Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ME3 Gene

protein-coding   GIFtS: 59
GCID: GC11M086152

Malic Enzyme 3, NADP(+)-Dependent, Mitochondrial

  Search for ME3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Malic Enzyme 3, NADP(+)-Dependent, Mitochondrial1 2     Mitochondrial NADP(+)-Dependent Malic Enzyme 32
NADP-ME2 3     NADP-Dependent Malic Enzyme, Mitochondrial2
EC 1.1.1.403 8     Pyruvic-Malic Carboxylase2
Malate Dehydrogenase2     Malic Enzyme 33
Malic Enzyme, NADP+-Dependent, Mitochondrial2     EC 1.1.18

External Ids:    HGNC: 69851   Entrez Gene: 108732   Ensembl: ENSG000001513767   OMIM: 6046265   UniProtKB: Q167983   

Export aliases for ME3 gene to outside databases

Previous GC identifers: GC11M088478 GC11M087691 GC11M086374 GC11M085878 GC11M085829 GC11M082440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ME3 Gene:
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a
cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a
mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a
mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for
this gene, but the biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ME3 Gene:
ME3 (malic enzyme 3, NADP(+)-dependent, mitochondrial) is a protein-coding gene. GO annotations related to this gene include NAD binding and malic enzyme activity. An important paralog of this gene is ME2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ME3 gene promoter:
         IRF-2   Tal-1   POU3F2 (N-Oct-5a)   POU3F2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidME3 promoter sequence
   Search Chromatin IP Primers for ME3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ME3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11cen-q22.3   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

ME3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ME3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M086152:  view genomic region     (about GC identifiers)

Start:
86,152,150 bp from pter      End:
86,383,678 bp from pter
Size:
231,529 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MAON_HUMAN, Q16798 (See protein sequence)
Recommended Name: NADP-dependent malic enzyme, mitochondrial precursor  
Size: 604 amino acids; 67068 Da
Cofactor: Divalent metal cations. Prefers magnesium or manganese (By similarity)
Secondary accessions: Q8TBJ0

Explore the universe of human proteins at neXtProt for ME3: NX_Q16798

Explore proteomics data for ME3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ME3 (Q16798) (see all 20)
     VYTPTVG  FASGSPF  DVGTNNE  AFTEQIL 


    See ME3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001014811.1  NP_006671.2  NP_001155058.1  

    ENSEMBL proteins: 
     ENSP00000376998   ENSP00000431182   ENSP00000433636   ENSP00000434690   ENSP00000435427  
     ENSP00000437204   ENSP00000434431   ENSP00000352657   ENSP00000440246   ENSP00000315255  

    ME3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ME3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ME3
    GenScript Custom Purified and Recombinant Proteins Services for ME3
    Novus Biologicals ME3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ME3

     
    Search eBioscience for Proteins for ME3 

    ME3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ME3
    OriGene Custom Antibody Services for ME3
    Novus Biologicals ME3 Antibodies
    Search for Antibodies for ME3 at Abcam
    Cloud-Clone Corp. Antibodies for ME3
    Search ThermoFisher Antibodies for ME3
    LSBio Antibodies in human, mouse, rat for ME3

    ME3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ME3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ME3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ME3
    Cloud-Clone Corp. CLIAs for ME3
    Search eBioscience for ELISAs for ME3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR012301 Malic_N_dom
     IPR012302 Malic_NAD-bd
     IPR015884 Malic_enzyme_CS
     IPR001891 Malic_OxRdtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q16798

    ProtoNet protein and cluster: Q16798

    1 Blocks protein domain: IPB001891 Malic oxidoreductase

    UniProtKB/Swiss-Prot: MAON_HUMAN, Q16798
    Similarity: Belongs to the malic enzymes family


    Find genes that share domains with ME3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAON_HUMAN, Q16798
    Catalytic activity: (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH
    Catalytic activity: Oxaloacetate = pyruvate + CO(2)

         Genatlas biochemistry entry for ME3:
    malic enzyme 3, NADP(+)-dependent, mitochondrial,predominantly expressed in tissues with a low division
    rate,catalyzing the decarboxylation of malate to pyruvate

