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MEAF6 Gene

protein-coding   GIFtS: 50
GCID: GC01M037951

MYST/Esa1-Associated Factor 6

(Previous name: chromosome 1 open reading frame 149)
(Previous symbol: C1orf149)
  See MEAF6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MYST/Esa1-Associated Factor 61 2 3     Esa1p-Associated Factor 6 Homolog (S. Cerevisiae)1
C1orf1491 2 3 5     CENP-282
EAF62 3 5     NY-SAR-912
Centromere Protein 281 2     Chromatin Modification-Related Protein MEAF62
Protein EAF6 Homolog2 3     Esa1p-Associated Factor 6 Homolog2
Sarcoma Antigen NY-SAR-912 3     Esa1-Associated Factor 6 Homolog3
Chromosome 1 Open Reading Frame 1491     hEAF63

External Ids:    HGNC: 256741   Entrez Gene: 647692   Ensembl: ENSG000001638757   OMIM: 6110015   UniProtKB: Q9HAF13   

Export aliases for MEAF6 gene to outside databases

Previous GC identifers: GC01M037732 GC01M036075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MEAF6 Gene:
This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a
component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on
chromosome 2. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for MEAF6 Gene:
MEAF6 (MYST/Esa1-associated factor 6) is a protein-coding gene. Diseases associated with MEAF6 include sarcoma.

UniProtKB/Swiss-Prot: EAF6_HUMAN, Q9HAF1
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific
acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4
acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity

Gene Wiki entry for MEAF6 (C1orf149) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MEAF6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMEAF6 promoter sequence
   Search Chromatin IP Primers for MEAF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MEAF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3-p33   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p35.3-p33

MEAF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEAF6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M037951:  view genomic region     (about GC identifiers)

Start:
37,958,176 bp from pter      End:
37,980,375 bp from pter
Size:
22,200 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EAF6_HUMAN, Q9HAF1 (See protein sequence)
Recommended Name: Chromatin modification-related protein MEAF6  
Size: 191 amino acids; 21635 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the
subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4,
VPS72 and MEAF6. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of
JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one
of BRPF1, BRD1/BRPF2 and BRPF3
Secondary accessions: B1AK64 Q4F967 Q7Z311 Q86WE3
Alternative splicing: 4 isoforms:  Q9HAF1-1   Q9HAF1-2   Q9HAF1-3   Q9HAF1-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MEAF6: NX_Q9HAF1

Explore proteomics data for MEAF6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys26
  • Modification sites at PhosphoSitePlus

  • See MEAF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257804.1  NP_001257805.1  NP_073593.2  

    ENSEMBL proteins: 
     ENSP00000362166   ENSP00000296214   ENSP00000362165   ENSP00000362164   ENSP00000394966  
    Reactome Protein details: Q9HAF1

    MEAF6 Human Recombinant Protein Products:

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    Novus Biologicals MEAF6 Lysate
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    Cloud-Clone Corp. Proteins for MEAF6

     
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    Cloud-Clone Corp. ELISAs for MEAF6
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    Search eBioscience for ELISAs for MEAF6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR015418 Hist_AcTrfase_NuA4_cplx

    Graphical View of Domain Structure for InterPro Entry Q9HAF1

    ProtoNet protein and cluster: Q9HAF1

    UniProtKB/Swiss-Prot: EAF6_HUMAN, Q9HAF1
    Similarity: Belongs to the EAF6 family


    Find genes that share domains with MEAF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EAF6_HUMAN, Q9HAF1
    Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
    of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
    positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific
    acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4
    acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with MEAF6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MEAF6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MEAF6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MEAF6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MEAF6

    miRNA
    Products:
        
    miRTarBase miRNAs that target MEAF6:
    hsa-mir-26b-5p (MIRT029489), hsa-mir-10a-5p (MIRT047703)

    Block miRNA regulation of human, mouse, rat MEAF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEAF6 (see all 26):
    hsa-miR-3910 hsa-miR-3194-5p hsa-miR-495 hsa-miR-300 hsa-miR-125a-3p hsa-miR-513a-5p hsa-miR-507 hsa-miR-197
    SwitchGear 3'UTR luciferase reporter plasmidMEAF6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat MEAF6

