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MDM4 Gene

protein-coding   GIFtS: 63
GCID: GC01P204486

MDM4, P53 Regulator

(Previous names: mouse double minute 4, human homolog of; p53-binding protein,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MDM4, P53 Regulator1 2     Double Minute 4, Human Homolog Of; P53-Binding Protein2
Mdm2-Like P53-Binding Protein2 3     Mdm4 P53 Binding Protein Homolog2
Protein Mdmx2 3     MDM4 Protein Variant G2
MDMX2 3     MDM4 Protein Variant Y2
Mdm4 P53 Binding Protein Homolog (Mouse)1     MDM4-Related Protein 12
Mdm4, Transformed 3T3 Cell Double Minute 4, P53 Binding Protein (Mouse)1     Protein Mdm42
Mouse Double Minute 4, Human Homolog Of; P53-Binding Protein1     Double Minute 4 Protein3
HDMX2     P53-Binding Protein Mdm43
MRP12     

External Ids:    HGNC: 69741   Entrez Gene: 41942   Ensembl: ENSG000001986257   OMIM: 6027045   UniProtKB: O151513   

Export aliases for MDM4 gene to outside databases

Previous GC identifers: GC01P202211 GC01P199946 GC01P200846 GC01P201662 GC01P201629 GC01P201217 GC01P202752 GC01P175650


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MDM4 Gene:
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain
at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor
suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human
cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional
activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the
latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression
of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different
isoforms have been noted for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for MDM4 Gene:
MDM4 (MDM4, p53 regulator) is a protein-coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is MDM2.

UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151
Function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional
activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining
suppression of TP53 transactivation and apoptotic functions

Gene Wiki entry for MDM4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MDM4 gene promoter:
         HEN1   TBP   MZF-1   PPAR-alpha   Elk-1   NRF-2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MDM4 promoter sequence
   Search Chromatin IP Primers for MDM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MDM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

MDM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDM4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P204486:  view genomic region     (about GC identifiers)

Start:
204,485,507 bp from pter      End:
204,542,871 bp from pter
Size:
57,365 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151 (See protein sequence)
Recommended Name: Protein Mdm4  
Size: 490 amino acids; 54864 Da
Subunit: Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with UPB2, MDM2 and MDM4. Interacts
(phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53
Mass spectrometry: Mass=54863.3; Method=MALDI; Range=1-490; Source=PubMed:11840567;
Selected PDB 3D structures from and Proteopedia for MDM4 (see all 14):
2CR8 (3D)        2VJE (3D)        2VJF (3D)        2VYR (3D)        3DAB (3D)        3EQY (3D)    
Secondary accessions: Q2M2Y2 Q32SL2 Q6GS18 Q8IV83
Alternative splicing: 5 isoforms:  O15151-1   O15151-2   O15151-3   O15151-4   O15151-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MDM4: NX_O15151

Explore proteomics data for MDM4 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and
    degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent1
  • Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MDM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001191100.1  NP_001191101.1  NP_001265445.1  NP_001265446.1  NP_001265447.1  NP_001265448.1  NP_002384.2  

    ENSEMBL proteins: 
     ENSP00000356150   ENSP00000356148   ENSP00000356147   ENSP00000395254   ENSP00000443816  
     ENSP00000396840   ENSP00000356151   ENSP00000375811  

    MDM4 Human Recombinant Protein Products:

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    Novus Biologicals MDM4 Proteins
    Novus Biologicals MDM4 Lysates
    Sino Biological Recombinant Protein for MDM4
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MDM4

     
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    antibodies-online proteins for MDM4 (9 products) 

     
    antibodies-online peptides for MDM4

    MDM4 Antibody Products:

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    antibodies-online antibodies for MDM4 (89 products) 

    MDM4 Assay Products:

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    Cloud-Clone Corp. ELISAs for MDM4
    Cloud-Clone Corp. CLIAs for MDM4
    Search eBioscience for ELISAs for MDM4 
    antibodies-online kits for MDM4 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001841 Znf_RING
     IPR016495 p53_neg-reg_MDM_2/4
     IPR003121 SWIB_MDM2_domain
     IPR013083 Znf_RING/FYVE/PHD
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry O15151

