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MCRS1 Gene

protein-coding   GIFtS: 61
GCID: GC12M049952

Microspherule Protein 1

  See MCRS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microspherule Protein 11 2     MSP582 3
INO80 Complex Subunit Q1 2     INO80 Complex Subunit J2 3
Cell Cycle-Regulated Factor P782 3     ICP22BP2
58 KDa Microspherule Protein2 3     P782
INO80Q2 3     Cell Cycle-Regulated Factor (78 KDa)2
MCRS22 3     

External Ids:    HGNC: 69601   Entrez Gene: 104452   Ensembl: ENSG000001877787   OMIM: 6095045   UniProtKB: Q96EZ83   

Export aliases for MCRS1 gene to outside databases

Previous GC identifers: GC12M050169 GC12M050008 GC12M049668 GC12M048238 GC12M046982


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MCRS1 Gene:
MCRS1 (microspherule protein 1) is a protein-coding gene. Diseases associated with MCRS1 include pigmented basal cell carcinoma, and ampulla of vater carcinoma. GO annotations related to this gene include histone acetyltransferase activity (H4-K16 specific) and histone acetyltransferase activity (H4-K5 specific).

UniProtKB/Swiss-Prot: MCRS1_HUMAN, Q96EZ8
Function: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the
NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative
regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation,
DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity

Gene Wiki entry for MCRS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MCRS1 gene promoter:
         E2F   E2F-1   E2F-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MCRS1 promoter sequence
   Search Chromatin IP Primers for MCRS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCRS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

MCRS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCRS1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049952:  view genomic region     (about GC identifiers)

Start:
49,950,327 bp from pter      End:
49,961,936 bp from pter
Size:
11,610 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MCRS1_HUMAN, Q96EZ8 (See protein sequence)
Recommended Name: Microspherule protein 1  
Size: 462 amino acids; 51803 Da
Subunit: Binds to NOP2, DAXX, PINX1, TERT and Herpes simplex virus ICP22. Interacts with CCDC85B. Component of the
chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of
INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1,
WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX,
MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9
and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20,
OGT1/OGT, WDR5 and HCFC1
Developmental stage: Cell-cycle regulated: levels are highest early in S phase; not detectable in G2
Sequence caution: Sequence=AAC68599.1; Type=Frameshift; Positions=Several;
Secondary accessions: O14742 O75497 Q6VN53
Alternative splicing: 3 isoforms:  Q96EZ8-1   Q96EZ8-2   Q96EZ8-3   (No experimental confirmation available. May be due to intron retention)

Explore the universe of human proteins at neXtProt for MCRS1: NX_Q96EZ8

Explore proteomics data for MCRS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys186
  • Modification sites at PhosphoSitePlus

  • See MCRS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012300.1  NP_001265270.1  NP_006328.2  

    ENSEMBL proteins: 
     ENSP00000448947   ENSP00000447739   ENSP00000345358   ENSP00000448056   ENSP00000448700  
     ENSP00000349640   ENSP00000447514   ENSP00000450352   ENSP00000449343   ENSP00000447592  
     ENSP00000444982  
    Reactome Protein details: Q96EZ8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    INO80: INO80 complex subunits

    3 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR000253 FHA_dom
     IPR025999 MCRS_N

    Graphical View of Domain Structure for InterPro Entry Q96EZ8

    ProtoNet protein and cluster: Q96EZ8

    1 Blocks protein domain: IPB000253 Forkhead-associated (FHA)

    UniProtKB/Swiss-Prot: MCRS1_HUMAN, Q96EZ8
    Similarity: Contains 1 FHA domain


    Find genes that share domains with MCRS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCRS1_HUMAN, Q96EZ8
    Function: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the
    NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative
    regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation,
    DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity

         Genatlas biochemistry entry for MCRS1:
    microspherule protein 1,nucleolar,associated with the proliferation-related nucleolar protein which is detectable
    early in the G1 phase of the cell cycle and peaks early in the S phase,potentially affecting the size and shape
    of the nucleolus

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11948183
    GO:0043995contributes to histone acetyltransferase activity (H4-K5 specific) IDA--
    GO:0043996contributes to histone acetyltransferase activity (H4-K8 specific) IDA--
    GO:0046972contributes to histone acetyltransferase activity (H4-K16 specific) IDA--
         
    Find genes that share ontologies with MCRS1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MCRS1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MCRS1

