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Aliases for MEAF6 Gene

Aliases for MEAF6 Gene

  • MYST/Esa1-Associated Factor 6 2 3 4
  • C1orf149 3 4 6
  • EAF6 3 4 6
  • Sarcoma Antigen NY-SAR-91 3 4
  • Centromere Protein 28 2 3
  • Protein EAF6 Homolog 3 4
  • Esa1p-Associated Factor 6 Homolog (S. Cerevisiae) 2
  • Chromatin Modification-Related Protein MEAF6 3
  • Chromosome 1 Open Reading Frame 149 2
  • Esa1p-Associated Factor 6 Homolog 3
  • Esa1-Associated Factor 6 Homolog 4
  • NY-SAR-91 3
  • CENP-28 3
  • HEAF6 4

External Ids for MEAF6 Gene

Previous HGNC Symbols for MEAF6 Gene

  • C1orf149

Previous GeneCards Identifiers for MEAF6 Gene

  • GC01M037732
  • GC01M037951
  • GC01M036075

Summaries for MEAF6 Gene

Entrez Gene Summary for MEAF6 Gene

  • This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for MEAF6 Gene

MEAF6 (MYST/Esa1-Associated Factor 6) is a Protein Coding gene. Diseases associated with MEAF6 include sarcoma. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for MEAF6 Gene

  • Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Gene Wiki entry for MEAF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEAF6 Gene

Genomics for MEAF6 Gene

Genomic Location for MEAF6 Gene

Start:
37,489,960 bp from pter
End:
37,514,819 bp from pter
Size:
24,860 bases
Orientation:
Minus strand

Genomic View for MEAF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEAF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEAF6 Gene

No data available for Regulatory Elements for MEAF6 Gene

Proteins for MEAF6 Gene

  • Protein details for MEAF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAF1-EAF6_HUMAN
    Recommended name:
    Chromatin modification-related protein MEAF6
    Protein Accession:
    Q9HAF1
    Secondary Accessions:
    • B1AK64
    • Q4F967
    • Q7Z311
    • Q86WE3

    Protein attributes for MEAF6 Gene

    Size:
    191 amino acids
    Molecular mass:
    21635 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and MEAF6. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.

    Alternative splice isoforms for MEAF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEAF6 Gene

Proteomics data for MEAF6 Gene at MOPED

Post-translational modifications for MEAF6 Gene

  • Ubiquitination at Lys26
  • Modification sites at PhosphoSitePlus

Other Protein References for MEAF6 Gene

No data available for DME Specific Peptides for MEAF6 Gene

Domains for MEAF6 Gene

Protein Domains for MEAF6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MEAF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAF1

UniProtKB/Swiss-Prot:

EAF6_HUMAN :
  • Q9HAF1
Family:
  • Belongs to the EAF6 family.
genes like me logo Genes that share domains with MEAF6: view

No data available for Gene Families for MEAF6 Gene

Function for MEAF6 Gene

Molecular function for MEAF6 Gene

UniProtKB/Swiss-Prot Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Gene Ontology (GO) - Molecular Function for MEAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MEAF6: view

miRNA for MEAF6 Gene

miRTarBase miRNAs that target MEAF6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MEAF6 Gene

Localization for MEAF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEAF6 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEAF6 Gene COMPARTMENTS Subcellular localization image for MEAF6 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MEAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 18794358
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with MEAF6: view

Pathways for MEAF6 Gene

genes like me logo Genes that share pathways with MEAF6: view

Pathways by source for MEAF6 Gene

Gene Ontology (GO) - Biological Process for MEAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043968 histone H2A acetylation IDA 14966270
GO:0043981 histone H4-K5 acetylation IDA 16387653
genes like me logo Genes that share ontologies with MEAF6: view

Transcripts for MEAF6 Gene

Unigene Clusters for MEAF6 Gene

MYST/Esa1-associated factor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEAF6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for MEAF6 Gene

GeneLoc Exon Structure for
MEAF6
ECgene alternative splicing isoforms for
MEAF6

Expression for MEAF6 Gene

mRNA expression in normal human tissues for MEAF6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MEAF6 Gene

SOURCE GeneReport for Unigene cluster for MEAF6 Gene Hs.17118

genes like me logo Genes that share expressions with MEAF6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MEAF6 Gene

Orthologs for MEAF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEAF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEAF6 35
  • 99.67 (n)
  • 100 (a)
MEAF6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEAF6 35
  • 95.85 (n)
  • 99 (a)
MEAF6 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEAF6 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meaf6 35
  • 89.45 (n)
  • 98.87 (a)
Meaf6 16
Meaf6 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEAF6 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEAF6 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meaf6 35
  • 90.05 (n)
  • 98.43 (a)
chicken
(Gallus gallus)
Aves MEAF6 35
  • 83.05 (n)
  • 96 (a)
MEAF6 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEAF6 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia meaf6 35
  • 76.61 (n)
  • 93.72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4459 35
zebrafish
(Danio rerio)
Actinopterygii meaf6 35
  • 75.26 (n)
  • 86.32 (a)
meaf6 36
  • 84 (a)
OneToOne
wufj63g06 35
fruit fly
(Drosophila melanogaster)
Insecta Eaf6 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0025.4 36
  • 33 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5500 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5309 36
  • 47 (a)
OneToOne
Species with no ortholog for MEAF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEAF6 Gene

ENSEMBL:
Gene Tree for MEAF6 (if available)
TreeFam:
Gene Tree for MEAF6 (if available)

Paralogs for MEAF6 Gene

Pseudogenes.org Pseudogenes for MEAF6 Gene

genes like me logo Genes that share paralogs with MEAF6: view

No data available for Paralogs for MEAF6 Gene

Variants for MEAF6 Gene

Sequence variations from dbSNP and Humsavar for MEAF6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9253 -- 37,493,212(-) TTGCT(C/G)GTATT utr-variant-3-prime, nc-transcript-variant
rs177347 -- 37,498,721(+) ccaca(C/G)cacct intron-variant
rs215210 -- 37,493,849(-) ATCCC(A/G)GCAAG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs215211 -- 37,493,869(-) AAGAT(C/G)AAGAC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs215212 -- 37,493,898(-) TATGT(C/G)ATTTT utr-variant-3-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MEAF6 Gene

Variant ID Type Subtype PubMed ID
nsv483134 CNV Loss 15286789
nsv519551 CNV Gain 19592680
nsv524834 CNV Gain 19592680
esv2666365 CNV Deletion 23128226

Relevant External Links for MEAF6 Gene

HapMap Linkage Disequilibrium report
MEAF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEAF6 Gene

Disorders for MEAF6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MEAF6 Gene including...

Search for MEAF6 Gene in MalaCards »

UniProtKB/Swiss-Prot

EAF6_HUMAN
  • Note=A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1. {ECO:0000269 PubMed:22761769}.

(1) University of Copenhagen DISEASES for MEAF6 Gene

Relevant External Links for MEAF6

Genetic Association Database (GAD)
MEAF6
genes like me logo Genes that share disorders with MEAF6: view

Publications for MEAF6 Gene

  1. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PMID: 14966270) Doyon Y. … Cote J. (Mol. Cell. Biol. 2004) 2 3 4
  2. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 2 3 4
  3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 2 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MEAF6 Gene

Sources for MEAF6 Gene

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