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Aliases for MCTS1 Gene

Aliases for MCTS1 Gene

  • Malignant T Cell Amplified Sequence 1 2 3
  • MCT1 3 4 6
  • Multiple Copies T-Cell Malignancies 3 4
  • MCT-1 3 4
  • Malignant T-Cell-Amplified Sequence 1 3

External Ids for MCTS1 Gene

Previous GeneCards Identifiers for MCTS1 Gene

  • GC0XP118491
  • GC0XP119519
  • GC0XP119621
  • GC0XP119727
  • GC0XP109189

Summaries for MCTS1 Gene

GeneCards Summary for MCTS1 Gene

MCTS1 (Malignant T Cell Amplified Sequence 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for MCTS1 Gene

  • Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCTS1 Gene

Genomics for MCTS1 Gene

Regulatory Elements for MCTS1 Gene

Transcription factor binding sites by QIAGEN in the MCTS1 gene promoter:

Genomic Location for MCTS1 Gene

Start:
120,594,010 bp from pter
End:
120,621,159 bp from pter
Size:
27,150 bases
Orientation:
Plus strand

Genomic View for MCTS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCTS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCTS1 Gene

Proteins for MCTS1 Gene

  • Protein details for MCTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC4-MCTS1_HUMAN
    Recommended name:
    Malignant T-cell-amplified sequence 1
    Protein Accession:
    Q9ULC4
    Secondary Accessions:
    • B4DGY2
    • Q502X6

    Protein attributes for MCTS1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20555 Da
    Quaternary structure:
    • Interacts (via PUA domain) with DENR.

    Three dimensional structures from OCA and Proteopedia for MCTS1 Gene

    Alternative splice isoforms for MCTS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCTS1 Gene

Proteomics data for MCTS1 Gene at MOPED

Post-translational modifications for MCTS1 Gene

  • Phosphorylation is critical for stabilization and promotion of cell proliferation.
  • Ubiquitination at Lys87
  • Modification sites at PhosphoSitePlus

Other Protein References for MCTS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCTS1 Gene

Domains for MCTS1 Gene

Protein Domains for MCTS1 Gene

Suggested Antigen Peptide Sequences for MCTS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULC4

UniProtKB/Swiss-Prot:

MCTS1_HUMAN :
  • Q9ULC4
Domain:
  • The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.
  • Contains 1 PUA domain.
Family:
  • Belongs to the MCTS1 family.
genes like me logo Genes that share domains with MCTS1: view

No data available for Gene Families for MCTS1 Gene

Function for MCTS1 Gene

Molecular function for MCTS1 Gene

UniProtKB/Swiss-Prot Function: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
UniProtKB/Swiss-Prot Induction: By DNA damaging agents such as gamma irradiation, adriamycin or taxol in lymphoid cells, but not by stress stimuli such as heat shock. This induction of protein expression does not occur at the RNA level, and does not require new protein synthesis.

Gene Ontology (GO) - Molecular Function for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003743 translation initiation factor activity IEA --
genes like me logo Genes that share ontologies with MCTS1: view

Phenotypes for MCTS1 Gene

GenomeRNAi human phenotypes for MCTS1:
genes like me logo Genes that share phenotypes with MCTS1: view

Animal Model Products

CRISPR Products

miRNA for MCTS1 Gene

miRTarBase miRNAs that target MCTS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCTS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCTS1 Gene

Localization for MCTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCTS1 Gene

Cytoplasm. Note=Nuclear relocalization after DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCTS1 Gene COMPARTMENTS Subcellular localization image for MCTS1 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0022627 colocalizes_with cytosolic small ribosomal subunit IDA 20713520
genes like me logo Genes that share ontologies with MCTS1: view

Pathways for MCTS1 Gene

SuperPathways for MCTS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IDA 20713520
GO:0002192 IRES-dependent translational initiation IDA 20713520
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with MCTS1: view

No data available for Pathways by source for MCTS1 Gene

Transcripts for MCTS1 Gene

Unigene Clusters for MCTS1 Gene

Malignant T cell amplified sequence 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCTS1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MCTS1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCTS1 Gene

