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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ME3 Gene

protein-coding   GIFtS: 58
GCID: GC11M086152

Malic Enzyme 3, NADP(+)-Dependent, Mitochondrial

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Malic Enzyme 3, NADP(+)-Dependent, Mitochondrial1 2     Mitochondrial NADP(+)-Dependent Malic Enzyme 32
NADP-ME2 3     NADP-Dependent Malic Enzyme, Mitochondrial2
EC 1.1.1.403 8     Pyruvic-Malic Carboxylase2
Malate Dehydrogenase2     Malic Enzyme 33
Malic Enzyme, NADP+-Dependent, Mitochondrial2     EC 1.1.18

External Ids:    HGNC: 69851   Entrez Gene: 108732   Ensembl: ENSG000001513767   OMIM: 6046265   UniProtKB: Q167983   

Export aliases for ME3 gene to outside databases

Previous GC identifers: GC11M088478 GC11M087691 GC11M086374 GC11M085878 GC11M085829 GC11M082440


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ME3 Gene:
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a
cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a
mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a
mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for
this gene, but the biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ME3 Gene: 
ME3 (malic enzyme 3, NADP(+)-dependent, mitochondrial) is a protein-coding gene. Diseases associated with ME3 include fascioliasis, and tuberculosis, and among its related super-pathways are Metabolism and Biosynthesis of amino acids. GO annotations related to this gene include NAD binding and malic enzyme activity. An important paralog of this gene is ME2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ME3 gene promoter:
         IRF-2   Tal-1   POU3F2 (N-Oct-5a)   POU3F2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidME3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ME3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ME3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11cen-q22.3   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

ME3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ME3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M086152:  view genomic region     (about GC identifiers)

Start:
86,152,150 bp from pter      End:
86,383,678 bp from pter
Size:
231,529 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAON_HUMAN, Q16798 (See protein sequence)
Recommended Name: NADP-dependent malic enzyme, mitochondrial precursor  
Size: 604 amino acids; 67068 Da
Cofactor: Divalent metal cations. Prefers magnesium or manganese (By similarity)
Subcellular location: Mitochondrion matrix

Explore the universe of human proteins at neXtProt for ME3: NX_Q16798

Explore proteomics data for ME3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16798

  • 4/20 DME Specific Peptides for ME3 (Q16798) (see all 20)
     VYTPTVG  FASGSPF  DVGTNNE  AFTEQIL 

    ME3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ME3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001014811.1  NP_006671.2  NP_001155058.1  

    ENSEMBL proteins: 
     ENSP00000376998   ENSP00000431182   ENSP00000433636   ENSP00000434690   ENSP00000435427  
     ENSP00000437204   ENSP00000434431   ENSP00000352657   ENSP00000440246   ENSP00000315255  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ME3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS7818469
    GO:0005759mitochondrial matrix IEA--

    ME3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR012301 Malic_N
     IPR012302 Malic_NAD-bd
     IPR015884 Malic_enzyme_CS
     IPR001891 Malic_OxRdtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q16798

    ProtoNet protein and cluster: Q16798

    1 Blocks protein domain: IPB001891 Malic oxidoreductase

    UniProtKB/Swiss-Prot: MAON_HUMAN, Q16798
    Similarity: Belongs to the malic enzymes family


    ME3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAON_HUMAN, Q16798
    Catalytic activity: (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH
    Catalytic activity: Oxaloacetate = pyruvate + CO(2)

         Genatlas biochemistry entry for ME3:
    malic enzyme 3, NADP(+)-dependent, mitochondrial,predominantly expressed in tissues with a low division
    rate,catalyzing the decarboxylation of malate to pyruvate

         Enzyme Numbers (IUBMB): EC 1.1.1.401 2 EC 1.1.12

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004470malic enzyme activity IDA7818469
    GO:0004473malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity IDA7818469
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0016619malate dehydrogenase (oxaloacetate-decarboxylating) activity IEA--
    GO:0046872metal ion binding IEA--
         
    ME3 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ME3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Carbon metabolism
    Carbon metabolism0.37
    3Pyruvate metabolism
    Pyruvate metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for ME3):
        Pyruvate metabolism
    Metabolic pathways
    Carbon metabolism


