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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ME1 Gene

protein-coding   GIFtS: 63
GCID: GC06M083920

malic enzyme 1, NADP(+)-dependent, cytosolic
 Explore 11 diseases affiliated with
ME1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ME1    

Aliases
for ME1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Malic Enzyme 1, NADP(+)-Dependent, Cytosolic1 2     Malic Enzyme 1, Soluble2
NADP-ME2 3     Malic Enzyme, Cytoplasmic2
EC 1.1.1.403 8     NADP-Dependent Malic Enzyme2
HUMNDME2     Pyruvic-Malic Carboxylase2
MES2     Malic Enzyme 13
Malate Dehydrogenase2     EC 1.1.18

External Ids:    HGNC: 69831   Entrez Gene: 41992   Ensembl: ENSG000000658337   OMIM: 1542505   UniProtKB: P481633   

Export aliases for ME1 gene to outside databases

Previous GC identifers: GC06M083867 GC06M083916 GC06M083977 GC06M081148


Summaries
for ME1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ME1:
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of
this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The
regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid
hormones or by higher proportions of carbohydrates in the diet. (provided by RefSeq, Jul 2008)

Gene Wiki entry for ME1


Genomic Views
for ME1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ME1 gene promoter:
         COUP-TF1   p53   HNF-4alpha2   CUTL1   HNF-4alpha1   C/EBPalpha   FOXL1   AREB6   RORalpha1   S8   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ME1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ME1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ME1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q12

ME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ME1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M083920:  view genomic region     (about GC identifiers)

Start:
 83,920,108 bp from pter      End:
 84,140,938 bp from pter
Size:
 220,831 bases      Orientation:
 minus strand

Proteins
for ME1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAOX_HUMAN, P48163 (See protein sequence)
Recommended Name: NADP-dependent malic enzyme  
Size: 572 amino acids; 64150 Da
Cofactor: Divalent metal cations. Prefers magnesium or manganese (By similarity)
Subunit: Homotetramer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for ME1:
2AW5 (3D)    
Secondary accessions: Q16797 Q16855 Q53F72 Q5VWA2 Q9BWX8 Q9H1W3 Q9UIY4

Explore the universe of human proteins at neXtProt for ME1: NX_P48163

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48163

    • 4/24 DME Specific Peptides for ME1 (P48163) (see all 24)
     VYTPTVG  GSPFDPV  FASGSPF  GRLYPPL 

    ME1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002386.1  
    ENSEMBL proteins: 
     ENSP00000358719   ENSP00000446114   ENSP00000439912  
    Reactome Protein details: P48163
    Human Recombinant Protein Products: 
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    Novus Biologicals ME1 Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--


    ME1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ME1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ME1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR012301 Malic_N
     IPR012302 Malic_NAD-bd
     IPR015884 Malic_enzyme_CS
     IPR001891 Malic_OxRdtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P48163

    ProtoNet protein and cluster: P48163

    1 Blocks protein family: IPB001891 Malic oxidoreductase

    UniProtKB/Swiss-Prot: MAOX_HUMAN, P48163
    Similarity: Belongs to the malic enzymes family


    Function
    for ME1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAOX_HUMAN, P48163
    Catalytic activity: (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH
    Catalytic activity: Oxaloacetate = pyruvate + CO(2)

         Genatlas biochemistry entry for ME1:
    malic enzyme 1,soluble

    Enzyme Numbers (IUBMB): EC 1.1.1.401 2 EC 1.1.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ME1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ME1 (see all 25):
    hsa-miR-30c hsa-miR-548j hsa-miR-448 hsa-miR-548i hsa-miR-30d hsa-miR-507 hsa-miR-30a hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmid: ME1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ME1 (see all 4)
    OriGene shRNA RFP: ME1
    OriGene siRNA: ME1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ME1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ME1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ME1 

    Cell Line
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    Search LifeMap BioReagents cell lines for ME1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ME1

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004470malic enzyme activity IDA8187880
    GO:0004473malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity ISS--
    GO:0009055electron carrier activity TAS7622060
    GO:0016619malate dehydrogenase (oxaloacetate-decarboxylating) activity IEA--
    GO:0030145manganese ion binding IDA7622060


    ME1 for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Me1):
     behavior/neurological  growth/size  homeostasis/metabolism  mortality/aging 

    ME1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ME1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    3Expression of ME1
    		Expression of ME11.00
    4PPAR signaling pathway
    		PPAR signaling pathway1.00
    5Pyruvate metabolism
    		Pyruvate metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for ME1 (see all 6)
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    PPARA Activates Gene Expression
    Expression of ME1
    Fatty acid, triacylglycerol, and ketone body metabolism