         Enzyme Numbers (IUBMB): EC 1.1.1.401 2 EC 1.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004470malic enzyme activity IDA7818469
    GO:0004471malate dehydrogenase (decarboxylating) (NAD+) activity IEA--
    GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity IDA7818469
    GO:0008948oxaloacetate decarboxylase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ME3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ME3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ME3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ME3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ME3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ME3:
    hsa-mir-30a-5p (MIRT028648)

    Block miRNA regulation of human, mouse, rat ME3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ME3
    SwitchGear 3'UTR luciferase reporter plasmidME3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ME3
    Predesigned siRNA for gene silencing in human, mouse, rat ME3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ME3

    Clone
    Products:
         
    OriGene clones in human, mouse for ME3 (see all 16)
    OriGene ORF clones in mouse, rat for ME3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ME3 (NM_002513)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ME3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ME3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ME3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ME3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MAON_HUMAN, Q16798: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS7818469
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with ME3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ME3 About    
    See pathways by source

    SuperPathContained pathways About
    1Carbon metabolism
    Carbon metabolism0.38
    2Metabolism
    Metabolic pathways0.38
    3Pyruvate metabolism
    Pyruvate metabolism


    Find genes that share SuperPaths with ME3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Kegg Pathways  (Kegg details for ME3):
        Pyruvate metabolism
    Metabolic pathways
    Carbon metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ME3
    Interactions:

        Search GeneGlobe Interaction Network for ME3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ME3 (Q167983 ENSP000003526574) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKBP122773I2D: score=4 
    PDHBENSP000003072414STRING: ENSP00000307241
    PKLRENSP000003399334STRING: ENSP00000339933
    PKMENSP000003201714STRING: ENSP00000320171
    LDHDENSP000003000514STRING: ENSP00000300051
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process IDA7818469
    GO:0006108malate metabolic process IDA7818469
    GO:0009060aerobic respiration TAS7818469
    GO:0055114oxidation-reduction process IDA7818469
    GO:0072592oxygen metabolic process TAS7818469

    Find genes that share ontologies with ME3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ME3 (MAON)

    10 HMDB Compounds for ME3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    L-Malic acid(-)-(S)-Malate (see all 27)97-67-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Malic acid2-Hydroxybutanedioic acid (see all 24)6915-15-7--
    Manganesemanganese 7439-96-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    3 DrugBank Compounds for ME3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17080607 16740313 17603759
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235
    Tartronate-- --target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ME3 gene (3 alternative transcripts): 
    NM_001014811.1  NM_006680.2  NM_001161586.1  

    Unigene Cluster for ME3:

    Malic enzyme 3, NADP(+)-dependent, mitochondrial
    Hs.199743  [show with all ESTs]
    Unigene Representative Sequence: NM_001161586
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393324(uc001pbz.3) ENST00000524826 ENST00000530520 ENST00000526504(uc010rtr.1)
    ENST00000525957 ENST00000530335 ENST00000534638 ENST00000532471 ENST00000526834
    ENST00000526944 ENST00000359636(uc001pca.3) ENST00000543262(uc009yvk.3)
    ENST00000323418
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ME3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ME3
    SwitchGear 3'UTR luciferase reporter plasmidME3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ME3
    Predesigned siRNA for gene silencing in human, mouse, rat ME3
    Clone
    Products:
         
    OriGene clones in human, mouse for ME3 (see all 16)
    OriGene ORF clones in mouse, rat for ME3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ME3 (NM_002513)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ME3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ME3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ME3
    OriGene qSTAR qPCR primer pairs in human, mouse for ME3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ME3
      QuantiTect SYBR Green Assays in human, mouse, rat ME3
      QuantiFast Probe-based Assays in human, mouse, rat ME3

    Additional mRNA sequence: 

    AK092181.1 AK300974.1 AK313695.1 AY424278.1 BC022472.2 X79440.1 

    17 DOTS entries:

    DT.102828818  DT.451469  DT.451443  DT.75102420  DT.75184418  DT.97842348  DT.108321  DT.75130260 
    DT.86853011  DT.100021624  DT.120735142  DT.100782908  DT.100782909  DT.40285888  DT.97842347  DT.91844743 
    DT.99935893 

