Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MCRS1 Gene

Aliases for MCRS1 Gene

  • Microspherule Protein 1 2 3 5
  • Cell Cycle-Regulated Factor P78 3 4
  • 58 KDa Microspherule Protein 3 4
  • INO80 Complex Subunit Q 2 3
  • INO80 Complex Subunit J 3 4
  • INO80Q 3 4
  • MCRS2 3 4
  • MSP58 3 4
  • Cell Cycle-Regulated Factor (78 KDa) 3
  • ICP22BP 3
  • P78 3

External Ids for MCRS1 Gene

Previous GeneCards Identifiers for MCRS1 Gene

  • GC12M050169
  • GC12M050008
  • GC12M049668
  • GC12M048238
  • GC12M049952
  • GC12M046982

Summaries for MCRS1 Gene

GeneCards Summary for MCRS1 Gene

MCRS1 (Microspherule Protein 1) is a Protein Coding gene. Diseases associated with MCRS1 include herpes simplex and pigmented basal cell carcinoma. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).

UniProtKB/Swiss-Prot for MCRS1 Gene

  • Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.

Gene Wiki entry for MCRS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCRS1 Gene

Genomics for MCRS1 Gene

Regulatory Elements for MCRS1 Gene

Promoters for MCRS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MCRS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCRS1 Gene

Chromosome:
12
Start:
49,556,544 bp from pter
End:
49,568,225 bp from pter
Size:
11,682 bases
Orientation:
Minus strand

Genomic View for MCRS1 Gene

Genes around MCRS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCRS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCRS1 Gene

Proteins for MCRS1 Gene

  • Protein details for MCRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EZ8-MCRS1_HUMAN
    Recommended name:
    Microspherule protein 1
    Protein Accession:
    Q96EZ8
    Secondary Accessions:
    • O14742
    • O75497
    • Q6VN53
    • Q7Z372

    Protein attributes for MCRS1 Gene

    Size:
    462 amino acids
    Molecular mass:
    51803 Da
    Quaternary structure:
    • Binds to NOP2, DAXX, PINX1, TERT and Herpes simplex virus ICP22. Interacts with CCDC85B. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
    SequenceCaution:
    • Sequence=AAC68599.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MCRS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCRS1 Gene

Proteomics data for MCRS1 Gene at MOPED

Post-translational modifications for MCRS1 Gene

  • Ubiquitination at Lys 186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MCRS1 Gene

Domains & Families for MCRS1 Gene

Gene Families for MCRS1 Gene

Protein Domains for MCRS1 Gene

Suggested Antigen Peptide Sequences for MCRS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EZ8

UniProtKB/Swiss-Prot:

MCRS1_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with MCRS1: view

Function for MCRS1 Gene

Molecular function for MCRS1 Gene

GENATLAS Biochemistry:
microspherule protein 1,nucleolar,associated with the proliferation-related nucleolar protein which is detectable early in the G1 phase of the cell cycle and peaks early in the S phase,potentially affecting the size and shape of the nucleolus
UniProtKB/Swiss-Prot Function:
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.

Gene Ontology (GO) - Molecular Function for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008266 poly(U) RNA binding IDA 16571602
genes like me logo Genes that share ontologies with MCRS1: view
genes like me logo Genes that share phenotypes with MCRS1: view

Animal Models for MCRS1 Gene

MGI Knock Outs for MCRS1:

Animal Model Products

miRNA for MCRS1 Gene

miRTarBase miRNAs that target MCRS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCRS1 Gene

Localization for MCRS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCRS1 Gene

Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCRS1 Gene COMPARTMENTS Subcellular localization image for MCRS1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005730 nucleolus IEA,IDA 16571602
GO:0005737 cytoplasm IDA 16571602
GO:0005844 polysome ISS --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with MCRS1: view

Pathways & Interactions for MCRS1 Gene

genes like me logo Genes that share pathways with MCRS1: view

Gene Ontology (GO) - Biological Process for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043981 histone H4-K5 acetylation IDA 20018852
GO:0043982 histone H4-K8 acetylation IDA 20018852
genes like me logo Genes that share ontologies with MCRS1: view

No data available for SIGNOR curated interactions for MCRS1 Gene

Drugs & Compounds for MCRS1 Gene

(4) Drugs for MCRS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MCRS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MCRS1: view

