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MDFIC Gene

protein-coding   GIFtS: 51
GCID: GC07P114562

MyoD Family Inhibitor Domain Containing

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MyoD Family Inhibitor Domain Containing1 2
I-Mfa Domain-Containing Protein2 3
HIC2 5
MyoD Family Inhibitor Domain-Containing Protein2
hIC3

External Ids:    HGNC: 288701   Entrez Gene: 299692   Ensembl: ENSG000001352727   OMIM: 6145115   UniProtKB: Q9P1T73   

Export aliases for MDFIC gene to outside databases

Previous GC identifers: GC07P114157 GC07P114349 GC07P108926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MDFIC Gene:
This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain,
which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation
from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms,
p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm,
whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is
attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Oct 2009)

GeneCards Summary for MDFIC Gene:
MDFIC (MyoD family inhibitor domain containing) is a protein-coding gene. Diseases associated with MDFIC include doid:4019, and apraxia. GO annotations related to this gene include Tat protein binding and transcription factor binding. An important paralog of this gene is MDFI.

UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7
Function: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family
proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the
expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human
immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear
import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human
T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of
free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MDFIC gene promoter:
         c-Fos   AP-1   COMP1   ATF-2   Nkx2-5   c-Jun   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMDFIC promoter sequence
   Search Chromatin IP Primers for MDFIC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MDFIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1-q31.2   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.1-q31.2

MDFIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDFIC gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P114562:  view genomic region     (about GC identifiers)

Start:
114,562,209 bp from pter      End:
114,659,970 bp from pter
Size:
97,762 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 113,957,476-114,055,279     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7 (See protein sequence)
Recommended Name: MyoD family inhibitor domain-containing protein  
Size: 246 amino acids; 25788 Da
Subunit: Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts
with ZIC2 (By similarity). The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of
CCNT1/cyclin-T and weakly with LEF1
Secondary accessions: Q9P1T6
Alternative initiation: 2 isoforms:  Q9P1T7-2   Q9P1T7-1   (Minor isoform. Initiates from a GTG codon. Contains a Nucleolar localization signal at positions 45-63)

Explore the universe of human proteins at neXtProt for MDFIC: NX_Q9P1T7

Explore proteomics data for MDFIC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MDFIC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001159817.1  NP_001159818.3  NP_951038.1  

    ENSEMBL proteins: 
     ENSP00000377126   ENSP00000257724   ENSP00000412153   ENSP00000401623   ENSP00000416668  
     ENSP00000392098   ENSP00000418337  

    MDFIC Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MDFIC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026134 MDFI/MDFIC

    Graphical View of Domain Structure for InterPro Entry Q9P1T7

    ProtoNet protein and cluster: Q9P1T7

    UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7
    Domain: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity).
    The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm
    Similarity: Belongs to the MDFI family


    MDFIC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDFIC_HUMAN, Q9P1T7
    Function: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family
    proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the
    expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human
    immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear
    import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human
    T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of
    free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12192039
    GO:0008134transcription factor binding IPI12192039
    GO:0030332cyclin binding IPI12944466
    GO:0030515snoRNA binding ----
    GO:0030957Tat protein binding IDA12944466
         
    MDFIC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MDFIC
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MDFIC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MDFIC

    miRNA
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    miRTarBase miRNAs that target MDFIC:
    hsa-mir-132-3p (MIRT021846), hsa-mir-124-3p (MIRT002667), hsa-mir-221-3p (MIRT046893)

    Block miRNA regulation of human, mouse, rat MDFIC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MDFIC (see all 35):
    hsa-miR-607 hsa-miR-4328 hsa-miR-24-1* hsa-miR-301a hsa-miR-766 hsa-miR-10b* hsa-miR-374c hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidMDFIC 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MDFIC
    Predesigned siRNA for gene silencing in human, mouse, rat MDFIC

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MDFIC (see all 15)
    OriGene ORF clones in mouse, rat for MDFIC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MDFIC (NM_001166346)
    Sino Biological Human cDNA Clone for MDFIC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDFIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDFIC

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MDFIC 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDFIC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MDFIC_HUMAN, Q9P1T7: Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm
    MDFIC_HUMAN, Q9P1T7: Isoform 2: Cytoplasm. Note=Weak expression in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    extracellular3
    cytosol1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA10671520
    GO:0005794Golgi apparatus IDA--
    GO:0072588box H/ACA RNP complex ----

    MDFIC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MDFIC About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 BioSystems Pathway for MDFIC
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MDFIC
    Interactions:

        GeneGlobe Interaction Network for MDFIC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MDFIC (Q9P1T73 ENSP000002577244) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNT1O605633, ENSP000002619004I2D: score=1 STRING: ENSP00000261900
    TATP177353, ENSP000003482344I2D: score=1 STRING: ENSP00000348234
    CDK9P507503, ENSP000003623614I2D: score=1 STRING: ENSP00000362361
    MYF5ENSP000002286444STRING: ENSP00000228644
    MYOGENSP000002416514STRING: ENSP00000241651
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001522pseudouridine synthesis ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0007257activation of JUN kinase activity IDA12192039
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    MDFIC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MDFIC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MDFIC gene (3 alternative transcripts): 
    NM_001166345.1  NM_001166346.1  NM_199072.4  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393486(uc022akf.1 uc003vhf.3) ENST00000257724 ENST00000448022
    ENST00000423503(uc003vhg.3) ENST00000431629 ENST00000427207 ENST00000498196

