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MECOM Gene

protein-coding   GIFtS: 56
GCID: GC03M168802

MDS1 And EVI1 Complex Locus

(Previous names: myelodysplasia syndrome 1, ecotropic viral integration site...)
(Previous symbols: MDS1, EVI1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MDS1 And EVI1 Complex Locus1 2     PRDM32
EVI11 2 3 5     AML1-EVI-1 Fusion Protein2
MDS11 2 3     MDS1 And EVI1 Complex Locus Protein EVI12
Ecotropic Virus Integration Site 1 Protein Homolog2 3     MDS1 And EVI1 Complex Locus Protein MDS12
Myelodysplasia Syndrome-Associated Protein 12 3     Oncogene EVI12
Ecotropic Viral Integration Site 11     Zinc Finger Protein Evi12
Myelodysplasia Syndrome 11     EVI-13
AML1-EVI-12     Myelodysplasia Syndrome 1 Protein3
MDS1-EVI12     

External Ids:    HGNC: 34981   Entrez Gene: 21222   Ensembl: ENSG000000852767   OMIM: 1652155   UniProtKB: Q031123   
UniProtKB: Q134653   

Export aliases for MECOM gene to outside databases

Previous GC identifers: GC03M170284 GC03M166172


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MECOM Gene:
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in
hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can
interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1
gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a
few different isoforms have been found for this gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for MECOM Gene:
MECOM (MDS1 and EVI1 complex locus) is a protein-coding gene. Diseases associated with MECOM include 3q21q26 syndrome, and myelodysplasia syndrome-1. GO annotations related to this gene include protein homodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PRDM13.

UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112
Function: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes
and regulating positively or negatively their expression. Oncogene which plays a role in development, cell
proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta
signaling. Involved in hematopoiesis

Gene Wiki entry for MECOM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MECOM
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMECOM promoter sequence
   Search Chromatin IP Primers for MECOM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MECOM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2

MECOM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MECOM gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M168802:  view genomic region     (about GC identifiers)

Start:
168,801,287 bp from pter      End:
169,381,563 bp from pter
Size:
580,277 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112 (See protein sequence)
Recommended Name: MDS1 and EVI1 complex locus protein EVI1  
Size: 1051 amino acids; 118276 Da
Subunit: Homooligomer. Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity
(By similarity). Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct.
Interacts with SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases.
Interacts with MAPK8 and MAPK9; inhibits JNK signaling
Sequence caution: Sequence=AAB29907.1; Type=Erroneous initiation; Sequence=AAB37456.1; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=AAI30521.1; Type=Erroneous initiation; Sequence=BAH14103.1;
Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: A1L4F3 A8KA00 B7Z8W7 B7ZLQ3 B7ZLQ4 C9JAK0 D3DNP7 Q16122 Q5HYI1 Q6MZS6
Q8NEI5 Q99917
Alternative promoter usage, Alternative splicing: 6 isoforms:  Q03112-1   Q03112-3   Q13465-1   Q03112-4   Q03112-5   Q03112-6   (Produced by alternative promoter usage)

UniProtKB/Swiss-Prot: MDS1_HUMAN, Q13465 (See protein sequence)

Recommended Name: MDS1 and EVI1 complex locus protein MDS1  
Size: 169 amino acids; 18696 Da
Secondary accessions: Q13466 Q6FH90
Alternative promoter usage, Alternative splicing: 6 isoforms:  Q13465-1   Q03112-1   Q03112-3   Q03112-4   Q03112-5   Q03112-6   (Produced by alternative promoter usage. Contains an additional SET domain at positions 79-194. Unable to form homooligomers, to interact with CTBP1 and SMAD3 and to repress TGF-beta signaling)

Explore the universe of human proteins at neXtProt for MECOM: NX_Q13465

Explore proteomics data for MECOM at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • May be acetylated by CREBBP and KAT2B1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus (EVI1)

  • See MECOM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001098547.3  NP_001098548.2  NP_001157471.1  NP_001157472.1  NP_001192123.1  NP_004982.2  NP_005232.2  

    ENSEMBL proteins: 
     ENSP00000419770   ENSP00000420048   ENSP00000417899   ENSP00000419995   ENSP00000420466  
     ENSP00000394302   ENSP00000417506   ENSP00000417299   ENSP00000417922   ENSP00000419757  
     ENSP00000420072   ENSP00000418828   ENSP00000418046   ENSP00000418689   ENSP00000419537  
     ENSP00000264674   ENSP00000376493  

