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MCU Gene

protein-coding   GIFtS: 44
GCID: GC10P074452

Mitochondrial Calcium Uniporter

(Previous name: coiled-coil domain containing 109A)
(Previous symbols: C10orf42, CCDC109A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Calcium Uniporter1 2
CCDC109A1 2 3 5
C10orf421 2 3
Coiled-Coil Domain-Containing Protein 109A2 3
Coiled-Coil Domain Containing 109A1
Calcium Uniporter Protein, Mitochondrial2

External Ids:    HGNC: 235261   Entrez Gene: 905502   Ensembl: ENSG000001560267   OMIM: 6141975   UniProtKB: Q8NE863   

Export aliases for MCU gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MCU Gene:
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein
interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jul 2012)

GeneCards Summary for MCU Gene:
MCU (mitochondrial calcium uniporter) is a protein-coding gene. GO annotations related to this gene include calcium channel activity and uniporter activity. An important paralog of this gene is CCDC109B.

UniProtKB/Swiss-Prot: MCU_HUMAN, Q8NE86
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria.
Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics,
cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion
in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of
systolic calcium rises in cardiomyocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MCU
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCU promoter sequence
   Search Chromatin IP Primers for MCU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2

MCU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCU gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074452:  view genomic region     (about GC identifiers)

Start:
74,451,889 bp from pter      End:
74,647,452 bp from pter
Size:
195,564 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MCU_HUMAN, Q8NE86 (See protein sequence)
Recommended Name: Calcium uniporter protein, mitochondrial  
Size: 351 amino acids; 39867 Da
Subunit: Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. Heterotetramer with
CCDC109B/MCUB; this inhibits channel activity (By similarity). Homotetramer. Interacts with MICU1; MICU1 acts as
an essential gatekeeper for MCU. Interacts with MCUR1; interaction with MICU1 and MCUR1 are mutually exclusive
Secondary accessions: B2RDF3 B3KXV7 Q96FL3
Alternative splicing: 3 isoforms:  Q8NE86-1   Q8NE86-2   Q8NE86-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCU: NX_Q8NE86

Explore proteomics data for MCU at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MCU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257608.1  NP_001257609.1  NP_612366.1  

    ENSEMBL proteins: 
     ENSP00000362144   ENSP00000474265   ENSP00000474820   ENSP00000473857   ENSP00000349680  
     ENSP00000473892   ENSP00000475141   ENSP00000440913  

    MCU Human Recombinant Protein Products:

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    Novus Biologicals MCU Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCU

     
    Search eBioscience for Proteins for MCU 

     
    antibodies-online proteins for MCU (2 products) 

     
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    antibodies-online antibodies for MCU 

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    antibodies-online kits for MCU (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006769 Coiled-coil-dom_prot_109_C

    Graphical View of Domain Structure for InterPro Entry Q8NE86

    ProtoNet protein and cluster: Q8NE86

    UniProtKB/Swiss-Prot: MCU_HUMAN, Q8NE86
    Similarity: Belongs to the MCU family


    Find genes that share domains with MCU           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCU_HUMAN, Q8NE86
    Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria.
    Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics,
    cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion
    in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of
    systolic calcium rises in cardiomyocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005262calcium channel activity IDA--
    GO:0005515protein binding IPI--
    GO:0015292uniporter activity IDA--
         
    Find genes that share ontologies with MCU           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MCU
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCU
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    miRNA
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    miRTarBase miRNAs that target MCU:
    hsa-mir-10a-5p (MIRT047735), hsa-mir-23a-3p (MIRT050443), hsa-mir-16-5p (MIRT005270)

    Block miRNA regulation of human, mouse, rat MCU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCU (see all 16):
    hsa-miR-520a-5p hsa-miR-548m hsa-miR-124 hsa-miR-3613-3p hsa-miR-205* hsa-miR-129-3p hsa-miR-506 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidMCU 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MCU

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCU
    Addgene plasmids for MCU 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCU_HUMAN, Q8NE86: Mitochondrion inner membrane; Multi-pass membrane protein

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IDA--
    GO:0031305integral component of mitochondrial inner membrane IDA--
    GO:0034704calcium channel complex ISS--
    GO:1990246uniplex complex IDA--

    Find genes that share ontologies with MCU           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MCU
    Interactions:

        Search GeneGlobe Interaction Network for MCU

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for MCU (Q8NE862, 3 ENSP000003621444) via UniProtKB, MINT, STRING, and/or I2D (see all 246)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    YWHABP319463I2D: score=1 
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006851mitochondrial calcium ion transport IMP--
    GO:0019722calcium-mediated signaling IDA--
    GO:0032024positive regulation of insulin secretion IMP--
    GO:0035786protein complex oligomerization IDA--
    GO:0042593glucose homeostasis IMP--

    Find genes that share ontologies with MCU           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MCU



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MCU gene (3 alternative transcripts): 
    NM_001270679.1  NM_001270680.1  NM_138357.2  

    Unigene Cluster for MCU:

    Mitochondrial calcium uniporter
    Hs.591366  [show with all ESTs]
    Unigene Representative Sequence: NM_001270680
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373053(uc009xqp.1 uc009xqq.1 uc010qjy.1 uc001jtc.3)
    ENST00000603649 ENST00000604372 ENST00000604679 ENST00000357157(uc009xqr.3)
    ENST00000605597 ENST00000604152 ENST00000483185 ENST00000603118 ENST00000605416
    ENST00000536019(uc001jtd.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MCU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCU (see all 16):
    hsa-miR-520a-5p hsa-miR-548m hsa-miR-124 hsa-miR-3613-3p hsa-miR-205* hsa-miR-129-3p hsa-miR-506 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidMCU 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MCU
    Clone
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    OriGene ORF clones in mouse, rat for MCU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MCU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCU
    Addgene plasmids for MCU 
    Primer
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    OriGene qPCR primer pairs and template standards for MCU
    OriGene qSTAR qPCR primer pairs in human, mouse for MCU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCU
      QuantiTect SYBR Green Assays in human, mouse, rat MCU
      QuantiFast Probe-based Assays in human, mouse, rat MCU

