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Aliases for MDFIC Gene

Aliases for MDFIC Gene

  • MyoD Family Inhibitor Domain Containing 2 3
  • HIC 3 4 6
  • I-Mfa Domain-Containing Protein 3 4
  • MyoD Family Inhibitor Domain-Containing Protein 3

External Ids for MDFIC Gene

Previous GeneCards Identifiers for MDFIC Gene

  • GC07P114157
  • GC07P114349
  • GC07P114562
  • GC07P108926

Summaries for MDFIC Gene

Entrez Gene Summary for MDFIC Gene

  • This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for MDFIC Gene

MDFIC (MyoD Family Inhibitor Domain Containing) is a Protein Coding gene. Diseases associated with MDFIC include doid:4019. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include transcription factor binding and Tat protein binding. An important paralog of this gene is MDFI.

UniProtKB/Swiss-Prot for MDFIC Gene

  • Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDFIC Gene

Genomics for MDFIC Gene

Regulatory Elements for MDFIC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MDFIC Gene

Start:
114,922,154 bp from pter
End:
115,019,916 bp from pter
Size:
97,763 bases
Orientation:
Plus strand

Genomic View for MDFIC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MDFIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDFIC Gene

Proteins for MDFIC Gene

  • Protein details for MDFIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1T7-MDFIC_HUMAN
    Recommended name:
    MyoD family inhibitor domain-containing protein
    Protein Accession:
    Q9P1T7
    Secondary Accessions:
    • Q9P1T6

    Protein attributes for MDFIC Gene

    Size:
    246 amino acids
    Molecular mass:
    25788 Da
    Quaternary structure:
    • Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with ZIC2 (By similarity). The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1.

    Alternative splice isoforms for MDFIC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDFIC Gene

Proteomics data for MDFIC Gene at MOPED

Post-translational modifications for MDFIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MDFIC Gene

Domains for MDFIC Gene

Protein Domains for MDFIC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MDFIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1T7

UniProtKB/Swiss-Prot:

MDFIC_HUMAN :
  • Q9P1T7
Domain:
  • The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity). The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.
Family:
  • Belongs to the MDFI family.
genes like me logo Genes that share domains with MDFIC: view

No data available for Gene Families for MDFIC Gene

Function for MDFIC Gene

Molecular function for MDFIC Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.

Gene Ontology (GO) - Molecular Function for MDFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12192039
GO:0008134 transcription factor binding IPI 12192039
GO:0030332 cyclin binding IPI 12944466
GO:0030515 snoRNA binding --
GO:0030957 Tat protein binding IDA 12944466
genes like me logo Genes that share ontologies with MDFIC: view

Animal Model Products

CRISPR Products

miRNA for MDFIC Gene

miRTarBase miRNAs that target MDFIC

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MDFIC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MDFIC Gene

Localization for MDFIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDFIC Gene

Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.
Isoform 2: Cytoplasm. Note=Weak expression in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MDFIC Gene COMPARTMENTS Subcellular localization image for MDFIC gene
Compartment Confidence
nucleus 5
golgi apparatus 4
extracellular 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MDFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10671520
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 10671520
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with MDFIC: view

Pathways for MDFIC Gene

genes like me logo Genes that share pathways with MDFIC: view

Pathways by source for MDFIC Gene

Gene Ontology (GO) - Biological Process for MDFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis --
GO:0006351 transcription, DNA-templated IEA --
GO:0007257 activation of JUN kinase activity IDA 12192039
GO:0016032 viral process IEA --
GO:0030111 regulation of Wnt signaling pathway IDA 12192039
genes like me logo Genes that share ontologies with MDFIC: view

Transcripts for MDFIC Gene

Unigene Clusters for MDFIC Gene

MyoD family inhibitor domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MDFIC

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MDFIC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MDFIC Gene

