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Aliases for ME3 Gene

Aliases for ME3 Gene

  • Malic Enzyme 3 2 4
  • Malic Enzyme 3, NADP(+)-Dependent, Mitochondrial 2 3 5
  • EC 4 63
  • NADP-ME 3 4
  • Malate Dehydrogenase (Oxaloacetate-Decarboxylating) (NADP(+)) 2
  • Mitochondrial NADP(+)-Dependent Malic Enzyme 3 3
  • Malic Enzyme, NADP+-Dependent, Mitochondrial 3
  • Pyruvic-Malic Carboxylase 3
  • Malate Dehydrogenase 3
  • EC 1.1.1 63

External Ids for ME3 Gene

Previous GeneCards Identifiers for ME3 Gene

  • GC11M088478
  • GC11M087691
  • GC11M086374
  • GC11M085878
  • GC11M085829
  • GC11M086152
  • GC11M082440

Summaries for ME3 Gene

Entrez Gene Summary for ME3 Gene

  • Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ME3 Gene

ME3 (Malic Enzyme 3) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include NAD binding and malic enzyme activity. An important paralog of this gene is ME1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ME3 Gene

Genomics for ME3 Gene

Regulatory Elements for ME3 Gene

Enhancers for ME3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ME3 on UCSC Golden Path with GeneCards custom track

Promoters for ME3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ME3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ME3 Gene

86,441,108 bp from pter
86,672,636 bp from pter
231,529 bases
Minus strand

Genomic View for ME3 Gene

Genes around ME3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ME3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ME3 Gene

Proteins for ME3 Gene

  • Protein details for ME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADP-dependent malic enzyme, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B7Z6V0
    • Q8TBJ0

    Protein attributes for ME3 Gene

    604 amino acids
    Molecular mass:
    67068 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ME3 Gene


neXtProt entry for ME3 Gene

Proteomics data for ME3 Gene at MOPED

Post-translational modifications for ME3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ME3 Gene

Protein Domains for ME3 Gene

Suggested Antigen Peptide Sequences for ME3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the malic enzymes family.
  • Belongs to the malic enzymes family.
genes like me logo Genes that share domains with ME3: view

No data available for Gene Families for ME3 Gene

Function for ME3 Gene

Molecular function for ME3 Gene

GENATLAS Biochemistry:
malic enzyme 3, NADP(+)-dependent, mitochondrial,predominantly expressed in tissues with a low division rate,catalyzing the decarboxylation of malate to pyruvate
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
Oxaloacetate = pyruvate + CO(2).

Enzyme Numbers (IUBMB) for ME3 Gene

Gene Ontology (GO) - Molecular Function for ME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA --
GO:0048037 cofactor binding TAS 7818469
genes like me logo Genes that share ontologies with ME3: view
genes like me logo Genes that share phenotypes with ME3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ME3

miRNA for ME3 Gene

miRTarBase miRNAs that target ME3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ME3 Gene

Localization for ME3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ME3 Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for ME3 Gene COMPARTMENTS Subcellular localization image for ME3 gene
Compartment Confidence
mitochondrion 5
cytosol 3
chloroplast 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ME3 Gene

Pathways & Interactions for ME3 Gene

genes like me logo Genes that share pathways with ME3: view

Pathways by source for ME3 Gene

Interacting Proteins for ME3 Gene

Selected Interacting proteins: Q16798-MAON_HUMAN for ME3 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009060 aerobic respiration TAS 7818469
genes like me logo Genes that share ontologies with ME3: view

No data available for SIGNOR curated interactions for ME3 Gene

Drugs & Compounds for ME3 Gene

(7) Drugs for ME3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
tartronate Experimental Pharma Target 0
NADH Nutra Target 0
malic acid Pharma Agonist, Activator 0
Manganese Pharma 32

(7) Additional Compounds for ME3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Hydroxypropanedioic acid
  • 2-Hydroxymalonate
  • 2-Hydroxymalonic acid
  • 2-Hydroxypropanedioic acid
  • 2-Tartronic acid
  • Hydroxy-Malonic acid
L-Malic acid
  • (-)-(S)-Malate
  • (-)-(S)-Malic acid
  • (-)-Hydroxysuccinate
  • (-)-Hydroxysuccinic acid
  • (-)-L-Malic acid
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
genes like me logo Genes that share compounds with ME3: view

Transcripts for ME3 Gene

Unigene Clusters for ME3 Gene

Malic enzyme 3, NADP(+)-dependent, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ME3 Gene

No ASD Table

Relevant External Links for ME3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ME3 Gene

mRNA expression in normal human tissues for ME3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ME3 Gene

This gene is overexpressed in Brain (25.2), Liver (14.8), and Frontal cortex (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ME3 Gene

