MCPH1 Gene
protein-coding GIFtS: 53
GCID: GC08P006276
|
|
microcephalin 1(Previous names: microcephaly, primary autosomal recessive 1 )
| |
Aliases
for MCPH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microcephalin 11 2 | | MCT2 | | BRIT11 2 | | BRCT-Repeat Inhibitor Of TERT Expression 12 | | FLJ128471 | | Microcephalin1 | | Microcephaly, Primary Autosomal Recessive 11 | | |
Export aliases for MCPH1 gene to outside databasesPrevious GC identifers: GC08U990048 GC08P006046 |
Summaries
for MCPH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MCPH1:
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest viamaintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associatedwith primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively splicedtranscript variants have been described. (provided by RefSeq, Feb 2010)
UniProtKB/Swiss-Prot: MCPH1_HUMAN, Q8NEM0Function: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role inneurogenesis and regulation of the size of the cerebral cortex
|
Genomic Views
for MCPH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_023736.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MCPH1 gene promoter:
GR PPAR-gamma1 PPAR-gamma2 GR-alpha Zic3 HNF-4alpha1 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MCPH1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCPH1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1MCPH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P006276: view genomic region
(about GC identifiers)
Start:
|
6,264,113 bp from pter |
End:
|
6,501,144 bp from pter |
Size:
|
237,032 bases |
Orientation:
|
plus strand |
|
Proteins
for MCPH1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MCPH1_HUMAN, Q8NEM0 (See
protein sequence)Recommended Name: Microcephalin Size: 835 amino acids; 92877 Da
Subunit: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AFXunder DNA damage conditions
Subcellular location: Cytoplasm, cytoskeleton, centrosome
Miscellaneous: MCPH1 deficient cells exhibit a delay in post-mitotic chromosome decondensation
6/8 PDB 3D structures from  and Proteopedia  for MCPH1 (see all 8):2WT8 (3D)
3KTF (3D)
3PA6 (3D)
3SHT (3D)
3SHV (3D)
3SZM (3D)
Secondary accessions: B4DWW2 E9PH63 Q66GU1 Q9H9C7Alternative splicing: 2 isoforms: Q8NEM0-1 Q8NEM0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MCPH1: NX_Q8NEM0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NEM0
MCPH1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001166045.1 NP_001166046.1 NP_078872.2
ENSEMBL proteins: ENSP00000342924 ENSP00000430962 ENSP00000430768
Human Recombinant Protein Products for MCPH1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | | GO:0005815 | microtubule organizing center |
IEA | -- |
MCPH1 for ontologies About GeneDecksing
MCPH1 Antibody Products:
Assay Products for MCPH1: |
Protein
Domains /
Families
for MCPH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MCPH1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NEM0ProtoNet protein and cluster: Q8NEM0 1 Blocks protein family: IPB001357 BRCT domain
UniProtKB/Swiss-Prot: MCPH1_HUMAN, Q8NEM0Domain: BRCT domain 1 is required to prevent abnormal chromosome condensation. It binds directly to the SWI-SNFchromatin remodeling complex (PubMed:19925808)Domain: BRCT domains 2 and 3 recognize phosphoserine/phosphothreonine marks on proteins with high selectivity, andmediate interaction with phosphorylated CDC27. They also mediate the dual recognition of phosphoserine andphosphotyrosine in the C-terminal tail of histone H2AFX (PubMed:22139841, PubMed:22908299 and PubMed:22908299)Similarity: Contains 3 BRCT domains |
Function
for MCPH1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MCPH1_HUMAN, Q8NEM0Function: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role inneurogenesis and regulation of the size of the cerebral cortexPhenotypes:
1 GenomeRNAi human phenotype for MCPH1:
15 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Mcph1):
MCPH1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for MCPH1: Mcph1tm1.1Zqw Mcph1tm1.2Kali
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCPH1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCPH1 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MCPH1 (NM_024596) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCPH1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCPH1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCPH1 |
|
Pathways & Interactions
for MCPH1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell Cycle / Checkpoint Control | | | 2 | DNA Damage | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for MCPH1
MCPH1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCPH1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/28 Interacting proteins for MCPH1 (Q8NEM02, 3 ENSP000003429244) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010468 | regulation of gene expression |
IEA | -- | | GO:0043549 | regulation of kinase activity |
IEA | -- |
MCPH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MCPH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MCPH1
Search CenterWatch for drugs/clinical trials and news about MCPH1
|
Transcripts
for MCPH1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MCPH1 gene (3 alternative transcripts): NM_001172574.1 NM_001172575.1 NM_024596.3 Unigene Clusters for MCPH1: Microcephalin 1 Hs.656769 [show with all ESTs], Hs.708770 [show with all ESTs], Hs.721952 [show with all ESTs]Unigene Representative Sequences: NM_001172574, AK023946, AK0579957 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344683(uc003wqi.3) ENST00000519480(uc003wqh.3 uc011kwl.2)
ENST00000522905 ENST00000522020 ENST00000519221 ENST00000521129 ENST00000521175
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCPH1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCPH1 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MCPH1 (NM_024596) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCPH1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCPH1 |
Additional cDNA sequence: AK057995.1 12 DOTS entries: DT.40290903 DT.451868 DT.101982162 DT.121490450 DT.121490428 DT.75101554 DT.121490422 DT.92005685 DT.100733204 DT.95343922 DT.75138141 DT.302800 24/122 AceView cDNA sequences (see all 122): AA971737 AA683496 AW292069 AA808319 BM785850 W38626 AI379664 BX279580 CR593857 BQ067939 AA315143 BU171121 AW874272 AI393682 BX114663 BX106592 AW161535 BE672357 BM543033 BX375871 CA418259 AI274636 BM551704 BV206198
GeneLoc Exon Structure
|
Expression
for MCPH1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MCPH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MCPH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCPH1
SOURCE GeneReport for Unigene clusters: Hs.656769 Hs.708770 Hs.721952
