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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MDFIC Gene

protein-coding   GIFtS: 51
GCID: GC07P114562

MyoD family inhibitor domain containing
 Explore 5 diseases affiliated with
MDFIC via
MalaCards
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 Human Malady Compendium 
Biological research products
for MDFIC    

Aliases
for MDFIC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MyoD Family Inhibitor Domain Containing1 2
HIC1 2
I-Mfa Domain-Containing Protein2 3
MyoD Family Inhibitor Domain-Containing Protein2
HIC1 2

External Ids:    HGNC: 288701   Entrez Gene: 299692   Ensembl: ENSG000001352727   OMIM: 6145115   UniProtKB: Q9P1T73   

Export aliases for MDFIC gene to outside databases

Previous GC identifers: GC07P114157 GC07P114349 GC07P108926


Summaries
for MDFIC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MDFIC:
This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain,
which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an
upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32,
respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is
targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the
cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Oct 2009)

UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7
Function: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family
proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the
expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human
immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import,
probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell
leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free
beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways




Genomic Views
for MDFIC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MDFIC gene promoter:
         c-Fos   AP-1   COMP1   ATF-2   Nkx2-5   c-Jun   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MDFIC promoter sequence
   Search SABiosciences Chromatin IP Primers for MDFIC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MDFIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1-q31.2   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.1-q31.2

MDFIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MDFIC gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P114562:  view genomic region     (about GC identifiers)

Start:
 114,562,209 bp from pter      End:
 114,659,970 bp from pter
Size:
 97,762 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 113,957,476-114,055,279     

Proteins
for MDFIC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7 (See protein sequence)
Recommended Name: MyoD family inhibitor domain-containing protein  
Size: 246 amino acids; 25788 Da
Subunit: Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with
ZIC2 (By similarity). The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of
CCNT1/cyclin-T and weakly with LEF1
Subcellular location: Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm
Subcellular location: Isoform 2: Cytoplasm. Note=Weak expression in the nucleus
Secondary accessions: Q9P1T6
Alternative initiation: 2 isoforms:  Q9P1T7-2   Q9P1T7-1   (Minor isoform. Initiates from a GTG codon. Contains a Nucleolar localization signal at positions 45-63)

Explore the universe of human proteins at neXtProt for MDFIC: NX_Q9P1T7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P1T7

    • MDFIC Protein expression data from MOPED and PaxDb:    About this image 
    MDFIC Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001159817.1  NP_001159818.3  NP_951038.1  

    ENSEMBL proteins: 
     ENSP00000257724   ENSP00000377126   ENSP00000412153   ENSP00000401623   ENSP00000416668  
     ENSP00000392098   ENSP00000418337  

    Human Recombinant Protein Products for MDFIC: 
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    Uscn Proteins for MDFIC

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA10671520
    GO:0005794Golgi apparatus IDA--

    MDFIC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MDFIC

    Protein Domains /
    Families
    for MDFIC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MDFIC for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026134 MDFI/MDFIC

    Graphical View of Domain Structure for InterPro Entry Q9P1T7

    ProtoNet protein and cluster: Q9P1T7

    UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7
    Domain: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity). The
    cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm
    Similarity: Belongs to the MDFI family


    Function
    for MDFIC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MDFIC_HUMAN, Q9P1T7
    Function: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family
    proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the
    expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human
    immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import,
    probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell
    leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free
    beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12192039
    GO:0008134transcription factor binding IPI12192039
    GO:0030332cyclin binding IPI12944466
    GO:0030957Tat protein binding IDA16260749
         
    MDFIC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MDFIC 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MDFIC
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDFIC
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate MDFIC (see all 35):
    hsa-miR-607 hsa-miR-4328 hsa-miR-24-1* hsa-miR-301a hsa-miR-766 hsa-miR-10b* hsa-miR-374c hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: MDFIC 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MDFIC (see all 7)
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for MDFIC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00


