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Aliases for MDGA1 Gene

Aliases for MDGA1 Gene

  • MAM Domain Containing Glycosylphosphatidylinositol Anchor 1 2 3
  • Glycosylphosphatidylinositol-MAM 3 4
  • MAM Domain-Containing Protein 3 3 4
  • GPI And MAM Protein 3 4
  • MAMDC3 3 4
  • GPIM 3 4
  • Glycosyl-Phosphatidyl-Inositol-MAM 3

External Ids for MDGA1 Gene

Previous GeneCards Identifiers for MDGA1 Gene

  • GC06U990326
  • GC06M037596
  • GC06M037647
  • GC06M037708
  • GC06M037319

Summaries for MDGA1 Gene

GeneCards Summary for MDGA1 Gene

MDGA1 (MAM Domain Containing Glycosylphosphatidylinositol Anchor 1) is a Protein Coding gene. An important paralog of this gene is MALRD1.

UniProtKB/Swiss-Prot for MDGA1 Gene

  • Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDGA1 Gene

Genomics for MDGA1 Gene

Regulatory Elements for MDGA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MDGA1 Gene

Chromosome:
6
Start:
37,630,679 bp from pter
End:
37,699,306 bp from pter
Size:
68,628 bases
Orientation:
Minus strand

Genomic View for MDGA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MDGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDGA1 Gene

Proteins for MDGA1 Gene

  • Protein details for MDGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFP4-MDGA1_HUMAN
    Recommended name:
    MAM domain-containing glycosylphosphatidylinositol anchor protein 1
    Protein Accession:
    Q8NFP4
    Secondary Accessions:
    • A6NHG0
    • Q8NBE3

    Protein attributes for MDGA1 Gene

    Size:
    955 amino acids
    Molecular mass:
    105790 Da
    Quaternary structure:
    • Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its Ig-like domains with proteins in differentiating muscle (By similarity). Interacts (through the Ig-like domains) with NLGN2.
    SequenceCaution:
    • Sequence=BAC03502.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MDGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDGA1 Gene

Proteomics data for MDGA1 Gene at MOPED

Post-translational modifications for MDGA1 Gene

  • Glycosylation at Asn 42, Asn 90, Asn 235, Asn 247, Asn 257, Asn 307, Asn 331, Asn 432, Asn 655, Asn 747, and Asn 826
  • Modification sites at PhosphoSitePlus

Other Protein References for MDGA1 Gene

No data available for DME Specific Peptides for MDGA1 Gene

Domains & Families for MDGA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFP4

UniProtKB/Swiss-Prot:

MDGA1_HUMAN :
  • Contains 1 fibronectin type-III domain.
Domain:
  • Contains 1 fibronectin type-III domain.
  • Contains 6 Ig-like (immunoglobulin-like) domains.
  • Contains 1 MAM domain.
genes like me logo Genes that share domains with MDGA1: view

Function for MDGA1 Gene

Molecular function for MDGA1 Gene

UniProtKB/Swiss-Prot Function:
Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.

Gene Ontology (GO) - Molecular Function for MDGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MDGA1: view

Phenotypes for MDGA1 Gene

MGI mutant phenotypes for MDGA1:
inferred from 1 alleles
GenomeRNAi human phenotypes for MDGA1:
genes like me logo Genes that share phenotypes with MDGA1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MDGA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MDGA1 Gene

Localization for MDGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDGA1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Associated with lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MDGA1 Gene COMPARTMENTS Subcellular localization image for MDGA1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for MDGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane --
GO:0046658 anchored component of plasma membrane ISS 15019943
genes like me logo Genes that share ontologies with MDGA1: view

Pathways & Interactions for MDGA1 Gene

SuperPathways for MDGA1 Gene

No Data Available

Interacting Proteins for MDGA1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000402584%0d%0a9606.ENSP00000317980%0d%0a9606.ENSP00000325929%0d%0a
Selected Interacting proteins: ENSP00000402584 for MDGA1 Gene via STRING

Gene Ontology (GO) - Biological Process for MDGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration ISS --
GO:0007420 brain development ISS 15019943
GO:0021527 spinal cord association neuron differentiation ISS 15019943
GO:0021799 cerebral cortex radially oriented cell migration IEA --
GO:0051964 negative regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with MDGA1: view

No data available for Pathways by source and SIGNOR curated interactions for MDGA1 Gene

