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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MDM4 Gene

protein-coding   GIFtS: 61
GCID: GC01P204486

Mdm4 p53 binding protein homolog (mouse)

(Previous names: mouse double minute 4, human homolog of; p53-binding protein,...)
 Explore 32 diseases affiliated with
MDM4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MDM4    

Aliases
for MDM4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mdm4 P53 Binding Protein Homolog (Mouse)1 2     MRP12
MDMX1 2 3     Double Minute 4, Human Homolog Of; P53-Binding Protein2
Mdm2-Like P53-Binding Protein2 3     Mdm4, Transformed 3T3 Cell Double Minute 4, P53 Binding Protein2
Protein Mdmx2 3     MDM4-Related Protein 12
Mdm4, Transformed 3T3 Cell Double Minute 4, P53 Binding Protein (Mouse)1     Protein Mdm42
Mouse Double Minute 4, Human Homolog Of; P53-Binding Protein1     Double Minute 4 Protein3
HDMX2     P53-Binding Protein Mdm43

External Ids:    HGNC: 69741   Entrez Gene: 41942   Ensembl: ENSG000001986257   OMIM: 6027045   UniProtKB: O151513   
ORGUL members:         
NONCODE:n406642    

Export aliases for MDM4 gene to outside databases

Previous GC identifers: GC01P202211 GC01P199946 GC01P200846 GC01P201662 GC01P201629 GC01P201217 GC01P202752 GC01P175650


Summaries
for MDM4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MDM4:
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at
the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor
suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers.
However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain.
This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So
this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and
apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this
gene. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151
Function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional
activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining
suppression of TP53 transactivation and apoptotic functions

Gene Wiki entry for MDM4


Genomic Views
for MDM4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MDM4 gene promoter:
         HEN1   TBP   MZF-1   PPAR-alpha   Elk-1   NRF-2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MDM4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MDM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

MDM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDM4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P204486:  view genomic region     (about GC identifiers)

Start:
 204,485,511 bp from pter      End:
 204,542,871 bp from pter
Size:
 57,361 bases      Orientation:
 plus strand

Proteins
for MDM4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151 (See protein sequence)
Recommended Name: Protein Mdm4  
Size: 490 amino acids; 54864 Da
Subunit: Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with UPB2, MDM2 and MDM4. Interacts
(phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53
Subcellular location: Nucleus
Mass spectrometry: Mass=54863.3; Method=MALDI; Range=1-490; Source=PubMed:11840567;
6/14 PDB 3D structures from and Proteopedia for MDM4 (see all 14):
2CR8 (3D)        2VJE (3D)        2VJF (3D)        2VYR (3D)        3DAB (3D)        3EQY (3D)    
Secondary accessions: Q2M2Y2 Q32SL2 Q6GS18 Q8IV83
Alternative splicing: 5 isoforms:  O15151-1   O15151-2   O15151-3   O15151-4   O15151-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MDM4: NX_O15151

Post-translational modifications:

  • Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and
    • degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent1
  • Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15151

    • MDM4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001191100.1  NP_001191101.1  NP_002384.2  

    ENSEMBL proteins: 
     ENSP00000356150   ENSP00000356148   ENSP00000356147   ENSP00000395254   ENSP00000443816  
     ENSP00000396840   ENSP00000356151   ENSP00000375811  

    Human Recombinant Protein Products: 
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    Novus Biologicals MDM4 Proteins
    Novus Biologicals MDM4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MDM4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9226370


    MDM4 for ontologies           About GeneDecksing



    MDM4 Antibody Products: 
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    ThermoFisher Antibody for MDM4

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    Uscn ELISAs and CLIAs for MDM4

    Protein Domains /
    Families
    for MDM4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MDM4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001841 Znf_RING
     IPR016495 p53_neg-reg_MDM_2/4
     IPR003121 SWIB_MDM2_domain
     IPR013083 Znf_RING/FYVE/PHD
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry O15151

