Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MDN1 Gene

protein-coding   GIFtS: 56
GCID: GC06M090352

MDN1, Midasin Homolog (Yeast)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MDN1, Midasin Homolog (Yeast)1 2     EC 2.4.2.188
MIDAS-Containing Protein2 3     EC 2.7.7.68
midasin2     EC 3.6.18
KIAA03013     

External Ids:    HGNC: 183021   Entrez Gene: 231952   Ensembl: ENSG000001121597   UniProtKB: Q9NU223   

Export aliases for MDN1 gene to outside databases

Previous GC identifers: GC06M090298 GC06M090348 GC06M090409 GC06M087570


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MDN1 Gene: 
MDN1 (MDN1, midasin homolog (yeast)) is a protein-coding gene. Diseases associated with MDN1 include fanconi's anemia, and anemia. GO annotations related to this gene include unfolded protein binding and ATPase activity.

UniProtKB/Swiss-Prot: MDN1_HUMAN, Q9NU22
Function: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By
similarity)

Gene Wiki entry for MDN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MDN1 gene promoter:
         Nkx5-1   Tal-1beta   Roaz   Arnt   HNF-1A   HNF-1   TGIF   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMDN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MDN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

MDN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDN1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M090352:  view genomic region     (about GC identifiers)

Start:
90,352,218 bp from pter      End:
90,529,442 bp from pter
Size:
177,225 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MDN1_HUMAN, Q9NU22 (See protein sequence)
Recommended Name: Midasin  
Size: 5596 amino acids; 632820 Da
Subcellular location: Nucleus (By similarity). Nucleus, nucleolus
Secondary accessions: O15019 Q5T794

Explore the universe of human proteins at neXtProt for MDN1: NX_Q9NU22

Explore proteomics data for MDN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NU22

  • 3 DME Specific Peptides for MDN1 (Q9NU22)
     PCRSSLV  GDTGCGK  LDEISLA 

    MDN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MDN1 Protein Expression
    REFSEQ proteins: NP_055426.1  
    ENSEMBL proteins: 
     ENSP00000358400   ENSP00000469327   ENSP00000409664   ENSP00000413970  

    Human Recombinant Protein Products for MDN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MDN1
    GenScript Custom Purified and Recombinant Proteins Services for MDN1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MDN1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS12102729
    GO:0005730nucleolus IEA--

    MDN1 for ontologies           About GeneDecksing



    MDN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MDN1
    GenScript Custom Superior Antibodies Services for MDN1
    Novus Biologicals MDN1 Antibodies
    Search for Antibodies for MDN1 at Abcam
    Cloud-Clone Corp. Antibodies for MDN1 
    Search ThermoFisher Antibodies for MDN1
    Search LSBio for Antibodies for MDN1 

    Assay Products for MDN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MDN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MDN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MDN1 
    Cloud-Clone Corp. CLIAs for MDN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011704 ATPase_dyneun-rel_AAA
     IPR027417 P-loop_NTPase
     IPR012099 Midasin
     IPR003593 AAA+_ATPase
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9NU22

    ProtoNet protein and cluster: Q9NU22

    2 Blocks protein domains:
    IPB002035 Von Willebrand factor type A domain signature
    IPB011704 ATPase associated with various cellular activities


    UniProtKB/Swiss-Prot: MDN1_HUMAN, Q9NU22
    Similarity: Belongs to the midasin family
    Similarity: Contains 1 VWFA domain


    MDN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDN1_HUMAN, Q9NU22
    Function: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By
    similarity)

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 2.7.7.62 EC 2.4.2.182

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity NAS12102729
         
    MDN1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MDN1:
     Decreased Tat-dependent transc  Nuclear 60S biogenesis defects  Synthetic lethal with c-Myc af  Wnt reporter downregulated 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mdn1):
     immune system  mortality/aging 

    MDN1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MDN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MDN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MDN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MDN1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDN1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MDN1:
    hsa-miR-204 hsa-miR-3714 hsa-miR-4287 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidMDN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MDN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MDN1