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat MDFIC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MDFIC (see all 35):
    hsa-miR-607 hsa-miR-4328 hsa-miR-24-1* hsa-miR-301a hsa-miR-766 hsa-miR-10b* hsa-miR-374c hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidMDFIC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MDFIC
    Predesigned siRNA for gene silencing in human, mouse, rat MDFIC
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MDFIC (NM_001166346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDFIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDFIC
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MDFIC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MDFIC
      QuantiTect SYBR Green Assays in human, mouse, rat MDFIC
      QuantiFast Probe-based Assays in human, mouse, rat MDFIC

    Selected AceView cDNA sequences (see all 99):

    CA421173 BX479785 CA748571 BI861905 NM_199072 AW778759 BQ434566 AL701945 
    BM453859 BG030431 AW472996 AA828329 AI668639 AF054589 BC040713 AV703021 
    CD365679 CB529151 AW291802 AI935612 BU742436 AA312951 AI734211 BM091515 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MDFIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAAGTGCT
    MDFIC Expression
    About this image


    MDFIC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
    MDFIC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MDFIC Protein Expression

    UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7
    Tissue specificity: Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as
    prostate, uterus and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MDFIC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MDFIC gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mdfic1 , 5 MyoD family inhibitor domain containing1, 5 83.88(n)1
    81.71(a)1
      6 (6.85 cM)5
    165431  NM_175088.51  NP_780297.31 
     157206615 
    chicken
    (Gallus gallus)
    Aves MDFIC1 MyoD family inhibitor domain containing 76.82(n)
    73.66(a)
      417774  XM_416018.4  XP_416018.1 
    lizard
    (Anolis carolinensis)
    Reptilia MDFIC6
    MyoD family inhibitor domain containing
    59(a)
    1 ↔ 1
    5(59670379-59719441)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982132 I-mfa domain protein XIC 75.88(n)    AY017419.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-156e19.11 si:ch73-156e19.1 68.95(n)
    67.43(a)
      100536917  XM_003198606.2  XP_003198654.1 


    ENSEMBL Gene Tree for MDFIC (if available)
    TreeFam Gene Tree for MDFIC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MDFIC gene
    MDFI2  
    1 SIMAP similar gene for MDFIC using alignment to 6 protein entries:     MDFIC_HUMAN (see all proteins):
    MDFI

    MDFIC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MDFIC (see all 1952)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006843801,2
    C--108954288(+) AACCCC/TAAATG 2 -- int10--------
    rs732147141,2
    C,F--108981361(+) TTTTTT/CTTTTC 2 -- int11Minor allele frequency- C:0.06NA 120
    rs769516201,2
    C--108997476(-) TCCAGA/GACCAG 2 -- int10--------
    rs40142361,2
    C--108997717(-) tagacA/Gcaata 2 -- int11Minor allele frequency- G:0.00NA 2
    rs343948351,2
    C--109004275(+) GGGTC-/ACAATG 2 -- int11Minor allele frequency- A:0.50NA 2
    rs342418281,2
    C--109017841(+) GCTGG-/AACGAG 2 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs2014251671,2
    C--109017841(+) GCTGGA/GACGAG 2 -- int10--------
    rs352625081,2
    C--113958100(+) CGCTGTT/-TAACA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs601254411,2
    C--113986600(+) ATCTC-/TGGTTC 2 -- int11Minor allele frequency- T:0.00NA 2
    rs1438507101,2
    C--113991709(+) CACAC-/ATATATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for MDFIC (114562209 - 114659970 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MDFIC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526154CNV Loss19592680
    nsv819577CNV Loss19587683
    nsv7405OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MDFIC
    DNA2.0 Custom Variant and Variant Library Synthesis for MDFIC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614511    OMIM disorders: --

    7 diseases for MDFIC:    
    About MalaCards
    doid:4019    apraxia    t-cell leukemia    hiv-1
    obesity    leukemia    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for MDFIC:
    Apraxia     DOID:4019

    MDFIC for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MDFIC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 51.2 2 10671520 (2)
    immunodeficiency 28.9 1 10671520 (1)

    Genetic Association Database (GAD): MDFIC
    Human Genome Epidemiology (HuGE) Navigator: MDFIC (1 document)

    Export disorders for MDFIC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MDFIC gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MDFIC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV- 1 expression. (PubMed id 10671520)1, 2, 3, 9 Thebault S.... Mesnard J.-M. (J. Biol. Chem. 2000)
    2. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PubMed id 12944466)1, 2, 9 Young T.M.... Mathews M.B. (Mol. Cell. Biol. 2003)
    3. I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. (PubMed id 12192039)1, 2, 9 Kusano S. and Raab-Traub N. (Mol. Cell. Biol. 2002)
    4. Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. (PubMed id 16260749)1, 2, 9 Gautier V.W.... Hall W.W. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    5. Sequence requirement for the nucleolar localization of human I-mfa domain-containing protein (HIC p40). (PubMed id 11139147)1, 2, 9 Thebault S.... Mesnard J.-M. (Eur. J. Cell Biol. 2000)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Expression profile and differential regulation of the Human I-mfa domain-Containing protein (HIC) gene in immune cells. (PubMed id 19428567)1, 9 Gu L....Gautier V.W. (Immunol. Lett. 2009)
    8. The complex regulation of HIC (Human I-mfa domain containing protein) expression. (PubMed id 19582149)1, 9 Reiss-Sklan E....Naveh-Many T. (PLoS ONE 2009)
    9. The 3'UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells. (PubMed id 19041912)1, 9 Liu J....Chao S.H. (J. Biotechnol. 2009)
    10. Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription. (PubMed id 17289077)1, 9 Wang Q....Pe'ery T. (J. Mol. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29969 HGNC: 28870 AceView: HIC Ensembl:ENSG00000135272 euGenes: HUgn29969
    ECgene: MDFIC H-InvDB: MDFIC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MDFIC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MDFIC gene:
    Search GeneIP for patents involving MDFIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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