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Aliases for ME1 Gene

Aliases for ME1 Gene

  • Malic Enzyme 1 2 3 4
  • Malic Enzyme 1, NADP(+)-Dependent, Cytosolic 2 3 5
  • Malate Dehydrogenase (Oxaloacetate-Decarboxylating) (NADP(+)) 2 3
  • EC 4 63
  • NADP-ME 3 4
  • NADP-Dependent Malic Enzyme 2
  • Malic Enzyme, Cytoplasmic 3
  • Pyruvic-Malic Carboxylase 3
  • Malic Enzyme 1, Soluble 3
  • Malate Dehydrogenase 3
  • EC 1.1.1 63
  • MES 3

External Ids for ME1 Gene

Previous GeneCards Identifiers for ME1 Gene

  • GC06M083867
  • GC06M083916
  • GC06M083977
  • GC06M083920
  • GC06M081148

Summaries for ME1 Gene

Entrez Gene Summary for ME1 Gene

  • This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

GeneCards Summary for ME1 Gene

ME1 (Malic Enzyme 1) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Carbon metabolism. GO annotations related to this gene include electron carrier activity and NAD binding. An important paralog of this gene is ME2.

Gene Wiki entry for ME1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ME1 Gene

Genomics for ME1 Gene

Regulatory Elements for ME1 Gene

Enhancers for ME1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ME1 on UCSC Golden Path with GeneCards custom track

Promoters for ME1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ME1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ME1 Gene

83,210,389 bp from pter
83,431,741 bp from pter
221,353 bases
Minus strand

Genomic View for ME1 Gene

Genes around ME1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ME1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ME1 Gene

Proteins for ME1 Gene

  • Protein details for ME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADP-dependent malic enzyme
    Protein Accession:
    Secondary Accessions:
    • B4DZ70
    • Q16797
    • Q16855
    • Q53F72
    • Q5VWA2
    • Q9BWX8
    • Q9H1W3
    • Q9UIY4

    Protein attributes for ME1 Gene

    572 amino acids
    Molecular mass:
    64150 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ME1 Gene

    Alternative splice isoforms for ME1 Gene


neXtProt entry for ME1 Gene

Proteomics data for ME1 Gene at MOPED

Post-translational modifications for ME1 Gene

  • Ubiquitination at Lys 26 and Lys 60
  • Modification sites at PhosphoSitePlus

Other Protein References for ME1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ME1

Domains & Families for ME1 Gene

Protein Domains for ME1 Gene

Suggested Antigen Peptide Sequences for ME1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the malic enzymes family.
  • Belongs to the malic enzymes family.
genes like me logo Genes that share domains with ME1: view

No data available for Gene Families for ME1 Gene

Function for ME1 Gene

Molecular function for ME1 Gene

GENATLAS Biochemistry:
malic enzyme 1,soluble
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
Oxaloacetate = pyruvate + CO(2).

Enzyme Numbers (IUBMB) for ME1 Gene

Gene Ontology (GO) - Molecular Function for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA --
GO:0005515 protein binding IEA --
GO:0008948 oxaloacetate decarboxylase activity IEA --
GO:0043531 ADP binding TAS 7622060
GO:0050661 NADP binding TAS 7622060
genes like me logo Genes that share ontologies with ME1: view
genes like me logo Genes that share phenotypes with ME1: view

Animal Model Products

miRNA for ME1 Gene

miRTarBase miRNAs that target ME1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ME1 Gene

Localization for ME1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ME1 Gene


Subcellular locations from

Jensen Localization Image for ME1 Gene COMPARTMENTS Subcellular localization image for ME1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
chloroplast 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ME1 Gene

Pathways & Interactions for ME1 Gene

genes like me logo Genes that share pathways with ME1: view

Gene Ontology (GO) - Biological Process for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006108 malate metabolic process IEA,IDA 7622060
GO:0009743 response to carbohydrate TAS 8187880
GO:0044281 small molecule metabolic process TAS --
GO:0051262 protein tetramerization IEA --
GO:1902031 regulation of NADP metabolic process IMP 23334421
genes like me logo Genes that share ontologies with ME1: view

No data available for SIGNOR curated interactions for ME1 Gene

Drugs & Compounds for ME1 Gene

(9) Drugs for ME1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
NADH Nutra Target 0
malic acid Pharma Agonist, Activator 0
Manganese Pharma 32

(8) Additional Compounds for ME1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
L-Malic acid
  • (-)-(S)-Malate
  • (-)-(S)-Malic acid
  • (-)-Hydroxysuccinate
  • (-)-Hydroxysuccinic acid
  • (-)-L-Malic acid
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
genes like me logo Genes that share compounds with ME1: view

Transcripts for ME1 Gene

mRNA/cDNA for ME1 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(236) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ME1 Gene

Malic enzyme 1, NADP(+)-dependent, cytosolic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ME1 Gene

