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MDGA1 Gene

protein-coding   GIFtS: 50
GCID: GC06M037598

MAM Domain Containing Glycosylphosphatidylinositol Anchor...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAM Domain Containing Glycosylphosphatidylinositol Anchor 11 2     glycosyl-phosphatidyl-inositol-MAM2
GPIM2 3 5     glycosylphosphatidylinositol-MAM2
MAMDC32 3     MAM Domain-Containing Glycosylphosphatidylinositol Anchor Protein 12
GPI And MAM Protein2 3     Glycosylphosphatidylinositol-MAM3
MAM Domain-Containing Protein 32 3     

External Ids:    HGNC: 192671   Entrez Gene: 2667272   Ensembl: ENSG000001121397   OMIM: 6096265   UniProtKB: Q8NFP43   

Export aliases for MDGA1 gene to outside databases

Previous GC identifers: GC06U990326 GC06M037596 GC06M037647 GC06M037708 GC06M037319


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MDGA1 Gene:
MDGA1 (MAM domain containing glycosylphosphatidylinositol anchor 1) is a protein-coding gene. An important paralog of this gene is MAMDC4.

UniProtKB/Swiss-Prot: MDGA1_HUMAN, Q8NFP4
Function: Required for radial migration of cortical neurons in the superficial layer of the neocortex (By
similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the
activity of NLGN2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MDGA1 gene promoter:
         E2F-4   E2F-3a   USF1   E2F-5   Elk-1   MAZR   AP-4   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMDGA1 promoter sequence
   Search Chromatin IP Primers for MDGA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MDGA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21

MDGA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDGA1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M037598:  view genomic region     (about GC identifiers)

Start:
37,600,284 bp from pter      End:
37,667,082 bp from pter
Size:
66,799 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MDGA1_HUMAN, Q8NFP4 (See protein sequence)
Recommended Name: MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor  
Size: 955 amino acids; 105790 Da
Subunit: Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its
Ig-like domains with proteins in differentiating muscle (By similarity). Interacts (through the Ig-like domains)
with NLGN2
Sequence caution: Sequence=BAC03502.1; Type=Erroneous initiation;
Secondary accessions: A6NHG0 Q8NBE3
Alternative splicing: 2 isoforms:  Q8NFP4-1   Q8NFP4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MDGA1: NX_Q8NFP4

Explore proteomics data for MDGA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn90, Asn235, Asn247, Asn257, Asn307, Asn331, Asn432, Asn655, Asn747,
                                 Asn826

  • See MDGA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_705691.1  
    ENSEMBL proteins: 
     ENSP00000402584   ENSP00000422042   ENSP00000393330   ENSP00000425911   ENSP00000421510  
     ENSP00000427645   ENSP00000297153  

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    Cloud-Clone Corp. Proteins for MDGA1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFP4

    ProtoNet protein and cluster: Q8NFP4

    3 Blocks protein domains:
    IPB000998 MAM domain signature
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: MDGA1_HUMAN, Q8NFP4
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 6 Ig-like (immunoglobulin-like) domains
    Similarity: Contains 1 MAM domain


    Find genes that share domains with MDGA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDGA1_HUMAN, Q8NFP4
    Function: Required for radial migration of cortical neurons in the superficial layer of the neocortex (By
    similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the
    activity of NLGN2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with MDGA1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mdga1):
     cellular  nervous system 

    Find genes that share phenotypes with MDGA1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MDGA1
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    hsa-mir-210-3p (MIRT003161)

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    Selected qRT-PCR Assays for microRNAs that regulate MDGA1 (see all 86):
    hsa-miR-3607-3p hsa-miR-200a hsa-miR-134 hsa-miR-128 hsa-miR-3138 hsa-miR-877* hsa-miR-629* hsa-miR-509-3-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MDGA1_HUMAN, Q8NFP4: Cell membrane; Lipid-anchor, GPI-anchor. Note=Associated with lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0016020membrane ----
    GO:0046658anchored component of plasma membrane ISS15019943

    Find genes that share ontologies with MDGA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MDGA1
    Interactions:

        Search GeneGlobe Interaction Network for MDGA1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MDGA1 (ENSP000002971534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAPBPLENSP000002665564STRING: ENSP00000266556
    SIRPAENSP000003483074STRING: ENSP00000348307
    PVRENSP000004020604STRING: ENSP00000402060
    --ENSP000003687484STRING: ENSP00000368748
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration ISS--
    GO:0007420brain development ISS15019943
    GO:0021527spinal cord association neuron differentiation ISS15019943
    GO:0021799cerebral cortex radially oriented cell migration IEA--

    Find genes that share ontologies with MDGA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MDGA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MDGA1 gene: 
    NM_153487.3  

    Unigene Cluster for MDGA1:

    MAM domain containing glycosylphosphatidylinositol anchor 1
    Hs.437993  [show with all ESTs]
    Unigene Representative Sequence: AF478693
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434837(uc003onu.1 uc003onv.1) ENST00000373401 ENST00000505425
    ENST00000503419 ENST00000418178 ENST00000502298 ENST00000510077 ENST00000478143
    ENST00000515437 ENST00000508399 ENST00000297153
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MDGA1 (see all 86):
    hsa-miR-3607-3p hsa-miR-200a hsa-miR-134 hsa-miR-128 hsa-miR-3138 hsa-miR-877* hsa-miR-629* hsa-miR-509-3-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    OriGene ORF clones in mouse, rat for MDGA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MDGA1 (NM_153487)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDGA1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MDGA1
      QuantiTect SYBR Green Assays in human, mouse, rat MDGA1
      QuantiFast Probe-based Assays in human, mouse, rat MDGA1

