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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MECOM Gene

protein-coding GIFtS: 60
GCID: GC03M168802

MDS1 and EVI1 complex locus

(Previous names: myelodysplasia syndrome 1, ecotropic viral integration...)
(Previous symbols: MDS1, EVI1)

Explore 34 diseases affiliated with
MECOM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MDS1 And EVI1 Complex Locus¹ ²		AML1-EVI-1²
EVI1¹ ² ³ ⁵		AML1-EVI-1 Fusion Protein²
MDS1¹ ² ³		MDS1 And EVI1 Complex Locus Protein EVI1²
MDS1-EVI1¹ ²		MDS1 And EVI1 Complex Locus Protein MDS1²
PRDM3¹ ²		Oncogene EVI1²
Ecotropic Virus Integration Site 1 Protein Homolog² ³		Zinc Finger Protein Evi1²
Myelodysplasia Syndrome-Associated Protein 1² ³		EVI-1³
Ecotropic Viral Integration Site 1¹		Myelodysplasia Syndrome 1 Protein³
Myelodysplasia Syndrome 1¹

External Ids:	HGNC: 3498¹	Entrez Gene: 2122²	Ensembl: ENSG00000085276⁷	OMIM: 165215⁵	UniProtKB: Q03112³
	UniProtKB: Q13465³

Export aliases for MECOM gene to outside databases

Previous GC identifers: GC03M170284 GC03M166172

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MECOM:

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis,

apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1,

SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in

overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms

have been found for this gene. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112

Function: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and

regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation

and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved

in hematopoiesis

Gene Wiki entry for MECOM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MECOM
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MECOM promoter sequence

Search SABiosciences Chromatin IP Primers for MECOM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MECOM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2 Ensembl cytogenetic band: 3q26.2 HGNC cytogenetic band: 3q26.2

MECOM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MECOM gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M168802: view genomic region (about GC identifiers)

Start:	168,801,287 bp from pter	End:	169,381,563 bp from pter
Size:	580,277 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112 (See protein sequence)

Recommended Name: MDS1 and EVI1 complex locus protein EVI1

Size: 1051 amino acids; 118276 Da

Subunit: Homooligomer. Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity (By

similarity). Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct. Interacts with

SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases. Interacts with MAPK8 and

MAPK9; inhibits JNK signaling

Subcellular location: Nucleus. Nucleus speckle

Sequence caution: Sequence=AAB29907.1; Type=Erroneous initiation; Sequence=AAB37456.1; Type=Miscellaneous discrepancy;

Note=Probable cloning artifact; Sequence=AAI30521.1; Type=Erroneous initiation; Sequence=BAH14103.1;

Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Secondary accessions: A1L4F3 A8KA00 B7Z8W7 B7ZLQ3 B7ZLQ4 C9JAK0 D3DNP7 Q16122 Q5HYI1 Q6MZS6 Q8NEI5

Q99917

Alternative promoter usage, Alternative splicing: 6 isoforms: Q03112-1 Q03112-3 Q13465-1 Q03112-4 Q03112-5 Q03112-6 (Produced by alternative promoter usage)

UniProtKB/Swiss-Prot: MDS1_HUMAN, Q13465 (See protein sequence)

Recommended Name: MDS1 and EVI1 complex locus protein MDS1

Size: 169 amino acids; 18696 Da

Secondary accessions: Q13466 Q6FH90

Alternative promoter usage, Alternative splicing: 6 isoforms: Q13465-1 Q03112-1 Q03112-3 Q03112-4 Q03112-5 Q03112-6 (Produced by alternative promoter usage. Contains an additional SET domain at positions 79-194. Unable to form homooligomers, to interact with CTBP1 and SMAD3 and to repress TGF-beta signaling)

Explore the universe of human proteins at neXtProt for MECOM: NX_Q13465

Post-translational modifications:

Phosphorylated (By similarity)¹

May be acetylated by CREBBP and KAT2B¹

View modification sites using PhosphoSitePlus² (MDS1)

View neXtProt modification sites for NX_Q13465

MECOM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001098547.3 NP_001098548.2 NP_001157471.1 NP_001157472.1 NP_001192123.1 NP_004982.2 NP_005232.2

ENSEMBL proteins:

ENSP00000419770 ENSP00000420048 ENSP00000417899 ENSP00000419995 ENSP00000420466

ENSP00000394302 ENSP00000417506 ENSP00000417299 ENSP00000417922 ENSP00000419757

ENSP00000420072 ENSP00000418828 ENSP00000418046 ENSP00000418689 ENSP00000419537

ENSP00000264674 ENSP00000376493

Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for MECOM
	Novus Biologicals MECOM Proteins Novus Biologicals MECOM Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MECOM

