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Aliases for ME1 Gene

Aliases for ME1 Gene

  • Malic Enzyme 1, NADP(+)-Dependent, Cytosolic 2 3
  • EC 1.1.1.40 4 63
  • NADP-ME 3 4
  • Pyruvic-Malic Carboxylase 3
  • Malic Enzyme, Cytoplasmic 3
  • Malic Enzyme 1, Soluble 3
  • Malate Dehydrogenase 3
  • Malic Enzyme 1 4
  • EC 1.1.1 63
  • HUMNDME 3
  • MES 3

External Ids for ME1 Gene

Previous GeneCards Identifiers for ME1 Gene

  • GC06M083867
  • GC06M083916
  • GC06M083977
  • GC06M083920
  • GC06M081148

Summaries for ME1 Gene

Entrez Gene Summary for ME1 Gene

  • This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

GeneCards Summary for ME1 Gene

ME1 (Malic Enzyme 1, NADP(+)-Dependent, Cytosolic) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include electron carrier activity and NAD binding. An important paralog of this gene is ME2.

Gene Wiki entry for ME1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ME1 Gene

Genomics for ME1 Gene

Regulatory Elements for ME1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ME1 Gene

Chromosome:
6
Start:
83,210,389 bp from pter
End:
83,431,741 bp from pter
Size:
221,353 bases
Orientation:
Minus strand

Genomic View for ME1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ME1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ME1 Gene

Proteins for ME1 Gene

  • Protein details for ME1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48163-MAOX_HUMAN
    Recommended name:
    NADP-dependent malic enzyme
    Protein Accession:
    P48163
    Secondary Accessions:
    • B4DZ70
    • Q16797
    • Q16855
    • Q53F72
    • Q5VWA2
    • Q9BWX8
    • Q9H1W3
    • Q9UIY4

    Protein attributes for ME1 Gene

    Size:
    572 amino acids
    Molecular mass:
    64150 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal cations. Prefers magnesium or manganese.;
    Quaternary structure:
    • Homotetramer

    Three dimensional structures from OCA and Proteopedia for ME1 Gene

    Alternative splice isoforms for ME1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ME1 Gene

Proteomics data for ME1 Gene at MOPED

Post-translational modifications for ME1 Gene

  • Ubiquitination at Lys 26 and Lys 60
  • Modification sites at PhosphoSitePlus

Other Protein References for ME1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ME1 Gene

Protein Domains for ME1 Gene

Suggested Antigen Peptide Sequences for ME1 Gene

Graphical View of Domain Structure for InterPro Entry

P48163

UniProtKB/Swiss-Prot:

MAOX_HUMAN :
  • Belongs to the malic enzymes family.
Family:
  • Belongs to the malic enzymes family.
genes like me logo Genes that share domains with ME1: view

No data available for Gene Families for ME1 Gene

Function for ME1 Gene

Molecular function for ME1 Gene

GENATLAS Biochemistry:
malic enzyme 1,soluble
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH
UniProtKB/Swiss-Prot CatalyticActivity:
Oxaloacetate = pyruvate + CO(2)

Enzyme Numbers (IUBMB) for ME1 Gene

Gene Ontology (GO) - Molecular Function for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004470 malic enzyme activity IMP 23334421
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA --
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity ISS --
GO:0005515 protein binding --
GO:0008948 oxaloacetate decarboxylase activity IEA --
genes like me logo Genes that share ontologies with ME1: view
genes like me logo Genes that share phenotypes with ME1: view

Animal Model Products

miRNA for ME1 Gene

miRTarBase miRNAs that target ME1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ME1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ME1 Gene

Localization for ME1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ME1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ME1 Gene COMPARTMENTS Subcellular localization image for ME1 gene
Compartment Confidence
cytosol 4
chloroplast 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ME1: view

Pathways & Interactions for ME1 Gene

genes like me logo Genes that share pathways with ME1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Diabetes in human,mouse,rat

Gene Ontology (GO) - Biological Process for ME1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 8187880
GO:0006108 malate metabolic process IDA 7622060
GO:0006741 NADP biosynthetic process TAS 8187880
GO:0009725 response to hormone ISS --
GO:0009743 response to carbohydrate TAS 8187880
genes like me logo Genes that share ontologies with ME1: view

No data available for SIGNOR curated interactions for ME1 Gene

Drugs & Compounds for ME1 Gene

(9) Drugs for ME1 Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
phosphoenolpyruvate Experimental Pharma 0
NADH Nutra Target 0
malic acid Pharma Agonist, Activator 0

(8) Additional Compounds for ME1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
L-Malic acid
  • (-)-(S)-Malate
  • (-)-(S)-Malic acid
  • (-)-Hydroxysuccinate
  • (-)-Hydroxysuccinic acid
  • (-)-L-Malic acid
97-67-6
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with ME1: view

Transcripts for ME1 Gene

mRNA/cDNA for ME1 Gene

Unigene Clusters for ME1 Gene

Malic enzyme 1, NADP(+)-dependent, cytosolic:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ME1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ME1 Gene

