Aliases for MDK Gene
External Ids for MDK Gene
Previous HGNC Symbols for MDK Gene
Previous GeneCards Identifiers for MDK Gene
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
GeneCards Summary for MDK Gene
MDK (Midkine) is a Protein Coding gene. Diseases associated with MDK include Epilepsy, Familial Temporal Lobe, 4 and Critical Illness Polyneuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity and heparin binding. An important paralog of this gene is PTN.
UniProtKB/Swiss-Prot for MDK Gene
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).