    ME3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ME3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for ME3 (Q167983 ENSP000003526574) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKBP122773I2D: score=4 
    LDHAL6AENSP000002807064STRING: ENSP00000280706
    LDHAL6BENSP000003023934STRING: ENSP00000302393
    LDHBENSP000002293194STRING: ENSP00000229319
    LDHCENSP000002807044STRING: ENSP00000280704
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process IDA7818469
    GO:0006108malate metabolic process IDA7818469
    GO:0009060aerobic respiration TAS7818469
    GO:0055114oxidation-reduction process IDA7818469
    GO:0072592oxygen metabolic process TAS7818469

    ME3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ME3 (MAON)

    10 HMDB Compounds for ME3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    L-Malic acid(-)-(S)-Malate (see all 27)97-67-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Malic acid2-Hydroxybutanedioic acid (see all 24)6915-15-7--
    Manganesemanganese 7439-96-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    3 DrugBank Compounds for ME3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17080607 16740313 17603759
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235
    Tartronate-- --target--17139284 17016423 10592235

    Search CenterWatch for drugs/clinical trials and news about ME3 / MAON

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ME3 gene (3 alternative transcripts): 
    NM_001014811.1  NM_006680.2  NM_001161586.1  

    Unigene Cluster for ME3:

    Malic enzyme 3, NADP(+)-dependent, mitochondrial
    Hs.199743  [show with all ESTs]
    Unigene Representative Sequence: NM_001161586
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393324(uc001pbz.3) ENST00000524826 ENST00000530520 ENST00000526504(uc010rtr.1)
    ENST00000525957 ENST00000530335 ENST00000534638 ENST00000532471 ENST00000526834
    ENST00000526944 ENST00000359636(uc001pca.3) ENST00000543262(uc009yvk.3)
    ENST00000323418
    miRNA
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    Additional mRNA sequence: 

    AK092181.1 AK300974.1 AK313695.1 AY424278.1 BC022472.2 X79440.1 

    17 DOTS entries:

    DT.102828818  DT.451469  DT.451443  DT.75102420  DT.75184418  DT.97842348  DT.108321  DT.75130260 
    DT.86853011  DT.100021624  DT.120735142  DT.100782908  DT.100782909  DT.40285888  DT.97842347  DT.91844743 
    DT.99935893 

    24/133 AceView cDNA sequences (see all 133):

    BM665443 AU139491 AA350296 CB851088 BE503563 BQ882896 AA132644 CB132135 
    AI743966 BM787648 AI088692 BX646131 CK820058 BF062610 BM354089 CD514548 
    BX369939 F07791 BU687977 NM_006680 BP381579 F04050 BM738654 AI624172 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ME3 expression in normal human tissues (normalized intensities)      ME3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTTCAGA
    ME3 Expression
    About this image


    ME3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Ureter
             visceral organ   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Eye (Sensory Organs)
             sensory organ/eye/cornea   

    See ME3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ME3

    SOURCE GeneReport for Unigene cluster: Hs.199743

    UniProtKB/Swiss-Prot: MAON_HUMAN, Q16798
    Tissue specificity: Expressed predominantly in organs with a low-division rate

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ME3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ME3 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Me31 , 5 malic enzyme 3, NADP(+)-dependent, mitochondrial1, 5 89.29(n)1
    94.21(a)1
      7 (50.27 cM)5
    1092641  NM_181407.41  NP_852072.21 
     896323925 
    chicken
    (Gallus gallus)
    Aves ME31 malic enzyme 3, NADP(+)-dependent, mitochondrial 72.18(n)
    77.46(a)
      419019  XM_003640570.1  XP_003640618.1 
    lizard
    (Anolis carolinensis)
    Reptilia ME36
    malic enzyme 3, NADP(+)-dependent, mitochondrial
    78(a)
    1 ↔ 1
    3(200211728-200347842)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.63242 Xenopus laevis transcribed sequence with weak similarity more 75.81(n)    BQ897346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA474606.12   -- 74.4(n)    CA474606.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Men1 , 3 malate dehydrogenase (oxaloacetate
    decarboxylating) more3
    Malic enzyme1
    56(a)
    (best of 5)3
    60.05(n)1
    56.55(a)1
      471731  NM_080141.31  NP_524880.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48B6A.123
    men-11
    Protein MEN-11 54(a)3
    58.08(n)1
    55.46(a)1
      II(14226477-14233689)3
    1750791  NM_064567.31  NP_496968.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAE16
    Mitochondrial malic enzyme, catalyzes the oxidativ...
    30(a)
    1 → many
    XI(382716-384725)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NADP-ME41 NADP-malic enzyme 4 53.45(n)
    49.48(a)
      844314  NM_106624.4  NP_178093.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01863001 hypothetical protein 56.68(n)
    51.12(a)
      4338007  NM_001061367.1  NP_001054832.1 


