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Aliases for MCTP2 Gene

Aliases for MCTP2 Gene

  • Multiple C2 Domains, Transmembrane 2 2 3

External Ids for MCTP2 Gene

Previous GeneCards Identifiers for MCTP2 Gene

  • GC15P092575
  • GC15P092642
  • GC15P094774
  • GC15P070976

Summaries for MCTP2 Gene

GeneCards Summary for MCTP2 Gene

MCTP2 (Multiple C2 Domains, Transmembrane 2) is a Protein Coding gene. Diseases associated with MCTP2 include distal monosomy 15q. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is MCTP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCTP2 Gene

Genomics for MCTP2 Gene

Regulatory Elements for MCTP2 Gene

Genomic Location for MCTP2 Gene

94,231,538 bp from pter
94,483,952 bp from pter
252,415 bases
Plus strand

Genomic View for MCTP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCTP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCTP2 Gene

Proteins for MCTP2 Gene

  • Protein details for MCTP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multiple C2 and transmembrane domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A2RRC2
    • C6G483
    • C6G484
    • Q49AB0
    • Q8TAX2
    • Q9NUS2
    • Q9NUW7

    Protein attributes for MCTP2 Gene

    878 amino acids
    Molecular mass:
    99596 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds Ca(2+) via the C2 domains in absence of phospholipids.;
    Quaternary structure:
    No Data Available
    • Sequence=AAH41387.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA91998.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MCTP2 Gene

    Alternative splice isoforms for MCTP2 Gene


neXtProt entry for MCTP2 Gene

Proteomics data for MCTP2 Gene at MOPED

Post-translational modifications for MCTP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCTP2 Gene

No data available for DME Specific Peptides for MCTP2 Gene

Domains for MCTP2 Gene

Gene Families for MCTP2 Gene

Protein Domains for MCTP2 Gene


Suggested Antigen Peptide Sequences for MCTP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 C2 domains.
  • Belongs to the MCTP family.
  • Contains 3 C2 domains.
  • Belongs to the MCTP family.
genes like me logo Genes that share domains with MCTP2: view

Function for MCTP2 Gene

Gene Ontology (GO) - Molecular Function for MCTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15528213
GO:0005515 protein binding --
GO:0005544 NOT calcium-dependent phospholipid binding IDA 15528213
genes like me logo Genes that share ontologies with MCTP2: view

Animal Model Products

miRNA for MCTP2 Gene

miRTarBase miRNAs that target MCTP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCTP2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCTP2 Gene

Localization for MCTP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCTP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MCTP2 Gene COMPARTMENTS Subcellular localization image for MCTP2 gene
Compartment Confidence
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MCTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IDA 15528213
genes like me logo Genes that share ontologies with MCTP2: view

Pathways for MCTP2 Gene

SuperPathways for MCTP2 Gene

No Data Available

Interacting Proteins for MCTP2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350377 Q6DN12-MCTP2_HUMAN for MCTP2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MCTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019722 calcium-mediated signaling NAS 15528213
genes like me logo Genes that share ontologies with MCTP2: view

No data available for Pathways by source for MCTP2 Gene

Compounds for MCTP2 Gene

(1) HMDB Compounds for MCTP2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with MCTP2: view

Transcripts for MCTP2 Gene

Unigene Clusters for MCTP2 Gene

Multiple C2 domains, transmembrane 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCTP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCTP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
SP1: - -
SP2: - -

Relevant External Links for MCTP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MCTP2 Gene

mRNA expression in normal human tissues for MCTP2 Gene

mRNA differential expression in normal tissues according to GTEx for MCTP2 Gene

This gene is overexpressed in Whole Blood (18.4).