    Selected AceView cDNA sequences (see all 133):

    BM787648 BM665443 CB132135 BQ882896 BM354089 BX646131 AI743966 CD514548 
    BX369939 AA132644 AI088692 BE503563 AU139491 CB851088 BF062610 AA350296 
    CK820058 BF476121 BU687977 AI624172 AV704142 BU154711 BG818773 CK820057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ME3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTTCAGA
    ME3 Expression
    About this image


    ME3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    ME3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ME3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199743

    UniProtKB/Swiss-Prot: MAON_HUMAN, Q16798
    Tissue specificity: Expressed predominantly in organs with a low-division rate

        Custom PCR Arrays for ME3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ME3
    OriGene qSTAR qPCR primer pairs in human, mouse for ME3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ME3
    QuantiTect SYBR Green Assays in human, mouse, rat ME3
    QuantiFast Probe-based Assays in human, mouse, rat ME3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ME3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ME3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Me31 , 5 malic enzyme 3, NADP(+)-dependent, mitochondrial1, 5 89.29(n)1
    94.21(a)1
      7 (50.27 cM)5
    1092641  NM_181407.41  NP_852072.21 
     896323925 
    chicken
    (Gallus gallus)
    Aves ME31 malic enzyme 3, NADP(+)-dependent, mitochondrial 74.3(n)
    81.04(a)
      419019  XM_003640570.2  XP_003640618.2 
    lizard
    (Anolis carolinensis)
    Reptilia ME36
    malic enzyme 3, NADP(+)-dependent, mitochondrial
    77(a)
    1 ↔ 1
    3(200211728-200347842)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.63242 Xenopus laevis transcribed sequence with weak similarity more 75.81(n)    BQ897346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA474606.12   -- 74.4(n)    CA474606.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Men3
    Men-b1
    malate dehydrogenase (oxaloacetate
    decarboxylating) more3
    Malic enzyme b1
    56(a)
    (best of 5)3
    58.38(n)1
    56.81(a)1
      439361  NM_143702.31  NP_651959.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48B6A.123
    men-11
    men-11 54(a)3
    58.3(n)1
    55.78(a)1
      II(14226477-14233689)3
    1750791  NM_064567.41  NP_496968.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAE16
    Mitochondrial malic enzyme, catalyzes the oxidativ...
    29(a)
    1 → many
    XI(382716-384725) YKL029C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NADP-ME11 NADP-ME1 52.56(n)
    51.12(a)
      816509  NM_127548.3  NP_179580.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07435001 Os01g0743500 54.69(n)
    51.58(a)
      4326552  NM_001050754.1  NP_001044219.1 


    ENSEMBL Gene Tree for ME3 (if available)
    TreeFam Gene Tree for ME3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ME3 gene
    ME22  ME12  
    Selected SIMAP similar genes for ME3 using alignment to 10 protein entries:     MAON_HUMAN (see all proteins) (see all similar genes):
    ME1    PCDHGA10    PCDHGA1    ME2    PCDHGA6    PCDHB11
    PCDHGA3    ME6    DKFZp586I1919    PCDHB7    ME4    PCDHB2
    PCDHB3    PCDHGB1    PCDHB6    PCDHB9    PCDHB14    PCDHGC4

    Find genes that share paralogs with ME3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ME3 (see all 5171)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs718815861,2
    C--82475456(+) TATAT-/AGAG  
            
    AGAGA
    3 -- int10--------
    rs122947561,2
    C,F,H--86151721(+) CACTGC/TCGAGA 3 -- ds5001 int19Minor allele frequency- T:0.11NS EA NA CSA WA 637
    rs1381668341,2
    --86151821(+) TCCCC-/ATGACT
            