SOURCE GeneReport for Unigene cluster for ME3 Gene Hs.199743

mRNA Expression by UniProt/SwissProt for ME3 Gene

Tissue specificity: Expressed predominantly in organs with a low-division rate.
genes like me logo Genes that share expression patterns with ME3: view

Protein tissue co-expression partners for ME3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ME3 Gene

Orthologs for ME3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ME3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ME3 35
  • 91.23 (n)
  • 94.7 (a)
ME3 36
  • 93 (a)
(Canis familiaris)
Mammalia ME3 35
  • 92.05 (n)
  • 96.03 (a)
ME3 36
  • 96 (a)
(Mus musculus)
Mammalia Me3 35
  • 89.29 (n)
  • 94.21 (a)
Me3 16
Me3 36
  • 94 (a)
(Pan troglodytes)
Mammalia ME3 35
  • 99.72 (n)
  • 99.5 (a)
ME3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Me3 35
  • 86.82 (n)
  • 90.37 (a)
(Monodelphis domestica)
Mammalia ME3 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia ME3 36
  • 79 (a)
(Gallus gallus)
Aves ME3 35
  • 74.3 (n)
  • 81.04 (a)
ME3 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ME3 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia me3 35
  • 71.5 (n)
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6324 35
(Danio rerio)
Actinopterygii me3 35
  • 72.33 (n)
  • 79.33 (a)
me3 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.326 35
fruit fly
(Drosophila melanogaster)
Insecta CG7848 37
  • 35 (a)
Mdh 37
  • 56 (a)
Men 37
  • 56 (a)
Menl-1 37
  • 45 (a)
Menl-2 37
  • 42 (a)
Men-b 35
  • 58.38 (n)
  • 56.81 (a)
CG7848 36
  • 30 (a)
Men 36
  • 39 (a)
Men-b 36
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004159 35
  • 61.42 (n)
  • 60.29 (a)
(Caenorhabditis elegans)
Secernentea Y48B6A.12 37
  • 54 (a)
men-1 35
  • 58.3 (n)
  • 55.78 (a)
men-1 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAE1 36
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NADP-ME1 35
  • 52.56 (n)
  • 51.12 (a)
(Oryza sativa)
Liliopsida Os01g0743500 35
  • 54.69 (n)
  • 51.58 (a)
(Triticum aestivum)
Liliopsida Ta.14421 35
Species with no ortholog for ME3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ME3 Gene

Gene Tree for ME3 (if available)
Gene Tree for ME3 (if available)

Paralogs for ME3 Gene

Paralogs for ME3 Gene

genes like me logo Genes that share paralogs with ME3: view

Variants for ME3 Gene

Sequence variations from dbSNP and Humsavar for ME3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17856661 - 86,559,754(+) CTGGC(C/T)CAGAA nc-transcript-variant, reference, missense
rs1042780 - 86,450,346(-) ACCAA(C/G)AACAA intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs525764 -- 86,538,625(-) GAGAG(A/G)TGGAA intron-variant
rs530278 -- 86,663,081(+) TTTCA(G/T)GACCA intron-variant
rs531908 -- 86,525,736(+) GGTGC(A/G)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ME3 Gene

Variant ID Type Subtype PubMed ID
nsv898056 CNV Loss 21882294
nsv510265 CNV Loss 20534489
esv267584 CNV Insertion 20981092
esv274960 CNV Gain+Loss 21479260
nsv528182 CNV Loss 19592680
nsv522178 CNV Loss 19592680
nsv471753 CNV Loss 16327809
esv2668174 CNV Deletion 23128226
esv29418 CNV Loss 19812545
esv2744855 CNV Deletion 23290073
esv2662437 CNV Deletion 23128226
esv26643 CNV Loss 19812545
nsv8852 CNV Loss 18304495
dgv231n67 CNV Loss 20364138
dgv232n67 CNV Loss 20364138
nsv471754 CNV Loss 16327809
nsv826020 CNV Loss 20364138
esv4749 CNV Deletion 18987735
nsv819492 CNV Loss 19587683
esv2744856 CNV Deletion 23290073
dgv230e199 CNV Deletion 23128226
nsv898057 CNV Loss 21882294
nsv522823 CNV Loss 19592680
esv2678915 CNV Deletion 23128226
nsv520466 CNV Loss 19592680
esv2672841 CNV Deletion 23128226
nsv428263 CNV Loss 18775914

Variation tolerance for ME3 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ME3 Gene

Disorders for ME3 Gene

Relevant External Links for ME3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ME3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ME3 Gene

Publications for ME3 Gene

  1. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. (PMID: 7818469) Loeber G. … Schwendenwein R. (Biochem. J. 1994) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3

Products for ME3 Gene

Sources for ME3 Gene