No ASD Table

Relevant External Links for ME1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ME1 Gene

mRNA expression in normal human tissues for ME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ME1 Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for ME1 Gene

This gene is overexpressed in Retina (15.6), Brain (6.4), and Nasopharynx (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ME1 Gene

SOURCE GeneReport for Unigene cluster for ME1 Gene Hs.21160

mRNA Expression by UniProt/SwissProt for ME1 Gene

Tissue specificity: Expressed in all tissues tested including liver, placenta and white adipose tissue.
genes like me logo Genes that share expression patterns with ME1: view

Protein tissue co-expression partners for ME1 Gene

Primer Products

Orthologs for ME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ME1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ME1 35
  • 91.33 (n)
  • 91.94 (a)
ME1 36
  • 83 (a)
(Canis familiaris)
Mammalia ME1 35
  • 92.31 (n)
  • 93.41 (a)
ME1 36
  • 91 (a)
(Mus musculus)
Mammalia Me1 35
  • 86.54 (n)
  • 90.03 (a)
Me1 16
Me1 36
  • 90 (a)
(Pan troglodytes)
Mammalia ME1 35
  • 99.77 (n)
  • 99.65 (a)
ME1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Me1 35
  • 86.42 (n)
  • 90.38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
-- 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia ME1 36
  • 82 (a)
(Gallus gallus)
Aves ME1 35
  • 76.88 (n)
  • 77.84 (a)
ME1 36
  • 67 (a)
(Anolis carolinensis)
Reptilia ME1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia me1 35
  • 74.24 (n)
  • 77.64 (a)
Str.5724 35
(Danio rerio)
Actinopterygii me1 36
  • 68 (a)
ME1 (2 of 2) 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7848 37
  • 36 (a)
Mdh 37
  • 56 (a)
Men 37
  • 58 (a)
Menl-1 37
  • 47 (a)
Menl-2 37
  • 45 (a)
Men 35
  • 56.77 (n)
  • 59.04 (a)
CG7848 36
  • 31 (a)
Men 36
  • 42 (a)
Men-b 36
  • 50 (a)
Menl-1 36
  • 41 (a)
Menl-2 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000184 35
  • 56.35 (n)
  • 61.17 (a)
(Caenorhabditis elegans)
Secernentea Y48B6A.12 37
  • 52 (a)
men-1 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAE1 36
  • 32 (a)
MAE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NADP-ME4 35
  • 57.24 (n)
  • 52.06 (a)
(Oryza sativa)
Liliopsida Os.421 35
Os05g0186300 35
  • 54 (n)
  • 53.18 (a)
(Triticum aestivum)
Liliopsida Ta.7720 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03651 35
  • 50.19 (n)
  • 44.02 (a)
Species with no ortholog for ME1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ME1 Gene

Gene Tree for ME1 (if available)
Gene Tree for ME1 (if available)

Paralogs for ME1 Gene

Paralogs for ME1 Gene

genes like me logo Genes that share paralogs with ME1: view

Variants for ME1 Gene

Sequence variations from dbSNP and Humsavar for ME1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1012741 -- 83,229,727(+) ACCCC(A/G)GGCAA intron-variant
rs1013317 -- 83,269,892(-) TTAAT(A/G)AAGAC intron-variant
rs1013318 -- 83,269,728(-) GTCTC(C/T)GAGGA intron-variant
rs1016242 -- 83,245,852(-) AAAAA(A/T)TTAGA intron-variant
rs1044946 -- 83,223,841(-) TCCTA(C/T)GTGTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ME1 Gene

Variant ID Type Subtype PubMed ID
esv1303011 CNV Deletion 17803354
esv2732363 CNV Deletion 23290073
esv1011019 CNV Insertion 20482838
esv2660285 CNV Deletion 23128226
esv2732364 CNV Deletion 23290073
nsv823766 CNV Gain 20364138

Variation tolerance for ME1 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ME1 Gene

Disorders for ME1 Gene

Relevant External Links for ME1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ME1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ME1 Gene

Publications for ME1 Gene

  1. Characterization of cytosolic malic enzyme in human tumor cells. (PMID: 8187880) Loeber G. … Ahorn H. (FEBS Lett. 1994) 2 3 4 67
  2. A new locus for autosomal dominant dilated cardiomyopathy identified on chromosome 6q12-q16. (PMID: 11085912) Sylvius N. … Komajda M. (Am. J. Hum. Genet. 2001) 3 23
  3. Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. (PMID: 7622060) Gonzalez-Manchon C. … Parrilla R. (Gene 1995) 3 23
  4. Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma. (PMID: 25753478) Wen D. … Wu W. (Tumour Biol. 2015) 3
  5. Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer. (PMID: 26173780) Chakrabarti G. (Radiat Oncol 2015) 3

Products for ME1 Gene

Sources for ME1 Gene