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000118	colocalizes with histone deacetylase complex	IDA	11568182
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	15897867
GO:0016607	nuclear speck	IDA	11568182

MECOM for ontologies About GeneDecksing

MECOM Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for MECOM (EVI-1)
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	OriGene Antibodies: MECOM OriGene Custom Antibody Services for MECOM
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	Novus Biologicals MECOM Antibodies
	Abcam antibodies for MECOM
	Uscn Antibodies for MECOM
	ThermoFisher Antibodies for MECOM

Assay Products for MECOM:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MECOM
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MECOM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MECOM for domains About GeneDecksing

4 InterPro domains/families:

IPR026710 MDS1

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q03112

Graphical View of Domain Structure for InterPro Entry Q13465

ProtoNet protein and cluster: Q03112

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112

Domain: Both zinc finger regions are required for the transcriptional activation of PBX1

Similarity: Contains 10 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112

Function: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and

regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation

and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved

in hematopoiesis

miRNA Products:		OriGene 3'-UTR Clone (see all 6): MECOM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MECOM
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate MECOM (see all 64):
		hsa-miR-3678-3p hsa-miR-4291 hsa-miR-100* hsa-miR-4328 hsa-miR-548k hsa-miR-16-1* hsa-let-7a-2* hsa-miR-219-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MECOM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MECOM (see all 4) OriGene shRNA RFP: MECOM OriGene siRNA: MECOM
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MECOM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 7): MECOM (NM_005241)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECOM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MECOM
		Search LifeMap BioReagents cell lines for MECOM

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECOM

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	ISS	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8643684
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--

MECOM for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for MECOM: Mecom^tm1Mmor Mecom^tm1.1Miku
     15/22 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Mecom) (see all 22):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
embryogenesis	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle

MECOM for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal transduction Activin A signaling regulation

Signal transduction Activin A signaling regulation

1.00

Signal transduction_Activin A signaling regulation

0.96

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Chronic myeloid leukemia

Chronic myeloid leukemia

1.00

Pathways in cancer

Pathways in cancer

1.00

MAPK signaling pathway

MAPK signaling pathway

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MECOM

Signal transduction Activin A signaling regulation

1 Cell Signaling Technology (CST) Pathway for MECOM

Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for MECOM

Signal transduction Activin A signaling regulation

3 Kegg Pathways (Kegg details for MECOM):

	MAPK signaling pathway
	Pathways in cancer
	Chronic myeloid leukemia

MECOM for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MECOM

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5 Interacting proteins for MECOM (Q03112¹ Q13465^{1, 3} ENSP00000264674⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIRT1	Q96EB6¹	EBI-1384862,EBI-1802965
UXT	Q9UBK9¹	EBI-1384862,EBI-357355
Ctbp2	P56546¹	EBI-1384862,EBI-1384883
--	ensp: ENSP00000417899⁴	STRING: ensp: ENSP00000417899
--	uniprotid: Q03112³	I2D: score=

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001780	neutrophil homeostasis	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	8643684
GO:0006915	apoptotic process	IEA	--

MECOM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MECOM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MECOM
1 Novoseek chemical compound relationship for MECOM gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	36.2	3	10867128 (2), 8921366 (1)

Search CenterWatch for drugs/clinical trials and news about MECOM / MDS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MECOM gene (7 alternative transcripts):

NM_001105077.3 NM_001105078.3 NM_001163999.1 NM_001164000.1 NM_001205194.1 NM_004991.3 NM_005241.3

Unigene Cluster for MECOM:

MDS1 and EVI1 complex locus

Hs.744090 [show with all ESTs]

Unigene Representative Sequence: BX640908

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000464456(uc003ffk.2) ENST00000472280 ENST00000494292(uc010hwn.2)

ENST00000468789 ENST00000460814 ENST00000433243 ENST00000492586 ENST00000461430

ENST00000484519 ENST00000460890(uc003ffm.1) ENST00000487503 ENST00000494597

ENST00000475754 ENST00000481315 ENST00000466623 ENST00000485957(uc011bpl.1)

ENST00000486748 ENST00000264674(uc003ffj.3 uc011bpi.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 6): MECOM Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MECOM
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate MECOM (see all 64):
		hsa-miR-3678-3p hsa-miR-4291 hsa-miR-100* hsa-miR-4328 hsa-miR-548k hsa-miR-16-1* hsa-let-7a-2* hsa-miR-219-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MECOM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MECOM (see all 4) OriGene shRNA RFP: MECOM OriGene siRNA: MECOM
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MECOM (see all 11) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MECOM (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): MECOM (NM_005241)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MECOM

