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Aliases for MCRIP2 Gene

Aliases for MCRIP2 Gene

  • MAPK Regulated Corepressor Interacting Protein 2 2 3 5
  • Family With Sequence Similarity 195, Member A 2 3
  • C16orf14 3 4
  • FAM195A 3 4
  • MAPK Regulated Co-Repressor Interacting Protein 2 3
  • Family With Sequence Similarity 195 Member A 2
  • Chromosome 16 Open Reading Frame 14 2
  • Protein FAM195A 3
  • C349E10.1 3

External Ids for MCRIP2 Gene

Previous HGNC Symbols for MCRIP2 Gene

  • C16orf14
  • FAM195A

Summaries for MCRIP2 Gene

GeneCards Summary for MCRIP2 Gene

MCRIP2 (MAPK Regulated Corepressor Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is MCRIP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCRIP2 Gene

Genomics for MCRIP2 Gene

Regulatory Elements for MCRIP2 Gene

Enhancers for MCRIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MCRIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCRIP2 Gene

Chromosome:
16
Start:
636,817 bp from pter
End:
648,474 bp from pter
Size:
11,658 bases
Orientation:
Plus strand

Genomic View for MCRIP2 Gene

Genes around MCRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCRIP2 Gene

Proteins for MCRIP2 Gene

  • Protein details for MCRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUT9-F195A_HUMAN
    Recommended name:
    Protein FAM195A
    Protein Accession:
    Q9BUT9
    Secondary Accessions:
    • Q969E9
    • Q96KV8

    Protein attributes for MCRIP2 Gene

    Size:
    160 amino acids
    Molecular mass:
    17828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MCRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCRIP2 Gene

Post-translational modifications for MCRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCRIP2 Gene

No data available for DME Specific Peptides for MCRIP2 Gene

Domains & Families for MCRIP2 Gene

Protein Domains for MCRIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCRIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUT9

UniProtKB/Swiss-Prot:

F195A_HUMAN :
  • Belongs to the FAM195 family.
Family:
  • Belongs to the FAM195 family.
genes like me logo Genes that share domains with MCRIP2: view

No data available for Gene Families for MCRIP2 Gene

Function for MCRIP2 Gene

Phenotypes for MCRIP2 Gene

genes like me logo Genes that share phenotypes with MCRIP2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCRIP2 Gene

Localization for MCRIP2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MCRIP2 Gene

Pathways & Interactions for MCRIP2 Gene

SuperPathways for MCRIP2 Gene

No Data Available

Interacting Proteins for MCRIP2 Gene

Selected Interacting proteins: Q9BUT9-F195A_HUMAN for MCRIP2 Gene via IID

Gene Ontology (GO) - Biological Process for MCRIP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MCRIP2 Gene

Drugs & Compounds for MCRIP2 Gene

No Compound Related Data Available

Transcripts for MCRIP2 Gene

Unigene Clusters for MCRIP2 Gene

Family with sequence similarity 195, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCRIP2 Gene

No ASD Table

Relevant External Links for MCRIP2 Gene

GeneLoc Exon Structure for
MCRIP2
ECgene alternative splicing isoforms for
MCRIP2

Expression for MCRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MCRIP2 Gene:

MCRIP2

SOURCE GeneReport for Unigene cluster for MCRIP2 Gene:

Hs.706105
genes like me logo Genes that share expression patterns with MCRIP2: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MCRIP2 Gene

Orthologs for MCRIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM195A 34
  • 91.18 (n)
  • 91.61 (a)
FAM195A 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam195a 34
  • 85.83 (n)
  • 85 (a)
Fam195a 16
Fam195a 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM195A 34
  • 99.37 (n)
  • 99.37 (a)
FAM195A 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam195a 34
  • 87.5 (n)
  • 85 (a)
dog
(Canis familiaris)
Mammalia FAM195A 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM195A 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM195A 34
  • 73.43 (n)
  • 65.73 (a)
FAM195A 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam195a 34
  • 57.41 (n)
  • 54.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-44g23.5 34
  • 67.38 (n)
  • 62.86 (a)
FAM195A 35
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10574 34
Species where no ortholog for MCRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCRIP2 Gene

ENSEMBL:
Gene Tree for MCRIP2 (if available)
TreeFam:
Gene Tree for MCRIP2 (if available)

Paralogs for MCRIP2 Gene

Paralogs for MCRIP2 Gene

Pseudogenes.org Pseudogenes for MCRIP2 Gene

genes like me logo Genes that share paralogs with MCRIP2: view

Variants for MCRIP2 Gene

Sequence variations from dbSNP and Humsavar for MCRIP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9940108 -- 646,499(+) ACCGA(A/G)AGCGG intron-variant
rs34281779 -- 643,849(+) TCCCC(-/C)ATGTG intron-variant
rs11643113 -- 644,174(+) CCTCC(C/T)GGGTT intron-variant
rs1810458 -- 645,287(+) AGTCT(C/T)GCTCT intron-variant
rs72767895 -- 645,698(+) GGGAC(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv334n27 CNV loss 19166990
dgv4823n54 CNV loss 21841781
dgv4824n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv2663331 CNV deletion 23128226
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571015 CNV loss 21841781
nsv833114 CNV gain+loss 17160897
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for MCRIP2 Gene

Gene Damage Index Score: 0.32; 7.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCRIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCRIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCRIP2 Gene

Disorders for MCRIP2 Gene

Relevant External Links for MCRIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCRIP2

No disorders were found for MCRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCRIP2 Gene

Publications for MCRIP2 Gene

  1. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R. … Vogel C. (Biomolecules 2015) 2 3 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for MCRIP2 Gene

Sources for MCRIP2 Gene

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