Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MCUB Gene

Aliases for MCUB Gene

  • Mitochondrial Calcium Uniporter Dominant Negative Beta Subunit 2 3 5
  • Coiled-Coil Domain-Containing Protein 109B 3 4
  • Coiled-Coil Domain Containing 109B 2 3
  • CCDC109B 3 4
  • Calcium Uniporter Regulatory Subunit MCUb, Mitochondrial 3
  • Mitochondrial Calcium Uniporter Regulatory Subunit MCUb 3
  • MCUb 4

External Ids for MCUB Gene

Previous HGNC Symbols for MCUB Gene

  • CCDC109B

Summaries for MCUB Gene

GeneCards Summary for MCUB Gene

MCUB (Mitochondrial Calcium Uniporter Dominant Negative Beta Subunit) is a Protein Coding gene. An important paralog of this gene is MCU.

UniProtKB/Swiss-Prot for MCUB Gene

  • Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCUB Gene

Genomics for MCUB Gene

Regulatory Elements for MCUB Gene

Enhancers for MCUB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F109548 1 FANTOM5 Ensembl ENCODE 7.7 -11.4 -11439 1.5 ZNF316 JUND JUN EMSY MAFK CFI MCUB RBMXP4 SEC24B SETP20 MIR576
GH04F109574 0.8 Ensembl ENCODE 5.3 +14.4 14364 0.9 ELF3 CTCF ZNF654 ELF1 RAD21 TEAD3 HDAC2 SMARCA4 TRIM28 MCUB GC04P109564 HIGD1AP14
GH04F109559 0.2 ENCODE 0.8 +0.3 318 2.7 HDGF PKNOX1 ATF1 SIN3A FEZF1 ZNF2 GLIS2 CBX5 ZNF263 TBX21 SEC24B SEC24B-AS1 SETP20 CDC42P4 PIR49237 MCUB
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MCUB on UCSC Golden Path with GeneCards custom track

Promoters for MCUB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001434095 301 2601 HDGF PKNOX1 ATF1 SIN3A FEZF1 ZNF2 GLIS2 CBX5 FOS ZNF263

Genomic Location for MCUB Gene

Chromosome:
4
Start:
109,560,199 bp from pter
End:
109,688,726 bp from pter
Size:
128,528 bases
Orientation:
Plus strand

Genomic View for MCUB Gene

Genes around MCUB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCUB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCUB Gene

Proteins for MCUB Gene

  • Protein details for MCUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWR8-MCUB_HUMAN
    Recommended name:
    Calcium uniporter regulatory subunit MCUb, mitochondrial
    Protein Accession:
    Q9NWR8
    Secondary Accessions:
    • A8K4Y3
    • Q6IAC1

    Protein attributes for MCUB Gene

    Size:
    336 amino acids
    Molecular mass:
    39082 Da
    Quaternary structure:
    • Heterooligomer with MCU; this reduces MCU channel activity. Homooligomer (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.
    SequenceCaution:
    • Sequence=AAH02633.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91309.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MCUB Gene

Post-translational modifications for MCUB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCUB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCUB Gene

Domains & Families for MCUB Gene

Protein Domains for MCUB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCUB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWR8

UniProtKB/Swiss-Prot:

MCUB_HUMAN :
  • Belongs to the MCU (TC 1.A.77) family.
Family:
  • Belongs to the MCU (TC 1.A.77) family.
genes like me logo Genes that share domains with MCUB: view

No data available for Gene Families for MCUB Gene

Function for MCUB Gene

Molecular function for MCUB Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.

Gene Ontology (GO) - Molecular Function for MCUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 NOT ion channel activity ISS --
GO:0005262 NOT calcium channel activity IBA --
GO:0015292 NOT uniporter activity IBA --
GO:0019855 calcium channel inhibitor activity IEA,ISS --
genes like me logo Genes that share ontologies with MCUB: view
genes like me logo Genes that share phenotypes with MCUB: view

Animal Models for MCUB Gene

MGI Knock Outs for MCUB:

Animal Model Products

miRNA for MCUB Gene

miRTarBase miRNAs that target MCUB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCUB Gene

Localization for MCUB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCUB Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MCUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane IEA,ISS --
genes like me logo Genes that share ontologies with MCUB: view

