Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MDM4 Gene

Aliases for MDM4 Gene

  • MDM4, P53 Regulator 2 3 5
  • Mdm2-Like P53-Binding Protein 3 4
  • Protein Mdmx 3 4
  • MDMX 3 4
  • Mdm4, Transformed 3T3 Cell Double Minute 4, P53 Binding Protein (Mouse) 2
  • Mouse Double Minute 4, Human Homolog Of; P53-Binding Protein 2
  • Double Minute 4, Human Homolog Of; P53-Binding Protein 3
  • Mdm4 P53 Binding Protein Homolog (Mouse) 2
  • Mdm4 P53 Binding Protein Homolog 3
  • P53-Binding Protein Mdm4 4
  • Double Minute 4 Protein 4
  • MDM4 Protein Variant G 3
  • MDM4 Protein Variant Y 3
  • MDM4-Related Protein 1 3
  • Protein Mdm4 3
  • MRP1 3
  • HDMX 3

External Ids for MDM4 Gene

Previous GeneCards Identifiers for MDM4 Gene

  • GC01P202211
  • GC01P199946
  • GC01P200846
  • GC01P201662
  • GC01P201629
  • GC01P201217
  • GC01P202752
  • GC01P204486
  • GC01P175650

Summaries for MDM4 Gene

Entrez Gene Summary for MDM4 Gene

  • This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MDM4 Gene

MDM4 (MDM4, P53 Regulator) is a Protein Coding gene. Diseases associated with MDM4 include Intraocular Retinoblastoma and Familial Retinoblastoma. Among its related pathways are ATM Pathway and DNA damage response. GO annotations related to this gene include enzyme binding. An important paralog of this gene is MDM2.

UniProtKB/Swiss-Prot for MDM4 Gene

  • Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Gene Wiki entry for MDM4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDM4 Gene

Genomics for MDM4 Gene

Regulatory Elements for MDM4 Gene

Enhancers for MDM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F204511 1.6 FANTOM5 ENCODE 64.9 +0.7 702 11.9 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 MDM4 ZBED6 GYG2P2 SNRPE PPP1R15B PIK3C2B LOC101929459 ENSG00000236108 LOC105371691 RBBP5
GH01F204415 1.8 FANTOM5 Ensembl ENCODE 40.2 -97.9 -97860 5.7 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 ZNF548 FOS PPP1R15B MDM4 GYG2P2 ZBED6 SNRPE PIK3C2B RBBP5 PRELP
GH01F203860 1.2 ENCODE 41.6 -654.8 -654824 2.9 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC SNRPE ZBED6 MDM4 PPP1R15B HNRNPA1P59 LOC100506747 PRELP LOC105371691 CYB5R1 LAX1
GH01F204505 1.4 Ensembl ENCODE 35.4 -9.0 -8979 4.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBED6 SNRPE MDM4 GYG2P2 PPP1R15B RBBP5 LRRN2 PIK3C2B TRK-TTT3-2
GH01F205120 1.2 ENCODE 37.6 +605.4 605419 2.9 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D GYG2P2 ELK4 MDM4 TMCC2 PPP1R15B LOC100420878 DSTYK LOC101929459 CNTN2 RPL13AP11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MDM4 on UCSC Golden Path with GeneCards custom track

Promoters for MDM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000551365 421 2001 CREB3L1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263

Genomic Location for MDM4 Gene

Chromosome:
1
Start:
204,516,379 bp from pter
End:
204,581,681 bp from pter
Size:
65,303 bases
Orientation:
Plus strand

Genomic View for MDM4 Gene

Genes around MDM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDM4 Gene

Proteins for MDM4 Gene

  • Protein details for MDM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15151-MDM4_HUMAN
    Recommended name:
    Protein Mdm4
    Protein Accession:
    O15151
    Secondary Accessions:
    • Q2M2Y2
    • Q32SL2
    • Q6GS18
    • Q8IV83

    Protein attributes for MDM4 Gene

    Size:
    490 amino acids
    Molecular mass:
    54864 Da
    Quaternary structure:
    • Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53.

    Three dimensional structures from OCA and Proteopedia for MDM4 Gene

    Alternative splice isoforms for MDM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDM4 Gene

Post-translational modifications for MDM4 Gene

  • Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent.
  • Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MDM4 Gene

Domains & Families for MDM4 Gene

Graphical View of Domain Structure for InterPro Entry

O15151

UniProtKB/Swiss-Prot:

MDM4_HUMAN :
  • Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
  • Belongs to the MDM2/MDM4 family.
  • Contains 1 RanBP2-type zinc finger.
Domain:
  • Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
  • Contains 1 SWIB domain.
Family:
  • Belongs to the MDM2/MDM4 family.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MDM4: view

No data available for Gene Families for MDM4 Gene

Function for MDM4 Gene

Molecular function for MDM4 Gene

GENATLAS Biochemistry:
murine p53 binding protein Mdmx homolog,also homolog to murine Mdm2,ubiquitously expressed with high levels in thymus
UniProtKB/Swiss-Prot Function:
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cisplatin (at protein level).