    MECOM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MECOM
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MECOM
    GenScript Custom Purified and Recombinant Proteins Services for MECOM
    Novus Biologicals MECOM Proteins
    Novus Biologicals MECOM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MECOM Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MECOM (EVI-1)
    Cell Signaling Technology (CST) Antibodies for MECOM  (EVI1)
    OriGene Antibodies for MECOM
    OriGene Custom Antibody Services for MECOM
    Novus Biologicals MECOM Antibodies
    Abcam antibodies for MECOM (Q03112, Q13465)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MECOM
    LSBio Antibodies in human, mouse, rat for MECOM

    MECOM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MECOM
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MECOM
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR026710 MDS1
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q03112
    Graphical View of Domain Structure for InterPro Entry Q13465

    ProtoNet protein and cluster: Q03112

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112
    Domain: Both zinc finger regions are required for the transcriptional activation of PBX1
    Similarity: Contains 10 C2H2-type zinc fingers


    MECOM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EVI1_HUMAN, Q03112
    Function: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes
    and regulating positively or negatively their expression. Oncogene which plays a role in development, cell
    proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta
    signaling. Involved in hematopoiesis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8643684
    GO:0005515protein binding IPI10856240
    GO:0042803NOT protein homodimerization activity IDA15897867
         
    MECOM for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Mecom) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     embryogenesis  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    MECOM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MECOM: Mecomtm1Mmor Mecomtm1.1Miku

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MECOM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MECOM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MECOM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MECOM

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for MECOM (see all 1397):
    AAA1,  ABCA5,  ABCD2,  ABCG5,  ABCG8,  ABI3BP,  ABT1,  ACAD8,  ACBD3,  ACBD7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MECOM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MECOM (see all 64):
    hsa-miR-3678-3p hsa-miR-4291 hsa-miR-100* hsa-miR-4328 hsa-miR-548k hsa-miR-16-1* hsa-let-7a-2* hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidMECOM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MECOM
    Predesigned siRNA for gene silencing in human, mouse, rat MECOM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MECOM

    Clone
    Products:
         
    OriGene clones in human, mouse for MECOM (see all 41)
    OriGene ORF clones in mouse, rat for MECOM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): MECOM (NM_005241)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MECOM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECOM

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MECOM
    Browse ESI BIO Cell Lines and PureStem Progenitors for MECOM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECOM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EVI1_HUMAN, Q03112: Nucleus. Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118colocalizes with histone deacetylase complex IDA11568182
    GO:0005634nucleus IDA15897867
    GO:0016607nuclear speck IDA11568182

    MECOM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MECOM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    2Chronic myeloid leukemia
    Chronic myeloid leukemia0.42
    3Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40
    4Pathways in cancer
    Pathways in cancer
    5Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MECOM
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for MECOM
        Signal transduction Activin A signaling regulation


    3 Kegg Pathways  (Kegg details for MECOM):
        MAPK signaling pathway
    Pathways in cancer
    Chronic myeloid leukemia


    MECOM for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MECOM: 
              TGFB/BMP Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MECOM

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for MECOM (Q031121 Q134651, 3 ENSP000002646744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT1Q96EB61EBI-1384862,EBI-1802965
    UXTQ9UBK91EBI-1384862,EBI-357355
    Ctbp2P565461EBI-1384862,EBI-1384883
    --ensp: ENSP000004178994STRING: ensp: ENSP00000417899
    --uniprotid: Q031123I2D: score= 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001780neutrophil homeostasis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS8643684
    GO:0006915apoptotic process IEA--

    MECOM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MECOM (MDS1)

    1 Novoseek inferred chemical compound relationship for MECOM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 36.2 3 10867128 (2), 8921366 (1)



    MECOM for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MECOM gene (7 alternative transcripts): 
    NM_001105077.3  NM_001105078.3  NM_001163999.1  NM_001164000.1  NM_001205194.1  NM_004991.3  NM_005241.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000464456(uc003ffk.2) ENST00000472280 ENST00000494292(uc010hwn.2)
    ENST00000468789 ENST00000460814 ENST00000433243 ENST00000492586 ENST00000461430
    ENST00000484519 ENST00000460890(uc003ffm.1) ENST00000487503 ENST00000494597
    ENST00000475754 ENST00000481315 ENST00000466623 ENST00000485957(uc011bpl.1)
    ENST00000486748 ENST00000264674(uc003ffj.3 uc011bpi.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MECOM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MECOM (see all 64):
    hsa-miR-3678-3p hsa-miR-4291 hsa-miR-100* hsa-miR-4328 hsa-miR-548k hsa-miR-16-1* hsa-let-7a-2* hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidMECOM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MECOM
    Predesigned siRNA for gene silencing in human, mouse, rat MECOM
    Clone
    Products:
         
