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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MDM2 Gene

protein-coding   GIFtS: 74
GCID: GC12P069201

Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)

(Previous names: mouse double minute 2, human homolog of; p53-binding protein,...)
 Explore 217 diseases affiliated with
MDM2 via
MalaCards
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 Human Malady Compendium 
Biological research products
for MDM2    

Aliases
for MDM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mdm2, P53 E3 Ubiquitin Protein Ligase Homolog (Mouse)1 2     HDM2 Transcript Variant MYO-202
HDMX1 2     HDM2 Transcript Variant MYO-242
Oncoprotein Mdm22 3     HDM2 Transcript Variant MYO-252
HDM21     HDM2 Transcript Variant MYO-262
MGC53701     HDM2 Transcript Variant MYO-322
Mdm2 P53 Binding Protein Homolog (Mouse)1     HDM2 Transcript Variant MYO-42
Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse)1     MDM2 Variant FB282
Mouse Double Minute 2, Human Homolog Of; P53-Binding Protein1     MDM2 Variant FB302
ACTFS2     Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein2
Double Minute 2, Human Homolog Of; P53-Binding Protein2     EC 6.3.2.-3
E3 Ubiquitin-Protein Ligase Mdm22     Hdm23
Hdm23     Double Minute 2 Protein3
HDM2 Transcript Variant MYO-12     P53-Binding Protein Mdm23
HDM2 Transcript Variant MYO-182     EC 6.3.28

External Ids:    HGNC: 69731   Entrez Gene: 41932   Ensembl: ENSG000001356797   OMIM: 1647855   UniProtKB: Q009873   

Export aliases for MDM2 gene to outside databases

Previous GC identifers: GC12M068977 GC12P069030 GC12P068918 GC12P067488 GC12P066253


Summaries
for MDM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MDM2:
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear
phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative
feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its
tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for
proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions
with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced
transcript variants have been isolated from both tumor and normal tissues. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MDM2_HUMAN, Q00987
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the
proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional
activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of
p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits
DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53
complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth
factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in
nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation

summary for MDM2:
Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or
a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases.
Ubiquitin ligases, such as MDM2, E3A and anaphase-promoting complex, attach ubiquitin molecules onto lysine
residues of target proteins. Ubiquitin ligases function as a complex of an E1-activating enzyme, an
E2-conjugating enzyme and an E3-ubiquiting enzyme. Using ATP, E1 activates the ubiquitin molecule and
transfer it to E2. E2 interacts with E3 partners to transfer the ubiquitin moeity to the target protein.
Generally multiple ubiquitin molecules are attached (polyubiquitination), which marks the target protein for
proteasomal degradation.

Gene Wiki entry for MDM2 (Mdm2)


Genomic Views
for MDM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MDM2 gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MDM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MDM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3-q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q13-q14

MDM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDM2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069201:  view genomic region     (about GC identifiers)

Start:
 69,201,956 bp from pter      End:
 69,239,214 bp from pter
Size:
 37,259 bases      Orientation:
 plus strand

