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Aliases for MDM4 Gene

Aliases for MDM4 Gene

  • MDM4, P53 Regulator 2 3 5
  • Mdm2-Like P53-Binding Protein 3 4
  • Protein Mdmx 3 4
  • MDMX 3 4
  • Mdm4, Transformed 3T3 Cell Double Minute 4, P53 Binding Protein (Mouse) 2
  • Mouse Double Minute 4, Human Homolog Of; P53-Binding Protein 2
  • Double Minute 4, Human Homolog Of; P53-Binding Protein 3
  • Mdm4 P53 Binding Protein Homolog (Mouse) 2
  • Mdm4 P53 Binding Protein Homolog 3
  • P53-Binding Protein Mdm4 4
  • Double Minute 4 Protein 4
  • MDM4 Protein Variant G 3
  • MDM4 Protein Variant Y 3
  • MDM4-Related Protein 1 3
  • MRP1 3
  • HDMX 3

External Ids for MDM4 Gene

Previous GeneCards Identifiers for MDM4 Gene

  • GC01P202211
  • GC01P199946
  • GC01P200846
  • GC01P201662
  • GC01P201629
  • GC01P201217
  • GC01P202752
  • GC01P204486
  • GC01P175650

Summaries for MDM4 Gene

Entrez Gene Summary for MDM4 Gene

  • This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MDM4 Gene

MDM4 (MDM4, P53 Regulator) is a Protein Coding gene. Diseases associated with MDM4 include intraocular retinoblastoma and familial retinoblastoma. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. GO annotations related to this gene include enzyme binding. An important paralog of this gene is MDM2.

UniProtKB/Swiss-Prot for MDM4 Gene

  • Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Gene Wiki entry for MDM4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDM4 Gene

Genomics for MDM4 Gene

Regulatory Elements for MDM4 Gene

Promoters for MDM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MDM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MDM4 Gene

Chromosome:
1
Start:
204,516,379 bp from pter
End:
204,581,681 bp from pter
Size:
65,303 bases
Orientation:
Plus strand

Genomic View for MDM4 Gene

Genes around MDM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDM4 Gene

Proteins for MDM4 Gene

  • Protein details for MDM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15151-MDM4_HUMAN
    Recommended name:
    Protein Mdm4
    Protein Accession:
    O15151
    Secondary Accessions:
    • Q2M2Y2
    • Q32SL2
    • Q6GS18
    • Q8IV83

    Protein attributes for MDM4 Gene

    Size:
    490 amino acids
    Molecular mass:
    54864 Da
    Quaternary structure:
    • Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53.

    Three dimensional structures from OCA and Proteopedia for MDM4 Gene

    Alternative splice isoforms for MDM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDM4 Gene

Proteomics data for MDM4 Gene at MOPED

Post-translational modifications for MDM4 Gene

  • Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent.
  • Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MDM4 Gene

Domains & Families for MDM4 Gene

Graphical View of Domain Structure for InterPro Entry

O15151

UniProtKB/Swiss-Prot:

MDM4_HUMAN :
  • Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
  • Belongs to the MDM2/MDM4 family.
  • Contains 1 RanBP2-type zinc finger.
Domain:
  • Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
  • Contains 1 SWIB domain.
Family:
  • Belongs to the MDM2/MDM4 family.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MDM4: view

No data available for Gene Families for MDM4 Gene

Function for MDM4 Gene

Molecular function for MDM4 Gene

GENATLAS Biochemistry:
murine p53 binding protein Mdmx homolog,also homolog to murine Mdm2,ubiquitously expressed with high levels in thymus
UniProtKB/Swiss-Prot Function:
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cisplatin (at protein level).
genes like me logo Genes that share phenotypes with MDM4: view

Animal Models for MDM4 Gene

MGI Knock Outs for MDM4:

Animal Model Products

miRNA for MDM4 Gene

miRTarBase miRNAs that target MDM4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDM4 Gene

Localization for MDM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MDM4 Gene COMPARTMENTS Subcellular localization image for MDM4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for MDM4 Gene

Pathways & Interactions for MDM4 Gene

genes like me logo Genes that share pathways with MDM4: view

Pathways by source for MDM4 Gene

SIGNOR curated interactions for MDM4 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9226370
GO:0006461 protein complex assembly IDA 10608892
GO:0008283 cell proliferation IEP 12101245
GO:0016567 protein ubiquitination TAS --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with MDM4: view