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    miRTarBase miRNAs that target MCRS1:
    hsa-mir-320a (MIRT044730), hsa-mir-324-3p (MIRT043001), hsa-mir-193b-3p (MIRT041247)

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    3 qRT-PCR Assays for microRNAs that regulate MCRS1:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidMCRS1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCRS1_HUMAN, Q96EZ8: Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS9765390

    Find genes that share ontologies with MCRS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MCRS1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Influenza A
    Herpes simplex infection0.33


    Find genes that share SuperPaths with MCRS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MCRS1
        HATs acetylate histones


    1 Kegg Pathway  (Kegg details for MCRS1):
        Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MCRS1
    Interactions:

        GeneGlobe Interaction Network for MCRS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MCRS1 (Q96EZ81, 2, 3 ENSP000003496404) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404252, 3, ENSP000004039484MINT-62569 MINT-62667 MINT-62743 I2D: score=4 STRING: ENSP00000403948
    ENSG00000237344P404252, 3, ENSP000003971774MINT-62569 MINT-62667 MINT-62743 I2D: score=4 STRING: ENSP00000397177
    PBX2P404252, 3, ENSP000003641904MINT-62569 MINT-62667 MINT-62743 I2D: score=4 STRING: ENSP00000364190
    ENSG00000206315P404252, 3MINT-62569 MINT-62667 MINT-62743 I2D: score=4 
    ENSG00000224952P404252, 3MINT-62569 MINT-62667 MINT-62743 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with MCRS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for MCRS1

    5 Novoseek inferred chemical compound relationships for MCRS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bromodeoxyuridine 13.9 1 11685767 (1)
    gnrh 8.98 2 8892357 (1)
    calcium 0 1 11043407 (1)
    estrogen 0 1 9264503 (1)
    ascorbic acid 0 1 2134885 (1)



    Find genes that share compounds with MCRS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MCRS1 gene (3 alternative transcripts): 
    NM_001012300.1  NM_001278341.1  NM_006337.4  

    Unigene Cluster for MCRS1:

    Microspherule protein 1
    Hs.25313  [show with all ESTs]
    Unigene Representative Sequence: NM_006337
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551598 ENST00000548602(uc009zlj.1) ENST00000551625(uc001rui.1 uc001ruj.2)
    ENST00000343810(uc001ruk.1) ENST00000550165 ENST00000552596 ENST00000548646
    ENST00000547182 ENST00000357123 ENST00000549000 ENST00000553173 ENST00000548334
    ENST00000548596 ENST00000549528 ENST00000552206 ENST00000546244
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    Additional mRNA sequence: 

    AF015308.1 AK308581.1 AY336730.1 BC011794.2 BX538079.1 

    19 DOTS entries:

    DT.91773993  DT.97856875  DT.95368922  DT.100815564  DT.100815577  DT.100815579  DT.91773991  DT.40113414 
    DT.100815572  DT.100815575  DT.86854215  DT.40110266  DT.117017  DT.100037096  DT.100699067  DT.100830494 
    DT.95368932  DT.97822491  DT.75127856 

    Selected AceView cDNA sequences (see all 391):

    BC011794 BM560011 BU169241 CR618696 BU557102 BM798061 CR591814 BU845500 
    AL527338 AA906157 BM908961 AL556840 AL552306 BQ880075 BM798042 BX417711 
    CR622765 BE794097 C05235 BM811539 BM549097 CR598264 CR609392 BE313109 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MCRS1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^
    SP1:              -     -     -     -     -           -     -     -           -                                                                                 
    SP2:                                                              -           -                                                                                 
    SP3:                                                                          -                                                                                 
    SP4:              -     -     -     -     -     -     -     -     -           -                                                                                 
    SP5:              -     -                             -     -     -           -                                                                                 

    ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:        -                                             
    SP2:        -                                             
    SP3:        -                                             
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for MCRS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MCRS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCGGTACC
    MCRS1 Expression
    About this image

    MCRS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCRS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25313

