MDM1 Gene
protein-coding GIFtS: 43
GCID: GC12M068688
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Mdm1 nuclear protein homolog (mouse)(Previous names: Mdm4, transformed 3T3 cell double minute 1, p53 binding...)
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Aliases for MDM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Mdm1 Nuclear Protein Homolog (Mouse)1 2 | | Mdm4, Transformed 3T3 Cell Double Minute 1, P53 Binding Protein (Mouse)1 | | Mdm4, Transformed 3T3 Cell Double Minute 1, P53 Binding Protein2 | | Nuclear Protein Double Minute 12 | | Nuclear Protein MDM12 |
Export aliases for MDM1 gene to outside databasesPrevious GC identifers: GC12M068204 GC08U900012 GC12M066975 GC12M065739 |
Summaries for MDM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MDM1: This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in doubleminute (DM) chromatin particles, is amplified in the mouse transformed 3T3 cell line, and the encoded protein is ableto bind to p53. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Mar 2011)
|
Genomic Views for MDM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MDM1 gene promoter: TBP USF1 AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) CUTL1 POU3F2 USF-1 Sox9 MRF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for MDM1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDM1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15MDM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M068688: view genomic region
(about GC identifiers)
Start:
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68,666,223 bp from pter |
End:
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68,726,161 bp from pter |
Size:
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59,939 bases |
Orientation:
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minus strand |
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Proteins for MDM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MDM1_HUMAN, Q8TC05 (See
protein sequence)Recommended Name: Nuclear protein MDM1 Size: 714 amino acids; 80735 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: O43406 Q8WTV9 Q9NR04Alternative splicing: 3 isoforms: Q8TC05-1 Q8TC05-2 Q8TC05-3 Explore the universe of human proteins at neXtProt for MDM1: NX_Q8TC05
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TC05 MDM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001191957.1 NP_001191958.1 NP_059136.2 NP_064513.1 ENSEMBL proteins: ENSP00000350544 ENSP00000443815 ENSP00000302537 ENSP00000445181 ENSP00000391006 ENSP00000446000 ENSP00000377175 ENSP00000408694 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
MDM1 for ontologies About GeneDecksing
MDM1 Antibody Products: Assay Products for MDM1: |
Protein
Domains / Families for MDM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8TC05 UniProtKB/Swiss-Prot: MDM1_HUMAN, Q8TC05Similarity: Belongs to the MDM1 family |
Function for MDM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MDM1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MDM1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): MDM1 (NM_001205028) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MDM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDM1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDM1 |
Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mdm1):
MDM1 for phenotypes About GeneDecksing
|
Pathways & Interactions for MDM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MDM1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for MDM1 (ENSP000003025374) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0060041 | retina development in camera-type eye |
IEA | -- |
MDM1 for ontologies About GeneDecksing
|
Drugs & Compounds for MDM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MDM1 Search CenterWatch for drugs/clinical trials and news about MDM1 
|
Transcripts for MDM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MDM1 gene (4 alternative transcripts): NM_001205028.1 NM_001205029.1 NM_017440.4 NM_020128.2 Unigene Cluster for MDM1: Mdm1 nuclear protein homolog (mouse) Hs.655702 [show with all ESTs]Unigene Representative Sequence: NM_01744015 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357874 ENST00000540418 ENST00000303145(uc010stc.1 uc001stz.2 uc009zqv.1) ENST00000539972 ENST00000411698 ENST00000536313 ENST00000545964 ENST00000538454 ENST00000536997 ENST00000540476 ENST00000541686 ENST00000393543(uc001sua.4 uc010std.2) ENST00000430606 ENST00000545724 ENST00000541087
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MDM1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MDM1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): MDM1 (NM_001205028) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MDM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDM1  |
Additional cDNA sequence: AF007130.1 AF267851.1 AK026745.1 AK297311.1 AK314461.1 BC010622.1 BC022042.1 BC028355.2 BC034945.1 9 DOTS entries: DT.455588 DT.40119716 DT.91669157 DT.100795249 DT.40189581 DT.121154048 DT.75126580 DT.92442553 DT.121154042 24/137 AceView cDNA sequences (see all 137): AW573106 AA889763 BQ015169 AI540218 BX112292 AF267851 BC010622 BM451197 BQ023208 NM_020128 AK026745 BU686774 BX506484 BM766915 AA633597 AA804689 BM127867 AI686371 T65592 BG459739 AI608890 BG460208 NM_017440 BG460569 GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for MDM1 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17 | ^ | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 18 | ^ | 19a | · | 19b | |
| SP1: | |   | |   | |   | |
| SP2: | |   | |   | |   | |
| SP3: | |   | |   | |   | |
| SP4: | |   | |   | |   | |
| SP5: | |   | |   | |   |
ECgene alternative splicing isoforms for MDM1
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Expression for MDM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MDM1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTTGCAGTGT
About this image See MDM1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MDM1
SOURCE GeneReport for Unigene cluster: Hs.655702 SABiosciences Custom PCR Arrays for MDM1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MDM1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MDM1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDM1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDM1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDM1 |
Orthologs for MDM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MDM1 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for MDM1 (if available) TreeFam Gene Tree for MDM1 (if available)  |
Paralogs for MDM1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for MDM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for MDM1 (68666223 - 68726161 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for MDM1 1 CNV: 101550  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MDM1 |
|
Disorders
/ Diseases for MDM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MDM1 for disorders About GeneDecksing
OMIM gene information: 613813
OMIM disorders: --
2 diseases for MDM1: About MalaCardsretinal degeneration retinitis Export disorders for MDM1 gene to outside databases
|
Publications for MDM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MDM1 gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with MDM1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Genome-wide association study of temperament in bipola r disorder reveals significant associations with three novel Loci. (PubMed id 22365631)1 Greenwood T.A....Kelsoe J.R. (2012)
- Age-related retinal degeneration (arrd2) in a novel m ouse model due to a nonsense mutation in the Mdm1 gene. (PubMed id 18805803)1 Chang B....Ayyagari R. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for MDM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing MDM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MDM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MDM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MDM1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MDM1 gene: Search GeneIP for patents involving MDM1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MDM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
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| | | Search Tocris compounds for MDM1 |
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 | | MDM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDM1 |
|  |  |  | | | Search ThermoFisher Antibodies for MDM1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDM1 |
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