Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MDP1 Gene

Aliases for MDP1 Gene

  • Magnesium-Dependent Phosphatase 1 2 3
  • Fructosamine-6-Phosphatase 2 3
  • MDP-1 3 4
  • EC 4
  • EC 3.1.3.- 4
  • FN6PASE 3
  • SFTPB 6
  • SFTB3 6
  • S 6

External Ids for MDP1 Gene

Summaries for MDP1 Gene

GeneCards Summary for MDP1 Gene

MDP1 (Magnesium-Dependent Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is NEDD8-MDP1.

UniProtKB/Swiss-Prot for MDP1 Gene

  • Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDP1 Gene

Genomics for MDP1 Gene

Genomic Location for MDP1 Gene

24,213,937 bp from pter
24,216,070 bp from pter
2,134 bases
Minus strand

Genomic View for MDP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDP1 Gene

No data available for Regulatory Elements for MDP1 Gene

Proteins for MDP1 Gene

  • Protein details for MDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Magnesium-dependent phosphatase 1
    Protein Accession:
    Secondary Accessions:
    • Q86Y84
    • Q8NAD9

    Protein attributes for MDP1 Gene

    176 amino acids
    Molecular mass:
    20109 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MDP1 Gene

    Alternative splice isoforms for MDP1 Gene


neXtProt entry for MDP1 Gene

Proteomics data for MDP1 Gene at MOPED

Post-translational modifications for MDP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MDP1 Gene

No data available for DME Specific Peptides for MDP1 Gene

Domains for MDP1 Gene

Protein Domains for MDP1 Gene

Suggested Antigen Peptide Sequences for MDP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily.:
    • Q86V88
genes like me logo Genes that share domains with MDP1: view

No data available for Gene Families for MDP1 Gene

Function for MDP1 Gene

Molecular function for MDP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by vanadate and zinc, and slightly by calcium.
UniProtKB/Swiss-Prot Function: Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

Enzyme Numbers (IUBMB) for MDP1 Gene

Gene Ontology (GO) - Molecular Function for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding --
GO:0016791 phosphatase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MDP1: view

Phenotypes for MDP1 Gene

GenomeRNAi human phenotypes for MDP1:
genes like me logo Genes that share phenotypes with MDP1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MDP1 Gene

Localization for MDP1 Gene

Subcellular locations from

Jensen Localization Image for MDP1 Gene COMPARTMENTS Subcellular localization image for MDP1 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MDP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MDP1 Gene

Pathways for MDP1 Gene

SuperPathways for MDP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with MDP1: view

No data available for Pathways by source for MDP1 Gene

Compounds for MDP1 Gene

(3) HMDB Compounds for MDP1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Magnesium
  • NFB Orthophosphate
genes like me logo Genes that share compounds with MDP1: view

Transcripts for MDP1 Gene

Unigene Clusters for MDP1 Gene

Magnesium-dependent phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDP1 Gene

No ASD Table

Relevant External Links for MDP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MDP1 Gene

mRNA expression in normal human tissues for MDP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MDP1 Gene

SOURCE GeneReport for Unigene cluster for MDP1 Gene Hs.220963

genes like me logo Genes that share expressions with MDP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MDP1 Gene

Orthologs for MDP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MDP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MDP-1 35
  • 86.09 (n)
  • 85.89 (a)
MDP-1 36
  • 85 (a)
(Canis familiaris)
Mammalia MDP1 35
  • 86.79 (n)
  • 88.41 (a)
(Mus musculus)
Mammalia Mdp1 35
  • 84.66 (n)
  • 84.66 (a)
Mdp1 16
Mdp1 36
  • 84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Mdp1 35
  • 84.66 (n)
  • 87.12 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
(Danio rerio)
Actinopterygii MDP1 36
  • 54 (a)
si:dkeyp-27c8.2 35
  • 54.99 (n)
  • 54.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 30 (a)
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G14110 35
  • 51.54 (n)
  • 43.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07321 35
  • 52.48 (n)
  • 45.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP8B7.31 35
  • 49.66 (n)
  • 40.82 (a)
Species with no ortholog for MDP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDP1 Gene

Gene Tree for MDP1 (if available)
Gene Tree for MDP1 (if available)

Paralogs for MDP1 Gene

Paralogs for MDP1 Gene

Selected SIMAP similar genes for MDP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MDP1: view

Variants for MDP1 Gene

Relevant External Links for MDP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MDP1 Gene

Disorders for MDP1 Gene

(1) OMIM Diseases for MDP1 Gene (178640)

No disorders were found for MDP1 Gene.

No data available for UniProtKB/Swiss-Prot for MDP1 Gene

Publications for MDP1 Gene

  1. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. (PMID: 16670083) Fortpied J. … Van Schaftingen E. (J. Biol. Chem. 2006) 2 3 23
  2. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. (PMID: 10889041) Selengut J.D. … Levine R.L. (Biochemistry 2000) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MDP1 Gene

Sources for MDP1 Gene

Back to Top