Proteins
for MDM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MDM2_HUMAN, Q00987 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase Mdm2  
Size: 491 amino acids; 55233 Da
Subunit: Binds p53/TP53, TP73/p73, ARF/P14, PML, RBL5 and RP11, and specifically to RNA. Can interact with RB1,
E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX.
Interacts with CDKN2AIP, MTBP, RFWD3, TBRG1, USP7, PYHIN1, UBXN6, and RBBP6. Isoform Mdm2-F does not interact with
p53/TP53. Interacts with and ubiquitinates HIV-1 Tat. Interacts with ARRB1 and ARRB2. Interacts (isoform 2) with
PSMA3. Found in a trimeric complex with MDM2, MDM4 and UPB2. Interacts with USP2 (via N-terminus and C-terminus).
Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7.
Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the
interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts
with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also component of the
TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both
p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses
with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex. Interacts with DYRK2. Interacts with
IGF1R. Interacts with TRIM13; the interaction ubiquitinates MDM2 leading to its proteasomal degradation. Interacts
with SNAI1; this interaction promotes SNAI1 ubiquitination. Interacts with NOTCH1 (via intracellular domain).
Interacts with FHIT
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the
nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar
localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both
proteins. Colocalizes with RASSF1 isoform A in the nucleus
Miscellaneous: MDM2 RING finger mutations that failed to ubiquitinate p53 in vitro did not target p53 for degradation
when expressed in cells
6/36 PDB 3D structures from and Proteopedia for MDM2 (see all 36):
1RV1 (3D)        1T4E (3D)        1T4F (3D)        1YCR (3D)        1Z1M (3D)        2AXI (3D)    
Secondary accessions: A6NL51 A8K2S6 Q13226 Q13297 Q13298 Q13299 Q13300 Q13301 Q53XW0 Q71TW9 Q8WYJ1
Q8WYJ2 Q9UGI3 Q9UMT8
Alternative splicing: 11 isoforms:  Q00987-1   Q00987-2   Q00987-3   Q00987-4   Q00987-5   Q00987-6   Q00987-7   Q00987-8   
Q00987-9   Q00987-10   Q00987-11   

Explore the universe of human proteins at neXtProt for MDM2: NX_Q00987

Post-translational modifications:

  • Phosphorylated in response to ionizing radiation in an ATM-dependent manner. Phosphorylation on Ser-166 by SGK1
    • activates ubiquitination of p53/TP531
  • Auto-ubiquitinated; which leads to proteasomal degradation. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads
    • to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its
    stabilization1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q00987

    • 4/13 DME Specific Peptides for MDM2 (Q00987) (see all 13)
     MIYRNLV  DTYTMKE  DDKITQAS  GESDTDSFE 

    MDM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002383.2  
    ENSEMBL proteins: 
     ENSP00000417281   ENSP00000310742   ENSP00000429021   ENSP00000258148   ENSP00000444430  
     ENSP00000377067   ENSP00000427828   ENSP00000439238   ENSP00000377068   ENSP00000441841  
     ENSP00000377062   ENSP00000429692   ENSP00000299252   ENSP00000431110   ENSP00000353611  
     ENSP00000430257   ENSP00000444597   ENSP00000445222   ENSP00000445030   ENSP00000444566  
     ENSP00000443450   ENSP00000444028   ENSP00000377065   ENSP00000266624   ENSP00000335096  
     ENSP00000430906   ENSP00000258149   ENSP00000348637   ENSP00000440932   ENSP00000410694  
     ENSP00000377064  
    Reactome Protein details: Q00987
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MDM2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MDM2
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    Novus Biologicals MDM2 Proteins
    Novus Biologicals MDM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MDM2

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA10707090
    GO:0005737cytoplasm IMP--
    GO:0005829cytosol TAS--


    MDM2 for ontologies           About GeneDecksing



    MDM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MDM2
    R&D Systems Antibodies for MDM2 (MDM2/HDM2)
    Cell Signaling Technology (CST) Antibodies for MDM2 
    OriGene Antibodies (see all 5): MDM2
    OriGene Custom Antibody Services for MDM2 
    GenScript Custom Superior Antibodies Services for MDM2
    Novus Biologicals MDM2 Antibodies
    Abcam antibodies for MDM2 
    Uscn Antibodies for MDM2
    ThermoFisher Antibody for MDM2

    Assay Products for MDM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MDM2 (MDM2/HDM2)         (see all)
    GenScript Custom Assay Services for MDM2
    Enzo Life Sciences assays for MDM2
    Uscn ELISAs and CLIAs for MDM2

    Protein Domains /
    Families
    for MDM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MDM2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001841 Znf_RING
     IPR016495 p53_neg-reg_MDM_2/4
     IPR003121 SWIB_MDM2_domain
     IPR013083 Znf_RING/FYVE/PHD
     IPR015459 MDM2_E3_ligase

    Graphical View of Domain Structure for InterPro Entry Q00987

    ProtoNet protein and cluster: Q00987

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: MDM2_HUMAN, Q00987
    Domain: Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73
    and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a
    putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically
    with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its
    ubiquitin ligase E3 activity toward p53 and itself
    Similarity: Belongs to the MDM2/MDM4 family
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SWIB domain


