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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ME2 Gene

protein-coding GIFtS: 64
GCID: GC18P048405

malic enzyme 2, NAD(+)-dependent, mitochondrial

Explore 15 diseases affiliated with
ME2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Malic Enzyme 2, NAD(+)-Dependent, Mitochondrial¹ ²		Pyruvic-Malic Carboxylase²
NAD-ME² ³		EC 1.1.1.38³
ODS1² ⁵		Malic Enzyme 2³
Malate Dehydrogenase²		EC 1.1.1⁸
NAD-Dependent Malic Enzyme, Mitochondrial²

External Ids:	HGNC: 6984¹	Entrez Gene: 4200²	Ensembl: ENSG00000082212⁷	OMIM: 154270⁵	UniProtKB: P23368³

Export aliases for ME2 gene to outside databases

Previous GC identifers: GC18P048588 GC18P048341 GC18P046657 GC18P046659 GC18P045260

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ME2:

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative

decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia

that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide

polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy.

Alternatively spliced transcript variants encoding different isoforms found for this gene. (provided by RefSeq, Dec

2009)

Gene Wiki entry for ME2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010966.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ME2 gene promoter:
AP-1 ATF-2 POU6F1 (c2) POU2F1 POU2F1a HSF2 FOXO1a Cart-1 c-Jun FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ME2 promoter sequence

Search SABiosciences Chromatin IP Primers for ME2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ME2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21 Ensembl cytogenetic band: 18q21.2 HGNC cytogenetic band: 18q21

ME2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ME2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P048405: view genomic region (about GC identifiers)

Start:	48,405,419 bp from pter	End:	48,476,165 bp from pter
Size:	70,747 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAOM_HUMAN, P23368 (See protein sequence)

Recommended Name: NAD-dependent malic enzyme, mitochondrial precursor

Size: 584 amino acids; 65444 Da

Cofactor: Divalent metal cations. Prefers magnesium or manganese

Subunit: Homotetramer

Subcellular location: Mitochondrion matrix

Miscellaneous: This isoenzyme can also use NADP(+) but is more effective with NAD(+)

6/10 PDB 3D structures from and Proteopedia for ME2 (see all 10):

1DO8 (3D)

1EFK (3D)

1EFL (3D)

1GZ3 (3D)

1GZ4 (3D)

1PJ2 (3D)

Secondary accessions: B2R8J2 Q9BWL6 Q9BYG1 Q9H4B2

Alternative splicing: 2 isoforms: P23368-1 P23368-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ME2: NX_P23368

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23368

4/12 DME Specific Peptides for ME2 (P23368) (see all 12)

VYTPTVG

FASGSPF

GIPVGKL

RNEKLFY

ME2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001161807.1 NP_002387.1

ENSEMBL proteins:

ENSP00000321070 ENSP00000372384

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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--
GO:0005759	mitochondrial matrix	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

ME2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ME2 for domains About GeneDecksing

5 InterPro domains/families:

IPR012301 Malic_N

IPR012302 Malic_NAD-bd

IPR015884 Malic_enzyme_CS

IPR001891 Malic_OxRdtase

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry P23368

ProtoNet protein and cluster: P23368

1 Blocks protein family: IPB001891 Malic oxidoreductase

UniProtKB/Swiss-Prot: MAOM_HUMAN, P23368

Similarity: Belongs to the malic enzymes family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MAOM_HUMAN, P23368

Catalytic activity: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH

Catalytic activity: Oxaloacetate = pyruvate + CO(2)

Enzyme regulation: Subject to allosteric activation by fumarate

Genatlas biochemistry entry for ME2:

malic enzyme 2,mitochondrial

Enzyme Numbers (IUBMB): EC 1.1.1.38¹ EC 1.1.1²

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Gene Editing
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In Situ Assay
Products:

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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004471	malate dehydrogenase (decarboxylating) activity	TAS	1993674
GO:0009055	electron carrier activity	TAS	1993674
GO:0016619	malate dehydrogenase (oxaloacetate-decarboxylating) activity	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0051287	NAD binding	IEA	--

ME2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ME2:

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Pyruvate metabolism

Pyruvate metabolism

1.00

gluconeogenesis I

gluconeogenesis I

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ME2

gluconeogenesis I

1 Kegg Pathway (Kegg details for ME2):

Pyruvate metabolism

ME2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ME2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/256 Interacting proteins for ME2 (P23368^{2, 3} ENSP00000321070⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 256)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
ATIC	P31939³, ENSP00000236959⁴	I2D: score=1 STRING: ENSP00000236959
USP15	Q9Y4E8³, ENSP00000258123⁴	I2D: score=1 STRING: ENSP00000258123
WNK1	Q9H4A3³, ENSP00000313059⁴	I2D: score=1 STRING: ENSP00000313059
RAB11A	P62491³, ENSP00000261890⁴	I2D: score=1 STRING: ENSP00000261890