Drugs & Compounds for MDM4 Gene

(3) Drugs for MDM4 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1844
Epirubicin Approved Pharma 361
genes like me logo Genes that share compounds with MDM4: view

Transcripts for MDM4 Gene

Unigene Clusters for MDM4 Gene

Mdm4 p53 binding protein homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDM4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 13d · 13e · 13f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MDM4 Gene

GeneLoc Exon Structure for
MDM4
ECgene alternative splicing isoforms for
MDM4

Expression for MDM4 Gene

mRNA expression in normal human tissues for MDM4 Gene

Protein differential expression in normal tissues from HIPED for MDM4 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MDM4 Gene



SOURCE GeneReport for Unigene cluster for MDM4 Gene Hs.497492

mRNA Expression by UniProt/SwissProt for MDM4 Gene

O15151-MDM4_HUMAN
Tissue specificity: Expressed in all tissues tested with high levels in thymus.
genes like me logo Genes that share expression patterns with MDM4: view

Protein tissue co-expression partners for MDM4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MDM4 Gene

Orthologs for MDM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MDM4 35
  • 91.36 (n)
  • 90.2 (a)
MDM4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MDM4 35
  • 92.59 (n)
  • 93.88 (a)
MDM4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mdm4 35
  • 85.52 (n)
  • 84.43 (a)
Mdm4 16
Mdm4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MDM4 35
  • 99.52 (n)
  • 99.59 (a)
MDM4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdm4 35
  • 86.07 (n)
  • 84.63 (a)
oppossum
(Monodelphis domestica)
Mammalia MDM4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDM4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MDM4 35
  • 67.02 (n)
  • 62.79 (a)
MDM4 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mdm4 35
  • 57.33 (n)
  • 53.08 (a)
Str.9227 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52974 35
zebrafish
(Danio rerio)
Actinopterygii mdm4 35
  • 57.46 (n)
  • 54.82 (a)
wufa09h09 35
mdm4 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for MDM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDM4 Gene

ENSEMBL:
Gene Tree for MDM4 (if available)
TreeFam:
Gene Tree for MDM4 (if available)

Paralogs for MDM4 Gene

Paralogs for MDM4 Gene

Pseudogenes.org Pseudogenes for MDM4 Gene

genes like me logo Genes that share paralogs with MDM4: view

Variants for MDM4 Gene

Sequence variations from dbSNP and Humsavar for MDM4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4252716 - 204,542,796(+) CTTAA(C/T)TGAAA intron-variant, reference, missense, utr-variant-3-prime
rs4252741 - 204,549,426(+) AGAGA(C/T)CATCT intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs7782 -- 204,557,951(-) GCTGG(A/C)CACAT intron-variant, utr-variant-3-prime
rs882935 -- 204,574,171(+) GACTT(A/C)ATAAT intron-variant
rs885012 -- 204,574,873(-) CTCCA(G/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDM4 Gene

Variant ID Type Subtype PubMed ID
nsv826431 CNV Loss 20364138
nsv4154 CNV Insertion 18451855

Variation tolerance for MDM4 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MDM4 Gene

HapMap Linkage Disequilibrium report
MDM4
Human Gene Mutation Database (HGMD)
MDM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDM4 Gene

Disorders for MDM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MDM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intraocular retinoblastoma
  • pediatric intraocular retinoblastoma
familial retinoblastoma
  • retinoblastoma
- elite association - COSMIC cancer census association via MalaCards
Search MDM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MDM4

Genetic Association Database (GAD)
MDM4
Human Genome Epidemiology (HuGE) Navigator
MDM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MDM4
genes like me logo Genes that share disorders with MDM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MDM4 Gene

Publications for MDM4 Gene

  1. Isolation and identification of the human homolog of a new p53- binding protein, Mdmx. (PMID: 9226370) Shvarts A. … Jochemsen A.G. (Genomics 1997) 2 3 4 23 67
  2. MdmX is a substrate for the deubiquitinating enzyme USP2a. (PMID: 19838211) Allende-Vega N. … Saville M.K. (Oncogene 2010) 3 23
  3. c-Abl phosphorylates Hdmx and regulates its interaction with p53. (PMID: 19075013) Zuckerman V. … Haupt Y. (J. Biol. Chem. 2009) 3 23
  4. Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. (PMID: 19255450) Pazgier M. … Lu W. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  5. High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. (PMID: 19305137) Czarna A. … Holak T.A. (Cell Cycle 2009) 3 23

Products for MDM4 Gene

Sources for MDM4 Gene

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