    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MDN1 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MDN1 (NM_014611)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDN1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MDN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MDN1
    Search LifeMap BioReagents cell lines for MDN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MDN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MDN1):
        Ribosome biogenesis in eukaryotes


    MDN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MDN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/893 Interacting proteins for MDN1 (Q9NU222, 3 ENSP000003584004) via UniProtKB, MINT, STRING, and/or I2D (see all 893)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process NAS12102729
    GO:0006461protein complex assembly NAS12102729

    MDN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MDN1

    Search CenterWatch for drugs/clinical trials and news about MDN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MDN1 gene: 
    NM_014611.1  

    Unigene Cluster for MDN1:

    MDN1, midasin homolog (yeast)
    Hs.529948  [show with all ESTs]
    Unigene Representative Sequence: AF503925
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369393(uc003pnn.1) ENST00000487831 ENST00000468568 ENST00000439638
    ENST00000428876(uc003pno.1 uc003pnp.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDN1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MDN1:
    hsa-miR-204 hsa-miR-3714 hsa-miR-4287 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidMDN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MDN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDN1
    Clone
    Products:
         
    OriGene clones in human, mouse for MDN1 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MDN1 (NM_014611)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDN1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MDN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MDN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MDN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDN1

    Additional mRNA sequence: 

    AB002299.2 AF503925.1 AK027048.1 AK098453.1 AK123109.1 AK124025.1 AK125181.1 BC014882.2 
    BC020432.1 BC036888.1 CR627399.1 

    20 DOTS entries:

    DT.416515  DT.91748145  DT.95098521  DT.99974319  DT.40208140  DT.205489  DT.40254890  DT.95271645 
    DT.121383974  DT.86841154  DT.100008614  DT.100666849  DT.100789301  DT.100789302  DT.102838109  DT.65286765 
    DT.75103782  DT.91983044  DT.95257456  DT.95271643 

    24/235 AceView cDNA sequences (see all 235):

    BF195855 AI990003 BG942924 BX500874 BG681903 BE783093 C04730 BE858085 
    AI424987 AK124025 BM469521 CK300312 AI133682 BE792924 BG256237 AI633939 
    AL135200 AA369698 BM803283 AK125181 BM977350 AF503925 AU125556 CR627399 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MDN1 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                          -                                                                                 
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 49 ^ 50 ^ 51a · 51b ^ 52a · 52b ^ 53 ^ 54a · 54b ^ 55a · 55b ^ 56a · 56b ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62 ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^
    SP1:  -                       -                                                                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 70a · 70b ^ 71a · 71b · 71c ^ 72a · 72b ^ 73a · 73b · 73c ^ 74 ^ 75a · 75b ^ 76 ^ 77 ^ 78 ^ 79 ^ 80 ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ·
    SP1:  -           -                 -                                   -                                                                       -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MDN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MDN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MDN1 Expression
    About this image


    See MDN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MDN1

    SOURCE GeneReport for Unigene cluster: Hs.529948
        SABiosciences Custom PCR Arrays for MDN1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MDN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MDN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MDN1 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mdn11 , 5 midasin homolog (yeast)1, 5 83.96(n)1
    82.92(a)1
      4 (14.30 cM)5
    1000191  NM_001081392.11  NP_001074861.11 
     326571195 
    chicken
    (Gallus gallus)
    Aves MDN11 MDN1, midasin homolog (yeast) 69.82(n)
    68.97(a)
      421811  XM_419835.3  XP_419835.3 
    lizard
    (Anolis carolinensis)
    Reptilia MDN16
    MDN1, midasin homolog (yeast)
    66(a)
    1 ↔ 1
    1(174677045-174809187)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257152 Xenopus laevis transcribed sequence with weak similarity more 76(n)    BJ084735.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mdn11 midasin homolog (yeast) 60.25(n)
    57.91(a)
      555704  XM_003200703.1  XP_003200751.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG131851 , 3 CG131851 32(a)3
    46.94(n)1
    38.36(a)1
      362681  NM_001103809.11  NP_001097279.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F55F10.13   -- 38(a)   IV(4361048-4386449)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDN1(YLR106C)4
    MDN11
    Huge dynein-related AAA-type ATPase (midasin), forms more4
    Mdn1p1
    47.92(n)1
    38.44(a)1
      12(363738-349006)4
    8507961, 4  NP_013207.11, 4 