    3         Kegg Pathways  (Kegg details for ME1):
        Pyruvate metabolism
    Metabolic pathways
    PPAR signaling pathway


    ME1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ME1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/128 Interacting proteins for ME1 (P481633 ENSP000003587194) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS8187880
    GO:0006108malate metabolic process IDA8187880
    GO:0006741NADP biosynthetic process TAS8187880
    GO:0009725response to hormone stimulus ISS--
    GO:0009743response to carbohydrate stimulus TAS8187880


    ME1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ME1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ME1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ME1

    10 HMDB Compounds for ME1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    L-Malic acid(-)-(S)-Malate (see all 27)97-67-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Malic acid2-Hydroxybutanedioic acid (see all 24)6915-15-7--
    Manganesemanganese 7439-96-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    2 DrugBank Compounds for ME1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423 10592235
    NADHbeta-DPNH (see all 18)606-68-8target--17197218

    4 Novoseek chemical compound relationships for ME1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malate 72.4 5 19931439 (1), 1368216 (1), 11172800 (1), 2043615 (1) (see all 5)
    phosphoenolpyruvate 67.2 5 8704306 (1), 15290293 (1), 16464879 (1), 16228537 (1) (see all 5)
    isocitrate 59.3 2 19931439 (1), 11326687 (1)
    pyruvate 45.8 3 12685039 (1), 18445600 (1), 17928289 (1)

    Search CenterWatch for drugs/clinical trials and news about ME1 / MAOX 

    Transcripts
    for ME1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ME1 gene: 
    NM_002395.4  

    Unigene Cluster for ME1:

    Malic enzyme 1, NADP(+)-dependent, cytosolic
    Hs.21160  [show with all ESTs]
    Unigene Representative Sequence: NM_002395
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369705(uc003pjy.3 uc011dzb.2 uc011dzc.2) ENST00000543031
    ENST00000541327

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ME1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ME1 (see all 25):
    hsa-miR-30c hsa-miR-548j hsa-miR-448 hsa-miR-548i hsa-miR-30d hsa-miR-507 hsa-miR-30a hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmid: ME1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ME1 (see all 4)
    OriGene shRNA RFP: ME1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ420574.1 AK223417.1 AK289783.1 AK301875.1 AK302777.1 BC017403.1 BC025246.1 L34035.1 
    U43944.1 X77244.1 

    10 DOTS entries:

    DT.214180  DT.121372107  DT.92449275  DT.100797729  DT.92449265  DT.100797733  DT.100797737  DT.121372126 
    DT.95269623  DT.121372118 

    24/236 AceView cDNA sequences (see all 236):

    BF434425 CB160273 AI337365 BQ631261 AA927767 F02108 BC017403 AW612304 
    AA453431 CB143689 BC025246 CA441611 CB163735 BU616849 CA867156 T16759 
    AA443185 AA948268 BG192549 BG110590 U43944 CD677021 CR601714 BX371460 

    GeneLoc Exon Structure


    Expression
    for ME1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ME1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACAATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ME1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ME1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ME1

    SOURCE GeneReport for Unigene cluster: Hs.21160

    UniProtKB/Swiss-Prot: MAOX_HUMAN, P48163
    Tissue specificity: Expressed in all tissues tested including liver, placenta and white adipose tissue

        SABiosciences Expression via Pathway-Focused PCR Array including ME1: 
              Diabetes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ME1

    Orthologs
    for ME1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ME1 gene from 11/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Me11 , 5 malic enzyme 1, NADP(+)-dependent, cytosolic1, 5 86.54(n)1
    90.03(a)1    		   9 (46.58 cM)5
    174361  NM_008615.21  NP_032641.21 
     865813635 
    chicken
    (Gallus gallus)    		 Aves ME11 malic enzyme 1, NADP(+)-dependent, cytosolic 76.88(n)
    77.84(a)    		   374189  NM_204303.1  NP_989634.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ME16
    		 --
    		 72(a)
    		 1 ↔ 1
    		 1(197593688-197719377)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.57242 Transcribed sequence with moderate similarity to protein more 77.38(n)    BQ525274.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003343831 NADP-dependent malic enzyme-like 68.93(n)
    73.35(a)    		   100334383  XM_002664939.2  XP_002664985.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Men3
    Men-b1    		 malate dehydrogenase (oxaloacetate
    decarboxylating) more3
    Malic enzyme b1    		 58(a)
    (best of 5)3
    55.6(n)1
    56.68(a)1    		   439361  NM_143702.31  NP_651959.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y48B6A.123   -- 52(a)   II(14226477-14233689)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes MAE1(YKL029C)4
    MAE11    		 Mitochondrial malic enzyme, catalyzes the oxidative more4
    Mae1p1    		 48.4(n)1
    40.49(a)1    		   11(384725-382716)4
    8538391, 4  NP_012896.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NADP-ME11 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) 56.87(n)
    52.06(a)    		   816509  NM_127548.3  NP_179580.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.4212 Oryza sativa (japonica cultivar-group) NADP-ME2 mRNA more 73.41(n)    AK065560.1 