No data available for Subcellular locations from COMPARTMENTS for MCUB Gene

Pathways & Interactions for MCUB Gene

SuperPathways for MCUB Gene

No Data Available

Interacting Proteins for MCUB Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378145%0d%0a9606.ENSP00000354415%0d%0a9606.ENSP00000327467%0d%0a9606.ENSP00000371811%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000362144%0d%0a
Selected Interacting proteins: ENSP00000378145 Q9NWR8-MCUB_HUMAN for MCUB Gene via STRING IID

Gene Ontology (GO) - Biological Process for MCUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0006851 mitochondrial calcium ion transport IEA,ISS --
GO:0036444 mitochondrial calcium uptake IBA --
genes like me logo Genes that share ontologies with MCUB: view

No data available for Pathways by source and SIGNOR curated interactions for MCUB Gene

Transcripts for MCUB Gene

Unigene Clusters for MCUB Gene

Coiled-coil domain containing 109B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCUB Gene

No ASD Table

Relevant External Links for MCUB Gene

GeneLoc Exon Structure for
MCUB
ECgene alternative splicing isoforms for
MCUB

Expression for MCUB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MCUB Gene:

MCUB

SOURCE GeneReport for Unigene cluster for MCUB Gene:

Hs.234149
genes like me logo Genes that share expression patterns with MCUB: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MCUB Gene

Orthologs for MCUB Gene

This gene was present in the common ancestor of animals.

Orthologs for MCUB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC109B 35 34
  • 99.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC109B 35 34
  • 86.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC109B 35 34
  • 85.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc109b 34
  • 77.58 (n)
mouse
(Mus musculus)
Mammalia Ccdc109b 35 16 34
  • 77.48 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC109B 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC109B 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC109B 35 34
  • 68.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC109B 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc109b 34
  • 63.86 (n)
Str.15484 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21402 34
fruit fly
(Drosophila melanogaster)
Insecta CG18769 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mcu-1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for MCUB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MCUB Gene

ENSEMBL:
Gene Tree for MCUB (if available)
TreeFam:
Gene Tree for MCUB (if available)

Paralogs for MCUB Gene

Paralogs for MCUB Gene

genes like me logo Genes that share paralogs with MCUB: view

Variants for MCUB Gene

Sequence variations from dbSNP and Humsavar for MCUB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4698775 untested 109,669,323(+) ttctc(G/T)gaatg intron-variant
rs10004265 -- 109,609,142(+) ctccc(A/G)atcca intron-variant
rs10005056 -- 109,626,735(+) TTGAA(A/C)CCAGG intron-variant
rs10006379 -- 109,569,326(+) caggc(A/G)ttagc intron-variant
rs10006490 -- 109,585,013(+) ttaat(A/T)ttctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCUB Gene

Variant ID Type Subtype PubMed ID
dgv2876n106 CNV deletion 24896259
esv2350206 CNV deletion 18987734
esv2518482 CNV deletion 19546169
esv2658349 CNV deletion 23128226
esv2728129 CNV deletion 23290073
esv3332433 CNV insertion 20981092
esv3474 CNV loss 18987735
esv3564431 CNV deletion 23714750
esv3894003 CNV loss 25118596
esv7767 CNV loss 19470904
nsv1074744 CNV deletion 25765185
nsv1123828 CNV deletion 24896259
nsv1149565 CNV deletion 26484159
nsv292142 CNV deletion 16902084
nsv461613 CNV gain 19166990
nsv508303 CNV deletion 20534489
nsv595129 CNV gain 21841781
nsv822683 CNV gain 20364138
nsv956420 CNV deletion 24416366
nsv967783 CNV duplication 23825009
nsv967784 CNV duplication 23825009

Variation tolerance for MCUB Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.23; 88.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCUB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCUB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCUB Gene

Disorders for MCUB Gene

Relevant External Links for MCUB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCUB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCUB

No disorders were found for MCUB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCUB Gene

Publications for MCUB Gene

  1. The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. (PMID: 23900286) Raffaello A. … Rizzuto R. (EMBO J. 2013) 2 3 64
  2. EMRE is an essential component of the mitochondrial calcium uniporter complex. (PMID: 24231807) Sancak Y. … Mootha V.K. (Science 2013) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MCUB Gene

Sources for MCUB Gene

Content
Loading form....