Aliases for ME1 Gene
External Ids for ME1 Gene
Previous GeneCards Identifiers for ME1 Gene
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
GeneCards Summary for ME1 Gene
ME1 (Malic Enzyme 1, NADP(+)-Dependent, Cytosolic) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include electron carrier activity and NAD binding. An important paralog of this gene is ME2.