    ProtoNet protein and cluster: O15151

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151
    Domain: Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds
    TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain
    which coordinates two molecules of zinc mediates the heterooligomerization with MDM2
    Similarity: Belongs to the MDM2/MDM4 family
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SWIB domain


    Function
    for MDM4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151
    Function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional
    activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining
    suppression of TP53 transactivation and apoptotic functions
    Induction: Down-regulated by cisplatin (at protein level)

         Genatlas biochemistry entry for MDM4:
    murine p53 binding protein Mdmx homolog,also homolog to murine Mdm2,ubiquitously expressed with high levels in thymus

    miRNA
    Products:            		miRTarBase miRNAs that target MDM4:
    hsa-mir-34a (MIRT004403)

    OriGene 3'-UTR Clone: MDM4
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDM4
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate MDM4 (see all 92):
    hsa-miR-520e hsa-miR-607 hsa-miR-128 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-155* hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmid: MDM4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MDM4 (see all 7)
    OriGene shRNA RFP: MDM4
    OriGene siRNA: MDM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDM4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MDM4

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDM4 

    Cell Line
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    Search LifeMap BioReagents cell lines for MDM4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDM4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding TAS10608892
    GO:0019899enzyme binding IPI19838211


    MDM4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for MDM4: Mdm4tm2.1Glo Mdm4tm1Glo
         15/17 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Mdm4) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hematopoietic system  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  normal  pigmentation 

    MDM4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MDM4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1p53 pathway
    		p53 pathway1.00
    2p53 signaling pathway
    		p53 signaling pathway1.00
    3ATM Pathway
    		ATM Pathway1.00
    4Glioma
    		Signaling Pathways in Glioblastoma0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MDM4
        ATM Pathway

    2 BioSystems Pathways for MDM4 
        Signaling Pathways in Glioblastoma
    p53 pathway


    1         Kegg Pathway  (Kegg details for MDM4):
        p53 signaling pathway


    MDM4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MDM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for MDM4 (O151511, 2, 3 ENSP000003561504) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-3932059,EBI-389668 MINT-4054707 MINT-4054466 MINT-2517946 MINT-4054771 MINT-6801730 MINT-6801769 MINT-6801754 I2D: score=7 STRING: ENSP00000417281
    TP53P046371, 2, 3, ENSP000002693054EBI-3932059,EBI-366083 MINT-7291988 MINT-7292025 MINT-7291962 MINT-2517887 MINT-7291975 MINT-7896820 MINT-7896835 I2D: score=7 STRING: ENSP00000269305
    YWHAGP619812, 3, ENSP000003063304MINT-1957780 MINT-1958362 MINT-1958118 MINT-1958145 MINT-1958602 MINT-1957996 MINT-1958083 I2D: score=4 STRING: ENSP00000306330
    BCL2P104152, 3, ENSP000003296234MINT-7291988 MINT-7292000 MINT-7292013 MINT-7292025 MINT-7291975 I2D: score=1 STRING: ENSP00000329623
    YWHAEP622582, 3, ENSP000002643354MINT-8008314 MINT-8007254 MINT-1958547 I2D: score=3 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9226370
    GO:0006461protein complex assembly IDA10608892
    GO:0006915apoptotic process IEP14660608
    GO:0008283cell proliferation IEP12101245
    GO:0008284positive regulation of cell proliferation IEA--


    MDM4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MDM4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MDM4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MDM4
    1 Novoseek chemical compound relationship for MDM4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cisplatin 4.67 7 19838211 (2), 19578756 (1), 19521340 (1)

    Search CenterWatch for drugs/clinical trials and news about MDM4 

    Transcripts
    for MDM4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MDM4 gene (3 alternative transcripts): 
    NM_001204171.1  NM_001204172.1  NM_002393.4  

    Unigene Cluster for MDM4:

