Aliases for MDM4 Gene
- MDM4, P53 Regulator 2 3
- Mdm2-Like P53-Binding Protein 3 4
- Protein Mdmx 3 4
- MDMX 3 4
- Mdm4, Transformed 3T3 Cell Double Minute 4, P53 Binding Protein (Mouse) 2
- Mouse Double Minute 4, Human Homolog Of; P53-Binding Protein 2
- Double Minute 4, Human Homolog Of; P53-Binding Protein 3
- Mdm4 P53 Binding Protein Homolog (Mouse) 2
- Mdm4 P53 Binding Protein Homolog 3
External Ids for MDM4 Gene
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for MDM4 Gene
MDM4 (MDM4, P53 Regulator) is a Protein Coding gene. Among its related pathways are MicroRNAs in cancer and Glioma. GO annotations related to this gene include enzyme binding. An important paralog of this gene is MDM2.
UniProtKB/Swiss-Prot for MDM4 Gene
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.