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Aliases for MCMBP Gene

Aliases for MCMBP Gene

  • Minichromosome Maintenance Complex Binding Protein 2 3
  • MCM-Binding Protein 3 4
  • C10orf119 3 4
  • MCM-BP 3 4
  • Minichromosome Maintenance Complex-Binding Protein 3
  • Chromosome 10 Open Reading Frame 119 2

External Ids for MCMBP Gene

Previous HGNC Symbols for MCMBP Gene

  • C10orf119

Previous GeneCards Identifiers for MCMBP Gene

  • GC10M121588

Summaries for MCMBP Gene

Entrez Gene Summary for MCMBP Gene

  • This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MCMBP Gene

MCMBP (Minichromosome Maintenance Complex Binding Protein) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for MCMBP Gene

  • Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCMBP Gene

Genomics for MCMBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCMBP Gene

Chromosome:
10
Start:
119,829,404 bp from pter
End:
119,892,556 bp from pter
Size:
63,153 bases
Orientation:
Minus strand

Genomic View for MCMBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCMBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCMBP Gene

No data available for Regulatory Elements for MCMBP Gene

Proteins for MCMBP Gene

  • Protein details for MCMBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE3-MCMBP_HUMAN
    Recommended name:
    Mini-chromosome maintenance complex-binding protein
    Protein Accession:
    Q9BTE3
    Secondary Accessions:
    • B3KSP7
    • Q6IA56
    • Q9BVT9
    • Q9H916

    Protein attributes for MCMBP Gene

    Size:
    642 amino acids
    Molecular mass:
    72980 Da
    Quaternary structure:
    • Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone.

    Three dimensional structures from OCA and Proteopedia for MCMBP Gene

    Alternative splice isoforms for MCMBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCMBP Gene

Proteomics data for MCMBP Gene at MOPED

Post-translational modifications for MCMBP Gene

  • Ubiquitination at Lys 47, Lys 61, Lys 67, Lys 142, Lys 314, Lys 388, Lys 431, Lys 582, Lys 621, Lys 635, and Lys 332
  • Modification sites at PhosphoSitePlus

Other Protein References for MCMBP Gene

No data available for DME Specific Peptides for MCMBP Gene

Domains & Families for MCMBP Gene

Protein Domains for MCMBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCMBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTE3

UniProtKB/Swiss-Prot:

MCMBP_HUMAN :
  • Belongs to the MCMBP family.
Family:
  • Belongs to the MCMBP family.
genes like me logo Genes that share domains with MCMBP: view

No data available for Gene Families for MCMBP Gene

Function for MCMBP Gene

Molecular function for MCMBP Gene

UniProtKB/Swiss-Prot Function:
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Gene Ontology (GO) - Molecular Function for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17296731
GO:0005515 protein binding IPI 17296731
genes like me logo Genes that share ontologies with MCMBP: view

Phenotypes for MCMBP Gene

GenomeRNAi human phenotypes for MCMBP:
genes like me logo Genes that share phenotypes with MCMBP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCMBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MCMBP Gene

Localization for MCMBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCMBP Gene

Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCMBP Gene COMPARTMENTS Subcellular localization image for MCMBP gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17296731
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0042555 colocalizes_with MCM complex IDA 17296731
genes like me logo Genes that share ontologies with MCMBP: view

Pathways & Interactions for MCMBP Gene

SuperPathways for MCMBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006261 DNA-dependent DNA replication IMP 21196493
GO:0007062 sister chromatid cohesion IMP 20090939
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MCMBP: view

No data available for Pathways by source and SIGNOR curated interactions for MCMBP Gene

Drugs & Compounds for MCMBP Gene

No Compound Related Data Available

Transcripts for MCMBP Gene

Unigene Clusters for MCMBP Gene

Minichromosome maintenance complex binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCMBP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCMBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:
SP7:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MCMBP Gene

GeneLoc Exon Structure for
MCMBP
ECgene alternative splicing isoforms for
MCMBP

Expression for MCMBP Gene

mRNA expression in normal human tissues for MCMBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCMBP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6) and Lymph node (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCMBP Gene



SOURCE GeneReport for Unigene cluster for MCMBP Gene Hs.124246

genes like me logo Genes that share expression patterns with MCMBP: view

Protein tissue co-expression partners for MCMBP Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCMBP Gene

Orthologs for MCMBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCMBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCMBP 35
  • 90.97 (n)
  • 96.73 (a)
MCMBP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCMBP 35
  • 91.23 (n)
  • 97.04 (a)
-- 36
  • 97 (a)
OneToMany
C10ORF119 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mcmbp 35
  • 85.25 (n)
  • 92.99 (a)
Mcmbp 16
Mcmbp 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCMBP 35
  • 99.64 (n)
  • 100 (a)
MCMBP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306730 35
  • 85.77 (n)
  • 94.08 (a)
oppossum
(Monodelphis domestica)
Mammalia MCMBP 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCMBP 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCMBP 35
  • 79.39 (n)
  • 84.07 (a)
MCMBP 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCMBP 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcmbp 35
  • 67.25 (n)
  • 72.32 (a)
Str.19983 35
African clawed frog
(Xenopus laevis)
Amphibia flj13081-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4989 35
mcmbp 35
  • 64.5 (n)
  • 66.83 (a)
mcmbp 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6706 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011536 35
  • 46.06 (n)
  • 39.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3430 35
  • 46.59 (n)
  • 39.96 (a)
CG3430 36
  • 37 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ETG1 35
  • 46 (n)
  • 36.41 (a)
rice
(Oryza sativa)
Liliopsida Os01g0166800 35
  • 45.05 (n)
  • 34.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for MCMBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCMBP Gene

ENSEMBL:
Gene Tree for MCMBP (if available)
TreeFam:
Gene Tree for MCMBP (if available)

Paralogs for MCMBP Gene

No data available for Paralogs for MCMBP Gene

Variants for MCMBP Gene

Sequence variations from dbSNP and Humsavar for MCMBP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs6881 -- 119,829,890(-) TGTAA(A/C)TTGTA utr-variant-3-prime
rs10550 -- 119,830,262(-) ATCAA(A/G)TAACT utr-variant-3-prime
rs14085 -- 119,830,064(+) TAAAC(A/C)TTATT utr-variant-3-prime
rs2145963 -- 119,848,363(+) tccca(A/G)aactt intron-variant
rs2244165 -- 119,837,648(+) GCGTG(A/G)TGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCMBP Gene

Variant ID Type Subtype PubMed ID
nsv896044 CNV Gain 21882294
nsv7571 CNV Insertion 18451855
esv259861 OTHER Complex 20981092

Variation tolerance for MCMBP Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCMBP Gene

HapMap Linkage Disequilibrium report
MCMBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCMBP Gene

Disorders for MCMBP Gene

Relevant External Links for MCMBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCMBP
genes like me logo Genes that share disorders with MCMBP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCMBP Gene

Publications for MCMBP Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 2 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for MCMBP Gene

Sources for MCMBP Gene

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