Aliases for MEAF6 Gene
External Ids for MEAF6 Gene
Previous HGNC Symbols for MEAF6 Gene
Previous GeneCards Identifiers for MEAF6 Gene
This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for MEAF6 Gene
MEAF6 (MYST/Esa1-Associated Factor 6) is a Protein Coding gene. Diseases associated with MEAF6 include sarcoma. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.
UniProtKB/Swiss-Prot for MEAF6 Gene
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.