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MCMBP Gene

protein-coding   GIFtS: 49
GCID: GC10M121588

Minichromosome Maintenance Complex Binding Protein

(Previous name: chromosome 10 open reading frame 119)
(Previous symbol: C10orf119)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Minichromosome Maintenance Complex Binding Protein1 2     Chromosome 10 Open Reading Frame 1191
C10orf1191 2 3 5     Mini-Chromosome Maintenance Complex-Binding Protein2
MCM-BP2 3     Minichromosome Maintenance Complex-Binding Protein2
MCM-Binding Protein2 3     

External Ids:    HGNC: 257821   Entrez Gene: 798922   Ensembl: ENSG000001977717   OMIM: 6109095   UniProtKB: Q9BTE33   

Export aliases for MCMBP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MCMBP Gene:
This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which
regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for MCMBP Gene:
MCMBP (minichromosome maintenance complex binding protein) is a protein-coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot: MCMBP_HUMAN, Q9BTE3
Function: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM
complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a
key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex
without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM
complex. Required for sister chromatid cohesion




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MCMBP
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MCMBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCMBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.13

MCMBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCMBP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M121588:  view genomic region     (about GC identifiers)

Start:
121,588,972 bp from pter      End:
121,652,068 bp from pter
Size:
63,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCMBP_HUMAN, Q9BTE3 (See protein sequence)
Recommended Name: Mini-chromosome maintenance complex-binding protein  
Size: 642 amino acids; 72980 Da
Subunit: Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not
interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when
composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone
1 PDB 3D structure from and Proteopedia for MCMBP:
4KG9 (3D)    
Secondary accessions: B3KSP7 Q6IA56 Q9BVT9 Q9H916
Alternative splicing: 3 isoforms:  Q9BTE3-1   Q9BTE3-2   Q9BTE3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCMBP: NX_Q9BTE3

Explore proteomics data for MCMBP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47, Lys61, Lys67, Lys142, Lys314, Lys388, Lys431, Lys582, Lys621, Lys635
  • Modification sites at PhosphoSitePlus

  • See MCMBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243307.1  NP_001243308.1  NP_079110.1  

    ENSEMBL proteins: 
     ENSP00000353098   ENSP00000358073  

    MCMBP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MCMBP

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019140 MCM_complex-bd

    Graphical View of Domain Structure for InterPro Entry Q9BTE3

    ProtoNet protein and cluster: Q9BTE3

    UniProtKB/Swiss-Prot: MCMBP_HUMAN, Q9BTE3
    Similarity: Belongs to the MCMBP family


    Find genes that share domains with MCMBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCMBP_HUMAN, Q9BTE3
    Function: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM
    complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a
    key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex
    without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM
    complex. Required for sister chromatid cohesion

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA17296731
    GO:0005515protein binding IPI17296731
         
    Find genes that share ontologies with MCMBP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MCMBP:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target MCMBP:
    hsa-mir-551b-3p (MIRT040523), hsa-mir-34a-5p (MIRT025386), hsa-mir-423-3p (MIRT042503), hsa-mir-340-5p (MIRT019649), hsa-mir-26b-5p (MIRT029372), hsa-mir-365a-3p (MIRT044035), hsa-mir-342-5p (MIRT038205)

    Block miRNA regulation of human, mouse, rat MCMBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCMBP (see all 47):
    hsa-miR-29a hsa-miR-570 hsa-miR-3142 hsa-miR-9 hsa-miR-889 hsa-miR-330-3p hsa-miR-3163 hsa-miR-601
    SwitchGear 3'UTR luciferase reporter plasmidMCMBP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCMBP_HUMAN, Q9BTE3: Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S
    phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates
    with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0042555colocalizes with MCM complex IDA17296731

    Find genes that share ontologies with MCMBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MCMBP
    Interactions:

        Search GeneGlobe Interaction Network for MCMBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MCMBP (Q9BTE31, 2, 3 ENSP000003530984) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM5P339921, 3, ENSP000002161224EBI-749378,EBI-359410 I2D: score=6 STRING: ENSP00000216122
    MCM3P252051, 3, ENSP000002298544EBI-749378,EBI-355153 I2D: score=1 STRING: ENSP00000229854
    MCM4P339911, 3, ENSP000002621054EBI-749378,EBI-374938 I2D: score=1 STRING: ENSP00000262105
    MCM6Q145661, 3, ENSP000002641564EBI-749378,EBI-374900 I2D: score=1 STRING: ENSP00000264156
    MCM7P339931, 3, ENSP000003072884EBI-749378,EBI-355924 I2D: score=1 STRING: ENSP00000307288
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000084mitotic S phase TAS17296731
    GO:0006261DNA-dependent DNA replication IMP--
    GO:0007062sister chromatid cohesion IMP--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with MCMBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MCMBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MCMBP gene (3 alternative transcripts): 
    NM_001256378.1  NM_001256379.1  NM_024834.3  

    Unigene Cluster for MCMBP:

    Minichromosome maintenance complex binding protein
    Hs.124246  [show with all ESTs]
    Unigene Representative Sequence: NM_024834
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360003(uc001leq.1 uc001ler.2 uc001les.1) ENST00000369077
    ENST00000466047 ENST00000495407(uc001let.1) ENST00000569515
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MCMBP (see all 47):
    hsa-miR-29a hsa-miR-570 hsa-miR-3142 hsa-miR-9 hsa-miR-889 hsa-miR-330-3p hsa-miR-3163 hsa-miR-601
    SwitchGear 3'UTR luciferase reporter plasmidMCMBP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MCMBP
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCMBP
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      QuantiTect SYBR Green Assays in human, mouse, rat MCMBP
      QuantiFast Probe-based Assays in human, mouse, rat MCMBP

