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Aliases for MCMDC2 Gene

Aliases for MCMDC2 Gene

  • Minichromosome Maintenance Domain Containing 2 2 3 5
  • C8orf45 3 4
  • MCM Domain-Containing Protein C8orf45 3
  • Chromosome 8 Open Reading Frame 45 2

External Ids for MCMDC2 Gene

Previous HGNC Symbols for MCMDC2 Gene

  • C8orf45

Previous GeneCards Identifiers for MCMDC2 Gene

  • GC08P067783

Summaries for MCMDC2 Gene

GeneCards Summary for MCMDC2 Gene

MCMDC2 (Minichromosome Maintenance Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCMDC2 Gene

Genomics for MCMDC2 Gene

Regulatory Elements for MCMDC2 Gene

Promoters for MCMDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MCMDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCMDC2 Gene

Chromosome:
8
Start:
66,870,749 bp from pter
End:
66,926,386 bp from pter
Size:
55,638 bases
Orientation:
Plus strand

Genomic View for MCMDC2 Gene

Genes around MCMDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCMDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCMDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCMDC2 Gene

Proteins for MCMDC2 Gene

  • Protein details for MCMDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0Z9-MCMD2_HUMAN
    Recommended name:
    MCM domain-containing protein 2
    Protein Accession:
    Q4G0Z9
    Secondary Accessions:
    • B4DYZ3
    • B4DZM4
    • B4E293
    • Q6P533
    • Q7Z3P4

    Protein attributes for MCMDC2 Gene

    Size:
    681 amino acids
    Molecular mass:
    76219 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34576.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH63108.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MCMDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCMDC2 Gene

Proteomics data for MCMDC2 Gene at MOPED

Post-translational modifications for MCMDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCMDC2 Gene

No data available for DME Specific Peptides for MCMDC2 Gene

Domains & Families for MCMDC2 Gene

Gene Families for MCMDC2 Gene

Protein Domains for MCMDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCMDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0Z9

UniProtKB/Swiss-Prot:

MCMD2_HUMAN :
  • Contains 1 MCM domain.
Domain:
  • Contains 1 MCM domain.
genes like me logo Genes that share domains with MCMDC2: view

Function for MCMDC2 Gene

Gene Ontology (GO) - Molecular Function for MCMDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MCMDC2: view
genes like me logo Genes that share phenotypes with MCMDC2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCMDC2 Gene

Localization for MCMDC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCMDC2 Gene COMPARTMENTS Subcellular localization image for MCMDC2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MCMDC2 Gene

Pathways & Interactions for MCMDC2 Gene

SuperPathways for MCMDC2 Gene

No Data Available

Interacting Proteins for MCMDC2 Gene

Gene Ontology (GO) - Biological Process for MCMDC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MCMDC2 Gene

Drugs & Compounds for MCMDC2 Gene

No Compound Related Data Available

Transcripts for MCMDC2 Gene

Unigene Clusters for MCMDC2 Gene

Minichromosome maintenance domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCMDC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for MCMDC2 Gene

GeneLoc Exon Structure for
MCMDC2
ECgene alternative splicing isoforms for
MCMDC2

Expression for MCMDC2 Gene

mRNA expression in normal human tissues for MCMDC2 Gene

mRNA differential expression in normal tissues according to GTEx for MCMDC2 Gene

This gene is overexpressed in Testis (x5.8).

SOURCE GeneReport for Unigene cluster for MCMDC2 Gene Hs.437006

genes like me logo Genes that share expression patterns with MCMDC2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MCMDC2 Gene

Orthologs for MCMDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCMDC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCMDC2 35
  • 91.87 (n)
  • 90.9 (a)
MCMDC2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCMDC2 35
  • 91.39 (n)
  • 90.01 (a)
MCMDC2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcmdc2 35
  • 86.74 (n)
  • 85.46 (a)
Mcmdc2 16
Mcmdc2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCMDC2 35
  • 99.56 (n)
  • 99.41 (a)
MCMDC2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcmdc2 35
  • 86.1 (n)
  • 84.88 (a)
oppossum
(Monodelphis domestica)
Mammalia MCMDC2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCMDC2 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8ORF45 35
  • 70.08 (n)
  • 65.58 (a)
MCMDC2 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100150056 35
  • 58.17 (n)
  • 51.58 (a)
MCMDC2 36
  • 51 (a)
OneToOne
Species with no ortholog for MCMDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCMDC2 Gene

ENSEMBL:
Gene Tree for MCMDC2 (if available)
TreeFam:
Gene Tree for MCMDC2 (if available)

Paralogs for MCMDC2 Gene

No data available for Paralogs for MCMDC2 Gene

Variants for MCMDC2 Gene

Sequence variations from dbSNP and Humsavar for MCMDC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs16933088 - 66,877,473(+) TGCAA(A/T)GACAA intron-variant, reference, missense
rs17332410 - 66,883,885(+) ATTTG(C/G)TCAAG reference, missense
rs11778562 - 66,901,326(+) AGCTG(G/T)CAGCA reference, missense
rs2195702 -- 66,891,086(-) AATTT(A/T)AAAAA intron-variant
rs2358008 -- 66,901,398(+) ATGAT(A/G)TGTTT intron-variant, utr-variant-3-prime

Variation tolerance for MCMDC2 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.70; 83.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCMDC2 Gene

HapMap Linkage Disequilibrium report
MCMDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCMDC2 Gene

Disorders for MCMDC2 Gene

Relevant External Links for MCMDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCMDC2

No disorders were found for MCMDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCMDC2 Gene

Publications for MCMDC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MCMDC2 Gene

Sources for MCMDC2 Gene

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