    ProtoNet protein and cluster: O15151

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151
    Domain: Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also
    binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING
    finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2
    Similarity: Belongs to the MDM2/MDM4 family
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SWIB domain


    Find genes that share domains with MDM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDM4_HUMAN, O15151
    Function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional
    activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining
    suppression of TP53 transactivation and apoptotic functions
    Induction: Down-regulated by cisplatin (at protein level)

         Genatlas biochemistry entry for MDM4:
    murine p53 binding protein Mdmx homolog,also homolog to murine Mdm2,ubiquitously expressed with high levels in
    thymus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10469568
    GO:0008270zinc ion binding TAS10608892
    GO:0019899enzyme binding IPI19838211
         
    Find genes that share ontologies with MDM4           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Mdm4) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hematopoietic system  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  normal  pigmentation 

    Find genes that share phenotypes with MDM4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MDM4: Mdm4tm2.1Glo Mdm4tm1Glo

       genOway: Develop your customized and physiologically relevant rodent model for MDM4

    miRNA
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    miRTarBase miRNAs that target MDM4:
    hsa-mir-192-5p (MIRT026375), hsa-mir-9-5p (MIRT021357), hsa-mir-34a-5p (MIRT004403), hsa-mir-21-5p (MIRT030817), hsa-let-7b-5p (MIRT052186), hsa-mir-215-5p (MIRT024671), hsa-mir-191-5p (MIRT006570)

    Block miRNA regulation of human, mouse, rat MDM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MDM4 (see all 92):
    hsa-miR-520e hsa-miR-607 hsa-miR-128 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-155* hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidMDM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MDM4
    Predesigned siRNA for gene silencing in human, mouse, rat MDM4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): MDM4 (NM_002393)
    Sino Biological Human cDNA Clone for MDM4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDM4

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    eBioscience FlowRNA Probe Sets ( VA1-12259) for MDM4 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MDM4_HUMAN, O15151: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9226370

    Find genes that share ontologies with MDM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MDM4 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41
    2Glioma
    Signaling Pathways in Glioblastoma0.36
    3p53 pathway
    p53 pathway
    4MicroRNAs in cancer
    MicroRNAs in cancer
    5ATM Pathway
    ATM Pathway


    Find genes that share SuperPaths with MDM4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MDM4
        ATM Pathway

    2 BioSystems Pathways for MDM4
        Signaling Pathways in Glioblastoma
    p53 pathway



    2 Kegg Pathways  (Kegg details for MDM4):
        p53 signaling pathway
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MDM4: 
              Cancer Drug Targets in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MDM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MDM4 (O151511, 2, 3 ENSP000003561504) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-398437,EBI-389668 MINT-4054707 MINT-4054466 MINT-2517946 MINT-4054771 MINT-6801730 MINT-6801769 MINT-6801754 I2D: score=7 STRING: ENSP00000417281
    TP53P046371, 2, 3, ENSP000002693054EBI-398437,EBI-366083 MINT-7291988 MINT-7292025 MINT-7291962 MINT-2517887 MINT-7291975 MINT-7896820 MINT-7896835 I2D: score=7 STRING: ENSP00000269305
    YWHAGP619811, 2, 3, ENSP000003063304EBI-398437,EBI-359832 MINT-1957780 MINT-1958362 MINT-1958118 MINT-1958145 MINT-1958602 MINT-1957996 MINT-1958083 I2D: score=4 STRING: ENSP00000306330
    BCL2P104151, 2, 3, ENSP000003296234EBI-398437,EBI-77694 MINT-7291988 MINT-7292000 MINT-7292013 MINT-7292025 MINT-7291975 I2D: score=1 STRING: ENSP00000329623
    YWHAEP622581, 2, 3, ENSP000002643354EBI-398437,EBI-356498 MINT-8008314 MINT-8007254 MINT-1958547 I2D: score=3 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9226370
    GO:0006461protein complex assembly IDA10608892
    GO:0008283cell proliferation IEP12101245
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008285negative regulation of cell proliferation TAS9226370

