MCU Gene

Aliases
for MCU gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Summaries
for MCU gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MCU gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000010.10  NC_018921.2  NT_030059.14  

SwitchGear Promoter luciferase reporter plasmid: MCU promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCU

MCU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074452:  view genomic region     (about GC identifiers)

Proteins
for MCU gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for MCU: NX_Q8NE86

Explore proteomics data for MCU at MOPED

Post-translational modifications: 

MCU Human Recombinant Protein Products:

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	antibodies-online proteins for MCU (2 products)
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MCU Antibody Products:

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	antibodies-online antibodies for MCU

MCU Assay Products:

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	Cloud-Clone Corp. ELISAs for MCU Cloud-Clone Corp. CLIAs for MCU
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	antibodies-online kits for MCU (12 products)

Domains /
Families
for MCU gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8NE86

Find genes that share domains with MCU           About GenesLikeMe

Function
for MCU gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for MCU

miRNA Products:		miRTarBase miRNAs that target MCU: hsa-mir-10a-5p (MIRT047735), hsa-mir-23a-3p (MIRT050443), hsa-mir-16-5p (MIRT005270)
		Block miRNA regulation of human, mouse, rat MCU using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MCU (see all 16):
		hsa-miR-520a-5p hsa-miR-548m hsa-miR-124 hsa-miR-3613-3p hsa-miR-205* hsa-miR-129-3p hsa-miR-506 hsa-miR-129*
		SwitchGear 3'UTR luciferase reporter plasmid: MCU 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MCU
		Predesigned siRNA for gene silencing in human, mouse, rat MCU

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MCU

Clone Products:		OriGene clones in human, mouse for MCU (see all 5) OriGene ORF clones in mouse, rat for MCU OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for MCU
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCU
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCU
		Addgene plasmids for MCU

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MCU
		Browse ESI BIO Cell Lines and PureStem Progenitors for MCU

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCU

Localization
for MCU gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for MCU gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for MCU gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MCU gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MCU gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MCU expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTAAAATCC

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for MCU OriGene qSTAR qPCR primer pairs in human, mouse for MCU
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCU
		QuantiTect SYBR Green Assays in human, mouse, rat MCU
		QuantiFast Probe-based Assays in human, mouse, rat MCU

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCU

Orthologs
for MCU gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MCU gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for MCU gene

CCDC109B²  

1 SIMAP similar gene for MCU using alignment to 6 protein entries:     MCU_HUMAN (see all proteins):

CCDC109B

Find genes that share paralogs with MCU           About GenesLikeMe

Genomic Variants
for MCU gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MCU (see all 3316)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs763975591,2	C,F	--	74449909(+)	TATGAG/ATAAAT	3	--	us2k1		1		EA	120
rs1499452591,2	C	--	74449921(+)	TCACTG/TCAGGA	3	--	us2k1		0	--	--	--	--
rs1451432371,2		--	74450194(+)	GTTCCA/GGGAAT	3	--	us2k1		0	--	--	--	--
rs1490314531,2		--	74450258(+)	CATTCC/TTGAGG	3	--	us2k1		0	--	--	--	--
rs30095591,2	C,F,A,H	--	74450319(-)	CGGGGT/GAGATA	3	--	us2k1 tfbs3		24		NS EA NA WA CSA	2350
rs1432051171,2		--	74450360(+)	AGGTGG/TGGCAT	3	--	us2k1		0	--	--	--	--
rs1466890571,2		--	74450434(+)	ATTTCA/TGTCAA	4	--	us2k1		0	--	--	--	--
rs1931195401,2		--	74450490(+)	TTTATA/GTGTGT	4	--	us2k1		0	--	--	--	--
rs664614521,2	C	--	74450843(+)	TTTTTT/-TTTTT	4	--	us2k1		1		NA	2
rs1402722691,2	C	--	74450873(+)	GTCTTA/GCTGTG	4	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MCU (74451889 - 74647452 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MCU:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv7121	CNV	Insertion	18451855
nsv895722	CNV	Loss	21882294
nsv895723	CNV	Loss	21882294
dgv299e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MCU

DNA2.0 Custom Variant and Variant Library Synthesis for MCU

Disorders / Diseases
for MCU gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MCU gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. (PubMed id 21685888)^{1, 2, 3} De Stefani D.... Rizzuto R. (Nature 2011)
2. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. (PubMed id 21685886)^{1, 2, 3} Baughman J.M.... Mootha V.K. (Nature 2011)
3. Evolutionary diversity of the mitochondrial calcium uniporter. (PubMed id 22605770)^{1, 2} Bick A.G.... Mootha V.K. (Science 2012)
4. Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic beta-cells. (PubMed id 22904319)^{1, 2} Alam M.R.... Graier W.F. (J. Biol. Chem. 2012)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles. (PubMed id 23400777)¹ Patron M....Rizzuto R. (J. Biol. Chem. 2013)
7. Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. (PubMed id 23602897)¹ Curry M.C....Monteith G.R. (Biochem. Biophys. Res. Commun. 2013)
8. EMRE is an essential component of the mitochondrial calcium uniporter complex. (PubMed id 24231807)² Sancak Y.... Mootha V.K. (Science 2013)
9. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
10. Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. (PubMed id 22123069)¹ CsordA!s G....HajnA^czky G. (Mol. Cell. Endocrinol. 2012)

External Searches for MCU gene

Genome Databases showing MCU gene

Other Databases showing MCU gene

Specialized Databases showing MCU gene

Products
for MCU gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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