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MCTS1 Gene

protein-coding   GIFtS: 50
GCID: GC0XP119727

Malignant T Cell Amplified Sequence 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Malignant T Cell Amplified Sequence 11 2
MCT12 3 5
Multiple Copies T-Cell Malignancies2 3
MCT-12 3
Malignant T-Cell-Amplified Sequence 12

External Ids:    HGNC: 233571   Entrez Gene: 289852   Ensembl: ENSG000002321197   OMIM: 3005875   UniProtKB: Q9ULC43   

Export aliases for MCTS1 gene to outside databases

Previous GC identifers: GC0XP118491 GC0XP119519 GC0XP119621 GC0XP109189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MCTS1 Gene:
MCTS1 (malignant T cell amplified sequence 1) is a protein-coding gene. Diseases associated with MCTS1 include hodgkin's lymphoma, and non-hodgkin lymphoma. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: MCTS1_HUMAN, Q9ULC4
Function: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and
anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely
expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK
complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to
the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates
protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA
damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage
foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation
and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting
lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display
increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via
promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis.
Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer
cell; Positively regulates phosphorylation of MAPK1 and MAPK3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MCTS1 gene promoter:
         Sp1   p53   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCTS1 promoter sequence
   Search Chromatin IP Primers for MCTS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCTS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

MCTS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCTS1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP119727:  view genomic region     (about GC identifiers)

Start:
119,727,865 bp from pter      End:
119,755,014 bp from pter
Size:
27,150 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCTS1_HUMAN, Q9ULC4 (See protein sequence)
Recommended Name: Malignant T-cell-amplified sequence 1  
Size: 181 amino acids; 20555 Da
Subunit: Interacts (via PUA domain) with DENR
1 PDB 3D structure from and Proteopedia for MCTS1:
3R90 (3D)    
Secondary accessions: B4DGY2 Q502X6
Alternative splicing: 3 isoforms:  Q9ULC4-1   Q9ULC4-2   Q9ULC4-3   

Explore the universe of human proteins at neXtProt for MCTS1: NX_Q9ULC4

Explore proteomics data for MCTS1 at MOPED

Post-translational modifications: 

  • Phosphorylation is critical for stabilization and promotion of cell proliferation1
  • Ubiquitination2 at Lys87
  • Modification sites at PhosphoSitePlus

  • See MCTS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001131026.1  NP_054779.1  

    ENSEMBL proteins: 
     ENSP00000360367   ENSP00000360365  

    MCTS1 Human Recombinant Protein Products:

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    MCTS1 Assay Products:

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    Cloud-Clone Corp. ELISAs for MCTS1
    Cloud-Clone Corp. CLIAs for MCTS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016437 Transl_RNA-bd_prd
     IPR004521 Uncharacterised_CHP00451
     IPR015947 PUA-like_domain
     IPR002478 PUA

    Graphical View of Domain Structure for InterPro Entry Q9ULC4

    ProtoNet protein and cluster: Q9ULC4

    UniProtKB/Swiss-Prot: MCTS1_HUMAN, Q9ULC4
    Domain: The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer
    function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other
    proteins
    Similarity: Belongs to the MCTS1 family
    Similarity: Contains 1 PUA domain


    MCTS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCTS1_HUMAN, Q9ULC4
    Function: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and
    anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely
    expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK
    complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to
    the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates
    protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA
    damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage
    foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation
    and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting
    lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display
    increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via
    promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis.
    Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer
    cell; Positively regulates phosphorylation of MAPK1 and MAPK3
    Induction: By DNA damaging agents such as gamma irradiation, adriamycin or taxol in lymphoid cells, but not by
    stress stimuli such as heat shock. This induction of protein expression does not occur at the RNA level, and does
    not require new protein synthesis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
         
    MCTS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MCTS1:
     Increased 8N DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MCTS1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCTS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCTS1

    miRNA
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    miRTarBase miRNAs that target MCTS1:
    hsa-mir-652-3p (MIRT039499)

    Block miRNA regulation of human, mouse, rat MCTS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCTS1 (see all 108):
    hsa-miR-549 hsa-miR-642a hsa-miR-607 hsa-miR-3194-5p hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidMCTS1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MCTS1

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    GenScript: all cDNA clones in your preferred vector (see all 2): MCTS1 (NM_014060)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCTS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCTS1_HUMAN, Q9ULC4: Cytoplasm. Note=Nuclear relocalization after DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    MCTS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MCTS1
    Interactions:

        Search GeneGlobe Interaction Network for MCTS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for MCTS1 (Q9ULC42, 3 ENSP000003603654) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DENRO435832, 3, ENSP000002805574MINT-65757 I2D: score=11 STRING: ENSP00000280557
    MRPL22Q9NWU53, ENSP000004111774I2D: score=5 STRING: ENSP00000411177
    RPL37P619273, ENSP000002742424I2D: score=1 STRING: ENSP00000274242
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006974cellular response to DNA damage stimulus IEA--
    GO:0007049cell cycle IEA--
    GO:0008284positive regulation of cell proliferation TAS9766643

    MCTS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MCTS1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MCTS1 gene (2 alternative transcripts): 
    NM_001137554.1  NM_014060.2  

    Unigene Cluster for MCTS1:

    Malignant T cell amplified sequence 1
    Hs.102696  [show with all ESTs]
    Unigene Representative Sequence: NM_014060
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493879 ENST00000493274 ENST00000371317(uc004esx.3) ENST00000371315(uc011mub.2)
    ENST00000487133(uc022cdn.1) ENST00000484481 ENST00000424799
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MCTS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCTS1 (see all 108):
    hsa-miR-549 hsa-miR-642a hsa-miR-607 hsa-miR-3194-5p hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidMCTS1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat MCTS1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MCTS1 (NM_014060)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCTS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCTS1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCTS1
      QuantiTect SYBR Green Assays in human, mouse, rat MCTS1
      QuantiFast Probe-based Assays in human, mouse, rat MCTS1