    ENSEMBL Gene Tree for MDN1 (if available)
    TreeFam Gene Tree for MDN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MDN1 gene
    1 SIMAP similar gene for MDN1 using alignment to 4 protein entries:     MDN1_HUMAN (see all proteins):
    DKFZp686H16106

    MDN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3973 SNPs in MDN1 are shown (see all 3973)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557665361,2
    C--87714027(+) AAAAA-/A/AA  
            
    GTAAC
    1 -- int11NA 2
    rs1893180001,2
    --90352791(+) CCAAGC/TAAAAA 1 -- ds50010--------
    rs94512581,2
    H--90352828(+) TGGAAA/TAAATA 1 -- ds50014Minor allele frequency- T:0.00NS EA 414
    rs76821,2
    C,F,H--90352862(-) AGAAAC/TGCTGT 1 -- ds5001 ese310Minor allele frequency- T:0.05MN EA NS NA WA 2324
    rs3707567311,2
    C--90352932(+) TTGAC-/TGTT  
            
    TGTTA
    1 -- ds50010--------
    rs1390903031,2
    --90353208(+) TCACAA/GTAAGA 1 -- ds50010--------
    rs1808051521,2
    --90353352(+) GGACTA/GTCAGA 1 -- ut310--------
    rs1427141151,2
    C--90353370(+) CTCCT-/GGGCAG 1 -- ut310--------
    rs1499407081,2
    C--90353383(+) TCTCCG/TCAAGG 1 -- ut310--------
    rs1861852871,2
    --90353478(+) CAAGGC/TAGGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MDN1 (90352218 - 90529442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MDN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv999488CNV Deletion20482838
    esv2677421CNV Deletion23128226
    nsv886339CNV Loss21882294
    nsv886340CNV Loss21882294


    Human Gene Mutation Database (HGMD): MDN1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MDN1
    DNA2.0 Custom Variant and Variant Library Synthesis for MDN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for MDN1:    About MalaCards
    fanconi's anemia    anemia


    MDN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MDN1
    Human Genome Epidemiology (HuGE) Navigator: MDN1 (2 documents)

    Export disorders for MDN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MDN1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with MDN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein. (PubMed id 12102729)1, 2, 3 Garbarino J.E. and Gibbons I.R. (2002)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    7. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    9. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23195 HGNC: 18302 AceView: MDN1 Ensembl:ENSG00000112159 euGenes: HUgn23195
    ECgene: MDN1 Kegg: 23195 H-InvDB: MDN1

    (According to HUGE)
    About This Section
    HUGE: KIAA0301

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MDN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MDN1 gene:
    Search GeneIP for patents involving MDN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MDN1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MDN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MDN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MDN1   OriGene Custom Protein Services for MDN1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MDN1
     QIAGEN SeqTarget long-range PCR primers for resequencing MDN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDN1
     GenScript Custom Purified and Recombinant Proteins Services for MDN1 GenScript cDNA clones with any tag delivered in your preferred vector for MDN1
     GenScript Custom Assay Services for MDN1 GenScript Custom Superior Antibodies Services for MDN1
     GenScript Custom overexpressing Cell Line Services for MDN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MDN1 promoter
     Search Chromatin IP Primers for MDN1
     RT2 qPCR Primer Assay in human, mouse, rat MDN1
     Search GNC Networks for MDN1
     SABiosciences Custom PCR Arrays for MDN1
     Search Tocris compounds for MDN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MDN1 antibodies
     Search for Antibodies for MDN1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MDN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MDN1
     Antibodies for MDN1
     ELISAs for MDN1
     CLIAs for MDN1
     Search LifeMap BioReagents cell lines for MDN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDN1
     SwitchGear 3'UTR luciferase reporter plasmids for MDN1
     SwitchGear Promoter luciferase reporter plasmids for MDN1
     Search ThermoFisher Antibodies for MDN1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MDN1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MDN1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MDN1
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression
     Search LSBio for Antibodies for MDN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MDN1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4