Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MDP1 Gene

Aliases for MDP1 Gene

  • Magnesium Dependent Phosphatase 1 2 3 5
  • Fructosamine-6-Phosphatase 2 3
  • MDP-1 3 4
  • Magnesium-Dependent Phosphatase 1 3
  • EC 3.1.3.48 4
  • EC 3.1.3.- 4
  • FN6PASE 3

External Ids for MDP1 Gene

Previous GeneCards Identifiers for MDP1 Gene

  • GC14M023754
  • GC14M024683
  • GC14M004798

Summaries for MDP1 Gene

GeneCards Summary for MDP1 Gene

MDP1 (Magnesium Dependent Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is NEDD8-MDP1.

UniProtKB/Swiss-Prot for MDP1 Gene

  • Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDP1 Gene

Genomics for MDP1 Gene

Regulatory Elements for MDP1 Gene

Enhancers for MDP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G024422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -211.7 -211676 10.3 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CBLN3 KHNYN MDP1 NYNRIN ENSG00000259321 TINF2 ADCY4 NEDD8 NEDD8-MDP1 SDR39U1
GH14G024194 1.1 ENCODE 22.4 +20.2 20194 3.5 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 MDP1 REC8 NEDD8 NEDD8-MDP1 TINF2 PSME2 RNF31 PABPN1 TGM1 NFATC4
GH14G024230 1.1 ENCODE 18.4 -16.9 -16904 4.2 HDGF PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B MDP1 RNA5SP383 KHNYN LOC102724814 PABPN1 CIDEB HOMEZ TGM1 TM9SF1 DHRS4-AS1
GH14G024270 1.5 FANTOM5 ENCODE 10.9 -56.8 -56756 5.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 DHRS1 TINF2 LTB4R KHNYN NEDD8 NEDD8-MDP1 NOP9 GMPR2 CHMP4A ENSG00000254692
GH14G024277 1.4 FANTOM5 Ensembl ENCODE 11.1 -63.5 -63531 5.2 CTCF PKNOX1 USF1 NFIB MAX EBF1 RAD21 RELA RFX5 NFYB DHRS1 TINF2 NOP9 LTB4R2 CIDEB LTB4R NEDD8 NEDD8-MDP1 GMPR2 MDP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MDP1 on UCSC Golden Path with GeneCards custom track

Promoters for MDP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000273796 370 1001 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A

Genomic Location for MDP1 Gene

Chromosome:
14
Start:
24,213,937 bp from pter
End:
24,216,070 bp from pter
Size:
2,134 bases
Orientation:
Minus strand

Genomic View for MDP1 Gene

Genes around MDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDP1 Gene

Proteins for MDP1 Gene

  • Protein details for MDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V88-MGDP1_HUMAN
    Recommended name:
    Magnesium-dependent phosphatase 1
    Protein Accession:
    Q86V88
    Secondary Accessions:
    • Q86Y84
    • Q8NAD9

    Protein attributes for MDP1 Gene

    Size:
    176 amino acids
    Molecular mass:
    20109 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MDP1 Gene

    Alternative splice isoforms for MDP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDP1 Gene

Post-translational modifications for MDP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MDP1 Gene

No data available for DME Specific Peptides for MDP1 Gene

Domains & Families for MDP1 Gene

Gene Families for MDP1 Gene

Protein Domains for MDP1 Gene

Suggested Antigen Peptide Sequences for MDP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86V88

UniProtKB/Swiss-Prot:

MGDP1_HUMAN :
  • Belongs to the HAD-like hydrolase superfamily.
Family:
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with MDP1: view

Function for MDP1 Gene

Molecular function for MDP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate and zinc, and slightly by calcium.
UniProtKB/Swiss-Prot Function:
Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

Enzyme Numbers (IUBMB) for MDP1 Gene

Gene Ontology (GO) - Molecular Function for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MDP1: view

Phenotypes for MDP1 Gene

MGI mutant phenotypes for MDP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for MDP1:
genes like me logo Genes that share phenotypes with MDP1: view

Animal Models for MDP1 Gene

MGI Knock Outs for MDP1:
  • Mdp1 tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for MDP1 Gene

miRTarBase miRNAs that target MDP1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MDP1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDP1 Gene

Localization for MDP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MDP1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MDP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MDP1 Gene

Pathways & Interactions for MDP1 Gene

No Data Available

Interacting Proteins for MDP1 Gene

Gene Ontology (GO) - Biological Process for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with MDP1: view

No data available for Pathways by source and SIGNOR curated interactions for MDP1 Gene

Drugs & Compounds for MDP1 Gene

(4) Drugs for MDP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MDP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with MDP1: view

Transcripts for MDP1 Gene

Unigene Clusters for MDP1 Gene

Magnesium-dependent phosphatase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MDP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MDP1 Gene

No ASD Table

Relevant External Links for MDP1 Gene

GeneLoc Exon Structure for
MDP1
ECgene alternative splicing isoforms for
MDP1

Expression for MDP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MDP1 Gene

Protein differential expression in normal tissues from HIPED for MDP1 Gene

This gene is overexpressed in Serum (24.9) and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MDP1 Gene



Protein tissue co-expression partners for MDP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MDP1 Gene:

MDP1

SOURCE GeneReport for Unigene cluster for MDP1 Gene:

Hs.220963

Evidence on tissue expression from TISSUES for MDP1 Gene

  • Intestine(4.3)
  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MDP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MDP1 Gene

Orthologs for MDP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MDP1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MDP1 34
  • 86.79 (n)
cow
(Bos Taurus)
Mammalia MDP-1 35 34
  • 86.09 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Mdp1 34 16 35
  • 84.66 (n)
rat
(Rattus norvegicus)
Mammalia Mdp1 34
  • 84.66 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-27c8.2 34
  • 54.99 (n)
MDP1 35
  • 54 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 30 (a)
OneToMany
-- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G14110 34
  • 51.54 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07321 34
  • 52.48 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP8B7.31 34
  • 49.66 (n)
Species where no ortholog for MDP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDP1 Gene

ENSEMBL:
Gene Tree for MDP1 (if available)
TreeFam:
Gene Tree for MDP1 (if available)

Paralogs for MDP1 Gene

Paralogs for MDP1 Gene

(2) SIMAP similar genes for MDP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MDP1: view

Variants for MDP1 Gene

Sequence variations from dbSNP and Humsavar for MDP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs193921062 Uncertain significance 24,214,313(-) GCAAA(C/G)TGGGT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000169072 -- 24,213,821(+) TTGGG(A/G)TTGCC intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1000408551 -- 24,218,000(+) TAGAG(G/T)CTTCA intron-variant, upstream-variant-2KB
rs1003518970 -- 24,216,851(+) CAGAA(C/G)AAAGA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1004641002 -- 24,217,922(+) ATTTC(A/C)ATATA intron-variant, upstream-variant-2KB

Variation tolerance for MDP1 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.47; 82.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MDP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MDP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MDP1 Gene

Disorders for MDP1 Gene

Relevant External Links for MDP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MDP1

No disorders were found for MDP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MDP1 Gene

Publications for MDP1 Gene

  1. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. (PMID: 16670083) Fortpied J. … Van Schaftingen E. (J. Biol. Chem. 2006) 2 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. (PMID: 10889041) Selengut J.D. … Levine R.L. (Biochemistry 2000) 2 3 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for MDP1 Gene

Sources for MDP1 Gene

Content
Loading form....