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for MEAF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MEAF6 (NM_022756)
    Sino Biological Human cDNA Clone for MEAF6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEAF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEAF6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MEAF6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEAF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EAF6_HUMAN, Q9HAF1: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with MEAF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MEAF6 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with MEAF6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MEAF6
        HATs acetylate histones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MEAF6
    Interactions:

        Search GeneGlobe Interaction Network for MEAF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MEAF6 (Q9HAF11, 3 ENSP000003621664) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FXR2P511161, 3, ENSP000002501134EBI-399266,EBI-740459 I2D: score=4 STRING: ENSP00000250113
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    BRPF1P552013, ENSP000003733404I2D: score=1 STRING: ENSP00000373340
    ING4Q9UNL43, ENSP000003800244I2D: score=1 STRING: ENSP00000380024
    JADE1Q6IE813, ENSP000002263194I2D: score=1 STRING: ENSP00000226319
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0043968histone H2A acetylation IDA14966270
    GO:0043981histone H4-K5 acetylation IDA16387653

    Find genes that share ontologies with MEAF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MEAF6 (EAF6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MEAF6 gene (3 alternative transcripts): 
    NM_001270875.1  NM_001270876.1  NM_022756.5  

    Unigene Cluster for MEAF6:

    MYST/Esa1-associated factor 6
    Hs.17118  [show with all ESTs]
    Unigene Representative Sequence: NR_073092
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373075(uc001cbd.1 uc001cbe.1 uc009vvd.1 uc001cbg.1)
    ENST00000296214 ENST00000373074 ENST00000475828 ENST00000487788 ENST00000373073
    ENST00000487792 ENST00000485039 ENST00000448519(uc001cbh.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MEAF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MEAF6 (see all 26):
    hsa-miR-3910 hsa-miR-3194-5p hsa-miR-495 hsa-miR-300 hsa-miR-125a-3p hsa-miR-513a-5p hsa-miR-507 hsa-miR-197
    SwitchGear 3'UTR luciferase reporter plasmidMEAF6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MEAF6
    Predesigned siRNA for gene silencing in human, mouse, rat MEAF6
    Clone
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    OriGene clones in human, mouse for MEAF6 (see all 6)
    OriGene ORF clones in mouse, rat for MEAF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MEAF6 (NM_022756)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MEAF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEAF6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MEAF6
    OriGene qSTAR qPCR primer pairs in human, mouse for MEAF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MEAF6
      QuantiTect SYBR Green Assays in human, mouse, rat MEAF6
      QuantiFast Probe-based Assays in human, mouse, rat MEAF6

    Additional mRNA sequence: 

    AK021792.1 AK225434.1 AK225598.1 AK308118.1 AK309663.1 AY007166.1 AY211926.1 BC016328.1 
    BC056406.1 BX538212.1 BX640719.1 DQ099384.1 NR_073090.1 NR_073091.1 NR_073092.1 

    11 DOTS entries:

    DT.456359  DT.100809368  DT.100809365  DT.99995626  DT.97846797  DT.100809369  DT.100676830  DT.121329206 
    DT.95288218  DT.100809363  DT.95242795 

    Selected AceView cDNA sequences (see all 332):

    AI655153 CR596619 BU679798 BM920553 CR591880 CR611127 AI866210 AW006273 
    CA423831 AI033466 AA594861 AW182986 BF794704 BE792362 BQ929565 AA427401 
    AI401215 AY007166 AW016856 AA768585 AW590942 AW590669 CR590031 CD675515 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MEAF6    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                          -                             -                     
    SP2:                          -                             -     -               
    SP3:                          -                             -     -     -         
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for MEAF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MEAF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAAGGAAC
    MEAF6 Expression
    About this image

