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Aliases for ME1 Gene

Aliases for ME1 Gene

  • Malic Enzyme 1 2 3 4 5
  • Malate Dehydrogenase (Oxaloacetate-Decarboxylating) (NADP(+)) 2 3
  • Malic Enzyme 1, NADP(+)-Dependent, Cytosolic 2 3
  • NADP-Dependent Malic Enzyme 2 3
  • EC 1.1.1.40 4 61
  • NADP-ME 3 4
  • Malic Enzyme, Cytoplasmic 3
  • Pyruvic-Malic Carboxylase 3
  • Malic Enzyme 1, Soluble 3
  • Malate Dehydrogenase 3
  • EC 1.1.1 61
  • HUMNDME 3
  • MES 3

External Ids for ME1 Gene

Previous GeneCards Identifiers for ME1 Gene

  • GC06M083867
  • GC06M083916
  • GC06M083977
  • GC06M083920
  • GC06M081148

Summaries for ME1 Gene

Entrez Gene Summary for ME1 Gene

  • This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

GeneCards Summary for ME1 Gene

ME1 (Malic Enzyme 1) is a Protein Coding gene. Among its related pathways are PPAR signaling pathway and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include electron carrier activity and NAD binding. An important paralog of this gene is ME3.

Gene Wiki entry for ME1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ME1 Gene

Genomics for ME1 Gene

Regulatory Elements for ME1 Gene

Enhancers for ME1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ME1 on UCSC Golden Path with GeneCards custom track

Promoters for ME1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ME1 Gene

Chromosome:
6
Start:
83,210,389 bp from pter
End:
83,431,741 bp from pter
Size:
221,353 bases
Orientation:
Minus strand

Genomic View for ME1 Gene

Genes around ME1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ME1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ME1 Gene

Proteins for ME1 Gene

  • Protein details for ME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48163-MAOX_HUMAN
    Recommended name:
    NADP-dependent malic enzyme
    Protein Accession:
    P48163
    Secondary Accessions:
    • B4DZ70
    • Q16797
    • Q16855
    • Q53F72
    • Q5VWA2
    • Q9BWX8
    • Q9H1W3
    • Q9UIY4

    Protein attributes for ME1 Gene

    Size:
    572 amino acids
    Molecular mass:
    64150 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ME1 Gene

    Alternative splice isoforms for ME1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ME1 Gene

Post-translational modifications for ME1 Gene

  • Ubiquitination at Lys 26 and Lys 60
  • Modification sites at PhosphoSitePlus

Other Protein References for ME1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ME1 Gene

Protein Domains for ME1 Gene

Suggested Antigen Peptide Sequences for ME1 Gene

Graphical View of Domain Structure for InterPro Entry

P48163

UniProtKB/Swiss-Prot:

MAOX_HUMAN :
  • Belongs to the malic enzymes family.
Family:
  • Belongs to the malic enzymes family.
genes like me logo Genes that share domains with ME1: view

No data available for Gene Families for ME1 Gene

Function for ME1 Gene

Molecular function for ME1 Gene

GENATLAS Biochemistry:
malic enzyme 1,soluble
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
Oxaloacetate = pyruvate + CO(2).

Enzyme Numbers (IUBMB) for ME1 Gene

Gene Ontology (GO) - Molecular Function for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004470 malic enzyme activity IMP 23334421
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA --
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity IEA,ISS --
GO:0005515 protein binding IEA --
GO:0008948 oxaloacetate decarboxylase activity IEA --
genes like me logo Genes that share ontologies with ME1: view
genes like me logo Genes that share phenotypes with ME1: view

Animal Model Products

CRISPR Products

miRNA for ME1 Gene

miRTarBase miRNAs that target ME1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ME1
  • Addgene plasmids for ME1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ME1 Gene

Localization for ME1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ME1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ME1 Gene COMPARTMENTS Subcellular localization image for ME1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
chloroplast 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ME1: view

Pathways & Interactions for ME1 Gene

genes like me logo Genes that share pathways with ME1: view

Gene Ontology (GO) - Biological Process for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 8187880
GO:0006108 malate metabolic process IDA 7622060
GO:0006741 NADP biosynthetic process TAS 8187880
GO:0009725 response to hormone ISS --
GO:0009743 response to carbohydrate TAS 8187880
genes like me logo Genes that share ontologies with ME1: view

No data available for SIGNOR curated interactions for ME1 Gene

Drugs & Compounds for ME1 Gene

(10) Drugs for ME1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Vet_approved Pharma 0
Manganese Approved Nutra 33
Pyruvic acid Approved Nutra 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
NADH Nutra Target 0

(7) Additional Compounds for ME1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
L-Malic acid
  • (-)-(S)-Malate
  • (-)-(S)-Malic acid
  • (-)-Hydroxysuccinate
  • (-)-Hydroxysuccinic acid
  • (-)-L-Malic acid
97-67-6
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Oxalacetic acid
  • 2-Ketosuccinate
  • 2-Ketosuccinic acid
  • 2-Oxobutanedioate
  • 2-Oxobutanedioic acid
  • 2-Oxosuccinate
328-42-7
genes like me logo Genes that share compounds with ME1: view

