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Aliases for MCRIP1 Gene

Aliases for MCRIP1 Gene

  • MAPK Regulated Co-Repressor Interacting Protein 1 2 3
  • Family With Sequence Similarity 195 Member B 2 3 5
  • Family With Sequence Similarity 195, Member B 2 3
  • Protein FAM195B 3 4
  • Granulin-2 2 3
  • FAM195B 3 5
  • MAPK-Regulated Co-Repressor Interacting Protein 1 3
  • MCRIP1 Protein 3
  • GRAN2 3
  • MCRIP 3

External Ids for MCRIP1 Gene

Previous HGNC Symbols for MCRIP1 Gene

  • FAM195B

Summaries for MCRIP1 Gene

GeneCards Summary for MCRIP1 Gene

MCRIP1 (MAPK Regulated Co-Repressor Interacting Protein 1) is a Protein Coding gene. An important paralog of this gene is MCRIP2.

UniProtKB/Swiss-Prot for MCRIP1 Gene

  • The phosphorylation status of FAM195B functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated FAM195B binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, FAM195B releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCRIP1 Gene

Genomics for MCRIP1 Gene

Regulatory Elements for MCRIP1 Gene

Enhancers for MCRIP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MCRIP1 on UCSC Golden Path with GeneCards custom track

Promoters for MCRIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MCRIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCRIP1 Gene

Chromosome:
17
Start:
81,822,361 bp from pter
End:
81,833,302 bp from pter
Size:
10,942 bases
Orientation:
Minus strand

Genomic View for MCRIP1 Gene

Genes around MCRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCRIP1 Gene

Proteins for MCRIP1 Gene

  • Protein details for MCRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JLW8-F195B_HUMAN
    Recommended name:
    Mapk-regulated corepressor-interacting protein 1
    Protein Accession:
    C9JLW8
    Secondary Accessions:
    • Q6ZUL0

    Protein attributes for MCRIP1 Gene

    Size:
    97 amino acids
    Molecular mass:
    10920 Da
    Quaternary structure:
    • Interacts (unphosphorylated form, via the PXDLS motif) with CTBP1, competitively inhibiting CTBP-ZEB1 interaction (PubMed:25728771). Interacts with CTBP2 (PubMed:25728771).
    SequenceCaution:
    • Sequence=BAC86211.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for MCRIP1 Gene

Proteomics data for MCRIP1 Gene at MOPED

Post-translational modifications for MCRIP1 Gene

  • Phosphorylation by MAPK3/1 (ERK1/2) regulates FAM195B binding to CTBP(s) (PubMed:25728771).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MCRIP1 Gene

Domains & Families for MCRIP1 Gene

Protein Domains for MCRIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JLW8

UniProtKB/Swiss-Prot:

F195B_HUMAN :
  • Belongs to the FAM195 family.
Family:
  • Belongs to the FAM195 family.
genes like me logo Genes that share domains with MCRIP1: view

No data available for Gene Families for MCRIP1 Gene

Function for MCRIP1 Gene

Molecular function for MCRIP1 Gene

UniProtKB/Swiss-Prot Function:
The phosphorylation status of FAM195B functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated FAM195B binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, FAM195B releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).
genes like me logo Genes that share phenotypes with MCRIP1: view

Animal Model Products

miRNA for MCRIP1 Gene

miRTarBase miRNAs that target MCRIP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCRIP1 Gene

Localization for MCRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCRIP1 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MCRIP1 Gene

Pathways & Interactions for MCRIP1 Gene

SuperPathways for MCRIP1 Gene

No Data Available

Interacting Proteins for MCRIP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000409009%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000409009 C9JLW8-F195B_HUMAN for MCRIP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MCRIP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MCRIP1 Gene

Drugs & Compounds for MCRIP1 Gene

No Compound Related Data Available

Transcripts for MCRIP1 Gene

Unigene Clusters for MCRIP1 Gene

Family with sequence similarity 195, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCRIP1 Gene

No ASD Table

Relevant External Links for MCRIP1 Gene

GeneLoc Exon Structure for
MCRIP1
ECgene alternative splicing isoforms for
MCRIP1

Expression for MCRIP1 Gene

SOURCE GeneReport for Unigene cluster for MCRIP1 Gene Hs.514632

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MCRIP1 Gene

Orthologs for MCRIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM195B 35
  • 91.41 (n)
  • 90.72 (a)
FAM195B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM195B 35
  • 88.89 (n)
  • 85.96 (a)
FAM195B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam195b 35
  • 88.66 (n)
  • 90.72 (a)
Fam195b 16
Fam195b 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM195B 35
  • 99.72 (n)
  • 100 (a)
FAM195B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam195b 35
  • 87.29 (n)
  • 90.72 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM195B 36
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM195B 35
  • 81.56 (n)
  • 85.11 (a)
lizard
(Anolis carolinensis)
Reptilia FAM195B 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam195b 35
  • 70.1 (n)
  • 78.35 (a)
Str.12007 35
zebrafish
(Danio rerio)
Actinopterygii fam195b 35
  • 63.51 (n)
  • 60 (a)
fam195b 36
  • 58 (a)
OneToOne
Species with no ortholog for MCRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCRIP1 Gene

ENSEMBL:
Gene Tree for MCRIP1 (if available)
TreeFam:
Gene Tree for MCRIP1 (if available)

Paralogs for MCRIP1 Gene

Paralogs for MCRIP1 Gene

genes like me logo Genes that share paralogs with MCRIP1: view

Variants for MCRIP1 Gene

Sequence variations from dbSNP and Humsavar for MCRIP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1047441 -- 81,822,805(-) GCCCC(A/C)CCCCA utr-variant-3-prime
rs1047559 -- 81,822,531(-) TGGCT(C/T)TGGGG utr-variant-3-prime
rs1047580 -- 81,822,467(-) AGTGT(C/T)TGTGT utr-variant-3-prime
rs4013609 -- 81,826,522(-) TTTTT(-/TT)GACAC intron-variant, upstream-variant-2KB
rs3187588 -- 81,822,482(-) GCCCT(C/T)TGAAA utr-variant-3-prime

Variation tolerance for MCRIP1 Gene

Gene Damage Index Score: 0.28; 6.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MCRIP1 Gene

Disorders for MCRIP1 Gene

Relevant External Links for MCRIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCRIP1

No disorders were found for MCRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCRIP1 Gene

Publications for MCRIP1 Gene

  1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. (PMID: 25728771) Ichikawa K. … Takekawa M. (Mol. Cell 2015) 2 3 4 67
  2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R. … Vogel C. (Biomolecules 2015) 2 3
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for MCRIP1 Gene

Sources for MCRIP1 Gene

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