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MCM9 Gene

protein-coding   GIFtS: 48
GCID: GC06M119136

Minichromosome Maintenance Complex Component 9

(Previous names: minichromosome maintenance deficient domain containing 1,...)
(Previous symbols: MCMDC1, C6orf61)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Minichromosome Maintenance Complex Component 91 2     dJ329L24.32
MCMDC11 2 3 5     DNA Helicase MCM92
C6orf611 2 3     DNA Replication Licensing Factor MCM92
Minichromosome Maintenance Deficient Domain Containing 11 2     EC 3.6.4.123
Mini-Chromosome Maintenance Deficient Domain-Containing Protein 12 3     hMCM93
Chromosome 6 Open Reading Frame 611     Minichromosome Maintenance 93
dJ329L24.12     

External Ids:    HGNC: 214841   Entrez Gene: 2543942   Ensembl: ENSG000001118777   OMIM: 6100985   UniProtKB: Q9NXL93   

Export aliases for MCM9 gene to outside databases

Previous GC identifers: GC06M119255 GC06M116813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MCM9 Gene:
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are
essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been
shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also
binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. (provided by
RefSeq, Nov 2010)

GeneCards Summary for MCM9 Gene:
MCM9 (minichromosome maintenance complex component 9) is a protein-coding gene. Diseases associated with MCM9 include large cell medulloblastoma, and childhood medulloblastoma. GO annotations related to this gene include helicase activity. An important paralog of this gene is MCM2.

UniProtKB/Swiss-Prot: MCM9_HUMAN, Q9NXL9
Function: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA
interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a
hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant
forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork
stabilization and fork restart




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MCM9 gene promoter:
         E2F-3a   E2F-4   E2F-5   Sox5   AML1a   E2F-2   E2F-1   E2F   COMP1   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCM9 promoter sequence
   Search Chromatin IP Primers for MCM9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCM9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.31

MCM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M119136:  view genomic region     (about GC identifiers)

Start:
119,134,605 bp from pter      End:
119,256,327 bp from pter
Size:
121,723 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCM9_HUMAN, Q9NXL9 (See protein sequence)
Recommended Name: DNA helicase MCM9  
Size: 1143 amino acids; 127313 Da
Subunit: Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9
Developmental stage: The expression of isoform L and isoform M is cell cycle regulated: induced in S-phase,
decreases through G2/M, and becomes constant through G1
Sequence caution: Sequence=BAA90991.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG61142.1; Type=Erroneous termination; Positions=1070; Note=Translated as Lys; Sequence=CAX30832.1;
Type=Erroneous gene model prediction;
Secondary accessions: B4DR30 B9DI77 Q2KHJ0 Q8N5S5 Q9HCV5
Alternative splicing: 4 isoforms:  Q9NXL9-1   Q9NXL9-2   Q9NXL9-3   Q9NXL9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCM9: NX_Q9NXL9

Explore proteomics data for MCM9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MCM9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060166.2  NP_694987.1  

    ENSEMBL proteins: 
     ENSP00000314505   ENSP00000406576   ENSP00000312870   ENSP00000394776   ENSP00000426890  

    MCM9 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MCM9
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    Novus Biologicals MCM9 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MCM9

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    Search for Antibodies for MCM9 at Abcam
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    LSBio Antibodies in human, mouse, rat for MCM9

    MCM9 Assay Products:

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    Cloud-Clone Corp. ELISAs for MCM9
    Cloud-Clone Corp. CLIAs for MCM9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012340 NA-bd_OB-fold
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR001208 MCM_DNA-dep_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9NXL9

    ProtoNet protein and cluster: Q9NXL9

    UniProtKB/Swiss-Prot: MCM9_HUMAN, Q9NXL9
    Similarity: Belongs to the MCM family
    Similarity: Contains 1 MCM domain


    MCM9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCM9_HUMAN, Q9NXL9
    Function: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA
    interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a
    hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant
    forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork
    stabilization and fork restart
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    MCM9 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mcm9):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  mortality/aging  reproductive system  tumorigenesis 

    MCM9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mcm9tm1.1Geno for MCM9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MCM9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MCM9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCM9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCM9

    miRNA
    Products:
        
    miRTarBase miRNAs that target MCM9:
    hsa-mir-192-5p (MIRT026373), hsa-mir-215-5p (MIRT024400)

