Free for academic non-profit institutions. Other users need a Commercial license

MCMBP Gene(Protein Coding)

Minichromosome Maintenance Complex Binding Protein

GCID:
GC10M119829
GIFtS:
38
Genes Participants
UDN Logo

Aliases for MCMBP Gene

Aliases for MCMBP Gene

  • Minichromosome Maintenance Complex Binding Protein 2 3 5
  • MCM-Binding Protein 3 4
  • C10orf119 3 4
  • MCM-BP 3 4
  • Mini-Chromosome Maintenance Complex-Binding Protein 3
  • Chromosome 10 Open Reading Frame 119 2

External Ids for MCMBP Gene

Previous HGNC Symbols for MCMBP Gene

  • C10orf119

Previous GeneCards Identifiers for MCMBP Gene

  • GC10M121588

Summaries for MCMBP Gene

Entrez Gene Summary for MCMBP Gene

  • This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MCMBP Gene

MCMBP (Minichromosome Maintenance Complex Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for MCMBP Gene

  • Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Additional gene information for MCMBP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCMBP Gene

Genomics for MCMBP Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MCMBP Gene

Promoters and enhancers for MCMBP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10I119891 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557.7 -0.2 -160 2.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 MCMBP SEC23IP INPP5F MIR4682
GH10I119871 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.2 +19.9 19939 3.2 PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 SP3 ZHX2 REST ZNF592 MCMBP SEC23IP TIAL1 WDR11 INPP5F ENSG00000282413
GH10I119078 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.8 +812.4 812355 4 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 EIF3A GC10P119080 TIAL1 SEC23IP MCMBP NANOS1 RN7SL749P ENSG00000222588
GH10I119594 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.9 +296.1 296096 3.3 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 TIAL1 LOC105378512 GC10P119597 SEC23IP MCMBP ENSG00000271353 RGS10
GH10I119650 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +236.9 236925 10.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B FOS BAG3 TIAL1 SEC23IP INPP5F MCMBP GRK5 TXNP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MCMBP on UCSC Golden Path with GeneCards custom track

Genomic Locations for MCMBP Gene

Genomic Locations for MCMBP Gene
chr10:119,829,404-119,892,556
(GRCh38/hg38)
Size:
63,153 bases
Orientation:
Minus strand
chr10:121,588,972-121,652,068
(GRCh37/hg19)

Genomic View for MCMBP Gene

Genes around MCMBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCMBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCMBP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MCMBP Gene

Proteins for MCMBP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MCMBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE3-MCMBP_HUMAN
    Recommended name:
    Mini-chromosome maintenance complex-binding protein
    Protein Accession:
    Q9BTE3
    Secondary Accessions:
    • B3KSP7
    • Q6IA56
    • Q9BVT9
    • Q9H916

    Protein attributes for MCMBP Gene

    Size:
    642 amino acids
    Molecular mass:
    72980 Da
    Quaternary structure:
    • Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone.

    Three dimensional structures from OCA and Proteopedia for MCMBP Gene

    Alternative splice isoforms for MCMBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCMBP Gene

Protein Expression for MCMBP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MCMBP Gene

  • Ubiquitination at posLast=4747, isoforms=261, posLast=6767, posLast=142142, isoforms=2, 3314, isoforms=2, 3388, posLast=431431, posLast=582582, isoforms=2, 3621, isoforms=2, 3635, and posLast=332332

Other Protein References for MCMBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCMBP Gene

Domains & Families for MCMBP Gene

Gene Families for MCMBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MCMBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCMBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTE3

UniProtKB/Swiss-Prot:

MCMBP_HUMAN :
  • Belongs to the MCMBP family.
Family:
  • Belongs to the MCMBP family.
genes like me logo Genes that share domains with MCMBP: view

Function for MCMBP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MCMBP Gene

UniProtKB/Swiss-Prot Function:
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Gene Ontology (GO) - Molecular Function for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17296731
GO:0005515 protein binding IPI 17296731
genes like me logo Genes that share ontologies with MCMBP: view
genes like me logo Genes that share phenotypes with MCMBP: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCMBP Gene

Localization for MCMBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCMBP Gene

Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCMBP gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IDA,IEA 17296731
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MCMBP: view

