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Aliases for MECOM Gene

Aliases for MECOM Gene

  • MDS1 And EVI1 Complex Locus 2 3
  • EVI1 3 4 6
  • Ecotropic Virus Integration Site 1 Protein Homolog 3 4
  • Myelodysplasia Syndrome-Associated Protein 1 3 4
  • MDS1 3 4
  • MDS1 And EVI1 Complex Locus Protein EVI1 3
  • MDS1 And EVI1 Complex Locus Protein MDS1 3
  • Ecotropic Viral Integration Site 1 2
  • Myelodysplasia Syndrome 1 Protein 4
  • Myelodysplasia Syndrome 1 2
  • AML1-EVI-1 Fusion Protein 3
  • Zinc Finger Protein Evi1 3
  • Oncogene EVI1 3
  • AML1-EVI-1 3
  • MDS1-EVI1 3
  • PRDM3 3
  • EVI-1 4

External Ids for MECOM Gene

Previous HGNC Symbols for MECOM Gene

  • MDS1
  • EVI1

Previous GeneCards Identifiers for MECOM Gene

  • GC03M170284
  • GC03M168802
  • GC03M166172

Summaries for MECOM Gene

Entrez Gene Summary for MECOM Gene

  • The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for MECOM Gene

MECOM (MDS1 And EVI1 Complex Locus) is a Protein Coding gene. Diseases associated with MECOM include 'acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)' and denys-drash syndrome. Among its related pathways are MAPK signaling pathway and Pathways in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is PRDM16.

UniProtKB/Swiss-Prot for MECOM Gene

  • Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.

Gene Wiki entry for MECOM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MECOM Gene

Genomics for MECOM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MECOM Gene

Start:
169,083,499 bp from pter
End:
169,663,775 bp from pter
Size:
580,277 bases
Orientation:
Minus strand

Genomic View for MECOM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MECOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MECOM Gene

No data available for Regulatory Elements for MECOM Gene

Proteins for MECOM Gene

  • Protein details for MECOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03112-EVI1_HUMAN
    Recommended name:
    MDS1 and EVI1 complex locus protein EVI1
    Protein Accession:
    Q03112
    Secondary Accessions:
    • A1L4F3
    • A8KA00
    • B7Z8W7
    • B7ZLQ3
    • B7ZLQ4
    • C9JAK0
    • D3DNP7
    • Q16122
    • Q5HYI1
    • Q6MZS6
    • Q8NEI5
    • Q99917

    Protein attributes for MECOM Gene

    Size:
    1051 amino acids
    Molecular mass:
    118276 Da
    Quaternary structure:
    • Homooligomer. Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity (By similarity). Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct. Interacts with SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases. Interacts with MAPK8 and MAPK9; inhibits JNK signaling.
    SequenceCaution:
    • Sequence=AAB29907.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB37456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI30521.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAH14103.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for MECOM Gene

  • Protein details for MECOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13465-MDS1_HUMAN
    Recommended name:
    MDS1 and EVI1 complex locus protein MDS1
    Protein Accession:
    Q13465
    Secondary Accessions:
    • Q13466
    • Q6FH90

    Protein attributes for MECOM Gene

    Size:
    169 amino acids
    Molecular mass:
    18696 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MECOM Gene

neXtProt entry for MECOM Gene

Proteomics data for MECOM Gene at MOPED

Post-translational modifications for MECOM Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MECOM (EVI1)

No data available for DME Specific Peptides for MECOM Gene

Domains for MECOM Gene

Gene Families for MECOM Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for MECOM Gene

Suggested Antigen Peptide Sequences for MECOM Gene

Graphical View of Domain Structure for InterPro Entry

Q03112

UniProtKB/Swiss-Prot:

MDS1_HUMAN :
  • Q03112
Domain:
  • Both zinc finger regions are required for the transcriptional activation of PBX1
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MECOM: view

Function for MECOM Gene

Molecular function for MECOM Gene

UniProtKB/Swiss-Prot Function: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.

Gene Ontology (GO) - Molecular Function for MECOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8643684
GO:0005515 protein binding IPI 10856240
GO:0042803 NOT protein homodimerization activity IDA 15897867
genes like me logo Genes that share ontologies with MECOM: view
genes like me logo Genes that share phenotypes with MECOM: view

Animal Models for MECOM Gene

MGI Knock Outs for MECOM:

Animal Model Products

CRISPR Products

Transcription Factor Targeting for MECOM Gene

Selected GeneGlobe predicted Target genes for MECOM

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MECOM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA and HOMER Transcription for MECOM Gene

Localization for MECOM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MECOM Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MECOM Gene COMPARTMENTS Subcellular localization image for MECOM gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MECOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 11568182
GO:0005634 nucleus IDA 15897867
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with MECOM: view

Pathways for MECOM Gene

genes like me logo Genes that share pathways with MECOM: view

Pathways by source for MECOM Gene

1 Cell Signaling Technology pathway for MECOM Gene
1 GeneGo (Thomson Reuters) pathway for MECOM Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MECOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001780 neutrophil homeostasis IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 8643684
genes like me logo Genes that share ontologies with MECOM: view