    Find genes that share ontologies with MDM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MDM4

    1 Novoseek inferred chemical compound relationship for MDM4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cisplatin 4.67 7 19838211 (2), 19578756 (1), 19521340 (1)



    Find genes that share compounds with MDM4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MDM4 gene (7 alternative transcripts): 
    NM_001204171.1  NM_001204172.1  NM_001278516.1  NM_001278517.1  NM_001278518.1  NM_001278519.1  NM_002393.4  

    Unigene Cluster for MDM4:

    Mdm4 p53 binding protein homolog (mouse)
    Hs.497492  [show with all ESTs]
    Unigene Representative Sequence: NM_002393
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470797 ENST00000367182(uc010pqw.2 uc010pqx.2 uc001hba.3 uc001hay.2 uc021phx.1 uc001hbb.3 uc009xbe.1 uc001hbc.3 uc001hbd.2)
    ENST00000463049 ENST00000470908 ENST00000471783 ENST00000367180 ENST00000367179
    ENST00000462012 ENST00000444261 ENST00000507825(uc010pqy.2) ENST00000454264
    ENST00000367183 ENST00000391947
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    hsa-miR-520e hsa-miR-607 hsa-miR-128 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-155* hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidMDM4 3' UTR sequence
    Inhib. RNA
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    eBioscience FlowRNA Probe Sets ( VA1-12259) for MDM4 

    Additional mRNA sequence: 

    AK097188.1 AK223228.1 AK310607.1 AK310903.1 AY923176.1 BC025993.1 BC067299.1 BC105106.1 
    BC143431.1 BC143432.1 NR_024171.2 

    22 DOTS entries:

    DT.95127601  DT.95282299  DT.110582  DT.100022563  DT.70100599  DT.100812369  DT.95241856  DT.100018620 
    DT.100812367  DT.121420232  DT.100653019  DT.75195445  DT.40120176  DT.121420191  DT.442853  DT.100759735 
    DT.100812370  DT.121420184  DT.95270499  DT.95348865  DT.110486  DT.91752055 

    Selected AceView cDNA sequences (see all 235):

    BG619231 CA943242 AA761442 CA314392 AI279044 CR605311 AI247950 BF109762 
    BF700112 BP336630 BM848342 AW196305 AI127663 BM955901 AI275389 AI147218 
    AL599255 AI272276 CR613023 CA447894 BP353227 AA663594 CD515704 AA766075 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MDM4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ·
    SP1:                          -     -     -                                         -                 -                             -                           
    SP2:                          -     -     -                             -           -                 -                             -                           
    SP3:                                                                    -           -     -     -     -                             -                           
    SP4:                                -     -                                         -                                                                           
    SP5:                                                                                                                          -     -                           

    ExUns: 13d · 13e · 13f
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MDM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MDM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTTCCA
    MDM4 Expression
    About this image

    MDM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MDM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497492

    UniProtKB/Swiss-Prot: MDM4_HUMAN, O15151
    Tissue specificity: Expressed in all tissues tested with high levels in thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MDM4: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MDM4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mdm41 , 5 transformed mouse 3T3 cell double minute 41, 5 85.52(n)1
    84.43(a)1
      1 (57.75 cM)5
    172481  NM_008575.31  NP_032601.21 
     1329898455 
    chicken
    (Gallus gallus)
    Aves MDM41 Mdm4 p53 binding protein homolog (mouse) 67.02(n)
    62.79(a)
      419823  XM_004934924.1  XP_004934981.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    68(a)
    57(a)
    1 ↔ many
    1 ↔ many
    6(55819466-55819903)
    4(117383373-117406647)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC529742 similar to transformed mouse 3T3 cell double minute more 74.25(n)    BC043773.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa09h092 Danio rerio mRNA similar to Mdm4, transformed 3T3 cell more 73.21(n)    BC047801.1 


