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Aliases for MCMBP Gene

Aliases for MCMBP Gene

  • Minichromosome Maintenance Complex Binding Protein 2 3 5
  • MCM-Binding Protein 3 4
  • C10orf119 3 4
  • MCM-BP 3 4
  • Mini-Chromosome Maintenance Complex-Binding Protein 3
  • Chromosome 10 Open Reading Frame 119 2

External Ids for MCMBP Gene

Previous HGNC Symbols for MCMBP Gene

  • C10orf119

Previous GeneCards Identifiers for MCMBP Gene

  • GC10M121588

Summaries for MCMBP Gene

Entrez Gene Summary for MCMBP Gene

  • This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MCMBP Gene

MCMBP (Minichromosome Maintenance Complex Binding Protein) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for MCMBP Gene

  • Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCMBP Gene

Genomics for MCMBP Gene

Regulatory Elements for MCMBP Gene

Enhancers for MCMBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G119677 1.4 Ensembl ENCODE dbSUPER 21.6 +212.0 211986 5.3 TBP KLF17 RAD21 ZBTB7B GTF3C2 ZNF121 GLIS2 EGR1 SMARCC2 ZNF548 SEC23IP MCMBP RPL17P36 INPP5F PHACTR2P1 TXNP1 BAG3
GH10G119089 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +801.6 801614 3.0 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 SSRP1 ZNF610 SEC23IP MCMBP INPP5F ENSG00000222588 SNORA19 NANOS1 RPL17P36 ENSG00000271343 GC10P119080
GH10G119650 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +236.9 236925 10.1 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 SEC23IP BAG3 INPP5F TIAL1 MCMBP PHACTR2P1 GRK5 TXNP1
GH10G119333 1.3 Ensembl ENCODE dbSUPER 13 +556.4 556401 5.5 PKNOX1 TFAP4 ATF1 ZBTB21 KLF17 FEZF1 ZIC2 ZBTB40 FOXM1 POLR2A SEC23IP RPL17P36 MCMBP LOC105378511 GC10P119246
GH10G119783 1.6 FANTOM5 Ensembl ENCODE 10.4 +107.1 107074 4.2 FOXA2 ATF1 ARID4B FEZF1 DMAP1 YY1 GTF3C2 ZNF121 ZNF202 SP5 INPP5F SEC23IP RPL17P36 MCMBP TXNP1 RN7SL846P GC10M119816
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCMBP on UCSC Golden Path with GeneCards custom track

Promoters for MCMBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034352 -244 2001 HDGF PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for MCMBP Gene

Chromosome:
10
Start:
119,829,404 bp from pter
End:
119,892,556 bp from pter
Size:
63,153 bases
Orientation:
Minus strand

Genomic View for MCMBP Gene

Genes around MCMBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCMBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCMBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCMBP Gene

Proteins for MCMBP Gene

  • Protein details for MCMBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE3-MCMBP_HUMAN
    Recommended name:
    Mini-chromosome maintenance complex-binding protein
    Protein Accession:
    Q9BTE3
    Secondary Accessions:
    • B3KSP7
    • Q6IA56
    • Q9BVT9
    • Q9H916

    Protein attributes for MCMBP Gene

    Size:
    642 amino acids
    Molecular mass:
    72980 Da
    Quaternary structure:
    • Interacts with the MCM complex: associates with the MCM3-7 complex which lacks MCM2, while it does not interact with the MCM complex when MCM2 is present (MCM2-7 complex). Interacts with the RPA complex, when composed of all RPA1, RPA2 and RPA3 components, but not with RPA1 or RPA2 alone.

    Three dimensional structures from OCA and Proteopedia for MCMBP Gene

    Alternative splice isoforms for MCMBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCMBP Gene

Post-translational modifications for MCMBP Gene

  • Ubiquitination at Lys47, posLast=6161, posLast=6767, posLast=142142, Lys314, Lys388, posLast=431431, Lys582, posLast=621621, posLast=635635, and Lys332
  • Modification sites at PhosphoSitePlus

Other Protein References for MCMBP Gene

No data available for DME Specific Peptides for MCMBP Gene

Domains & Families for MCMBP Gene

Protein Domains for MCMBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCMBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTE3

UniProtKB/Swiss-Prot:

MCMBP_HUMAN :
  • Belongs to the MCMBP family.
Family:
  • Belongs to the MCMBP family.
genes like me logo Genes that share domains with MCMBP: view

