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Aliases for MCUR1 Gene

Aliases for MCUR1 Gene

  • Mitochondrial Calcium Uniporter Regulator 1 2 3
  • Coiled-Coil Domain-Containing Protein 90A, Mitochondrial 3 4
  • Coiled-Coil Domain Containing 90A 2 3
  • C6orf79 3 4
  • CCDC90A 3 4
  • Chromosome 6 Open Reading Frame 79 2

External Ids for MCUR1 Gene

Previous Symbols for MCUR1 Gene

  • C6orf79
  • CCDC90A

Summaries for MCUR1 Gene

GeneCards Summary for MCUR1 Gene

MCUR1 (Mitochondrial Calcium Uniporter Regulator 1) is a Protein Coding gene. An important paralog of this gene is CCDC90B.

UniProtKB/Swiss-Prot for MCUR1 Gene

  • Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCUR1 Gene

Genomics for MCUR1 Gene

Genomic Location for MCUR1 Gene

Start:
13,786,549 bp from pter
End:
13,814,568 bp from pter
Size:
28,020 bases
Orientation:
Minus strand

Genomic View for MCUR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCUR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCUR1 Gene

No data available for Regulatory Elements for MCUR1 Gene

Proteins for MCUR1 Gene

  • Protein details for MCUR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AQ8-MCUR1_HUMAN
    Recommended name:
    Mitochondrial calcium uniporter regulator 1
    Protein Accession:
    Q96AQ8
    Secondary Accessions:
    • Q96JS7
    • Q9H7F8

    Protein attributes for MCUR1 Gene

    Size:
    359 amino acids
    Molecular mass:
    39694 Da
    Quaternary structure:
    • Interacts with MCU.

    Alternative splice isoforms for MCUR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCUR1 Gene

Proteomics data for MCUR1 Gene at MOPED

Post-translational modifications for MCUR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCUR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCUR1 Gene

Domains for MCUR1 Gene

Protein Domains for MCUR1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MCUR1_HUMAN
Family:
  • Belongs to the CCDC90 family.:
    • Q96AQ8
genes like me logo Genes that share domains with MCUR1: view

No data available for Gene Families for MCUR1 Gene

Function for MCUR1 Gene

Molecular function for MCUR1 Gene

UniProtKB/Swiss-Prot Function: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU.

Gene Ontology (GO) - Molecular Function for MCUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23178883
genes like me logo Genes that share ontologies with MCUR1: view

miRNA for MCUR1 Gene

miRTarBase miRNAs that target MCUR1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCUR1 Gene

Localization for MCUR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCUR1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MCUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031305 integral component of mitochondrial inner membrane IDA 23178883
genes like me logo Genes that share ontologies with MCUR1: view

Pathways for MCUR1 Gene

SuperPathways for MCUR1 Gene

No Data Available

Interacting Proteins for MCUR1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368468%0d%0a9606.ENSP00000361057%0d%0a9606.ENSP00000253237%0d%0a9606.ENSP00000428765%0d%0a9606.ENSP00000305653%0d%0a
Selected Interacting proteins: ENSP00000368468 for MCUR1 Gene via STRING

Gene Ontology (GO) - Biological Process for MCUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006851 mitochondrial calcium ion transport IMP 23178883
GO:0051561 positive regulation of mitochondrial calcium ion concentration IMP 23178883
GO:0070509 calcium ion import IMP 23178883
genes like me logo Genes that share ontologies with MCUR1: view

No data available for Pathways by source for MCUR1 Gene

Transcripts for MCUR1 Gene

Unigene Clusters for MCUR1 Gene

Mitochondrial calcium uniporter regulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCUR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:

Relevant External Links for MCUR1 Gene

GeneLoc Exon Structure for
MCUR1
ECgene alternative splicing isoforms for
MCUR1

Expression for MCUR1 Gene

mRNA expression in normal human tissues for MCUR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCUR1 Gene

SOURCE GeneReport for Unigene cluster for MCUR1 Gene Hs.214043

mRNA Expression by UniProt/SwissProt for MCUR1 Gene

Q96AQ8-MCUR1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with MCUR1: view

Orthologs for MCUR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MCUR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC90A 36
  • 99.44 (n)
  • 98.89 (a)
MCUR1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC90A 36
  • 82.36 (n)
  • 75.21 (a)
CCDC90A 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCUR1 36
  • 91.87 (n)
  • 91.87 (a)
MCUR1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc90a 16
Mcur1 36
  • 77.11 (n)
  • 75.9 (a)
Mcur1 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCUR1 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCUR1 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcur1 36
  • 77.51 (n)
  • 76.81 (a)
chicken
(Gallus gallus)
Aves CCDC90A 36
  • 68.35 (n)
  • 67.44 (a)
MCUR1 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCUR1 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19315 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mcur1 36
  • 65.71 (n)
  • 63.37 (a)
Str.19448 36
zebrafish
(Danio rerio)
Actinopterygii MCUR1 37
  • 56 (a)
OneToOne
wufb37a05 36
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP32 39
Species with no ortholog for MCUR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCUR1 Gene

ENSEMBL:
Gene Tree for MCUR1 (if available)
TreeFam:
Gene Tree for MCUR1 (if available)

Paralogs for MCUR1 Gene

Paralogs for MCUR1 Gene

Selected SIMAP similar genes for MCUR1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MCUR1 Gene

genes like me logo Genes that share paralogs with MCUR1: view

Variants for MCUR1 Gene

Sequence variations from dbSNP and Humsavar for MCUR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1053033 -- 13,786,852(-) CACAT(C/G/T)TTACA utr-variant-3-prime
rs1060117 -- 13,787,695(-) CTCTA(G/T)GTGCA utr-variant-3-prime
rs1204144 -- 13,813,990(+) GCCCC(C/T)TCTCC intron-variant
rs1204145 - 13,814,108(+) CGCGC(C/T)GCTGC reference, missense, nc-transcript-variant
rs1204146 -- 13,815,536(+) AGTTT(A/C)GCAAT upstream-variant-2KB

Relevant External Links for MCUR1 Gene

HapMap Linkage Disequilibrium report
MCUR1

No data available for Structural Variations from Database of Genomic Variants (DGV) for MCUR1 Gene

Disorders for MCUR1 Gene

No disorders were found for MCUR1 Gene.

No data available for UniProtKB/Swiss-Prot for MCUR1 Gene

Publications for MCUR1 Gene

  1. MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism. (PMID: 23178883) Mallilankaraman K. … Madesh M. (Nat. Cell Biol. 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for MCUR1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MCUR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MCUR1
    • Block miRNA regulation of MCUR1 using miScript Target Protectors

    Sources for MCUR1 Gene

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