Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MDH1B Gene

protein-coding   GIFtS: 42
GCID: GC02M207602

Malate Dehydrogenase 1B, NAD (Soluble)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Malate Dehydrogenase 1B, NAD (Soluble)1 2
RP11-95H112
Putative Malate Dehydrogenase 1B2
EC 1.1.1.-3

External Ids:    HGNC: 178361   Entrez Gene: 1307522   Ensembl: ENSG000001384007   UniProtKB: Q5I0G33   

Export aliases for MDH1B gene to outside databases

Previous GC identifers: GC00U991156 GC02M207805 GC02M207428 GC02M207310 GC02M199451


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MDH1B Gene: 
MDH1B (malate dehydrogenase 1B, NAD (soluble)) is a protein-coding gene. Diseases associated with MDH1B include tuberculosis. GO annotations related to this gene include malate dehydrogenase activity and nucleotide binding. An important paralog of this gene is MDH1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MDH1B gene promoter:
         HSF1 (long)   CUTL1   Cdc5   C/EBPalpha   AREB6   POU2F1   POU2F1a   HFH-1   Sox9   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MDH1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDH1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

MDH1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDH1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M207602:  view genomic region     (about GC identifiers)

Start:
207,602,487 bp from pter      End:
207,630,271 bp from pter
Size:
27,785 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MDH1B_HUMAN, Q5I0G3 (See protein sequence)
Recommended Name: Putative malate dehydrogenase 1B  
Size: 518 amino acids; 58651 Da
Secondary accessions: A8K8M1 Q53TK9 Q8IV51
Alternative splicing: 3 isoforms:  Q5I0G3-1   Q5I0G3-2   Q5I0G3-3   (Ref.4 (AAH33509) sequence is in conflict in position: 261:I->T)

Explore the universe of human proteins at neXtProt for MDH1B: NX_Q5I0G3

Explore proteomics data for MDH1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5I0G3

  • MDH1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MDH1B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001034934.1  NP_001269869.1  

    ENSEMBL proteins: 
     ENSP00000363533   ENSP00000392464   ENSP00000416577   ENSP00000389916   ENSP00000403810  
     ENSP00000376049  

    Human Recombinant Protein Products for MDH1B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MDH1B
    OriGene Protein Over-expression Lysate for MDH1B
    OriGene MassSpec for MDH1B 
    OriGene Custom Protein Services for MDH1B
    GenScript Custom Purified and Recombinant Proteins Services for MDH1B
    Novus Biologicals MDH1B Protein
    Novus Biologicals MDH1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MDH1B 


    MDH1B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MDH1B
    GenScript Custom Superior Antibodies Services for MDH1B
    Novus Biologicals MDH1B Antibodies
    Search for Antibodies for MDH1B at Abcam
    Cloud-Clone Corp. Antibodies for MDH1B 
    Search ThermoFisher Antibodies for MDH1B
    LSBio Antibodies in human, mouse, rat for MDH1B 

    Assay Products for MDH1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MDH1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MDH1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MDH1B 
    Cloud-Clone Corp. CLIAs for MDH1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR010945 Malate_DH_type2
     IPR022383 Lactate/malate_DH_C
     IPR015955 Lactate_DH/Glyco_Ohase_4_C
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q5I0G3

    ProtoNet protein and cluster: Q5I0G3

    1 Blocks protein domain: IPB008267 Malate dehydrogenase

    UniProtKB/Swiss-Prot: MDH1B_HUMAN, Q5I0G3
    Similarity: Belongs to the LDH/MDH superfamily. MDH type 2 family


    MDH1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 1.1.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0016615malate dehydrogenase activity IEA--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA--
         
    MDH1B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MDH1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MDH1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MDH1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MDH1B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDH1B
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MDH1B:
    hsa-miR-146a* hsa-miR-549 hsa-miR-607
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MDH1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDH1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MDH1B
    Sirion Biotech Customized adenovirus for overexpression of MDH1B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MDH1B (see all 7)
    OriGene ORF clones in mouse, rat for MDH1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MDH1B (NM_001039845)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDH1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDH1B
    Sirion Biotech Customized lentivirus for stable overexpression of MDH1B 
                         Customized lentivirus expression plasmids for stable overexpression of MDH1B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MDH1B
    Search LifeMap BioReagents cell lines for MDH1B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDH1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MDH1B