    OriGene clones in human, mouse for MECOM (see all 41)
    OriGene ORF clones in mouse, rat for MECOM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): MECOM (NM_005241)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MECOM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECOM
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MECOM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MECOM
      QuantiTect SYBR Green Assays in human, mouse, rat MECOM
      QuantiFast Probe-based Assays in human, mouse, rat MECOM

    Selected AceView cDNA sequences (see all 120):

    AA961157 BQ102518 BC031019 AF487422 AA335418 AA335020 AA913663 CB132738 
    BM768941 AA236533 AA335780 AL699361 AI808322 BC012450 AI587511 BX647613 
    AW851143 BX482681 AI079954 BM788887 BX280183 AA132806 BU741968 AL697689 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MECOM (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                      -           -     -                                                                                                   
    SP2:                                                                                                                                            -               
    SP3:                                                        -                                                                                                   
    SP4:        -     -     -     -     -     -           -     -                                                                                                   
    SP5:                    -     -     -     -           -     -                                                                                                   

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MECOM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MECOM expression in normal human tissues (normalized intensities)      MECOM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MECOM Expression
    About this image


    MECOM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
             mK3
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Periosteum
             Bone marrow-derived mesenchymal stem cells
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
    MECOM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MECOM Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including MECOM: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MECOM gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mecom1 , 5 MDS1 and EVI1 complex locus1, 5 88.29(n)1
    92.36(a)1
      3 (12.66 cM)5
    140131  NM_007963.21  NP_031989.21 
     299512995 
    chicken
    (Gallus gallus)
    Aves MECOM1 MDS1 and EVI1 complex locus 84.92(n)
    89.91(a)
      424997  XM_004943500.1  XP_004943557.1 
    lizard
    (Anolis carolinensis)
    Reptilia MECOM6
    MDS1 and EVI1 complex locus
    86(a)
    1 ↔ 1
    3(8521985-8599306)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.124932 Transcribed sequence with moderate similarity to protein more 78.77(n)    BX713731.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mecom1 MDS1 and EVI1 complex locus 65.52(n)
    69.28(a)
      497407  XM_001920912.4  XP_001920947.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta ham6
    hamlet
    27(a)
    1 → many
    2L(18762874-18792906)
    worm
    (Caenorhabditis elegans)
    Secernentea egl-436
    Protein EGL-43, isoform a (egl-43) mRNA, complete ...
    30(a)
    1 → many
    II(9955186-9962244) WBGene00001207
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSN26
    MSN46
    Transcriptional activator related to Msn4p; activa...
    Transcriptional activator related to Msn2p; activa...
    17(a)
    16(a)
    many ↔ many
    many ↔ many
    XIII(344403-346517) YMR037C
    XI(323228-325120) YKL062W


    ENSEMBL Gene Tree for MECOM (if available)
    TreeFam Gene Tree for MECOM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MECOM gene
    PRDM132  PRDM162  
    Selected SIMAP similar genes for MECOM using alignment to 10 protein entries:     EVI1_HUMAN (see all proteins) (see all similar genes):
    EVI1    ZFS-5    ZIC1    ZFS-4    kr-znf3    DKFZp686N0199
    ZNF55    PRDM16    zf30    KLF1    ZNF78L1    ZNF
    DKFZp686M04222    ZNF56    ZFS-2    ZNF72    ZNF22    DKFZp547H249

