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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCMBP Gene

protein-coding GIFtS: 47
GCID: GC10M121588

Minichromosome Maintenance Complex Binding Protein

(Previous name: chromosome 10 open reading frame 119)
(Previous symbol: C10orf119)

Alzheimer's & Parkinson's Diseases Congress

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Binding Protein¹ ²		Chromosome 10 Open Reading Frame 119¹
C10orf119¹ ² ³ ⁵		Mini-Chromosome Maintenance Complex-Binding Protein²
MCM-BP² ³		Minichromosome Maintenance Complex-Binding Protein²
MCM-Binding Protein² ³

External Ids:	HGNC: 25782¹	Entrez Gene: 79892²	Ensembl: ENSG00000197771⁷	OMIM: 610909⁵	UniProtKB: Q9BTE3³

Export aliases for MCMBP gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCMBP Gene:

This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which

regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for MCMBP Gene:

MCMBP (minichromosome maintenance complex binding protein) is a protein-coding gene. Diseases associated with MCMBP include alzheimer's disease. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot: MCMBP_HUMAN, Q9BTE3

Function: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM

complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a

key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex

without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM

complex. Required for sister chromatid cohesion

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NT_030059.13 NC_018921.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MCMBP
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MCMBP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCMBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q26.13

MCMBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCMBP gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M121588: view genomic region (about GC identifiers)

Start:	121,588,972 bp from pter	End:	121,652,068 bp from pter
Size:	63,097 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCMBP_HUMAN, Q9BTE3 (See protein sequence)

Recommended Name: Mini-chromosome maintenance complex-binding protein

Size: 642 amino acids; 72980 Da

Subunit: Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not

interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when

composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone

Subcellular location: Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S

phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates

with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex

Secondary accessions: B3KSP7 Q6IA56 Q9BVT9 Q9H916

Alternative splicing: 3 isoforms: Q9BTE3-1 Q9BTE3-2 Q9BTE3-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCMBP: NX_Q9BTE3

Explore proteomics data for MCMBP at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9BTE3

MCMBP Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001243307.1 NP_001243308.1 NP_079110.1

ENSEMBL proteins:

ENSP00000353098 ENSP00000358073

Human Recombinant Protein Products for MCMBP:

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--
GO:0042555	colocalizes with MCM complex	IDA	17296731

MCMBP for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR019140 MCM_complex-bd

Graphical View of Domain Structure for InterPro Entry Q9BTE3

ProtoNet protein and cluster: Q9BTE3

UniProtKB/Swiss-Prot: MCMBP_HUMAN, Q9BTE3

Similarity: Belongs to the MCMBP family

MCMBP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MCMBP_HUMAN, Q9BTE3

Function: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM

complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a

key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex

without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM

complex. Required for sister chromatid cohesion

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IDA	17296731

MCMBP for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MCMBP:

Increased gamma-H2AX phosphory

Animal Models:

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		hsa-miR-29a hsa-miR-570 hsa-miR-3142 hsa-miR-9 hsa-miR-889 hsa-miR-330-3p hsa-miR-3163 hsa-miR-601

		SwitchGear 3'UTR luciferase reporter plasmid: MCMBP 3' UTR sequence

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MCMBP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/15 Interacting proteins for MCMBP (Q9BTE3^{2, 3} ENSP00000353098⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDIT3	P35638²^,³, ENSP00000340671⁴	MINT-67504 I2D: score=5 STRING: ENSP00000340671
MCM5	P33992³, ENSP00000216122⁴	I2D: score=6 STRING: ENSP00000216122
TECPR1	Q7Z6L1³, ENSP00000404923⁴	I2D: score=3 STRING: ENSP00000404923
KEAP1	Q14145³, ENSP00000171111⁴	I2D: score=2 STRING: ENSP00000171111
MCM3	P25205³, ENSP00000229854⁴	I2D: score=1 STRING: ENSP00000229854

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000084	S phase of mitotic cell cycle	TAS	17296731
GO:0006261	DNA-dependent DNA replication	IMP	--
GO:0007062	sister chromatid cohesion	IMP	--
GO:0007067	mitosis	IEA	--
GO:0051301	cell division	IEA	--

MCMBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCMBP

Search CenterWatch for drugs/clinical trials and news about MCMBP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCMBP gene (3 alternative transcripts):

NM_001256378.1 NM_001256379.1 NM_024834.3

Unigene Cluster for MCMBP:

Minichromosome maintenance complex binding protein

Hs.124246 [show with all ESTs]

Unigene Representative Sequence: NM_024834

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000360003(uc001leq.1 uc001ler.2 uc001les.1) ENST00000369077

ENST00000466047 ENST00000495407(uc001let.1) ENST00000569515

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCMBP
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate MCMBP (see all 47):
		hsa-miR-29a hsa-miR-570 hsa-miR-3142 hsa-miR-9 hsa-miR-889 hsa-miR-330-3p hsa-miR-3163 hsa-miR-601

		SwitchGear 3'UTR luciferase reporter plasmid: MCMBP 3' UTR sequence

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Additional mRNA sequence:

