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Aliases for MDN1 Gene

Aliases for MDN1 Gene

  • MDN1, Midasin Homolog (Yeast) 2 3
  • MIDAS-Containing Protein 3 4
  • EC 2.4.2.18 64
  • EC 2.7.7.6 64
  • KIAA0301 4
  • EC 3.6.1 64
  • Midasin 3

External Ids for MDN1 Gene

Summaries for MDN1 Gene

GeneCards Summary for MDN1 Gene

MDN1 (MDN1, Midasin Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include ATPase activity and unfolded protein binding.

UniProtKB/Swiss-Prot for MDN1 Gene

  • Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.

Gene Wiki entry for MDN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDN1 Gene

Genomics for MDN1 Gene

Genomic Location for MDN1 Gene

Start:
89,642,499 bp from pter
End:
89,819,764 bp from pter
Size:
177,266 bases
Orientation:
Minus strand

Genomic View for MDN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDN1 Gene

Regulatory Elements for MDN1 Gene

Proteins for MDN1 Gene

  • Protein details for MDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NU22-MDN1_HUMAN
    Recommended name:
    Midasin
    Protein Accession:
    Q9NU22
    Secondary Accessions:
    • O15019
    • Q5T794

    Protein attributes for MDN1 Gene

    Size:
    5596 amino acids
    Molecular mass:
    632820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MDN1 Gene

Proteomics data for MDN1 Gene at MOPED

Selected DME Specific Peptides for MDN1 Gene

Post-translational modifications for MDN1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys100, Lys117, Lys366, Lys891, Lys1234, Lys1266, Lys1695, Lys1940, Lys3056, Lys3513, Lys4194, Lys4215, and Lys5541

Other Protein References for MDN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MDN1 Gene

UniProtKB/Swiss-Prot:

MDN1_HUMAN
Domain:
  • Contains 1 VWFA domain.:
    • Q9NU22
Family:
  • Belongs to the midasin family.:
    • Q9NU22
genes like me logo Genes that share domains with MDN1: view

No data available for Gene Families for MDN1 Gene

Function for MDN1 Gene

Molecular function for MDN1 Gene

UniProtKB/Swiss-Prot Function: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.

Enzyme Numbers (IUBMB) for MDN1 Gene

Gene Ontology (GO) - Molecular Function for MDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 21326211
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity NAS 12102729
GO:0051082 unfolded protein binding NAS 12102729
genes like me logo Genes that share ontologies with MDN1: view
genes like me logo Genes that share phenotypes with MDN1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MDN1 Gene

Localization for MDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDN1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MDN1 Gene COMPARTMENTS Subcellular localization image for MDN1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 12102729
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with MDN1: view

Pathways for MDN1 Gene

genes like me logo Genes that share pathways with MDN1: view

Pathways by source for MDN1 Gene

1 KEGG pathway for MDN1 Gene

Gene Ontology (GO) - Biological Process for MDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006461 protein complex assembly NAS 12102729
GO:0008152 metabolic process NAS 12102729
genes like me logo Genes that share ontologies with MDN1: view

Transcripts for MDN1 Gene

Unigene Clusters for MDN1 Gene

MDN1, midasin homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 49 ^ 50 ^ 51a · 51b ^ 52a · 52b ^ 53 ^ 54a · 54b ^ 55a · 55b ^ 56a · 56b ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62 ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 70a · 70b ^ 71a · 71b · 71c ^ 72a · 72b ^ 73a · 73b · 73c ^ 74 ^ 75a · 75b ^ 76 ^ 77 ^ 78 ^ 79 ^ 80 ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ·
SP1: - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: -
SP13:
SP14: - - -
SP15:
SP16:

Relevant External Links for MDN1 Gene

GeneLoc Exon Structure for
MDN1
ECgene alternative splicing isoforms for
MDN1

Expression for MDN1 Gene

mRNA expression in normal human tissues for MDN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MDN1 Gene

SOURCE GeneReport for Unigene cluster for MDN1 Gene Hs.529948

genes like me logo Genes that share expressions with MDN1: view

Orthologs for MDN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MDN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MDN1 36
  • 99.55 (n)
  • 99.32 (a)
MDN1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MDN1 36
  • 87.22 (n)
  • 87.82 (a)
MDN1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MDN1 36
  • 89.14 (n)
  • 89.61 (a)
MDN1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mdn1 36
  • 83.85 (n)
  • 82.76 (a)
Mdn1 16
Mdn1 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MDN1 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDN1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdn1 36
  • 82.53 (n)
  • 79.17 (a)
chicken
(Gallus gallus)
Aves MDN1 36
  • 69.85 (n)
  • 68.84 (a)
MDN1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MDN1 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25715 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mdn1 36
  • 64.33 (n)
  • 62.77 (a)
zebrafish
(Danio rerio)
Actinopterygii mdn1 36
  • 60.17 (n)
  • 57.63 (a)
mdn1 37
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007388 36
  • 47.13 (n)
  • 38.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13185 36
  • 47.47 (n)
  • 38.81 (a)
CG13185 37
  • 29 (a)
OneToOne
CG13185 38
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea F55F10.1 37
  • 27 (a)
OneToOne
F55F10.1 38
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDN1 37
  • 29 (a)
OneToOne
MDN1 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1043 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToOne
Species with no ortholog for MDN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MDN1 Gene

ENSEMBL:
Gene Tree for MDN1 (if available)
TreeFam:
Gene Tree for MDN1 (if available)

Paralogs for MDN1 Gene

Selected SIMAP similar genes for MDN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MDN1: view

No data available for Paralogs for MDN1 Gene

Variants for MDN1 Gene

Sequence variations from dbSNP and Humsavar for MDN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4783 -- 89,721,647(-) cactc(C/T)agctt intron-variant
rs15632 -- 89,721,656(-) AGGCC(A/G)CTGCA intron-variant
rs186040 -- 89,808,630(+) AACAC(C/T)CTTCC intron-variant
rs188356 -- 89,817,387(-) atatg(C/T)agtag intron-variant
rs192655 -- 89,808,559(+) AAGAA(A/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDN1 Gene

Variant ID Type Subtype PubMed ID
nsv886339 CNV Loss 21882294
nsv886340 CNV Loss 21882294
esv999488 CNV Deletion 20482838
esv2677421 CNV Deletion 23128226

Relevant External Links for MDN1 Gene

HapMap Linkage Disequilibrium report
MDN1
Human Gene Mutation Database (HGMD)
MDN1

Disorders for MDN1 Gene

Relevant External Links for MDN1

Genetic Association Database (GAD)
MDN1
Human Genome Epidemiology (HuGE) Navigator
MDN1
genes like me logo Genes that share disorders with MDN1: view

No data available for UniProtKB/Swiss-Prot for MDN1 Gene

Publications for MDN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein. (PMID: 12102729) Garbarino J.E. … Gibbons I.R. (BMC Genomics 2002) 2 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Identification of potential protein interactors of Lrrk2. (PMID: 17400507) DAochsel J.C. … Farrer M.J. (Parkinsonism Relat. Disord. 2007) 3

Products for MDN1 Gene

Sources for MDN1 Gene

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