Transcripts for ME1 Gene

mRNA/cDNA for ME1 Gene

Unigene Clusters for ME1 Gene

Malic enzyme 1, NADP(+)-dependent, cytosolic:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ME1
  • Addgene plasmids for ME1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ME1 Gene

No ASD Table

Relevant External Links for ME1 Gene

GeneLoc Exon Structure for
ME1
ECgene alternative splicing isoforms for
ME1

Expression for ME1 Gene

mRNA expression in normal human tissues for ME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ME1 Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for ME1 Gene

This gene is overexpressed in Retina (15.6), Brain (6.4), and Nasopharynx (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ME1 Gene



Protein tissue co-expression partners for ME1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ME1 Gene:

ME1

SOURCE GeneReport for Unigene cluster for ME1 Gene:

Hs.21160

mRNA Expression by UniProt/SwissProt for ME1 Gene:

P48163-MAOX_HUMAN
Tissue specificity: Expressed in all tissues tested including liver, placenta and white adipose tissue.
genes like me logo Genes that share expression patterns with ME1: view

Primer Products

Orthologs for ME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ME1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ME1 34
  • 91.33 (n)
  • 91.94 (a)
ME1 35
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ME1 34
  • 92.31 (n)
  • 93.41 (a)
ME1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Me1 34
  • 86.54 (n)
  • 90.03 (a)
Me1 16
Me1 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ME1 34
  • 99.77 (n)
  • 99.65 (a)
ME1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Me1 34
  • 86.42 (n)
  • 90.38 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ME1 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ME1 34
  • 76.88 (n)
  • 77.84 (a)
ME1 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ME1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia me1 34
  • 74.24 (n)
  • 77.64 (a)
Str.5724 34
zebrafish
(Danio rerio)
Actinopterygii me1 35
  • 68 (a)
OneToMany
ME1 (2 of 2) 35
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7848 36
  • 36 (a)
Mdh 36
  • 56 (a)
Men 36
  • 58 (a)
Menl-1 36
  • 47 (a)
Menl-2 36
  • 45 (a)
Men 34
  • 56.77 (n)
  • 59.04 (a)
CG7848 35
  • 31 (a)
ManyToMany
Men 35
  • 42 (a)
ManyToMany
Men-b 35
  • 50 (a)
ManyToMany
Menl-1 35
  • 41 (a)
ManyToMany
Menl-2 35
  • 39 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000184 34
  • 56.35 (n)
  • 61.17 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48B6A.12 36
  • 52 (a)
men-1 35
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAE1 35
  • 32 (a)
OneToMany
MAE1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons NADP-ME4 34
  • 57.24 (n)
  • 52.06 (a)
rice
(Oryza sativa)
Liliopsida Os.421 34
Os05g0186300 34
  • 54 (n)
  • 53.18 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7720 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03651 34
  • 50.19 (n)
  • 44.02 (a)
Species where no ortholog for ME1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ME1 Gene

ENSEMBL:
Gene Tree for ME1 (if available)
TreeFam:
Gene Tree for ME1 (if available)

Paralogs for ME1 Gene

Paralogs for ME1 Gene

genes like me logo Genes that share paralogs with ME1: view

Variants for ME1 Gene

Sequence variations from dbSNP and Humsavar for ME1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs767144 -- 83,267,083(-) AATTA(A/C)CCTTC intron-variant
rs976065 -- 83,382,795(+) GAAGA(C/T)TCAAG intron-variant
rs983087 -- 83,244,545(-) CCACC(A/G)CTATT intron-variant
rs983140 -- 83,394,177(-) ACTAA(A/T)TTTTT intron-variant
rs1012741 -- 83,229,727(+) ACCCC(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ME1 Gene

Variant ID Type Subtype PubMed ID
esv1011019 CNV insertion 20482838
esv1303011 CNV deletion 17803354
esv2660285 CNV deletion 23128226
esv2732363 CNV deletion 23290073
esv2732364 CNV deletion 23290073
esv3571274 CNV loss 25503493
esv3571275 CNV loss 25503493
esv3609774 CNV gain 21293372
esv3609775 CNV loss 21293372
esv3609776 CNV loss 21293372
nsv1129432 OTHER inversion 24896259
nsv1131995 CNV deletion 24896259
nsv1141517 CNV duplication 24896259
nsv823766 CNV gain 20364138
nsv970146 CNV duplication 23825009

Variation tolerance for ME1 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ME1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ME1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ME1 Gene

Disorders for ME1 Gene

Relevant External Links for ME1

Genetic Association Database (GAD)
ME1
Human Genome Epidemiology (HuGE) Navigator
ME1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ME1

No disorders were found for ME1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ME1 Gene

Publications for ME1 Gene

  1. Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. (PMID: 7622060) Gonzalez-Manchon C. … Parrilla R. (Gene 1995) 3 4 22 65
  2. Characterization of cytosolic malic enzyme in human tumor cells. (PMID: 8187880) Loeber G. … Ahorn H. (FEBS Lett. 1994) 2 3 4 65
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 46 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ME1 Gene

Sources for ME1 Gene

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