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006099tricarboxylic acid cycle IEA--
    GO:0006108malate metabolic process IEA--
    GO:0055114oxidation-reduction process ----

    MDH1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MDH1B

    Search CenterWatch for drugs/clinical trials and news about MDH1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MDH1B gene (3 alternative transcripts): 
    NM_206892.1  NM_001039845.2  NM_001282940.1  

    Unigene Cluster for MDH1B:

    Malate dehydrogenase 1B, NAD (soluble)
    Hs.147816  [show with all ESTs]
    Unigene Representative Sequence: NM_001039845
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374412(uc010ziw.2 uc002vbs.3 uc010fui.3) ENST00000432911(uc002vbt.3)
    ENST00000449792(uc021vvm.1) ENST00000454776 ENST00000436472 ENST00000471988
    ENST00000392214
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDH1B
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MDH1B:
    hsa-miR-146a* hsa-miR-549 hsa-miR-607
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MDH1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDH1B
    Clone
    Products:
         
    OriGene clones in human, mouse for MDH1B (see all 7)
    OriGene ORF clones in mouse, rat for MDH1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MDH1B (NM_001039845)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDH1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDH1B
    Sirion Biotech Customized lentivirus for stable overexpression of MDH1B 
                         Customized lentivirus expression plasmids for stable overexpression of MDH1B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MDH1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MDH1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDH1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDH1B

    Additional mRNA sequence: 

    AK058070.1 AK292378.1 AK292386.1 AK302250.1 AK308257.1 AK309144.1 BC033509.1 BC088356.1 

    5 DOTS entries:

    DT.40206723  DT.92003755  DT.86847255  DT.91707010  DT.120991682 

    24/41 AceView cDNA sequences (see all 41):

    AI783669 BF221699 BM717644 AK058070 CR593018 AI076012 BF056314 BF979825 
    BU844500 AW118920 N66501 BX369192 AI221878 AA758811 BX369191 AI025196 
    BX371624 NM_206892 AA889831 CD251991 BC033509 BF197105 CD104917 BU942783 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MDH1B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                          -                                   -                     
    SP2:                          -     -     -                                             
    SP3:                          -     -     -                                             
    SP4:                                                                                    


    ECgene alternative splicing isoforms for MDH1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MDH1B expression in normal human tissues (normalized intensities)      MDH1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MDH1B Expression
    About this image


    MDH1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)

    See MDH1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MDH1B

    SOURCE GeneReport for Unigene cluster: Hs.147816
        SABiosciences Expression via Pathway-Focused PCR Arrays including MDH1B: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MDH1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MDH1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDH1B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDH1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDH1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MDH1B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mdh1b1 , 5 malate dehydrogenase 1B, NAD (soluble)1, 5 77.25(n)1
    72.34(a)1
      1 (32.31 cM)5
    766681  NM_029696.41  NP_083972.31 
     636988195 
    chicken
    (Gallus gallus)
    Aves MDH1B1 malate dehydrogenase 1B, NAD (soluble) 63.4(n)
    57.14(a)
      424097  XM_421952.3  XP_421952.1 
    lizard
    (Anolis carolinensis)
    Reptilia MDH1B6
    malate dehydrogenase 1B, NAD (soluble)
    51(a)
    1 ↔ 1
    GL343208.1(345990-372301)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1539221 zgc:153922 55.34(n)
    47.43(a)
      767794  NM_001076761.1  NP_001070229.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mdh16
    Malate dehydrogenase 1
    26(a)
    1 → many
    2L(10393847-10396275)
    worm
    (Caenorhabditis elegans)
    Secernentea mdh-16
    Protein MDH-1, isoform a
    26(a)
    1 → many
    V(6515276-6516528)