    Block miRNA regulation of human, mouse, rat MCM9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCM9 (see all 9):
    hsa-miR-3132 hsa-miR-4312 hsa-miR-496 hsa-miR-3139 hsa-miR-708 hsa-miR-587 hsa-miR-182 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidMCM9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MCM9
    Predesigned siRNA for gene silencing in human, mouse, rat MCM9

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MCM9

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    OriGene ORF clones in mouse, rat for MCM9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MCM9 (NM_017696)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM9

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MCM9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCM9_HUMAN, Q9NXL9: Nucleus (By similarity). Note=Localizes to nuclear foci and colocalizes with RAD51 (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0097362MCM8-MCM9 complex IDA--

    MCM9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MCM9 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59


    1 BioSystems Pathway for MCM9
        Cell cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MCM9
    Interactions:

        GeneGlobe Interaction Network for MCM9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MCM9 (ENSP000003128704) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GINS1ENSP000002624604STRING: ENSP00000262460
    GINS2ENSP000002534624STRING: ENSP00000253462
    GINS4ENSP000002765334STRING: ENSP00000276533
    HAT1ENSP000002641084STRING: ENSP00000264108
    TEX10ENSP000003640374STRING: ENSP00000364037
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IDA--
    GO:0006260DNA replication IEA--
    GO:0006974cellular response to DNA damage stimulus IDA--
    GO:0007276gamete generation ----
    GO:0007292female gamete generation ISS--

    MCM9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MCM9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MCM9 gene (2 alternative transcripts): 
    NM_017696.2  NM_153255.4  

    Unigene Cluster for MCM9:

    Minichromosome maintenance complex component 9
    Hs.279008  [show with all ESTs]
    Unigene Representative Sequence: NM_017696
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316316(uc021zeh.1) ENST00000458674 ENST00000505485 ENST00000368478
    ENST00000436788 ENST00000316068(uc003pyh.3) ENST00000425154 ENST00000505446

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MCM9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCM9 (see all 9):
    hsa-miR-3132 hsa-miR-4312 hsa-miR-496 hsa-miR-3139 hsa-miR-708 hsa-miR-587 hsa-miR-182 hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidMCM9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MCM9
    Predesigned siRNA for gene silencing in human, mouse, rat MCM9
    Clone
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    OriGene clones in human, mouse for MCM9 (see all 9)
    OriGene ORF clones in mouse, rat for MCM9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MCM9 (NM_017696)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM9
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MCM9
    OriGene qSTAR qPCR primer pairs in human, mouse for MCM9
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MCM9
      QuantiTect SYBR Green Assays in human, mouse, rat MCM9
      QuantiFast Probe-based Assays in human, mouse, rat MCM9

    Additional mRNA sequence: 

    AK000177.1 AK122665.1 AK225233.1 BC024976.1 BC031658.1 

    5 DOTS entries:

    DT.109974  DT.65284447  DT.86848895  DT.91818872  DT.91675488 

    22 AceView cDNA sequences:

    NM_153255 BC024976 BX108374 AK122665 AI684583 BE889335 BI820507 BX649114 
    BM787103 BG723946 BP380066 BU561689 BM750346 BM765594 BC031658 BE709822 
    BI762143 AW152104 BE787366 H82510 H82511 AV741648 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MCM9    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
    SP1:              -                                               -                                             
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                      -                     
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for MCM9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MCM9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCACATT
    MCM9 Expression
    About this image

    MCM9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCM9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279008
        Custom PCR Arrays for MCM9
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MCM9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCM9 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcm91 , 5 minichromosome maintenance complex component 91, 5 79.64(n)1
    75.78(a)1
      10 (27.21 cM)5
    715671  NM_027830.21  NP_082106.21 
     535373245 
    chicken
    (Gallus gallus)
    Aves MCM91 minichromosome maintenance complex component 9 64.33(n)
    61.97(a)
      100857742  XM_003641032.2  XP_003641080.2 
    lizard
    (Anolis carolinensis)
    Reptilia MCM96
    minichromosome maintenance complex component 9
    54(a)
    1 ↔ 1
    1(184821277-184860603)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mcm91 minichromosome maintenance complex component 9 61.32(n)
    59.74(a)
      100490403  XM_004914569.1  XP_004914626.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG799650.12   -- 76.5(n)    BG799650.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCM26
    Protein involved in DNA replication; component of ...
    21(a)
    1 → many
    II(174920-177526) YBL023C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MCM91 MCM9 53.88(n)
    51.44(a)
      815890  NM_126977.3  NP_179021.3 
    rice
    (Oryza sativa)
    Liliopsida Os06g02185001 Os06g0218500 54.84(n)
    52.03(a)
      4340503  NM_001063693.1  NP_001057158.1 


