Aliases for MDH1 Gene
External Ids for MDH1 Gene
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
GeneCards Summary for MDH1 Gene
MDH1 (Malate Dehydrogenase 1, NAD (Soluble)) is a Protein Coding gene. Diseases associated with MDH1 include schizophrenia. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include NAD binding and L-malate dehydrogenase activity. An important paralog of this gene is MDH1B.