No ASD Table

Relevant External Links for ME1 Gene

GeneLoc Exon Structure for
ME1
ECgene alternative splicing isoforms for
ME1

Expression for ME1 Gene

mRNA expression in normal human tissues for ME1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ME1 Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for ME1 Gene

This gene is overexpressed in Retina (15.6), Brain (6.4), and Nasopharynx (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ME1 Gene



SOURCE GeneReport for Unigene cluster for ME1 Gene Hs.21160

mRNA Expression by UniProt/SwissProt for ME1 Gene

P48163-MAOX_HUMAN
Tissue specificity: Expressed in all tissues tested including liver, placenta and white adipose tissue.
genes like me logo Genes that share expression patterns with ME1: view

Protein tissue co-expression partners for ME1 Gene

Primer Products

In Situ Assay Products

Orthologs for ME1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ME1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ME1 35
  • 91.33 (n)
  • 91.94 (a)
ME1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ME1 35
  • 92.31 (n)
  • 93.41 (a)
ME1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Me1 35
  • 86.54 (n)
  • 90.03 (a)
Me1 16
Me1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ME1 35
  • 99.77 (n)
  • 99.65 (a)
ME1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Me1 35
  • 86.42 (n)
  • 90.38 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ME1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ME1 35
  • 76.88 (n)
  • 77.84 (a)
ME1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ME1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia me1 35
  • 74.24 (n)
  • 77.64 (a)
Str.5724 35
zebrafish
(Danio rerio)
Actinopterygii me1 36
  • 68 (a)
OneToMany
ME1 (2 of 2) 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7848 37
  • 36 (a)
Mdh 37
  • 56 (a)
Men 37
  • 58 (a)
Menl-1 37
  • 47 (a)
Menl-2 37
  • 45 (a)
Men 35
  • 56.77 (n)
  • 59.04 (a)
CG7848 36
  • 31 (a)
ManyToMany
Men 36
  • 42 (a)
ManyToMany
Men-b 36
  • 50 (a)
ManyToMany
Menl-1 36
  • 41 (a)
ManyToMany
Menl-2 36
  • 39 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000184 35
  • 56.35 (n)
  • 61.17 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48B6A.12 37
  • 52 (a)
men-1 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAE1 36
  • 32 (a)
OneToMany
MAE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NADP-ME4 35
  • 57.24 (n)
  • 52.06 (a)
rice
(Oryza sativa)
Liliopsida Os.421 35
Os05g0186300 35
  • 54 (n)
  • 53.18 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7720 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03651 35
  • 50.19 (n)
  • 44.02 (a)
Species with no ortholog for ME1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ME1 Gene

ENSEMBL:
Gene Tree for ME1 (if available)
TreeFam:
Gene Tree for ME1 (if available)

Paralogs for ME1 Gene

Paralogs for ME1 Gene

genes like me logo Genes that share paralogs with ME1: view

Variants for ME1 Gene

Sequence variations from dbSNP and Humsavar for ME1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs750384 -- 83,320,703(+) AAATG(C/T)TACGT intron-variant
rs750385 -- 83,320,863(+) CAggt(A/G)agatg intron-variant
rs750386 -- 83,320,973(+) gggat(A/G)ggtta intron-variant
rs767144 -- 83,267,083(-) AATTA(A/C)CCTTC intron-variant
rs976065 -- 83,382,795(+) GAAGA(C/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ME1 Gene

Variant ID Type Subtype PubMed ID
esv1303011 CNV Deletion 17803354
esv2732363 CNV Deletion 23290073
esv1011019 CNV Insertion 20482838
esv2660285 CNV Deletion 23128226
esv2732364 CNV Deletion 23290073
nsv823766 CNV Gain 20364138

Variation tolerance for ME1 Gene

Residual Variation Intolerance Score: 46.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ME1 Gene

HapMap Linkage Disequilibrium report
ME1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ME1 Gene

Disorders for ME1 Gene

Relevant External Links for ME1

Genetic Association Database (GAD)
ME1
Human Genome Epidemiology (HuGE) Navigator
ME1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ME1
genes like me logo Genes that share disorders with ME1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ME1 Gene

Publications for ME1 Gene

  1. Studies on the protective effect of dietary fish oil on uranyl-nitrate-induced nephrotoxicity and oxidative damage in rat kidney. (PMID: 19931439) Priyamvada S. … Yusufi A.N. (Prostaglandins Leukot. Essent. Fatty Acids 2010) 23 67
  2. An RNA interference screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signature. (PMID: 20160030) Kourtidis A. … Conklin D.S. (Cancer Res. 2010) 23 67
  3. Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. (PMID: 20463879) Zhong H. … Schadt E.E. (PLoS Genet. 2010) 23 67
  4. NADP-dehydrogenases from pepper fruits: effect of maturation. (PMID: 19055545) Mateos R.M. … Corpas F.J. (Physiol Plant 2009) 23 67
  5. Alcohol sensitivity in Drosophila: translational potential of systems genetics. (PMID: 19652175) Morozova T.V. … Anholt R.R. (Genetics 2009) 23 67

Products for ME1 Gene

  • Addgene plasmids for ME1
  • Addgene plasmids for ME1

Sources for ME1 Gene

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