Aliases for MCMBP Gene
Aliases for MCMBP Gene
External Ids for MCMBP Gene
- HGNC: 25782
- Entrez Gene: 79892
- Ensembl: ENSG00000197771
- OMIM: 610909
- UniProtKB: Q9BTE3
Previous HGNC Symbols for MCMBP Gene
- C10orf119
Previous GeneCards Identifiers for MCMBP Gene
- GC10M121588
Summaries for MCMBP Gene
-
This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for MCMBP Gene
MCMBP (Minichromosome Maintenance Complex Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot for MCMBP Gene
-
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCMBP Gene
Genomics for MCMBP Gene
GeneHancer (GH) Regulatory Elements for MCMBP Gene
Regulatory Element Products
Genomic Locations for MCMBP Gene
- chr10:119,829,404-119,892,556
- (GRCh38/hg38)
- Size:
- 63,153 bases
- Orientation:
- Minus strand
- chr10:121,588,972-121,652,068
- (GRCh37/hg19)
Genomic View for MCMBP Gene
- Cytogenetic band:
-
- 10q26.11 by Ensembl
- 10q26.11 by Entrez Gene
- 10q26.11 by HGNC


RefSeq DNA sequence for MCMBP Gene
Proteins for MCMBP Gene
-
Protein details for MCMBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BTE3-MCMBP_HUMAN
- Recommended name:
- Mini-chromosome maintenance complex-binding protein
- Protein Accession:
- Q9BTE3
- B3KSP7
- Q6IA56
- Q9BVT9
- Q9H916
Protein attributes for MCMBP Gene
- Size:
- 642 amino acids
- Molecular mass:
- 72980 Da
- Quaternary structure:
-
- Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone.
Protein Expression for MCMBP Gene
Post-translational modifications for MCMBP Gene
- Ubiquitination at posLast=4747, isoforms=261, posLast=6767, posLast=142142, isoforms=2, 3314, isoforms=2, 3388, posLast=431431, posLast=582582, isoforms=2, 3621, isoforms=2, 3635, and posLast=332332
Other Protein References for MCMBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MCMBP
- Novus Biologicals Antibodies for MCMBP
- Invitrogen Antibodies for MCMBP
- GeneTex MCMBP antibody for MCMBP
Protein Products
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- Search GeneTex for Proteins for MCMBP
Assay Products
No data available for DME Specific Peptides for MCMBP Gene
Domains & Families for MCMBP Gene
Gene Families for MCMBP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MCMBP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MCMBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BTE3- Family:
-
- Belongs to the MCMBP family.
Function for MCMBP Gene
Molecular function for MCMBP Gene
- UniProtKB/Swiss-Prot Function:
- Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IDA | 17296731 |
GO:0005515 | protein binding | IPI | 17296731 |
Phenotypes for MCMBP Gene
- GenomeRNAi human phenotypes for MCMBP:
Animal Model Products
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-
-
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CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for MCMBP Gene
- miRTarBase miRNAs that target MCMBP
-
- hsa-mir-340-5p (MIRT019649)
- hsa-mir-34a-5p (MIRT025386)
- hsa-mir-26b-5p (MIRT029372)
- hsa-mir-342-5p (MIRT038205)
- hsa-mir-551b-3p (MIRT040523)
- hsa-mir-423-3p (MIRT042503)
- hsa-mir-365a-3p (MIRT044035)
- hsa-mir-4427 (MIRT536039)
- hsa-mir-545-5p (MIRT536040)
- hsa-mir-487a-3p (MIRT536041)
- hsa-mir-154-3p (MIRT536042)
- hsa-mir-4724-5p (MIRT536043)
- hsa-mir-570-5p (MIRT536044)
- hsa-mir-548ba (MIRT536045)
- hsa-mir-548ai (MIRT536046)
- hsa-mir-548ag (MIRT536047)
- hsa-mir-6507-3p (MIRT536048)
- hsa-mir-548t-5p (MIRT536049)
- hsa-mir-548az-5p (MIRT536050)
- hsa-mir-548n (MIRT536051)
- hsa-mir-1257 (MIRT722721)
- hsa-mir-6809-5p (MIRT722722)
- hsa-mir-31-5p (MIRT722723)
- hsa-mir-15b-3p (MIRT722724)
- hsa-mir-3607-5p (MIRT722725)
- hsa-mir-7852-3p (MIRT722726)
- hsa-mir-5197-5p (MIRT722727)
miRNA Products
- Search ViGene Biosciences for MCMBP
Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MCMBP gene related products
- orf clones - Search results for available MCMBP gene related products
- Applied Biological Materials Clones for MCMBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MCMBP gene
-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCMBP Gene
Localization for MCMBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCMBP Gene
- Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IBA | -- |
GO:0005634 | nucleus | IDA,IEA | 17296731 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for MCMBP Gene
Interacting Proteins for MCMBP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006260 | DNA replication | IEA | -- |
GO:0006261 | DNA-dependent DNA replication | IMP | 21196493 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007062 | sister chromatid cohesion | IMP | 20090939 |
GO:0051301 | cell division | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MCMBP Gene
Transcripts for MCMBP Gene
mRNA/cDNA for MCMBP Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (301) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MCMBP Gene
CRISPR Products
-
OriGene CRISPR knockouts for MCMBP
- genomics-online: gRNA clones - Search results for available MCMBP gene related products
- Applied Biological Materials CRISPR for MCMBP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCMBP
- GenScript: Design CRISPR guide RNA sequences for MCMBP
miRNA Products
- Search ViGene Biosciences for MCMBP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MCMBP
