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Aliases for MCU Gene

Aliases for MCU Gene

  • Mitochondrial Calcium Uniporter 2 3
  • CCDC109A 3 4 6
  • Coiled-Coil Domain-Containing Protein 109A 3 4
  • C10orf42 3 4
  • Calcium Uniporter Protein, Mitochondrial 3
  • Coiled-Coil Domain Containing 109A 2

External Ids for MCU Gene

Previous HGNC Symbols for MCU Gene

  • C10orf42
  • CCDC109A

Previous GeneCards Identifiers for MCU Gene

  • GC10P074452

Summaries for MCU Gene

Entrez Gene Summary for MCU Gene

  • This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for MCU Gene

MCU (Mitochondrial Calcium Uniporter) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity and uniporter activity. An important paralog of this gene is CCDC109B.

UniProtKB/Swiss-Prot for MCU Gene

  • Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCU Gene

Genomics for MCU Gene

Genomic Location for MCU Gene

Start:
72,692,131 bp from pter
End:
72,887,694 bp from pter
Size:
195,564 bases
Orientation:
Plus strand

Genomic View for MCU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCU Gene

No data available for Regulatory Elements for MCU Gene

Proteins for MCU Gene

  • Protein details for MCU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE86-MCU_HUMAN
    Recommended name:
    Calcium uniporter protein, mitochondrial
    Protein Accession:
    Q8NE86
    Secondary Accessions:
    • B2RDF3
    • B3KXV7
    • Q96FL3

    Protein attributes for MCU Gene

    Size:
    351 amino acids
    Molecular mass:
    39867 Da
    Quaternary structure:
    • Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. Heterotetramer with CCDC109B/MCUB; this inhibits channel activity (By similarity). Homotetramer. Interacts with MICU1; MICU1 acts as an essential regulator for MCU. Interacts with MCUR1; interaction with MICU1 and MCUR1 are mutually exclusive.

    Alternative splice isoforms for MCU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCU Gene

Proteomics data for MCU Gene at MOPED

Post-translational modifications for MCU Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MCU Gene

Domains for MCU Gene

Protein Domains for MCU Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NE86

UniProtKB/Swiss-Prot:

MCU_HUMAN :
  • Q8NE86
Family:
  • Belongs to the MCU (TC 1.A.77) family.
genes like me logo Genes that share domains with MCU: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MCU Gene

Function for MCU Gene

Molecular function for MCU Gene

UniProtKB/Swiss-Prot Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.

Gene Ontology (GO) - Molecular Function for MCU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity IDA 21685888
GO:0005515 protein binding IPI 21685886
GO:0015292 uniporter activity IDA 21685886
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with MCU: view

Animal Model Products

miRNA for MCU Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCU Gene

Localization for MCU Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCU Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MCU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IDA 21685886
GO:0031305 integral component of mitochondrial inner membrane IDA 24231807
GO:0034704 calcium channel complex ISS --
GO:1990246 uniplex complex IDA 22925203
genes like me logo Genes that share ontologies with MCU: view

No data available for Subcellular locations from COMPARTMENTS for MCU Gene

Pathways for MCU Gene

SuperPathways for MCU Gene

No Data Available

Interacting Proteins for MCU Gene

Gene Ontology (GO) - Biological Process for MCU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006851 mitochondrial calcium ion transport IMP 21685886
GO:0019722 calcium-mediated signaling IDA 21685886
GO:0032024 positive regulation of insulin secretion IMP 22829870
GO:0035786 protein complex oligomerization IDA 21685886
GO:0036444 calcium ion transmembrane import into mitochondrion IDA 22925203
genes like me logo Genes that share ontologies with MCU: view

No data available for Pathways by source for MCU Gene

Transcripts for MCU Gene

Unigene Clusters for MCU Gene

Mitochondrial calcium uniporter:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCU

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCU Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - -
SP5:
SP6: - -
SP7: - -

Relevant External Links for MCU Gene

GeneLoc Exon Structure for
MCU
ECgene alternative splicing isoforms for
MCU

Expression for MCU Gene

mRNA expression in normal human tissues for MCU Gene

mRNA differential expression in normal tissues according to GTEx for MCU Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCU Gene

SOURCE GeneReport for Unigene cluster for MCU Gene Hs.591366

genes like me logo Genes that share expressions with MCU: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MCU Gene

Orthologs for MCU Gene

This gene was present in the common ancestor of animals.

Orthologs for MCU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCU 35
  • 99.34 (n)
  • 99.67 (a)
MCU 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCU 35
  • 95.25 (n)
  • 98.58 (a)
MCU 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCU 35
  • 94.88 (n)
  • 98.75 (a)
MCU 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcu 35
  • 88.19 (n)
  • 96.24 (a)
Mcu 16
Mcu 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCU 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCU 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcu 35
  • 88.4 (n)
  • 95.61 (a)
chicken
(Gallus gallus)
Aves MCU 35
  • 81.7 (n)
  • 89.59 (a)
MCU 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCU 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcu 35
  • 75.98 (n)
  • 80.32 (a)
zebrafish
(Danio rerio)
Actinopterygii mcu 35
  • 70.72 (n)
  • 78.82 (a)
mcu 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006330 35
  • 54.33 (n)
  • 54.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18769 35
  • 50.7 (n)
  • 46.6 (a)
CG18769 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mcu-1 35
  • 49.94 (n)
  • 43.22 (a)
mcu-1 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for MCU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCU Gene

ENSEMBL:
Gene Tree for MCU (if available)
TreeFam:
Gene Tree for MCU (if available)

Paralogs for MCU Gene

Paralogs for MCU Gene

Selected SIMAP similar genes for MCU Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MCU: view

Variants for MCU Gene

Sequence variations from dbSNP and Humsavar for MCU Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs720227 -- 72,756,960(+) TCGAA(A/C)TCAGG intron-variant
rs1010906 -- 72,733,717(-) TAAAT(G/T)TTCTT intron-variant
rs1010907 -- 72,733,699(-) AAata(A/T)atata intron-variant
rs1010908 -- 72,733,697(-) atata(A/T)atata intron-variant
rs1123641 -- 72,725,951(-) GGAAA(G/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCU Gene

Variant ID Type Subtype PubMed ID
nsv895722 CNV Loss 21882294
nsv895723 CNV Loss 21882294
dgv299e1 CNV Complex 17122850
nsv7121 CNV Insertion 18451855

Relevant External Links for MCU Gene

HapMap Linkage Disequilibrium report
MCU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCU Gene

Disorders for MCU Gene

No disorders were found for MCU Gene.

No data available for UniProtKB/Swiss-Prot for MCU Gene

Publications for MCU Gene

  1. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. (PMID: 21685888) De Stefani D. … Rizzuto R. (Nature 2011) 2 3 4
  2. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. (PMID: 21685886) Baughman J.M. … Mootha V.K. (Nature 2011) 2 3 4
  3. Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic beta-cells. (PMID: 22904319) Alam M.R. … Graier W.F. (J. Biol. Chem. 2012) 3 4
  4. The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic beta-cells. (PMID: 22829870) Tarasov A.I. … Rutter G.A. (PLoS ONE 2012) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MCU Gene

Sources for MCU Gene

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