Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MDN1 Gene

Aliases for MDN1 Gene

  • Midasin AAA ATPase 1 2 3 5
  • MIDAS-Containing Protein 3 4
  • MDN1, Midasin Homolog (Yeast) 2
  • MDN1, Midasin Homolog 3
  • EC 2.4.2.18 63
  • EC 2.7.7.6 63
  • KIAA0301 4
  • EC 3.6.1 63
  • Rea1 3

External Ids for MDN1 Gene

Previous GeneCards Identifiers for MDN1 Gene

  • GC06M090298
  • GC06M090348
  • GC06M090409
  • GC06M090352
  • GC06M087570

Summaries for MDN1 Gene

GeneCards Summary for MDN1 Gene

MDN1 (Midasin AAA ATPase 1) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include binding and unfolded protein binding.

UniProtKB/Swiss-Prot for MDN1 Gene

  • Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.

Gene Wiki entry for MDN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDN1 Gene

Genomics for MDN1 Gene

Regulatory Elements for MDN1 Gene

Promoters for MDN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MDN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MDN1 Gene

Chromosome:
6
Start:
89,642,499 bp from pter
End:
89,827,961 bp from pter
Size:
185,463 bases
Orientation:
Minus strand

Genomic View for MDN1 Gene

Genes around MDN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDN1 Gene

Proteins for MDN1 Gene

  • Protein details for MDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NU22-MDN1_HUMAN
    Recommended name:
    Midasin
    Protein Accession:
    Q9NU22
    Secondary Accessions:
    • O15019
    • Q5T794

    Protein attributes for MDN1 Gene

    Size:
    5596 amino acids
    Molecular mass:
    632820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MDN1 Gene

Proteomics data for MDN1 Gene at MOPED

Selected DME Specific Peptides for MDN1 Gene

Post-translational modifications for MDN1 Gene

  • Ubiquitination at Lys 100, Lys 117, Lys 366, Lys 891, Lys 1234, Lys 1266, Lys 1695, Lys 1940, Lys 3056, Lys 3513, Lys 4194, Lys 4215, and Lys 5541
  • Modification sites at PhosphoSitePlus

Other Protein References for MDN1 Gene

Domains & Families for MDN1 Gene

Gene Families for MDN1 Gene

Suggested Antigen Peptide Sequences for MDN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NU22

UniProtKB/Swiss-Prot:

MDN1_HUMAN :
  • Contains 1 VWFA domain.
  • Belongs to the midasin family.
Domain:
  • Contains 1 VWFA domain.
Family:
  • Belongs to the midasin family.
genes like me logo Genes that share domains with MDN1: view

Function for MDN1 Gene

Molecular function for MDN1 Gene

UniProtKB/Swiss-Prot Function:
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.

Enzyme Numbers (IUBMB) for MDN1 Gene

Gene Ontology (GO) - Molecular Function for MDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21326211
GO:0051082 unfolded protein binding NAS 12102729
genes like me logo Genes that share ontologies with MDN1: view
genes like me logo Genes that share phenotypes with MDN1: view

Animal Models for MDN1 Gene

MGI Knock Outs for MDN1:
  • Mdn1 tm1a(KOMP)Wtsi

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDN1 Gene

Localization for MDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDN1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MDN1 Gene COMPARTMENTS Subcellular localization image for MDN1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 3
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MDN1 Gene

Pathways & Interactions for MDN1 Gene

genes like me logo Genes that share pathways with MDN1: view

Pathways by source for MDN1 Gene

1 KEGG pathway for MDN1 Gene

Gene Ontology (GO) - Biological Process for MDN1 Gene

None

No data available for SIGNOR curated interactions for MDN1 Gene

Drugs & Compounds for MDN1 Gene

No Compound Related Data Available

Transcripts for MDN1 Gene

Unigene Clusters for MDN1 Gene

MDN1, midasin homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 49 ^ 50 ^ 51a · 51b ^ 52a · 52b ^ 53 ^ 54a · 54b ^ 55a · 55b ^ 56a · 56b ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62 ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 70a · 70b ^ 71a · 71b · 71c ^ 72a · 72b ^ 73a · 73b · 73c ^ 74 ^ 75a · 75b ^ 76 ^ 77 ^ 78 ^ 79 ^ 80 ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ·
SP1: - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: -
SP13:
SP14: - - -
SP15:
SP16:

