MCMDC2 Gene
protein-coding GIFtS: 35
GCID: GC08P067783
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|
minichromosome maintenance domain containing 2(Previous name: chromosome 8 open reading frame 45 )
(Previous symbol: C8orf45)
| |
Aliases
for MCMDC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Minichromosome Maintenance Domain Containing 21 2 | | C8orf451 2 3 | | FLJ256921 | | Chromosome 8 Open Reading Frame 451 | | MCM Domain-Containing Protein 22 | | MCM Domain-Containing Protein C8orf452 |
Export aliases for MCMDC2 gene to outside databases |
Summaries
for MCMDC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MCMDC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MCMDC2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MCMDC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCMDC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.1 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q13.1MCMDC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P067783: view genomic region
(about GC identifiers)
Start:
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67,782,984 bp from pter |
End:
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67,834,283 bp from pter |
Size:
|
51,300 bases |
Orientation:
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plus strand |
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Proteins
for MCMDC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MCMD2_HUMAN, Q4G0Z9 (See
protein sequence)Recommended Name: MCM domain-containing protein 2 Size: 681 amino acids; 76219 Da
Sequence caution: Sequence=AAH34576.2; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH63108.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DYZ3 B4DZM4 B4E293 Q6P533 Q7Z3P4Alternative splicing: 4 isoforms: Q4G0Z9-1 Q4G0Z9-2 Q4G0Z9-3 Q4G0Z9-4 Explore the universe of human proteins at neXtProt for MCMDC2: NX_Q4G0Z9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4G0Z9
MCMDC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001129632.1 NP_001129633.1 NP_775789.3
ENSEMBL proteins: ENSP00000379837 ENSP00000413632 ENSP00000416848 ENSP00000428037 ENSP00000317234 ENSP00000395867 ENSP00000445629
Human Recombinant Protein Products for MCMDC2:
MCMDC2 Antibody Products:
Assay Products for MCMDC2: |
Protein
Domains /
Families
for MCMDC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MCMDC2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4G0Z9ProtoNet protein and cluster: Q4G0Z9 UniProtKB/Swiss-Prot: MCMD2_HUMAN, Q4G0Z9Similarity: Contains 1 MCM domain |
Function
for MCMDC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MCMDC2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCMDC2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCMDC2 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for MCMDC2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCMDC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCMDC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCMDC2 |
|
Pathways & Interactions
for MCMDC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MCMDC2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006260 | DNA replication |
IEA | -- |
MCMDC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MCMDC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MCMDC2
Search CenterWatch for drugs/clinical trials and news about MCMDC2 / MCMD2
|
Transcripts
for MCMDC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MCMDC2 gene (3 alternative transcripts): NM_001136160.1 NM_001136161.1 NM_173518.4 Unigene Cluster for MCMDC2: Minichromosome maintenance domain containing 2 Hs.437006 [show with all ESTs]Unigene Representative Sequence: NM_1735188 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396592(uc011lev.2) ENST00000422365(uc003xwz.4 uc011lew.2 uc011lex.2)
ENST00000428734 ENST00000492775(uc003xwv.3) ENST00000469823 ENST00000313616(uc003xwy.4)
ENST00000415737 ENST00000541540
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCMDC2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCMDC2 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MCMDC2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCMDC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCMDC2 |
Additional cDNA sequence: AK098558.1 AK302169.1 AK302672.1 AK304170.1 AL833526.1 BC034576.1 BC063108.1 BX537587.1 5 DOTS entries: DT.101972477 DT.97803255 DT.104664 DT.101956419 DT.40226905 24 AceView cDNA sequences: AA349871 AA349870 BC063108 AW264899 AI017591 BG722401 CD244299 AI123287 AW103148 AW269810 BX537587 BC034576 AL833526 BX281704 BI828965 NM_173518 BX117671 AA928149 AK098558 BG537678 BI851005 BU679985 BU657855 AA652791
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MCMDC2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 |
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| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MCMDC2
|
Expression
for MCMDC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See MCMDC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCMDC2
SOURCE GeneReport for Unigene cluster: Hs.437006
SABiosciences Custom PCR Arrays for MCMDC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCMDC2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MCMDC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCMDC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCMDC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCMDC2 |
Orthologs
for MCMDC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MCMDC2 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for MCMDC2 (if available)
TreeFam Gene Tree for MCMDC2 (if available) |
Paralogs
for MCMDC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MCMDC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MCMDC2 (67782984 - 67834283 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MCMDC2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCMDC2 |
|
Disorders
/ Diseases
for MCMDC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MCMDC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MCMDC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MCMDC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MCMDC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MCMDC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MCMDC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MCMDC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MCMDC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MCMDC2 gene:
Search GeneIP for patents involving MCMDC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MCMDC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MCMDC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCMDC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCMDC2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MCMDC2 | | OriGene 3'-UTR Clone for MCMDC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCMDC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCMDC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MCMDC2 | | OriGene Custom Protein Services for MCMDC2 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MCMDC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCMDC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCMDC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCMDC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCMDC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCMDC2 |
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 |  |  |  | |
| | | | Search Tocris compounds for MCMDC2 |
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 | | | MCMDC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCMDC2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MCMDC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCMDC2 |
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