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MDGA2 Gene

protein-coding   GIFtS: 52
GCID: GC14M047309

MAM Domain Containing Glycosylphosphatidylinositol Anchor...

(Previous name: MAM domain containing 1)
(Previous symbol: MAMDC1)
  See MDGA2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAM Domain Containing Glycosylphosphatidylinositol Anchor 21 2
MAMDC11 2 3
MAM Domain Containing 11 2
c14_52862
MAM Domain-Containing Glycosylphosphatidylinositol Anchor Protein 22
MAM Domain-Containing Protein 13

External Ids:    HGNC: 198351   Entrez Gene: 1613572   Ensembl: ENSG000001399157   OMIM: 6111285   UniProtKB: Q7Z5533   

Export aliases for MDGA2 gene to outside databases

Previous GC identifers: GC14M046380 GC14M027426


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MDGA2 Gene:
MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a protein-coding gene. Diseases associated with MDGA2 include benign epilepsy with centrotemporal spikes. An important paralog of this gene is MAMDC4.

UniProtKB/Swiss-Prot: MDGA2_HUMAN, Q7Z553
Function: May be involved in cell-cell interactions (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MDGA2 gene promoter:
         RFX1   p53   MAZR   Brachyury   Nkx2-5   MEF-2A   CREB   deltaCREB   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMDGA2 promoter sequence
   Search Chromatin IP Primers for MDGA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MDGA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.3   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21.2

MDGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDGA2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M047309:  view genomic region     (about GC identifiers)

Start:
47,308,826 bp from pter      End:
48,144,157 bp from pter
Size:
835,332 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MDGA2_HUMAN, Q7Z553 (See protein sequence)
Recommended Name: MAM domain-containing glycosylphosphatidylinositol anchor protein 2 precursor  
Size: 956 amino acids; 107436 Da
Subunit: Interacts (through the Ig-like domains) with NLGN2 (By similarity)
Sequence caution: Sequence=AAP97010.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: F6W3S7 J3KPX6
Alternative splicing: 3 isoforms:  Q7Z553-1   Q7Z553-2   Q7Z553-3   (No experimental confirmation available. Ref.2 (AK309211) sequence is in conflict in position: 50:G->S)

Explore the universe of human proteins at neXtProt for MDGA2: NX_Q7Z553

Explore proteomics data for MDGA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn92, Asn213, Asn237, Asn434, Asn443, Asn504, Asn610, Asn703

  • See MDGA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001106970.3  NP_878250.2  

    ENSEMBL proteins: 
     ENSP00000382178   ENSP00000349925   ENSP00000452593   ENSP00000450827   ENSP00000434991  
     ENSP00000452515   ENSP00000405456   ENSP00000382168  

    MDGA2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MDGA2

     
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    LSBio Antibodies in human, mouse, rat for MDGA2

    MDGA2 Assay Products:

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    Cloud-Clone Corp. ELISAs for MDGA2
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    Search eBioscience for ELISAs for MDGA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z553

    ProtoNet protein and cluster: Q7Z553

    3 Blocks protein domains:
    IPB000998 MAM domain signature
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: MDGA2_HUMAN, Q7Z553
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 6 Ig-like (immunoglobulin-like) domains
    Similarity: Contains 1 MAM domain


    Find genes that share domains with MDGA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDGA2_HUMAN, Q7Z553
    Function: May be involved in cell-cell interactions (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MDGA2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MDGA2:
     Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mdga2):
     cellular  craniofacial  embryogenesis  limbs/digits/tail  skeleton 

    Find genes that share phenotypes with MDGA2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MDGA2
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    miRNA
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    miRTarBase miRNAs that target MDGA2:
    hsa-mir-335-5p (MIRT017643)

