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Aliases for MDM1 Gene

Aliases for MDM1 Gene

  • Mdm1 Nuclear Protein Homolog (Mouse) 2 3
  • Mdm4, Transformed 3T3 Cell Double Minute 1, P53 Binding Protein (Mouse) 2

External Ids for MDM1 Gene

Previous GeneCards Identifiers for MDM1 Gene

  • GC12M068204
  • GC08U900012
  • GC12M066975
  • GC12M068688
  • GC12M065739

Summaries for MDM1 Gene

Entrez Gene Summary for MDM1 Gene

  • This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles, is amplified in the mouse transformed 3T3 cell line, and the encoded protein is able to bind to p53. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for MDM1 Gene

MDM1 (Mdm1 Nuclear Protein Homolog (Mouse)) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDM1 Gene

Genomics for MDM1 Gene

Regulatory Elements for MDM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MDM1 Gene

68,272,443 bp from pter
68,332,381 bp from pter
59,939 bases
Minus strand

Genomic View for MDM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MDM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDM1 Gene

Proteins for MDM1 Gene

  • Protein details for MDM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear protein MDM1
    Protein Accession:
    Secondary Accessions:
    • B4DM65
    • E7EPQ3
    • O43406
    • Q8WTV9
    • Q9NR04

    Protein attributes for MDM1 Gene

    714 amino acids
    Molecular mass:
    80735 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MDM1 Gene


neXtProt entry for MDM1 Gene

Proteomics data for MDM1 Gene at MOPED

Post-translational modifications for MDM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MDM1 Gene

Domains for MDM1 Gene

Protein Domains for MDM1 Gene


Suggested Antigen Peptide Sequences for MDM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8TC05
  • Belongs to the MDM1 family.
genes like me logo Genes that share domains with MDM1: view

No data available for Gene Families for MDM1 Gene

Function for MDM1 Gene

Phenotypes for MDM1 Gene

genes like me logo Genes that share phenotypes with MDM1: view

Animal Model Products

miRNA for MDM1 Gene

miRTarBase miRNAs that target MDM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MDM1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MDM1 Gene

Localization for MDM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDM1 Gene

Subcellular locations from

Jensen Localization Image for MDM1 Gene COMPARTMENTS Subcellular localization image for MDM1 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MDM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MDM1: view

Pathways for MDM1 Gene

SuperPathways for MDM1 Gene

No Data Available

Interacting Proteins for MDM1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000302537 for MDM1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MDM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060041 retina development in camera-type eye IEA --
genes like me logo Genes that share ontologies with MDM1: view

No data available for Pathways by source for MDM1 Gene

Transcripts for MDM1 Gene

Unigene Clusters for MDM1 Gene

Mdm1 nuclear protein homolog (mouse):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MDM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MDM1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP8: -
SP9: - -
SP10: -

ExUns: 18 ^ 19a · 19b

Relevant External Links for MDM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MDM1 Gene

mRNA expression in normal human tissues for MDM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MDM1 Gene

This gene is overexpressed in Colon - Sigmoid (5.0).

Protein differential expression in normal tissues for MDM1 Gene

This gene is overexpressed in Neutrophil (33.9), Peripheral blood mononuclear cells (18.1), and Tlymphocyte (8.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MDM1 Gene

SOURCE GeneReport for Unigene cluster for MDM1 Gene Hs.655702

genes like me logo Genes that share expressions with MDM1: view

Expression partners for MDM1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MDM1 Gene

Orthologs for MDM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MDM1 35
  • 87.01 (n)
  • 81.13 (a)
MDM1 36
  • 80 (a)
(Canis familiaris)
Mammalia MDM1 35
  • 87.4 (n)
  • 82.6 (a)
MDM1 36
  • 81 (a)
(Mus musculus)
Mammalia Mdm1 35
  • 77.95 (n)
  • 71.43 (a)
Mdm1 16
Mdm1 36
  • 69 (a)
(Pan troglodytes)
Mammalia MDM1 35
  • 99.53 (n)
  • 99.16 (a)
MDM1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mdm1 35
  • 77.83 (n)
  • 70.51 (a)
(Monodelphis domestica)
Mammalia MDM1 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia MDM1 36
  • 53 (a)
(Gallus gallus)
Aves MDM1 35
  • 60.55 (n)
  • 50.85 (a)
MDM1 36
  • 44 (a)
(Anolis carolinensis)
Reptilia MDM1 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mdm1 35
  • 55.39 (n)
  • 46.5 (a)
(Danio rerio)
Actinopterygii mdm1 35
  • 49.73 (n)
  • 42.63 (a)
mdm1 36
  • 37 (a)
Species with no ortholog for MDM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDM1 Gene

Gene Tree for MDM1 (if available)
Gene Tree for MDM1 (if available)

Paralogs for MDM1 Gene

No data available for Paralogs for MDM1 Gene

Variants for MDM1 Gene

Sequence variations from dbSNP and Humsavar for MDM1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs962976 - 68,326,847(+) CTTGA(A/G)TAACA reference, missense, utr-variant-3-prime
rs962977 -- 68,327,260(+) AAATC(A/G)GGGGG intron-variant, utr-variant-3-prime
rs973327 -- 68,294,359(-) TAAAT(A/G)TATTT downstream-variant-500B
rs973328 -- 68,294,126(-) AAATC(C/G)TTGGT downstream-variant-500B
rs1038164 -- 68,304,306(+) ATCAA(A/G)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDM1 Gene

Variant ID Type Subtype PubMed ID
esv2480424 CNV Deletion 19546169

Relevant External Links for MDM1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDM1 Gene

Disorders for MDM1 Gene

Relevant External Links for MDM1

Genetic Association Database (GAD)

No disorders were found for MDM1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MDM1 Gene

Publications for MDM1 Gene

  1. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PMID: 22365631) Greenwood T.A. … Kelsoe J.R. (Biol. Psychiatry 2012) 3 48
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for MDM1 Gene

Sources for MDM1 Gene

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