Aliases for ME2 Gene
External Ids for ME2 Gene
Previous GeneCards Identifiers for ME2 Gene
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]
GeneCards Summary for ME2 Gene
ME2 (Malic Enzyme 2) is a Protein Coding gene. Diseases associated with ME2 include Idiopathic Generalized Epilepsy and Generalized Epilepsy With Febrile Seizures Plus. Among its related pathways are Pyruvate metabolism and Carbon metabolism. GO annotations related to this gene include electron carrier activity and malic enzyme activity. An important paralog of this gene is ME3.