    ENSEMBL Gene Tree for MCM9 (if available)
    TreeFam Gene Tree for MCM9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MCM9 gene
    MCM22  
    3 SIMAP similar genes for MCM9 using alignment to 4 protein entries:     MCM9_HUMAN (see all proteins):
    MCM2    FLJ00323    MCM7

    MCM9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCM9 (see all 2052)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454448721,2
    --119134246(+) TAAGAA/CATGGA 1 -- ds50010--------
    rs1895410241,2
    --119134290(+) ACACTA/GTGGCT 1 -- ds50010--------
    rs1480236731,2
    --119134332(+) GACCAC/TGCCCA 1 -- ds50010--------
    rs1806799021,2
    --119134340(+) CCAGAG/TCAAGA 1 -- ds50010--------
    rs1865913451,2
    --119134354(+) AGCTGA/GTCAAA 1 -- ds50010--------
    rs69299561,2
    C,F,H--119134432(+) GAAAGA/TTTAGG 1 -- ds50015Minor allele frequency- T:0.03NS EA WA 534
    rs1173818751,2
    C,F--119134465(+) ACTGGT/CAAATT 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1887351011,2
    --119134506(+) TAATCA/GTTGTT 1 -- ds50010--------
    rs26385401,2
    C,F,H--119134516(-) GACATG/ATATAA 1 -- ds50017Minor allele frequency- A:0.05NS EA WA CSA 534
    rs1418949491,2
    --119134569(+) ACTCAC/TTATGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MCM9 (119134605 - 119256327 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MCM9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677245CNV Deletion23128226
    esv2675335CNV Deletion23128226
    esv2658866CNV Deletion23128226
    esv2660667CNV Deletion23128226
    nsv5453CNV Insertion18451855
    nsv509151CNV Insertion20534489
    nsv437523CNV Loss16327808
    esv29127CNV Gain19812545
    nsv830788CNV Gain17160897
    nsv510910CNV Complex20534489

    Human Gene Mutation Database (HGMD): MCM9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MCM9
    DNA2.0 Custom Variant and Variant Library Synthesis for MCM9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610098    OMIM disorders: --

    5 diseases for MCM9:    
    About MalaCards
    large cell medulloblastoma    childhood medulloblastoma    medulloblastoma    fanconi's anemia
    malaria


    MCM9 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: MCM9 (1 document)

    Export disorders for MCM9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MCM9 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with MCM9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. (PubMed id 16226853)1, 2, 3, 9 Lutzmann M.... Mechali M. (Gene 2005)
    2. Identification of a novel cell-cycle-induced MCM family protein MCM9. (PubMed id 15850810)1, 3, 9 Yoshida K. (Biochem. Biophys. Res. Commun. 2005)
    3. Identification, quantification, and evolutionary analysis of a novel isoform of MCM9. (PubMed id 23403237)1, 2 Jeffries E.P.... Trakselis M.A. (Gene 2013)
    4. MCM proteins and DNA replication. (PubMed id 16495042)1, 3 Maiorano D....MAcchali M. (Curr. Opin. Cell Biol. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. (PubMed id 23401855)1 Park J....Dutta A. (Mol. Cell. Biol. 2013)
    8. Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. (PubMed id 22771115)2 Nishimura K.... Kanemaki M.T. (Mol. Cell 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 254394 HGNC: 21484 AceView: MCMDC1 Ensembl:ENSG00000111877 euGenes: HUgn254394
    ECgene: MCM9 H-InvDB: MCM9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MCM9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MCM9 gene:
    Search GeneIP for patents involving MCM9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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