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MCOLN2 Gene

protein-coding   GIFtS: 50
GCID: GC01M085391

Mucolipin 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mucolipin 21 2
TRP-ML22
TRPML22
mucolipin-22

External Ids:    HGNC: 133571   Entrez Gene: 2552312   Ensembl: ENSG000001538987   OMIM: 6073995   UniProtKB: Q8IZK63   

Export aliases for MCOLN2 gene to outside databases

Previous GC identifers: GC01M084529 GC01M084679 GC01M084814 GC01M084813 GC01M085103 GC01M083501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MCOLN2 Gene:
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential
superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM
607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila
and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007
(PubMed 17662026)).(supplied by OMIM, Sep 2009)

GeneCards Summary for MCOLN2 Gene:
MCOLN2 (mucolipin 2) is a protein-coding gene. Diseases associated with MCOLN2 include mucolipidosis. An important paralog of this gene is MCOLN3.

Gene Wiki entry for MCOLN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MCOLN2 gene promoter:
         AREB6   Max   N-Myc   Sp1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCOLN2 promoter sequence
   Search Chromatin IP Primers for MCOLN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCOLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22

MCOLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCOLN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085391:  view genomic region     (about GC identifiers)

Start:
85,391,266 bp from pter      End:
85,462,796 bp from pter
Size:
71,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCLN2_HUMAN, Q8IZK6 (See protein sequence)
Recommended Name: Mucolipin-2  
Size: 566 amino acids; 65942 Da
Sequence caution: Sequence=BAC04267.1; Type=Erroneous termination; Positions=64; Note=Translated as Trp;
Secondary accessions: A6NI99 Q2M3I6 Q5TAG5 Q8N9R3
Alternative splicing: 2 isoforms:  Q8IZK6-1   Q8IZK6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCOLN2: NX_Q8IZK6

Explore proteomics data for MCOLN2 at MOPED


See MCOLN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_694991.2  
ENSEMBL proteins: 
 ENSP00000359640   ENSP00000436299   ENSP00000284027  
Reactome Protein details: Q8IZK6

MCOLN2 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for MCOLN2

MCOLN2 Antibody Products:

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Cloud-Clone Corp. CLIAs for MCOLN2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TRP: Voltage-gated ion channels / Transient receptor potential cation channels

IUPHAR Guide to PHARMACOLOGY protein family classification: TRPML2
Transient Receptor Potential channels

1 InterPro protein domain:
 IPR013122 PKD1_2_channel

Graphical View of Domain Structure for InterPro Entry Q8IZK6

ProtoNet protein and cluster: Q8IZK6

UniProtKB/Swiss-Prot: MCLN2_HUMAN, Q8IZK6
Similarity: Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN2 sub-subfamily


MCOLN2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MCOLN2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MCOLN2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCOLN2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCOLN2

miRNA
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miRTarBase miRNAs that target MCOLN2:
hsa-mir-32-5p (MIRT028342), hsa-mir-92a-3p (MIRT049683)

Block miRNA regulation of human, mouse, rat MCOLN2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MCOLN2 (see all 13):
hsa-miR-374b* hsa-miR-26a-2* hsa-miR-92a hsa-miR-513a-3p hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-146a*
SwitchGear 3'UTR luciferase reporter plasmidMCOLN2 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for MCOLN2
Predesigned siRNA for gene silencing in human, mouse, rat MCOLN2

Gene Editing
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DNA2.0 Custom Protein Engineering Service for MCOLN2

Clone
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OriGene clones in human, mouse for MCOLN2 (see all 6)
OriGene ORF clones in mouse, rat for MCOLN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MCOLN2 (NM_153259)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCOLN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCOLN2

Cell Line
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GenScript Custom overexpressing Cell Line Services for MCOLN2
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCOLN2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MCLN2_HUMAN, Q8IZK6: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
cytoskeleton1
cytosol1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

MCOLN2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MCOLN2 About    
See pathways by source