    ENSEMBL Gene Tree for MDH1B (if available)
    TreeFam Gene Tree for MDH1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MDH1B gene
    MDH12  
    1 SIMAP similar gene for MDH1B using alignment to 3 protein entries:     MDH1B_HUMAN (see all proteins):
    MDH1

    MDH1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/626 SNPs in MDH1B are shown (see all 626)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0647294
    ----see VAR_0647292 L I mis40--------
    rs1436312111,2
    --207601992(+) TCTGCA/GTAAAG 1 -- ds50010--------
    rs46756331,2
    C,F,A,H--207602049(+) CTTGGG/ATTGAG 1 -- ds500113Minor allele frequency- A:0.38NA WA CSA EA 515
    rs1480861661,2
    --207602050(+) TTGGGC/TTGAGG 1 -- ds50010--------
    rs1419096721,2
    --207602104(+) AAATCA/GATGTC 1 -- ds50010--------
    rs557142161,2
    C,F--207602117(+) TAACAC/TGGATA 1 -- ds50012Minor allele frequency- T:0.15WA 120
    rs1460849251,2
    --207602216(+) TATGAA/TGGTGC 1 -- ds50010--------
    rs1389737631,2
    C--207602234(+) ATGCAA/GAAGAT 1 -- ds50010--------
    rs1147464341,2
    C,F--207602299(+) AAACAT/CACAGA 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs21938841,2
    C,F,A,H--207602424(-) AAAGCA/GGTAAT 1 -- ds500123Minor allele frequency- G:0.48NS EA NA WA CSA 3837

    HapMap Linkage Disequilibrium report for MDH1B (207602487 - 207630271 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MDH1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv875739CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MDH1B
    DNA2.0 Custom Variant and Variant Library Synthesis for MDH1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for MDH1B:    About MalaCards
    tuberculosis    


    MDH1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): MDH1B
    Human Genome Epidemiology (HuGE) Navigator: MDH1B (1 document)

    Export disorders for MDH1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MDH1B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MDH1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 130752 HGNC: 17836 AceView: MDH1B Ensembl:ENSG00000138400 euGenes: HUgn130752
    ECgene: MDH1B H-InvDB: MDH1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MDH1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MDH1B gene:
    Search GeneIP for patents involving MDH1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MDH1B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MDH1B  
     OriGene MassSpec something-or-other for MDH1B   OriGene clones in human, mouse for MDH1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for MDH1B   OriGene Purified Protein for MDH1B  
     OriGene ORF clones in mouse, rat for MDH1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MDH1B   OriGene Custom Protein Services for MDH1B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MDH1B
     QIAGEN SeqTarget long-range PCR primers for resequencing MDH1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDH1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDH1B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDH1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDH1B
     GenScript Custom Purified and Recombinant Proteins Services for MDH1B GenScript cDNA clones with any tag delivered in your preferred vector for MDH1B
     GenScript Custom Assay Services for MDH1B GenScript Custom Superior Antibodies Services for MDH1B
     GenScript Custom overexpressing Cell Line Services for MDH1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MDH1B promoter
     Search Chromatin IP Primers for MDH1B
     RT2 qPCR Primer Assay in human, mouse, rat MDH1B
     Search GNC Networks for MDH1B
     SABiosciences PCR Arrays including human, mouse, rat MDH1B
     Search Tocris compounds for MDH1B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MDH1B antibodies
     MDH1B proteins
     MDH1B lysates
     Search for Antibodies for MDH1B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MDH1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MDH1B
     Antibodies for MDH1B
     ELISAs for MDH1B
     CLIAs for MDH1B
     Search LifeMap BioReagents cell lines for MDH1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDH1B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MDH1B
     Browse SwitchGear Promoter luciferase reporter plasmids for MDH1B
     Search ThermoFisher Antibodies for MDH1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDH1B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MDH1B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MDH1B
    Customized:
     lentivirus for stable overexpression of MDH1B
     lentivirus expression plasmids for stable overexpression of MDH1B
     adenovirus for overexpression of MDH1B
     LSBio Antibodies in human, mouse, rat for MDH1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MDH1B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4