Aliases for MCU Gene
External Ids for MCU Gene
Previous HGNC Symbols for MCU Gene
Previous GeneCards Identifiers for MCU Gene
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for MCU Gene
MCU (Mitochondrial Calcium Uniporter) is a Protein Coding gene. Diseases associated with MCU include Acute Cystitis and Bladder Disease. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include identical protein binding and uniporter activity. An important paralog of this gene is CCDC109B.
UniProtKB/Swiss-Prot for MCU Gene
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:26341627). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213).