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MDN1 Gene

protein-coding   GIFtS: 57
GCID: GC06M090352

MDN1, Midasin Homolog (Yeast)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MDN1, Midasin Homolog (Yeast)1 2     EC 2.4.2.188
MIDAS-Containing Protein2 3     EC 2.7.7.68
midasin2     EC 3.6.18
KIAA03013     

External Ids:    HGNC: 183021   Entrez Gene: 231952   Ensembl: ENSG000001121597   UniProtKB: Q9NU223   

Export aliases for MDN1 gene to outside databases

Previous GC identifers: GC06M090298 GC06M090348 GC06M090409 GC06M087570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MDN1 Gene:
MDN1 (MDN1, midasin homolog (yeast)) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and ATPase activity.

UniProtKB/Swiss-Prot: MDN1_HUMAN, Q9NU22
Function: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By
similarity)

Gene Wiki entry for MDN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MDN1 gene promoter:
         Nkx5-1   Tal-1beta   Roaz   Arnt   HNF-1A   HNF-1   TGIF   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMDN1 promoter sequence
   Search Chromatin IP Primers for MDN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MDN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

MDN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDN1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M090352:  view genomic region     (about GC identifiers)

Start:
90,352,218 bp from pter      End:
90,529,442 bp from pter
Size:
177,225 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MDN1_HUMAN, Q9NU22 (See protein sequence)
Recommended Name: Midasin  
Size: 5596 amino acids; 632820 Da
Secondary accessions: O15019 Q5T794

Explore the universe of human proteins at neXtProt for MDN1: NX_Q9NU22

Explore proteomics data for MDN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys100, Lys117, Lys366, Lys891, Lys1234, Lys1266, Lys1695, Lys1940, Lys3056, Lys3513,
                                 Lys4194, Lys4215, Lys5541
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for MDN1 (Q9NU22)
     PCRSSLV  GDTGCGK  LDEISLA 


    See MDN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055426.1  
    ENSEMBL proteins: 
     ENSP00000358400   ENSP00000469327   ENSP00000409664   ENSP00000413970  

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    Cloud-Clone Corp. Proteins for MDN1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011704 ATPase_dyneun-rel_AAA
     IPR027417 P-loop_NTPase
     IPR012099 Midasin
     IPR003593 AAA+_ATPase
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9NU22

    ProtoNet protein and cluster: Q9NU22

    2 Blocks protein domains:
    IPB002035 Von Willebrand factor type A domain signature
    IPB011704 ATPase associated with various cellular activities


    UniProtKB/Swiss-Prot: MDN1_HUMAN, Q9NU22
    Similarity: Belongs to the midasin family
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with MDN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDN1_HUMAN, Q9NU22
    Function: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By
    similarity)

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 2.7.7.62 EC 2.4.2.182

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity NAS12102729
         
    Find genes that share ontologies with MDN1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MDN1:
     Decreased Tat-dependent transc  Nuclear 60S biogenesis defects  Synthetic lethal with c-Myc af  Wnt reporter downregulated 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mdn1):
     immune system  mortality/aging 

    Find genes that share phenotypes with MDN1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MDN1

    miRNA
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    miRTarBase miRNAs that target MDN1:
    hsa-mir-484 (MIRT041859), hsa-mir-92a-3p (MIRT049165), hsa-mir-186-5p (MIRT045292), hsa-mir-222-3p (MIRT046580), hsa-mir-642a-5p (MIRT039573), hsa-mir-16-5p (MIRT031497), hsa-mir-1260b (MIRT052773)

    Block miRNA regulation of human, mouse, rat MDN1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MDN1:
    hsa-miR-204 hsa-miR-3714 hsa-miR-4287 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidMDN1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MDN1_HUMAN, Q9NU22: Nucleus (By similarity). Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane3
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS12102729
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with MDN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MDN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with MDN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MDN1):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MDN1
    Interactions:

        Search GeneGlobe Interaction Network for MDN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MDN1 (Q9NU221, 2, 3 ENSP000003584004) via UniProtKB, MINT, STRING, and/or I2D (see all 932)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=4 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process NAS12102729
    GO:0006461protein complex assembly NAS12102729

    Find genes that share ontologies with MDN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MDN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MDN1 gene: 
    NM_014611.2  

    Unigene Cluster for MDN1:

    MDN1, midasin homolog (yeast)
    Hs.529948  [show with all ESTs]
    Unigene Representative Sequence: AF503925
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369393(uc003pnn.1) ENST00000487831 ENST00000468568 ENST00000439638
    ENST00000428876(uc003pno.1 uc003pnp.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat MDN1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MDN1:
    hsa-miR-204 hsa-miR-3714 hsa-miR-4287 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidMDN1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MDN1
    Predesigned siRNA for gene silencing in human, mouse, rat MDN1
    Clone
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    GenScript: all cDNA clones in your preferred vector: MDN1 (NM_014611)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDN1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MDN1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MDN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MDN1
      QuantiTect SYBR Green Assays in human, mouse, rat MDN1
      QuantiFast Probe-based Assays in human, mouse, rat MDN1

    Additional mRNA sequence: 

    AB002299.2 AF503925.1 AK027048.1 AK098453.1 AK123109.1 AK124025.1 AK125181.1 BC014882.2 
    BC020432.1 BC036888.1 CR627399.1 