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MECOM Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MECOM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MECOM

Additional cDNA sequence:

AF164154.1 AF164155.1 AF164156.1 AF164157.1 AF487422.1 AF487423.1 AF487424.1 AK025934.1

AK292865.1 AK304098.1 AK308404.1 AK310509.1 BC012450.1 BC031019.1 BC069498.1 BC130520.1

BC143951.1 BC143952.1 BX640908.1 BX647613.1 CR541866.1 CR541886.1 GQ352634.1 U43292.1

X54989.1

18 DOTS entries:

DT.97833454 DT.95188434 DT.112836 DT.97783385 DT.95365072 DT.97835453 DT.120888100 DT.102838799

DT.65286979 DT.95228866 DT.120888089 DT.91692286 DT.75173055 DT.97814361 DT.112839 DT.97767208

DT.75165091 DT.86843359

24/120 AceView cDNA sequences (see all 120):

AL699361 AA335020 AW851143 AA236533 BM788887 AI587511 BQ102518 AA335780

AI079954 BC012450 AA913663 BU741968 AL697689 BX482681 AA961157 AK025934

CB132738 AA132806 BX647613 BM984772 AI808322 BC031019 BM768941 AF487422

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MECOM (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^
SP1:													-				-		-
SP2:																																															-
SP3:																			-
SP4:			-		-		-		-		-		-				-		-
SP5:							-		-		-		-				-		-

ExUns:	17	^	18	^	19	^	20	^	21
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MECOM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MECOM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

MECOM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Zeugopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

mK3 (Cell line)

Kidney

mK4 (Cell line)

Kidney

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Beating cell clusters (Spontaneous differen...)

See MECOM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MECOM

SOURCE GeneReport for Unigene cluster: Hs.744090

SABiosciences Expression via Pathway-Focused PCR Array including MECOM:

TGFB/BMP Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MECOM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MECOM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MECOM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MECOM

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MECOM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MECOM gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mecom^{1 , 5}	MDS1 and EVI1 complex locus^{1, 5}	88.29(n)¹ 92.36(a)¹		3 (12.66 cM)⁵ 14013¹ NM_007963.2¹ NP_031989.2¹ 29951299⁵
chicken (Gallus gallus)	Aves	MECOM¹	MDS1 and EVI1 complex locus	85.01(n) 89.99(a)		424997 XM_422804.3 XP_422804.3
lizard (Anolis carolinensis)	Reptilia	MECOM⁶	--	90(a)	1 ↔ 1	3(8547143-8596943)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12493²	Transcribed sequence with moderate similarity to protein more	78.77(n)		BX713731.1
zebrafish (Danio rerio)	Actinopterygii	mecom¹	MDS1 and EVI1 complex locus	65.56(n) 69.28(a)		497407 XM_001920912.3 XP_001920947.3
fruit fly (Drosophila melanogaster)	Insecta	ham¹	hamlet	46.05(n) 38.03(a)		35135 NM_165262.3 NP_724130.3
worm (Caenorhabditis elegans)	Secernentea	egl-43⁶	EGg Laying defective family member (egl-43)	32(a)	1 → many	II(9955127-9962186)

ENSEMBL Gene Tree for MECOM (if available)
TreeFam Gene Tree for MECOM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MECOM gene

PRDM13² PRDM16²

18/142 SIMAP similar genes for MECOM using alignment to 10 protein entries: EVI1_HUMAN (see all proteins) (see all similar genes):

EVI1 ZFS-5 ZIC1 ZFS-4 kr-znf3 DKFZp686N0199

ZNF55 PRDM16 KLF7 zf30 KLF1 ZNF78L1

ZNF DKFZp686M04222 PRDM2 ZNF56 ZFS-2 ZNF72

MECOM for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73879015^1,2	C,F,	--	166171573(+)	`TTGACA/CCAAGC`	7	--	ds500¹		3		WA CSA	122
rs1048601^1,2		--	166172889(-)	`TAAAAC/TTAGGG`	7	--	ut3¹ ese³		0	--	--	--	--
rs2127299^1,2	C,H	--	166173354(+)	`CACTAG/AACTTT`	7	--	ut3¹ ese³		4		EA NS	348
rs2306279^1,2	C,H	--	166173404(+)	`GCAGTC/TTTGTA`	7	--	ut3¹ ese³		3		EA NS	294
rs6793750^1,2	C,F,A,H,	--	166173759(+)	`TTTTTG/ATAGAA`	7	--	int¹		11		EA NS NA WA	1230
rs9859712^1,2	C,H,	--	166174058(+)	`ataacC/G/Tgaaag`	7	--	int¹		4		EA NS NA	292
rs76041641^1,2	F,	--	166176442(+)	`AGTTCA/GTGGAG`	7	--	int¹		1		NA	120
rs28542627^1,2	F,	--	166179984(+)	`GATGTT/CGCAAC`	7	--	int¹		1		WA	118
rs113071472^1,2	C,F	--	166181656(+)	`GACGAT/CGTTGC`	14	/T	syn¹		2		CSA NA	4544
rs62295684^1,2	C,	--	166181800(+)	`AACTTT/CAGAAA`	7	--	int¹		3		NA	124