Compounds for MECOM Gene

(1) Novoseek inferred chemical compound relationships for MECOM Gene

Compound -log(P) Hits PubMed IDs
zinc 36.2 3
genes like me logo Genes that share compounds with MECOM: view

Transcripts for MECOM Gene

Unigene Clusters for MECOM Gene

MDS1 and EVI1 complex locus:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MECOM

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MECOM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MECOM Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - -
SP9: -
SP10:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MECOM Gene

GeneLoc Exon Structure for
MECOM
ECgene alternative splicing isoforms for
MECOM

Expression for MECOM Gene

mRNA expression in normal human tissues for MECOM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MECOM Gene

This gene is overexpressed in Stomach (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MECOM Gene

SOURCE GeneReport for Unigene cluster for MECOM Gene Hs.744090

genes like me logo Genes that share expressions with MECOM: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MECOM Gene

Orthologs for MECOM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MECOM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MECOM 35
  • 99.76 (n)
  • 99.91 (a)
MECOM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MECOM 35
  • 94.19 (n)
  • 96.85 (a)
MECOM 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MECOM 35
  • 95.4 (n)
  • 97.44 (a)
MECOM 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mecom 35
  • 88.29 (n)
  • 92.36 (a)
Mecom 16
Mecom 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MECOM 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MECOM 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves MECOM 35
  • 84.92 (n)
  • 89.91 (a)
MECOM 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MECOM 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496511 35
  • 74.78 (n)
  • 77.18 (a)
Str.12493 35
zebrafish
(Danio rerio)
Actinopterygii mecom 35
  • 65.52 (n)
  • 69.28 (a)
mecom 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ham 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-43 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSN2 36
  • 17 (a)
ManyToMany
MSN4 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.322 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MECOM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MECOM Gene

ENSEMBL:
Gene Tree for MECOM (if available)
TreeFam:
Gene Tree for MECOM (if available)

Paralogs for MECOM Gene

Paralogs for MECOM Gene

genes like me logo Genes that share paralogs with MECOM: view

Variants for MECOM Gene

Sequence variations from dbSNP and Humsavar for MECOM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs15214 -- 169,499,307(+) AGAGA(A/G)AAATC intron-variant
rs170334 -- 169,327,570(+) gaggc(A/G)gaggt intron-variant
rs170335 -- 169,384,295(-) CTACA(A/G)GTTTA intron-variant
rs172761 -- 169,348,284(+) AAGAG(A/G)CTGTT intron-variant
rs223101 -- 169,322,073(+) GCACC(C/T)CTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MECOM Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
esv272132 CNV Insertion 20981092
esv272478 CNV Insertion 20981092
esv2726180 CNV Deletion 23290073
esv2726181 CNV Deletion 23290073
esv2726182 CNV Deletion 23290073
esv2594592 CNV Deletion 19546169
nsv877975 CNV Gain 21882294
nsv528819 CNV Loss 19592680
nsv4108 CNV Insertion 18451855
nsv829791 CNV Loss 17160897
nsv829792 CNV Loss 17160897
esv271921 CNV Insertion 20981092
esv2726183 CNV Deletion 23290073
esv2726184 CNV Deletion 23290073
esv2726186 CNV Deletion 23290073
nsv508965 CNV Insertion 20534489
nsv4109 CNV Insertion 18451855
esv2844 CNV Deletion 18987735
esv7580 CNV Loss 19470904
esv2674789 CNV Deletion 23128226
esv2726187 CNV Deletion 23290073
esv268746 CNV Insertion 20981092
nsv4111 CNV Loss 18451855
esv275118 CNV Loss 21479260
esv24422 CNV Gain 19812545
esv2422204 CNV Deletion 17116639
esv2676634 CNV Deletion 23128226

Relevant External Links for MECOM Gene

HapMap Linkage Disequilibrium report
MECOM
Human Gene Mutation Database (HGMD)
MECOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MECOM Gene

Disorders for MECOM Gene

UniProtKB/Swiss-Prot

MDS1_HUMAN
  • Note=A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1.
  • Note=A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.

(4) University of Copenhagen DISEASES for MECOM Gene

(16) Novoseek inferred disease relationships for MECOM Gene

Disease -log(P) Hits PubMed IDs
myelodysplastic syndromes 69.4 8
myeloid leukemia 69.2 6
leukemogenesis 67.7 2
leukemia 59.9 20
blast crisis 59.2 3

Relevant External Links for MECOM

Genetic Association Database (GAD)
MECOM
Human Genome Epidemiology (HuGE) Navigator
MECOM
genes like me logo Genes that share disorders with MECOM: view

Publications for MECOM Gene

  1. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. (PMID: 8643684) Fears S. … Nucifora G. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  2. EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. (PMID: 11922610) Shimizu S. … Morishita K. (Biochem. Biophys. Res. Commun. 2002) 3 23
  3. A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. (PMID: 18619962) Spensberger D. … Delwel R. (FEBS Lett. 2008) 3 23
  4. Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. (PMID: 19605700) Konrad T.A. … Wieser R. (J. Leukoc. Biol. 2009) 3 23
  5. EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization. (PMID: 19776757) Goyama S. … Kurokawa M. (Leukemia 2010) 3 23

Products for MECOM Gene

  • Addgene plasmids for MECOM

Sources for MECOM Gene

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