Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MDFI Gene

Aliases for MDFI Gene

  • MyoD Family Inhibitor 2 3 5
  • Inhibitor Of MyoD Family A 2 3
  • Myogenic Repressor I-Mf 3 4
  • I-Mfa 3
  • I-MF 3

External Ids for MDFI Gene

Previous GeneCards Identifiers for MDFI Gene

  • GC06P041606
  • GC06P041653
  • GC06P041714
  • GC06P041324

Summaries for MDFI Gene

Entrez Gene Summary for MDFI Gene

  • This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]

GeneCards Summary for MDFI Gene

MDFI (MyoD Family Inhibitor) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is MDFIC.

UniProtKB/Swiss-Prot for MDFI Gene

  • Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).

Gene Wiki entry for MDFI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDFI Gene

Genomics for MDFI Gene

Regulatory Elements for MDFI Gene

Enhancers for MDFI Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MDFI on UCSC Golden Path with GeneCards custom track

Promoters for MDFI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MDFI on UCSC Golden Path with GeneCards custom track

Genomic Location for MDFI Gene

Chromosome:
6
Start:
41,636,882 bp from pter
End:
41,654,246 bp from pter
Size:
17,365 bases
Orientation:
Plus strand

Genomic View for MDFI Gene

Genes around MDFI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDFI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDFI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDFI Gene

Proteins for MDFI Gene

  • Protein details for MDFI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99750-MDFI_HUMAN
    Recommended name:
    MyoD family inhibitor
    Protein Accession:
    Q99750

    Protein attributes for MDFI Gene

    Size:
    246 amino acids
    Molecular mass:
    25029 Da
    Quaternary structure:
    • The C-terminus interacts with AXIN1 and LEF1 (By similarity). Interacts with CCNT2 (PubMed:17289077).

neXtProt entry for MDFI Gene

Proteomics data for MDFI Gene at MOPED

Post-translational modifications for MDFI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MDFI Gene

Domains & Families for MDFI Gene

Protein Domains for MDFI Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MDFI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99750

UniProtKB/Swiss-Prot:

MDFI_HUMAN :
  • Belongs to the MDFI family.
Family:
  • Belongs to the MDFI family.
genes like me logo Genes that share domains with MDFI: view

No data available for Gene Families for MDFI Gene

Function for MDFI Gene

Molecular function for MDFI Gene

GENATLAS Biochemistry:
myogenic factor D family (MYOD) inhibitor homolog of mouse I-mfa,expressed in the sclerotome,involved in the patterning of somites
UniProtKB/Swiss-Prot Function:
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).

Gene Ontology (GO) - Molecular Function for MDFI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with MDFI: view
genes like me logo Genes that share phenotypes with MDFI: view

Animal Models for MDFI Gene

MGI Knock Outs for MDFI:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDFI Gene

Localization for MDFI Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDFI Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MDFI Gene COMPARTMENTS Subcellular localization image for MDFI gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
extracellular 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for MDFI Gene

Pathways & Interactions for MDFI Gene

SuperPathways for MDFI Gene

No Data Available

Gene Ontology (GO) - Biological Process for MDFI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0007257 activation of JUN kinase activity IEA --
GO:0009790 embryo development TAS 8797820
GO:0009950 dorsal/ventral axis specification IEA,ISS --
GO:0030111 regulation of Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with MDFI: view

No data available for Pathways by source and SIGNOR curated interactions for MDFI Gene

Drugs & Compounds for MDFI Gene

No Compound Related Data Available

Transcripts for MDFI Gene

Unigene Clusters for MDFI Gene

MyoD family inhibitor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MDFI Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6:
SP7: -

Relevant External Links for MDFI Gene

GeneLoc Exon Structure for
MDFI
ECgene alternative splicing isoforms for
MDFI

Expression for MDFI Gene

mRNA expression in normal human tissues for MDFI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MDFI Gene

This gene is overexpressed in Esophagus - Mucosa (x5.5) and Adipose - Visceral (Omentum) (x5.0).

SOURCE GeneReport for Unigene cluster for MDFI Gene Hs.520119

genes like me logo Genes that share expression patterns with MDFI: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MDFI Gene

Orthologs for MDFI Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDFI Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MDFI 35
  • 90.51 (n)
  • 89.02 (a)
MDFI 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MDFI 35
  • 92.28 (n)
  • 91.46 (a)
MDFI 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mdfi 35
  • 83.74 (n)
  • 79.51 (a)
Mdfi 16
Mdfi 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MDFI 35
  • 99.46 (n)
  • 99.19 (a)
MDFI 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdfi 35
  • 85.03 (n)
  • 82.86 (a)
oppossum
(Monodelphis domestica)
Mammalia MDFI 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDFI 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859031 35
  • 73.63 (n)
  • 68.16 (a)
MDFI 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MDFI 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mdfi 35
  • 55.08 (n)
  • 51.22 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537791 35
  • 68.71 (n)
  • 64.42 (a)
MDFI 36
  • 45 (a)
OneToOne
Species with no ortholog for MDFI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDFI Gene

ENSEMBL:
Gene Tree for MDFI (if available)
TreeFam:
Gene Tree for MDFI (if available)

Paralogs for MDFI Gene

Paralogs for MDFI Gene

(1) SIMAP similar genes for MDFI Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MDFI: view

Variants for MDFI Gene

Sequence variations from dbSNP and Humsavar for MDFI Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1008895 -- 41,652,983(+) ataga(G/T)tcatt intron-variant
rs1056684 -- 41,653,880(+) TGGGG(A/G)CCGCA utr-variant-3-prime
rs1056686 -- 41,653,887(+) CGCAG(A/G/T)GGGCA utr-variant-3-prime
rs1134905 -- 41,646,304(+) GCTGT(G/T)ACATG intron-variant, reference, synonymous-codon
rs1204422 -- 41,650,988(-) cctca(A/G)gtgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MDFI Gene

Variant ID Type Subtype PubMed ID
nsv885830 CNV Loss 21882294
dgv1943e1 CNV Complex 17122850
dgv1944e1 CNV Complex 17122850
esv2109973 CNV Deletion 18987734
esv2731976 CNV Deletion 23290073
esv2657739 CNV Deletion 23128226
nsv519925 CNV Loss 19592680
dgv1945e1 CNV Complex 17122850

Variation tolerance for MDFI Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MDFI Gene

Disorders for MDFI Gene

Relevant External Links for MDFI

Genetic Association Database (GAD)
MDFI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MDFI

No disorders were found for MDFI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MDFI Gene

Publications for MDFI Gene

  1. Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription. (PMID: 17289077) Wang Q. … Pe'ery T. (J. Mol. Biol. 2007) 2 3 4 23 67
  2. The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17. (PMID: 9250874) Kraut N. (Mamm. Genome 1997) 2 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. (PMID: 25261932) Cerhan J.R. … Chanock S.J. (Nat. Genet. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for MDFI Gene

Sources for MDFI Gene

Content