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Aliases for MCMDC2 Gene

Aliases for MCMDC2 Gene

  • Minichromosome Maintenance Domain Containing 2 2 3
  • C8orf45 3 4
  • MCM Domain-Containing Protein C8orf45 3
  • Chromosome 8 Open Reading Frame 45 2
  • MCM Domain-Containing Protein 2 3

External Ids for MCMDC2 Gene

Previous HGNC Symbols for MCMDC2 Gene

  • C8orf45

Previous GeneCards Identifiers for MCMDC2 Gene

  • GC08P067783

Summaries for MCMDC2 Gene

GeneCards Summary for MCMDC2 Gene

MCMDC2 (Minichromosome Maintenance Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCMDC2 Gene

Genomics for MCMDC2 Gene

Genomic Location for MCMDC2 Gene

66,870,749 bp from pter
66,922,048 bp from pter
51,300 bases
Plus strand

Genomic View for MCMDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCMDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCMDC2 Gene

No data available for Regulatory Elements for MCMDC2 Gene

Proteins for MCMDC2 Gene

  • Protein details for MCMDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MCM domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DYZ3
    • B4DZM4
    • B4E293
    • Q6P533
    • Q7Z3P4

    Protein attributes for MCMDC2 Gene

    681 amino acids
    Molecular mass:
    76219 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34576.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH63108.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MCMDC2 Gene


neXtProt entry for MCMDC2 Gene

Proteomics data for MCMDC2 Gene at MOPED

Post-translational modifications for MCMDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCMDC2 Gene

No data available for DME Specific Peptides for MCMDC2 Gene

Domains for MCMDC2 Gene

Gene Families for MCMDC2 Gene

Protein Domains for MCMDC2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MCM domain.
  • Contains 1 MCM domain.
genes like me logo Genes that share domains with MCMDC2: view

No data available for Suggested Antigen Peptide Sequences for MCMDC2 Gene

Function for MCMDC2 Gene

Gene Ontology (GO) - Molecular Function for MCMDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MCMDC2: view

Animal Model Products

miRNA for MCMDC2 Gene

miRTarBase miRNAs that target MCMDC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MCMDC2 Gene

Localization for MCMDC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MCMDC2 Gene

Pathways for MCMDC2 Gene

SuperPathways for MCMDC2 Gene

No Data Available

Interacting Proteins for MCMDC2 Gene

Gene Ontology (GO) - Biological Process for MCMDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
genes like me logo Genes that share ontologies with MCMDC2: view

No data available for Pathways by source for MCMDC2 Gene

Transcripts for MCMDC2 Gene

Unigene Clusters for MCMDC2 Gene

Minichromosome maintenance domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCMDC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCMDC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for MCMDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MCMDC2 Gene

mRNA expression in normal human tissues for MCMDC2 Gene

mRNA differential expression in normal tissues according to GTEx for MCMDC2 Gene

This gene is overexpressed in Testis (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MCMDC2 Gene

SOURCE GeneReport for Unigene cluster for MCMDC2 Gene Hs.437006

genes like me logo Genes that share expressions with MCMDC2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for MCMDC2 Gene

Orthologs for MCMDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCMDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MCMDC2 35
  • 91.87 (n)
  • 90.9 (a)
  • 91 (a)
(Canis familiaris)
Mammalia MCMDC2 35
  • 91.39 (n)
  • 90.01 (a)
  • 89 (a)
(Mus musculus)
Mammalia Mcmdc2 35
  • 86.74 (n)
  • 85.46 (a)
Mcmdc2 16
Mcmdc2 36
  • 85 (a)
(Pan troglodytes)
Mammalia MCMDC2 35
  • 99.56 (n)
  • 99.41 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mcmdc2 35
  • 86.1 (n)
  • 84.88 (a)
(Monodelphis domestica)
Mammalia MCMDC2 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia MCMDC2 36
  • 73 (a)
(Gallus gallus)
Aves C8ORF45 35
  • 70.08 (n)
  • 65.58 (a)
  • 65 (a)
(Danio rerio)
Actinopterygii LOC100150056 35
  • 58.17 (n)
  • 51.58 (a)
  • 51 (a)
Species with no ortholog for MCMDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCMDC2 Gene

Gene Tree for MCMDC2 (if available)
Gene Tree for MCMDC2 (if available)

Paralogs for MCMDC2 Gene

No data available for Paralogs for MCMDC2 Gene

Variants for MCMDC2 Gene

Sequence variations from dbSNP and Humsavar for MCMDC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2195702 -- 66,891,086(-) AATTT(A/T)AAAAA intron-variant
rs2358008 -- 66,901,398(+) ATGAT(A/G)TGTTT intron-variant, utr-variant-3-prime
rs4540395 -- 66,886,815(+) tttcc(A/G)aagtg intron-variant
rs4737815 -- 66,891,293(+) AATGG(A/T)CCAGA intron-variant
rs5892068 -- 66,915,910(+) AAGAA(-/A)TGAGA intron-variant

Relevant External Links for MCMDC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCMDC2 Gene

Disorders for MCMDC2 Gene

No disorders were found for MCMDC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MCMDC2 Gene

Publications for MCMDC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4

Products for MCMDC2 Gene

Sources for MCMDC2 Gene

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