    Block miRNA regulation of human, mouse, rat MDGA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MDGA2 (see all 75):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-520f hsa-miR-199a-3p hsa-miR-4267 hsa-miR-3622b-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidMDGA2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MDGA2
    Predesigned siRNA for gene silencing in human, mouse, rat MDGA2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MDGA2 (NM_182830)
    Sino Biological Human cDNA Clone for MDGA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDGA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDGA2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDGA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MDGA2_HUMAN, Q7Z553: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with MDGA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MDGA2
    Interactions:

        Search GeneGlobe Interaction Network for MDGA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for MDGA2 (ENSP000003821784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRPAENSP000003483074STRING: ENSP00000348307
    NCR3LG1ENSP000003416374STRING: ENSP00000341637
    TAPBPLENSP000002665564STRING: ENSP00000266556
    PVRENSP000004020604STRING: ENSP00000402060
    --ENSP000003687484STRING: ENSP00000368748
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007389pattern specification process ----
    GO:0021522spinal cord motor neuron differentiation ISS15019943

    Find genes that share ontologies with MDGA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MDGA2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MDGA2 gene (2 alternative transcripts): 
    NM_001113498.2  NM_182830.4  

    Unigene Cluster for MDGA2:

    MAM domain containing glycosylphosphatidylinositol anchor 2
    Hs.436380  [show with all ESTs]
    Unigene Representative Sequence: NM_001113498
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399232 ENST00000357362 ENST00000557238(uc010ani.3) ENST00000557516
    ENST00000555521 ENST00000554762 ENST00000482848 ENST00000486952 ENST00000472499
    ENST00000426342(uc001wwi.4) ENST00000399222
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MDGA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MDGA2 (see all 75):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-520f hsa-miR-199a-3p hsa-miR-4267 hsa-miR-3622b-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidMDGA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MDGA2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MDGA2 (NM_182830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDGA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDGA2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MDGA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MDGA2
      QuantiTect SYBR Green Assays in human, mouse, rat MDGA2
      QuantiFast Probe-based Assays in human, mouse, rat MDGA2

    Additional mRNA sequence: 

    AK123307.1 AK309211.1 AY328482.1 AY358125.1 AY369208.1 BC028193.1 BC142947.1 BX538065.1 

    4 DOTS entries:

    DT.91687677  DT.101982721  DT.120750063  DT.40265163 

    Selected AceView cDNA sequences (see all 45):

    BM677591 AL700554 R19534 AY328482 BU634335 BF726137 H10594 BF726138 
    R12082 NM_182830 C15449 AK123307 BU619918 AY358125 Z40254 AY369208 
    BF977913 F07150 BI827613 BG203457 BC028193 N22833 D61241 AW470823 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MDGA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGCTGGA
    MDGA2 Expression
    About this image


    MDGA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    MDGA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MDGA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436380

    UniProtKB/Swiss-Prot: MDGA2_HUMAN, Q7Z553
    Tissue specificity: Detected in Leydig cells, syncytiotrophoblast, duodenal villi epithelial cells and neutrophils
    from kidney and cutaneous squamous cell carcinoma (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDGA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MDGA2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mdga21 , 5 MAM domain containing glycosylphosphatidylinositol more1, 5 91.35(n)1
    98.74(a)1
      12 (27.63 cM)5
    3207721  NM_001193266.11  NP_001180195.21 
     664695685 
    chicken
    (Gallus gallus)
    Aves MDGA21 MAM domain containing glycosylphosphatidylinositol more 78.97(n)
    92.49(a)
      423563  XM_421454.4  XP_421454.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    GL343352.1(543025-804036)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mdga21 MAM domain containing glycosylphosphatidylinositol more 76.78(n)
    82.71(a)
      100490514  XM_002942609.2  XP_002942655.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mamdc12 MAM domain containing 1 73.98(n)   368826  BI979700.1 


