Aliases for MDN1 Gene
External Ids for MDN1 Gene
Previous GeneCards Identifiers for MDN1 Gene
GeneCards Summary for MDN1 Gene
MDN1 (Midasin AAA ATPase 1) is a Protein Coding gene. Diseases associated with MDN1 include Bone Ewing's Sarcoma. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include binding and unfolded protein binding.
UniProtKB/Swiss-Prot for MDN1 Gene
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).