    ENSEMBL Gene Tree for ME3 (if available)
    TreeFam Gene Tree for ME3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ME3 gene
    ME22  ME12  
    18/44 SIMAP similar genes for ME3 using alignment to 11 protein entries:     MAON_HUMAN (see all proteins) (see all similar genes):
    ME1    PCDHGA10    ME2    PCDHGA1    PCDHGA6    PCDHB11
    PCDHGA3    PCDHB12    ME6    DKFZp586I1919    PCDHB7    PCDHB8
    ME4    PCDHB2    PCDHB3    PCDHGB1    PCDHB6    PCDHB9

    ME3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5171 SNPs in ME3 are shown (see all 5171)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs718815861,2
    C--82475456(+) TATAT-/AGAG  
            
    AGAGA
    3 -- int10--------
    rs122947561,2
    C,F,H--86151721(+) CACTGC/TCGAGA 3 -- ds5001 int19Minor allele frequency- T:0.11NS EA NA CSA WA 637
    rs1381668341,2
    --86151821(+) TCCCC-/ATGACT
            
    CCCAC
    3 -- ds5001 int10--------
    rs1885091661,2
    --86151834(+) CACCCA/GTCTTT 3 -- int1 ds50010--------
    rs783547211,2
    F--86151889(+) TCTTAC/TATTTC 3 -- ds5001 int11Minor allele frequency- T:0.03NA 120
    rs122816451,2
    C,F,H--86151931(+) CCCTCA/TGTTTT 3 -- ds5001 int110Minor allele frequency- T:0.11NS EA NA CSA WA 783
    rs122830351,2
    C,F,H--86151995(+) GTCCAA/GTCTCC 3 -- ds5001 int113Minor allele frequency- G:0.12NS EA NA CSA WA 925
    rs1164650091,2
    F--86152081(+) TTGGTG/AATTAA 3 -- ds5001 int11Minor allele frequency- A:0.03WA 118
    rs769124991,2
    C,F--86152192(+) ATCTCC/TTCTCA 3 -- ut311Minor allele frequency- T:0.17WA 118
    rs1808865111,2
    --86152241(+) TTCACC/TTGGGC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ME3 (86152150 - 86383678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for ME3 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672841CNV Deletion23128226
    dgv230e199CNV Deletion23128226
    esv2662437CNV Deletion23128226
    esv4749CNV Deletion18987735
    esv2668174CNV Deletion23128226
    esv2744855CNV Deletion23290073
    esv2678915CNV Deletion23128226
    esv2744856CNV Deletion23290073
    esv267584CNV Insertion20981092
    nsv510265CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604626    OMIM disorders: --

    2 diseases for ME3:    About MalaCards
    fascioliasis    tuberculosis


    ME3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ME3
    Human Genome Epidemiology (HuGE) Navigator: ME3 (4 documents)

    Export disorders for ME3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ME3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ME3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. (PubMed id 7818469)1, 2, 3 Loeber G.... Schwendenwein R. (1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. Proteome analysis of the thalamus and cerebrospinal f luid reveals glycolysis dysfunction and potential biomarkers candidates for sch izophrenia. (PubMed id 20471030)1 Martins-de-Souza D....Turck C.W. (2010)
    6. Functional roles of the tetramer organization of mali c enzyme. (PubMed id 19416979)1 Hsieh J.Y....Hung H.C. (2009)
    7. Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme. (PubMed id 19236308)1 Hsieh J.Y....Hung H.C. (2009)
    8. Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of the nucleotide binding site Lys346. (PubMed id 18959763)1 Hsieh J.Y....Hung H.C. (2008)
    9. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (2007)
    10. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10873 HGNC: 6985 AceView: ME3 Ensembl:ENSG00000151376 euGenes: HUgn10873
    ECgene: ME3 Kegg: 10873 H-InvDB: ME3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ME3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ME3 gene:
    Search GeneIP for patents involving ME3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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