No ASD Table

Relevant External Links for MDFIC Gene

GeneLoc Exon Structure for
MDFIC
ECgene alternative splicing isoforms for
MDFIC

Expression for MDFIC Gene

mRNA expression in normal human tissues for MDFIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MDFIC Gene

SOURCE GeneReport for Unigene cluster for MDFIC Gene Hs.741413

mRNA Expression by UniProt/SwissProt for MDFIC Gene

Q9P1T7-MDFIC_HUMAN
Tissue specificity: Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.
genes like me logo Genes that share expressions with MDFIC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MDFIC Gene

Orthologs for MDFIC Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDFIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MDFIC 35
  • 99.19 (n)
  • 99.59 (a)
MDFIC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MDFIC 35
  • 90.08 (n)
  • 90.5 (a)
MDFIC 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC612042 35
  • 90.26 (n)
  • 86.83 (a)
MDFIC 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mdfic 35
  • 83.88 (n)
  • 81.71 (a)
Mdfic 16
Mdfic 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MDFIC 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDFIC 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdfic 35
  • 83.33 (n)
  • 80.08 (a)
chicken
(Gallus gallus)
Aves MDFIC 35
  • 76.82 (n)
  • 73.66 (a)
MDFIC 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MDFIC 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398213 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mdfic 35
  • 71.14 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii MDFIC (1 of 2) 36
  • 51 (a)
OneToMany
MDFIC (2 of 2) 36
  • 64 (a)
OneToMany
si:ch73-156e19.1 35
  • 68.95 (n)
  • 67.43 (a)
Species with no ortholog for MDFIC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDFIC Gene

ENSEMBL:
Gene Tree for MDFIC (if available)
TreeFam:
Gene Tree for MDFIC (if available)

Paralogs for MDFIC Gene

Paralogs for MDFIC Gene

Selected SIMAP similar genes for MDFIC Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MDFIC: view

Variants for MDFIC Gene

Sequence variations from dbSNP and Humsavar for MDFIC Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs767903 -- 114,933,127(-) ATACA(C/G)AGTTA intron-variant
rs1055521 -- 115,018,166(+) TCTTT(A/G)TACTA utr-variant-3-prime
rs1713165 -- 114,992,760(-) ttcaa(C/T)aaaat intron-variant
rs2290076 -- 114,942,107(-) GTATT(C/T)ACTGA intron-variant
rs2375541 -- 114,993,161(-) accat(C/G)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDFIC Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv526154 CNV Loss 19592680
nsv819577 CNV Loss 19587683

Relevant External Links for MDFIC Gene

HapMap Linkage Disequilibrium report
MDFIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDFIC Gene

Disorders for MDFIC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MDFIC Gene including...

Search for MDFIC Gene in MalaCards »

(2) University of Copenhagen DISEASES for MDFIC Gene

(2) Novoseek inferred disease relationships for MDFIC Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 51.2 2
immunodeficiency 28.9 1

Relevant External Links for MDFIC

Genetic Association Database (GAD)
MDFIC
Human Genome Epidemiology (HuGE) Navigator
MDFIC
genes like me logo Genes that share disorders with MDFIC: view

No data available for UniProtKB/Swiss-Prot for MDFIC Gene

Publications for MDFIC Gene

  1. Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV- 1 expression. (PMID: 10671520) Thebault S. … Mesnard J.-M. (J. Biol. Chem. 2000) 2 3 4 23
  2. Sequence requirement for the nucleolar localization of human I-mfa domain-containing protein (HIC p40). (PMID: 11139147) Thebault S. … Mesnard J.-M. (Eur. J. Cell Biol. 2000) 3 4 23
  3. I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. (PMID: 12192039) Kusano S. … Raab-Traub N. (Mol. Cell. Biol. 2002) 3 4 23
  4. Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. (PMID: 16260749) Gautier V.W. … Hall W.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  5. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PMID: 12944466) Young T.M. … Mathews M.B. (Mol. Cell. Biol. 2003) 3 4 23

Products for MDFIC Gene

Sources for MDFIC Gene

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