    UniProtKB/Swiss-Prot: MCRS1_HUMAN, Q96EZ8
    Tissue specificity: Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine,
    colon and leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MCRS1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcrs11 , 5 microspherule protein 11, 5 91.43(n)1
    98.26(a)1
      15 (56.09 cM)5
    518121  NM_016766.31  NP_058046.21 
     992428185 
    chicken
    (Gallus gallus)
    Aves MCRS11 microspherule protein 1 81.16(n)
    86.72(a)
      426664  XM_001232506.3  XP_001232507.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    91(a)
    83(a)
    many → 1
    many → 1
    GL343198.1(2017002-2026146)
    AAWZ02039402(2445-4418)
    African clawed frog
    (Xenopus laevis)
    Amphibia mcrs1-prov2 microspherule protein 1 76.4(n)    BC056006.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.239622 Danio rerio cDNA clone MGC66428 IMAGE2599580, complete more 78.23(n)    BC055653.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG11353
    Rcd51
    Reduction in Cnn dots 51 58(a)3
    60.74(n)1
    60.24(a)1
      64A43
    384781  NM_139595.31  NP_647852.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mcrs-16
    Protein MCRS-1 (mcrs-1) mRNA, complete cds
    24(a)
    1 ↔ 1
    I(12647376-12652087) WBGene00010420


    ENSEMBL Gene Tree for MCRS1 (if available)
    TreeFam Gene Tree for MCRS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MCRS1 gene
    1 SIMAP similar gene for MCRS1 using alignment to 9 protein entries:     MCRS1_HUMAN (see all proteins):
    DKFZp686N07218

    Find genes that share paralogs with MCRS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCRS1 (see all 249)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354734
    A colorectal cancer sample4--see VAR_0354732 V I mis40--------
    rs1859917521,2
    C--49952635(+) ACCACA/GGAGTT 4 S syn11Minor allele frequency- G:0.00EU 1257
    rs23033051,2
    C,F,O,H--49952668(-) GTGCTC/TTGTGG 4 L syn1 ese328Minor allele frequency- T:0.10EA NA NS WA CSA EU 9914
    rs1498855711,2
    C,F--49952674(+) AGCACC/TGGCCG 4 P syn11Minor allele frequency- T:0.00NA 4550
    rs2003177191,2
    C--49952679(+) CGGCCA/GTCCAT 4 R W mis10--------
    rs1140913951,2
    C--49952702(+) GCCGTC/TGACCC 4 Q R mis10--------
    rs1411440571,2
    C--49952763(+) GGAAGC/TAGAAA 2 -- int10--------
    rs1914874931,2
    C,F--49952781(+) GGGATG/AATGGG 2 -- int11Minor allele frequency- A:0.00EU 1323
    rs1498741411,2
    C--49953124(+) AAGAAC/TTGGGG 2 -- int10--------
    rs1451225261,2
    C--49953207(+) CAGCCA/TAAGAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for MCRS1 (49950327 - 49961936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MCRS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899071CNV Loss21882294
    nsv832406CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MCRS1
    DNA2.0 Custom Variant and Variant Library Synthesis for MCRS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609504    OMIM disorders: --

    2 diseases for MCRS1:    
    About MalaCards
    pigmented basal cell carcinoma    ampulla of vater carcinoma


    Find genes that share disorders with MCRS1           About GenesLikeMe

    8 Novoseek inferred disease relationships for MCRS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 16.1 1 12411392 (1)
    lymphoma 10.5 1 1359972 (1)
    tumors 5.3 5 10203085 (1), 19549253 (1), 17064581 (1)
    necrosis 0 3 17064581 (1)
    aids 0 1 8864354 (1)
    hepatitis c 0 1 16012951 (1)
    cancer 0 3 11709724 (1)
    immunodeficiency 0 1 8864354 (1)


    Export disorders for MCRS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MCRS1 gene, integrated from 10 sources (see all 115):
    (articles sorted by number of sources associating them with MCRS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. (PubMed id 9654073)1, 2, 3, 9 Ren Y.... Busch H. (Eur. J. Biochem. 1998)
    2. Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells. (PubMed id 9765390)1, 2, 3 Bruni R. and Roizman B. (J. Virol. 1998)
    3. Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. (PubMed id 15044100)1, 2, 9 Song H....Zhao M. (Biochem. Biophys. Res. Commun. 2004)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (J. Biol. Chem. 2011)
    5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T.... Conaway J.W. (Mol. Cell 2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PubMed id 17014843)1, 2 Du X.... Greene M.I. (Exp. Mol. Pathol. 2006)
    8. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. (PubMed id 11948183)1, 2 Lin D.-Y. and Shih H.-M. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10445 HGNC: 6960 AceView: MCRS1 Ensembl:ENSG00000187778 euGenes: HUgn10445
    ECgene: MCRS1 Kegg: 10445 H-InvDB: MCRS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MCRS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MCRS1 gene:
    Search GeneIP for patents involving MCRS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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