    Function
    for MDM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MDM2_HUMAN, Q00987
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the
    proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional
    activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of
    p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits
    DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53
    complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth
    factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in
    nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation
    Induction: By DNA damage

         Genatlas biochemistry entry for MDM2:
    p53 associated protein 9,(homolog to murine oncogene Mdm2,present on a mouse double minute chromosome),downregulating
    TP53,acting as an E3 ubiquitin ligase directly transferring ubiquitin and targetting TP53 to proteasome complex for
    degradation,expressed in different layers of normal skin,amplified in human sarcoma,malignant
    glioma,angiosarcoma,liposarcoma and anaplastic astrocytoma,and diffuse large B cell lymphoma

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MDM2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDM2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MDM2:
    hsa-miR-548a-3p hsa-miR-494 hsa-miR-513a-3p hsa-miR-548e hsa-miR-551b* hsa-miR-548c-3p hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MDM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MDM2 (see all 7)
    OriGene shRNA RFP: MDM2
    OriGene siRNA: MDM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDM2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MDM2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MDM2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MDM2 (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MDM2 (NM_002392)
    Sino Biological Human cDNA Clone for MDM2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDM2 

    Cell Line
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    Search LifeMap BioReagents cell lines for MDM2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDM2

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI9529249
    GO:0004842ubiquitin-protein ligase activity IMP19372219
    GO:0005515protein binding IPI19372219
    GO:0008270zinc ion binding IDA10722742
    GO:0019899enzyme binding IPI18566590


    MDM2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MDM2:
     Decreased influenza A/WSN/33 r  Increased cell death HMECs cel  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for MDM2: Mdm2tm1Glo Mdm2tm2.2Glo Mdm2tm2.3Glo Mdm2tm1Bay Mdm2tm1.1Mep
         15/21 MGI mutant phenotypes (inferred from 17 alleles) (MGI details for Mdm2) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hematopoietic system  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    MDM2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MDM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/60 super-pathways (see all 60) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    3Ubiquitinated Orc1 is degraded by the proteasome
    		Stabilization of p530.91
    		G1/S DNA Damage Checkpoints0.79
    		p53-Dependent G1/S DNA damage checkpoint0.83
    		Cell Cycle Checkpoints0.42
    		p53-Dependent G1 DNA Damage Response0.83
    4Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		p53 Signaling0.32
    		G2-M Phase Transition0.59
    		DNA Repair Mechanisms0.32
    5Glioma
    		Glioma1.00
    		Prostate cancer0.39
    		Melanoma0.43
    		Signaling Pathways in Glioblastoma0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 EMD Millipore Pathways for MDM2 (see all 9)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Development Angiotensin signaling via beta-Arrestin
    Signal transduction PTEN pathway
    Proteolysis Putative SUMO-1 pathway
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MDM2 (see all 15)
        Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    HIF1Alpha Pathway
    PTEN Pathway
    Glioblastoma Multiforme

    3 Cell Signaling Technology (CST) Pathways for MDM2
        Cell Cycle / Checkpoint Control
    PI3K / Akt Signaling
    DNA Damage

    1 Tocris Bioscience Pathway for MDM2
        Akt Pathway

    5/8 GeneGo (Thomson Reuters) Pathways for MDM2 (see all 8)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Proteolysis Putative SUMO-1 pathway
    Transcription P53 signaling pathway
    Development Angiotensin signaling via beta-Arrestin
    Signal transduction AKT signaling

    5/23 BioSystems Pathways for MDM2 (see all 23) 
        TP53 network
    DNA damage response (only ATM dependent)
    Signaling Pathways in Glioblastoma
    ErbB signaling pathway
    Integrated Breast Cancer Pathway

    5/41        Reactome Pathways for MDM2 (see all 41)
        Signaling by EGFR in Cancer
    G1/S DNA Damage Checkpoints
    Downstream signal transduction
    Signal Transduction
    p53-Dependent G1/S DNA damage checkpoint


