MEA1 Gene
protein-coding GIFtS: 46
GCID: GC06M042979
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male-enhanced antigen 1(Previous name: male-enhanced antigen )
(Previous symbol: MEA)
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Aliases
for MEA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Male-Enhanced Antigen 11 2 | | MEA1 2 3 5 | | MEA-12 3 | | Male-Enhanced Antigen1 | | HYS2 | | Male-Enhanced Antigen (H-Y Structural Gene)2 |
Export aliases for MEA1 gene to outside databasesPrevious GC identifers: GC06M043088 GC06M042697 |
Summaries
for MEA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MEA1_HUMAN, Q16626Function: May play an important role in spermatogenesis and/or testis development
|
Genomic Views
for MEA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEA1 gene promoter:
E2F-3a E2F-4 E2F-5 HTF E2F-2 C/EBPalpha CHOP-10 Egr-2 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3-p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.3-p21.1MEA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M042979: view genomic region
(about GC identifiers)
Start:
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42,979,832 bp from pter |
End:
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42,981,706 bp from pter |
Size:
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1,875 bases |
Orientation:
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minus strand |
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Proteins
for MEA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MEA1_HUMAN, Q16626 (See
protein sequence)Recommended Name: Male-enhanced antigen 1 Size: 185 amino acids; 19905 Da
Caution: Was originally thought to be the H-Y antigen
Caution: It is uncertain whether Met-1, Met-14 or Met-24 is the initiator
Secondary accessions: Q5TC36 Q9BV01Explore the universe of human proteins at neXtProt for MEA1: NX_Q16626
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16626
MEA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055438.1
ENSEMBL proteins: ENSP00000244711
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
MEA1 for ontologies About GeneDecksing
MEA1 Antibody Products:
Assay Products for MEA1: |
Protein
Domains /
Families
for MEA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q16626ProtoNet protein and cluster: Q16626 1 Blocks protein family: IPB009685 Male enhanced antigen 1
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Function
for MEA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MEA1_HUMAN, Q16626Function: May play an important role in spermatogenesis and/or testis development
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MEA1 (NM_014623) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEA1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
MEA1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MEA1:
|
Pathways & Interactions
for MEA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MEA1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for MEA1 (Q166261, 2, 3 ENSP000002447114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MEA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MEA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MEA1
Search CenterWatch for drugs/clinical trials and news about MEA1
|
Transcripts
for MEA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MEA1 gene: NM_014623.2 Unigene Cluster for MEA1: Male-enhanced antigen 1 Hs.278362 [show with all ESTs]Unigene Representative Sequence: BI2243741 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000244711(uc010jyc.1 uc003otk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MEA1 (NM_014623) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MEA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEA1 |
Additional cDNA sequence: AK309759.1 BC001754.1 BT009831.1 L10400.1 M27937.1 18 DOTS entries: DT.101976805 DT.40124305 DT.100677856 DT.100816626 DT.92454606 DT.95272004 DT.100816620 DT.95272009 DT.100816630 DT.121385635 DT.95339998 DT.121385663 DT.121385690 DT.121385720 DT.95272003 DT.97854895 DT.100816633 DT.95272008 24/263 AceView cDNA sequences (see all 263): BE910468 BF724204 AA477552 BQ787513 BM564153 AA070738 BU845658 CA417378 T29913 BU178497 BU630642 BM917403 AA477669 CK820904 AV656575 CR606344 BQ227342 BG112981 BM726720 BQ686119 AI401510 BU857373 BQ689071 NM_014623
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MEA1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MEA1
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Expression
for MEA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MEA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MEA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MEA1
SOURCE GeneReport for Unigene cluster: Hs.278362
UniProtKB/Swiss-Prot: MEA1_HUMAN, Q16626Tissue specificity: Highly expressed in testis
SABiosciences Custom PCR Arrays for MEA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MEA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEA1 |
Orthologs
for MEA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MEA1 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for MEA1 (if available)
TreeFam Gene Tree for MEA1 (if available) |
Paralogs
for MEA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MEA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MEA1 (42979832 - 42981706 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MEA1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEA1 |
|
Disorders
/ Diseases
for MEA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MEA1 for disorders About MalaCards
MEA1 for disorders About GeneDecksing
OMIM gene information: 143170
OMIM disorders: --
Export disorders for MEA1 gene to outside databases
|
Publications
for MEA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MEA1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MEA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. (PubMed id 2813404)1, 2, 3 Lau Y.-F.C.... Sparkes R.S. (1989)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Male-enhanced antigen-1 gene flanked by two overlappi ng genes is expressed in late spermatogenesis. (PubMed id 12444059)1, 3 Ohinata Y....Mitsui Y. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
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External Searches for MEA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MEA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MEA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MEA1 gene:
Search GeneIP for patents involving MEA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MEA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MEA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MEA1 | | | OriGene Protein Over-expression Lysate for MEA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MEA1 | | OriGene 3'-UTR Clone for MEA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MEA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MEA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MEA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MEA1 | | OriGene Custom Protein Services for MEA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MEA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MEA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MEA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MEA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MEA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MEA1 |
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| | | | Search Tocris compounds for MEA1 |
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 | | | MEA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MEA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MEA1 |
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