    ENSEMBL Gene Tree for MDGA2 (if available)
    TreeFam Gene Tree for MDGA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MDGA2 gene
    MAMDC42  MDGA12  MALRD12  ENSG000002727812  MAMDC22  
    4 SIMAP similar genes for MDGA2 using alignment to 6 protein entries:     MDGA2_HUMAN (see all proteins):
    MDGA1    MUSK    DIET1    NRP1

    Find genes that share paralogs with MDGA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MDGA2 (see all 16515)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1416394761,2
    Cuntested148092018(+) GGGAAA/G/TTAGAT 1 -- int10--------
    rs561730121,2
    C--27607332(+) AAATG-/CG    
       GATCT
    TCAAT
    2 -- int10--------
    rs357773291,2
    C--27608845(+) ATTAA-/TAGAGTA 2 -- int12Minor allele frequency- TA:0.25NA 4
    rs1176454911,2
    F--28263881(+) ATACAT/CGTGTT 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs344772691,2
    C--28357141(+) TTTTT-/TTT   
       
    /TTTT
    GAGAC
    4 -- int1 cds11NA 2
    rs286901381,2
    C,F--47308480(+) TGCTTA/TGTAGT 2 -- ds50012Minor allele frequency- T:0.09WA 120
    rs29332031,2
    C,F,A,H--47308491(+) AGGATC/TGAAAC 2 -- ds500125Minor allele frequency- T:0.41NS EA NA WA CSA 2772
    rs29332041,2
    C,F,H--47308540(+) AATAAT/CAGGAC 2 -- ds500116Minor allele frequency- C:0.01NS EA NA WA CSA 794
    rs1466154461,2
    --47308576(+) ACATGC/TATATT 2 -- ds50010--------
    rs285272931,2
    C,F--47308744(+) AATCAA/GTTAAA 2 -- ds50012Minor allele frequency- G:0.08WA 120

    HapMap Linkage Disequilibrium report for MDGA2 (47308826 - 47558826 bp, first 250kb of MDGA2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MDGA2 (see all 45):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748688CNV Deletion23290073
    esv2678726CNV Deletion23128226
    esv2669315CNV Deletion23128226
    esv2677746CNV Deletion23128226
    esv2748690CNV Deletion23290073
    esv2748689CNV Deletion23290073
    esv269991CNV Insertion20981092
    esv269528CNV Insertion20981092
    nsv507746CNV Insertion20534489
    esv267565CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MDGA2
    DNA2.0 Custom Variant and Variant Library Synthesis for MDGA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611128    OMIM disorders: --

    1 disease for MDGA2:    
    About MalaCards
    benign epilepsy with centrotemporal spikes

    2 diseases from the University of Copenhagen DISEASES database for MDGA2:
    Benign epilepsy with centrotemporal spikes     Autistic disorder

    Find genes that share disorders with MDGA2           About GenesLikeMe

    Genetic Association Database (GAD): MDGA2
    Human Genome Epidemiology (HuGE) Navigator: MDGA2 (8 documents)

    Export disorders for MDGA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MDGA2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with MDGA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE). (PubMed id 19997561)1, 2, 4, 9 Hellquist A....Kere J. (PLoS ONE 2009)
    2. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (Pharmacogenomics J. 2013)
    3. Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression. (PubMed id 22445761)1, 4 Kurose K....Saito Y. (Psychiatry Res 2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. (PubMed id 19557195)1, 4 Bucan M....Hakonarson H. (PLoS Genet. 2009)
    7. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. (PubMed id 18762592)1, 4 van den Oord E.J....Rujescu D. (Arch. Gen. Psychiatry 2008)
    8. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1, 4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    9. Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization. (PubMed id 15019943)1, 3 Litwack E.D....O'Leary D.D. (Mol. Cell. Neurosci. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 161357 HGNC: 19835 AceView: MAMDC1 Ensembl:ENSG00000139915 euGenes: HUgn161357
    ECgene: MDGA2 H-InvDB: MDGA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MDGA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MDGA2 gene:
    Search GeneIP for patents involving MDGA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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