    CCCAC
    3 -- ds5001 int10--------
    rs1885091661,2
    --86151834(+) CACCCA/GTCTTT 3 -- int1 ds50010--------
    rs783547211,2
    F--86151889(+) TCTTAC/TATTTC 3 -- ds5001 int11Minor allele frequency- T:0.03NA 120
    rs122816451,2
    C,F,H--86151931(+) CCCTCA/TGTTTT 3 -- ds5001 int110Minor allele frequency- T:0.11NS EA NA CSA WA 783
    rs122830351,2
    C,F,H--86151995(+) GTCCAA/GTCTCC 3 -- ds5001 int113Minor allele frequency- G:0.12NS EA NA CSA WA 925
    rs1164650091,2
    F--86152081(+) TTGGTG/AATTAA 3 -- ds5001 int11Minor allele frequency- A:0.03WA 118
    rs769124991,2
    C,F--86152192(+) ATCTCC/TTCTCA 3 -- ut311Minor allele frequency- T:0.17WA 118
    rs1808865111,2
    --86152241(+) TTCACC/TTGGGC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ME3 (86152150 - 86383678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ME3 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672841CNV Deletion23128226
    dgv230e199CNV Deletion23128226
    esv2662437CNV Deletion23128226
    esv4749CNV Deletion18987735
    esv2668174CNV Deletion23128226
    esv2744855CNV Deletion23290073
    esv2678915CNV Deletion23128226
    esv2744856CNV Deletion23290073
    esv267584CNV Insertion20981092
    nsv510265CNV Loss20534489

    Human Gene Mutation Database (HGMD): ME3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ME3
    DNA2.0 Custom Variant and Variant Library Synthesis for ME3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604626    OMIM disorders: --


    Find genes that share disorders with ME3           About GenesLikeMe

    Genetic Association Database (GAD): ME3
    Human Genome Epidemiology (HuGE) Navigator: ME3 (4 documents)

    Export disorders for ME3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ME3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ME3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. (PubMed id 7818469)1, 2, 3 Loeber G.... Schwendenwein R. (Biochem. J. 1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PubMed id 24025145)1 Chung S....Nakamura Y. (Breast Cancer Res. 2013)
    6. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    7. Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. (PubMed id 20471030)1 Martins-de-Souza D....Turck C.W. (J Psychiatr Res 2010)
    8. Functional roles of the tetramer organization of malic enzyme. (PubMed id 19416979)1 Hsieh J.Y....Hung H.C. (J. Biol. Chem. 2009)
    9. Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme. (PubMed id 19236308)1 Hsieh J.Y....Hung H.C. (Biochem. J. 2009)
    10. Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of the nucleotide binding site Lys346. (PubMed id 18959763)1 Hsieh J.Y....Hung H.C. (FEBS J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10873 HGNC: 6985 AceView: ME3 Ensembl:ENSG00000151376 euGenes: HUgn10873
    ECgene: ME3 Kegg: 10873 H-InvDB: ME3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ME3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ME3 gene:
    Search GeneIP for patents involving ME3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ME3   OriGene RNAi products in human, mouse, rat for ME3  
     OriGene qPCR primer pairs and template standards for ME3   OriGene Protein Over-expression Lysate for ME3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ME3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ME3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ME3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ME3   OriGene Custom Protein Services for ME3  

     
     
     Block miRNA regulation of human, mouse, rat ME3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ME3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ME3 Predesigned siRNA for gene silencing in human, mouse, rat ME3
     QuantiFast Probe-based Assays in human, mouse, rat ME3 QuantiTect SYBR Green Assays in human, mouse, rat ME3
     Custom PCR Arrays for ME3 Search Chromatin IP Primers for ME3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ME3  Search GeneGlobe Interaction Network for ME3
     Regulatory tfbs in ME3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ME3 GenScript cDNA clones with any tag delivered in your preferred vector for ME3
     GenScript Custom Assay Services for ME3 GenScript Custom overexpressing Cell Line Services for ME3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ME3 (MAON)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ME3 antibodies
     ME3 lysates
     Search for Antibodies for ME3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ME3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ME3
     Antibodies for ME3
     ELISAs for ME3
     CLIAs for ME3



     Browse ESI BIO Cell Lines and PureStem Progenitors for ME3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ME3
     SwitchGear 3'UTR luciferase reporter plasmids for ME3
     SwitchGear Promoter luciferase reporter plasmids for ME3
     Search ThermoFisher Antibodies for ME3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ME3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ME3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ME3
     LSBio Antibodies in human, mouse, rat for ME3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ME3
      Search eBioscience for proteins for ME3
      Search eBioscience for elisas for ME3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ME3 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4