    Mdm4 p53 binding protein homolog (mouse)
    Hs.497492  [show with all ESTs]
    Unigene Representative Sequence: NM_002393
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470797 ENST00000367182(uc010pqw.2 uc010pqx.2 uc001hba.3 uc001hay.2 uc021phx.1 uc001hbb.3 uc009xbe.1 uc001hbc.3 uc001hbd.2)
    ENST00000463049 ENST00000470908 ENST00000471783 ENST00000367180 ENST00000367179
    ENST00000462012 ENST00000444261 ENST00000507825(uc010pqy.2) ENST00000454264
    ENST00000367183 ENST00000391947

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDM4
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate MDM4 (see all 92):
    hsa-miR-520e hsa-miR-607 hsa-miR-128 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-155* hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmid: MDM4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK097188.1 AK223228.1 AK310607.1 AK310903.1 AY923176.1 BC025993.1 BC067299.1 BC105106.1 
    BC143431.1 BC143432.1 NR_024171.2 

    22 DOTS entries:

    DT.95127601  DT.95282299  DT.110582  DT.100022563  DT.70100599  DT.100812369  DT.95241856  DT.100018620 
    DT.100812367  DT.121420232  DT.100653019  DT.75195445  DT.40120176  DT.121420191  DT.442853  DT.100759735 
    DT.100812370  DT.121420184  DT.95270499  DT.95348865  DT.110486  DT.91752055 

    24/235 AceView cDNA sequences (see all 235):

    CA943242 AI275389 AI279044 AA765466 AI272276 AA782648 CA314392 AI168472 
    AI247950 AI127663 BF700112 BC067299 AA657652 CA447894 BP353227 AI147218 
    AA416645 BF115130 BP356616 AL599255 CR613023 BX090301 AA302856 AW196305 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MDM4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ·
    SP1:                          -     -     -                                         -                 -                             -                           
    SP2:                          -     -     -                             -           -                 -                             -                           
    SP3:                                                                    -           -     -     -     -                             -                           
    SP4:                                -     -                                         -                                                                           
    SP5:                                                                                                                          -     -                           

    ExUns: 13d · 13e · 13f
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MDM4

    Expression
    for MDM4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MDM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATTTTCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MDM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MDM4

    SOURCE GeneReport for Unigene cluster: Hs.497492

    UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151
    Tissue specificity: Expressed in all tissues tested with high levels in thymus

        SABiosciences Expression via Pathway-Focused PCR Arrays including MDM4: 
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    Orthologs
    for MDM4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MDM4 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MDM41 Mdm4 p53 binding protein homolog (mouse) 67.87(n)
    64.19(a)    		   419823  XM_417957.3  XP_417957.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 66(a)
    58(a)
    		 1 ↔ many
    1 ↔ many
    		 6(55819466-55819903)
    4(117387198-117406617)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC529742 similar to transformed mouse 3T3 cell double minute more 74.25(n)    BC043773.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa09h092 Danio rerio mRNA similar to Mdm4, transformed 3T3 cell more 73.21(n)    BC047801.1 


    ENSEMBL Gene Tree for MDM4 (if available)
    TreeFam Gene Tree for MDM4 (if available) 

    Paralogs
    for MDM4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MDM4 gene
    MDM22  
    5 SIMAP similar genes for MDM4 using alignment to 5 protein entries:     MDM4_HUMAN (see all proteins):
    DKFZp781B1423    DKFZp686B01123    MDM2 isoform N1_40    HDM2    MDM2

    MDM4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MDM4
    PGOHUM00000241656