    1 BioSystems Pathway for MDFIC 
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MDFIC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for MDFIC (Q9P1T73 ENSP000002577244) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNT1O605633, ENSP000002619004I2D: score=1 STRING: ENSP00000261900
    TATP177353, ENSP000003482344I2D: score=1 STRING: ENSP00000348234
    CDK9P507503, ENSP000003623614I2D: score=1 STRING: ENSP00000362361
    MYF5ENSP000002286444STRING: ENSP00000228644
    MYOGENSP000002416514STRING: ENSP00000241651
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007257activation of JUN kinase activity IDA12192039
    GO:0019048virus-host interaction IEA--
    GO:0030111regulation of Wnt receptor signaling pathway IDA12192039
    GO:0042308negative regulation of protein import into nucleus ISS--

    MDFIC for ontologies           About GeneDecksing



    Drugs & Compounds
    for MDFIC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MDFIC
    Search CenterWatch for drugs/clinical trials and news about MDFIC 

    Transcripts
    for MDFIC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MDFIC gene (3 alternative transcripts): 
    NM_001166345.1  NM_001166346.1  NM_199072.4  

    Unigene Cluster for MDFIC:

    MyoD family inhibitor domain containing
    Hs.741413  [show with all ESTs]
    Unigene Representative Sequence: NM_199072
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257724 ENST00000393486(uc022akf.1 uc003vhf.3) ENST00000448022
    ENST00000423503(uc003vhg.3) ENST00000431629 ENST00000427207 ENST00000498196


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MDFIC
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate MDFIC (see all 35):
    hsa-miR-607 hsa-miR-4328 hsa-miR-24-1* hsa-miR-301a hsa-miR-766 hsa-miR-10b* hsa-miR-374c hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: MDFIC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MDFIC (see all 7)
    OriGene shRNA RFP: MDFIC
    OriGene siRNA: MDFIC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MDFIC
    Sirion Biotech Custom design and validation of potent shRNA sequences against MDFIC 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MDFIC (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MDFIC (NM_001166346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MDFIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MDFIC 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MDFIC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MDFIC

    Additional cDNA sequence: 

    AF054589.1 AY196485.1 BC040713.1 

    6 DOTS entries:

    DT.203476  DT.40307168  DT.40119237  DT.306530  DT.99942109  DT.99943967 

    24/99 AceView cDNA sequences (see all 99):

    AA828329 BQ434566 CA421173 AW778759 AI668639 BI861905 AL701945 CA748571 
    NM_199072 AF054589 BM453859 AV703021 BC040713 AW472996 BG030431 BX479785 
    CD365679 CA430032 AW291802 BM091515 AA748774 CB962860 CA437165 AW130950 

    GeneLoc Exon Structure


    Expression
    for MDFIC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MDFIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTAAGTGCT
    MDFIC Expression
    About this image
    See MDFIC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MDFIC

    SOURCE GeneReport for Unigene cluster: Hs.741413

    UniProtKB/Swiss-Prot: MDFIC_HUMAN, Q9P1T7
    Tissue specificity: Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate,
    uterus and small intestine

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    In Situ
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    Orthologs
    for MDFIC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MDFIC gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MDFIC1 MyoD family inhibitor domain containing 76.82(n)
    73.66(a)    		   417774  XM_416018.3  XP_416018.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MDFIC6
    		 --
    		 72(a)
    		 1 ↔ 1
    		 5(59705423-59719441)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3982132 I-mfa domain protein XIC 75.88(n)    AY017419.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005369171 myoD family inhibitor domain-containing protein-like 68.95(n)
    67.43(a)    		   100536917  XM_003198606.1  XP_003198654.1 


    ENSEMBL Gene Tree for MDFIC (if available)
    TreeFam Gene Tree for MDFIC (if available) 

    Paralogs
    for MDFIC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MDFIC gene
    MDFI2  
    1 SIMAP similar gene for MDFIC using alignment to 6 protein entries:     MDFIC_HUMAN (see all proteins):
    MDFI

