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Aliases for MDP1 Gene

Aliases for MDP1 Gene

  • Magnesium-Dependent Phosphatase 1 2 3 5
  • Fructosamine-6-Phosphatase 2 3
  • MDP-1 3 4
  • EC 4
  • EC 3.1.3.- 4
  • FN6PASE 3

External Ids for MDP1 Gene

Previous GeneCards Identifiers for MDP1 Gene

  • GC14M023754
  • GC14M024683
  • GC14M004798

Summaries for MDP1 Gene

GeneCards Summary for MDP1 Gene

MDP1 (Magnesium-Dependent Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is NEDD8-MDP1.

UniProtKB/Swiss-Prot for MDP1 Gene

  • Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDP1 Gene

Genomics for MDP1 Gene

Regulatory Elements for MDP1 Gene

Enhancers for MDP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MDP1 on UCSC Golden Path with GeneCards custom track

Promoters for MDP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MDP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MDP1 Gene

24,213,937 bp from pter
24,216,070 bp from pter
2,134 bases
Minus strand

Genomic View for MDP1 Gene

Genes around MDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDP1 Gene

Proteins for MDP1 Gene

  • Protein details for MDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Magnesium-dependent phosphatase 1
    Protein Accession:
    Secondary Accessions:
    • Q86Y84
    • Q8NAD9

    Protein attributes for MDP1 Gene

    176 amino acids
    Molecular mass:
    20109 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MDP1 Gene

    Alternative splice isoforms for MDP1 Gene


neXtProt entry for MDP1 Gene

Proteomics data for MDP1 Gene at MOPED

Post-translational modifications for MDP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MDP1 Gene

No data available for DME Specific Peptides for MDP1 Gene

Domains & Families for MDP1 Gene

Gene Families for MDP1 Gene

Protein Domains for MDP1 Gene

Suggested Antigen Peptide Sequences for MDP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily.
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with MDP1: view

Function for MDP1 Gene

Molecular function for MDP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate and zinc, and slightly by calcium.
UniProtKB/Swiss-Prot Function:
Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

Enzyme Numbers (IUBMB) for MDP1 Gene

Gene Ontology (GO) - Molecular Function for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
genes like me logo Genes that share ontologies with MDP1: view

Phenotypes for MDP1 Gene

GenomeRNAi human phenotypes for MDP1:
genes like me logo Genes that share phenotypes with MDP1: view

Animal Model Products

miRNA for MDP1 Gene

miRTarBase miRNAs that target MDP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MDP1 Gene

Localization for MDP1 Gene

Subcellular locations from

Jensen Localization Image for MDP1 Gene COMPARTMENTS Subcellular localization image for MDP1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MDP1 Gene

Pathways & Interactions for MDP1 Gene

SuperPathways for MDP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MDP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MDP1 Gene

Drugs & Compounds for MDP1 Gene

(2) Drugs for MDP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Magnesium Nutra 0

(3) Additional Compounds for MDP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with MDP1: view

Transcripts for MDP1 Gene

Unigene Clusters for MDP1 Gene

Magnesium-dependent phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDP1 Gene

No ASD Table

Relevant External Links for MDP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MDP1 Gene

mRNA expression in normal human tissues for MDP1 Gene

Protein differential expression in normal tissues from HIPED for MDP1 Gene

This gene is overexpressed in Serum (24.9) and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MDP1 Gene

SOURCE GeneReport for Unigene cluster for MDP1 Gene Hs.220963

genes like me logo Genes that share expression patterns with MDP1: view

Protein tissue co-expression partners for MDP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MDP1 Gene

Orthologs for MDP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MDP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MDP-1 35
  • 86.09 (n)
  • 85.89 (a)
MDP-1 36
  • 85 (a)
(Canis familiaris)
Mammalia MDP1 35
  • 86.79 (n)
  • 88.41 (a)
(Mus musculus)
Mammalia Mdp1 35
  • 84.66 (n)
  • 84.66 (a)
Mdp1 16
Mdp1 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Mdp1 35
  • 84.66 (n)
  • 87.12 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
(Danio rerio)
Actinopterygii si:dkeyp-27c8.2 35
  • 54.99 (n)
  • 54.78 (a)
MDP1 36
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 30 (a)
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G14110 35
  • 51.54 (n)
  • 43.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07321 35
  • 52.48 (n)
  • 45.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP8B7.31 35
  • 49.66 (n)
  • 40.82 (a)
Species with no ortholog for MDP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDP1 Gene

Gene Tree for MDP1 (if available)
Gene Tree for MDP1 (if available)

Paralogs for MDP1 Gene

Paralogs for MDP1 Gene

(2) SIMAP similar genes for MDP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MDP1: view

Variants for MDP1 Gene

Variation tolerance for MDP1 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.47; 82.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MDP1 Gene

Disorders for MDP1 Gene

Relevant External Links for MDP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MDP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MDP1 Gene

Publications for MDP1 Gene

  1. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. (PMID: 16670083) Fortpied J. … Van Schaftingen E. (J. Biol. Chem. 2006) 2 3 23 67
  2. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. (PMID: 10889041) Selengut J.D. … Levine R.L. (Biochemistry 2000) 2 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for MDP1 Gene

Sources for MDP1 Gene