SuperPathContained pathways About
1Ion channel transport
Ion channel transport0.58
Stimuli-sensing channels0.58
2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Transmembrane transport of small molecules0.47
3TRP channels
TRP channels

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for MCOLN2
    TRP channels



MCOLN2 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MCOLN2
Interactions:

    Search GeneGlobe Interaction Network for MCOLN2

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport ----
GO:0034220ion transmembrane transport TAS--
GO:0055085transmembrane transport TAS--
GO:0070588calcium ion transmembrane transport TAS--

MCOLN2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MCOLN2 (MCLN2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MCOLN2 gene: 
NM_153259.2  

Unigene Cluster for MCOLN2:

Mucolipin 2
Hs.591446  [show with all ESTs]
Unigene Representative Sequence: NM_153259
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370608(uc001dkm.3 uc001dkn.3) ENST00000463065 ENST00000530971
ENST00000284027 ENST00000531325 ENST00000531874
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MCOLN2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MCOLN2 (see all 13):
hsa-miR-374b* hsa-miR-26a-2* hsa-miR-92a hsa-miR-513a-3p hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-146a*
SwitchGear 3'UTR luciferase reporter plasmidMCOLN2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MCOLN2
Predesigned siRNA for gene silencing in human, mouse, rat MCOLN2
Clone
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OriGene clones in human, mouse for MCOLN2 (see all 6)
OriGene ORF clones in mouse, rat for MCOLN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MCOLN2 (NM_153259)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCOLN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCOLN2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for MCOLN2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCOLN2
  QuantiTect SYBR Green Assays in human, mouse, rat MCOLN2
  QuantiFast Probe-based Assays in human, mouse, rat MCOLN2

Additional mRNA sequence: 

AK094010.1 AK129786.1 AK309858.1 AY083533.1 BC104891.1 BC104893.1 

4 DOTS entries:

DT.100019001  DT.439511  DT.87015366  DT.121418605 

Selected AceView cDNA sequences (see all 27):

AY083533 BP354472 AX748410 BV206882 AI160827 N41861 AV713773 AK129786 
AI222682 AI128274 AK094010 AW377181 AI128279 BG122048 AW119125 BX115566 
AA664369 AI458257 AI915368 AI914009 BQ678209 N41435 N30618 BM999217 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MCOLN2    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1:                                                                                -                           
SP2:                                      -           -     -                       -                           
SP3:                                                                                                            


ECgene alternative splicing isoforms for MCOLN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MCOLN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MCOLN2 Expression
About this image


MCOLN2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Chondrocytes Zeugopod Epiphyseal End
         Zeugopod Growth Plate
 
 Heart (Cardiovascular System)
         Mature Cardiac Fibroblasts Myocardium
 
 Fibroblasts
         Mature Cardiac Fibroblasts Myocardium
 
 Cartilage (Muscoskeletal System)
         Chondrocytes Zeugopod Epiphyseal End
MCOLN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MCOLN2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591446
    Custom PCR Arrays for MCOLN2
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for MCOLN2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCOLN2
QuantiTect SYBR Green Assays in human, mouse, rat MCOLN2
QuantiFast Probe-based Assays in human, mouse, rat MCOLN2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCOLN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MCOLN2 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mcoln21 , 5 mucolipin 21, 5 82.52(n)1
82.58(a)1
  3 (71.03 cM)5
682791  NM_026656.41  NP_080932.21 
 1461498335 
chicken
(Gallus gallus)
Aves MCOLN21 mucolipin 2 75.34(n)
76.01(a)
  424531  XM_422368.4  XP_422368.2 
lizard
(Anolis carolinensis)
Reptilia MCOLN26
mucolipin 2
76(a)
1 ↔ 1
GL343194.1(10043229-10065854)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17072 Xenopus laevis transcribed sequence with weak similarity more 78.55(n)    CF520914.1 
zebrafish
(Danio rerio)
Actinopterygii zgc553102 similar to mucolipin 2 75.44(n)   394123  BC044140.1 
fruit fly
(Drosophila melanogaster)
Insecta CG426386
trpml6
transient receptor potential mucolipin
32(a)
32(a)
many ↔ many
many ↔ many
3L(19738934-19742819)
3L(19707518-19711428)
worm
(Caenorhabditis elegans)
Secernentea cup-56
Protein CUP-5, isoform e (cup-5) mRNA, complete cd...
27(a)
1 → many
III(7584181-7591576) WBGene00000846