    MDFIC for paralogs           About GeneDecksing



    Genomic Variants
    for MDFIC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1626 NCBI SNPs in MDFIC are shown (see all 1626)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2006843801,2
    		C--108954289(+) AACCCC/TAAATG 2 -- int10--------
    rs130928041,2
    		C--108996968(-) caataT/Acatac 2 -- int12Minor allele frequency- A:0.25NA 4
    rs342418281,2
    		C--109017842(+) GCTGG-/AACGAG 2 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs2014251671,2
    		C--109017842(+) GCTGGA/GACGAG 2 -- int10--------
    rs1137571041,2
    		C--113956531(+) CAGGCG/ATGAGC 3 -- us2k12Minor allele frequency- A:0.02WA NA 122
    rs69669991,2
    		C,H--113956806(+) TCTACA/CAATGA 3 -- us2k16Minor allele frequency- C:0.00NS EA NA 508
    rs69671501,2
    		C,H--113956899(+) TTTACA/CCTTGC 3 -- us2k14Minor allele frequency- C:0.00NS EA 416
    rs734412101,2
    		C--113956947(+) TCTCAT/CTTATA 3 -- us2k12Minor allele frequency- C:0.15WA 120
    rs734412111,2
    		C--113957189(+) GAAGTG/AAGTAA 3 -- us2k13Minor allele frequency- A:0.08WA NA 240
    rs759382191,2
    		--113957698(+) CGCAGA/GGGAGC 3 -- ut510--------

    HapMap Linkage Disequilibrium report for MDFIC (114562209 - 114659970 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MDFIC
         1 CNV: 59376

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MDFIC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MDFIC for disorders           About GeneDecksing

    OMIM gene information: 614511    OMIM disorders: --

    5 diseases for MDFIC:    About MalaCards
    iron overload    t-cell leukemia    immunodeficiency    leukemia
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for MDFIC:
    Apraxia     DOID:4019

    2 Novoseek disease relationships for MDFIC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 51.2 2 10671520 (2)
    immunodeficiency 28.9 1 10671520 (1)

    Human Genome Epidemiology (HuGE) Navigator: MDFIC (1 document)

    Export disorders for MDFIC gene to outside databases

    Publications
    for MDFIC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MDFIC gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MDFIC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV- 1 expression. (PubMed id 10671520)1, 2, 3, 9 Thebault S.... Mesnard J.-M. (2000)
    2. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PubMed id 12944466)1, 2, 9 Young T.M.... Mathews M.B. (2003)
    3. I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. (PubMed id 12192039)1, 2, 9 Kusano S. and Raab-Traub N. (2002)
    4. Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. (PubMed id 16260749)1, 2, 9 Gautier V.W.... Hall W.W. (2005)
    5. Sequence requirement for the nucleolar localization of human I-mfa domain-containing protein (HIC p40). (PubMed id 11139147)1, 2, 9 Thebault S.... Mesnard J.-M. (2000)
    6. Expression profile and differential regulation of the Human I-mfa domain-Containing protein (HIC) gene in immune cells. (PubMed id 19428567)1, 9 Gu L....Gautier V.W. (2009)
    7. The complex regulation of HIC (Human I-mfa domain con taining protein) expression. (PubMed id 19582149)1, 9 Reiss-Sklan E....Naveh-Many T. (2009)
    8. The 3'UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells. (PubMed id 19041912)1, 9 Liu J....Chao S.H. (2009)
    9. Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription. (PubMed id 17289077)1, 9 Wang Q....Pe'ery T. (2007)
    10. HIC gene, a candidate suppressor gene within a minimal region of loss at 7q31.1 in myeloid neoplasms. (PubMed id 17064770)1, 9 Cigognini D....Tripputi P. (2007)

    External Searches for MDFIC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MDFIC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29969 HGNC: 28870 AceView: HIC Ensembl:ENSG00000135272 euGenes: HUgn29969
    ECgene: MDFIC H-InvDB: MDFIC

    Other Databases showing MDFIC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MDFIC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MDFIC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MDFIC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MDFIC gene:
    Search GeneIP for patents involving MDFIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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