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Aliases for MCRS1 Gene

Aliases for MCRS1 Gene

  • Microspherule Protein 1 2 3
  • Cell Cycle-Regulated Factor P78 3 4
  • 58 KDa Microspherule Protein 3 4
  • INO80 Complex Subunit Q 2 3
  • INO80 Complex Subunit J 3 4
  • INO80Q 3 4
  • MCRS2 3 4
  • MSP58 3 4
  • Cell Cycle-Regulated Factor (78 KDa) 3
  • ICP22BP 3
  • P78 3

External Ids for MCRS1 Gene

Summaries for MCRS1 Gene

GeneCards Summary for MCRS1 Gene

MCRS1 (Microspherule Protein 1) is a Protein Coding gene. Diseases associated with MCRS1 include pigmented basal cell carcinoma and ampulla of vater carcinoma. Among its related pathways are Influenza A and RNA Polymerase I Promoter Opening. GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).

UniProtKB/Swiss-Prot for MCRS1 Gene

  • Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.

Gene Wiki entry for MCRS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCRS1 Gene

Genomics for MCRS1 Gene

Genomic Location for MCRS1 Gene

Start:
49,556,544 bp from pter
End:
49,568,153 bp from pter
Size:
11,610 bases
Orientation:
Minus strand

Genomic View for MCRS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCRS1 Gene

Regulatory Elements for MCRS1 Gene

Proteins for MCRS1 Gene

  • Protein details for MCRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EZ8-MCRS1_HUMAN
    Recommended name:
    Microspherule protein 1
    Protein Accession:
    Q96EZ8
    Secondary Accessions:
    • O14742
    • O75497
    • Q6VN53
    • Q7Z372

    Protein attributes for MCRS1 Gene

    Size:
    462 amino acids
    Molecular mass:
    51803 Da
    Quaternary structure:
    • Binds to NOP2, DAXX, PINX1, TERT and Herpes simplex virus ICP22. Interacts with CCDC85B. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
    SequenceCaution:
    • Sequence=AAC68599.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for MCRS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCRS1 Gene

Proteomics data for MCRS1 Gene at MOPED

Post-translational modifications for MCRS1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys186

No data available for DME Specific Peptides for MCRS1 Gene

Domains for MCRS1 Gene

Gene Families for MCRS1 Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for MCRS1 Gene

UniProtKB/Swiss-Prot:

MCRS1_HUMAN
Domain:
  • Contains 1 FHA domain.:
    • Q96EZ8
genes like me logo Genes that share domains with MCRS1: view

Function for MCRS1 Gene

Molecular function for MCRS1 Gene

GENATLAS Biochemistry: microspherule protein 1,nucleolar,associated with the proliferation-related nucleolar protein which is detectable early in the G1 phase of the cell cycle and peaks early in the S phase,potentially affecting the size and shape of the nucleolus
UniProtKB/Swiss-Prot Function: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.

Gene Ontology (GO) - Molecular Function for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11948183
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IDA 20018852
GO:0043996 contributes_to histone acetyltransferase activity (H4-K8 specific) IDA 20018852
GO:0046972 contributes_to histone acetyltransferase activity (H4-K16 specific) IDA 20018852
genes like me logo Genes that share ontologies with MCRS1: view
genes like me logo Genes that share phenotypes with MCRS1: view

miRNA for MCRS1 Gene

miRTarBase miRNAs that target MCRS1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCRS1 Gene

Localization for MCRS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCRS1 Gene

Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCRS1 Gene COMPARTMENTS Subcellular localization image for MCRS1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MCRS1: view

Pathways for MCRS1 Gene

genes like me logo Genes that share pathways with MCRS1: view

Pathways by source for MCRS1 Gene

1 KEGG pathway for MCRS1 Gene

Gene Ontology (GO) - Biological Process for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MCRS1: view

Compounds for MCRS1 Gene

(5) Novoseek inferred chemical compound relationships for MCRS1 Gene

Compound -log(P) Hits PubMed IDs
bromodeoxyuridine 13.9 1
gnrh 8.98 1
calcium 0 1
estrogen 0 1
ascorbic acid 0 1
genes like me logo Genes that share compounds with MCRS1: view