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006108	malate metabolic process	IEA	--

ME2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ME2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ME2

10 HMDB Compounds for ME2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
L-Malic acid	(-)-(S)-Malate (see all 27)	97-67-6	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Malic acid	2-Hydroxybutanedioic acid (see all 24)	6915-15-7	--
Manganese	manganese	7439-96-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Pyruvic acid	2-Oxopropanoate (see all 14)	127-17-3	--

6 DrugBank Compounds for ME2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-Ketomalonic Acid	--	--	target	--	17139284 17016423
Fumarate	--	110-17-8	target	--	17139284 17016423
Malate Ion	--	--	target	--	17139284 17016423
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17139284 17016423
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	17139284 17016423
Tartronate	--	--	target	--	17139284 17016423

8 Novoseek chemical compound relationships for ME2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fumarate	76	4	12911313 (1), 14596586 (1), 19691144 (1), 7496989 (1)
malate	74.9	6	7496989 (2), 17258816 (1), 11401430 (1), 15532013 (1) (see all 5)
oxaloacetate	61.2	1	7757881 (1)
pyruvate	56.9	3	11696011 (1), 7757881 (1), 15532013 (1)
atp	36.1	5	15182181 (3), 14596586 (1), 19691144 (1)
nadh	31.9	1	12853453 (1)
gaba	19.9	3	17258816 (1), 15532013 (1)
magnesium	18.9	1	12853453 (1)

Search CenterWatch for drugs/clinical trials and news about ME2 / MAOM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ME2 gene (2 alternative transcripts):

NM_001168335.1 NM_002396.4

Unigene Cluster for ME2:

Malic enzyme 2, NAD(+)-dependent, mitochondrial

Hs.233119 [show with all ESTs]

Unigene Representative Sequence: NM_002396

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000321341 ENST00000382927(uc002ley.3 uc010dpd.3) ENST00000589330

ENST00000585680 ENST00000591925

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		hsa-miR-668 hsa-miR-513a-3p hsa-miR-1271 hsa-miR-570 hsa-miR-23b* hsa-miR-1276 hsa-miR-182 hsa-miR-654-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ME2 3' UTR sequence

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Additional cDNA sequence:

AJ294818.1 AK313391.1 BC000147.1 M55905.1

9 DOTS entries:

DT.92433295 DT.117136 DT.100819457 DT.102819816 DT.100715743 DT.100721863 DT.100819453 DT.100819455

DT.95271673

24/204 AceView cDNA sequences (see all 204):

T17473 BU620212 CB114592 BQ227035 AA496055 BQ029927 AA883256 BM466026

AL044683 AI432514 CB161114 CN481335 AW589736 CK430435 CN481531 AW503701

BU753280 AU185235 CD108441 BI089765 AI218090 BI762261 AA887922 AA826095

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ME2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	·	16c
SP1:													-
SP2:													-																						-		-
SP3:
SP4:																																			-

ECgene alternative splicing isoforms for ME2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ME2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTCTCCACA

About this image

ME2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Rostral Skull Membranous Bones

Bone

Thoracic Rib

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See ME2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ME2

SOURCE GeneReport for Unigene cluster: Hs.233119

SABiosciences Custom PCR Arrays for ME2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ME2 gene from 7/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ME2⁶	--	82(a)	1 ↔ 1	Un(27351040-27357252)
lizard (Anolis carolinensis)	Reptilia	-- --	--	80(a) 65(a)	1 ↔ many 1 ↔ many	GL343471.1(440736-458596) GL343386.1(404715-407567)
African clawed frog (Xenopus laevis)	Amphibia	me2²	malic enzyme 2	76.96(n)		AY225508.1
zebrafish (Danio rerio)	Actinopterygii	me2¹	malic enzyme 2, NAD(+)-dependent, mitochondrial	66.21(n) 75.52(a)		445233 NM_001003627.2 NP_001003627.2
thale cress (Arabidopsis thaliana)	eudicotyledons	NADP-ME3¹	malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)	56.07(n) 51.59(a)		832657 NM_122489.2 NP_197960.1
rice (Oryza sativa)	Liliopsida	Os01g0723400¹	hypothetical protein	56.31(n) 50.95(a)		4324717 NM_001050642.1 NP_001044107.1
E. coli (Escherichia coli)	Gamma proteobacteria	maeA⁶ maeB⁶	malate dehydrogenase, (decarboxylating, NAD-requir... fused malic enzyme predicted oxidoreductase/predic...	39(a) 12(a)	possible ortholog possible ortholog	Chromosome(1551996-1553693) Chromosome(2574120-2576399)