Transcripts for MCRS1 Gene

Unigene Clusters for MCRS1 Gene

Microspherule protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCRS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - -
SP2: - -
SP3: -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6:
SP7: - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -
SP11: - - - -
SP12: - - - - -

ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c · 17d
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MCRS1 Gene

GeneLoc Exon Structure for
MCRS1
ECgene alternative splicing isoforms for
MCRS1

Expression for MCRS1 Gene

mRNA expression in normal human tissues for MCRS1 Gene

Protein differential expression in normal tissues from HIPED for MCRS1 Gene

This gene is overexpressed in Blymphocyte (25.9), Peripheral blood mononuclear cells (13.9), Placenta (13.2), and CD8 Tcells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCRS1 Gene



SOURCE GeneReport for Unigene cluster for MCRS1 Gene Hs.25313

mRNA Expression by UniProt/SwissProt for MCRS1 Gene

Q96EZ8-MCRS1_HUMAN
Tissue specificity: Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
genes like me logo Genes that share expression patterns with MCRS1: view

Protein tissue co-expression partners for MCRS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MCRS1 Gene

Orthologs for MCRS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCRS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCRS1 35
  • 93.17 (n)
  • 99.35 (a)
MCRS1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCRS1 35
  • 93.26 (n)
  • 98.95 (a)
MCRS1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcrs1 35
  • 91.43 (n)
  • 98.26 (a)
Mcrs1 16
Mcrs1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCRS1 35
  • 99.79 (n)
  • 100 (a)
MCRS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcrs1 35
  • 91.29 (n)
  • 98.47 (a)
oppossum
(Monodelphis domestica)
Mammalia MCRS1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCRS1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCRS1 35
  • 81.16 (n)
  • 86.72 (a)
MCRS1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mcrs1 35
  • 73.39 (n)
  • 85.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia mcrs1-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.23962 35
mcrs1 35
  • 71.34 (n)
  • 77.95 (a)
mcrs1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1135 37
  • 58 (a)
Rcd5 35
  • 60.74 (n)
  • 60.24 (a)
Rcd5 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005560 35
  • 65.5 (n)
  • 63.37 (a)
worm
(Caenorhabditis elegans)
Secernentea mcrs-1 36
  • 24 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8684 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToOne
Species with no ortholog for MCRS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCRS1 Gene

ENSEMBL:
Gene Tree for MCRS1 (if available)
TreeFam:
Gene Tree for MCRS1 (if available)

Paralogs for MCRS1 Gene

(1) SIMAP similar genes for MCRS1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with MCRS1: view

No data available for Paralogs for MCRS1 Gene

Variants for MCRS1 Gene

Sequence variations from dbSNP and Humsavar for MCRS1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035473 A colorectal cancer sample
rs13066 -- 49,566,768(-) AGCCC(A/G/T)GTGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1248365 -- 49,568,784(-) TCCCA(C/T)CCCAA upstream-variant-2KB
rs2303305 -- 49,558,885(-) GTGCT(C/T)TGTGG reference, synonymous-codon
rs2288077 -- 49,560,065(-) CTTCC(A/G)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCRS1 Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV Loss 17160897
nsv899071 CNV Loss 21882294

Variation tolerance for MCRS1 Gene

Residual Variation Intolerance Score: 7.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCRS1 Gene

HapMap Linkage Disequilibrium report
MCRS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCRS1 Gene

Disorders for MCRS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MCRS1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
pigmented basal cell carcinoma
  • skin pigmented basal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MCRS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCRS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCRS1
genes like me logo Genes that share disorders with MCRS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCRS1 Gene

Publications for MCRS1 Gene

  1. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. (PMID: 9654073) Ren Y. … Busch H. (Eur. J. Biochem. 1998) 2 3 4 23 67
  2. MCRS2 represses the transactivation activities of Nrf1. (PMID: 19187526) Wu J.L. … Huang C.F. (BMC Cell Biol. 2009) 3 23
  3. Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway. (PMID: 19549253) Shi H. … Fan D. (Cancer Sci. 2009) 3 23
  4. p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability. (PMID: 16547491) Hirohashi Y. … Greene M.I. (Oncogene 2006) 3 23
  5. Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. (PMID: 15044100) Song H. … Zhao M. (Biochem. Biophys. Res. Commun. 2004) 3 23

Products for MCRS1 Gene

Sources for MCRS1 Gene

Back to Top

Content