    MECOM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MECOM (see all 11660)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49556361,2
    C,A,H--166185528(+) GCCCCG/AGTTTT 7 -- int19Minor allele frequency- A:0.00EA NS NA WA CSA 263
    rs674199281,2
    C--166185528(+) GCCCC-/AGTTTT 7 -- int10--------
    rs2016697191,2
    C--166188657(+) TTTCT-/TCCTTTT 7 -- int10--------
    rs114052021,2
    C--166190134(+) AAAAAA/-TCACA 7 -- int11Minor allele frequency- -:0.00NA 2
    rs106628331,2
    C--166202016(+) tatTC-/AGAGAGA 7 -- int1 trp30--------
    rs607018581,2
    C--166213118(+) TAATA-/TTAAGAAA 7 -- int11Minor allele frequency- TTA:0.00NA 2
    rs114412071,2
    C--166217977(+) ATTTTC/-CCCAG 7 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs567073991,2
    C--166228627(+) TAATG-/AAAAAA 7 -- int10--------
    rs720432391,2
    C--166229310(+) TTTAA-/ACTACTCA 7 -- int10--------
    rs113121671,2
    C--166232829(+) CTAAAT/-TTTTT 7 -- int1 trp31Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for MECOM (168801287 - 169051287 bp, first 250kb of MECOM)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MECOM (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726184CNV Deletion23290073
    esv2726183CNV Deletion23290073
    esv2726182CNV Deletion23290073
    esv2726186CNV Deletion23290073
    esv2674789CNV Deletion23128226
    esv2844CNV Deletion18987735
    esv2676634CNV Deletion23128226
    esv2726187CNV Deletion23290073
    esv2726181CNV Deletion23290073
    esv2422204CNV Deletion17116639

    Human Gene Mutation Database (HGMD): MECOM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MECOM
    DNA2.0 Custom Variant and Variant Library Synthesis for MECOM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165215    OMIM disorders: --

    UniProtKB/Swiss-Prot: MDS1_HUMAN, Q13465
  • Note=A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML).
    Translocation t(3;21)(q26;q22) with RUNX1/AML1
  • Note=A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML).
    Translocation t(3;21) with AML1

  • Selected diseases for MECOM (see all 43):    About MalaCards
    3q21q26 syndrome    myelodysplasia syndrome-1    myelodysplastic syndrome, somatic    frasier syndrome
    denys-drash syndrome    borjeson-forssman-lehmann syndrome    mn1    pallister-hall syndrome
    acute myelomonocytic leukemia    goldenhar syndrome    osteoporotic fracture    chronic granulomatous disease
    thrombocytosis    diabetes insipidus    nephroblastoma    myeloid leukemia
    myelodysplastic syndromes    leukemia    smallpox    acute myeloid leukemia

    4 diseases from the University of Copenhagen DISEASES database for MECOM:
    Nephroblastoma     Pallister-Hall syndrome     Leukemia     Denys-Drash syndrome

    MECOM for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MECOM gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myelodysplastic syndromes 69.4 11 11243114 (2), 11721451 (2), 8700545 (1), 17409414 (1) (see all 6)
    myeloid leukemia 69.2 6 8700545 (1), 17913523 (1), 10867128 (1), 12972028 (1) (see all 6)
    leukemogenesis 67.7 2 12972028 (1), 16014322 (1)
    leukemia 59.9 22 9183665 (4), 7808006 (2), 10867128 (2), 16156860 (1) (see all 15)
    blast crisis 59.2 3 18613965 (2), 7808006 (1)
    hematopoietic malignancies 58.5 1 11069022 (1)
    monosomy 46.9 5 20098431 (3), 12139729 (1)
    myeloid leukemia chronic 41.8 3 7808006 (2)
    chromosomal aberrations 32.6 4 8700545 (1), 18619962 (1), 14704036 (1), 17243162 (1)
    minimal residual disease 31.3 2 11248334 (1), 17693194 (1)

    Genetic Association Database (GAD): MECOM
    Human Genome Epidemiology (HuGE) Navigator: MECOM (3 documents)

    Export disorders for MECOM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MECOM gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with MECOM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. (PubMed id 8643684)1, 2, 3 Fears S....Nucifora G. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (Nature 2011)
    3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    4. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. (PubMed id 20512145)1, 4 Bei J.X....Zeng Y.X. (Nat. Genet. 2010)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PubMed id 20700443)1, 4 Meyer T.E.... . (PLoS Genet. 2010)
    9. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)
    10. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)1, 4 Levy D....van Duijn C.M. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2122 HGNC: 3498 AceView: EVI1 Ensembl:ENSG00000085276 euGenes: HUgn2122
    ECgene: MECOM Kegg: 2122 H-InvDB: MECOM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MECOM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MECOM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MECOM gene:
    Search GeneIP for patents involving MECOM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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