    5/10         Kegg Pathways  (Kegg details for MDM2) (see all 10):
        Cell cycle
    p53 signaling pathway
    Ubiquitin mediated proteolysis
    Endocytosis
    Pathways in cancer


    MDM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MDM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/491 Interacting proteins for MDM2 (Q009871, 2, 3 ENSP000004172814) via UniProtKB, MINT, STRING, and/or I2D (see all 491)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-389668,EBI-366083 MINT-6540920 MINT-4793511 MINT-6823775 MINT-7013943 MINT-8303857 MINT-6540905 MINT-68742 MINT-8385459 MINT-56681 MINT-8374464 MINT-58468 MINT-7013791 MINT-68743 MINT-7013956 MINT-4545014 MINT-8339574 MINT-4049631 MINT-6540776 MINT-6801380 MINT-8374452 MINT-58465 MINT-7013688 MINT-7013802 MINT-4303990 MINT-8339590 MINT-6665330 MINT-4793467 MINT-8380636 MINT-4049616 MINT-4054304 MINT-7905142 MINT-8385480 MINT-7013780 MINT-6540889 MINT-8385531 MINT-8385552 MINT-8385886 MINT-8388795 MINT-8415355 MINT-6540807 MINT-8391984 MINT-7905326 MINT-6540796 I2D: score=12 STRING: ENSP00000269305
    MDM4O151511, 2, 3, ENSP000003561504EBI-389668,EBI-3932059 MINT-6801769 MINT-2517946 MINT-4054707 MINT-4054771 MINT-6801754 MINT-4054466 MINT-6801730 I2D: score=7 STRING: ENSP00000356150
    RYBPQ8N4882, 3, ENSP000004194944MINT-7013847 MINT-7013730 MINT-7013672 MINT-7013688 MINT-7013864 MINT-7013883 MINT-7013780 MINT-7013760 MINT-7013717 MINT-7013897 MINT-7013745 I2D: score=2 STRING: ENSP00000419494
    PSME3P612892, 3, ENSP000002933624MINT-6540807 MINT-6540920 MINT-6540776 MINT-6540837 MINT-6540985 MINT-6540796 MINT-6540853 MINT-6540998 MINT-6540973 I2D: score=3 STRING: ENSP00000293362
    NCLP193381, 2, 3, ENSP000003181954EBI-389668,EBI-352553 MINT-8291977 MINT-8291996 MINT-8291950 MINT-8292184 MINT-8292547 MINT-8292023 I2D: score=3 STRING: ENSP00000318195
    About this table

    Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9271120
    GO:0006461protein complex assembly IDA12915590
    GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS--
    GO:0007089traversing start control point of mitotic cell cycle IEA--


    MDM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MDM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MDM2 for compounds           About GeneDecksing

    EMD Millipore small molecules for MDM2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MDM2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 66811MDM2 inhibitor. Disrupts MDM2-p53 interaction[6964-62-1]
    Nutlin-3MDM2 antagonist; inhibits MDM2-p53 interaction[548472-68-0]
    RITAp53-MDM2 interaction inhibitor; antitumor[213261-59-7]

    4 HMDB Compounds for MDM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 DrugBank Compounds for MDM2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone-- --target--17139284 17016423 10592235
    Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone-- --target--17139284 17016423

    10/102 Novoseek chemical compound relationships for MDM2 gene (see all 102)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 55.7 7 18340116 (1), 14749479 (1), 19934289 (1), 17043642 (1) (see all 7)
    leptomycin b 53.6 13 10222137 (3), 9819415 (2), 12653667 (1), 17178878 (1) (see all 6)
    10-hydroxycamptothecin 47.4 3 12149568 (1), 10493945 (1), 13130078 (1)
    mg 132 46.3 10 9438391 (2), 12640129 (1), 16571800 (1), 11526482 (1) (see all 7)
    camptothecin 44.1 11 19261878 (1), 19136059 (1), 10399957 (1), 17056014 (1) (see all 6)
    cisplatin 39.1 61 16815295 (6), 7761100 (4), 11761456 (4), 9700726 (3) (see all 23)
    p202 38.9 2 8910340 (1)
    adriamycin 38.4 20 10637478 (3), 12640129 (2), 10775510 (2), 15064747 (2) (see all 11)
    doxorubicin 35.4 28 9548451 (4), 10544021 (2), 11964305 (2), 14766674 (2) (see all 15)
    oligonucleotide 33.8 44 18038763 (4), 11894120 (2), 12149568 (2), 11072252 (2) (see all 20)