Relevant External Links for MDN1 Gene

GeneLoc Exon Structure for
MDN1
ECgene alternative splicing isoforms for
MDN1

Expression for MDN1 Gene

mRNA expression in normal human tissues for MDN1 Gene

Protein differential expression in normal tissues from HIPED for MDN1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (18.2) and Urine (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MDN1 Gene



SOURCE GeneReport for Unigene cluster for MDN1 Gene Hs.529948

genes like me logo Genes that share expression patterns with MDN1: view

Protein tissue co-expression partners for MDN1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MDN1 Gene

Orthologs for MDN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MDN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MDN1 35
  • 99.55 (n)
  • 99.32 (a)
MDN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MDN1 36
  • 87 (a)
OneToOne
MDN1 35
  • 87.22 (n)
  • 87.82 (a)
dog
(Canis familiaris)
Mammalia MDN1 35
  • 89.14 (n)
  • 89.61 (a)
MDN1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mdn1 16
Mdn1 36
  • 81 (a)
OneToOne
Mdn1 35
  • 83.85 (n)
  • 82.76 (a)
oppossum
(Monodelphis domestica)
Mammalia MDN1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDN1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdn1 35
  • 82.53 (n)
  • 79.17 (a)
chicken
(Gallus gallus)
Aves MDN1 36
  • 68 (a)
OneToOne
MDN1 35
  • 69.85 (n)
  • 68.84 (a)
lizard
(Anolis carolinensis)
Reptilia MDN1 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25715 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mdn1 35
  • 64.33 (n)
  • 62.77 (a)
zebrafish
(Danio rerio)
Actinopterygii mdn1 36
  • 55 (a)
OneToOne
mdn1 35
  • 60.17 (n)
  • 57.63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007388 35
  • 47.13 (n)
  • 38.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13185 36
  • 29 (a)
OneToOne
CG13185 37
  • 32 (a)
CG13185 35
  • 47.47 (n)
  • 38.81 (a)
worm
(Caenorhabditis elegans)
Secernentea F55F10.1 36
  • 27 (a)
OneToOne
F55F10.1 37
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDN1 36
  • 29 (a)
OneToOne
MDN1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1043 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for MDN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MDN1 Gene

ENSEMBL:
Gene Tree for MDN1 (if available)
TreeFam:
Gene Tree for MDN1 (if available)

Paralogs for MDN1 Gene

(1) SIMAP similar genes for MDN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MDN1: view

No data available for Paralogs for MDN1 Gene

Variants for MDN1 Gene

Sequence variations from dbSNP and Humsavar for MDN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4707569 - 89,787,870(+) AAAAA(A/C)CTGAA nc-transcript-variant, reference, missense
rs4140446 - 89,738,373(+) TATGA(C/T)TGATG nc-transcript-variant, reference, missense
VAR_024236 -
rs12110451 - 89,772,678(+) CTCGA(A/C/T)GAGAA nc-transcript-variant, reference, missense
rs34764513 - 89,751,527(-) GATTG(C/T)GGTGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MDN1 Gene

Variant ID Type Subtype PubMed ID
nsv886339 CNV Loss 21882294
nsv886340 CNV Loss 21882294
esv999488 CNV Deletion 20482838
esv2677421 CNV Deletion 23128226

Variation tolerance for MDN1 Gene

Residual Variation Intolerance Score: 4.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.90; 98.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MDN1 Gene

HapMap Linkage Disequilibrium report
MDN1
Human Gene Mutation Database (HGMD)
MDN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDN1 Gene

Disorders for MDN1 Gene

Relevant External Links for MDN1

Genetic Association Database (GAD)
MDN1
Human Genome Epidemiology (HuGE) Navigator
MDN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MDN1

No disorders were found for MDN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MDN1 Gene

Publications for MDN1 Gene

  1. Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein. (PMID: 12102729) Garbarino J.E. … Gibbons I.R. (BMC Genomics 2002) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3

Products for MDN1 Gene

Sources for MDN1 Gene

Back to Top

Content