ENSEMBL Gene Tree for MCOLN2 (if available)
TreeFam Gene Tree for MCOLN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MCOLN2 gene
MCOLN32  MCOLN12  
2 SIMAP similar genes for MCOLN2 using alignment to 2 protein entries:     MCLN2_HUMAN (see all proteins):
MCOLN3    MCOLN1

MCOLN2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MCOLN2 (see all 1659)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs745958741,2
--85409319(+) TATAGC/TTGGTG 1 -- ds50010--------
rs1858198341,2
--85409405(+) GGAGGA/GCGACT 1 -- ds50010--------
rs1902794361,2
--85409451(+) GGGTCA/CTGCTT 1 -- ds50010--------
rs1441645791,2
--85409567(+) CATCAA/TAAATA 1 -- ds50010--------
rs37385721,2
C,F,A,H--85409608(-) AAGGAT/CATACA 1 -- ds500140Minor allele frequency- C:0.50EA NA NS WA CSA 4877
rs1459948101,2
--85409681(+) TGAATA/GTTTCA 1 -- ds50010--------
rs1399402221,2
--85409839(+) TGACCA/GCTGCT 1 -- ut310--------
rs740987161,2
C,F--85409865(+) ATGTCA/GTGTGT 1 -- ut312Minor allele frequency- G:0.05WA 120
rs785678101,2
F--85409897(+) AGTGAC/TGAGGC 1 -- ut310--------
rs1820483131,2
--85409963(+) TATCAC/TGCTGA 1 -- ut310--------

HapMap Linkage Disequilibrium report for MCOLN2 (85391266 - 85462796 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MCOLN2:    About this table    
Variant IDTypeSubtypePubMed ID
esv267474CNV Insertion20981092
nsv830448CNV Loss17160897
nsv470724CNV Gain18288195
nsv462383CNV Gain19166990

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MCOLN2
DNA2.0 Custom Variant and Variant Library Synthesis for MCOLN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607399    OMIM disorders: --

1 disease for MCOLN2:    
About MalaCards
mucolipidosis

1 disease from the University of Copenhagen DISEASES database for MCOLN2:
Mucolipidosis

MCOLN2 for disorders           About GeneDecksing

Genetic Association Database (GAD): MCOLN2
Human Genome Epidemiology (HuGE) Navigator: MCOLN2 (1 document)

Export disorders for MCOLN2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MCOLN2 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with MCOLN2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. (PubMed id 12403827)1, 2 Di Palma F....Noben-Trauth K. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Functional multimerization of mucolipin channel proteins. (PubMed id 19885840)1, 9 Curcio-Morelli C....Slaugenhaupt S.A. (J. Cell. Physiol. 2010)
  6. Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. (PubMed id 22753890)1 Grimm C....Heller S. (J. Biol. Chem. 2012)
  7. Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy. (PubMed id 20736310)1 Zeevi D.A....Bach G. (J. Cell. Sci. 2010)
  8. Constitutive activity of the human TRPML2 channel induces cell degeneration. (PubMed id 19940139)1 Lev S....Minke B. (J. Biol. Chem. 2010)
  9. The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1. (PubMed id 19763610)1 Samie M.A....Cuajungco M.P. (Pflugers Arch. 2009)
  10. Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs. (PubMed id 17662026)1 Karacsonyi C....Puertollano R. (Traffic 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 255231 HGNC: 13357 AceView: MCOLN2 Ensembl:ENSG00000153898 euGenes: HUgn255231
ECgene: MCOLN2 H-InvDB: MCOLN2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MCOLN2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MCOLN2 gene:
Search GeneIP for patents involving MCOLN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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