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Aliases for MCTS1 Gene

Aliases for MCTS1 Gene

  • Malignant T-Cell Amplified Sequence 1 2 3 5
  • Multiple Copies T-Cell Malignancies 3 4
  • MCT-1 3 4
  • MCT1 3 4
  • Malignant T Cell Amplified Sequence 1 3

External Ids for MCTS1 Gene

Previous GeneCards Identifiers for MCTS1 Gene

  • GC0XP118491
  • GC0XP119519
  • GC0XP119621
  • GC0XP119727
  • GC0XP109189

Summaries for MCTS1 Gene

GeneCards Summary for MCTS1 Gene

MCTS1 (Malignant T-Cell Amplified Sequence 1) is a Protein Coding gene. Diseases associated with MCTS1 include erythrocyte lactate transporter defect and hyperinsulinemic hypoglycemia, familial, 7. GO annotations related to this gene include RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for MCTS1 Gene

  • Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCTS1 Gene

Genomics for MCTS1 Gene

Regulatory Elements for MCTS1 Gene

Transcription factor binding sites by QIAGEN in the MCTS1 gene promoter:

Genomic Location for MCTS1 Gene

Chromosome:
X
Start:
120,594,010 bp from pter
End:
120,621,159 bp from pter
Size:
27,150 bases
Orientation:
Plus strand

Genomic View for MCTS1 Gene

Genes around MCTS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCTS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCTS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCTS1 Gene

Proteins for MCTS1 Gene

  • Protein details for MCTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC4-MCTS1_HUMAN
    Recommended name:
    Malignant T-cell-amplified sequence 1
    Protein Accession:
    Q9ULC4
    Secondary Accessions:
    • B4DGY2
    • Q502X6

    Protein attributes for MCTS1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20555 Da
    Quaternary structure:
    • Interacts (via PUA domain) with DENR.

    Three dimensional structures from OCA and Proteopedia for MCTS1 Gene

    Alternative splice isoforms for MCTS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCTS1 Gene

Proteomics data for MCTS1 Gene at MOPED

Post-translational modifications for MCTS1 Gene

  • Phosphorylation is critical for stabilization and promotion of cell proliferation.
  • Ubiquitination at Lys 87
  • Modification sites at PhosphoSitePlus

Other Protein References for MCTS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MCTS1 Gene

Domains & Families for MCTS1 Gene

Protein Domains for MCTS1 Gene

Suggested Antigen Peptide Sequences for MCTS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULC4

UniProtKB/Swiss-Prot:

MCTS1_HUMAN :
  • The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.
  • Belongs to the MCTS1 family.
Domain:
  • The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.
  • Contains 1 PUA domain.
Family:
  • Belongs to the MCTS1 family.
genes like me logo Genes that share domains with MCTS1: view

No data available for Gene Families for MCTS1 Gene

Function for MCTS1 Gene

Molecular function for MCTS1 Gene

UniProtKB/Swiss-Prot Function:
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
UniProtKB/Swiss-Prot Induction:
By DNA damaging agents such as gamma irradiation, adriamycin or taxol in lymphoid cells, but not by stress stimuli such as heat shock. This induction of protein expression does not occur at the RNA level, and does not require new protein synthesis.
genes like me logo Genes that share phenotypes with MCTS1: view

Animal Model Products

miRNA for MCTS1 Gene

miRTarBase miRNAs that target MCTS1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCTS1 Gene

Localization for MCTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCTS1 Gene

Cytoplasm. Note=Nuclear relocalization after DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCTS1 Gene COMPARTMENTS Subcellular localization image for MCTS1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MCTS1: view

Pathways & Interactions for MCTS1 Gene

SuperPathways for MCTS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002192 IRES-dependent translational initiation IDA 20713520
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with MCTS1: view

No data available for Pathways by source and SIGNOR curated interactions for MCTS1 Gene

Drugs & Compounds for MCTS1 Gene

No Compound Related Data Available

Transcripts for MCTS1 Gene

Unigene Clusters for MCTS1 Gene

Malignant T cell amplified sequence 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCTS1 Gene

No ASD Table

Relevant External Links for MCTS1 Gene

GeneLoc Exon Structure for
MCTS1
ECgene alternative splicing isoforms for
MCTS1

Expression for MCTS1 Gene

mRNA expression in normal human tissues for MCTS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCTS1 Gene

