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Aliases for ME3 Gene

Aliases for ME3 Gene

  • Malic Enzyme 3, NADP(+)-Dependent, Mitochondrial 2 3
  • EC 4 63
  • NADP-ME 3 4
  • Mitochondrial NADP(+)-Dependent Malic Enzyme 3 3
  • Malic Enzyme, NADP+-Dependent, Mitochondrial 3
  • NADP-Dependent Malic Enzyme, Mitochondrial 3
  • Pyruvic-Malic Carboxylase 3
  • Malate Dehydrogenase 3
  • Malic Enzyme 3 4
  • EC 1.1.1 63

External Ids for ME3 Gene

Previous GeneCards Identifiers for ME3 Gene

  • GC11M088478
  • GC11M087691
  • GC11M086374
  • GC11M085878
  • GC11M085829
  • GC11M086152
  • GC11M082440

Summaries for ME3 Gene

Entrez Gene Summary for ME3 Gene

  • Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ME3 Gene

ME3 (Malic Enzyme 3, NADP(+)-Dependent, Mitochondrial) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include NAD binding and malic enzyme activity. An important paralog of this gene is ME1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ME3 Gene

Genomics for ME3 Gene

Regulatory Elements for ME3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ME3 Gene

86,441,108 bp from pter
86,672,636 bp from pter
231,529 bases
Minus strand

Genomic View for ME3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ME3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ME3 Gene

Proteins for ME3 Gene

  • Protein details for ME3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADP-dependent malic enzyme, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B7Z6V0
    • Q8TBJ0

    Protein attributes for ME3 Gene

    604 amino acids
    Molecular mass:
    67068 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal cations. Prefers magnesium or manganese.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ME3 Gene


neXtProt entry for ME3 Gene

Proteomics data for ME3 Gene at MOPED

Post-translational modifications for ME3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ME3 Gene

Protein Domains for ME3 Gene

Suggested Antigen Peptide Sequences for ME3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the malic enzymes family.
  • Belongs to the malic enzymes family.
genes like me logo Genes that share domains with ME3: view

No data available for Gene Families for ME3 Gene

Function for ME3 Gene

Molecular function for ME3 Gene

GENATLAS Biochemistry:
malic enzyme 3, NADP(+)-dependent, mitochondrial,predominantly expressed in tissues with a low division rate,catalyzing the decarboxylation of malate to pyruvate
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH
UniProtKB/Swiss-Prot CatalyticActivity:
Oxaloacetate = pyruvate + CO(2)

Enzyme Numbers (IUBMB) for ME3 Gene

Gene Ontology (GO) - Molecular Function for ME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004470 malic enzyme activity IDA 7818469
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA --
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity IDA 7818469
GO:0008948 oxaloacetate decarboxylase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ME3: view

Animal Model Products

miRNA for ME3 Gene

miRTarBase miRNAs that target ME3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ME3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ME3 Gene

Localization for ME3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ME3 Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for ME3 Gene COMPARTMENTS Subcellular localization image for ME3 gene
Compartment Confidence
mitochondrion 5
chloroplast 2
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 7818469
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with ME3: view

Pathways for ME3 Gene

genes like me logo Genes that share pathways with ME3: view

Pathways by source for ME3 Gene

Interacting Proteins for ME3 Gene

Selected Interacting proteins: Q16798-MAON_HUMAN for ME3 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ME3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process IDA 7818469
GO:0006108 malate metabolic process IDA 7818469
GO:0009060 aerobic respiration TAS 7818469
GO:0055114 oxidation-reduction process IDA 7818469
GO:0072592 oxygen metabolic process TAS 7818469
genes like me logo Genes that share ontologies with ME3: view

Drugs for ME3 Gene

(2) Drugbank Compounds for ME3 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
44 Target experimental
  • 1,4-dihydronicotinamide adenine dinucleotide
606-68-8 439153 Target nutraceutical

(13) HMDB Compounds for ME3 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
Hydrogen Ion
  • Hydrogen cation
Hydroxypropanedioic acid
  • 2-Hydroxymalonate
L-Malic acid
  • (-)-(S)-Malate
  • Magnesium
genes like me logo Genes that share compounds with ME3: view

Transcripts for ME3 Gene

Unigene Clusters for ME3 Gene

Malic enzyme 3, NADP(+)-dependent, mitochondrial:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ME3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ME3 Gene

No ASD Table

Relevant External Links for ME3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ME3 Gene

mRNA expression in normal human tissues for ME3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ME3 Gene

This gene is overexpressed in Brain (25.2), Liver (14.8), and Frontal cortex (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ME3 Gene