No data available for Gene Families for MCMBP Gene

Function for MCMBP Gene

Molecular function for MCMBP Gene

UniProtKB/Swiss-Prot Function:
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Gene Ontology (GO) - Molecular Function for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17296731
GO:0005515 protein binding IPI 17296731
genes like me logo Genes that share ontologies with MCMBP: view
genes like me logo Genes that share phenotypes with MCMBP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCMBP Gene

Localization for MCMBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCMBP Gene

Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCMBP gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IDA,IEA 17296731
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MCMBP: view

Pathways & Interactions for MCMBP Gene

SuperPathways for MCMBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCMBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006261 DNA-dependent DNA replication IMP 21196493
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion IMP 20090939
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with MCMBP: view

No data available for Pathways by source and SIGNOR curated interactions for MCMBP Gene

Drugs & Compounds for MCMBP Gene

No Compound Related Data Available

Transcripts for MCMBP Gene

Unigene Clusters for MCMBP Gene

Minichromosome maintenance complex binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCMBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6:
SP7:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MCMBP Gene

GeneLoc Exon Structure for
MCMBP
ECgene alternative splicing isoforms for
MCMBP

Expression for MCMBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCMBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCMBP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6) and Lymph node (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCMBP Gene



Protein tissue co-expression partners for MCMBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MCMBP Gene:

MCMBP

SOURCE GeneReport for Unigene cluster for MCMBP Gene:

Hs.124246

Evidence on tissue expression from TISSUES for MCMBP Gene

  • Liver(4.2)
  • Muscle(4.2)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with MCMBP: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCMBP Gene

Orthologs for MCMBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCMBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCMBP 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
C10ORF119 35
  • 94 (a)
OneToMany
MCMBP 34
  • 91.23 (n)
cow
(Bos Taurus)
Mammalia MCMBP 34 35
  • 90.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MCMBP 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCMBP 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306730 34
  • 85.77 (n)
mouse
(Mus musculus)
Mammalia Mcmbp 34 16 35
  • 85.25 (n)
chicken
(Gallus gallus)
Aves MCMBP 34 35
  • 79.39 (n)
lizard
(Anolis carolinensis)
Reptilia MCMBP 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcmbp 34
  • 67.25 (n)
Str.19983 34
African clawed frog
(Xenopus laevis)
Amphibia flj13081-prov 34
zebrafish
(Danio rerio)
Actinopterygii mcmbp 34 35
  • 64.5 (n)
Dr.4989 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6706 34
fruit fly
(Drosophila melanogaster)
Insecta CG3430 34 35
  • 46.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011536 34
  • 46.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ETG1 34
  • 46 (n)
rice
(Oryza sativa)
Liliopsida Os01g0166800 34
  • 45.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for MCMBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCMBP Gene

ENSEMBL:
Gene Tree for MCMBP (if available)
TreeFam:
Gene Tree for MCMBP (if available)

Paralogs for MCMBP Gene

No data available for Paralogs for MCMBP Gene

Variants for MCMBP Gene

Sequence variations from dbSNP and Humsavar for MCMBP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000007053 -- 119,866,734(+) GTGAA(A/T)TTTAT intron-variant
rs1000099148 -- 119,866,347(+) GTGGC(C/T)GGGCG intron-variant
rs1000161336 -- 119,872,208(+) GGGGC(C/G)CTGGC intron-variant
rs1000227831 -- 119,866,433(+) GCAGC(C/G)TGACC intron-variant
rs1000238337 -- 119,840,581(+) AATTG(C/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCMBP Gene

Variant ID Type Subtype PubMed ID
esv2858458 CNV duplication 24192839
esv3302887 CNV tandem duplication 20981092
esv3344248 CNV insertion 20981092
esv3421920 CNV insertion 20981092
nsv1045668 CNV gain 25217958
nsv1121822 CNV deletion 24896259
nsv7571 CNV insertion 18451855

Variation tolerance for MCMBP Gene

Residual Variation Intolerance Score: 5.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCMBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCMBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCMBP Gene

Disorders for MCMBP Gene

Relevant External Links for MCMBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCMBP

No disorders were found for MCMBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCMBP Gene

Publications for MCMBP Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 2 3 4 64
  2. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. (PMID: 21196493) Nishiyama A. … Mechali M. (Genes Dev. 2011) 3 4 64
  3. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. (PMID: 20090939) Takahashi N. … De Veylder L. (PLoS Genet. 2010) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MCMBP Gene

Sources for MCMBP Gene

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