    Additional mRNA sequence: 

    AF478693.1 AK055376.1 AK091650.1 AK092308.1 AK126965.1 BX647180.1 BX647253.1 

    7 DOTS entries:

    DT.40113406  DT.101973692  DT.100022137  DT.100755333  DT.100022135  DT.204494  DT.40313562 

    Selected AceView cDNA sequences (see all 81):

    AX746808 AI827393 AW593235 AI813394 AW014039 R88808 AK091149 AA481631 
    BP344579 CK300811 AA325266 AW003899 BX101256 NM_153487 AF478693 AA689430 
    BF724152 BM673820 AK091650 AI971763 AK092308 BG031503 BX647180 CB153056 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MDGA1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                  -     -   
    SP3:        -                                                                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18b · 18c ^ 19 ^ 20a · 20b · 20c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for MDGA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MDGA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGACCACC
    MDGA1 Expression
    About this image


    MDGA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
    MDGA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MDGA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437993

    UniProtKB/Swiss-Prot: MDGA1_HUMAN, Q8NFP4
    Tissue specificity: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor
    tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDGA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MDGA1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mdga11 , 5 MAM domain containing glycosylphosphatidylinositol more1, 5 89.83(n)1
    96.09(a)1
      17 (15.54 cM)5
    747621  NM_001081160.11  NP_001074629.11 
     298279565 
    chicken
    (Gallus gallus)
    Aves MDGA11 MAM domain containing glycosylphosphatidylinositol more 74.53(n)
    79.24(a)
      421431  NM_001044647.1  NP_001038112.1 
    lizard
    (Anolis carolinensis)
    Reptilia MDGA16
    MAM domain containing glycosylphosphatidylinositol...
    76(a)
    1 ↔ 1
    1(228758965-229100355)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135492 Xenopus laevis transcribed sequence with weak similarity more 72.51(n)    BJ057835.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5691801 MAM domain-containing glycosylphosphatidylinositol more 65.07(n)
    62.63(a)
      569180  XM_692548.6  XP_697640.6 


    ENSEMBL Gene Tree for MDGA1 (if available)
    TreeFam Gene Tree for MDGA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MDGA1 gene
    MAMDC42  MDGA22  MALRD12  ENSG000002727812  MAMDC22  
    8 SIMAP similar genes for MDGA1 using alignment to 7 protein entries:     MDGA1_HUMAN (see all proteins):
    MDGA2    NRP1    DIET1    L1CAM    MUSK    DCC
    NFASC    LSAMP

    Find genes that share paralogs with MDGA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MDGA1 (see all 1613)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930385341,2
    --37599786(+) TCCTTA/GAGCCT 1 -- ds50010--------
    rs1857809301,2
    --37599853(+) CTCTCC/TCAATC 1 -- ds50010--------
    rs1872204551,2
    --37599947(+) CCTCTC/TCATAC 1 -- ds50010--------
    rs69267351,2
    C,F,A,H--37599962(+) TTTCAT/CAGCAC 1 -- ds500119Minor allele frequency- C:0.25NS EA WA NA 2756
    rs773116661,2
    F--37599985(+) CCAGCC/TCTCAC 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1112448461,2
    C,F--37599995(+) CTGTAC/TACATC 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1455934551,2
    C--37600107(+) AATGC-/ACGAGG
            
    ACACA
    1 -- cds10--------
    rs611510791,2
    C--37600109(+) TGCAC-/GAGGAC
            
    ACAAG
    1 -- cds10--------
    rs69270741,2
    C,F,A,H--37600120(+) TTCACT/CGGGAG 1 -- ds50017Minor allele frequency- C:0.24NS EA WA NA 778
    rs752896151,2
    F--37600172(+) GGATCC/TCTGTC 1 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for MDGA1 (37600284 - 37667082 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MDGA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667581CNV Deletion23128226
    esv2731934CNV Deletion23290073
    esv27953CNV Loss19812545
    esv2752124CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MDGA1
    DNA2.0 Custom Variant and Variant Library Synthesis for MDGA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609626    OMIM disorders: --


    Find genes that share disorders with MDGA1           About GenesLikeMe

    Genetic Association Database (GAD): MDGA1
    Human Genome Epidemiology (HuGE) Navigator: MDGA1 (4 documents)

    Export disorders for MDGA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MDGA1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with MDGA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts. (PubMed id 15922729)1, 2, 3 Diaz-Lopez A....De Juan C. (Exp. Cell Res. 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. WITHDRAWN: Common polymorphisms in the MDGA1 gene are associated with bipolar disorder and schizophrenia in the Chinese Han population. (PubMed id 20036297)1, 4 Li J....Shi Y. (amp 2009)
    4. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1, 4 KAohler A.K....Andreassen O.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    6. Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization. (PubMed id 15019943)1, 3 Litwack E.D....O'Leary D.D. (Mol. Cell. Neurosci. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors. (PubMed id 12082541)1, 2 De Juan C.... Benito M. (Oncogene 2002)
    9. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. (PubMed id 23248271)2 Lee K....Ko J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 266727 HGNC: 19267 AceView: MDGA1 Ensembl:ENSG00000112139 euGenes: HUgn266727
    ECgene: MDGA1 H-InvDB: MDGA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MDGA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MDGA1 gene:
    Search GeneIP for patents involving MDGA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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