Protein differential expression in normal tissues for MCTP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.0), CD8 Tcells (17.2), Blymphocyte (12.7), and Platelet (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCTP2 Gene

SOURCE GeneReport for Unigene cluster for MCTP2 Gene Hs.33368

genes like me logo Genes that share expressions with MCTP2: view

Expression partners for MCTP2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MCTP2 Gene

Orthologs for MCTP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCTP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MCTP2 35
  • 89.02 (n)
  • 90.65 (a)
MCTP2 36
  • 90 (a)
(Canis familiaris)
Mammalia MCTP2 35
  • 91.31 (n)
  • 92.82 (a)
MCTP2 36
  • 93 (a)
(Mus musculus)
Mammalia Mctp2 35
  • 85.88 (n)
  • 89.29 (a)
Mctp2 16
Mctp2 36
  • 89 (a)
(Pan troglodytes)
Mammalia MCTP2 35
  • 98.37 (n)
  • 98.06 (a)
MCTP2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mctp2 35
  • 85.21 (n)
  • 89.22 (a)
(Monodelphis domestica)
Mammalia MCTP2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia MCTP2 36
  • 82 (a)
(Gallus gallus)
Aves LOC426324 35
  • 72.44 (n)
  • 71.27 (a)
MCTP2 36
  • 70 (a)
(Anolis carolinensis)
Reptilia MCTP2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mctp2 35
  • 66.82 (n)
  • 65.06 (a)
(Danio rerio)
Actinopterygii mctp2a 35
  • 58.86 (n)
  • 52.86 (a)
mctp2a 36
  • 45 (a)
mctp2b 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mctp 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea D2092.1 36
  • 32 (a)
(Oryza sativa)
Liliopsida Os04g0691800 35
  • 37.31 (n)
  • 25.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9926 36
  • 37 (a)
Species with no ortholog for MCTP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCTP2 Gene

Gene Tree for MCTP2 (if available)
Gene Tree for MCTP2 (if available)

Paralogs for MCTP2 Gene

Paralogs for MCTP2 Gene

(2) SIMAP similar genes for MCTP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MCTP2: view

Variants for MCTP2 Gene

Sequence variations from dbSNP and Humsavar for MCTP2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs184151 -- 94,310,643(-) ttttt(A/G)taGAG intron-variant
rs186056 -- 94,457,108(-) TAGAA(G/T)TTTAG intron-variant
rs189755 -- 94,471,737(-) ATCAG(G/T)GGCCC intron-variant
rs293574 -- 94,455,478(-) cctgg(C/T)gacag intron-variant
rs293575 -- 94,455,255(-) taaga(C/G)aatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCTP2 Gene

Variant ID Type Subtype PubMed ID
nsv904517 CNV Gain 21882294
nsv904518 CNV Gain 21882294
nsv833097 CNV Gain 17160897
nsv519193 CNV Loss 19592680
nsv904521 CNV Gain 21882294
nsv820715 CNV Duplication 20802225
dgv447n67 CNV Loss 20364138
nsv827440 CNV Gain+Loss 20364138
esv22514 CNV Loss 19812545
nsv513437 CNV Insertion 21212237
esv2474634 CNV Insertion 19546169
nsv520668 CNV Loss 19592680
nsv904522 CNV Loss 21882294
esv2750070 CNV Deletion 23290073
esv2750071 CNV Deletion 23290073
esv1007834 CNV Deletion 20482838
esv1647697 CNV Deletion 17803354

Relevant External Links for MCTP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCTP2 Gene

Disorders for MCTP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MCTP2 Gene in MalaCards »

(1) Disease for MCTP2 Gene

Relevant External Links for MCTP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MCTP2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MCTP2 Gene

Publications for MCTP2 Gene

  1. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. (PMID: 15528213) Shin O.H. … Sudhof T.C. (J. Biol. Chem. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PMID: 18367154) Verma R. … Levinson D.F. (Biol. Psychiatry 2008) 3 48
  4. Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE). (PMID: 19223264) Djurovic S. … Andreassen O.A. (Psychiatry Res 2009) 3 48
  5. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (PMID: 19483685) Daly A.K. … . (Nat. Genet. 2009) 3 48

Products for MCTP2 Gene

Sources for MCTP2 Gene

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