    ENSEMBL Gene Tree for ME1 (if available)
    TreeFam Gene Tree for ME1 (if available) 

    Paralogs
    for ME1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ME1 gene
    ME32  ME22  
    18/50 SIMAP similar genes for ME1 using alignment to 4 protein entries:     MAOX_HUMAN (see all proteins) (see all similar genes):
    ME3    PCDHB3    PCDHB6    PCDHB14    PCDHB9    ME4
    PCDHB2    PCDHB8    DKFZp586I1919    PCDHB12    PCDHB7    PCDHB11
    ME2    PCDHA13    PCDHA3    PCDHGA1    ME6    PCDHAC2

    ME1 for paralogs           About GeneDecksing



    Genomic Variants
    for ME1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3425 NCBI SNPs in ME1 are shown (see all 3425)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1826212791,2
    		--83919687(+) CCAGAA/GTATGT 1 -- ds50010--------
    rs2008052761,2
    		--83919698(+) ATTAC-/ATATATA 1 -- ds50010--------
    rs1995587611,2
    		C,--83919708(+) TATAT-/ATTTTT 1 -- ds50010--------
    rs132029231,2
    		C,A,--83919709(+) TATATT/ATTTTT 1 -- ds50016Minor allele frequency- A:0.41NA WA CSA 245
    rs1175669341,2
    		F,--83919735(+) TCTTAC/TTCCAT 1 -- ds50011Minor allele frequency- T:0.06EA 120
    rs1465478981,2
    		--83919748(+) CCCAGA/GCTGGA 1 -- ds50010--------
    rs1416246591,2
    		--83920008(+) TTTTA-/AATG  
                AATGA     		1 -- ds50010--------
    rs1167071931,2
    		--83920089(+) AAGACC/AAAGCA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1869120261,2
    		--83920161(+) CTATGC/TTTTAA 1 -- ut310--------
    rs1924203281,2
    		--83920242(+) CAGACA/CTTCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ME1 (83920108 - 84140938 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ME1
         1 CNV: 81478

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    Disorders / Diseases
    for ME1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ME1 for disorders           About GeneDecksing

    OMIM gene information: 154250    OMIM disorders: --

    11 diseases for ME1:    About MalaCards
    thyroiditis    benign mesothelioma    dilated cardiomyopathy    fascioliasis
    cardiomyopathy    lung cancer    breast cancer    cholesterol
    tuberculosis    mycobacterium tuberculosis    alcoholism

    Genetic Association Database (GAD): ME1
    Human Genome Epidemiology (HuGE) Navigator: ME1 (4 documents)

    Export disorders for ME1 gene to outside databases

    Publications
    for ME1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ME1 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with ME1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cytosolic malic enzyme in human tumor cells. (PubMed id 8187880)1, 2, 3 Loeber G.... Ahorn H. (1994)
    2. Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. (PubMed id 7622060)1, 2, 9 Gonzalez-Manchon C.... Parrilla R. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer. (PubMed id 11352855)1, 4 Zhou W....Christiani D.C. (2001)
    6. Nonidentity of the cDNA sequence of human breast cancer cell malic enzyme to that from the normal human cell. (PubMed id 8804575)1, 2 Chou W.Y.... Chang G.G. (1996)
    7. A new locus for autosomal dominant dilated cardiomyopathy identified on chromosome 6q12-q16. (PubMed id 11085912)1, 9 Sylvius N....Komajda M. (2001)
    8. Reciprocal regulation of p53 and malic enzymes modulat es metabolism and senescence. (PubMed id 23334421)1 Jiang P....Yang X. (2013)
    9. Malic enzyme gene polymorphism is associated with resp onsiveness in circulating parathyroid hormone after long-term calcium supplement ation. (PubMed id 22456781)1 Chailurkit L....Ongphiphadhanakul B. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for ME1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ME1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4199 HGNC: 6983 AceView: ME1 Ensembl:ENSG00000065833 euGenes: HUgn4199
    ECgene: ME1 Kegg: 4199 H-InvDB: ME1

    Other Databases showing ME1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ME1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ME1 Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ME1

    Intellectual Property
    for ME1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ME1 gene:
    Search GeneIP for patents involving ME1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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