    Search CenterWatch for drugs/clinical trials and news about MDM2 

    Transcripts
    for MDM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MDM2 gene (11 alternative transcripts): 
    NM_002392.4  NM_001145336.1  NM_001145337.1  NM_001145339.1  NM_001145340.1  NM_006878.3  NM_006879.3  NM_006880.2  
    NM_006881.3  NM_006882.3  NM_032739.1  

    Unigene Clusters for MDM2:

    Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
    Hs.484551  [show with all ESTs], Hs.733536  [show with all ESTs]
    Unigene Representative Sequences: NM_002392, JX015388
    18/38 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 38):
    ENST00000462284(uc001sui.3 uc021rad.1 uc009zqx.3 uc001sun.4 uc009zra.3 uc021raf.1 uc009zrc.3 uc009zrd.3 uc009zre.3 uc001suo.3 uc009zrf.3 uc009zrg.3 uc009zrh.3 uc021rag.1 uc021rah.1 uc021rai.1 uc021raj.1)
    ENST00000311420 ENST00000493419 ENST00000393417(uc009zrb.1) ENST00000258148
    ENST00000539479(uc009zqy.1) ENST00000393415(uc021rae.1) ENST00000523991
    ENST00000543323 ENST00000393416 ENST00000544561 ENST00000393410 ENST00000496959
    ENST00000299252 ENST00000481186 ENST00000360430 ENST00000517852 ENST00000545204


    miRNA
    Products:             		 OriGene 3'-UTR Clone: MDM2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDM2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MDM2:
    hsa-miR-548a-3p hsa-miR-494 hsa-miR-513a-3p hsa-miR-548e hsa-miR-551b* hsa-miR-548c-3p hsa-miR-556-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MDM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MDM2 (see all 7)
    OriGene shRNA RFP: MDM2
    OriGene siRNA: MDM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDM2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MDM2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MDM2 (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MDM2 (NM_002392)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDM2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MDM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MDM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDM2

    Additional cDNA sequence: 

    AF385326.1 AJ278976.1 AJ278977.1 AJ278978.1 AJ550516.1 AJ550518.1 AJ550520.1 JX015381.1 
    JX015382.1 JX015383.1 JX015384.1 JX015385.1 JX015387.1 JX015388.1 

    24/27 DOTS entries (see all 27):

    DT.92448784  DT.100787335  DT.95193404  DT.91749816  DT.95193408  DT.100686963  DT.121211579  DT.204679 
    DT.121211593  DT.100787329  DT.40118121  DT.451569  DT.121167413  DT.92448783  DT.100027326  DT.100651391 
    DT.100787331  DT.40118120  DT.75138122  DT.91749814  DT.95193415  DT.95193421  DT.95306934  DT.95312544 

    24/214 AceView cDNA sequences (see all 214):

    BM557395 AA825908 AI478408 BG532258 AI373062 BM980488 AI824182 BE018851 
    CB269619 AI804945 U33199 NM_006880 BQ001500 BQ014357 BU150642 AF385325 
    AJ491698 BX491664 BM463523 AA470116 AJ550518 AF385323 AF201371 U33200 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MDM2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                                      -     -           -                                                         
    SP2:                                      -     -     -     -                                                         
    SP3:                                      -     -           -           -     -                                       
    SP4:                                      -     -           -                                                         
    SP5:                                      -     -     -     -                                                         


    ECgene alternative splicing isoforms for MDM2

    Expression
    for MDM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MDM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCAAAGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MDM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteLumbar Vertebral BodySomite
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MDM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MDM2

