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Aliases for MDH1 Gene

Aliases for MDH1 Gene

  • Malate Dehydrogenase 1, NAD (Soluble) 2 3
  • Cytosolic Malate Dehydrogenase 3 4
  • Diiodophenylpyruvate Reductase 3 4
  • EC 1.1.1.37 4 63
  • MDHA 3 4
  • Epididymis Secretory Protein Li 32 3
  • Malate Dehydrogenase, Cytoplasmic 3
  • Soluble Malate Dehydrogenase 3
  • EC 1.1.1.96 4
  • HEL-S-32 3
  • MGC:1375 3
  • MDH-S 3
  • MOR2 3

External Ids for MDH1 Gene

Previous GeneCards Identifiers for MDH1 Gene

  • GC02P063944
  • GC02P063773
  • GC02P063790
  • GC02P063727
  • GC02P063669

Summaries for MDH1 Gene

Entrez Gene Summary for MDH1 Gene

  • Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

GeneCards Summary for MDH1 Gene

MDH1 (Malate Dehydrogenase 1, NAD (Soluble)) is a Protein Coding gene. Diseases associated with MDH1 include schizophrenia. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include NAD binding and L-malate dehydrogenase activity. An important paralog of this gene is MDH1B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDH1 Gene

Genomics for MDH1 Gene

Regulatory Elements for MDH1 Gene

Genomic Location for MDH1 Gene

Start:
63,588,609 bp from pter
End:
63,607,197 bp from pter
Size:
18,589 bases
Orientation:
Plus strand

Genomic View for MDH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MDH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDH1 Gene

Proteins for MDH1 Gene

  • Protein details for MDH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40925-MDHC_HUMAN
    Recommended name:
    Malate dehydrogenase, cytoplasmic
    Protein Accession:
    P40925
    Secondary Accessions:
    • B2R5V5
    • B4DUN2
    • B7Z3I7
    • F5H098
    • Q6I9V0

    Protein attributes for MDH1 Gene

    Size:
    334 amino acids
    Molecular mass:
    36426 Da
    Quaternary structure:
    • Homodimer

    Alternative splice isoforms for MDH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDH1 Gene

Proteomics data for MDH1 Gene at MOPED

Post-translational modifications for MDH1 Gene

  • Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.
  • ISGylated.
  • Ubiquitination at Lys118, Lys125, Lys142, Lys164, Lys205, Lys214, Lys298, and Lys318
  • Modification sites at PhosphoSitePlus

Domains for MDH1 Gene

Suggested Antigen Peptide Sequences for MDH1 Gene

Graphical View of Domain Structure for InterPro Entry

P40925

UniProtKB/Swiss-Prot:

MDHC_HUMAN :
  • P40925
Family:
  • Belongs to the LDH/MDH superfamily. MDH type 2 family.
genes like me logo Genes that share domains with MDH1: view

No data available for Gene Families for MDH1 Gene

Function for MDH1 Gene

Molecular function for MDH1 Gene

GENATLAS Biochemistry: malate dehydrogenase,NAD,soluble,same as KETAR (keto acid reductase,alpha-1)
UniProtKB/Swiss-Prot CatalyticActivity: (S)-malate + NAD(+) = oxaloacetate + NADH.
UniProtKB/Swiss-Prot CatalyticActivity: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH.

Enzyme Numbers (IUBMB) for MDH1 Gene

Gene Ontology (GO) - Molecular Function for MDH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004470 malic enzyme activity TAS 8786100
GO:0016491 oxidoreductase activity --
GO:0016615 malate dehydrogenase activity --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
genes like me logo Genes that share ontologies with MDH1: view

Phenotypes for MDH1 Gene

genes like me logo Genes that share phenotypes with MDH1: view

miRNA for MDH1 Gene

miRTarBase miRNAs that target MDH1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MDH1 Gene

Localization for MDH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDH1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MDH1 Gene COMPARTMENTS Subcellular localization image for MDH1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
chloroplast 3
mitochondrion 3
peroxisome 3
endoplasmic reticulum 2
plasma membrane 2
vacuole 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MDH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MDH1: view

Pathways for MDH1 Gene

genes like me logo Genes that share pathways with MDH1: view

Gene Ontology (GO) - Biological Process for MDH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
GO:0006099 tricarboxylic acid cycle IEA --
genes like me logo Genes that share ontologies with MDH1: view

Compounds for MDH1 Gene

(5) HMDB Compounds for MDH1 Gene

Compound Synonyms Cas Number PubMed IDs
L-Malic acid
  • (-)-(S)-Malate
97-67-6
Malic acid
  • 2-Hydroxybutanedioic acid
6915-15-7
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
Oxalacetic acid
  • 2-Ketosuccinate
328-42-7

(3) Drugbank Compounds for MDH1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-Monophosphoadenosine 5'-Diphosphoribose
target
NADH
  • beta-DPNH
606-68-8 target
Nicotinamide-Adenine-Dinucleotide
53-84-9 target