No ASD Table

Relevant External Links for MCTS1 Gene

GeneLoc Exon Structure for
MCTS1
ECgene alternative splicing isoforms for
MCTS1

Expression for MCTS1 Gene

mRNA expression in normal human tissues for MCTS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCTS1 Gene

SOURCE GeneReport for Unigene cluster for MCTS1 Gene Hs.102696

mRNA Expression by UniProt/SwissProt for MCTS1 Gene

Q9ULC4-MCTS1_HUMAN
Tissue specificity: Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
genes like me logo Genes that share expressions with MCTS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MCTS1 Gene

Orthologs for MCTS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCTS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCTS1 35
  • 100 (n)
  • 100 (a)
MCTS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCTS1 35
  • 96.5 (n)
  • 100 (a)
MCTS1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCTS1 35
  • 97.24 (n)
  • 100 (a)
MCTS1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcts1 35
  • 95.03 (n)
  • 99.45 (a)
Mcts1 16
Mcts1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCTS1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCTS1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcts1 35
  • 95.32 (n)
  • 98.88 (a)
chicken
(Gallus gallus)
Aves MCTS1 35
  • 87.11 (n)
  • 97.24 (a)
MCTS1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCTS1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcts1 35
  • 80.66 (n)
  • 96.69 (a)
Str.11037 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6712 35
zebrafish
(Danio rerio)
Actinopterygii mcts1 35
  • 79.93 (n)
  • 93.92 (a)
mcts1 36
  • 92 (a)
OneToOne
zgc56242 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003344 35
  • 58.15 (n)
  • 62.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5941 35
  • 57.83 (n)
  • 59.67 (a)
CG5941 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C11D2.7 35
  • 63.65 (n)
  • 64.41 (a)
C11D2.7 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR010C 35
  • 55.05 (n)
  • 51.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA20 35
  • 58.1 (n)
  • 49.14 (a)
TMA20 36
  • 45 (a)
OneToOne
TMA20 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13574g 35
  • 57.42 (n)
  • 49.13 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3319 35
barley
(Hordeum vulgare)
Liliopsida Hv.3374 35
rice
(Oryza sativa)
Liliopsida Os.18476 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08678 35
  • 43 (n)
  • 38.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC31F10.12 35
  • 53.45 (n)
  • 43.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for MCTS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCTS1 Gene

ENSEMBL:
Gene Tree for MCTS1 (if available)
TreeFam:
Gene Tree for MCTS1 (if available)

Paralogs for MCTS1 Gene

Pseudogenes.org Pseudogenes for MCTS1 Gene

genes like me logo Genes that share paralogs with MCTS1: view

No data available for Paralogs for MCTS1 Gene

Variants for MCTS1 Gene

Sequence variations from dbSNP and Humsavar for MCTS1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2233109 -- 120,603,259(+) gcctg(A/G)gcaac upstream-variant-2KB
rs2233110 - 120,608,279(+) TGTAC(A/T)CAGTG missense, reference
rs2233111 -- 120,610,960(+) GATGG(A/G)GAGGC intron-variant
rs2233112 -- 120,611,239(+) GCCAA(A/T)GAAAC intron-variant
rs2233113 -- 120,612,153(+) AAAAG(C/T)ATGTT intron-variant

Relevant External Links for MCTS1 Gene

HapMap Linkage Disequilibrium report
MCTS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCTS1 Gene

Disorders for MCTS1 Gene

No disorders were found for MCTS1 Gene.

No data available for UniProtKB/Swiss-Prot for MCTS1 Gene

Publications for MCTS1 Gene

  1. A novel candidate oncogene, MCT-1, is involved in cell cycle progression. (PMID: 9766643) Prosniak M. … Gartenhaus R.B. (Cancer Res. 1998) 2 3 4
  2. Expression and stabilization of the MCT-1 protein by DNA damaging agents. (PMID: 11709712) Herbert G.B. … Gartenhaus R.B. (Oncogene 2001) 3 4
  3. Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies. (PMID: 12637315) Shi B. … Gartenhaus R.B. (Blood 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin M.A. … Pestova T.V. (Genes Dev. 2010) 3 4

Products for MCTS1 Gene

  • Addgene plasmids for MCTS1

Sources for MCTS1 Gene

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