    Genomic Variants
    for MDM4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/807 NCBI SNPs in MDM4 are shown (see all 807)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs342429901,2
    		C--175648909(+) TGACCT/-TTTTT 4 -- us2k11Minor allele frequency- -:0.50NA 2
    rs741407141,2
    		C--175648926(+) NNNNTG/TTGAGT 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs2013971941,2
    		C--175649878(+) TTTTTC/TTTTTT 4 -- us2k10--------
    rs715680331,2
    		C--175649879(+) TTTTCT/-TTTTT 4 -- us2k11Minor allele frequency- -:0.50NA 2
    rs42526681,2
    		C,F,H,--175650635(+) TAGGAT/CCTGTG 4 -- ut51 nc-transcript-variantese38Minor allele frequency- C:0.00NS EA NA 774
    rs42526691,2
    		C,--175650874(+) GAAGAG/CTTGTG 4 -- int1 trp31Minor allele frequency- C:0.01NS 180
    rs42457351,2
    		C,F,A,H--175650952(+) CAAACC/TTAAAG 4 -- int16Minor allele frequency- T:0.01NS EA NA 598
    rs42526701,2
    		C,F,H,--175651555(+) ACCTTA/GAAGCT 4 -- int16Minor allele frequency- G:0.02NS EA WA 714
    rs42526711,2
    		C,F--175651990(+) CCTCTT/CGGTGT 4 -- int13Minor allele frequency- C:0.01NS NA 178
    rs42526721,2
    		C,F,--175652031(+) GTCTTC/TTCTCT 4 -- int1 trp37Minor allele frequency- T:0.02NS NA WA 438

    HapMap Linkage Disequilibrium report for MDM4 (204485511 - 204542871 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MDM4: --
    Human Gene Mutation Database (HGMD): MDM4

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    Disorders / Diseases
    for MDM4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MDM4 for disorders           About GeneDecksing

    OMIM gene information: 602704    OMIM disorders: --

    20/32 diseases for MDM4 (see all 32):    About MalaCards
    estrogen-receptor negative breast cancer    testicular germ cell tumor    soft tissue sarcoma    germ cell tumor
    hydranencephaly    oral squamous cell carcinoma    mantle cell lymphoma    squamous cell carcinoma
    papillary thyroid carcinoma    acute myeloid leukemia    myeloid leukemia    malignant glioma
    thyroid carcinoma    rheumatoid arthritis    retinoblastoma    vaccinia
    breast cancer    noma    thyroiditis    sarcoma

    4 Novoseek disease relationships for MDM4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 54.8 8 18045074 (2), 17251377 (1), 20080970 (1), 17080083 (1) (see all 5)
    tumors 46.3 60 18335186 (4), 18172009 (3), 17251377 (3), 18826207 (3) (see all 27)
    cancer 30.8 13 17499002 (2), 18335186 (2), 17128209 (1), 20226197 (1) (see all 8)
    glioblastoma 12.7 3 10626796 (1), 16319692 (1)

    Human Genome Epidemiology (HuGE) Navigator: MDM4 (13 documents)

    Export disorders for MDM4 gene to outside databases

    Publications
    for MDM4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MDM4 gene, integrated from 9 sources (see all 195):
    (articles sorted by number of sources associating them with MDM4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and identification of the human homolog of a new p53- binding protein, Mdmx. (PubMed id 9226370)1, 2, 3, 9 Shvarts A.... Jochemsen A.G. (1997)
    2. MdmX is a substrate for the deubiquitinating enzyme U SP2a. (PubMed id 19838211)1, 2, 9 Allende-Vega N....Saville M.K. (2010)
    3. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. (PubMed id 16163388)1, 2, 9 Chen L....Chen J. (2005)
    4. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. (PubMed id 16511572)1, 2, 9 Jin Y....Lu H. (2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization. (PubMed id 16266988)1, 2 Giglio S....Moretti F. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)
    9. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. (PubMed id 10608892)1, 2 Sharp D.A.... George D.L. (1999)
    10. MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation. (PubMed id 11297540)1, 9 Jackson M.W....Berberich S.J. (2001)

    External Searches for MDM4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MDM4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4194 HGNC: 6974 AceView: MDM4 Ensembl:ENSG00000198625 euGenes: HUgn4194
    ECgene: MDM4 Kegg: 4194 H-InvDB: MDM4

    Other Databases showing MDM4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MDM4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MDM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MDM4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mdm4/

    Intellectual Property
    for MDM4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MDM4 gene:
    Search GeneIP for patents involving MDM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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