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Aliases for MCMBP Gene

Aliases for MCMBP Gene

  • Minichromosome Maintenance Complex Binding Protein 2 3
  • C10orf119 3 4 6
  • MCM-Binding Protein 3 4
  • MCM-BP 3 4
  • Mini-Chromosome Maintenance Complex-Binding Protein 3
  • Minichromosome Maintenance Complex-Binding Protein 3
  • Chromosome 10 Open Reading Frame 119 2

External Ids for MCMBP Gene

Previous HGNC Symbols for MCMBP Gene

  • C10orf119

Previous GeneCards Identifiers for MCMBP Gene

  • GC10M121588

Summaries for MCMBP Gene

Entrez Gene Summary for MCMBP Gene

  • This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MCMBP Gene

MCMBP (Minichromosome Maintenance Complex Binding Protein) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for MCMBP Gene

  • Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCMBP Gene

Genomics for MCMBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCMBP Gene

Start:
119,829,404 bp from pter
End:
119,892,556 bp from pter
Size:
63,153 bases
Orientation:
Minus strand

Genomic View for MCMBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCMBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCMBP Gene

No data available for Regulatory Elements for MCMBP Gene

Proteins for MCMBP Gene

  • Protein details for MCMBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE3-MCMBP_HUMAN
    Recommended name:
    Mini-chromosome maintenance complex-binding protein
    Protein Accession:
    Q9BTE3
    Secondary Accessions:
    • B3KSP7
    • Q6IA56
    • Q9BVT9
    • Q9H916

    Protein attributes for MCMBP Gene

    Size:
    642 amino acids
    Molecular mass:
    72980 Da
    Quaternary structure:
    • Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone.

    Three dimensional structures from OCA and Proteopedia for MCMBP Gene

    Alternative splice isoforms for MCMBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCMBP Gene

Proteomics data for MCMBP Gene at MOPED

Post-translational modifications for MCMBP Gene

  • Ubiquitination at Lys47, Lys61, Lys67, Lys142, Lys314, Lys388, Lys431, Lys582, Lys621, Lys635, and Lys332
  • Modification sites at PhosphoSitePlus

Other Protein References for MCMBP Gene

No data available for DME Specific Peptides for MCMBP Gene

Domains for MCMBP Gene

Protein Domains for MCMBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCMBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTE3

UniProtKB/Swiss-Prot:

MCMBP_HUMAN :
  • Q9BTE3
Family:
  • Belongs to the MCMBP family.
genes like me logo Genes that share domains with MCMBP: view

No data available for Gene Families for MCMBP Gene

Function for MCMBP Gene

Molecular function for MCMBP Gene

UniProtKB/Swiss-Prot Function: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Gene Ontology (GO) - Molecular Function for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17296731
GO:0005515 protein binding IPI 17296731
genes like me logo Genes that share ontologies with MCMBP: view

Phenotypes for MCMBP Gene

GenomeRNAi human phenotypes for MCMBP:
genes like me logo Genes that share phenotypes with MCMBP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCMBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCMBP Gene

Localization for MCMBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCMBP Gene

Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.

Gene Ontology (GO) - Cellular Components for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17296731
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0042555 colocalizes_with MCM complex IDA 17296731
genes like me logo Genes that share ontologies with MCMBP: view

No data available for Subcellular locations from COMPARTMENTS for MCMBP Gene

Pathways for MCMBP Gene

SuperPathways for MCMBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006261 DNA-dependent DNA replication IMP 21196493
GO:0007062 sister chromatid cohesion IMP 20090939
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MCMBP: view

No data available for Pathways by source for MCMBP Gene

Transcripts for MCMBP Gene

Unigene Clusters for MCMBP Gene

Minichromosome maintenance complex binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCMBP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCMBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:
SP7:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MCMBP Gene

GeneLoc Exon Structure for
MCMBP
ECgene alternative splicing isoforms for
MCMBP

Expression for MCMBP Gene

mRNA expression in normal human tissues for MCMBP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCMBP Gene

SOURCE GeneReport for Unigene cluster for MCMBP Gene Hs.124246

genes like me logo Genes that share expressions with MCMBP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCMBP Gene

Orthologs for MCMBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCMBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCMBP 35
  • 99.64 (n)
  • 100 (a)
MCMBP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCMBP 35
  • 90.97 (n)
  • 96.73 (a)
MCMBP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
C10ORF119 36
  • 94 (a)
OneToMany
MCMBP 35
  • 91.23 (n)
  • 97.04 (a)
mouse
(Mus musculus)
Mammalia Mcmbp 35
  • 85.25 (n)
  • 92.99 (a)
Mcmbp 16
Mcmbp 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCMBP 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCMBP 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306730 35
  • 85.77 (n)
  • 94.08 (a)
chicken
(Gallus gallus)
Aves MCMBP 35
  • 79.39 (n)
  • 84.07 (a)
MCMBP 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCMBP 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj13081-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mcmbp 35
  • 67.25 (n)
  • 72.32 (a)
Str.19983 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6706 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4989 35
mcmbp 35
  • 64.5 (n)
  • 66.83 (a)
mcmbp 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011536 35
  • 46.06 (n)
  • 39.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3430 35
  • 46.59 (n)
  • 39.96 (a)
CG3430 36
  • 37 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ETG1 35
  • 46 (n)
  • 36.41 (a)
rice
(Oryza sativa)
Liliopsida Os01g0166800 35
  • 45.05 (n)
  • 34.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for MCMBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCMBP Gene

ENSEMBL:
Gene Tree for MCMBP (if available)
TreeFam:
Gene Tree for MCMBP (if available)

Paralogs for MCMBP Gene

No data available for Paralogs for MCMBP Gene

Variants for MCMBP Gene

Sequence variations from dbSNP and Humsavar for MCMBP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs6881 -- 119,829,890(-) TGTAA(A/C)TTGTA utr-variant-3-prime
rs10550 -- 119,830,262(-) ATCAA(A/G)TAACT utr-variant-3-prime
rs14085 -- 119,830,064(+) TAAAC(A/C)TTATT utr-variant-3-prime
rs2145963 -- 119,848,363(+) tccca(A/G)aactt intron-variant
rs2244165 -- 119,837,648(+) GCGTG(A/G)TGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCMBP Gene

Variant ID Type Subtype PubMed ID
nsv896044 CNV Gain 21882294
nsv7571 CNV Insertion 18451855
esv259861 OTHER Complex 20981092

Relevant External Links for MCMBP Gene

HapMap Linkage Disequilibrium report
MCMBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCMBP Gene

Disorders for MCMBP Gene

No disorders were found for MCMBP Gene.

No data available for UniProtKB/Swiss-Prot for MCMBP Gene

Publications for MCMBP Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. (PMID: 20090939) Takahashi N. … De Veylder L. (PLoS Genet. 2010) 3 4
  5. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. (PMID: 21196493) Nishiyama A. … Mechali M. (Genes Dev. 2011) 3 4

Products for MCMBP Gene

Sources for MCMBP Gene

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