    Additional mRNA sequence: 

    AB034206.1 AK096956.1 AK294834.1 AK311993.1 AY364258.1 BC001013.2 BC095461.1 

    17 DOTS entries:

    DT.417400  DT.121311096  DT.40296651  DT.97855432  DT.121310995  DT.95195921  DT.200839  DT.417401 
    DT.91727085  DT.99998978  DT.100793130  DT.101980801  DT.121311120  DT.121311141  DT.95086537  DT.100026970 
    DT.40296765 

    Selected AceView cDNA sequences (see all 217):

    AA633371 BU624528 BX282354 BU675438 CA310435 AJ708833 AA918864 AA553782 
    AA670154 BF794745 AA554905 BC001013 AI281293 AA383310 CB110477 BQ010236 
    AA952898 AA503091 BG029651 BM787109 BI858586 BM453076 BF477790 BI335873 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MCTS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATAATGC
    MCTS1 Expression
    About this image

    MCTS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCTS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.102696

    UniProtKB/Swiss-Prot: MCTS1_HUMAN, Q9ULC4
    Tissue specificity: Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell
    lines as well as in a subset of primary large B-cell lymphomas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCTS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCTS1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcts11 , 5 malignant T cell amplified sequence 11, 5 95.03(n)1
    99.45(a)1
      X (22.88 cM)5
    689951  NM_026902.31  NP_081178.11 
     386005785 
    chicken
    (Gallus gallus)
    Aves MCTS11 malignant T cell amplified sequence 1 87.11(n)
    97.24(a)
      422363  NM_001105675.1  NP_001099145.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCTS16
    malignant T cell amplified sequence 1
    96(a)
    1 ↔ 1
    GL343839.1(33350-42398)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ074165.12   -- 81.62(n)    BJ074165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562422 similar to MCT-1 protein 82.5(n)   394046  BC046019.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59411 CG5941 57.83(n)
    59.67(a)
      31536  NM_132060.3  NP_572288.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C11D2.71 C11D2.7 63.65(n)
    64.41(a)
      177377  NM_171351.3  NP_741412.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMA20(YER007C-A)4
    TMA201
    Protein of unknown function that associates with ribosomes more4
    TMA201
    58.1(n)1
    49.14(a)1
      5(166885-166237)4
    8567251, 4  NP_010923.31  NP_010923.14 
    soybean
    (Glycine max)
    eudicotyledons AW351283.12   -- 72.68(n)    AW351283.1 
    rice
    (Oryza sativa)
    Liliopsida Os.184762 Oryza sativa (japonica cultivar-group) cDNA clone0 more 79.58(n)    AK073419.1 


    ENSEMBL Gene Tree for MCTS1 (if available)
    TreeFam Gene Tree for MCTS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MCTS1 gene

    MCTS1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MCTS1
    PGOHUM00000247641


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCTS1 (see all 242)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909607771,2
    --119735858(+) AGAATA/GAACTA 1 -- us2k10--------
    rs59097331,2
    C,F,A,H--119736094(+) TGGCAC/GTCACC 1 -- us2k116Minor allele frequency- G:0.41NS EA NA WA CSA 644
    rs1827957071,2
    --119736433(+) GGCCCA/GTCTCC 1 -- us2k10--------
    rs1409947791,2
    --119736474(+) GGAGAC/GTGGTG 1 -- us2k10--------
    rs1873546431,2
    --119736551(+) TTTTTC/TCATGA 1 -- us2k10--------
    rs66456591,2
    C,H--119736587(+) TTAggC/Tcaggc 2 -- us2k17Minor allele frequency- T:0.00NS EA NA 582
    rs1829390971,2
    --119736624(+) CACTTC/TGGGAG 2 -- us2k10--------
    rs606690901,2
    C,F--119736625(+) ACTTCA/GGGAGG 2 -- us2k11Minor allele frequency- G:0.00WA 2
    rs1872389591,2
    --119736645(+) GGGAAC/TTGCTC 2 -- us2k10--------
    rs1916977271,2
    --119736723(+) AATTCA/GCCAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MCTS1 (119727865 - 119755014 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MCTS1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MCTS1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300587    OMIM disorders: --

    7 diseases for MCTS1:    
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    hodgkin's lymphoma    non-hodgkin lymphoma    b-cell lymphomas    malaria
    ovarian cancer    breast cancer    melanoma


    MCTS1 for disorders           About GeneDecksing


    Export disorders for MCTS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MCTS1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MCTS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel candidate oncogene, MCT-1, is involved in cell cycle progression. (PubMed id 9766643)1, 2, 3 Prosniak M....Gartenhaus R.B. (Cancer Res. 1998)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies. (PubMed id 12637315)1, 2 Shi B.... Gartenhaus R.B. (Blood 2003)
    4. Expression and stabilization of the MCT-1 protein by DNA damaging agents. (PubMed id 11709712)1, 2 Herbert G.B.... Gartenhaus R.B. (Oncogene 2001)
    5. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. (PubMed id 23258846)1 Miranda-GonAsalves V....Baltazar F. (Neuro-oncology 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities. (PubMed id 22336915)1 Shih H.J....Hsu H.L. (Cell Cycle 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28985 HGNC: 23357 AceView: MCTS1 Ensembl:ENSG00000232119 euGenes: HUgn28985
    ECgene: MCTS1 H-InvDB: MCTS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MCTS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCTS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MCTS1 gene:
    Search GeneIP for patents involving MCTS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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