UniProtKB/Swiss-Prot: MCPH1_HUMAN, Q8NEM0Tissue specificity: Expressed in fetal brain, liver and kidney
SABiosciences Expression via Pathway-Focused PCR Array including MCPH1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCPH1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MCPH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCPH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCPH1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCPH1 |
Orthologs
for MCPH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MCPH1 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mcph11 , 5 |
microcephaly, primary autosomal recessive 11, 5 |
71.57(n)1
59.92(a)1 |
|
8 (10.24 cM)5
2443291 NM_173189.21 NP_775281.21
185951315 |
chicken
(Gallus gallus) |
Aves |
MCPH11 |
microcephaly, primary autosomal recessive 1 |
57.75(n)
52.08(a) |
|
100125976 NM_001105319.1 NP_001098789.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MCPH16 |
-- |
58(a) |
1 ↔ 1 |
1(152001391-152108196) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ096643.12 |
-- |
75.4(n) |
|
BJ096643.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.154632 |
Transcribed sequence with weak similarity to protein more |
74.24(n) |
|
AL718650.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
MCPH16 |
Microcephalin |
15(a) |
1 ↔ 1 |
2R(7783499-7791429) |
ENSEMBL Gene Tree for MCPH1 (if available)
TreeFam Gene Tree for MCPH1 (if available) |
Paralogs
for MCPH1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MCPH1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MCPH1 (6264113 - 6501144 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MCPH1
3 CNVs: 5250 39519 52596
Human Gene Mutation Database (HGMD): MCPH1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCPH1 |
|
Disorders
/ Diseases
for MCPH1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MCPH1 for disorders About GeneDecksing
OMIM gene information: 607117
OMIM disorders: 251200 606858
UniProtKB/Swiss-Prot: MCPH1_HUMAN, Q8NEM0
Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as truemicrocephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviationsbelow the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small.Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality incortical architecture. Primary microcephaly is further defined by the absence of other syndromic features orsignificant neurological deficits. This entity is inherited as autosomal recessive trait
20/21  diseases for MCPH1 (see all 21): About MalaCardsmicrocephaly primary autosomal recessive microcephaly premature chromosome condensation with microcephaly and mental retardation seckel syndrome
autism spectrum disorder ataxia telangiectasia multiple system atrophy intellectual disability
chronic myeloid leukemia myeloid leukemia malignant glioma craniosynostosis
hereditary pancreatitis ataxia pancreatitis pancreatic cancer
leukemia breast cancer atherosclerosis cerebritis
3 diseases from the University of Copenhagen DISEASES database for MCPH1:Microcephaly Seckel syndrome Intellectual disability 5 Novoseek disease relationships for MCPH1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| microcephaly, primary |
98.7 |
29 |
15199523 (2), 19549900 (1), 19267414 (1), 12571366 (1) (see all 17) |
| microcephaly |
84.4 |
21 |
19267414 (2), 16687438 (1), 15018946 (1), 15917198 (1) (see all 11) |
| seckel syndrome |
81.4 |
3 |
16217032 (1), 19546241 (1) |
| ataxia telangiectasia |
57.1 |
3 |
15018946 (1), 19546241 (1) |
| mental retardation |
57 |
6 |
19267414 (2), 17925396 (1) |
GeneTests: MCPH1
Primary Autosomal Recessive Microcephaly
Human Genome Epidemiology (HuGE) Navigator: MCPH1 (14 documents)
Export disorders for MCPH1 gene to outside databases
|
Publications
for MCPH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MCPH1 gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with MCPH1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. (PubMed id 17925396)1, 3, 9 Wood J.L....Chen J. (2007)
- Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. (PubMed id 15220350)1, 2, 9 Xu X.... Stern D.F. (2004)
- Mutations in microcephalin cause aberrant regulation of chromosome condensation. (PubMed id 15199523)1, 2, 9 Trimborn M....Jackson A.P. (2004)
- Microcephalin encodes a centrosomal protein. (PubMed id 16479174)1, 2, 9 Zhong X.... Xu X. (2006)
- Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. (PubMed id 22908299)1, 2 Singh N....Mer G. (2012)
- Molecular basis for the association of microcephalin ( MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the an aphase-promoting complex. (PubMed id 22139841)1, 2 Singh N....Couch F.J. (2012)
- Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure. (PubMed id 22154951)1, 2 Shao Z....Shi Y. (2012)
- A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. (PubMed id 19925808)1, 2 Richards M.W....Bayliss R. (2010)
- A common SNP of MCPH1 is associated with cranial volume variation in Chinese population. (PubMed id 18204051)1, 2 Wang J.K....Su B. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for MCPH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MCPH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MCPH1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MCPH1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MCPH1 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt064.shtml |
|
| | |
About This Section
| Patent Information for MCPH1 gene:
Search GeneIP for patents involving MCPH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MCPH1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MCPH1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCPH1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCPH1 | | | OriGene Protein Over-expression Lysate for MCPH1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MCPH1 | | OriGene 3'-UTR Clone for MCPH1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCPH1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCPH1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MCPH1 | | OriGene Custom Protein Services for MCPH1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MCPH1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCPH1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCPH1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCPH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCPH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCPH1 |
| |
 |  |  |  | |
| | Antibodies & Assays for MCPH1 |
| | | | Search Tocris compounds for MCPH1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MCPH1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCPH1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MCPH1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCPH1 |
| |  | |
|
|
|