    SOURCE GeneReport for Unigene clusters: Hs.484551 Hs.733536

    UniProtKB/Swiss-Prot: MDM2_HUMAN, Q00987
    Tissue specificity: Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform
    Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including MDM2 (see all 11): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Tumor Metastasis in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MDM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MDM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDM2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDM2

    Orthologs
    for MDM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MDM2 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mdm21 , 5 transformed mouse 3T3 cell double minute 21, 5 82.71(n)1
    83.2(a)1    		   10 (66.32 cM)5
    172461  NM_010786.31  NP_034916.11 
     1176888885 
    chicken
    (Gallus gallus)    		 Aves MDM21 Mdm2 p53 binding protein homolog (mouse) 72.3(n)
    69.31(a)    		   395609  NM_001199384.1  NP_001186313.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MDM26
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343256.1(1440982-1454929)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.108852 Xenopus laevis transcribed sequence with weak similarity more 73.75(n)    BQ385125.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mdm22 murine double minute 2 homolog 71.63(n)   30637  AF356346.1 


    ENSEMBL Gene Tree for MDM2 (if available)
    TreeFam Gene Tree for MDM2 (if available) 

    Paralogs
    for MDM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MDM2 gene
    MDM42  
    10 SIMAP similar genes for MDM2 using alignment to 31 protein entries:     MDM2_HUMAN (see all proteins):
    HDM2    mdm2    L3MBTL2    MDM2 isoform N1_40    DKFZp781B1423    MDM2 isoform KB9
    MDM4    DKFZp686B01123    ETFA    NEURL1B

    MDM2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MDM2
    PGOHUM00000259775 PGOHUM00000240593


    Genomic Variants
    for MDM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: MDM2_HUMAN, Q00987
    Polymorphism: A polymorphism in the MDM2 promoter is associated with susceptibility to accelerated tumor formation in
    both hereditary and sporadic cancers [MIM:614401]. It also contributes to susceptibility to Li-Fraumeni syndrome, in
    patients carrying a TP53 germline mutation


    10/764 NCBI SNPs in MDM2 are shown (see all 764)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1153999191,2
    		F,--69200189(+) GCACAA/TACCCA 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1475658861,2
    		--69200210(+) TGATAG/TTTAAC 1 -- us2k10--------
    rs1887975101,2
    		--69200332(+) TCTGCC/TTCCCG 1 -- us2k10--------
    rs1403302471,2
    		--69200358(+) TCTGCC/TTCAGC 1 -- us2k10--------
    rs1815507851,2
    		--69200474(+) CCTAAC/TCTCGT 1 -- us2k10--------
    rs11449441,2
    		C,F,A,--69200485(+) GATCCG/ACCCAC 1 -- us2k17Minor allele frequency- A:0.38NA WA CSA 13
    rs1456726811,2
    		--69200535(+) CCGTGC/TGCAGC 1 -- us2k10--------
    rs794050011,2
    		C,F,--69200648(+) GATGAA/GGATGA 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1505500231,2
    		C,--69200776(+) GCGGG-/AGAAGGGAAGGATATAACT
    TTATAAAAAAAAAAAAGCTGC    AGAAG     		1 -- us2k10--------
    rs37304861,2
    		C,F,--69201242(+) acgccC/Tgacta 1 -- us2k11Minor allele frequency- T:0.01NS 172

    HapMap Linkage Disequilibrium report for MDM2 (69201956 - 69239214 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MDM2: --
    Human Gene Mutation Database (HGMD): MDM2

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing MDM2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MDM2
    DNA2.0 Custom Variant and Variant Library Synthesis for MDM2

    Disorders / Diseases
    for MDM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MDM2 for disorders           About GeneDecksing

    OMIM gene information: 164785    OMIM disorders: --

    UniProtKB/Swiss-Prot: MDM2_HUMAN, Q00987
  • Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A
    • higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade
    ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding

    20/217 diseases for MDM2 (see all 217):    About MalaCards
    li-fraumeni syndrome    accelerated tumor formation    malignant peripheral nerve sheath tumor    malignant fibrous histiocytoma
    adult astrocytic tumour    fibrous histiocytoma    non-hodgkin lymphoma    b-cell non-hodgkin lymphoma
    retinoblastoma    congenital mesoblastic nephroma    diffuse large b-cell lymphoma    human t-cell leukemia virus type 1
    primitive neuroectodermal tumor    soft tissue sarcoma    non-hodgkin lymphoma, childhood    gliomatosis cerebri
    mesoblastic nephroma    atypical lipomatous tumor    peripheral primitive neuroectodermal tumor    west nile virus

    4 diseases from the University of Copenhagen DISEASES database for MDM2:
    Cancer     Lipoma     Li-Fraumeni syndrome     Eye disease

    10/96 Novoseek disease relationships for MDM2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liposarcoma dedifferentiated 84.6 30 15221942 (4), 18500263 (3), 9071997 (2), 18214854 (2) (see all 20)
    tumors 80.8 1210 9671804 (7), 10815906 (5), 10072445 (5), 10918230 (5) (see all 99)
    liposarcoma 78.5 80 18836421 (7), 14694526 (4), 18820664 (3), 19820690 (3) (see all 37)
    retinoblastoma 71.4 60 18644346 (5), 19524506 (3), 18045074 (3), 16966622 (2) (see all 37)
    cancer 70.8 340 16243710 (5), 12149568 (4), 15720187 (4), 17931661 (4) (see all 99)
    sarcoma 70.6 144 18521197 (4), 16160477 (4), 8064888 (4), 14614050 (3) (see all 84)
    glioblastoma 63.4 60 9034372 (6), 9810172 (3), 11212898 (3), 12635658 (3) (see all 30)
    osteosarcoma 62.8 79 8416741 (5), 8781571 (4), 10374529 (3), 15310147 (3) (see all 40)
    li-fraumeni syndrome 61.3 5 16478747 (1), 7923211 (1), 16983111 (1), 16203772 (1) (see all 5)
    anaplastic astrocytoma 56.9 7 12700122 (2), 12241107 (1), 7815080 (1), 9266437 (1) (see all 6)

    Genetic Association Database (GAD): MDM2
    Human Genome Epidemiology (HuGE) Navigator: MDM2 (192 documents)
    Tumor Gene Database (TGDB): MDM2

    Export disorders for MDM2 gene to outside databases

    Publications
    for MDM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MDM2 gene, integrated from 9 sources (see all 2169):
    (articles sorted by number of sources associating them with MDM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Amplification of a gene encoding a p53-associated protein in human sarcomas. (PubMed id 1614537)1, 2, 3 Oliner J.D.... Vogelstein B. (1992)
    2. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. (PubMed id 17290220)1, 2, 9 Stevenson L.F....Saville M.K. (2007)
    3. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. (PubMed id 8875929)1, 2, 9 Kussie P.H.... Pavletich N.P. (1996)
    4. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. (PubMed id 16337594)1, 2, 9 Sdek P.... Xiao Z.X. (2005)
    5. Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. (PubMed id 16287156)1, 4, 9 Zhang X....Lin D. (2006)
    6. Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. (PubMed id 16152608)1, 4, 9 Hu Z....Shen H. (2006)
    7. Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population. (PubMed id 16288830)1, 4, 9 Ma H....Shen H. (2006)
    8. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. (PubMed id 10723139)1, 2, 9 Honda R. and Yasuda H. (2000)
    9. Molecular recognition of p53 and MDM2 by USP7/HAUSP. (PubMed id 16474402)1, 2, 9 Sheng Y....Frappier L. (2006)
    10. Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. (PubMed id 16402859)1, 2, 9 Hu M.... Shi Y. (2006)

    External Searches for MDM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing MDM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4193 HGNC: 6973 AceView: MDM2 Ensembl:ENSG00000135679 euGenes: HUgn4193
    ECgene: MDM2 Kegg: 4193 H-InvDB: MDM2

    Other Databases showing MDM2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MDM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MDM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MDM2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mdm2/
    Wikipedia http://en.wikipedia.org/wiki/Mdm2

    Intellectual Property
    for MDM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MDM2 gene:
    Search GeneIP for patents involving MDM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of MDM2
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     MDM2 Proteins, Antibodies, CLIAs, and ELISAs
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