HapMap Linkage Disequilibrium report for MECOM (168801287 - 169051287 bp, first 250kb of MECOM)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for MECOM
6 CNVs: 79996 91697 4362 98524 5376 68502
3 Indels: 41801 62124 91698
Human Gene Mutation Database (HGMD): MECOM

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MECOM for disorders About GeneDecksing

OMIM gene information: 165215 OMIM disorders: --

UniProtKB/Swiss-Prot: MDS1_HUMAN, Q13465

Note=A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation

t(3;21)(q26;q22) with RUNX1/AML1

Note=A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation

t(3;21) with AML1

20/34 diseases for MECOM (see all 34): About MalaCards

myelodysplasia syndrome borjeson-forssman-lehmann syndrome pallister-hall syndrome denys-drash syndrome

leukemia hematopoiesis myeloid leukemia myelomonocytic leukemia

acute myelomonocytic leukemia frasier syndrome chronic granulomatous disease goldenhar syndrome

diabetes insipidus esophageal squamous cell carcinoma squamous cell carcinoma myelodysplastic syndrome

acute lymphoblastic leukemia acute myeloid leukemia chronic myeloid leukemia lymphoblastic leukemia

4 diseases from the University of Copenhagen DISEASES database for MECOM:

Nephroblastoma Pallister-Hall syndrome Leukemia Denys-Drash syndrome

10/16 Novoseek disease relationships for MECOM gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myelodysplastic syndromes	69.4	11	11243114 (2), 11721451 (2), 8700545 (1), 17409414 (1) (see all 6)
myeloid leukemia	69.2	6	8700545 (1), 17913523 (1), 10867128 (1), 12972028 (1) (see all 6)
leukemogenesis	67.7	2	12972028 (1), 16014322 (1)
leukemia	59.9	22	9183665 (4), 7808006 (2), 10867128 (2), 16156860 (1) (see all 15)
blast crisis	59.2	3	18613965 (2), 7808006 (1)
hematopoietic malignancies	58.5	1	11069022 (1)
monosomy	46.9	5	20098431 (3), 12139729 (1)
myeloid leukemia chronic	41.8	3	7808006 (2)
chromosomal aberrations	32.6	4	8700545 (1), 18619962 (1), 14704036 (1), 17243162 (1)
minimal residual disease	31.3	2	11248334 (1), 17693194 (1)

Human Genome Epidemiology (HuGE) Navigator: MECOM (3 documents)

Export disorders for MECOM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MECOM gene, integrated from 9 sources (see all 137):
(articles sorted by number of sources associating them with MECOM)

Utopia: connect your pdf to the dynamic
world of online information

Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. (PubMed id 8643684)^{1, 2, 3} Fears S....Nucifora G. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. (PubMed id 8171026)^{1, 3} Nucifora G....Rowley J.D. (1994)
Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts. (PubMed id 2115646)^{1, 3} Morishita K.... Ihle J.N. (1990)
EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. (PubMed id 11922610)^{1, 9} Shimizu S....Morishita K. (2002)
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. (PubMed id 15849193)^{1, 9} Alliston T....Derynck R. (2005)
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients. (PubMed id 12393383)^{1, 9} Barjesteh van Waalwijk van Doorn-Khosrovani S....Delwel R. (2003)
EVI-1 interacts with histone methyltransferases SUV39 H1 and G9a for transcriptional repression and bone marrow immortalization. (PubMed id 19776757)^{1, 9} Goyama S....Kurokawa M. (2010)
EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. (PubMed id 14555651)^{1, 9} Chi Y....Nucifora G. (2003)
A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. (PubMed id 18619962)^{1, 9} Spensberger D. and Delwel R. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2122	HGNC: 3498	AceView: EVI1	Ensembl:ENSG00000085276	euGenes: HUgn2122
ECgene: MECOM	Kegg: 2122	H-InvDB: MECOM

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MECOM	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MECOM	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MECOM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MECOM gene:
Search GeneIP for patents involving MECOM

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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