    Additional mRNA sequence: 

    AK001928.1 AK023143.1 AK094075.1 BC000935.2 BC004183.2 BC007219.1 CR457299.1 

    12 DOTS entries:

    DT.95174649  DT.455894  DT.99994077  DT.100792020  DT.100792019  DT.40107482  DT.101978008  DT.91986611 
    DT.100792024  DT.92439730  DT.97799962  DT.97846578 

    Selected AceView cDNA sequences (see all 301):

    BQ929053 AA349432 AW771502 BE465917 BE618245 AA809488 AA829470 BE221654 
    NM_024834 AK023143 AI743602 BC004183 AI753861 BU517080 AI332895 AI278309 
    BP337967 BU069493 CA449737 BM807043 AI917203 CA311452 BI261167 BM451450 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MCMBP (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
    SP1:        -                       -     -           -     -           -                             -                                   -                     
    SP2:                                -     -                             -                             -                                   -                     
    SP3:                                -     -                             -                             -                                   -                     
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 17b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MCMBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MCMBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTTTTGA
    MCMBP Expression
    About this image

    MCMBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCMBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124246
        Custom PCR Arrays for MCMBP
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    QuantiFast Probe-based Assays in human, mouse, rat MCMBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCMBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCMBP gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcmbp1 , 5 MCM (minichromosome maintenance deficient) binding more1, 5 85.25(n)1
    92.99(a)1
      7 (70.41 cM)5
    2107111  NM_145955.31  NP_666067.11 
     1286964415 
    chicken
    (Gallus gallus)
    Aves MCMBP1 minichromosome maintenance complex binding protein 79.39(n)
    84.07(a)
      423933  NM_001012912.1  NP_001012930.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCMBP6
    minichromosome maintenance complex binding protein...
    80(a)
    1 ↔ 1
    3(66170104-66205716)
    African clawed frog
    (Xenopus laevis)
    Amphibia flj13081-prov2 hypothetical protein MGC52627 75.96(n)    BC042336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.49892 Danio rerio mRNA similar to hypothetical protein FLJ13 more 73.61(n)    BC044562.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG34301 CG3430 46.59(n)
    39.96(a)
      33976  NM_080707.3  NP_542438.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ETG11 ETG1 46(n)
    36.41(a)
      818650  NM_129617.4  NP_181587.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01668001 Os01g0166800 45.05(n)
    34.27(a)
      4327146  NM_001048653.1  NP_001042118.1 


    ENSEMBL Gene Tree for MCMBP (if available)
    TreeFam Gene Tree for MCMBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCMBP (see all 997)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922461871,2
    --121589210(+) TCAGCG/TCTCTC 3 -- ut310--------
    rs1846350111,2
    --121589234(+) AGAGGA/GCATGG 3 -- ut310--------
    rs1501706791,2
    --121589254(+) ACACAA/GATCAC 3 -- ut310--------
    rs1456022961,2
    C--121589264(+) CATGGC/GATGGT 3 -- ut310--------
    rs412879461,2
    C,F--121589274(+) TGAATC/ATTCTT 3 -- ut315Minor allele frequency- A:0.10NA WA CSA 243
    rs1402544641,2
    --121589366(+) AAGACC/TAAGCA 3 -- ut310--------
    rs1892992151,2
    --121589375(+) CAATGC/TATGTA 3 -- ut310--------
    rs68811,2
    C,F,A,H--121589402(-) TGTAAC/ATTGTA 3 -- ut3113Minor allele frequency- A:0.42MN NS EA NA WA 1038
    rs1452339731,2
    C--121589427(+) ACATGA/GTGACT 3 -- ut310--------
    rs140851,2
    C,F--121589576(+) TAAACA/CTTATT 3 -- ut312Minor allele frequency- C:0.01MN WA 186

    HapMap Linkage Disequilibrium report for MCMBP (121588972 - 121652068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MCMBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7571CNV Insertion18451855
    nsv896044CNV Gain21882294
    esv259861OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MCMBP
    DNA2.0 Custom Variant and Variant Library Synthesis for MCMBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610909    OMIM disorders: --


    Find genes that share disorders with MCMBP           About GenesLikeMe


    Export disorders for MCMBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MCMBP gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MCMBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)1, 2, 3 Sakwe A.M.... Frappier L. (Mol. Cell. Biol. 2007)
    2. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. (PubMed id 21196493)1, 2 Nishiyama A.... Mechali M. (Genes Dev. 2011)
    3. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. (PubMed id 20090939)1, 2 Takahashi N.... De Veylder L. (PLoS Genet. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A role for USP7 in DNA replication. (PubMed id 24190967)1 Jagannathan M....Frappier L. (Mol. Cell. Biol. 2014)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. The MCM-associated protein MCM-BP is important for human nuclear morphology. (PubMed id 22250201)1 Jagannathan M....Frappier L. (J. Cell. Sci. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79892 HGNC: 25782 AceView: C10orf119 Ensembl:ENSG00000197771 euGenes: HUgn79892
    ECgene: MCMBP H-InvDB: MCMBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MCMBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MCMBP gene:
    Search GeneIP for patents involving MCMBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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