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Aliases for ME2 Gene

Aliases for ME2 Gene

  • Malic Enzyme 2, NAD(+)-Dependent, Mitochondrial 2 3
  • NAD-ME 3 4
  • ODS1 3 6
  • NAD-Dependent Malic Enzyme, Mitochondrial 3
  • Pyruvic-Malic Carboxylase 3
  • Malate Dehydrogenase 3
  • Malic Enzyme 2 4
  • EC 1.1.1.38 4
  • EC 1.1.1 63

External Ids for ME2 Gene

Previous GeneCards Identifiers for ME2 Gene

  • GC18P048588
  • GC18P048341
  • GC18P046657
  • GC18P046659
  • GC18P048405
  • GC18P045260

Summaries for ME2 Gene

Entrez Gene Summary for ME2 Gene

  • This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for ME2 Gene

ME2 (Malic Enzyme 2, NAD(+)-Dependent, Mitochondrial) is a Protein Coding gene. Diseases associated with ME2 include epilepsy, idiopathic generalized and opioid dependence. Among its related pathways are Glucose / Energy Metabolism and Carbon metabolism. GO annotations related to this gene include electron carrier activity. An important paralog of this gene is ME1.

Gene Wiki entry for ME2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ME2 Gene

Genomics for ME2 Gene

Regulatory Elements for ME2 Gene

Genomic Location for ME2 Gene

Start:
50,879,049 bp from pter
End:
50,954,257 bp from pter
Size:
75,209 bases
Orientation:
Plus strand

Genomic View for ME2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ME2 Gene

Proteins for ME2 Gene

  • Protein details for ME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23368-MAOM_HUMAN
    Recommended name:
    NAD-dependent malic enzyme, mitochondrial
    Protein Accession:
    P23368
    Secondary Accessions:
    • B2R8J2
    • Q9BWL6
    • Q9BYG1
    • Q9H4B2

    Protein attributes for ME2 Gene

    Size:
    584 amino acids
    Molecular mass:
    65444 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal cations. Prefers magnesium or manganese.;
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • This isoenzyme can also use NADP(+) but is more effective with NAD(+)

    Three dimensional structures from OCA and Proteopedia for ME2 Gene

    Alternative splice isoforms for ME2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ME2 Gene

Proteomics data for ME2 Gene at MOPED

Post-translational modifications for ME2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ME2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ME2 Gene

Protein Domains for ME2 Gene

Suggested Antigen Peptide Sequences for ME2 Gene

Graphical View of Domain Structure for InterPro Entry

P23368

UniProtKB/Swiss-Prot:

MAOM_HUMAN :
  • P23368
Family:
  • Belongs to the malic enzymes family.
genes like me logo Genes that share domains with ME2: view

No data available for Gene Families for ME2 Gene

Function for ME2 Gene

Molecular function for ME2 Gene

GENATLAS Biochemistry: malic enzyme 2,mitochondrial
UniProtKB/Swiss-Prot CatalyticActivity: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH
UniProtKB/Swiss-Prot CatalyticActivity: Oxaloacetate = pyruvate + CO(2)
UniProtKB/Swiss-Prot EnzymeRegulation: Subject to allosteric activation by fumarate

Enzyme Numbers (IUBMB) for ME2 Gene

Gene Ontology (GO) - Molecular Function for ME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004470 malic enzyme activity IMP 23334421
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA --
GO:0008948 oxaloacetate decarboxylase activity IEA --
GO:0009055 electron carrier activity TAS 1993674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ME2: view

Phenotypes for ME2 Gene

genes like me logo Genes that share phenotypes with ME2: view

miRNA for ME2 Gene

miRTarBase miRNAs that target ME2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ME2 Gene

Localization for ME2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ME2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ME2 Gene COMPARTMENTS Subcellular localization image for ME2 gene
Compartment Confidence
mitochondrion 5
chloroplast 2
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ME2: view

Pathways for ME2 Gene

genes like me logo Genes that share pathways with ME2: view

Pathways by source for ME2 Gene

1 Cell Signaling Technology pathway for ME2 Gene
2 KEGG pathways for ME2 Gene

Gene Ontology (GO) - Biological Process for ME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006108 malate metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
GO:1902031 regulation of NADP metabolic process IMP 23334421
genes like me logo Genes that share ontologies with ME2: view

Compounds for ME2 Gene

(10) HMDB Compounds for ME2 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
L-Malic acid
  • (-)-(S)-Malate
97-67-6
Magnesium
  • Magnesium
7439-95-4
Malic acid
  • 2-Hydroxybutanedioic acid
6915-15-7
Manganese
  • manganese
7439-96-5

(6) Drugbank Compounds for ME2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Ketomalonic Acid
target
Fumarate
110-17-8 target
Malate Ion
target
NADH
  • beta-DPNH
606-68-8 target
Nicotinamide-Adenine-Dinucleotide
53-84-9 target

