural basis for APPTPPPLPP peptide recognition by the FBP11WW1 domain. (PubMed id 15811376)9 Pires J.R....Oschkinat H. (J. Mol. Biol. 2005)
    633. A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth. (PubMed id 15939091)9 Nagai K....Kubota T. (Brain Res. Dev. Brain Res. 2005)
    634. Mutation analysis of methyl-CpG binding protein family genes in autistic patients. (PubMed id 15967618)9 Li H....Momoi M.Y. (amp 2005)
    635. Rett syndrome: model of neurodevelopmental disorders. (PubMed id 16225824)9 Percy A.K. and Lane J.B. (J. Child Neurol. 2005)
    636. The transcriptional repressor Mecp2 regulates terminal neuronal differentiation. (PubMed id 15345242)9 Matarazzo V....Ronnett G.V. (Mol. Cell. Neurosci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4204 HGNC: 6990 AceView: MECP2 Ensembl:ENSG00000169057 euGenes: HUgn4204
    ECgene: MECP2 H-InvDB: MECP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MECP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MECP2 Genetics and Cytogenetics in Oncology and Haematology
    RettBASEhttp://mecp2.chw.edu.au/mecp2/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MECP2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MECP2 gene:
    Search GeneIP for patents involving MECP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MECP2
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MECP2   OriGene RNAi products in human, mouse, rat for MECP2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MECP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MECP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MECP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MECP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MECP2   OriGene Custom Protein Services for MECP2  

     
     
     Block miRNA regulation of human, mouse, rat MECP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MECP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MECP2 Predesigned siRNA for gene silencing in human, mouse, rat MECP2
     QuantiFast Probe-based Assays in human, mouse, rat MECP2 QuantiTect SYBR Green Assays in human, mouse, rat MECP2
     PCR Arrays including human, mouse, rat MECP2 Search Chromatin IP Primers for MECP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MECP2  GeneGlobe Interaction Network for MECP2
     Regulatory tfbs in MECP2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MECP2 GenScript cDNA clones with any tag delivered in your preferred vector for MECP2
     GenScript Custom Assay Services for MECP2 GenScript Custom overexpressing Cell Line Services for MECP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MECP2 

     Search Tocris compounds for MECP2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MECP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MECP2 antibodies
     MECP2 proteins
     MECP2 lysates
     Antibodies for MECP2
     See all of Abcam's Antibodies, Kits and Proteins for MECP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MECP2
     Proteins for MECP2
     Antibodies for MECP2
     ELISAs for MECP2
     CLIAs for MECP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for MECP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECP2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MECP2
     SwitchGear Promoter luciferase reporter plasmids for MECP2
     ThermoFisher Antibody for MECP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECP2
     Browse compounds at ApexBio
     Addgene plasmids for MECP2
      Search eBioscience for proteins for MECP2
      Search eBioscience for elisas for MECP2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MECP2
     antibodies-online antibodies for MECP2 (118 products)
     antibodies-online kits for MECP2 (9 products)
     antibodies-online peptides for MECP2
     antibodies-online proteins for MECP2 (11 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MECP2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4