    ENSEMBL Gene Tree for MDM4 (if available)
    TreeFam Gene Tree for MDM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MDM4 gene
    MDM22  
    7 SIMAP similar genes for MDM4 using alignment to 6 protein entries:     MDM4_HUMAN (see all proteins):
    DKFZp781B1423    DKFZp686B01123    MDM2 isoform N1_40    HDM2    MDM2    MDM2 isoform KB9
    mdm2

    Find genes that share paralogs with MDM4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MDM4
    PGOHUM00000241656


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MDM4 (see all 974)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342429901,2
    C--175648909(+) TGACCT/-TTTTT 4 -- us2k11Minor allele frequency- -:0.50NA 2
    rs618179591,2
    C,F--175657638(+) CCCAGA/GAGGCG 4 -- int12Minor allele frequency- G:0.25NA 4
    rs42527011,2
    C,F--175667637(+) CTTCTGAAACAG 
     GGTCT
    /-
    CAGGT
    4 -- cds1 int1 trp31Minor allele frequency- -:0.12NS 178
    rs359180191,2
    C--175686221(+) GAGCT-/AAAAAA 4 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.25NA 4
    rs560842421,2
    C--204486982(+) TTTTTT/-AATAG 4 -- int11Minor allele frequency- -:0.00NA 2
    rs107119721,2
    C--204491992(+) TTGTC-/TTTTTT 4 -- int1 trp30--------
    rs727520991,2
    C,F--204492287(+) TGCCCG/AGCTGA 4 -- int12Minor allele frequency- A:0.13NA 122
    rs2003881191,2
    C--204495595(+) TTTTT-/TGAGAT 4 -- int10--------
    rs725010251,2
    C--204496829(+) AAACW-/TTYWTGC 4 -- int10--------
    rs114404001,2
    C--204497202(+) TTTTTT/-AGTTT 4 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for MDM4 (204485507 - 204542871 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MDM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4154CNV Insertion18451855
    nsv826431CNV Loss20364138

    Human Gene Mutation Database (HGMD): MDM4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MDM4
    DNA2.0 Custom Variant and Variant Library Synthesis for MDM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602704    OMIM disorders: --


    Find genes that share disorders with MDM4           About GenesLikeMe

    4 Novoseek inferred disease relationships for MDM4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 54.8 8 18045074 (2), 17251377 (1), 20080970 (1), 17080083 (1) (see all 5)
    tumors 46.3 60 18335186 (4), 18172009 (3), 17251377 (3), 18826207 (3) (see all 27)
    cancer 30.8 13 17499002 (2), 18335186 (2), 17128209 (1), 20226197 (1) (see all 8)
    glioblastoma 12.7 3 10626796 (1), 16319692 (1)

    Genetic Association Database (GAD): MDM4
    Human Genome Epidemiology (HuGE) Navigator: MDM4 (13 documents)

    Export disorders for MDM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MDM4 gene, integrated from 10 sources (see all 216):
    (articles sorted by number of sources associating them with MDM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and identification of the human homolog of a new p53- binding protein, Mdmx. (PubMed id 9226370)1, 2, 3, 9 Shvarts A.... Jochemsen A.G. (Genomics 1997)
    2. MdmX is a substrate for the deubiquitinating enzyme USP2a. (PubMed id 19838211)1, 2, 9 Allende-Vega N.... Saville M.K. (Oncogene 2010)
    3. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. (PubMed id 16163388)1, 2, 9 Chen L.... Chen J. (EMBO J. 2005)
    4. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. (PubMed id 16511572)1, 2, 9 Jin Y.... Lu H. (EMBO J. 2006)
    5. Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population. (PubMed id 20855462)1, 4 Sun T....Kantoff P.W. (Clin. Cancer Res. 2010)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    7. Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations. (PubMed id 20520810)1, 4 Fang S....Amos C.I. (PLoS ONE 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity. (PubMed id 21084273)1, 4 Wynendaele J....Bartel F. (Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4194 HGNC: 6974 AceView: MDM4 Ensembl:ENSG00000198625 euGenes: HUgn4194
    ECgene: MDM4 Kegg: 4194 H-InvDB: MDM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MDM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MDM4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mdm4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MDM4 gene:
    Search GeneIP for patents involving MDM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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