SOURCE GeneReport for Unigene cluster for ME3 Gene Hs.199743

mRNA Expression by UniProt/SwissProt for ME3 Gene

Tissue specificity: Expressed predominantly in organs with a low-division rate
genes like me logo Genes that share expressions with ME3: view

Expression partners for ME3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ME3 Gene

Orthologs for ME3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ME3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ME3 35
  • 91.23 (n)
  • 94.7 (a)
ME3 36
  • 93 (a)
(Canis familiaris)
Mammalia ME3 35
  • 92.05 (n)
  • 96.03 (a)
ME3 36
  • 96 (a)
(Mus musculus)
Mammalia Me3 35
  • 89.29 (n)
  • 94.21 (a)
Me3 16
Me3 36
  • 94 (a)
(Pan troglodytes)
Mammalia ME3 35
  • 99.72 (n)
  • 99.5 (a)
ME3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Me3 35
  • 86.82 (n)
  • 90.37 (a)
(Monodelphis domestica)
Mammalia ME3 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia ME3 36
  • 79 (a)
(Gallus gallus)
Aves ME3 35
  • 74.3 (n)
  • 81.04 (a)
ME3 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ME3 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia me3 35
  • 71.5 (n)
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6324 35
(Danio rerio)
Actinopterygii me3 35
  • 72.33 (n)
  • 79.33 (a)
me3 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.326 35
fruit fly
(Drosophila melanogaster)
Insecta CG7848 37
  • 35 (a)
Mdh 37
  • 56 (a)
Men 37
  • 56 (a)
Menl-1 37
  • 45 (a)
Menl-2 37
  • 42 (a)
Men-b 35
  • 58.38 (n)
  • 56.81 (a)
CG7848 36
  • 30 (a)
Men 36
  • 39 (a)
Men-b 36
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004159 35
  • 61.42 (n)
  • 60.29 (a)
(Caenorhabditis elegans)
Secernentea Y48B6A.12 37
  • 54 (a)
men-1 35
  • 58.3 (n)
  • 55.78 (a)
men-1 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAE1 36
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NADP-ME1 35
  • 52.56 (n)
  • 51.12 (a)
(Oryza sativa)
Liliopsida Os01g0743500 35
  • 54.69 (n)
  • 51.58 (a)
(Triticum aestivum)
Liliopsida Ta.14421 35
Species with no ortholog for ME3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ME3 Gene

Gene Tree for ME3 (if available)
Gene Tree for ME3 (if available)

Paralogs for ME3 Gene

Paralogs for ME3 Gene

genes like me logo Genes that share paralogs with ME3: view

Variants for ME3 Gene

Sequence variations from dbSNP and Humsavar for ME3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7548 -- 86,442,869(-) CTCTA(C/T)CCACC reference, synonymous-codon
rs15926 -- 86,447,141(-) CGAGC(G/T)CCCTA reference, missense
rs147045 -- 86,479,382(-) TACTT(C/G)AGAGT intron-variant
rs471780 -- 86,646,492(-) taatc(C/T)tgtct intron-variant
rs480290 -- 86,644,154(-) gcCCC(A/C)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ME3 Gene

Variant ID Type Subtype PubMed ID
nsv898056 CNV Loss 21882294
nsv510265 CNV Loss 20534489
esv267584 CNV Insertion 20981092
esv274960 CNV Gain+Loss 21479260
nsv528182 CNV Loss 19592680
nsv522178 CNV Loss 19592680
nsv471753 CNV Loss 16327809
esv2668174 CNV Deletion 23128226
esv29418 CNV Loss 19812545
esv2744855 CNV Deletion 23290073
esv2662437 CNV Deletion 23128226
esv26643 CNV Loss 19812545
nsv8852 CNV Loss 18304495
dgv231n67 CNV Loss 20364138
dgv232n67 CNV Loss 20364138
nsv471754 CNV Loss 16327809
nsv826020 CNV Loss 20364138
esv4749 CNV Deletion 18987735
nsv819492 CNV Loss 19587683
esv2744856 CNV Deletion 23290073
dgv230e199 CNV Deletion 23128226
nsv898057 CNV Loss 21882294
nsv522823 CNV Loss 19592680
esv2678915 CNV Deletion 23128226
nsv520466 CNV Loss 19592680
esv2672841 CNV Deletion 23128226
nsv428263 CNV Loss 18775914

Relevant External Links for ME3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ME3 Gene

Disorders for ME3 Gene

Relevant External Links for ME3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ME3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ME3 Gene

Publications for ME3 Gene

  1. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. (PMID: 7818469) Loeber G. … Schwendenwein R. (Biochem. J. 1994) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for ME3 Gene

Sources for ME3 Gene

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