Transcripts for MCRS1 Gene

Unigene Clusters for MCRS1 Gene

Microspherule protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCRS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - -
SP2: - -
SP3: -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6:
SP7: - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -
SP11: - - - -
SP12: - - - - -

ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c · 17d
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MCRS1 Gene

GeneLoc Exon Structure for
MCRS1
ECgene alternative splicing isoforms for
MCRS1

Expression for MCRS1 Gene

mRNA expression in normal human tissues for MCRS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCRS1 Gene

SOURCE GeneReport for Unigene cluster for MCRS1 Gene Hs.25313

mRNA Expression by UniProt/SwissProt for MCRS1 Gene

Q96EZ8-MCRS1_HUMAN
Tissue specificity: Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes
genes like me logo Genes that share expressions with MCRS1: view

Orthologs for MCRS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCRS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCRS1 36
  • 99.79 (n)
  • 100 (a)
MCRS1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCRS1 36
  • 93.17 (n)
  • 99.35 (a)
MCRS1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCRS1 36
  • 93.26 (n)
  • 98.95 (a)
MCRS1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcrs1 36
  • 91.43 (n)
  • 98.26 (a)
Mcrs1 16
Mcrs1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCRS1 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCRS1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcrs1 36
  • 91.29 (n)
  • 98.47 (a)
chicken
(Gallus gallus)
Aves MCRS1 36
  • 81.16 (n)
  • 86.72 (a)
MCRS1 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 83 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia mcrs1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mcrs1 36
  • 73.39 (n)
  • 85.2 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.23962 36
mcrs1 36
  • 71.34 (n)
  • 77.95 (a)
mcrs1 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005560 36
  • 65.5 (n)
  • 63.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rcd5 36
  • 60.74 (n)
  • 60.24 (a)
Rcd5 37
  • 41 (a)
OneToOne
CG1135 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea mcrs-1 37
  • 24 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8684 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToOne
Species with no ortholog for MCRS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCRS1 Gene

ENSEMBL:
Gene Tree for MCRS1 (if available)
TreeFam:
Gene Tree for MCRS1 (if available)

Paralogs for MCRS1 Gene

Selected SIMAP similar genes for MCRS1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with MCRS1: view

No data available for Paralogs for MCRS1 Gene

Variants for MCRS1 Gene

Sequence variations from dbSNP and Humsavar for MCRS1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13066 -- 49,566,768(-) AGCCC(G/T)GTGGT upstream-variant-2KB, intron-variant, utr-variant-5-prime
rs1248365 -- 49,568,784(-) TCCCA(C/T)CCCAA upstream-variant-2KB
rs2288077 -- 49,560,065(-) CTTCC(A/G)GGCCA intron-variant
rs2303305 -- 49,558,885(-) GTGCT(C/T)TGTGG reference, synonymous-codon
rs4144469 -- 49,567,366(+) CTCGT(C/G)gaaac upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCRS1 Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV Loss 17160897
nsv899071 CNV Loss 21882294

Relevant External Links for MCRS1 Gene

HapMap Linkage Disequilibrium report
MCRS1

Disorders for MCRS1 Gene

(8) Novoseek inferred disease relationships for MCRS1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 16.1 1
lymphoma 10.5 1
tumors 5.3 3
necrosis 0 1
aids 0 1
genes like me logo Genes that share disorders with MCRS1: view

No data available for UniProtKB/Swiss-Prot for MCRS1 Gene

Publications for MCRS1 Gene

  1. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. (PMID: 9654073) Ren Y. … Busch H. (Eur. J. Biochem. 1998) 2 3 4 23
  2. Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. (PMID: 15044100) Song H. … Zhao M. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  3. Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells. (PMID: 9765390) Bruni R. … Roizman B. (J. Virol. 1998) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. (PMID: 11948183) Lin D.-Y. … Shih H.-M. (J. Biol. Chem. 2002) 3 4

Products for MCRS1 Gene

Sources for MCRS1 Gene

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