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- genomics-online: shRNA clones - Search results for available MCMBP gene related products
-
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MCMBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MCMBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MCMBP gene related products
- orf clones - Search results for available MCMBP gene related products
- Applied Biological Materials Clones for MCMBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · |
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SP7: |
ExUns: | 17b |
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SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: | |
SP6: | |
SP7: |
Expression for MCMBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCMBP Gene
NURSA nuclear receptor signaling pathways regulating expression of MCMBP Gene:
MCMBPSOURCE GeneReport for Unigene cluster for MCMBP Gene:
Hs.124246Evidence on tissue expression from TISSUES for MCMBP Gene
- Liver(4.2)
- Muscle(4.2)
- Nervous system(3.2)
Primer Products
-
OriGene qPCR primer pairs for MCMBP
-
OriGene qPCR primer pairs and template standards for MCMBP
- genomics-online: primer clones - Search results for available MCMBP gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCMBP Gene
Orthologs for MCMBP Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MCMBP 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
C10ORF119 34 |
|
OneToMany | |||
MCMBP 33 |
|
||||
cow (Bos Taurus) |
Mammalia | MCMBP 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | MCMBP 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | MCMBP 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | RGD1306730 33 |
|
||
mouse (Mus musculus) |
Mammalia | Mcmbp 33 16 34 |
|
||
chicken (Gallus gallus) |
Aves | MCMBP 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | MCMBP 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | mcmbp 33 |
|
||
Str.19983 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | flj13081-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | mcmbp 33 34 |
|
||
Dr.4989 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6706 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG3430 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011536 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | ETG1 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os01g0166800 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MCMBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MCMBP Gene
No data available for Paralogs for MCMBP Gene
Variants for MCMBP Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000007053 | -- | 119,866,734(-) | T/A | intron_variant | |
rs1000099148 | -- | 119,866,347(-) | C/T | intron_variant | |
rs1000161336 | -- | 119,872,208(-) | C/G | intron_variant | |
rs1000227831 | -- | 119,866,433(-) | C/G | intron_variant | |
rs1000238337 | -- | 119,840,581(-) | G/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2858458 | CNV | duplication | 24192839 |
esv3302887 | CNV | tandem duplication | 20981092 |
esv3344248 | CNV | insertion | 20981092 |
esv3421920 | CNV | insertion | 20981092 |
nsv1045668 | CNV | gain | 25217958 |
nsv1121822 | CNV | deletion | 24896259 |
nsv7571 | CNV | insertion | 18451855 |
Additional Variant Information for MCMBP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MCMBP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCMBP Gene
Disorders for MCMBP Gene
Additional Disease Information for MCMBP
No disorders were found for MCMBP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCMBP Gene
Publications for MCMBP Gene
- Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe AM … Frappier L (Molecular and cellular biology 2007) 2 3 4 58
- MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. (PMID: 21196493) Nishiyama A … Méchali M (Genes & development 2011) 3 4 58
- The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. (PMID: 20090939) Takahashi N … De Veylder L (PLoS genetics 2010) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for MCMBP Gene
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- Invitrogen Antibodies for MCMBP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for MCMBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MCMBP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 22 available MCMBP Antibodies ranked by validation data
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- antibodies-online: Search results for 3 available MCMBP Proteins ranked by validation data
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- GeneTex MCMBP antibody for MCMBP
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- ViGene Biosciences adenoviral particle packaged cDNA for MCMBP gene
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- Search ViGene Biosciences for MCMBP
- genomics-online: cdna clones - Search results for available MCMBP gene related products
- orf clones - Search results for available MCMBP gene related products
- genomics-online: gRNA clones - Search results for available MCMBP gene related products
- genomics-online: primer clones - Search results for available MCMBP gene related products
- genomics-online: shRNA clones - Search results for available MCMBP gene related products
Sources for MCMBP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
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