This gene is overexpressed in Skin (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCTS1 Gene



SOURCE GeneReport for Unigene cluster for MCTS1 Gene Hs.102696

mRNA Expression by UniProt/SwissProt for MCTS1 Gene

Q9ULC4-MCTS1_HUMAN
Tissue specificity: Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
genes like me logo Genes that share expression patterns with MCTS1: view

Protein tissue co-expression partners for MCTS1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MCTS1 Gene

Orthologs for MCTS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCTS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCTS1 35
  • 96.5 (n)
  • 100 (a)
MCTS1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCTS1 35
  • 97.24 (n)
  • 100 (a)
MCTS1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcts1 35
  • 95.03 (n)
  • 99.45 (a)
Mcts1 16
Mcts1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCTS1 35
  • 100 (n)
  • 100 (a)
MCTS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcts1 35
  • 95.32 (n)
  • 98.88 (a)
oppossum
(Monodelphis domestica)
Mammalia MCTS1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCTS1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCTS1 35
  • 87.11 (n)
  • 97.24 (a)
MCTS1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCTS1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcts1 35
  • 80.66 (n)
  • 96.69 (a)
Str.11037 35
zebrafish
(Danio rerio)
Actinopterygii mcts1 35
  • 79.93 (n)
  • 93.92 (a)
zgc56242 35
mcts1 36
  • 92 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6712 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003344 35
  • 58.15 (n)
  • 62.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5941 35
  • 57.83 (n)
  • 59.67 (a)
CG5941 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C11D2.7 35
  • 63.65 (n)
  • 64.41 (a)
C11D2.7 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR010C 35
  • 55.05 (n)
  • 51.43 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13574g 35
  • 57.42 (n)
  • 49.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA20 35
  • 58.1 (n)
  • 49.14 (a)
TMA20 36
  • 45 (a)
OneToOne
TMA20 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3319 35
barley
(Hordeum vulgare)
Liliopsida Hv.3374 35
rice
(Oryza sativa)
Liliopsida Os.18476 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08678 35
  • 43 (n)
  • 38.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC31F10.12 35
  • 53.45 (n)
  • 43.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for MCTS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCTS1 Gene

ENSEMBL:
Gene Tree for MCTS1 (if available)
TreeFam:
Gene Tree for MCTS1 (if available)

Paralogs for MCTS1 Gene

Pseudogenes.org Pseudogenes for MCTS1 Gene

genes like me logo Genes that share paralogs with MCTS1: view

No data available for Paralogs for MCTS1 Gene

Variants for MCTS1 Gene

Sequence variations from dbSNP and Humsavar for MCTS1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2233110 - 120,608,279(+) TGTAC(A/T)CAGTG nc-transcript-variant, reference, missense
rs2233109 -- 120,603,259(+) gcctg(A/G)gcaac upstream-variant-2KB
rs2233111 -- 120,610,960(+) GATGG(A/G)GAGGC intron-variant
rs2233112 -- 120,611,239(+) GCCAA(A/T)GAAAC intron-variant
rs2233113 -- 120,612,153(+) AAAAG(C/T)ATGTT intron-variant

Variation tolerance for MCTS1 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCTS1 Gene

HapMap Linkage Disequilibrium report
MCTS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCTS1 Gene

Disorders for MCTS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MCTS1 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
erythrocyte lactate transporter defect
  • symptomatic deficiency in lactate transport
hyperinsulinemic hypoglycemia, familial, 7
  • exercise-induced hyperinsulinemic hypoglycemia
monocarboxylate transporter 1 deficiency
  • mct1d
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search MCTS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCTS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCTS1
genes like me logo Genes that share disorders with MCTS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCTS1 Gene

Publications for MCTS1 Gene

  1. A novel candidate oncogene, MCT-1, is involved in cell cycle progression. (PMID: 9766643) Prosniak M. … Gartenhaus R.B. (Cancer Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. (PMID: 23258846) Miranda-GonAsalves V. … Baltazar F. (Neuro-oncology 2013) 3
  5. The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities. (PMID: 22336915) Shih H.J. … Hsu H.L. (Cell Cycle 2012) 3

Products for MCTS1 Gene

Sources for MCTS1 Gene

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