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Aliases for MEA1 Gene

Aliases for MEA1 Gene

  • Male-Enhanced Antigen 1 2 3 5
  • MEA 3 4
  • Male-Enhanced Antigen (H-Y Structural Gene) 3
  • Male-Enhanced Antigen 2
  • MEA-1 4
  • HYS 3

External Ids for MEA1 Gene

Previous HGNC Symbols for MEA1 Gene

  • MEA

Previous GeneCards Identifiers for MEA1 Gene

  • GC06M043088
  • GC06M042979
  • GC06M042697

Summaries for MEA1 Gene

GeneCards Summary for MEA1 Gene

MEA1 (Male-Enhanced Antigen 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEA1 Gene

  • May play an important role in spermatogenesis and/or testis development.

Additional gene information for MEA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEA1 Gene

Genomics for MEA1 Gene

Regulatory Elements for MEA1 Gene

Enhancers for MEA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H042901 1.5 Ensembl ENCODE dbSUPER 10.8 +114.0 114037 3.3 FOXA2 ARNT ZFP64 ARID4B DMAP1 ZNF2 YY1 TCF12 SLC30A9 ZNF143 RPL7L1 PEX6 CNPY3 ENSG00000231113 PPP2R5D KLC4 RN7SL403P CUL7 KLHDC3 MEA1
GH06H042928 1.4 ENCODE dbSUPER 10.8 +86.3 86299 5.6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF610 PEX6 ZNF318 POLH XPO5 RRP36 CUL7 GTPBP2 ABCC10 PPP2R5D RPS2P29
GH06H043141 1.3 Ensembl ENCODE 10.8 -126.4 -126376 3.6 HDGF ARID4B SIN3A ZNF2 ZNF143 SP5 MXD4 REST ZNF592 KAT8 CUL7 DNPH1 KLC4 RN7SL403P KLHDC3 MEA1 PPP2R5D RPL7L1 SRF PIR51341
GH06H043119 1.3 Ensembl ENCODE dbSUPER 10.5 -106.3 -106303 8.7 ZBTB21 ZIC2 ZNF324 ZNF121 ZFHX2 GLIS2 POLR2A ZBTB48 EGR1 SCRT2 CUL7 PTK7 KLC4 RN7SL403P PPP2R5D ENSG00000231113 CNPY3 DNPH1 MEA1 KLHDC3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEA1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MEA1 Gene

Genomic Locations for MEA1 Gene
36,744 bases
Minus strand

Genomic View for MEA1 Gene

Genes around MEA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEA1 Gene

Proteins for MEA1 Gene

  • Protein details for MEA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Male-enhanced antigen 1
    Protein Accession:
    Secondary Accessions:
    • Q5TC36
    • Q9BV01

    Protein attributes for MEA1 Gene

    185 amino acids
    Molecular mass:
    19905 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEA1 Gene

Post-translational modifications for MEA1 Gene

  • Ubiquitination at Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for MEA1 Gene

No data available for DME Specific Peptides for MEA1 Gene

Domains & Families for MEA1 Gene

Gene Families for MEA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MEA1 Gene


Suggested Antigen Peptide Sequences for MEA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEA1: view

No data available for UniProtKB/Swiss-Prot for MEA1 Gene

Function for MEA1 Gene

Molecular function for MEA1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in spermatogenesis and/or testis development.

Phenotypes From GWAS Catalog for MEA1 Gene

Gene Ontology (GO) - Molecular Function for MEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MEA1: view
genes like me logo Genes that share phenotypes with MEA1: view

Animal Model Products

CRISPR Products

miRNA for MEA1 Gene

miRTarBase miRNAs that target MEA1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEA1 Gene

Localization for MEA1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEA1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MEA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEA1 Gene

Pathways & Interactions for MEA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA,TAS --
GO:0008584 male gonad development TAS 2813404
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MEA1: view

No data available for Pathways by source and SIGNOR curated interactions for MEA1 Gene

Drugs & Compounds for MEA1 Gene

No Compound Related Data Available

Transcripts for MEA1 Gene

Unigene Clusters for MEA1 Gene

Male-enhanced antigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b

Relevant External Links for MEA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEA1 Gene

Protein differential expression in normal tissues from HIPED for MEA1 Gene

This gene is overexpressed in Adipocyte (19.2), Fetal Brain (13.4), Lung (11.3), and Bone (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEA1 Gene

Protein tissue co-expression partners for MEA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MEA1 Gene:


SOURCE GeneReport for Unigene cluster for MEA1 Gene:


mRNA Expression by UniProt/SwissProt for MEA1 Gene:

Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for MEA1 Gene

  • Liver(4.4)
  • Eye(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with MEA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEA1 Gene

Orthologs for MEA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEA1 33 34
  • 99.82 (n)
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
MEA1 33 34
  • 93.22 (n)
(Canis familiaris)
Mammalia MEA1 33 34
  • 91.39 (n)
(Rattus norvegicus)
Mammalia Mea1 33
  • 91.09 (n)
(Mus musculus)
Mammalia Mea1 33 16 34
  • 90.64 (n)
(Monodelphis domestica)
Mammalia MEA1 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia MEA1 34
  • 66 (a)
(Anolis carolinensis)
Reptilia MEA1 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mea1 33
  • 64.78 (n)
Str.10548 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18937 33
(Danio rerio)
Actinopterygii mea1 33 34
  • 60.34 (n)
Species where no ortholog for MEA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEA1 Gene

Gene Tree for MEA1 (if available)
Gene Tree for MEA1 (if available)

Paralogs for MEA1 Gene

No data available for Paralogs for MEA1 Gene

Variants for MEA1 Gene

Sequence variations from dbSNP and Humsavar for MEA1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs757369209 Pathogenic 43,006,514(+) AGCCA(A/C/T)CGTCA intron-variant, reference, missense, utr-variant-5-prime
rs863225079 Pathogenic 43,007,271(+) AAGAT(A/G)AGCCC intron-variant, reference, missense
rs863225080 Pathogenic 43,009,328(+) TGGCA(A/G)AGCGT intron-variant, reference, missense
rs863225081 Pathogenic 43,007,262(+) ACCCA(A/G)AGGAA intron-variant, reference, missense
rs863225082 Pathogenic 43,007,265(+) CAGAG(A/G)AAGAT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MEA1 Gene

Variant ID Type Subtype PubMed ID
nsv602992 CNV loss 21841781
nsv462930 CNV loss 19166990
nsv462927 CNV loss 19166990
nsv1074927 CNV deletion 25765185
nsv1017398 CNV gain 25217958
dgv10640n54 CNV loss 21841781

Variation tolerance for MEA1 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEA1 Gene

Disorders for MEA1 Gene

Relevant External Links for MEA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MEA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEA1 Gene

Publications for MEA1 Gene

  1. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. (PMID: 2813404) Lau YF … Sparkes R (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. (PMID: 12444059) Ohinata Y … Mitsui Y (Biology of reproduction 2002) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for MEA1 Gene

Sources for MEA1 Gene

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