    MEAF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MEAF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17118
        Custom PCR Arrays for MEAF6
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MEAF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MEAF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MEAF6 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Meaf61 , 5 MYST/Esa1-associated factor 61, 5 89.45(n)1
    98.87(a)1
      4 (58.03 cM)5
    700881  NM_027310.31  NP_081586.11 
     1250851345 
    chicken
    (Gallus gallus)
    Aves MEAF61 MYST/Esa1-associated factor 6 83.05(n)
    96(a)
      419617  NM_001030897.1  NP_001026068.1 
    lizard
    (Anolis carolinensis)
    Reptilia MEAF66
    MYST/Esa1-associated factor 6
    95(a)
    1 ↔ 1
    GL343426.1(445312-453771)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA971255.12   -- 77.26(n)    CA971255.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj63g062 Transcribed sequence with moderate similarity to protein more 76.76(n)    CK352822.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eaf66
    Eaf6
    36(a)
    1 ↔ 1
    3L(5600262-5601400)
    worm
    (Caenorhabditis elegans)
    Secernentea B0025.46
    Protein B0025.4 (B0025.4) mRNA, complete cds
    33(a)
    1 ↔ 1
    I(6027194-6028370) WBGene00015001


    ENSEMBL Gene Tree for MEAF6 (if available)
    TreeFam Gene Tree for MEAF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MEAF6 gene

    Find genes that share paralogs with MEAF6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MEAF6
    PGOHUM00000241097


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MEAF6 (see all 541)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431416151,2
    --37955195(+) CACAGC/GTAGAA 6 -- ds50010--------
    rs1833847391,2
    --37955785(+) CCCTCC/TTCCCC 6 -- nc-transcript-variantut310--------
    rs1482370731,2
    --37955825(+) GCATCA/GACTCC 6 -- nc-transcript-variantut310--------
    rs414393441,2
    C,F,H--37955866(+) TAATCC/TACGGA 6 -- nc-transcript-variantut3122Minor allele frequency- T:0.07NS EA NA 2376
    rs1412493021,2
    --37955869(+) TCCACA/GGAAGC 6 -- nc-transcript-variantut310--------
    rs1863506301,2
    --37955890(+) AGTGAA/GAACTG 6 -- nc-transcript-variantut310--------
    rs1908422751,2
    --37955934(+) CAGACA/GAGGTA 6 -- nc-transcript-variantut310--------
    rs1829908251,2
    --37955955(+) AGACTC/GACACA 6 -- nc-transcript-variantut310--------
    rs1875278141,2
    --37955990(+) TTTCAC/TTATCA 6 -- nc-transcript-variantut310--------
    rs1930048821,2
    --37956004(+) TATCTA/GACACA 6 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for MEAF6 (37958176 - 37980375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MEAF6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666365CNV Deletion23128226
    nsv483134CNV Loss15286789
    nsv519551CNV Gain19592680
    nsv524834CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MEAF6
    DNA2.0 Custom Variant and Variant Library Synthesis for MEAF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611001    OMIM disorders: --

    UniProtKB/Swiss-Prot: EAF6_HUMAN, Q9HAF1
  • Note=A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation
    t(1;6)(p34;p21) with PHF1

  • 1 disease for MEAF6:    
    About MalaCards
    sarcoma

    1 disease from the University of Copenhagen DISEASES database for MEAF6:
    Endometrial stromal sarcoma

    Find genes that share disorders with MEAF6           About GenesLikeMe

    Genetic Association Database (GAD): MEAF6

    Export disorders for MEAF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MEAF6 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with MEAF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2, 3 Doyon Y.... Cote J. (Mol. Cell 2006)
    2. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2, 3 Doyon Y.... Cote J. (Mol. Cell. Biol. 2004)
    3. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 3 Cai Y.... Conaway J.W. (J. Biol. Chem. 2003)
    4. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PubMed id 18794358)1, 2 Ullah M....Yang X.-J. (Mol. Cell. Biol. 2008)
    5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1, 4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PubMed id 15647280)1, 2 Cai Y.... Conaway J.W. (J. Biol. Chem. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64769 HGNC: 25674 AceView: FLJ11730 Ensembl:ENSG00000163875 euGenes: HUgn64769
    ECgene: MEAF6 H-InvDB: MEAF6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MEAF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MEAF6 gene:
    Search GeneIP for patents involving MEAF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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