Drugs & Compounds for MDGA1 Gene

No Compound Related Data Available

Transcripts for MDGA1 Gene

Unigene Clusters for MDGA1 Gene

MAM domain containing glycosylphosphatidylinositol anchor 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MDGA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MDGA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1:
SP2: - -
SP3: -
SP4:
SP5:
SP6: - -
SP7: -
SP8: -
SP9:
SP10:
SP11: -
SP12: -

ExUns: 18b · 18c ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MDGA1 Gene

GeneLoc Exon Structure for
MDGA1
ECgene alternative splicing isoforms for
MDGA1

Expression for MDGA1 Gene

mRNA expression in normal human tissues for MDGA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MDGA1 Gene

This gene is overexpressed in Brain - Cerebellum (x19.2) and Brain - Cerebellar Hemisphere (x16.8).

Protein differential expression in normal tissues from HIPED for MDGA1 Gene

This gene is overexpressed in Fetal Brain (56.4) and Retina (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MDGA1 Gene



SOURCE GeneReport for Unigene cluster for MDGA1 Gene Hs.437993

mRNA Expression by UniProt/SwissProt for MDGA1 Gene

Q8NFP4-MDGA1_HUMAN
Tissue specificity: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues
genes like me logo Genes that share expression patterns with MDGA1: view

Protein tissue co-expression partners for MDGA1 Gene

Primer Products

In Situ Assay Products

Orthologs for MDGA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDGA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MDGA1 35
  • 92.36 (n)
  • 97.28 (a)
MDGA1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MDGA1 35
  • 92.42 (n)
  • 97.27 (a)
MDGA1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mdga1 35
  • 89.83 (n)
  • 96.09 (a)
Mdga1 16
Mdga1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MDGA1 35
  • 99.72 (n)
  • 99.9 (a)
MDGA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdga1 35
  • 89.38 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia MDGA1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDGA1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MDGA1 35
  • 74.53 (n)
  • 79.24 (a)
MDGA1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MDGA1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13549 35
zebrafish
(Danio rerio)
Actinopterygii LOC569180 35
  • 65.07 (n)
  • 62.63 (a)
MDGA1 36
  • 61 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for MDGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDGA1 Gene

ENSEMBL:
Gene Tree for MDGA1 (if available)
TreeFam:
Gene Tree for MDGA1 (if available)

Paralogs for MDGA1 Gene

Paralogs for MDGA1 Gene

(8) SIMAP similar genes for MDGA1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MDGA1: view

Variants for MDGA1 Gene

Sequence variations from dbSNP and Humsavar for MDGA1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs708020 -- 37,649,793(+) TCATC(C/T)TGTTA intron-variant, utr-variant-3-prime
rs708021 -- 37,649,753(+) AACTC(C/T)TAGAA intron-variant, downstream-variant-500B
rs708022 -- 37,649,743(+) AGTGC(A/C)TTAAA intron-variant, downstream-variant-500B
rs708023 -- 37,636,559(-) TCCTA(G/T)CCTCA utr-variant-3-prime
rs761413 -- 37,664,458(+) CCTCC(C/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDGA1 Gene

Variant ID Type Subtype PubMed ID
esv2752124 CNV Gain 17911159
esv2731934 CNV Deletion 23290073
esv2667581 CNV Deletion 23128226
esv27953 CNV Loss 19812545

Variation tolerance for MDGA1 Gene

Residual Variation Intolerance Score: 18.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MDGA1 Gene

HapMap Linkage Disequilibrium report
MDGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDGA1 Gene

Disorders for MDGA1 Gene

Relevant External Links for MDGA1

Genetic Association Database (GAD)
MDGA1
Human Genome Epidemiology (HuGE) Navigator
MDGA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MDGA1
genes like me logo Genes that share disorders with MDGA1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MDGA1 Gene

Publications for MDGA1 Gene

  1. Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts. (PMID: 15922729) Diaz-Lopez A. … De Juan C. (Exp. Cell Res. 2005) 2 67
  2. Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization. (PMID: 15019943) Litwack E.D. … O'Leary D.D. (Mol. Cell. Neurosci. 2004) 2 67
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 67
  4. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. (PMID: 23248271) Lee K. … Ko J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67
  5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 67

Products for MDGA1 Gene

Sources for MDGA1 Gene

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