    20 DOTS entries:

    DT.416515  DT.91748145  DT.95098521  DT.99974319  DT.40208140  DT.205489  DT.40254890  DT.95271645 
    DT.121383974  DT.86841154  DT.100008614  DT.100666849  DT.100789301  DT.100789302  DT.102838109  DT.65286765 
    DT.75103782  DT.91983044  DT.95257456  DT.95271643 

    Selected AceView cDNA sequences (see all 235):

    CK300312 CR621075 BQ962883 BG942924 AI990003 AI633939 BQ073374 BQ287975 
    AI926632 AU125556 CB321776 NM_014611 BQ437357 AL138276 BE792924 BG256237 
    BX500874 AK124025 BM469521 BF195855 BQ417433 CD671359 BQ923756 AB002299 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MDN1 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                          -                                                                                 
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 49 ^ 50 ^ 51a · 51b ^ 52a · 52b ^ 53 ^ 54a · 54b ^ 55a · 55b ^ 56a · 56b ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62 ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^
    SP1:  -                       -                                                                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 70a · 70b ^ 71a · 71b · 71c ^ 72a · 72b ^ 73a · 73b · 73c ^ 74 ^ 75a · 75b ^ 76 ^ 77 ^ 78 ^ 79 ^ 80 ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ·
    SP1:  -           -                 -                                   -                                                                       -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MDN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MDN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MDN1 Expression
    About this image

    MDN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MDN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529948
        Custom PCR Arrays for MDN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MDN1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mdn11 , 5 midasin homolog (yeast)1, 5 83.85(n)1
    82.76(a)1
      4 (14.30 cM)5
    1000191  NM_001081392.11  NP_001074861.11 
     326571195 
    chicken
    (Gallus gallus)
    Aves MDN11 MDN1, midasin homolog (yeast) 69.85(n)
    68.84(a)
      421811  XM_004940387.1  XP_004940444.1 
    lizard
    (Anolis carolinensis)
    Reptilia MDN16
    MDN1, midasin homolog (yeast)
    66(a)
    1 ↔ 1
    1(174677045-174809187)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257152 Xenopus laevis transcribed sequence with weak similarity more 76(n)    BJ084735.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mdn11 midasin homolog (yeast) 60.17(n)
    57.63(a)
      555704  XM_003200703.2  XP_003200751.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG131851 , 3 CG131851 32(a)3
    47.47(n)1
    38.81(a)1
      362681  NM_001103809.21  NP_001097279.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F55F10.13   -- 38(a)   IV(4361048-4386449)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDN1(YLR106C)4 Huge dynein-related AAA-type ATPase (midasin), forms more   --   12(363738-349006) 850796  NP_013207.1 


    ENSEMBL Gene Tree for MDN1 (if available)
    TreeFam Gene Tree for MDN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MDN1 gene
    1 SIMAP similar gene for MDN1 using alignment to 4 protein entries:     MDN1_HUMAN (see all proteins):
    DKFZp686H16106

    Find genes that share paralogs with MDN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MDN1 (see all 3973)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557665361,2
    C--87714027(+) AAAAA-/A/AA  
            
    GTAAC
    1 -- int11NA 2
    rs1893180001,2
    --90352791(+) CCAAGC/TAAAAA 1 -- ds50010--------
    rs94512581,2
    H--90352828(+) TGGAAA/TAAATA 1 -- ds50014Minor allele frequency- T:0.00NS EA 414
    rs76821,2
    C,F,H--90352862(-) AGAAAC/TGCTGT 1 -- ds5001 ese310Minor allele frequency- T:0.05MN EA NS NA WA 2324
    rs3707567311,2
    C--90352932(+) TTGAC-/TGTT  
            
    TGTTA
    1 -- ds50010--------
    rs1390903031,2
    --90353208(+) TCACAA/GTAAGA 1 -- ds50010--------
    rs1808051521,2
    --90353352(+) GGACTA/GTCAGA 1 -- ut310--------
    rs1427141151,2
    C--90353370(+) CTCCT-/GGGCAG 1 -- ut310--------
    rs1499407081,2
    C--90353383(+) TCTCCG/TCAAGG 1 -- ut310--------
    rs1861852871,2
    --90353478(+) CAAGGC/TAGGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MDN1 (90352218 - 90529442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MDN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999488CNV Deletion20482838
    esv2677421CNV Deletion23128226
    nsv886339CNV Loss21882294
    nsv886340CNV Loss21882294

    Human Gene Mutation Database (HGMD): MDN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MDN1
    DNA2.0 Custom Variant and Variant Library Synthesis for MDN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with MDN1           About GenesLikeMe

    Genetic Association Database (GAD): MDN1
    Human Genome Epidemiology (HuGE) Navigator: MDN1 (2 documents)

    Export disorders for MDN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MDN1 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with MDN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein. (PubMed id 12102729)1, 2, 3 Garbarino J.E. and Gibbons I.R. (BMC Genomics 2002)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    6. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23195 HGNC: 18302 AceView: MDN1 Ensembl:ENSG00000112159 euGenes: HUgn23195
    ECgene: MDN1 Kegg: 23195 H-InvDB: MDN1

    (According to HUGE)
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    HUGE: KIAA0301

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MDN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MDN1 gene:
    Search GeneIP for patents involving MDN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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