MDP1 Gene
protein-coding GIFtS: 46
GCID: GC14M024683
|
|
magnesium-dependent phosphatase 1
| |
Aliases
for MDP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Magnesium-Dependent Phosphatase 11 2 | | EC 3.1.3.-3 | | MDP-12 3 | | EC 3.1.3.483 | | FN6Pase1 | | S5 | | MGC59871 | | SFTB35 | | FN6PASE2 | | SFTPB5 | | Fructosamine-6-Phosphatase1 | | |
Export aliases for MDP1 gene to outside databasesPrevious GC identifers: GC14M023754 GC14M004798 |
Summaries
for MDP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MGDP1_HUMAN, Q86V88Function: Magnesium-dependent phosphatase which may act as a tyrosine phosphatase (By similarity)
|
Genomic Views
for MDP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MDP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MDP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q12 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q12MDP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M024683: view genomic region
(about GC identifiers)
Start:
|
24,683,143 bp from pter |
End:
|
24,685,276 bp from pter |
Size:
|
2,134 bases |
Orientation:
|
minus strand |
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Proteins
for MDP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MGDP1_HUMAN, Q86V88 (See
protein sequence)Recommended Name: Magnesium-dependent phosphatase 1 Size: 176 amino acids; 20109 Da
Cofactor: Magnesium (By similarity)
1 PDB 3D structure from  and Proteopedia  for MDP1:2WM8 (3D)
Secondary accessions: Q86Y84 Q8NAD9Alternative splicing: 3 isoforms: Q86V88-1 Q86V88-2 Q86V88-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MDP1: NX_Q86V88
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86V88
MDP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186750.1 NP_001186751.1 NP_612485.2
ENSEMBL proteins: ENSP00000288087 ENSP00000380045
Human Recombinant Protein Products:
MDP1 Antibody Products:
Assay Products for MDP1: |
Protein
Domains /
Families
for MDP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MDP1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86V88ProtoNet protein and cluster: Q86V88 UniProtKB/Swiss-Prot: MGDP1_HUMAN, Q86V88Similarity: Belongs to the HAD-like hydrolase superfamily |
Function
for MDP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MGDP1_HUMAN, Q86V88Function: Magnesium-dependent phosphatase which may act as a tyrosine phosphatase (By similarity)Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateEnzyme regulation: Inhibited by vanadate and zinc, and slightly by calcium (By similarity)Enzyme Numbers (IUBMB): EC 3.1.3.481 EC 3.1.3.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MDP1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript Custom all cDNA clones Services for MDP1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDP1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
MDP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MDP1:
|
Pathways & Interactions
for MDP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MDP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for MDP1 (Q86V882, 3 ENSP000002880874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030389 | fructosamine metabolic process |
-- | -- |
MDP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MDP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MDP1
3 HMDB Compounds for MDP1 About this table
Search CenterWatch for drugs/clinical trials and news about MDP1 / MGDP1
|
Transcripts
for MDP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MDP1 gene (3 alternative transcripts): NM_001199821.1 NM_001199822.1 NM_138476.3 Unigene Cluster for MDP1: Magnesium-dependent phosphatase 1 Hs.220963 [show with all ESTs]Unigene Representative Sequence: BQ64691610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000288087 ENST00000530222 ENST00000396833 ENST00000532557 ENST00000531553
ENST00000525696 ENST00000533536 ENST00000532742 ENST00000528849 ENST00000466422
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MDP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MDP1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MDP1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MDP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDP1 |
Additional cDNA sequence: AK312038.1 BC046912.1 BC051382.1 18 DOTS entries: DT.313051 DT.95275589 DT.100696524 DT.120731565 DT.75196995 DT.97842298 DT.100782668 DT.455838 DT.100782666 DT.95225587 DT.95275587 DT.92420964 DT.100041981 DT.120731465 DT.40284385 DT.91915964 DT.99950778 DT.436722 24/554 AceView cDNA sequences (see all 554): BQ672031 BM840957 BQ949724 BM507263 BM768512 BF795492 BE312007 CB321698 CF130126 AI139663 BM842036 BQ056166 CD519487 BQ774333 BU192245 CF130271 AI354437 CB109528 AI700544 BP429915 AI085668 AJ710606 BQ632245 CD671413
GeneLoc Exon Structure
|
Expression
for MDP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MDP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGCGGCTAC
About this image
See MDP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MDP1
SOURCE GeneReport for Unigene cluster: Hs.220963
SABiosciences Custom PCR Arrays for MDP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MDP1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDP1 |
Orthologs
for MDP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MDP1 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkeyp-27c8.21 |
si:dkeyp-27c8.2 |
54.99(n)
54.78(a) |
|
557652 XM_680749.3 XP_685841.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
(YER134C)4
YER134C1 |
Magnesium-dependent acid phosphatase, member of the more4
hypothetical protein1 |
46.9(n)1
37.93(a)1 |
|
5(437803-437267)4
8568731, 4 NP_011060.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G141101 |
haloacid dehalogenase-like hydrolase domain-containing more |
51.3(n)
43.97(a) |
|
815897 NM_126983.3 NP_179027.2 |
rice
(Oryza sativa) |
Liliopsida |
Os03g07373001 |
hypothetical protein |
49.29(n)
43.57(a) |
|
4334038 NM_001057736.1 NP_001051201.1 |
ENSEMBL Gene Tree for MDP1 (if available)
TreeFam Gene Tree for MDP1 (if available) |
Paralogs
for MDP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MDP1 gene
- NEDD8-MDP12
2 SIMAP similar genes for MDP1 using alignment to 1 protein entry: MGDP1_HUMAN:MDP-1 NEDD8-MDP1
MDP1 for paralogs About GeneDecksing
|
Genomic Variants
for MDP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MDP1 (24683143 - 24685276 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MDP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MDP1 |
|
Disorders
/ Diseases
for MDP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MDP1 for disorders About GeneDecksing
OMIM gene information: 178640
OMIM disorders: 265120
1  disease for MDP1: About MalaCardstuberculosis
Export disorders for MDP1 gene to outside databases
|
Publications
for MDP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MDP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MDP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. (PubMed id 16670083)1, 3, 9 Fortpied J....Van Schaftingen E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- MDP-1: A novel eukaryotic magnesium-dependent phospha tase. (PubMed id 10889041)1, 3 Selengut J.D. and Levine R.L. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. (PubMed id 15461449)9 Peisach E....Allen K.N. (2004)
|
External Searches for MDP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MDP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MDP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MDP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MDP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MDP1 gene:
Search GeneIP for patents involving MDP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MDP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDP1 |
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