(8) Novoseek inferred chemical compound relationships for ME2 Gene

Compound -log(P) Hits PubMed IDs
fumarate 76 4
malate 74.9 6
oxaloacetate 61.2 1
pyruvate 56.9 3
atp 36.1 5
genes like me logo Genes that share compounds with ME2: view

Transcripts for ME2 Gene

Unigene Clusters for ME2 Gene

Malic enzyme 2, NAD(+)-dependent, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ME2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: -
SP2: - - -
SP3:
SP4: -

Relevant External Links for ME2 Gene

GeneLoc Exon Structure for
ME2
ECgene alternative splicing isoforms for
ME2

Expression for ME2 Gene

mRNA expression in normal human tissues for ME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ME2 Gene

SOURCE GeneReport for Unigene cluster for ME2 Gene Hs.233119

genes like me logo Genes that share expressions with ME2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ME2 Gene

Orthologs for ME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ME2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ME2 35
  • 99.54 (n)
  • 99.66 (a)
ME2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ME2 35
  • 90.24 (n)
  • 91.95 (a)
ME2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ME2 35
  • 90.64 (n)
  • 91.61 (a)
ME2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Me2 35
  • 85.22 (n)
  • 89.04 (a)
Me2 16
Me2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ME2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Me2 35
  • 85.27 (n)
  • 88.7 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia me2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia me2 35
  • 71.27 (n)
  • 78.41 (a)
zebrafish
(Danio rerio)
Actinopterygii me2 35
  • 66.21 (n)
  • 75.52 (a)
me2 36
  • 75 (a)
OneToMany
me2 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7848 36
  • 32 (a)
ManyToMany
Men 36
  • 37 (a)
ManyToMany
Men-b 36
  • 48 (a)
ManyToMany
Menl-1 37
  • 45 (a)
Men 37
  • 51 (a)
Mdh 37
  • 54 (a)
Menl-2 37
  • 42 (a)
CG7848 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea men-1 36
  • 46 (a)
OneToMany
Y48B6A.12 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAE1 36
  • 30 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3190 35
thale cress
(Arabidopsis thaliana)
eudicotyledons NADP-ME3 35
  • 56.55 (n)
  • 52.48 (a)
rice
(Oryza sativa)
Liliopsida Os01g0723400 35
  • 55.78 (n)
  • 50.37 (a)
Species with no ortholog for ME2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ME2 Gene

ENSEMBL:
Gene Tree for ME2 (if available)
TreeFam:
Gene Tree for ME2 (if available)

Paralogs for ME2 Gene

Paralogs for ME2 Gene

Pseudogenes.org Pseudogenes for ME2 Gene

genes like me logo Genes that share paralogs with ME2: view

Variants for ME2 Gene

Sequence variations from dbSNP and Humsavar for ME2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs12277 -- 50,947,383(+) CTACA(A/G)TCAGA utr-variant-3-prime
rs582571 -- 50,919,249(-) TGACA(A/T)AATGA intron-variant
rs582604 -- 50,933,765(+) CCCGG(C/G)TAATA intron-variant
rs583574 -- 50,907,213(-) agccc(C/T)attcc intron-variant
rs584333 -- 50,918,898(-) GAATA(C/T)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ME2 Gene

Variant ID Type Subtype PubMed ID
nsv9630 CNV Loss 18304495
nsv527714 CNV Gain 19592680

Relevant External Links for ME2 Gene

HapMap Linkage Disequilibrium report
ME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ME2 Gene

Disorders for ME2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ME2 Gene including...

Search for ME2 Gene in MalaCards »

(2) OMIM Diseases for ME2 Gene (154270)

(2) University of Copenhagen DISEASES for ME2 Gene

(3) Novoseek inferred disease relationships for ME2 Gene

Disease -log(P) Hits PubMed IDs
epilepsy, idiopathic generalized 73.1 2
epilepsy generalized 69.5 2
tumors 0 1

Relevant External Links for ME2

Genetic Association Database (GAD)
ME2
Human Genome Epidemiology (HuGE) Navigator
ME2
genes like me logo Genes that share disorders with ME2: view

No data available for UniProtKB/Swiss-Prot for ME2 Gene

Publications for ME2 Gene

  1. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. (PMID: 11401430) Yanaihara N. … Yokota J. (Genomics 2001) 3 4 23
  2. Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. (PMID: 16190936) Lenzen K.P. … Sander T. (Epilepsia 2005) 3 23 48
  3. Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli. (PMID: 1993674) Loeber G. … Dworkin M.B. (J. Biol. Chem. 1991) 2 3 4
  4. Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases. (PMID: 10467136) Xu Y. … Tong L. (Structure 1999) 3 4
  5. Structure of a closed form of human malic enzyme and implications for catalytic mechanism. (PMID: 10700286) Yang Z. … Tong L. (Nat. Struct. Biol. 2000) 3 4

Products for ME2 Gene

Sources for ME2 Gene

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