ENSEMBL Gene Tree for ME2 (if available)
TreeFam Gene Tree for ME2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ME2 gene

ME3² ME1²

18/46 SIMAP similar genes for ME2 using alignment to 2 protein entries: MAOM_HUMAN (see all proteins) (see all similar genes):

PCDHB11 PCDHB12 ME1 PCDHB3 PCDHB8 ME3

PCDHB14 PCDHB6 DKFZp586I1919 PCDHB7 ME4 PCDHB2

PCDHB9 PCDHAC2 PCDHA3 PCDHGA1 PCDHGA10 PCDHA13

ME2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ME2
PGOHUM00000235999

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138508545^1,2		--	48403472(+)	`GGAAAG/TAAATT`	2	--	us2k¹		0	--	--	--	--
rs141575229^1,2		--	48403497(+)	`CCAGAA/GAACAG`	2	--	us2k¹		0	--	--	--	--
rs187669348^1,2		--	48403541(+)	`AATAAA/GGAATA`	2	--	us2k¹		0	--	--	--	--
rs2850542^1,2	C,F,A,H,	--	48403560(-)	`GCTTAA/CATTGA`	2	--	us2k¹		23		NS EA NA WA CSA	2337
rs192060862^1,2		--	48403574(+)	`ATAAGC/TTCCCT`	2	--	us2k¹		0	--	--	--	--
rs146212543^1,2		--	48403612(+)	`CTGGGA/CTTATT`	2	--	us2k¹		0	--	--	--	--
rs137951661^1,2		--	48403724(+)	`GGGAGA/GCCGAA`	2	--	us2k¹		0	--	--	--	--
rs183514225^1,2		--	48403897(+)	`GGCGGA/GGGTTT`	2	--	us2k¹		0	--	--	--	--
rs674488^1,2	C,F,	--	48403967(-)	`TTTTTC/ATTTCG`	2	--	us2k¹ trp³		6		NA WA EA	364
rs674044^1,2	C,F,A,	--	48404066(-)	`ATAAGC/TATGTA`	2	--	us2k¹		8		NA WA EA	370

HapMap Linkage Disequilibrium report for ME2 (48405419 - 48476165 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ME2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ME2 for disorders           About GeneDecksing

OMIM gene information: 154270
OMIM disorders: 600669  610064
15 diseases for ME2:    About MalaCards

idiopathic generalized epilepsy friedreich ataxia generalized epilepsy ataxia

psychotic disorder fascioliasis insulinoma alzheimer's disease

breast cancer tuberculosis thyroiditis pancreatitis

leukemia neuronitis mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for ME2:

Idiopathic generalized epilepsy

3 Novoseek disease relationships for ME2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
epilepsy, idiopathic generalized	73.1	3	16190936 (1), 15532013 (1)
epilepsy generalized	69.5	4	16049035 (1), 16278970 (1)
tumors	0	1	1761063 (1)

Genetic Association Database (GAD): ME2
Human Genome Epidemiology (HuGE) Navigator: ME2 (9 documents)

Export disorders for ME2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ME2 gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with ME2)

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world of online information

Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli. (PubMed id 1993674)^{1, 2, 3} Loeber G.... Dworkin M.B. (1991)
Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. (PubMed id 16190936)^{1, 4, 9} Lenzen K.P....Sander T. (2005)
Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. (PubMed id 11401430)^{1, 2, 9} Yanaihara N.... Yokota J. (2001)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism. (PubMed id 12962632)^{1, 2} Tao X.... Tong L. (2003)
Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate. (PubMed id 12121650)^{1, 2} Yang Z.... Tong L. (2002)
Structure of a closed form of human malic enzyme and implications for catalytic mechanism. (PubMed id 10700286)^{1, 2} Yang Z.... Tong L. (2000)
Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases. (PubMed id 10467136)^{1, 2} Xu Y.... Tong L. (1999)
Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells. (PubMed id 19691144)^{1, 9} MacDonald M.J....Kendrick M.A. (2009)
Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. (PubMed id 15532013)^{1, 9} Greenberg D.A....Kang H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4200	HGNC: 6984	AceView: ME2	Ensembl:ENSG00000082212	euGenes: HUgn4200
ECgene: ME2	Kegg: 4200	H-InvDB: ME2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ME2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ME2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ME2 gene:
Search GeneIP for patents involving ME2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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malic enzyme 2, NAD(+)-dependent, mitochondrial

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malic enzyme 2, NAD(+)-dependent, mitochondrial

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