(8) Novoseek inferred chemical compound relationships for MDH1 Gene

Compound -log(P) Hits PubMed IDs
malate 89.9 37
tartronate 86.3 1
oxaloacetate 73.4 1
nadh 53 5
lactate 44.8 5
genes like me logo Genes that share compounds with MDH1: view

Transcripts for MDH1 Gene

Unigene Clusters for MDH1 Gene

Malate dehydrogenase 1, NAD (soluble):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDH1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - - -

Relevant External Links for MDH1 Gene

GeneLoc Exon Structure for
MDH1
ECgene alternative splicing isoforms for
MDH1

Expression for MDH1 Gene

mRNA expression in normal human tissues for MDH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MDH1 Gene

This gene is overexpressed in Heart - Left Ventricle (6.9) and Heart - Atrial Appendage (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MDH1 Gene

SOURCE GeneReport for Unigene cluster for MDH1 Gene Hs.526521

genes like me logo Genes that share expressions with MDH1: view

No data available for mRNA Expression by UniProt/SwissProt for MDH1 Gene

Orthologs for MDH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MDH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MDH1 35
  • 99.72 (n)
  • 99.72 (a)
MDH1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MDH1 35
  • 93.69 (n)
  • 95.5 (a)
MDH1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MDH1 35
  • 93.59 (n)
  • 95.2 (a)
MDH1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mdh1 35
  • 90.29 (n)
  • 96.4 (a)
Mdh1 16
Mdh1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MDH1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDH1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdh1 35
  • 89.19 (n)
  • 97 (a)
chicken
(Gallus gallus)
Aves MDH1 35
  • 81.83 (n)
  • 90.66 (a)
MDH1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MDH1 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68659 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mdh1 35
  • 79.09 (n)
  • 87.58 (a)
Str.84 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3779 35
zebrafish
(Danio rerio)
Actinopterygii mdh1aa 36
  • 78 (a)
OneToOne
mdh1b 35
  • 73.43 (n)
  • 79.39 (a)
wufk59d03 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009510 35
  • 60.56 (n)
  • 66.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mdh1 35
  • 62.44 (n)
  • 66.47 (a)
Mdh1 36
  • 65 (a)
OneToMany
CG5362 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea mdh-1 35
  • 59.43 (n)
  • 60.86 (a)
mdh-1 36
  • 59 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7946 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G04410 35
  • 60.69 (n)
  • 62.01 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.746 35
corn
(Zea mays)
Liliopsida Zm.5727 35
rice
(Oryza sativa)
Liliopsida Os10g0478200 35
  • 60.99 (n)
  • 59.88 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.24987 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4600 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8282 36
  • 64 (a)
OneToOne
Species with no ortholog for MDH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MDH1 Gene

ENSEMBL:
Gene Tree for MDH1 (if available)
TreeFam:
Gene Tree for MDH1 (if available)

Paralogs for MDH1 Gene

Paralogs for MDH1 Gene

Selected SIMAP similar genes for MDH1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for MDH1 Gene

genes like me logo Genes that share paralogs with MDH1: view

Variants for MDH1 Gene

Sequence variations from dbSNP and Humsavar for MDH1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1255 -- 63,598,800(-) GAAGA(A/G)GTGGA intron-variant
rs14777 -- 63,606,974(+) ATTTC(C/T)TTCCT missense, reference
rs262470 -- 63,603,425(+) AGTTT(C/T)TTCTC intron-variant
rs262471 -- 63,603,735(+) TCACC(A/G)CAACC intron-variant
rs262472 -- 63,606,482(+) TCATT(A/G)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDH1 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855

Relevant External Links for MDH1 Gene

HapMap Linkage Disequilibrium report
MDH1
Human Gene Mutation Database (HGMD)
MDH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDH1 Gene

Disorders for MDH1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MDH1 Gene including...

Search for MDH1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for MDH1 Gene

Disease -log(P) Hits PubMed IDs
dilated cardiomyopathy 24.9 1
schizophrenia 0 4

Relevant External Links for MDH1

Genetic Association Database (GAD)
MDH1
Human Genome Epidemiology (HuGE) Navigator
MDH1
genes like me logo Genes that share disorders with MDH1: view

No data available for UniProtKB/Swiss-Prot for MDH1 Gene

Publications for MDH1 Gene

  1. Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase (MDH1). (PMID: 8786100) Tanaka T. … Nakamura Y. (Genomics 1996) 3 4 23
  2. Mor2, supernatant malate dehydrogenase, is linked to wa2 and Hba on mouse chromosome 11 in a region of homology with human chromosome 2p. (PMID: 7698769) Ball S.T. … Peters J. (Genomics 1994) 3 23
  3. Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase. (PMID: 10190973) Fahien L.A. … Chobanian M. (Arch. Biochem. Biophys. 1999) 3 23
  4. Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1). (PMID: 15565635) Lo A.S. … Waye M.M. (J. Cell. Biochem. 2005) 3 23
  5. A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress. (PMID: 19229245) Lee S.M. … Youn H.D. (Cell Death Differ. 2009) 3 23

Products for MDH1 Gene

Sources for MDH1 Gene

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