    Additional mRNA sequence: 

    AK025699.1 AK075439.1 AK128016.1 AK301475.1 AK310455.1 AK311133.1 AK315519.1 BC010682.1 
    BC034235.1 NR_073062.1 

    6 DOTS entries:

    DT.445998  DT.100801405  DT.121299991  DT.121300003  DT.100665887  DT.99968136 

    Selected AceView cDNA sequences (see all 138):

    CD519985 BU617819 AA884837 NM_138357 AK025699 AK128016 BM986978 BC034235 
    AA868007 BQ228499 BM754070 BX478050 BC010682 AW438592 T77889 AA582557 
    BF513607 BX482619 CK429538 BM802145 BQ638078 AA653386 AI863290 BM550689 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MCU (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14
    SP1:        -     -     -     -     -                       -                 -     -     -                 -         
    SP2:        -     -     -     -     -                       -           -     -                             -         
    SP3:              -     -     -     -                       -           -     -                             -         
    SP4:        -           -                                                                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for MCU

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MCU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAAATCC
    MCU Expression
    About this image

    MCU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591366
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MCU gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcu1 , 5 coiled-coil domain containing 109A5
    mitochondrial calcium uniporter1
    88.19(n)1
    96.24(a)1
      10 (29.55 cM)5
    2159991  NM_001033259.41  NP_001028431.21 
     594469845 
    chicken
    (Gallus gallus)
    Aves MCU1 mitochondrial calcium uniporter 81.7(n)
    89.59(a)
      428942  XM_426497.4  XP_426497.2 
    lizard
    (Anolis carolinensis)
    Reptilia MCU6
    mitochondrial calcium uniporter
    86(a)
    1 ↔ 1
    3(52263960-52403218)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX845810.12   -- 76.95(n)    BX845810.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM317106.12   -- 75.54(n)    BM317106.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG187691 CG18769 50.7(n)
    46.6(a)
      59223  NM_168169.3  NP_729173.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mcu-11 mcu-1 49.94(n)
    43.22(a)
      177362  NM_068491.4  NP_500892.1 


    ENSEMBL Gene Tree for MCU (if available)
    TreeFam Gene Tree for MCU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MCU gene
    CCDC109B2  
    1 SIMAP similar gene for MCU using alignment to 6 protein entries:     MCU_HUMAN (see all proteins):
    CCDC109B

    Find genes that share paralogs with MCU           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCU (see all 3316)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs763975591,2
    C,F--74449909(+) TATGAG/ATAAAT 3 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1499452591,2
    C--74449921(+) TCACTG/TCAGGA 3 -- us2k10--------
    rs1451432371,2
    --74450194(+) GTTCCA/GGGAAT 3 -- us2k10--------
    rs1490314531,2
    --74450258(+) CATTCC/TTGAGG 3 -- us2k10--------
    rs30095591,2
    C,F,A,H--74450319(-) CGGGGT/GAGATA 3 -- us2k1 tfbs324Minor allele frequency- G:0.49NS EA NA WA CSA 2350
    rs1432051171,2
    --74450360(+) AGGTGG/TGGCAT 3 -- us2k10--------
    rs1466890571,2
    --74450434(+) ATTTCA/TGTCAA 4 -- us2k10--------
    rs1931195401,2
    --74450490(+) TTTATA/GTGTGT 4 -- us2k10--------
    rs664614521,2
    C--74450843(+) TTTTTT/-TTTTT 4 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1402722691,2
    C--74450873(+) GTCTTA/GCTGTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MCU (74451889 - 74647452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MCU:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7121CNV Insertion18451855
    nsv895722CNV Loss21882294
    nsv895723CNV Loss21882294
    dgv299e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MCU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614197    OMIM disorders: --


    Find genes that share disorders with MCU           About GenesLikeMe


    Export disorders for MCU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MCU gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MCU)
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    1. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. (PubMed id 21685888)1, 2, 3 De Stefani D.... Rizzuto R. (Nature 2011)
    2. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. (PubMed id 21685886)1, 2, 3 Baughman J.M.... Mootha V.K. (Nature 2011)
    3. Evolutionary diversity of the mitochondrial calcium uniporter. (PubMed id 22605770)1, 2 Bick A.G.... Mootha V.K. (Science 2012)
    4. Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic beta-cells. (PubMed id 22904319)1, 2 Alam M.R.... Graier W.F. (J. Biol. Chem. 2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles. (PubMed id 23400777)1 Patron M....Rizzuto R. (J. Biol. Chem. 2013)
    7. Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. (PubMed id 23602897)1 Curry M.C....Monteith G.R. (Biochem. Biophys. Res. Commun. 2013)
    8. EMRE is an essential component of the mitochondrial calcium uniporter complex. (PubMed id 24231807)2 Sancak Y.... Mootha V.K. (Science 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. (PubMed id 22123069)1 CsordA!s G....HajnA^czky G. (Mol. Cell. Endocrinol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90550 HGNC: 23526 AceView: C10orf42 Ensembl:ENSG00000156026 euGenes: HUgn90550
    ECgene: MCU H-InvDB: MCU

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MCU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MCU gene:
    Search GeneIP for patents involving MCU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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