Gene Ontology (GO) - Molecular Function for MDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10469568
GO:0008270 zinc ion binding IEA,TAS 10608892
GO:0019899 enzyme binding IPI 19838211
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity TAS --
genes like me logo Genes that share ontologies with MDM4: view
genes like me logo Genes that share phenotypes with MDM4: view

Animal Models for MDM4 Gene

MGI Knock Outs for MDM4:

Animal Model Products

miRNA for MDM4 Gene

miRTarBase miRNAs that target MDM4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDM4 Gene

Localization for MDM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDM4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MDM4 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 9226370
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MDM4: view

Pathways & Interactions for MDM4 Gene

genes like me logo Genes that share pathways with MDM4: view

Pathways by source for MDM4 Gene

2 KEGG pathways for MDM4 Gene
1 Qiagen pathway for MDM4 Gene

SIGNOR curated interactions for MDM4 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9226370
GO:0006461 protein complex assembly IDA 10608892
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0008283 cell proliferation IEP 12101245
GO:0008285 negative regulation of cell proliferation TAS 9226370
genes like me logo Genes that share ontologies with MDM4: view

Drugs & Compounds for MDM4 Gene

(5) Drugs for MDM4 Gene - From: PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918
Epirubicin Approved Pharma 383
NSC 207895 (XI-006) Pharma MDMX inhibitor,anti-cancer agent 0
SJ 172550 Pharma MDMX inhibitor 0

(2) ApexBio Compounds for MDM4 Gene

Compound Action Cas Number
NSC 207895 (XI-006) MDMX inhibitor,anti-cancer agent 58131-57-0
SJ 172550 MDMX inhibitor 431979-47-4
genes like me logo Genes that share compounds with MDM4: view

Transcripts for MDM4 Gene

Unigene Clusters for MDM4 Gene

Mdm4 p53 binding protein homolog (mouse):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MDM4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 13d · 13e · 13f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MDM4 Gene

GeneLoc Exon Structure for
MDM4
ECgene alternative splicing isoforms for
MDM4

Expression for MDM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MDM4 Gene

Protein differential expression in normal tissues from HIPED for MDM4 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MDM4 Gene



Protein tissue co-expression partners for MDM4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MDM4 Gene:

MDM4

SOURCE GeneReport for Unigene cluster for MDM4 Gene:

Hs.497492

mRNA Expression by UniProt/SwissProt for MDM4 Gene:

O15151-MDM4_HUMAN
Tissue specificity: Expressed in all tissues tested with high levels in thymus.
genes like me logo Genes that share expression patterns with MDM4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MDM4 Gene

Orthologs for MDM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MDM4 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia MDM4 34 35
  • 92.59 (n)
cow
(Bos Taurus)
Mammalia MDM4 34 35
  • 91.36 (n)
rat
(Rattus norvegicus)
Mammalia Mdm4 34
  • 86.07 (n)
mouse
(Mus musculus)
Mammalia Mdm4 34 16 35
  • 85.52 (n)
oppossum
(Monodelphis domestica)
Mammalia MDM4 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDM4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MDM4 34 35
  • 67.02 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mdm4 34
  • 57.33 (n)
Str.9227 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52974 34
zebrafish
(Danio rerio)
Actinopterygii mdm4 34 35
  • 57.46 (n)
wufa09h09 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for MDM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDM4 Gene

ENSEMBL:
Gene Tree for MDM4 (if available)
TreeFam:
Gene Tree for MDM4 (if available)

Paralogs for MDM4 Gene

Paralogs for MDM4 Gene

Pseudogenes.org Pseudogenes for MDM4 Gene

genes like me logo Genes that share paralogs with MDM4: view

Variants for MDM4 Gene

Sequence variations from dbSNP and Humsavar for MDM4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10458588 -- 204,536,359(+) TCCGT(C/T)TGTCC intron-variant
rs1046874 -- 204,557,932(+) AATAA(C/T)AACAA upstream-variant-2KB, utr-variant-3-prime
rs1052644 -- 204,549,618(+) GAAGG(C/G)TGGGG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs10711972 -- 204,522,864(+) TTGTC(-/T)TTTTT intron-variant
rs10900595 -- 204,542,474(+) TTTAG(A/C)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDM4 Gene

Variant ID Type Subtype PubMed ID
nsv4154 CNV insertion 18451855
nsv826431 CNV loss 20364138

Variation tolerance for MDM4 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MDM4 Gene

Human Gene Mutation Database (HGMD)
MDM4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MDM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDM4 Gene

Disorders for MDM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MDM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intraocular retinoblastoma
  • pediatric intraocular retinoblastoma
familial retinoblastoma
  • retinoblastoma
- elite association - COSMIC cancer census association via MalaCards
Search MDM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MDM4

Genetic Association Database (GAD)
MDM4
Human Genome Epidemiology (HuGE) Navigator
MDM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MDM4
genes like me logo Genes that share disorders with MDM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MDM4 Gene

Publications for MDM4 Gene

  1. Isolation and identification of the human homolog of a new p53- binding protein, Mdmx. (PMID: 9226370) Shvarts A. … Jochemsen A.G. (Genomics 1997) 2 3 4 22 64
  2. MdmX is a substrate for the deubiquitinating enzyme USP2a. (PMID: 19838211) Allende-Vega N. … Saville M.K. (Oncogene 2010) 3 4 22 64
  3. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. (PMID: 16511572) Jin Y. … Lu H. (EMBO J. 2006) 3 4 22 64
  4. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. (PMID: 16163388) Chen L. … Chen J. (EMBO J. 2005) 3 4 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for MDM4 Gene