Pathways & Interactions for MCMBP Gene

SuperPathways for MCMBP Gene

PathCards logo More details on SuperPathways for MCMBP
No Data Available

Gene Ontology (GO) - Biological Process for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006261 DNA-dependent DNA replication IMP 21196493
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion IMP 20090939
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MCMBP: view

No data available for Pathways by source and SIGNOR curated interactions for MCMBP Gene

Drugs & Compounds for MCMBP Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MCMBP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MCMBP Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(301) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MCMBP Gene

Minichromosome maintenance complex binding protein:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCMBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:
SP7:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MCMBP Gene

GeneLoc Exon Structure for
MCMBP
ECgene alternative splicing isoforms for
MCMBP

Expression for MCMBP Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCMBP Gene

mRNA expression in normal human tissues for MCMBP Gene
mRNA expression by BioGPS for MCMBP GenemRNA expression by GTEx for MCMBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCMBP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6) and Lymph node (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCMBP Gene



Protein tissue co-expression partners for MCMBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MCMBP Gene:

MCMBP

SOURCE GeneReport for Unigene cluster for MCMBP Gene:

Hs.124246

Evidence on tissue expression from TISSUES for MCMBP Gene

  • Liver(4.2)
  • Muscle(4.2)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with MCMBP: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCMBP Gene

Orthologs for MCMBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCMBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MCMBP 33 34
  • 99.64 (n)
dog
(Canis familiaris)
 Mammalia -- 34
  • 97 (a)
 OneToMany
C10ORF119 34
  • 94 (a)
 OneToMany
MCMBP 33
  • 91.23 (n)
cow
(Bos Taurus)
 Mammalia MCMBP 33 34
  • 90.97 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MCMBP 34
  • 90 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MCMBP 34
  • 88 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia RGD1306730 33
  • 85.77 (n)
mouse
(Mus musculus)
 Mammalia Mcmbp 33 16 34
  • 85.25 (n)
chicken
(Gallus gallus)
 Aves MCMBP 33 34
  • 79.39 (n)
lizard
(Anolis carolinensis)
 Reptilia MCMBP 34
  • 80 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mcmbp 33
  • 67.25 (n)
Str.19983 33
African clawed frog
(Xenopus laevis)
 Amphibia flj13081-prov 33
zebrafish
(Danio rerio)
 Actinopterygii mcmbp 33 34
  • 64.5 (n)
Dr.4989 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6706 33
fruit fly
(Drosophila melanogaster)
 Insecta CG3430 33 34
  • 46.59 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP011536 33
  • 46.06 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons ETG1 33
  • 46 (n)
rice
(Oryza sativa)
 Liliopsida Os01g0166800 33
  • 45.05 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 38 (a)
 OneToOne
Species where no ortholog for MCMBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCMBP Gene

ENSEMBL:
Gene Tree for MCMBP (if available)
TreeFam:
Gene Tree for MCMBP (if available)

Paralogs for MCMBP Gene

No data available for Paralogs for MCMBP Gene

Variants for MCMBP Gene

Sequence variations from dbSNP and Humsavar for MCMBP Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000007053 -- 119,866,734(-) T/A intron_variant
rs1000099148 -- 119,866,347(-) C/T intron_variant
rs1000161336 -- 119,872,208(-) C/G intron_variant
rs1000227831 -- 119,866,433(-) C/G intron_variant
rs1000238337 -- 119,840,581(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MCMBP Gene

Variant ID Type Subtype PubMed ID
esv2858458 CNV duplication 24192839
esv3302887 CNV tandem duplication 20981092
esv3344248 CNV insertion 20981092
esv3421920 CNV insertion 20981092
nsv1045668 CNV gain 25217958
nsv1121822 CNV deletion 24896259
nsv7571 CNV insertion 18451855

Variation tolerance for MCMBP Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCMBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCMBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCMBP Gene

Disorders for MCMBP Gene

Additional Disease Information for MCMBP

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MCMBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCMBP Gene

Publications for MCMBP Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe AM … Frappier L (Molecular and cellular biology 2007) 2 3 4 58
  2. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. (PMID: 21196493) Nishiyama A … Méchali M (Genes & development 2011) 3 4 58
  3. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. (PMID: 20090939) Takahashi N … De Veylder L (PLoS genetics 2010) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MCMBP Gene

Sources for MCMBP Gene

Content
Loading form....