AK001928.1 AK023143.1 AK094075.1 BC000935.2 BC004183.2 BC007219.1 CR457299.1

12 DOTS entries:

DT.95174649 DT.455894 DT.99994077 DT.100792020 DT.100792019 DT.40107482 DT.101978008 DT.91986611

DT.100792024 DT.92439730 DT.97799962 DT.97846578

24/301 AceView cDNA sequences (see all 301):

BM833408 AA349432 AA310489 AI440138 AA973972 BQ929053 BM930606 N66098

BE465947 AI278309 AI434568 CA430700 AI668846 BU618658 BQ446920 CA424638

BC000935 BP378958 NM_024834 BM807043 AI917203 BG528848 BQ231534 AI631297

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MCMBP (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17a	·
SP1:			-								-		-				-		-				-										-												-
SP2:											-		-										-										-												-
SP3:											-		-										-										-												-
SP4:																							-
SP5:

ExUns:	17b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MCMBP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCMBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGCTTTTGA

About this image

See MCMBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCMBP

SOURCE GeneReport for Unigene cluster: Hs.124246

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCMBP gene from 8/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mcmbp^{1 , 5}	MCM (minichromosome maintenance deficient) binding more^{1, 5}	85.25(n)¹ 92.99(a)¹		7 (70.41 cM)⁵ 210711¹ NM_145955.3¹ NP_666067.1¹ 128696441⁵
chicken (Gallus gallus)	Aves	MCMBP¹	minichromosome maintenance complex binding protein	79.39(n) 84.07(a)		423933 NM_001012912.1 NP_001012930.1
lizard (Anolis carolinensis)	Reptilia	MCMBP⁶	Uncharacterized protein	80(a)	1 ↔ 1	3(66170104-66205716)
African clawed frog (Xenopus laevis)	Amphibia	flj13081-prov²	hypothetical protein MGC52627	75.96(n)		BC042336.1
zebrafish (Danio rerio)	Actinopterygii	Dr.4989²	Danio rerio mRNA similar to hypothetical protein FLJ13 more	73.61(n)		BC044562.1
fruit fly (Drosophila melanogaster)	Insecta	CG3430¹	CG3430	46.63(n) 38.83(a)		33976 NM_080707.3 NP_542438.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ETG1¹	E2F target protein 1	45.55(n) 36.11(a)		818650 NM_129617.4 NP_181587.2
rice (Oryza sativa)	Liliopsida	Os01g0166800¹	hypothetical protein	44.99(n) 33.57(a)		4327146 NM_001048653.1 NP_001042118.1

ENSEMBL Gene Tree for MCMBP (if available)
TreeFam Gene Tree for MCMBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192246187^1,2		--	121589210(+)	`TCAGCG/TCTCTC`	3	--	ut3¹		0	--	--	--	--
rs184635011^1,2		--	121589234(+)	`AGAGGA/GCATGG`	3	--	ut3¹		0	--	--	--	--
rs150170679^1,2		--	121589254(+)	`ACACAA/GATCAC`	3	--	ut3¹		0	--	--	--	--
rs145602296^1,2	C	--	121589264(+)	`CATGGC/GATGGT`	3	--	ut3¹		0	--	--	--	--
rs41287946^1,2	C,F	--	121589274(+)	`TGAATC/ATTCTT`	3	--	ut3¹		5		NA WA CSA	243
rs140254464^1,2		--	121589366(+)	`AAGACC/TAAGCA`	3	--	ut3¹		0	--	--	--	--
rs189299215^1,2		--	121589375(+)	`CAATGC/TATGTA`	3	--	ut3¹		0	--	--	--	--
rs6881^1,2	C,F,A,H	--	121589402(-)	`TGTAAC/ATTGTA`	3	--	ut3¹		13		MN NS EA NA WA	1038
rs145233973^1,2	C	--	121589427(+)	`ACATGA/GTGACT`	3	--	ut3¹		0	--	--	--	--
rs14085^1,2	C,F	--	121589576(+)	`TAAACA/CTTATT`	3	--	ut3¹		2		MN WA	186

HapMap Linkage Disequilibrium report for MCMBP (121588972 - 121652068 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for MCMBP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv7571	CNV	Insertion	18451855
nsv896044	CNV	Gain	21882294
esv259861	OTHER	Complex	20981092

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 610909 OMIM disorders: --

2 diseases for MCMBP: About MalaCards

alzheimer's disease

MCMBP for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Export disorders for MCMBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MCMBP gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with MCMBP)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)^{1, 2, 3} Sakwe A.M....Frappier L. (2007)
MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. (PubMed id 21196493)^{1, 2} Nishiyama A.... Mechali M. (2011)
The MCM-binding protein ETG1 aids sister chromatid co hesion required for postreplicative homologous recombination repair. (PubMed id 20090939)^{1, 2} Takahashi N....De Veylder L. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
The MCM-associated protein MCM-BP is important for hum an nuclear morphology. (PubMed id 22250201)¹ Jagannathan M....Frappier L. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79892	HGNC: 25782	AceView: C10orf119	Ensembl:ENSG00000197771	euGenes: HUgn79892
ECgene: MCMBP	H-InvDB: MCMBP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Minichromosome Maintenance Complex Binding Protein

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