Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MDGA1 Gene

Aliases for MDGA1 Gene

  • MAM Domain Containing Glycosylphosphatidylinositol Anchor 1 2 3 5
  • Glycosylphosphatidylinositol-MAM 3 4
  • MAM Domain-Containing Protein 3 3 4
  • GPI And MAM Protein 3 4
  • MAMDC3 3 4
  • GPIM 3 4
  • Glycosyl-Phosphatidyl-Inositol-MAM 3

External Ids for MDGA1 Gene

Previous GeneCards Identifiers for MDGA1 Gene

  • GC06U990326
  • GC06M037596
  • GC06M037647
  • GC06M037708
  • GC06M037319

Summaries for MDGA1 Gene

GeneCards Summary for MDGA1 Gene

MDGA1 (MAM Domain Containing Glycosylphosphatidylinositol Anchor 1) is a Protein Coding gene. An important paralog of this gene is MAMDC2.

UniProtKB/Swiss-Prot for MDGA1 Gene

  • Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDGA1 Gene

Genomics for MDGA1 Gene

Regulatory Elements for MDGA1 Gene

Enhancers for MDGA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MDGA1 on UCSC Golden Path with GeneCards custom track

Promoters for MDGA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MDGA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MDGA1 Gene

37,630,679 bp from pter
37,699,306 bp from pter
68,628 bases
Minus strand

Genomic View for MDGA1 Gene

Genes around MDGA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDGA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDGA1 Gene

Proteins for MDGA1 Gene

  • Protein details for MDGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAM domain-containing glycosylphosphatidylinositol anchor protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NHG0
    • Q8NBE3

    Protein attributes for MDGA1 Gene

    955 amino acids
    Molecular mass:
    105790 Da
    Quaternary structure:
    • Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its Ig-like domains with proteins in differentiating muscle (By similarity). Interacts (through the Ig-like domains) with NLGN2.
    • Sequence=BAC03502.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MDGA1 Gene


neXtProt entry for MDGA1 Gene

Proteomics data for MDGA1 Gene at MOPED

Post-translational modifications for MDGA1 Gene

  • Glycosylation at Asn 42, Asn 90, Asn 235, Asn 247, Asn 257, Asn 307, Asn 331, Asn 432, Asn 655, Asn 747, and Asn 826
  • Modification sites at PhosphoSitePlus

Other Protein References for MDGA1 Gene

Antibody Products

  • Abcam antibodies for MDGA1

No data available for DME Specific Peptides for MDGA1 Gene

Domains & Families for MDGA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibronectin type-III domain.
  • Contains 1 fibronectin type-III domain.
  • Contains 6 Ig-like (immunoglobulin-like) domains.
  • Contains 1 MAM domain.
genes like me logo Genes that share domains with MDGA1: view

Function for MDGA1 Gene

Molecular function for MDGA1 Gene

UniProtKB/Swiss-Prot Function:
Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.
genes like me logo Genes that share phenotypes with MDGA1: view

Animal Models for MDGA1 Gene

MGI Knock Outs for MDGA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MDGA1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDGA1 Gene

Localization for MDGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDGA1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Associated with lipid rafts.

Subcellular locations from

Jensen Localization Image for MDGA1 Gene COMPARTMENTS Subcellular localization image for MDGA1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MDGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0046658 anchored component of plasma membrane ISS 15019943
genes like me logo Genes that share ontologies with MDGA1: view

Pathways & Interactions for MDGA1 Gene

SuperPathways for MDGA1 Gene

No Data Available

Interacting Proteins for MDGA1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000402584 for MDGA1 Gene via STRING

Gene Ontology (GO) - Biological Process for MDGA1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MDGA1 Gene

Drugs & Compounds for MDGA1 Gene

No Compound Related Data Available

Transcripts for MDGA1 Gene

Unigene Clusters for MDGA1 Gene

MAM domain containing glycosylphosphatidylinositol anchor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDGA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP2: - -
SP3: -
SP6: - -
SP7: -
SP8: -
SP11: -
SP12: -

ExUns: 18b · 18c ^ 19 ^ 20a · 20b · 20c

Relevant External Links for MDGA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MDGA1 Gene

mRNA expression in normal human tissues for MDGA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MDGA1 Gene

This gene is overexpressed in Brain - Cerebellum (x19.2) and Brain - Cerebellar Hemisphere (x16.8).

Protein differential expression in normal tissues from HIPED for MDGA1 Gene

This gene is overexpressed in Fetal Brain (56.4) and Retina (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MDGA1 Gene

SOURCE GeneReport for Unigene cluster for MDGA1 Gene Hs.437993

mRNA Expression by UniProt/SwissProt for MDGA1 Gene

Tissue specificity: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.
genes like me logo Genes that share expression patterns with MDGA1: view

Protein tissue co-expression partners for MDGA1 Gene

Primer Products

Orthologs for MDGA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDGA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MDGA1 35
  • 92.36 (n)
  • 97.28 (a)
MDGA1 36
  • 97 (a)
(Canis familiaris)
Mammalia MDGA1 35
  • 92.42 (n)
  • 97.27 (a)
MDGA1 36
  • 98 (a)
(Mus musculus)
Mammalia Mdga1 35
  • 89.83 (n)
  • 96.09 (a)
Mdga1 16
Mdga1 36
  • 96 (a)
(Pan troglodytes)
Mammalia MDGA1 35
  • 99.72 (n)
  • 99.9 (a)
MDGA1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mdga1 35
  • 89.38 (n)
  • 95.33 (a)
(Monodelphis domestica)
Mammalia MDGA1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia MDGA1 36
  • 63 (a)
(Gallus gallus)
Aves MDGA1 35
  • 74.53 (n)
  • 79.24 (a)
MDGA1 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MDGA1 36
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13549 35
(Danio rerio)
Actinopterygii LOC569180 35
  • 65.07 (n)
  • 62.63 (a)
MDGA1 36
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for MDGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDGA1 Gene

Gene Tree for MDGA1 (if available)
Gene Tree for MDGA1 (if available)

Paralogs for MDGA1 Gene

Paralogs for MDGA1 Gene

(8) SIMAP similar genes for MDGA1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MDGA1: view

Variants for MDGA1 Gene

Sequence variations from dbSNP and Humsavar for MDGA1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10947690 - 37,663,992(+) TTACA(A/G/T)GGCAC nc-transcript-variant, reference, missense
rs4992764 -- 37,671,411(+) AATAC(A/G)AAACT intron-variant
rs5875590 -- 37,657,159(+) ACTTT(-/A)AAAAA intron-variant
rs5875591 -- 37,687,980(+) CTCTT(-/G)GCCTG intron-variant
rs6149535 -- 37,662,643(+) AAAAA(A/G)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDGA1 Gene

Variant ID Type Subtype PubMed ID
esv2752124 CNV Gain 17911159
esv2731934 CNV Deletion 23290073
esv2667581 CNV Deletion 23128226
esv27953 CNV Loss 19812545

Variation tolerance for MDGA1 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MDGA1 Gene

Disorders for MDGA1 Gene

Relevant External Links for MDGA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MDGA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MDGA1 Gene

Publications for MDGA1 Gene

  1. Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts. (PMID: 15922729) Diaz-Lopez A. … De Juan C. (Exp. Cell Res. 2005) 2 3 4 67
  2. Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization. (PMID: 15019943) Litwack E.D. … O'Leary D.D. (Mol. Cell. Neurosci. 2004) 2 3
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3

Products for MDGA1 Gene

Sources for MDGA1 Gene